LOCUS       NZ_CP012382            22181 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6259613
            Orig. end                         :: 6281794
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22181
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="18"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22181
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22181
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12181](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12181
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(194..205)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     gene            194..904
                     /locus_tag="SAM23877_RS27455"
                     /old_locus_tag="SAM23877_5778"
     CDS             194..904
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972858.1"
                     /locus_tag="SAM23877_RS27455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5778"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_053138893.1"
                     /transl_table=11
                     /translation="MNGFFDIPSDLDNTYFGLIGLHLREALLPVLAGLLLALPVAQLCV
                     RFRWLYPPVLGVTTVFYAIPSLAVFVVLIDYTGQTELTVMIPLAVYSLVVLVPAIVDGV
                     RSVPEETLAASTAMGFGPVRRYLQVQLPIAVPAILAGLRVAVSASISLVSVGALIGNQG
                     ALGNLLADAQKYGRPELAVNSVLTTAVLAILCDAALVLVRNLLTPWMPRGGTRRPKAAA
                     VRQGRPETEKAAAR"
     gene            901..1566
                     /locus_tag="SAM23877_RS27460"
                     /old_locus_tag="SAM23877_5779"
     CDS             901..1566
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445352.1"
                     /locus_tag="SAM23877_RS27460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5779"
                     /product="ABC transporter permease"
                     /protein_id="WP_053138896.1"
                     /transl_table=11
                     /translation="MNVINFVNAFFSDSAHWHGYDGIPQRLLEHVQYSLLALGLAAAIG
                     LPAGLLTGHTGRGGNAVAFVATAARALPSFGLLVLIAVAVGIGLLPVMIPLVVLAVPPI
                     LVTTYEAVRSVDPSPVDAARGMGMHESSILFRVELPVALPLILSGLRSAAIQVVSTATI
                     AAYVSLGGIGRYIIDGLYQRDYEKVVGGATLVALLALVTLALFWAAGRLAVSPGVRRR"
     misc_feature    complement(1591..1606)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.3"
                     /tool="antismash"
     misc_feature    complement(1593..1608)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    1594..1608
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.23"
                     /tool="antismash"
     gene            1653..2612
                     /locus_tag="SAM23877_RS27465"
                     /old_locus_tag="SAM23877_5780"
     CDS             1653..2612
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972856.1"
                     /locus_tag="SAM23877_RS27465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5780"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_053138899.1"
                     /transl_table=11
                     /translation="MTSTAHSSRSRTRHTGAAAVALTAAAALLAGCSSSDDTSDNPLAG
                     EKAEAGTVVVGSNNFAESTLLADIYGEALKAKGLKVTYKHNIGSRETTYGLMKNGSVTV
                     LPEYNGSLLAYLDSKAEQKSAEAVNEAAKAGLDEKLTLLESSPAENKDSVSVNAETAKK
                     YGLTAESTLADLKEVAPDLVIGGSPEFQTRQQGLKGLESVYGLKFKSFKALDAGGPLTQ
                     SALTKNTVQAADVFTTDPTIIKEKFVVLKDPENLFGYANVTPLVYKEGLSEEGVAALNA
                     VSAKLDTKTLLDLDAQVQLDKKDPLDVAKEWLASAGLV"
     gene            complement(2633..3247)
                     /locus_tag="SAM23877_RS27470"
                     /old_locus_tag="SAM23877_5781"
     CDS             complement(2633..3247)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326003.1"
                     /locus_tag="SAM23877_RS27470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5781"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_053138902.1"
                     /transl_table=11
                     /translation="MAGSDRTAPAPTAPAPRAAAPDAVKILIAGGFGVGKTTMVGSVSE
                     IAPLRTEEPLTAAGLDVDDLAGIEEKRATTVALDFGRISIGRELVLYLFGTPGQQRFWF
                     MWNDLAIGALGAVVLVDVRRPESSFAAIDFFERRGIPFVVGVNGFHGRHPYPAEAIREA
                     LALPAHVQVLLCDARDRASCRDVLVALIDQLIDAAAGAAAP"
     gene            complement(3234..3593)
                     /locus_tag="SAM23877_RS27475"
                     /old_locus_tag="SAM23877_5782"
     CDS             complement(3234..3593)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445342.1"
                     /locus_tag="SAM23877_RS27475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5782"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_053138905.1"
                     /transl_table=11
                     /translation="MTGGDAGGRLVRPFTLTGGRTRPSRADFTLITTVTAVDPQPSRAA
                     RPQPEHLRILRLCAEPVAVAEIAARLDLPVSVVVILLCDLLEAGRITARPPHLVSRANP
                     DLDLLQKVRDGLGRL"
     gene            complement(3595..4014)
                     /locus_tag="SAM23877_RS27480"
                     /old_locus_tag="SAM23877_5783"
     CDS             complement(3595..4014)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326005.1"
                     /locus_tag="SAM23877_RS27480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5783"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_053138908.1"
                     /transl_table=11
                     /translation="MTRPSPATHTELDQLLTGLVERVADVSQAVVLSEDGLVVSKSTGF
                     LRDDAERLAATASGLMSLSKGVSMDFRGGPVRQALIEMANSYLILTSAGPGAHLVVLTG
                     PNADVGVVAYQMNMLVKKIGEHLSAAPRATAGPGE"
     gene            complement(4011..6437)
                     /locus_tag="SAM23877_RS27485"
                     /old_locus_tag="SAM23877_5784"
     CDS             complement(4011..6437)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326006.1"
                     /locus_tag="SAM23877_RS27485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5784"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_053138911.1"
                     /transl_table=11
                     /translation="MSARTGARRRLGSIRLSLILLALVPGVTLATVWGVTTIQMFSEGL
                     RLRAQTELSRSTGAMGTEAALALQKERSLSAAWLAGPGGDRTDLDAQRRRTDAAVAQLV
                     GRSDAIERAPDRVSERLYSVLGSVGSLEYYRDQVDEPSDITADQALDQYTSIIDEQIHA
                     FQELSQVDDGDLTSQAGPLVALEHAAELVSQEDARLTLAWPSDRMGEEEWAEFAQLVHT
                     RRWLVQDQILPSLRGEAKAQTERILASPEWAALQSVEDQVLAARAAGGEGRIDLPDVRQ
                     RWTTALDEVSDQYAALIRQQTDGLLDRSADEARGLLITAASLSAGGLVALLLCVGMSWR
                     ITRSLSRRLRGLRLATLSLAEERLPEVVARLERGEKVDVESATPPLDYGRDELGQVAQA
                     FNAAQRTAVHTAVELADTRRGFQKVILGIARQSQNLVNMQLGKLDALEREHTDPEILKG
                     LYELDSTASQLRRYEENLVIISGEQPRRTWREPVALVDILRSAVGEVAEYQRVELHTDE
                     EVALAPPAVADVIHLLAELIDNATAYSPAPQPVGVRAAMVAKGLAVEIEDRGLGLSEED
                     YASFNAQLAVAPQFDVVALADDLRLGMFVVARLAHRHGITVTLRSSPYGGTTAIVLIPH
                     DIVVPEPVEGGAGADGAPPAPEAPEAPDAPEALVRVSAAAGEGRPLPVKRPSPAARPAP
                     APAATATEADGLAPLPRRVPQTSLAAELRDEGPVTGQDGPDAAAEDHAAFTAERAAASL
                     AGFQRGTLRAQAAGTDGDTAVDAEPADTPAAEQALSCAAPPTPTADRRPPTKDKP"
     gene            complement(6506..7519)
                     /locus_tag="SAM23877_RS27490"
                     /old_locus_tag="SAM23877_5785"
     CDS             complement(6506..7519)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972851.1"
                     /locus_tag="SAM23877_RS27490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5785"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_053138914.1"
                     /transl_table=11
                     /translation="MSTSPPPTPTPGRLRAAALAAAVCLLAAGCSALGADEDGSAADAA
                     AGAGGDRMKIVMVTHGGEGDAFWDRVRKGAEAAAAKDGVDLTYAGDADTADQADLVRDA
                     IREKADGIAVTLAKPQAMKGPVAEAEAAGIPVVGLNSGIDAWRPTGLLQYFGQDESVAG
                     RAVGDKLNDLRARHALCVIHERGNVALEARCAGVKKTFGGETEMLYVEGTDMKAVGAAV
                     TARLRQDSSIDEVVMNGAAFALTAVEAVAKAGSRAQVATFDLDEDLVAAVKRGDVQFAV
                     DQQPYLQGYLAVDALWLYRTNGNVSGGGVAPVLTGPAFVTRTNADAVARFAAGGTR"
     gene            7897..8544
                     /locus_tag="SAM23877_RS27495"
                     /old_locus_tag="SAM23877_5786"
     CDS             7897..8544
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030630.1"
                     /locus_tag="SAM23877_RS27495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5786"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_053138918.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATILGAAAELFDRQGYESTSLSEIVAHAGVTKGA
                     LYFHFAAKEDLAHAIMELQSLTSRRLAAELDGRGYTSLEALMRLTFDMARLCEEGPVLR
                     AGLRLATGGVAVRPPLPHPFTEWREIASSRLLDAVRQSDVHPDIDVDSVAHTLVCSIVG
                     TRVVGGTLEPDARQPRRLAGMWRLLIRGMVPVTRRARYLTLAARLERELSTA"
     gene            8667..9872
                     /locus_tag="SAM23877_RS27500"
                     /old_locus_tag="SAM23877_5787"
     CDS             8667..9872
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523405.1"
                     /locus_tag="SAM23877_RS27500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5787"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_053138921.1"
                     /transl_table=11
                     /translation="MPDTPPEPAPVILGDEPGSFPHSVLAERHPAILRQVGEAFPYDPE
                     RRAGLDALLASCADGAIEPLPDAADPADRRRWAEWGTDRYAGRSWFDVPWLWAESHFYR
                     RLLDAVGYFGPGPWQGVDPFRPAKLAELGSPETDEELAALDDLAGLPAEERTRALLHGS
                     LWGNRADLGFRLSGNGARTEDRVRALVADDSDVLWSLLPPSAPGTPVPATLCLVADNAG
                     RELVPDLLLVAHLLAEGRIGRAVLHVKPHPYYVSDATPADVLDALRRLVAAGGAAASYG
                     EGLWTALTDGRVTVRVHPFSCAPLPYADMPGDLRAEFASATVTVLKGDLNYRRLVGDRY
                     WPPTTPFADVTGYFPGPVAALRTLKSDVITGLTARTEAALEASGERRWRTSGTHALIQV
                     RG"
     gene            10001..12181
                     /gene="cyc2"
                     /locus_tag="SAM23877_RS27505"
                     /old_locus_tag="SAM23877_5788"
     CDS             10001..12181
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996932.1"
                     /locus_tag="SAM23877_RS27505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5788"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_053138925.1"
                     /sec_met_domain="T1TS (E-value: 5.5e-78, bitscore: 262.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQQPFELPHFYLPHPARLNPHLDEARAHSTTWAREMGMLEGSGV
                     WEQSDLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLEKFKRTQDRVGGKT
                     HLDRLSLFMPLDLAAGMPEPENPVEAGLADLWTRTVPAMSAEWRRRFAVATEHLLNESL
                     WELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPTAVAGSRPLRVLMETFS
                     DAVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQEAAELVNDVLTSRLHQFEHTA
                     FTEVPAVALENGLSPAEVAAVGAYAKGLQDWQSGGHEWHMRSSRYMNKGARPAAGWQAL
                     TGPGTSAADVGALLTAAAAGRRRPYTYVPFQKVGPSVIPDIRMPFPLELSPALEGARRH
                     LSEWCRAMGILSEGVWDQDKLASCDLPLCAAGLDPDATQEQLDLASGWLAFGTYGDDYY
                     PLVYGHRRDLAAARLTTARLSACMPLDGEPVPPPANAMERSLIDLWTRTTAGMTPGQRR
                     PLKTAVDKMTEAWVWELANQIQNRVPDPVDYLEMRRATFGSDLTLGLCRAGHGPAVPPE
                     VYRSGPVRSLENAAIDYACLLNDVFSYQKEIEYEGEIHNAILVVQNFFGVDYPAALTVV
                     QDLMNQRMRQFEHVVAHELPVVYDDFRLSDEARGVMAGYVTDLQNWMAGILNWHREVPR
                     YKADYLARRTHGFLPDRIPAVPVPRLSTVPTA"
     gene            12257..12859
                     /locus_tag="SAM23877_RS27510"
                     /old_locus_tag="SAM23877_5789"
     CDS             12257..12859
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327594.1"
                     /locus_tag="SAM23877_RS27510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5789"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_053138928.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGREPRAGAAPADVRRPHTGRRRRRRLTTVLLGV
                     CAATALLLAGVGLGTVGATVIGMSELAEMRRQAGALGPGPGAGAGESAGTRAAPADPSV
                     GRSASPAPASATLGVEAVDHEKPGALVVGVHVPGPGYAAGLVRGDVLLAFGTIRVDSAA
                     DLAHAVARARPGKAVKVTVRHESGGYQQLTAVPGVVT"
     gene            13149..14279
                     /locus_tag="SAM23877_RS27515"
                     /old_locus_tag="SAM23877_5790"
     CDS             13149..14279
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="SAM23877_RS27515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5790"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_053138931.1"
                     /transl_table=11
                     /translation="MTGSTPAAHFTADDYRARMERATRAAADAGLSGLLVAPGPDLVWL
                     TGYAPTAATERLTLLVLAPGQDPVLVVPTLEAPDAEKAVGAPALTLRDWTDGKDPYAAT
                     AALLADSGRFGISDNAWAMHLLALQRALPGTSYASLTEALPMLRAVKDAAELELLAAAG
                     AAADAAFEEIRTVRFGGRRESEVAADLAGLLRRFGHSQVDFTIVASGPNGANPHHEVGD
                     RVIEDGDMIVLDFGGLKDGYGSDTSRTVHVGEPTDEERRVHDLVREAQEAGFRAVRPGV
                     ACQEVDRAARAVIADGGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPG
                     VYLPGRFGVRIEDIVTVTEDGGRRLNDTTREMVTVE"
     gene            14356..15369
                     /locus_tag="SAM23877_RS27520"
                     /old_locus_tag="SAM23877_5791"
     CDS             14356..15369
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657040.1"
                     /locus_tag="SAM23877_RS27520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5791"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_053138934.1"
                     /sec_met_domain="APH (E-value: 1.1e-20, bitscore: 73.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLGGSAEPETVRPVAEGTASATWWVGT
                     RHVLRLAPDREAAVRQRRELRLRELIRPHLSVAVPKSVAHGEWAPGLTYTLDTRVPGGS
                     GEDHDVSALGEADLAALLGGLREVPARQAETLGVPRAAPRPLETLRQAAERAALRLARA
                     DEFDAARPERLTRAATAQLGAQSGAAVLVHHALAGEHLVVGADGRVRGVLGWTDAVLGD
                     PAEDIAALALSVGSPAAVRAATLAGYGARPCLRGLWLARCDALVHLAGALPGGPPTPPG
                     VSTRPLPLLRLRLRRAWEPILLERVTELREDGDGDGTDGPDGTVPGSDADDAGTGE"
     gene            complement(15442..17187)
                     /gene="treZ"
                     /locus_tag="SAM23877_RS27525"
                     /old_locus_tag="SAM23877_5792"
     CDS             complement(15442..17187)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445371.1"
                     /locus_tag="SAM23877_RS27525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5792"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_053138936.1"
                     /sec_met_domain="CBM_48 (E-value: 0.00015, bitscore: 20.7,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 3.9e-11, bitscore:
                     41.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVTLTCDGVTRAMERDPQRPGWWCGEAEARDGSR
                     YGFAVDDGPVLPDPRSRRQPDGPDGLSAVVDQGRYAWRAEWAGRPLPGAVLYELHVGTY
                     TPEGTLDAAAARLEHLAALGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHALGLGVVLDVVHNHLGPSGNYLPAFGPYFTDTHHTPWGVAVNLDAPGSDEVR
                     AYLVESALAWLRDYRLDGLRLDAVHALVDTRACHFLEELSTAVDGLAADLERPLFLIAE
                     SDLNDPRIITPRAAGGMGVHAQWNDDFHHALHTALTGESQGYYADFARDPLAALAKTLT
                     RGYFHDGTYSSFRGRGHGRELDRGRVAAHRLTGYGQTHDQIGNRARGDRLAALVSPGLA
                     ACAATLILTAPFTPMLFMGEEWAAGTPWQFFTDHTDPELAEAVRNGRRREFAAHGWRAE
                     DVPDPQDPATRERSCLDWSEPEREPHARVLDWYRRLIALRHERADLIAPDLADTRVAYD
                     ADARWLAFRRGDIRVAVNLGAEPVAIPLGGRPARVLAAWEPVEGPGADGVLRVPGESSV
                     VLVQE"
     gene            17362..17913
                     /locus_tag="SAM23877_RS27530"
                     /old_locus_tag="SAM23877_5793"
     CDS             17362..17913
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="SAM23877_RS27530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5793"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_053138939.1"
                     /transl_table=11
                     /translation="MTSSFEFNTYPARLSDAERDHALKVLRDGVVMGRLSHDTFIRRME
                     LALAARRLEELAALTADLPTEGRLSRMVFGTVEAVSGFGVRLRRAWQAERLPKLLLPHP
                     GTGHPLRIGRDPASGLRLTHETVSRVHAELSRQGGMWVLRDLSSTNGTTVNGRRVIGAA
                     VVREGDLIGFGQMAFRLATS"
     gene            18131..19456
                     /locus_tag="SAM23877_RS27535"
                     /old_locus_tag="SAM23877_5794"
     CDS             18131..19456
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445382.1"
                     /locus_tag="SAM23877_RS27535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5794"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_053138941.1"
                     /transl_table=11
                     /translation="MDELGTRAAALVARHPRQARLRRVGTSRAGTPLLLLSVGHGSRQA
                     LVVAGPHANEPVGGATVLRLAERALADPRLTEGADATWNLLLCADPDGLRRNEGWLSGP
                     YTLGRYARNFFRPGFLEQPEWLPDGPDHAALPETRALLTLQDELRPFLHCSLHGVDVGG
                     GFVELTHDLPGLAQRIAHAAARLGIPRELGAYDTLYWPDLGPAVYRIPPPRRGDLTAAI
                     TEAAVESTWCHPRRYGTVTAVVEAPMWGVAAVADGSPPADRDAVLRSVSRTLRHDTRRL
                     QRVLARIRPHLATDPDAAHLLAPVDDYLLVCPRLADAWDPDTDDGTGRSLPPMSTAHLV
                     ALRLAGRRLALRTAGLLHQLVTRTGDDPTGVLPELDRLVDEGCADYRDGCAARWIPVAR
                     QVEYQTRVVLSAFELAGRHSTAGARSGEPGWGSEAAVPMHLE"
     gene            19453..19911
                     /locus_tag="SAM23877_RS27540"
                     /old_locus_tag="SAM23877_5795"
     CDS             19453..19911
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142854.1"
                     /locus_tag="SAM23877_RS27540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5795"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_053138944.1"
                     /transl_table=11
                     /translation="MTHTLTAGAARAGLLAAAALLFTCAAPAHATAERRPAADWLLLTV
                     TPGDARAHAPGTRPGTGTGATRGALLLCDPPRGHAHAARACADLDATDGRIDAIPARDA
                     HCPMVHAPVTAHASGRWRGQPVDYTRTFPNACVLAASTGAVFAWDREG"
     gene            complement(19942..21345)
                     /gene="lpdA"
                     /locus_tag="SAM23877_RS27545"
                     /old_locus_tag="SAM23877_5796"
     CDS             complement(19942..21345)
                     /EC_number="1.8.1.4"
                     /GO_function="GO:0004148 - dihydrolipoyl dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /GO_process="GO:0051068 - dihydrolipoamide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="lpdA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034238.1"
                     /locus_tag="SAM23877_RS27545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5796"
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="WP_053138947.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-57, bitscore:
                     194.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTHDVIVIGGGTGGYSTALRAAALGLDTALVERDKVGGTCLHRG
                     CIPSKAMLHAAELVDGITEARERWGVEASLGGVDWPALVATRDDIVDRNHKGVEAHLAH
                     AGVRVVRGDARLTGARTVRVDGAHDLTARRGVVLATGSRPRTLPGLAPDGRHVVTSDDA
                     LFAPGLPASVLVLGAGAIGVEYASFHRSMGAEVTLVEAADRIVPLEDADVGRHLTRGLK
                     RRGVDVRVGARLADAEVLDDGVRARVHTSRGETVTIEAERLLVAVGRAPVTEGLDLAAA
                     GLETDRRGFVVPADWDRLETAVPGIHVVGDLLPPPSLGLAHASFAEGLLVAETLAGVPS
                     APVDYAAVPRVTYSAPQTAAVGLGEAEARARGYEVAVDVMPLTAVAKGMVHGQGGMVKV
                     VAEQGGGRVLGVHLVGPHVSEMIAESQLIVGWDAEPSDVARHIHAHPTLSEAVGEAFLT
                     LAGRALHRR"
     misc_feature    complement(21767..21781)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
ORIGIN
        1 tgcgggccgc cctggactgc gcggtgctct cgccgaccgg ctgggccgtc gccgtggacg
       61 ccgacggccg ggtgaccggc gtcgtctccc agcaggccgt cggtgaggcg atccgcgccg
      121 ctcacggtgc gggacccgcg gccgggacgc cggccgcacg gcccgccacc gccgccgtca
      181 ccgaggccgc cccgtgaacg gtttcttcga catcccgagc gacctcgaca acacctactt
      241 cgggctgatc ggactgcatc tgcgcgaggc gctgctgccg gtgctggccg ggctgctgct
      301 cgcgctgccc gtcgcccagc tctgcgtgcg gttccgctgg ctgtacccgc ccgtgctcgg
      361 cgtgaccacc gtcttctacg ccatcccgtc gctggcggtc ttcgtcgtcc tcatcgacta
      421 cacgggccag accgaactga cggtgatgat cccgctggcc gtctacagcc tggtggtgct
      481 cgtcccggcg atcgtcgacg gcgtgcggtc ggtgcccgag gagaccctcg ccgcgtccac
      541 cgccatgggc ttcggtcccg tacggcgcta cctccaggtg cagttgccga tcgccgtgcc
      601 cgccatcctc gccggcctcc gcgtggccgt gtcggcgagc atctcgctgg tcagcgtcgg
      661 cgccctcatc ggcaatcagg gcgccctcgg caatctcctc gcggacgccc agaagtacgg
      721 ccgtcccgaa ctggcggtga actccgtcct caccaccgcc gtactggcga tcctgtgcga
      781 cgcggcactc gtcctggtcc gcaacctgct gacgccgtgg atgccgcggg gcgggaccag
      841 gcgccccaag gcggccgccg tgcggcaggg ccggcccgag acggagaagg cggcggcccg
      901 gtgaacgtga tcaacttcgt caacgccttc ttcagcgaca gcgcccactg gcacggctac
      961 gacggcatcc cgcaacgcct gctggagcac gtccagtact cgctgctggc cctcggcctg
     1021 gccgccgcga tcgggctgcc cgccgggctg ctgaccgggc acaccggacg cggcggcaac
     1081 gcggtcgcct tcgtcgccac cgccgcccgc gcgctgccca gcttcggcct gctggtgctg
     1141 atcgccgtcg cggtcggcat cggcctgctg cccgtcatga tcccgctggt cgtgctcgcg
     1201 gtcccgccga tcctggtgac cacctacgag gcggtccgct ccgtcgaccc ctccccggtg
     1261 gacgccgccc ggggcatggg catgcacgag tcgagcatcc tgttccgggt cgaactgccc
     1321 gtcgccctgc cgctgatcct cagcggactg cgctcggcgg ccatccaggt cgtctcgacg
     1381 gccaccatcg ccgcgtacgt cagtctcggc gggatcggcc ggtacatcat cgacgggctc
     1441 taccagcgcg actacgagaa ggtggtcggc ggagccaccc tggtggcgct cctggccctc
     1501 gtcacgctcg cgttgttctg ggcggcggga cggctggcgg tctcgcccgg ggtgcgcagg
     1561 cgatgaccac ggagcgagat gtgcacacgg gtgtgaaaaa cgtgaccagg ccgttcttga
     1621 ctgaccgaca agtggctcgt ttggatcggt ggatgacttc taccgcgcac agcagcaggt
     1681 ccaggacgag gcacaccggc gcggcggccg tcgcgctcac cgccgcggcg gcgctgctcg
     1741 cgggctgttc ctcctccgac gacacctccg acaaccccct cgccggggag aaggcggagg
     1801 ccggcaccgt cgtcgtcggc tcgaacaact tcgccgagag caccctgctc gccgacatct
     1861 acggcgaggc gctcaaggcc aagggcctca aggtcaccta caagcacaac atcggcagcc
     1921 gcgagacgac gtacggcctg atgaagaacg gctcggtcac cgtgctgccc gagtacaacg
     1981 gctcgctgct ggcctacctc gactccaagg ccgagcagaa gtccgccgag gcggtgaacg
     2041 aggcggcgaa ggccgggctc gacgagaagc tgacgctgct ggaatcgtcg ccggccgaga
     2101 acaaggactc ggtcagcgtc aacgccgaga ccgcgaagaa gtacgggctc accgcggagt
     2161 cgaccctcgc cgacctgaag gaggtcgcgc cggacctggt gatcggcggc tcgcccgagt
     2221 tccagacccg gcagcagggg ctgaagggcc tggagtccgt gtacggcctg aagttcaagt
     2281 ccttcaaggc gctcgacgcg ggcggccccc tcacgcagtc ggcgctgacc aagaacaccg
     2341 tgcaggcggc ggacgtgttc accaccgacc cgaccatcat caaggagaag ttcgtcgtcc
     2401 tgaaggaccc ggagaacctc ttcggctacg cgaacgtgac cccgctggtg tacaaggagg
     2461 ggctctccga ggagggcgtc gccgcactga acgcggtctc cgccaagctg gacaccaaga
     2521 cgctcctcga cctggacgcc caggtgcagc tggacaagaa ggacccgctg gacgtggcca
     2581 aggaatggct cgcgtcggcc ggactggtct gacgctccgg tcccggccgc cgtcacggcg
     2641 ccgcggcccc ggccgcggcg tcgatcagct ggtcgatcag cgcgacgagg acgtcccggc
     2701 aggaggcccg gtcccgcgcg tcgcacagca gcacctgcac gtgcgccggc agcgccagcg
     2761 cctcccggat cgcctcggcc ggatacggat gccgcccgtg gaagccgttg acgccgacga
     2821 cgaacgggat gccccgccgc tcgaagaagt cgatggccgc gaagctcgac tcgggtctgc
     2881 ggacgtcgac caggaccacg gcgccgaggg cgccgatcgc caggtcgttc cacatgaacc
     2941 agaaccgctg ctgcccgggg gtgccgaaga ggtacagcac cagttcccgg ccgatgctga
     3001 tccggccgaa gtccagggcc acggtcgtgg cccgcttctc ctcgatgccg gcgaggtcgt
     3061 ccacgtccag tcccgccgcg gtcagcggtt cctcggtgcg cagcggggcg atctcgctca
     3121 ccgatccgac catggtggtc ttgccgacgc cgaaaccccc ggcgatcagg atcttcacgg
     3181 cgtcgggtgc ggcggcccgg ggcgcgggtg ccgtgggcgc cggagcggtg cggtcagagc
     3241 cggccaaggc cgtccctcac tttctgcagc aggtccaggt ccgggttggc gcgggagacg
     3301 aggtgcggcg gccgggcggt gatccggccc gcctccagca ggtcgcagag caggatcacg
     3361 accacgctca ccggcaggtc gaggcgggcc gctatctccg cgacggcgac gggctcggcg
     3421 cacaggcgca ggatgcgcag gtgctcgggc tgcggtcgcg cggcccgcga gggctgtggg
     3481 tcgaccgcgg tcaccgtcgt gatgagggtg aagtcggcgc ggctgggccg ggtccggccg
     3541 ccggtcaggg tgaacggccg caccagccgg ccccccgcgt cgcctccggt cacgtcactc
     3601 gccggggccg gcggtggccc gcggtgccgc gctcaggtgc tcgccgatct tcttcaccag
     3661 catgttcatc tggtacgcca cgacaccgac gtcggcgttc gggccggtga ggacgaccag
     3721 gtgggcgccc gggcccgccg aggtgagtat caggtagctg ttggccatct cgatgagggc
     3781 ctggcgcacc gggccgccgc ggaagtccat gctgacgccc ttgctcaggc tcatcaggcc
     3841 cgacgcggtc gccgccagcc gctcggcgtc gtcgcgcagg aaaccggtgg acttgctgac
     3901 gaccagtccg tcctcggaga gcaccaccgc ctggctcacg tcggcgaccc gctccacgag
     3961 tccggtgagc agctggtcca gctcggtgtg cgtggcgggg gagggtcggg tcatggcttg
     4021 tccttcgtcg gcggtcgtcg gtcggcggtc ggggtcgggg gcgcggcgca ggagagagcc
     4081 tgctcggcgg cgggggtgtc ggcgggttcc gcgtcgacgg cggtgtcccc gtccgtgccg
     4141 gcggcctgcg cccgcagcgt gccgcgctgg aaaccggcga gggacgcggc ggcgcgctcg
     4201 gcggtgaagg cggcgtggtc ctccgcggcg gcgtccgggc cgtcctggcc ggtgacgggg
     4261 ccctcgtcac ggagctcggc ggccaggctc gtctgcggca cccggcgggg cagcggggcg
     4321 agcccgtcgg cctcggtggc ggtggcggcc ggagccgggg ccgggcgcgc cgccggggaa
     4381 ggccgcttca ccgggagggg acggccctcc ccggccgcgg ccgagacgcg cacgagggcc
     4441 tcgggggcat cgggggcctc gggggcctcg ggggccggcg gtgcgccgtc ggcaccggca
     4501 cccccctcca caggctccgg caccacgatg tcgtgcggga tgagcacgat ggcggtggtc
     4561 ccgccgtacg gggaggagcg cagcgtcacg gtgatgccgt gccggtgggc gagccgggcg
     4621 acgacgaaca tgccgagccg caggtcgtcc gcgagcgcca cgacgtcgaa ctgcggggcc
     4681 acggcgagct gggcgttgaa cgaggcgtag tcctcctccg acaggcccag tccacggtcc
     4741 tcgatctcga cggccaggcc cttggcgacc atcgcggccc gcaccccgac cggctggggg
     4801 gcgggggagt acgcggtggc gttgtcgatg agttcggcga gcaggtggat cacgtcggcc
     4861 accgcgggcg gggcgagggc cacctcctcg tcggtgtgca gctccacccg ctggtactcg
     4921 gcgacctcgc cgaccgcgct gcgcaggatg tcgaccagcg cgacgggctc gcgccaggtg
     4981 cgccgtggct gctcaccact gatgatcacg aggttctcct cgtaccggcg caactggctc
     5041 gcggtggagt ccagttcgta gaggcccttg aggatctcgg ggtcggtgtg ctcgcgctcc
     5101 agcgcgtcca gcttgccgag ctgcatgttg acgaggttct ggctctgccg ggcgatgccc
     5161 aggatcacct tctggaagcc gcgccgggtg tcggcgagtt cgacggcggt gtgcacggcg
     5221 gtgcgctgcg ccgcgttgaa cgcttgcgcc acctggccga gttcgtcgcg cccgtagtcc
     5281 agcggcgggg tcgccgactc cacgtcgacc ttctcgcccc gctccagccg ggccaccacc
     5341 tcgggcagcc gctcctcggc caggctcagg gtggccagcc gcagcccgcg cagccggcgg
     5401 gagagcgagc gggtgatgcg ccaggacatg ccgacgcaca gcagcagggc gaccaggccg
     5461 cccgcgctga gggaggccgc ggtgatcagc agtccgcgcg cctcgtcggc gctgcggtcg
     5521 agcaggccgt ccgtctgctg ccggatcagc gccgcgtact ggtcggagac ctcgtccagg
     5581 gcggtcgtcc agcgctgccg cacgtccggc aggtcgatcc ggccctcccc gcccgccgcg
     5641 cgggccgcga gcacctggtc ctcgacggac tgcagggccg cccactccgg gctcgcgagg
     5701 atccgctcgg tctgcgcctt cgcctcgccc cgcagggagg ggaggatctg gtcctggacc
     5761 agccagcgcc gggtgtggac cagctgggcg aactccgccc actcctcctc gcccatccgg
     5821 tcggacggcc aggccagggt gagccgggcg tcctcctggg acaccagttc cgcggcgtgc
     5881 tccagggcga ccagtggtcc ggcctgcgag gtgaggtcgc cgtcgtcgac ctgggagagt
     5941 tcctggaagg cgtggatctg ctcgtcgatg atcgacgtgt actggtcgag tgcctggtcg
     6001 gcggtgatgt cgctgggctc gtcgacctgg tcgcggtagt actccaggct gcccaccgag
     6061 ccgagcaccg agtacagccg ctccgagacc cggtcgggcg cgcgctcgat cgcgtcggac
     6121 cggccgacca gttgggccac cgccgcgtcc gtcctccgcc gctgggcgtc caggtcggta
     6181 cggtcgccgc cgggtcccgc cagccacgcc gccgacaggc tgcgctcctt ctggagcgcg
     6241 agcgccgcct cggtgcccat ggccccggtg gaccggctga gctccgtctg cgcccgcagt
     6301 cgcaggccct cggagaacat ctggatcgtc gtcacccccc acaccgtggc gagggtgacg
     6361 cccgggacca gggccaggag gatcagggag agacgtatgg agccgaggcg gcgccgggca
     6421 cccgtccgtg cagacatcgt cgtcctaggc gatcagtggg gaaggcggtc aagtgcgcgc
     6481 gggcgcgtgc ggtcgcgggg gccggtcacc gggtgccgcc cgcggcgaag cgcgcgaccg
     6541 cgtcggcgtt cgtccgggtc acgaaggccg ggccggtcag gacgggcgcc actccgccgc
     6601 cactgacgtt gccgttggtg cggtagagcc agagcgcgtc caccgcgagg tagccttgca
     6661 gatacggctg ctggtccacc gcgaactgca cgtcgccccg cttgaccgcg gcgaccaggt
     6721 cctcgtccag gtcgaaggtg gcgacctggg ccctgctgcc cgccttggcc actgcctcga
     6781 ccgcggtgag ggcgaaggcc gcgccgttca tgacgacctc gtcgatgctg gagtcctgcc
     6841 gcagccgcgc ggtgacggcc gcgcccaccg ccttcatgtc ggtgccctcg acgtagagca
     6901 tctcggtctc gccgccgaag gtcttcttca caccggcgca gcgggcctcc agggcgacgt
     6961 tgccccgctc gtggatgacg cacagggcgt gccgggcccg caggtcgttc agcttgtcgc
     7021 cgacggcccg gcccgcgacg ctctcgtcct ggccgaagta ctggaggagc ccggtcggcc
     7081 gccaggcgtc gataccggag ttgaggccga cgacggggat gccggccgcc tccgcctcgg
     7141 cgaccggccc cttcatcgcc tgcggtttgg cgagggtcac ggcgatgccg tcggccttct
     7201 cgcggatcgc gtcccgcacc aggtcggcct ggtcggcggt gtcggcgtca ccggcgtacg
     7261 tgaggtcgac gccgtccttc gcggcggccg cctcggcgcc cttgcgcacc cggtcccaga
     7321 aggcgtcgcc ctccccaccg tgggtgacca tgacgatctt catccggtcg ccgccggccc
     7381 cggccgcggc gtcggcggcc gagccgtcct cgtccgcgcc gagggcggag cagccggccg
     7441 ccagcaggca gacggccgcg gcgagggcgg cggcgcgcag gcgtccgggc gtgggggtgg
     7501 gcgggggaga agtactcatg ggggttgcgg cacctcgctg tgcggccgag caggaggaac
     7561 ggagcgaggg gggccggagc cgcgtgacgg tgcgccaacc gggtgaatct cgcctggccg
     7621 gagcaaaccg tgtgtgacgg ccggtagtca agtgacccgc gacctgccac cagttgtcgg
     7681 tgccgcatcg tgatgaacgg gacgggtgaa gcgagagtga cgggagagga cgctcgacgg
     7741 cctccgcccc ggccctgtcc cccgtggcgg cgcgacgggc ggtgccgctc gtgccacggg
     7801 ggcgcgggaa cgtgcacctg acggtgcgtt atcttgtacg gggggttaag acaggcggca
     7861 cggcctgttg agttccagcc cgggagagtc cagccgatgg cgaggcagct acgcgccgaa
     7921 cagacccgcg cgacgatcct cggggccgcc gccgaactgt tcgaccgtca aggctacgag
     7981 tcgaccagcc tgagcgagat cgtggcccac gccggagtca ccaagggcgc cctctacttc
     8041 cacttcgcgg cgaaagagga cctcgcccac gccatcatgg agctccagtc cctcacgtcg
     8101 cgcaggctgg cggccgagct ggacggcagg gggtacacct ccctggaggc cctgatgcgc
     8161 ctcaccttcg acatggcccg gctgtgcgag gaggggccgg tgctgcgcgc cggtctgcgg
     8221 ctcgccaccg ggggagtggc agtgcggccg ccgctgccgc accccttcac cgagtggcgt
     8281 gagatcgcct cgtcccgcct cctggacgcc gtccggcagt ccgacgtgca cccggacatc
     8341 gacgtcgact ccgtcgccca cacgctcgtc tgctccatcg tcggcacgcg ggtcgtgggc
     8401 ggcaccctgg agcccgacgc gcggcagccg cgccgcctgg ccgggatgtg gcgcctcctc
     8461 atccggggca tggtgccggt cacccgacgc gcgcgctacc tcaccctggc ggcccgcctg
     8521 gagcgggaac tgagcaccgc ctgacccccg tcgggggccc ggggcccggg gcccgggggc
     8581 cgggggccgg gggccggggg cccgaggcgc ggggacgggc gtccggttcc gtcgccgtgc
     8641 cccggccgcg cgatacggtg aggcgcatgc ccgacacccc gccggagccc gccccggtca
     8701 tcctcggcga cgagccgggg tccttccccc acagcgtgct ggccgagcgc cacccggcca
     8761 tcctccgcca ggtgggcgag gcgttcccct acgaccccga gcggcgggcc ggcctcgacg
     8821 cgctgctcgc gagctgtgcc gacggtgcga tcgagccgct gcccgacgcg gccgaccccg
     8881 cggaccggcg ccgctgggcg gaatggggga cggaccggta cgccggccgc tcctggttcg
     8941 acgtgccctg gctgtgggcc gagagccact tctaccgtcg gctcctcgac gccgtcggat
     9001 acttcggccc cggcccctgg cagggcgtcg acccgttccg gcccgccaaa ctcgccgagc
     9061 tcgggtcccc ggagacggac gaggaactgg ccgcactcga cgacctcgcc ggcctgcccg
     9121 ccgaggagcg gacccgggcc ctgctgcacg gctcgctctg gggcaaccgc gcggacctgg
     9181 gcttccgcct ctccgggaac ggcgcccgca ccgaggaccg ggtgcgggca ctggtcgccg
     9241 acgacagtga cgtgctgtgg tcgctgctcc cgccctccgc gcccggcacc ccggtcccgg
     9301 ccaccctgtg cctcgtcgcc gacaacgcgg gccgcgaact cgtccccgac ctgctgctcg
     9361 tcgcccacct cctcgccgag ggccgcatcg gacgggcggt cctgcacgtc aagccgcacc
     9421 cgtactacgt ctccgacgcc acccccgccg acgtgctcga cgcgctgcga cgcctggtgg
     9481 cggcgggcgg agcggccgcc tcctacggcg agggcctgtg gaccgcactg accgacggcc
     9541 gcgtcaccgt ccgcgtccac cccttctcct gcgccccgtt gccgtacgcg gacatgcccg
     9601 gcgacctgcg cgcggagttc gcctcggcca cggtcaccgt cctcaagggc gacctcaact
     9661 accgtcgtct ggtgggtgac cggtactggc ccccgaccac gcccttcgcg gatgtgaccg
     9721 gctacttccc cggccccgtc gccgcactgc gcaccctgaa gtccgacgtg atcaccggcc
     9781 tgaccgcgcg gacggaggcc gcgctggagg cgagcgggga acggcgctgg cggacgagcg
     9841 ggacccacgc gctgatccag gtcaggggct gagcccgcgg cgcccgggcc cgggcaggac
     9901 ggaccgccga aagttcccgc ccttcgcccc gattcacgcg atggtgtgat catgtgccgc
     9961 gccgcggatg tgcccgcggg gccatgggta gtgcccggcc atgacgcaac agcccttcga
    10021 actcccgcac ttctacctgc cgcatcccgc ccggctcaac ccgcatctcg acgaggcccg
    10081 cgcccactcg acgacgtggg cgcgcgagat gggcatgctg gagggttccg gggtctggga
    10141 gcagtccgac ctcgacgcgc acgactacgg cctgctctgc gcctacaccc accccgactg
    10201 cgacggcccg gcgctctccc tcatcaccga ctggtacgtg tgggtcttct tcttcgacga
    10261 ccacttcctg gagaagttca agcgcaccca ggaccgcgtc ggcggcaaga cccatctcga
    10321 ccggctctcc ctgttcatgc cgctcgacct cgccgccggg atgcccgagc cggagaatcc
    10381 ggtggaggcc ggcctcgccg acctgtggac gcgcacggtg ccggcgatgt cggccgagtg
    10441 gcgccgccgc ttcgccgtcg ccaccgagca cctgctcaac gagtccctgt gggagctgtc
    10501 caacatcaac gaggggcgga tcgccaaccc cgtcgagtac atcgagatgc gccgcaaggt
    10561 cggcggcgcc ccctggtcgg cggggctggt cgagtacgcg accgccgagg tgcccaccgc
    10621 cgtcgccggc tcccggccgc tgagggtgct gatggagacg ttctccgacg ccgtgcacct
    10681 gcgcaacgac ctcttctcct accagcgcga ggtcgaggac gagggggagc tgagcaacgg
    10741 ggtgctggtc ctggagacct tcttcggctg caccacccag gaggccgccg agctggtcaa
    10801 cgacgtcctc acctcccggc tgcaccagtt cgagcacacg gcgttcaccg aagtgcccgc
    10861 ggtggcactg gagaacggcc tgtcgccggc cgaggtcgcc gccgtcgggg cgtacgcgaa
    10921 gggcctccag gactggcagt ccggcggcca cgagtggcac atgcgctcca gccggtacat
    10981 gaacaagggc gcccggcccg ccgccggctg gcaggcgctg accggccccg gcacctccgc
    11041 cgcggacgtc ggcgcgctgc tgaccgcggc tgccgccgga cggaggcgtc cctacaccta
    11101 tgtgccgttc cagaaggtcg gcccctcggt catccccgac atccgcatgc ccttcccact
    11161 ggagctgagc ccggccctgg agggcgcccg acggcacctg tccgaatggt gccgggcgat
    11221 gggcatcctc agcgaggggg tatgggacca ggacaagctc gcgagctgcg acctgcccct
    11281 gtgcgccgcg ggcctggacc cggacgccac ccaggagcag ctggacctcg cctccggctg
    11341 gctggccttc ggcacctacg gcgacgacta ctacccgctg gtctacggcc accgccgtga
    11401 cctggccgcc gcccggctga ccacggcccg gctgtcggcc tgcatgccgc tcgacggcga
    11461 gccggtcccg ccgccggcca acgccatgga acgctccctg atcgacctgt ggacccgcac
    11521 gaccgccggc atgacgcccg gccagcggcg cccgctgaag acggccgtgg acaagatgac
    11581 cgaggcctgg gtgtgggagc tggccaacca gatccagaac cgcgtccccg acccggtgga
    11641 ctacctggag atgcggcgcg ccaccttcgg ctccgacctc acgctgggcc tgtgccgtgc
    11701 cggacacggc ccggccgttc cgcccgaggt ctaccgcagc gggcccgtcc gttccctgga
    11761 gaacgcggcg atcgactacg cgtgcctgct caacgacgtc ttctcgtacc agaaggagat
    11821 cgagtacgag ggcgagatcc acaacgcgat cctcgtcgtg cagaacttct tcggcgtcga
    11881 ctatccggcc gcgctcaccg tcgtgcagga cctgatgaac cagcgcatgc gccagttcga
    11941 gcacgtcgtc gcgcacgaac tgccggtcgt gtacgacgac ttccggctga gcgacgaggc
    12001 gcgcggcgtc atggcgggct atgtgaccga cctgcagaac tggatggcgg gcatcctcaa
    12061 ctggcatcgg gaggtgccgc ggtacaaggc cgactacctg gcccggcgca cccacggctt
    12121 cctcccggac cggatcccgg ccgtacccgt gcccaggctc agcaccgtgc cgacggcctg
    12181 accgacgtcc agtctcactc tttcgtggct cgtcacgcgc tggtgcgccg ggtagagcac
    12241 cagccggagg cgatcgatgg aacagacagc gttgcgaccc aagccgatgc ccggccggga
    12301 accccgagcc ggtgccgcgc ccgccgacgt ccggcgtccg cacaccgggc gtcggcgccg
    12361 ccgacggctc accaccgtgt tgctcggcgt gtgcgccgcc acggccctgc tgctggcggg
    12421 cgtgggactc ggcacggtgg gggccacggt catcggcatg agcgagctgg ccgagatgcg
    12481 acggcaggcg ggtgcgctcg gaccgggacc gggagcggga gcgggcgagt cggcgggcac
    12541 ccgggccgct ccggcggacc cgtcggtcgg ccggtccgcc tccccggccc cggccagcgc
    12601 gaccctcggc gtggaggccg tggaccacga gaagccgggg gccctggtgg tgggtgtcca
    12661 cgtgcccggc cccgggtacg cggccggcct ggtccggggc gacgtgctcc tggccttcgg
    12721 cacgatccgc gtcgactcgg ccgccgacct cgcgcatgcc gtggcccgcg cccggccggg
    12781 caaggcggtc aaggtcacgg tgcgccacga gagcggcggt taccagcagc tgacggccgt
    12841 accgggcgtc gtcacctgac ccgtccgaac cgattcgccg gcccgcgccc ctgctcgccc
    12901 ttcccggacg gccgagcacc ccgtgccgcc cggcggacac cggacccgca ccggtcacct
    12961 ccggggcgct cggaccacac gcgcacggcg ccggggcgtc cgagggaccg gacggcacgc
    13021 cccggcggcc gtgaggcgtc tcccgttcca ccagtggtgc gggtttccgt gcaaatcggc
    13081 tcgcgtcact cccgcgccga gggcaggatg ctgctcacag ccccaccctc gtcgcccagg
    13141 aggcccggat gaccggcagc acgcccgctg ctcacttcac cgccgacgac taccgggccc
    13201 gcatggagcg cgccacccgg gcggccgccg acgcgggcct gtccgggttg ctggtggcgc
    13261 cgggaccgga cctcgtttgg ctcaccggct acgcgcccac cgcggccacc gaacggctca
    13321 ccctgctcgt cctcgccccc ggccaggacc ccgtcctggt cgtgccgacg ctggaggccc
    13381 ccgacgcgga gaaggccgtc ggcgcgcccg ccctgaccct gcgcgactgg accgacggca
    13441 aggaccccta cgccgccacc gccgccctcc tcgcggactc cgggcggttc ggcatcagtg
    13501 acaacgcctg ggcgatgcac ctgctggccc tccagcgggc gctgcccggc acctcgtacg
    13561 cctccctcac cgaggcgctg cccatgctgc gggccgtcaa ggacgcggcc gaactggaac
    13621 tgctggccgc ggcgggcgcc gccgcggacg ccgcgttcga ggagatccgc acggtccgct
    13681 tcggcgggcg ccgggagtcc gaggtcgccg ccgacctcgc cggtctgctg cggcggttcg
    13741 ggcactccca ggtcgacttc accatcgtcg cctccggccc gaacggcgcc aacccgcacc
    13801 acgaggtcgg cgaccgcgtc atcgaggacg gcgacatgat cgtcctcgac ttcggcggcc
    13861 tgaaggacgg gtacggctcc gacacctccc gcaccgtcca cgtgggcgag cccaccgacg
    13921 aggagcgccg ggtgcacgac ctcgtccgcg aggcccagga ggccggattc cgggcggtgc
    13981 ggcccggtgt cgcctgccag gaggtggacc gggccgcccg cgcggtcatc gccgacggcg
    14041 ggtacggcga gtacttcatc caccgcaccg ggcacggcat cggcgtcacc acgcacgagc
    14101 cgccgtacat gatcgagggg gaggaacagc ccctcgtgcc cgggatgtgc ttctccgtcg
    14161 agcccggcgt ctatctgccc ggccggttcg gggtacgcat cgaggacatc gtcacggtca
    14221 ccgaggacgg tggccgccgc ctcaacgaca ccacgcggga gatggtcacg gtggagtgac
    14281 cggcgaccga gagaccccga aacgccccgg cgcgacctga acgcccgggc agacccggaa
    14341 gacgacggcg cgaccatgac ccaggcaccg acacccaccg cggacaccgt ccgtcgactg
    14401 gtccgttccc tgctgggcgg cagcgcggaa cccgagaccg tccggccggt cgcggagggc
    14461 accgcgtccg ccacctggtg ggtcggcacc cggcacgtgc tccggctggc gcccgaccgc
    14521 gaggccgcgg tgcggcagcg acgcgagctg cggctgcgcg agctgatccg cccgcacctg
    14581 tccgtcgcgg tgccgaagag cgtggcgcac ggcgagtggg cgccgggcct gacctacacg
    14641 ctggacacca gggtgcccgg cggatcgggt gaggatcacg acgtgtcggc cctgggggag
    14701 gcggacctgg cggcgctgct cggcgggctg cgcgaggtgc ccgcccgcca ggcggagacc
    14761 ctcggtgtgc cccgggccgc cccgcgcccg ctggagacgc tgcggcaggc cgccgagcgc
    14821 gccgccctac gcctcgctcg ggccgacgag ttcgacgccg cgcgtccgga gcggctgacc
    14881 cgggcggcga cggcccagtt gggcgcccag agcggcgcgg ccgtcctcgt ccaccacgcg
    14941 ctggccgggg agcacctcgt ggtcggcgcc gacggccggg tgcgcggtgt cctcggctgg
    15001 accgacgcgg tcctcggcga cccggccgag gacatcgccg ccctcgcgct gtccgtcggc
    15061 tcgcccgccg ccgtccgcgc cgccaccctc gccggctacg gcgcccgccc ctgcctgcgc
    15121 ggcctgtggc tggcccgctg cgacgccctc gtccacctcg ccggcgccct gccgggcggg
    15181 ccgccgacgc cgccgggcgt gagcacgcgg cccctgcccc tgctcaggct ccgcctgcgg
    15241 cgtgcctggg agccgatcct gctggaacgg gtgacggagc tgcgggaaga cggcgacggc
    15301 gacggcacgg acggaccgga cggcaccgtc ccggggagtg acgcggacga cgccggcacc
    15361 ggggagtgac ggggggcggc tccccggcac cggcactgac acggggcagc gcccgcaccg
    15421 cggagtgacg cggacggcgc ctcactcctg cacgagcacc acgctcgact caccgggcac
    15481 ccgcagcacc ccgtccgcgc ccggcccctc cacgggctcc cacgcggcga gcacacgggc
    15541 ggggcggcct ccgaggggga tcgccaccgg ctcggcgccg aggttgacgg ccacccggat
    15601 gtcaccgcgc cggaaggcca gccagcgcgc gtcggcgtcg taggccaccc tggtgtcggc
    15661 caggtccgga gcgatcaggt ccgcccgctc gtgccgcagg gcgatcagcc ggcggtacca
    15721 gtccagtacg cgcgcgtgcg gctcgcgttc cggttcggac cagtcgaggc aggagcgctc
    15781 gcgcgtcgcc gggtcctggg ggtcgggcac gtcctccgcc cgccagccgt gggcggcgaa
    15841 ctcccggcgc ctgccgttgc gcaccgcctc ggcgagttcc gggtcggtgt ggtcggtgaa
    15901 gaactgccac ggggtgccgg cggcccactc ctcgcccatg aacagcatcg gcgtgaacgg
    15961 cgcggtcagg atgagcgtgg ccgcacaggc cgccagaccg ggggagacca gcgcggccag
    16021 ccggtcgccc cgggcgcggt tgccgatctg gtcgtgggtc tggccgtacc cggtcagccg
    16081 gtgcgcggcc acgcggcccc ggtccagctc ccggccgtga ccccggcccc ggaagctgga
    16141 gtaggtgccg tcgtggaagt agccccgggt cagcgtcttg gccagcgccg ccagcggatc
    16201 ccgcgcgaag tcggcgtagt agccctgcga ctccccggtc agcgcggtgt gcagggcatg
    16261 gtggaagtcg tcgttccact gcgcgtgcac ccccatgccg cccgccgcgc gcggggtgat
    16321 gatccgcggg tcgttgaggt cggactcggc gatgaggaac agcggtcgct ccaggtcggc
    16381 ggcgaggccg tccacggcgg tcgacagttc ctccaggaag tggcacgcgc gggtgtcgac
    16441 cagggcgtgc acggcgtcca ggcgcaggcc gtcgagccgg tagtccctga gccaggccag
    16501 ggcgctctcc accagatagg cgcgcacctc gtccgagccg ggggcgtcca ggttgacggc
    16561 gacgccccag ggcgtgtggt gggtgtcggt gaagtacggg ccgaaggcgg gcaggtagtt
    16621 gccggagggg cccagatggt tgtgcaccac gtccaggacc acgccgaggc ccagtgcgtg
    16681 ggctcggtcg acgaaccgtt tcagcgcctc gggcccgccg tacggctcgt gcaccgccca
    16741 cagcgagaca ccctcgtacc cccagccgtg ccggcccggg aaggggcaca gcggcatcaa
    16801 ctccacgtgc gtgacgccca gtgcggccag atgctccagc cgcgcggcgg cggcgtccag
    16861 cgtgccctcg ggcgtgtacg tgcccacgtg cagctcgtac aggacggcgc cgggcagcgg
    16921 acgcccggcc cactcggcac gccacgcgta ccgcccctgg tcgacgaccg cgctcagtcc
    16981 gtccggcccg tccggctgcc tgcgcgatcg cgggtccggc agcaccggcc cgtcgtccac
    17041 cgcgaagccg taccgcgagc cgtcgcgcgc ctcggcctcc ccgcaccacc accccggccg
    17101 ctgcggatcg cgctccatcg cgcgcgtgac gccgtcgcac gtcaacgtca cccggtcggc
    17161 ctgtggtgcc cacacctcga actgcacgga cggttcccct tcgtctgctc accgtgatgt
    17221 agcccgtcca tggtcctgca aaagcgatct ccccgctggg gaaaaccgcc gttcgcggca
    17281 ggtgtcgtac cgcaccgcgc gcagggtggc cgtttctccg ttttctggac accccggccc
    17341 ggctgaccga caatcacctg cgtgacgtcg tccttcgagt tcaacacgta ccccgcgcgg
    17401 ttgtccgacg cggagcgcga ccatgcgttg aaggtgctcc gggacggcgt cgtcatgggg
    17461 cgcctgtcgc acgacacgtt catccgcagg atggagctgg cgctcgccgc ccgccgcctg
    17521 gaggagctcg ccgcgctcac cgccgacctg cccaccgagg gccggctgtc gcggatggtc
    17581 ttcggcaccg tcgaggccgt gtccggcttc ggcgtacgcc tgcgcagggc ctggcaggcc
    17641 gagcggctgc ccaagttgct gctgccccac cccggcaccg gtcatcccct gcgcataggg
    17701 cgcgacccgg cgagcggtct gcggctcacc cacgagacgg tctcccgcgt acacgccgaa
    17761 ctgagccgtc agggcggcat gtgggtgctg cgcgatctga gctccaccaa cgggaccacg
    17821 gtcaacggcc ggcgggtcat cggggcggcg gtcgtccgcg agggcgacct gatcggtttc
    17881 ggccagatgg ccttccgtct cgcgacgagc tgaccccgag gaaggggggt cgaagcccag
    17941 ctctggcctg ggcctcactc ggagtcgcgc attccggtgg agtgagccga tggcgcaaac
    18001 ccctttgcct gtcgcggtgt tgacgttccc cccaagacgt gactgactgt gcgtacaccg
    18061 cgcacgccag gtgaaccgac ggaccgcatc atggaggtgt gccctgccgc ccctcctgcg
    18121 ctacccgacc gtggacgagc tgggcacccg ggccgccgcg ctcgtcgccc gccatccccg
    18181 gcaggcccgc ctgcgccgcg tcggcacgtc ccgcgcgggc accccgctgc tgctgctctc
    18241 cgtcggccac ggcagccgcc aggccctcgt cgtcgccgga ccgcacgcca acgaaccggt
    18301 gggcggcgcc accgtcctgc ggctcgccga gcgggccctg gcggaccccc ggctcaccga
    18361 gggcgcggac gccacctgga acctgctcct gtgcgccgac cccgacggcc tgcgccgcaa
    18421 cgagggctgg ctgtccggcc cgtacaccct cggccggtac gcccggaact tcttccggcc
    18481 gggcttcctg gagcagcccg agtggctgcc cgacggcccg gaccacgccg cgctgccgga
    18541 gacccgcgcc ctgctcaccc tccaggacga gctccggccc ttcctgcact gctccctgca
    18601 cggcgtcgac gtgggcggcg gtttcgtcga gctgacccac gacctgcccg gcctcgccca
    18661 gcgcatcgcc cacgccgcgg cccggctcgg catcccccgc gagctcggcg cctacgacac
    18721 cctgtactgg cccgatctcg gtcccgccgt ctaccgcatc ccaccgcccc gccgcggcga
    18781 cctcaccgcg gccatcaccg aggccgccgt cgagtccacc tggtgccacc cccggcggta
    18841 cggaaccgtc accgcggtcg tcgaggcgcc catgtggggc gtggccgccg tcgcggacgg
    18901 ctcacccccg gccgaccggg acgcggtgct gcgctccgtg agccgcaccc tgcgccacga
    18961 cacccgtcgg ctgcagcgcg tcctcgcccg catccggccc cacctcgcca ccgacccgga
    19021 cgcggcccac ctgctcgccc ccgtcgacga ctacctgctg gtctgcccca ggctcgccga
    19081 cgcgtgggac cccgacaccg acgacggaac gggccggtcc ctcccgccga tgagcaccgc
    19141 ccacctggtc gccctgcgcc tggccggccg gcgactggcc ctgcggaccg cggggctgct
    19201 gcaccagctg gtgacccgga ccggggacga tccgacgggt gtcctgcccg agctggaccg
    19261 gctcgtcgac gagggatgcg ccgactaccg tgacggctgc gcggcccgct ggattccggt
    19321 cgcgcgccag gtggagtacc agacgcgggt cgtgctctcc gcgttcgaac tggccgggcg
    19381 gcactccacc gcgggtgccc gttcgggtga gccgggctgg ggttccgagg ccgccgtgcc
    19441 gatgcacctg gaatgaccca caccctcacg gcgggagcgg cgcgggccgg tctcctggct
    19501 gccgcggccc tcctgttcac ctgtgcggca ccggcccacg ccaccgcgga gcggcggccg
    19561 gcggccgact ggctgctcct caccgtcacc cccggcgacg cccgggcgca cgcccccggt
    19621 acccggccgg gtaccggaac cggcgccacg cgcggtgccc tgctgctgtg cgacccgccc
    19681 cggggccacg cccacgcggc ccgtgcctgc gcggacctcg acgcgacgga cggccgcatc
    19741 gacgccatcc cggcgcgcga cgcccactgc ccgatggtcc acgccccggt caccgcccac
    19801 gcgagcggcc ggtggcgcgg acaaccggtg gactacacgc ggaccttccc gaacgcgtgc
    19861 gtgctggcgg ccagtacggg ggccgtgttc gcgtgggacc gggaggggtg atcacaccgg
    19921 gccggtgacc ggccgggcgc gtcaccgccg gtgcagtgcg cggccggcca gcgtgaggaa
    19981 cgcctcgccg accgcctccg acagggtggg atgggcgtgg atgtggcggg cgacgtcgga
    20041 cggttcggcg tcccagccga cgatcagctg gctctcggcg atcatctccg agacgtgcgg
    20101 gcccaccagg tggactccga gcaccctgcc gcccccctgc tcggcgacca ccttcaccat
    20161 cccgccctgc ccgtgcacca tccccttggc gaccgcggtc aacggcatga cgtcgacggc
    20221 gacctcgtac ccccgcgcgc gtgcctccgc ctcgcccagg cccacggccg cggtctgcgg
    20281 cgccgagtac gtcacccggg gcacggccgc gtagtcgacg ggcgcggacg gcacacccgc
    20341 cagcgtctcg gccaccagca ggccctcggc gaacgacgcg tgggccagcc cgagggacgg
    20401 cggcggcagc agatcgccca ccacgtggat tccgggcacc gccgtctcca gccggtccca
    20461 gtcggccggt acgacgaatc cccgccggtc ggtctccagc cccgcggcgg ccaggtccag
    20521 cccctcggtg accggcgccc gtcccacggc caccaggagc cgttcggcct cgatcgtgac
    20581 cgtctccccg cgcgaggtgt gcacccgcgc gcgcacgccg tcgtcgagca cctcggcgtc
    20641 cgccagccgg gcgcccaccc gcacgtcgac gccgcgcctc ttcagaccgc gcgtcagatg
    20701 gcggccgacg tccgcgtcct ccagcggcac gatccggtcg gcggcctcca cgagggtcac
    20761 ctccgcgccc atcgagcggt ggaacgaggc gtactcgaca ccgatcgccc cagcgccgag
    20821 gaccaggacc gacgccggca gcccgggggc gaacagcgcg tcgtcgctgg tcaccacgtg
    20881 tcggccgtcc ggcgcgagcc cggggagcgt gcgcgggcgt gagccggtcg ccagcacgac
    20941 gccgcggcgt gcggtgaggt cgtgcgcgcc gtcgacccgc acggtccgtg cgcccgtcag
    21001 ccgggcgtcg ccccgtacca cccgcacgcc cgcgtgggcg aggtgcgcct ccaccccctt
    21061 gtggttccgg tccacgatgt cgtcgcgggt ggcgacgagg gccggccagt cgacgccgcc
    21121 caggctcgcc tcgacccccc agcgctcccg cgcctcggtg atgccgtcga ccagttcggc
    21181 ggcgtgcagc atcgccttgc tcgggatgca gccgcggtgc agacaggtcc cgcccacctt
    21241 gtcgcgttcg acgagggcgg tgtcgaggcc cagggccgcg gcacgcaggg cggtgctgta
    21301 accgccggtg ccgccgccga tgacgatcac gtcgtgtgtg ttcatgccct cagcctccgt
    21361 ccgcctcttg tcatgagtcc aaggcaatgt tcttgtggct tcgatgcagg aacttcatga
    21421 cgggtcccgg tgacgggcag ggcgcggggt gggggcgggg cggggatgag cctgcggcag
    21481 atggagtact tcctggcggt cctggacgag gcgtccttca cccgcgcggc cgaggccctg
    21541 cacgtcacgc agtccgcgct ctcccaccag atcaaggccc tggagcggtc ggtcggcggc
    21601 gccctgctgg agcgcatgcc gcgcggtgtg cgcctgaccc ccatgggccg cgccttccgg
    21661 ccgcacgccg aactcgccgt ccgcagcgcc gtccaggccc gccgagccgc ccgcgcggtc
    21721 gccggggccg agggcggcga actgcacgtc gccgccctgc actcggtggc cgtcggcatc
    21781 ctgcccgacg tcttcgcccg ctggcgcacc gcccaccccg gtgtcctgct gcacctccac
    21841 gagtacgcga cgaccgaggt gctcgaggag gaggtcgagc gcggcaccgc ggacctcgcc
    21901 gtcggcccgg cgcccagcga ctggtccggc accgtcgtca cggtcggcga ggaggagatc
    21961 gtcctcgtgg tgcccttcga cgaccggttc gcgggccgta cgacggtgac gctgcccgaa
    22021 ctggcggacc gtccctgggt ccggtgcgcc atggaacccc tcgtcgaggg cgaacgcttc
    22081 ctcgactggg cgtgcggacg cgccggcttc cggccgcgca ccgccgtcta caccgagcac
    22141 acgtcgacgg ccgtccggat ggccgccgcc ggcgtcggcg t
//
