LOCUS       NZ_CP012382            11410 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6235153
            Orig. end                         :: 6246563
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11410
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="17"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11410
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11410
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6410](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6410)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    94..110
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.43"
                     /tool="antismash"
     misc_feature    complement(95..110)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     gene            258..1736
                     /gene="hemG"
                     /locus_tag="SAM23877_RS27340"
                     /old_locus_tag="SAM23877_5755"
     CDS             258..1736
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325977.1"
                     /locus_tag="SAM23877_RS27340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5755"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_053138828.1"
                     /sec_met_domain="DAO (E-value: 2.2e-08, bitscore: 32.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCVSETSADVAAADPGHVVVVGAGIAGLAAAHRLLARGARVTVLE
                     ASERVGGKLLPGEIAGVRVDLGAESLLARRPEAVGLAREVGLADRLQPPSTASASLWTG
                     GALRPMPKGHVMGVPGTAAALSGVLSAEGLARIERDAELPRTEVGDDVAVGEYVAARLG
                     REVVDRLVEPLLGGVYAGDAYRISLRSAVPQLFEAARTHTSLTEAVRALQGRTATSPAT
                     GPVFMGIEGGVGSLPLAVAESVRARGGEIVTGAPVTELRRTAPSGWRITAGDRVLRADA
                     VVVAVPARPAAELLRAEAPAAAAELAAVEYASMALITLAYRRSDAAALPEGSGFLVPPV
                     EGRTIKASTFASRKWGWIADEDPDLVVLRTSVGRHGETEILGRDDAGLVAVSRRDLGEA
                     TGLTAEPVAARVTRWHDGLPQYPVGHHARVARVREHVGRVPGLAVCGAAYDGVGIPACI
                     ASAYAAVDRLRGDPRGVEELTAHPVQTLHGGAGE"
     gene            1741..2469
                     /gene="hemQ"
                     /locus_tag="SAM23877_RS27345"
                     /old_locus_tag="SAM23877_5756"
     CDS             1741..2469
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133767.1"
                     /locus_tag="SAM23877_RS27345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5756"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_053138831.1"
                     /transl_table=11
                     /translation="MSDDATPAAERIPNKGKLAKDLNEVIRYTLWSVFKLKDTLPEDRA
                     GWADEVQELFDQLAAKDVTVRGTYDVSGLRADADLMIWWHAETADELQEAYNLFRRTKL
                     GRALEPVWSNMALHRPAEFNRSHIPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRM
                     LADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARMHVRE
                     EVPFYTGRRKDIAELVAGLA"
     gene            complement(2470..4068)
                     /locus_tag="SAM23877_RS27350"
                     /old_locus_tag="SAM23877_5757"
     CDS             complement(2470..4068)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (109-484). E-value:
                     9.3e-20. Score: 63.2. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS27350_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972878.1"
                     /locus_tag="SAM23877_RS27350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5757"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_053138835.1"
                     /sec_met_domain="PF00561 (E-value: 4.9e-24, bitscore: 84.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAALYSAAGSLLLTALTAAPAEAGPAGPGAAEARGTAVAAERA
                     AAAGIEFGSCPKAEELPEAVRCGTVTVPLDYAHPGGEQLRLTVSRVRATHRDPHNSKRK
                     VPGQGALLYNPGGPGASGLYFPLVGMVPEWKRIAAAYDLVGYAPRGVAPSAPLSCQDPG
                     DFFKGPRAAPTRPSDAYKRERAAEAEAYARGCAERAGRALRHYHSLNNARDLEVVRAAL
                     GERRLTFMGASYGTYLGALYAELFPSRVRRMVFDSVVNPDPGQVWYRNNLDQSEAFEDR
                     WTDFKEWMAEHDAAYGLGDTAREVQNSYEEASTRLAARPAGGTVGPAQLQGAFLRAGYY
                     DDYWPHRAEALSAYLQGDPQPLVDQAGTRTEEGAVGAENSSAVYTAVECNDASWPTDFE
                     VWDRDNTRLARRAPFETWDNVWTNLPCAYWQAPRQRPLDVRTAPGELPPTLVLAAERDA
                     ATPYDGALELRRRLSGSVLVTERDAGTHGIAGGANACVNGHLEAYLLNGRLPARDESCA
                     PRPEPEPRESATPAS"
     aSDomain        complement(2617..3741)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS27350_Abhydrolase_1.1
                     "
                     /evalue="9.30E-20"
                     /label="SAM23877_RS27350_Abhydrolase_1.1"
                     /locus_tag="SAM23877_RS27350"
                     /protein_end="484"
                     /protein_start="109"
                     /score="63.2"
                     /tool="antismash"
                     /translation="ALLYNPGGPGASGLYFPLVGMVPEWKRIAAAYDLVGYAPRGVAPS
                     APLSCQDPGDFFKGPRAAPTRPSDAYKRERAAEAEAYARGCAERAGRALRHYHSLNNAR
                     DLEVVRAALGERRLTFMGASYGTYLGALYAELFPSRVRRMVFDSVVNPDPGQVWYRNNL
                     DQSEAFEDRWTDFKEWMAEHDAAYGLGDTAREVQNSYEEASTRLAARPAGGTVGPAQLQ
                     GAFLRAGYYDDYWPHRAEALSAYLQGDPQPLVDQAGTRTEEGAVGAENSSAVYTAVECN
                     DASWPTDFEVWDRDNTRLARRAPFETWDNVWTNLPCAYWQAPRQRPLDVRTAPGELPPT
                     LVLAAERDAATPYDGALELRRRLSGSVLVTERDAG"
     gene            complement(4185..4991)
                     /locus_tag="SAM23877_RS27355"
                     /old_locus_tag="SAM23877_5758"
     CDS             complement(4185..4991)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063321.1"
                     /locus_tag="SAM23877_RS27355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5758"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_053138838.1"
                     /transl_table=11
                     /translation="MFWVLLLLSAWSVAGLACLRLCLAAVRAAVVGPPTVGREHALTLY
                     EAAFLSGGPRRVADLTLVSMARQRRLLLAHTGWATVVDPCGRDEMERSVIGAIGPGGQS
                     RIAPVRATAATADAVRVLADRLVGAGLAVPDGSRGVAAGVRRVRTAALAVCALAAAALA
                     LPLPADQPRLLIALWFALPLALTLGCLAITRMEVHPYSRWASPAGQRLIGSLVQQADGT
                     ADDRTYLTSVAVRGVRAIGEPDLRAAFAHRERYVDEYAEGHGEPRG"
     misc_feature    complement(4955..4970)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.68"
                     /tool="antismash"
     gene            complement(5001..6410)
                     /locus_tag="SAM23877_RS27360"
                     /old_locus_tag="SAM23877_5759"
     CDS             complement(5001..6410)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327585.1"
                     /locus_tag="SAM23877_RS27360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5759"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_079030473.1"
                     /sec_met_domain="DUF692 (E-value: 5.4e-98, bitscore: 326.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARLGTGVGWRPEIADVVERMPGIDWVEAVAENLCPGHLPDSLLR
                     LRERGVTVVPHGVSLGLGDAGRPDAGRLAALAERAEALGSPLVTEHIAFVRAGGPMTAS
                     ERLEAGHLLPVPRTRDALDVLCENVRVAQDSLPVPLAVENIAALFSWPGEEMTEGQFLY
                     ELADRTGVRLLIDVANLHTNHVNRGEDPAEALSELPLEAIAYVHVAGGFERDGVWHDSH
                     AHAVPRPVLDILTDLASRVAPPGVLLERDENFPDAAELEAEVEAIRVAVGKGRAADGRP
                     GASATAPPRSARAEPRVTDAVRQRLALAQTALLSALVAGTPVPEGFDRVRLGVQARALA
                     AKRADVVAKVAPELPVILGAEYRPAFLAHAQRRPMTGGYRRDALDFVERLVRDGRPGDA
                     RVRHELRRWWEERSGPVPRSERPGVRWARAARRILPRRRTSSTSSNGTSHTHNTASRHV
                     NRAWRRRKPVA"
     misc_feature    6482..6496
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
     gene            complement(6531..7103)
                     /locus_tag="SAM23877_RS27365"
                     /old_locus_tag="SAM23877_5760"
     CDS             complement(6531..7103)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843393.1"
                     /locus_tag="SAM23877_RS27365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5760"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_053138842.1"
                     /transl_table=11
                     /translation="MAIDVRPASVFEDVRILLGPKSPGADVCWCLSYRVPSKVNNELRG
                     PARGAYVEELCRTGPPPGVLAHDGEEPVGWAAVAPRADTSFARSRTIPHVDDLPVWSLW
                     CVRVRPGHRGRGISHALIAGAVDFARSQGAPAVEAYPLDNGGARVDLTMAYAGIRSNFE
                     RAGFVHAADTTSVLAGHPRVLMRLDLR"
     gene            complement(7169..7888)
                     /locus_tag="SAM23877_RS27370"
                     /old_locus_tag="SAM23877_5761"
     CDS             complement(7169..7888)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006130509.1"
                     /locus_tag="SAM23877_RS27370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5761"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_053138845.1"
                     /transl_table=11
                     /translation="MSNEPTTSLPDSPFRPEPGDRDLAPQYVLPLVVRIERAAPPPRTD
                     ALETAARAVLVMLGDERSSGDGVWAGVMRDWQDARIRKVVRRARGAEWQRAEALPGITV
                     TGRAAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPRPPGDADLSAPVLWMNPGLDMSAG
                     KAMAQAGHGAQLAWWELDDAARAAWRDAGYPLAVRTPAPARWHALTTSGLPVVRDAGYT
                     EIAPGSCTVVADHPGLR"
     gene            complement(8013..8207)
                     /locus_tag="SAM23877_RS27375"
                     /old_locus_tag="SAM23877_5762"
     CDS             complement(8013..8207)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125244.1"
                     /locus_tag="SAM23877_RS27375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5762"
                     /product="hypothetical protein"
                     /protein_id="WP_053138847.1"
                     /transl_table=11
                     /translation="MSDDDRGSDDYCLIDAARPPRADGPPYAECVLCREPTEYAESYKG
                     ITMCPRCEWQEAQRTACSG"
     gene            complement(8226..9077)
                     /locus_tag="SAM23877_RS27380"
                     /old_locus_tag="SAM23877_5763"
     CDS             complement(8226..9077)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030618.1"
                     /locus_tag="SAM23877_RS27380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5763"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_053138850.1"
                     /transl_table=11
                     /translation="MITLVRRATALCLLGAALAACGTDQAPEAPRPAPSAPSAAPSKAA
                     PPPTLAPGPAGLTPVFEHGPRARGKTVALTFDADMTADQGPRAAAGERFDNPRLIEALR
                     ELKVPATVFMTGRWAEEYPDAARSLGRDPRFEIANHSYSHYAYTDDCYGLPSVSRERMR
                     ADVERAYTAFRKAGVANAMPYFRFPGGCYDRAALEELTATGVTAVQWDVVSGDAFATDA
                     DAVARQVLDGVRPGSVVVLHCTRSAAPVTERAVRTIVPELRSRGYRFVKVSELIGAGNG
                     RA"
     misc_feature    complement(9066..9081)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.09"
                     /tool="antismash"
     misc_feature    9108..9121
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.26"
                     /tool="antismash"
     gene            complement(9154..10677)
                     /locus_tag="SAM23877_RS41825"
                     /old_locus_tag="SAM23877_5764"
     CDS             complement(9154..10677)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972870.1"
                     /locus_tag="SAM23877_RS41825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5764"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_053138854.1"
                     /sec_met_domain="DAO (E-value: 6.6e-51, bitscore: 172.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKAQVNGSYWLETAPGGAPRPALAEDLDVDVAVIGAGVAGLSA
                     AWELTRAGRSVAVLEAGRVAAGVTGHTSAKLTALHSLVYDKLRRTRGPEGARLYARSQS
                     EAIAHAAGIVAELGIDCDWETRSAYTYVRDAGRVDELRAEAAAAREAGLPASFVTETGL
                     PFPVAGAVEVTGQAQFHPRKYLLALADDLEAHGGRIFEGTTVHGLDEGEPCRVRTEAGA
                     TVTARDVVVATHYPIFDRALLFARLSPRRELVVAGSVEADRDVDGMYITPDENTRSVRT
                     APLDDPGRRLLVVTGEHFTPGTGDTRERFDRLSAWAREHFPGVDLTHAWATQDIDPTDT
                     VPMVGPLHPGAHHTYVATGFGGWGLSGGMMAGRLLTAQITGEECAWSGLYDPRRLRTAV
                     REAPAFLKTQAEVARHFVGDRLKPAPPVDALPPGEGAVVRAGGDRLAVYRDEDGALHAL
                     SPRCTHLGCLVDFNAAERAWECPCHGSRFDTDGKVIEGPATKPLERRDI"
     misc_feature    complement(11172..11186)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.23"
                     /tool="antismash"
ORIGIN
        1 ccggtgagga cgagggccgc ggccaccaac aggccggccc aggcacgggc gggtggcgcg
       61 gaacgcgggg ctgatcgtcg ggtctgcatg cgggtacccc ccggggggac ggtgacaact
      121 gacgctcctt cgacgcgcga gggggtgcgg acgttggcgc ggaacggtcc cgaacaggtc
      181 acggtccgga ctcgcggggc cccgcggggc gtgggcctgg cggcgccgcc gtcggtgcgg
      241 tctgagacgc tgggggcatg tgcgtaagcg agacctccgc ggacgtggcc gccgcggacc
      301 cggggcatgt ggtcgtcgtc ggagccggca tcgccggact ggccgccgcc caccggctgc
      361 tggcccgcgg cgcgcgggtg accgtgctgg aggcgtcgga gcgcgtcggc ggcaagctgc
      421 tgcccggcga gatcgccgga gtacgcgtcg acctcggcgc cgagtccctg ctggcccgcc
      481 ggcccgaggc cgtgggcctc gcccgcgagg tgggcctcgc cgaccgcctc cagcccccgt
      541 ccaccgcgtc ggcctcgctg tggaccggcg gcgccctgcg ccccatgccc aaggggcacg
      601 tcatgggtgt ccccggcacc gctgccgcgc tgtccggagt cctctcggcg gagggcctcg
      661 cccggatcga gcgcgacgcg gagctgcccc gcaccgaggt cggcgacgac gtcgcggtgg
      721 gggagtacgt ggcggcgcgc ctcggccgcg aggtcgtcga ccgcctcgtc gaaccgctgc
      781 tcggcggtgt ctacgccggc gacgcgtacc gcatctcgct gcgctcggcc gtgccccagc
      841 tcttcgaggc cgcccgcacc cacacctccc tcaccgaggc ggtccgcgcc ctccagggcc
      901 ggacggccac ctcgcccgct accggaccgg tgttcatggg catcgagggc ggcgtcggct
      961 ccctcccgct cgcggtcgcc gagtcggtgc gcgcccgggg cggcgagatc gtcacgggag
     1021 cgcccgtgac ggagctgcgc cgtaccgccc cgagcggctg gcgcatcacc gccggtgacc
     1081 gggtgctgcg tgccgacgcc gtcgtcgtcg ccgtccccgc ccgccccgcc gccgagctcc
     1141 tgcgcgccga ggcccccgcc gccgcggccg aactggccgc cgtcgagtac gcctcgatgg
     1201 cactgatcac cctcgcctac cgccgctccg acgccgccgc gctccccgag ggcagcggtt
     1261 tcctcgtgcc gccggtcgag ggacgcacca tcaaggcgtc gaccttcgcc tcccgcaagt
     1321 ggggctggat cgccgacgag gacccggacc tggtcgtcct gcgcacctcc gtcggccgcc
     1381 acggcgagac ggagatcctc ggccgcgacg acgccggcct ggtcgccgtc tcccggcgcg
     1441 atctgggaga ggccacgggc ctgaccgccg agcccgtcgc cgcccgcgtc acccgctggc
     1501 acgacggcct gccccagtac ccggtcggcc accacgcccg cgtggcccgc gtccgcgagc
     1561 acgtcggcag ggtcccggga ctcgccgtgt gcggcgcggc ctacgacggc gtcggcatcc
     1621 cggcctgcat cgcgagcgcc tacgcggccg tggaccggct ccggggcgac ccgcggggtg
     1681 tggaggagct caccgcccac ccggtgcaga ccctgcacgg cggagcggga gaatagagcc
     1741 atgagtgacg acgccacccc cgccgccgag cgcatcccga acaagggcaa gctggccaag
     1801 gacctcaacg aggtcatccg ctacaccctc tggtccgtct tcaagctgaa ggacacgctg
     1861 ccggaggacc gggcgggctg ggccgacgag gtccaggagc tgttcgacca gctcgccgcc
     1921 aaggacgtca ccgtccgcgg cacctacgac gtgtccggtc tgcgggccga cgccgacctc
     1981 atgatctggt ggcacgcgga gaccgccgac gagctccagg aggcgtacaa cctcttccgc
     2041 cgcacgaagc tcggccgcgc cctggaaccc gtctggtcga acatggcgct gcaccgcccc
     2101 gccgagttca accgctcgca catcccggcg ttcctggccg acgagacgcc gcgcgactac
     2161 atcagcgtct acccgttcgt gcgctcctac gactggtacc tgctgcccga cgaggaccgc
     2221 cgccgcatgc tcgccgacca cggcaagatg gcccgcggct acccggacgt gcgcgccaac
     2281 acggtcgcct ccttctcgct gggcgactac gagtggatcc tcgccttcga ggccgacgag
     2341 ctctaccgca tcgtcgacct catgcgccac ctgcgcgcct ccgaggcccg catgcacgtc
     2401 cgcgaagagg tccccttcta caccgggcgc cgcaaggaca tcgcggagct ggtggccggg
     2461 ctcgcctgat caggaggccg gcgtcgcgga ctcccgcggc tccggctccg ggcgcggggc
     2521 gcacgactcg tcccgcgccg ggaggcggcc gttcagcagg tacgcctcca ggtgcccgtt
     2581 cacgcaggcg ttcgcgccgc cggcgatgcc gtgcgtaccg gcgtcccgtt cggtcaccag
     2641 caccgagccc gacagccgcc ggcgcagctc cagcgcgccg tcgtagggag tggccgcgtc
     2701 ccgctccgcg gccaggacca gcgtcggcgg cagctcgccc ggagcggtgc gcacgtcgag
     2761 gggccgctgc cggggtgcct gccagtaggc gcacggcagg ttggtccaca cgttgtccca
     2821 cgtctcgaac ggcgcccggc gcgccagccg cgtgttgtcc cggtcccaca cctcgaagtc
     2881 ggtgggccag gacgcgtcgt tgcactcgac ggccgtgtac acggcgctgg agttctccgc
     2941 ccccaccgcc ccctcctcgg tgcgcgtgcc cgcctggtcg accagcggct gcgggtcccc
     3001 ctggaggtac gccgacagcg cctcggcacg gtgcggccag tagtcgtcgt agtacccggc
     3061 ccgcaggaac gccccctgca gctgcgcggg ccccaccgtc ccgcccgccg gccgggccgc
     3121 gagccgtgtg ctcgcctcct cgtagctgtt ctgcacctcc ctcgccgtgt cgccgagccc
     3181 gtaggccgcg tcgtgctcgg ccatccactc cttgaagtcc gtccagcggt cctcgaacgc
     3241 ctcggactgg tccaggttgt tgcggtacca gacctgtccc gggtcggggt tcaccaccga
     3301 gtcgaacacc atccgccgca cgcgcgaggg gaacagctcg gcgtacagcg cgccgaggta
     3361 ggtgccgtac gacgcgccca tgaacgtgag ccgccgctcg cccagcgccg cccgcacgac
     3421 ctccaggtca cgggcgttgt tgagggagtg gtagtggcgc agcgcccgac cggcccgttc
     3481 cgcgcagccg cgggcgtacg cctcggcctc ggcggcacgc tccctcttgt acgcgtccga
     3541 cggccgcgtc ggggccgccc ggggcccctt gaagaagtca ccggggtcct ggcaggacag
     3601 cggcgcggag ggcgcgaccc cgcgcggggc gtagccgacg aggtcgtacg ccgccgcgat
     3661 ccgcttccac tcgggcacca tgccgaccag cgggaagtac agccccgagg cgcccggacc
     3721 gcccgggttg tacagcagcg cgccctgacc gggcaccttg cgcttgctgt tgtgcgggtc
     3781 ccggtgggtg gcccgcaccc ggctgacggt gagccggagc tgctccccgc cggggtgcgc
     3841 gtagtccagg ggcacggtga ccgtgccgca gcgcacggcc tccggcagct cctcggcctt
     3901 cgggcagctg ccgaactcga taccggccgc cgccgcgcgc tcggcggcca cggcggtgcc
     3961 gcgcgcctcg gcggcaccgg gcccggccgg gcccgcctcc gccggagcgg cggtcagggc
     4021 ggtcagcagc aaggacccgg cggccgagta gagggcggca gctcgcatcg cgtatccctt
     4081 ccatgcacac ggggtgacac aagggatggt tggcgcggcg accgggcggg gcaagcaccg
     4141 tcggcgggtg tcgcccccgc gtgcgcccgt acgcccccgg cgcgtcagcc ccgcggttcg
     4201 ccgtggccct cggcgtactc gtcgacgtac cgctcgcggt gggcgaaggc cgcgcgcagg
     4261 tccggttcgc cgatcgcccg gacgccccgc acggcgaccg aggtgaggta ggtacggtcg
     4321 tcggcggtgc cgtcggcctg ctgcaccagg ctgccgatca gccgctgccc ggccggtgag
     4381 gcccaccggg agtacggatg gacctccatg cgcgtgatgg cgaggcaccc cagggtcagg
     4441 gcgaggggca gcgcgaacca cagggcgatg agcagccgcg gctggtcggc ggggagcggc
     4501 agcgccaggg cggcggcggc cagcgcgcac acggcgagcg cggcggtccg tacccgccgc
     4561 accccggccg cgacaccgcg cgagccgtcc ggcacggcga ggcccgcgcc gaccagccgg
     4621 tcggccagga cccgtaccgc gtccgcggtg gcggcggtgg cccgcaccgg cgctatccgg
     4681 gactgcccgc cgggacctat cgcccctatg accgaccgct ccatctcgtc gcgcccgcac
     4741 gggtcgacga cggtcgccca gccggtgtgc gcgagcagca ggcggcgctg gcgcgccatg
     4801 gagaccaggg tcaggtcggc gacccgccga ggaccgccgg agaggaacgc cgcctcgtac
     4861 agcgtcagcg cgtgctcacg gccgacggtg ggcgggccga cgaccgccgc gcgcaccgcg
     4921 gccagacaca gccgcaggca cgccagcccg gcgacggacc aggcggacag gaggagaagc
     4981 acccagaaca tgccgtactt ctatgccaca ggctttcgcc ggcgccatgc cctgttcaca
     5041 tgtcgggacg cagtgttgtg ggtatgtgac gttccgtttg acgatgtcga gctggtccgg
     5101 cgacgcggca gaatccgccg ggccgcacgg gcccagcgga ccccgggccg ctccgaccgg
     5161 ggcaccggcc ccgaccgctc ctcccaccac cgacgcaact cgtggcgcac ccgcgcgtcc
     5221 ccgggacggc cgtcccgcac cagccgctcg acgaagtcga gggcgtcccg ccggtagccg
     5281 ccggtcatcg gccggcgctg ggcgtgggcg aggaaggccg gccggtactc cgcgccgagg
     5341 atcaccggca gctcgggcgc gaccttcgcg accacgtcgg cccgcttggc ggcgagcgcc
     5401 cgcgcctgga cgcccagccg tacccggtcg aacccctcgg ggacgggggt gccggcgacc
     5461 agcgcggaca gcagcgcggt ctgcgcgagg gcgagccgct gccgtacggc gtcggtgacg
     5521 cggggctcgg cgcgcgcgga gcgcggcggg gcggtcgcgc tcgcgccggg ccgcccgtcc
     5581 gccgcccggc ccttgcccac cgccacacgg atcgcctcga cctcggcctc cagctccgcc
     5641 gcgtcgggga agttctcgtc gcgttccagc aggacgccgg gcggtgcgac gcgcgaggcg
     5701 aggtcggtga ggatgtcgag caccggccgc ggaacggcgt gggcgtggct gtcgtgccag
     5761 acgccgtccc gttcgaagcc gcccgcgaca tggacgtagg cgatggcctc caggggcagt
     5821 tcggagaggg cctcggcggg gtcctcgccg cggttgacgt ggttggtgtg caggttcgcc
     5881 acgtcgatca gcagccgcac ccccgtccgg tcggccagct cgtacaggaa ctgcccctcc
     5941 gtcatctcct cgcccggcca ggagaagagc gcggcgatgt tctccacggc cagcggcacg
     6001 ggcagcgagt cctgcgcgac gcgcacgttc tcgcagagca cgtcgagggc gtcacgggta
     6061 cgcggcacgg ggagcaggtg cccggcctcc agccgctcgg aggcggtcat cggccccccg
     6121 gcccggacga acgcgatgtg ctcggtgacc agcggcgacc ccagcgcctc cgcccgctcc
     6181 gccaacgccg ccagacgtcc ggcgtccggc cgcccggcat ccccgaggcc gagcgagacg
     6241 ccgtgcggca cgacggtcac gccgcgctcg cgcagccgca gcagcgagtc gggcagatgc
     6301 ccgggacaga ggttctcggc cacggcctcg acccagtcga tgccgggcat ccgctcgacc
     6361 acgtccgcga tctccggacg ccatccgact ccggttccca gtcgtgccat tcgctccatg
     6421 gtccgtcccc ctcctgcgaa catgtggggg gtatcgccca ccccgcgcgg cccgaacccc
     6481 gggcaggtca tgttcagagc aacatctgag gttcgcggcg gcggcgccgg tcagcgcagg
     6541 tcgagccgca tcagcacccg ggggtggccg gccagcaccg acgtggtgtc ggcggcgtgg
     6601 acgaacccgg cgcgctcgaa gttgctccgg atgcccgcgt acgccatggt caggtcgacc
     6661 ctggcacccc cgttgtcgag ggggtacgcc tcgacggccg gagcaccctg ggagcgggcg
     6721 aagtcgaccg ccccggcgat gagggcgtgc gagatccccc gtccgcggtg accgggacgt
     6781 acgcggacgc accacagcga ccagaccggc aggtcgtcga cgtgcgggat cgtgcggctg
     6841 cgcgcgaagg aggtgtccgc gcgcggcgcc acggcggccc agccgaccgg ctcctcaccg
     6901 tcgtgggcga gtacgcccgg gggcggtccg gtacggcaca gctcctcgac gtacgcgccg
     6961 cgggccgggc cgcgcagctc gttgttcacc ttggagggga cgcggtagct caggcaccag
     7021 cagacgtcgg ccccgggcga cttggggccg agcaggatcc ggacgtcctc gaagaccgag
     7081 gccgggcgga cgtcgatggc catgggacca cgatgccacg gcgcccgggg cgacgcccgc
     7141 gatccgccgg cccacctcgc cgcgcccgct accgcaggcc cggatggtcc gccaccaccg
     7201 tgcacgatcc cggcgcgatc tccgtgtagc cggcgtcccg gaccaccggc agaccgctcg
     7261 tcgtgagggc gtgccagcgc gccggggcgg gggtgcgcac cgccagcggg tagccggcgt
     7321 cccgccaggc ggcccgggcc gcgtcgtcca gctcccacca ggccagctgg gcgccgtgcc
     7381 cggcctgcgc catcgccttg ccggccgaca tgtccaggcc cggattcatc cacaggaccg
     7441 gcgcggagag gtcggcgtcg ccgggcggcc gcgggtcgtc gaggtccgtg ccggagacct
     7501 ggaggcgggc caggtccttg ggccatccgt ccagcgggac cggcgggaag acccgcacct
     7561 cggccgcccg gccggtgacc gtgatgccgg gcagtgcctc ggcccgctgc cactcggcgc
     7621 cgcgcgcccg ccgcacgacc ttgcggatgc gcgcgtcctg ccagtcccgc atcacccccg
     7681 cccacacgcc gtcgccgctg gaccgctcgt cgccgagcat caccagcacc gcccgggccg
     7741 ccgtctccag cgcgtcggta cggggcggcg gtgccgcgcg ttcgatgcgg acgaccagcg
     7801 gcaggacgta ctgcggggcg aggtcgcggt cgccgggctc ggggcggaag ggggagtcgg
     7861 ggagggacgt cgtcggctcg ttgctcacgc ccaccagtct gccaagccgc tggggcgcga
     7921 gcggacgacc ccgtgcgacg cgagtggcgg ccggagcacg tgggccgccg ctacgacccg
     7981 cgcggtccct gggtaccgcg ccgcgtcgcg gatcagcctg aacaggccgt ccgctgggct
     8041 tcctgccact cgcagcgcgg gcacatggtg atccccttgt acgactcggc gtactccgtc
     8101 ggctcccggc acagcacgca ctccgcgtac ggcgggccgt cggccctggg cggccgggcc
     8161 gcgtcgatca ggcagtagtc gtcgctacct cggtcgtcgt cgctcatgct tccagcgtag
     8221 gcccgtcagg cgcggccgtt cccggcgccg atcagctccg agaccttcac gaagcggtag
     8281 cccctgctcc gcagttcggg gacgatcgtc cgtaccgccc gctcggtgac cggggcggcg
     8341 ctgcgggtgc agtgcaggac gacgaccgac ccgggccgca ccccgtccag cacctgccgg
     8401 gccaccgcgt cggcatccgt cgcgaaggcg tccccgctca ccacgtccca ctgcacggcg
     8461 gtgacgccgg tggcggtgag ctcctccagt gccgccctgt cgtagcaccc gccgggaaag
     8521 cggaagtacg gcatcgcgtt cgccacccct gccttcctga acgccgtgta cgcccgctcc
     8581 acgtcggccc gcatccgctc ccgggacacg gagggcaggc cgtagcagtc gtcggtgtag
     8641 gcgtagtggc tgtaggagtg gttcgcgatc tcgaaccgcg ggtcccggcc gagggaccgg
     8701 gccgcgtccg ggtactcctc ggcccaccgg ccggtcatga acacggtcgc cggcaccttc
     8761 agctcccgca gcgcctcgat cagccggggg ttgtcgaacc gctcgcccgc cgcggcccgg
     8821 ggcccctggt cggcggtcat gtcggcatcg aaggtgaggg cgacggtctt gcccctggct
     8881 cgcggaccgt gctcgaagac gggggtcagg cccgcggggc cgggcgcgag cgtcggaggc
     8941 ggggccgcct tcgagggggc ggcggagggt gcggacgggg ccgggcgggg agcctccggg
     9001 gcctggtcgg tcccgcaggc ggcgagggcg gcgcccagga gacagagagc ggtggcacgt
     9061 cgtacgagag tgatcaccgt acgaacgtat gagtgtgttg ttcggtatgt atgactatgc
     9121 gaggtgacgt gcccgggagg tcaccctccc gggtcagatg tcccgccgct ccagcggctt
     9181 cgtcgccgga ccctcgatca ccttgccgtc cgtgtcgaag cgggagccgt ggcaggggca
     9241 ctcccaggcg cgctcggccg cgttgaagtc gaccaggcag ccgaggtggg tgcagcgcgg
     9301 cgagagcgcg tgcagcgcgc cgtcctcgtc ccggtagacc gcgagccggt caccgccggc
     9361 ccggacgacg gcaccctcgc ccggcggcag ggcgtccacc ggcggggcgg gcttgagccg
     9421 gtcaccgacg aagtggcggg cgacctcggc ctgcgtcttg aggaacgccg gggcctcgcg
     9481 caccgccgtg cgcagccgcc gcgggtcgta caacccgctc cacgcgcact cctcaccggt
     9541 gatctgcgcg gtgagcagcc ggcccgccat catgccgccg ctcagccccc agccgccgaa
     9601 gcccgtggcg acgtacgtgt ggtgcgcgcc cgggtgcagc gggcccacca tcggcacggt
     9661 gtccgtcggg tcgatgtcct gcgtggccca ggcgtgggtg aggtcgacgc ccgggaagtg
     9721 ctcgcgggcc caggccgaca ggcggtcgaa gcgctcccgg gtgtcgcccg tgccgggcgt
     9781 gaagtgctcc ccggtgacga cgagcagccg gcggcccggg tcgtccaggg gcgccgtacg
     9841 gaccgagcgc gtgttctcgt cgggcgtgat gtacatgccg tcgacgtcgc ggtcggcctc
     9901 gacgctgccc gccaccacca gctcccggcg cggggagagc cgggcgaaca gcagggcccg
     9961 gtcgaagatc gggtagtgcg tggccaccac gacgtcccgg gcggtgaccg tcgcgcccgc
    10021 ctccgtccgc acgcggcacg gctcgccctc gtccaggccg tgcacggtgg tcccctcgaa
    10081 gatccgcccg ccgtgcgcct ccaggtcgtc ggcgagggcc agcaggtact tgcgcggatg
    10141 gaactgcgcc tgcccggtga cctcgaccgc gcccgccacc gggaacggca gccccgtctc
    10201 cgtcacgaac gacgcgggca gccccgcctc cctcgcggcg gcggcctcgg cgcgcagctc
    10261 gtccacgcgg cccgcgtcac ggacgtaggt gtacgcgctg cgggtctccc agtcgcagtc
    10321 gatgcccagc tcggccacga tgccggccgc gtgcgcgatc gcctccgact gggagcgggc
    10381 gtacaggcgg gcgccctcgg gaccgcgggt gcggcgcagc ttgtcgtaga cgagcgagtg
    10441 cagggcggtc agcttggcgc tggtgtggcc ggtgacgccg gcggccaccc gtccggcctc
    10501 cagcaccgcc acgctgcgcc cggcccgggt cagctcccag gccgcgctga gcccggcgac
    10561 gccggcgccg atcacggcga cgtcgacgtc gaggtcctcc gcgagggccg gccggggcgc
    10621 gccgccgggt gccgtctcaa gccagtacga gccgttgacc tgcgctttct ccgtcatgcg
    10681 gccccgggta ccccgttgtc acggcttcat tgaccgggcg gtgcgcccgg cgggtggacg
    10741 cgtccaccgg gcggacccgt ccaccgggcg gaacgcacgc tacctgcgcc agggtcccgt
    10801 caccgcgaag gtcgtgccgg gcgtgtagca gttgacgtac atcgtgtcgc cgtcggggga
    10861 gaaggtgacc ccggcgaact cgccccactc cggttcgtcc ggcgtcccga tgttctgggc
    10921 gccgcgggcc atcgcgtaga cctcgccgcg cctggtcacg ccgtagacgt gctgggcgcc
    10981 gttgccgtcc tcgcagacca tgaggccgcc gctgggggcc aggcagatgt tgtcggggga
    11041 ctcgccgggc agctggacgt cggtgtccgg gccgaagacg atcaccaggg tcaggcggcg
    11101 ccgctccggg tcgtagcgcc agatctggcc gtagtggtcg gccgccgagc cttccgcgct
    11161 gcgggcgaag gaggacacga agtacacgct gctcccgccc cagtagcagc cctccagctt
    11221 ctgcgcgtgg gtgacgccgc cccggccgaa gtcctggtgc cggatggggg tcccggtggc
    11281 cagcgggtcg ggtacgtcca cccactggac gccgtcgaac ccggcgcccg tctcctggat
    11341 cgacgacagg tcgggcaccc cgggcacgcg catcgcctgg agccgtccgc ccgcccgcag
    11401 cgagcccctg
//
