LOCUS       NZ_CP012382            21164 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5332696
            Orig. end                         :: 5353860
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21164
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="13"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21164
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21164
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11164](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11164
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(676..933)
                     /locus_tag="SAM23877_RS23845"
                     /old_locus_tag="SAM23877_5029"
     CDS             complement(676..933)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563321.1"
                     /locus_tag="SAM23877_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5029"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_003973730.1"
                     /transl_table=11
                     /translation="MDWRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQ
                     CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA"
     misc_feature    977..992
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    complement(978..989)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    1154..1163
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     misc_feature    1154..1168
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.74"
                     /tool="antismash"
     gene            complement(1253..2221)
                     /locus_tag="SAM23877_RS23850"
                     /old_locus_tag="SAM23877_5031"
     CDS             complement(1253..2221)
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134762.1"
                     /locus_tag="SAM23877_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5031"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_053136926.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD
                     LGRQAAQSDDIELVVALGGDGTVNEVVNGLLHAGPAPENLPRLAVVPGGSTNVFARALG
                     LPNHAVEATGALLDALREGSERTVGLGLASGTPGSEDESVPARWFTFNAGLGFDAGVVG
                     RVEQQRERGRRSTHALYLRQVMRALMGEPHRRSGTITLERAGEEPINDLVLSIVSNTCP
                     WTFLGNRPIYASPKASFDTGLDLFGLSRLSTGAVARYGTQLLTSSPERGPQGRHAVSLH
                     DLTGFTLHSKVPLPLQMDGDHLGLRTSVTFTGVRRALRVIV"
     gene            2350..2799
                     /locus_tag="SAM23877_RS23855"
                     /old_locus_tag="SAM23877_5032"
     CDS             2350..2799
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326947.1"
                     /locus_tag="SAM23877_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5032"
                     /product="hypothetical protein"
                     /protein_id="WP_053136929.1"
                     /transl_table=11
                     /translation="MSSEQNPTTPETAEERGPRPGRLTAAAALAALEGLALVVGGAWML
                     VGGLTGHPDDRTSALTGGVTLIVLALLPLLAARGLIARRGWSRGPAVITQIMALPVAYN
                     LLQADSVAIPAGIVLGVVAVTALVLLVNPTTTQALGIRGPGGAEK"
     gene            complement(2878..3939)
                     /locus_tag="SAM23877_RS23860"
                     /old_locus_tag="SAM23877_5033"
     CDS             complement(2878..3939)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136656.1"
                     /locus_tag="SAM23877_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5033"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_162492160.1"
                     /transl_table=11
                     /translation="MRDENGTRELPAEGARSENEARRVADGIDGIPEQARPHPEDETSP
                     GVVVPGDGPRTGDTPGRPVRAEARARERATGGTMSEHERHSEDGAPGARGPQGTRHDPQ
                     DRSGARLLFAELRTLEKDSPAYAELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVAT
                     IGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTATA
                     ELSQLHGRSPTVHELAERLSISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGA
                     EDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLAR
                     TLAQLREKLLVEE"
     gene            complement(3957..4370)
                     /locus_tag="SAM23877_RS23865"
                     /old_locus_tag="SAM23877_5034"
     CDS             complement(3957..4370)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985353.1"
                     /locus_tag="SAM23877_RS23865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5034"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_003973726.1"
                     /transl_table=11
                     /translation="MSQIAGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWTV
                     LSALAGKVSSAVDEDKTVSISLYKQRGAGPGPT"
     misc_feature    4498..4511
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.89"
                     /tool="antismash"
     misc_feature    4508..4523
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            complement(4620..4880)
                     /locus_tag="SAM23877_RS23870"
                     /old_locus_tag="SAM23877_5035"
     CDS             complement(4620..4880)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571357.1"
                     /locus_tag="SAM23877_RS23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5035"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_053136932.1"
                     /transl_table=11
                     /translation="MKQCTHADALPHPEPEPRSQTCPECLAEGTDPVQLRLCLYCGHVG
                     CCDSSPRQHATAHHNETGHPVMRTFEPGENWRWCFVDHVLV"
     gene            4942..6534
                     /locus_tag="SAM23877_RS23875"
                     /old_locus_tag="SAM23877_5036"
     CDS             4942..6534
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072182.1"
                     /locus_tag="SAM23877_RS23875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5036"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_053136935.1"
                     /transl_table=11
                     /translation="MDVMPLLLLVAGSAAIAAVGRRVPVPAPLLLVAAGLAVSYVPGVP
                     DYTLDPHIVLPLLLPPLLHTAATDSSYLDLRAQVRPVALLSVGYVLFATFVVGCAAYLI
                     VPGLPLTAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVA
                     LAAAVGEGATWAGGIGEFLIAAVGGVGVGLVLMAPIHWLRTHLKEALLQNTLSLLVPFF
                     AYAVAEQVHASGVLAVVVVALFLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGL
                     QLPVVLKGLGEYEGADAAWYAVAVFLVVAAARFVWVYPATFLPRLSARVRAREGDLSWK
                     GPFVISWAGMRGVVSLAIAFSIPLTVHGGEPFPGRNLILFLTFTTVIGTLVVQGVSLPP
                     LIRLLKFPARDVQAETLAEANAQAQASRAAEQRLDELLADERNALPAPLADRLRTVLER
                     RRNAVWERLGQANPVTGESVDDTYRRLSREMIGAEREVFVRLRDGRYIDDEMLRTLLRR
                     LDLEEAAAYRETA"
     gene            complement(6654..7562)
                     /locus_tag="SAM23877_RS23880"
                     /old_locus_tag="SAM23877_5037"
     CDS             complement(6654..7562)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973723.1"
                     /locus_tag="SAM23877_RS23880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5037"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_053142808.1"
                     /sec_met_domain="PALP (E-value: 1.1e-16, bitscore: 59.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTDPHDLTALRPRLPSPLQEVVDGRFERLGVRLLLKRDDLIHP
                     EVVGNKWRKLAPNLAMAADRTVVTFGGAYSNHLRATAAAGRLLGLSTVGVVRGQELAGR
                     PLNPSLERCAADGMRLHFVDRTTYRRTSDPETLGALLRAVDAEDAVVLPEGGSNAEAVR
                     GCRALGGELGEHADVAALACGTGGTLAGLAAGLPPGRRALGIPVLKGGFLTDEVRRLQI
                     RAFGGVRGAWSLDDRFHCGGYARTTPELDSFAEDFERRHGLPVERIYVAKMLHALLALT
                     QEGAFPRGTTLAAVITGRPFP"
     gene            complement(7600..8178)
                     /locus_tag="SAM23877_RS23885"
                     /old_locus_tag="SAM23877_5038"
     CDS             complement(7600..8178)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030135.1"
                     /locus_tag="SAM23877_RS23885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5038"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_053136937.1"
                     /transl_table=11
                     /translation="MSASSFIKALKAEGLTVVEVGDWRDHNRNHKGPWGPVHGVMIHHT
                     VTKGSARTVDICRKGYAGLPGPLCHGVITKDGRVHLVGYGRANHAGLGDDDVLRAVIAE
                     RGLPGDNEANTDGNRHFYGFECENLGDGDDPWPAAQLEAIERAAAAVCRHHGWNERSVI
                     GHLEWQPGKVDPRGFTMTSMRNRIGDRLR"
     misc_feature    8201..8214
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    8426..8439
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.08"
                     /tool="antismash"
     gene            8507..9913
                     /locus_tag="SAM23877_RS23890"
                     /old_locus_tag="SAM23877_5039"
     CDS             8507..9913
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136651.1"
                     /locus_tag="SAM23877_RS23890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5039"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_053136940.1"
                     /transl_table=11
                     /translation="MSVGEEVRTEQTRPQQSLGTAAARNLATTTKSVPQMQEISSRWLL
                     RTLPWVDIQGGTYRVNRRMTFAVGDGRVTFVKTGDRVEVIPAELGELPALRSYEDEEVL
                     SELARRCEQREFGPGEVIASFGGRADEVYLLAHGKVEKVGSGPYGDDAVLGVLADGAYF
                     GDEALLDGDAIWEYTARTVTACTVLVLPRQDVEQVAERSDSLRTHLEGRRSIPDQPTNR
                     HGEKAIDLSAGHSGEPDIPHTFVDYEARPREYELSVAQTVLRIHSRVADLYNQPMNQTE
                     QQIRLTVEALKERQEHELVNNREFGLLHNCEYDQRIQPHDGVPGPDDLDELLSRRRGTK
                     LLLAHPRAIAAIGRELNRRGLVPETIDIAGNRIPTWRGVPIYPCNKIPVTEARTTSIIA
                     MRTGEQDQGVIGLRATGIPDEIEPSLSVRFMGINEQAVIKYLVTAYYSAAVLVPDALGI
                     LENVEIGRWQ"
     misc_feature    9955..9971
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.43"
                     /tool="antismash"
     misc_feature    complement(9956..9971)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     gene            10001..11164
                     /locus_tag="SAM23877_RS23895"
                     /old_locus_tag="SAM23877_5040"
     CDS             10001..11164
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973720.1"
                     /locus_tag="SAM23877_RS23895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5040"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_053136942.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.9e-61, bitscore:
                     204.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEAPLGVTDPRRPTGTLERHGVIGTQRDKEPETPADGQGEEASA
                     EGHEAAALLRESRASVDPELRAAMATLPPSMRRTALYHFGWQHADGSPAAGNAGKAIRP
                     ALVLTSAAALGGPAARAAAVRAAAAVELAHNFTLLHDDVMDRDVTRRHRPTAWTVYGDA
                     DAILAGDALHALALRMLAADPHPASAAAAVRLADCVMELCEGQHTDTAMERRAPGEVTL
                     DETLAMAEAKTGALLGCACALGALYAGAPDEDVEALDRFGREAGLAFQLIDDVIGIWGD
                     PHRTGKPAGADLAARKKSLPVVAALTSGTPAAAELAELYAAPYEEDKEDLERTALAVER
                     AGGRDWAQAQAADHMARAMQELARAVPDPQAAGGLLALAEFVTRRST"
     gene            11448..12065
                     /locus_tag="SAM23877_RS23900"
                     /old_locus_tag="SAM23877_5041"
     CDS             11448..12065
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040424.1"
                     /locus_tag="SAM23877_RS23900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5041"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_053136945.1"
                     /transl_table=11
                     /translation="MGVVIRRAGEDDRERVVRLLDEAFQDDPVSSWVFPDVEHRRRTHH
                     RLMAAFTDAVLADGRIDLTEDGAACALWLPVPAGEHAGGGPEGDDGPAQVREAVDPENE
                     RVELIARLTEGVHPSDRAHEYLWMIGVVPRRQGEGLGTALIESVLDRCDREGLPAYLEA
                     SSARGRGLYERLGFEFTGRALDLPDGPRMWPMWREPRTPAQT"
     gene            complement(12477..12872)
                     /gene="sodN"
                     /locus_tag="SAM23877_RS23905"
                     /old_locus_tag="SAM23877_5042"
     CDS             complement(12477..12872)
                     /EC_number="1.15.1.1"
                     /GO_function="GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sodN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313646.1"
                     /locus_tag="SAM23877_RS23905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5042"
                     /product="superoxide dismutase, Ni"
                     /protein_id="WP_053136948.1"
                     /transl_table=11
                     /translation="MLSRLFAPKVTVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGN
                     DDPHFQTRATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKG
                     STDPATGQKALDYIAQIDKIFWETKKA"
     gene            13018..13452
                     /gene="sodX"
                     /locus_tag="SAM23877_RS23910"
                     /old_locus_tag="SAM23877_5043"
     CDS             13018..13452
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016485 - protein processing [Evidence
                     IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sodX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925778.1"
                     /locus_tag="SAM23877_RS23910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5043"
                     /product="nickel-type superoxide dismutase maturation
                     protease"
                     /protein_id="WP_053136951.1"
                     /transl_table=11
                     /translation="MPESSQEHERPRGALPFGPAEVTGPSMVPTLHHGDVLLVHWGSRV
                     RPGDVIVLRHPFQQDLLVVKRAVERRGAGWWVLGDNAFAGGDSTDYGVVPEELVLGRVR
                     LRYRPLRAGQRSPFAVARWALAALRPVLGDRSASRRLRAR"
     gene            complement(13356..13985)
                     /locus_tag="SAM23877_RS23915"
                     /old_locus_tag="SAM23877_5044"
     CDS             complement(13356..13985)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326935.1"
                     /locus_tag="SAM23877_RS23915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5044"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_053136954.1"
                     /transl_table=11
                     /translation="MELAYYSDYAVRLVNTEEPARGQDSLTSVEAVRELFGTNQSAARR
                     ATDTDVTRFRSVRGRLRAVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDHRDDDGS
                     PLWHMHLADHPSNATAGFAAIAAMGLAFHLTEYGVDRLGLCEAAPCRNAYLDTSTNRSR
                     RYCSDRCATRANVAAYRARKRLEADRSPSTGLSAASAQRATAKGER"
     misc_feature    complement(13951..13965)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.93"
                     /tool="antismash"
     misc_feature    13978..13993
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.99"
                     /tool="antismash"
     gene            14086..14865
                     /locus_tag="SAM23877_RS23920"
                     /old_locus_tag="SAM23877_5045"
     CDS             14086..14865
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030136.1"
                     /locus_tag="SAM23877_RS23920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5045"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_053136957.1"
                     /transl_table=11
                     /translation="MTDADITTATTPAADWQAWQKSWDRQQEWYMPDREDRFRIMLDMV
                     EALVGPAPRVLDLACGTGTITARLLDRFPEATSTGVDLDPALLAIAEGTFAGDDRVRLV
                     TADLKDPRWTAELPYDSYDAVLTATALHWLHAEPLAALYGRIAEVVRDGGVFMNADHMI
                     DETTPRINAAERAHRHAQMDAAKARGALDWAEWWRLAAEDPVLAGPTARRFEIYGEHAD
                     GDMPSAAWHARVLREKGFGEARPVWCSPSDTLLLALK"
     gene            complement(14935..15696)
                     /locus_tag="SAM23877_RS23925"
                     /old_locus_tag="SAM23877_5046"
     CDS             complement(14935..15696)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973712.1"
                     /locus_tag="SAM23877_RS23925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5046"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_053136960.1"
                     /transl_table=11
                     /translation="MTAMVKAEGVHKSFGAVEVLKGIDLEVEQGEVFCLIGPSGSGKST
                     FLRCINHLEKINSGRLYVDGELVGYRQKGDKLYELKDSEVAVKRRDIGMVFQRFNLFPH
                     MTAVENVMEAPVQVKGVSRSQARDRARQLLERVGLGDKAGNYPSQLSGGQQQRVAIARA
                     LAMDPKLMLFDEPTSALDPELVGDVLDVMRDLAESGMTMVVVTHEMGFAREVGDSLVFM
                     DDGVVVESGNPRDVLTDPQHERTKAFLSKVL"
     gene            complement(15693..16643)
                     /locus_tag="SAM23877_RS23930"
                     /old_locus_tag="SAM23877_5047"
     CDS             complement(15693..16643)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973711.1"
                     /locus_tag="SAM23877_RS23930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5047"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_053136963.1"
                     /transl_table=11
                     /translation="MTVDIDKTAGGPADTPPAGPEAIKAIPVRHYGRYISAVVAIALLA
                     AVVYAFSQGKINWGAIPDYFFDDRVLTGMGKTLLITVLAMLIGVVGGIMLAVMRLSKNP
                     VTSSIAWFYIWFFRGTPVLVQLVVWFNLGLVFEYINLGPFYRDEWSDFMTPFLTALLGL
                     GLNEAAYMAEICRAGLLAVDEGQTEAAHALGMSHTKTLRRIVVPQAMRVIVPPTGNEVI
                     NMLKTTSLVSVVQYAELFRVAQDIGQTSGAPAEMLFLAAAWYLLLTSVFSVGQYYLERY
                     YARGSSRSLPATPMQKIRANLLSLSNRSKTTGGAA"
     gene            complement(16674..17633)
                     /locus_tag="SAM23877_RS23935"
                     /old_locus_tag="SAM23877_5048"
     CDS             complement(16674..17633)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973710.1"
                     /locus_tag="SAM23877_RS23935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5048"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_053136967.1"
                     /transl_table=11
                     /translation="MTARSTRRTTAAQSRLAAVGAIAVAGALLLTGCGDQTEKSDSGSD
                     SQSAAGAPLADRLPQSIRDKGVVKVGSDIAYAPVEFKDKSGKTVGIDPDLADAMGKQLG
                     VKFEFENGTFDTLITGLRSKRYDIAMSAMTDTKDRQEGVDSDTGKKVGQGVDFVDYFTA
                     GVSIYTKKGDDQGIKTWSDLCGKKLVVQRGTVSEDLAKAENEKCPAGKKISMEAFDNDQ
                     QAQTRLRAGGAAAGSSDFPVAAYAVKTSGGGNDFQLVGEQVEAAPYGIAVAKDNAQLRD
                     ALKAALDAVIANGEYKKIMDKWGVAEGAVTEATINGGK"
     misc_feature    complement(17906..17921)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.47"
                     /tool="antismash"
     misc_feature    18024..18034
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(18231..18246)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            18275..19501
                     /locus_tag="SAM23877_RS23940"
                     /old_locus_tag="SAM23877_5049"
     CDS             18275..19501
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997977.1"
                     /locus_tag="SAM23877_RS23940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5049"
                     /product="NADP-dependent malic enzyme"
                     /protein_id="WP_053136970.1"
                     /transl_table=11
                     /translation="MAAEIVNPRSDSEAGTEQEAGEPLDSFDPAFALHRGGKMAVQATV
                     PIRDKDDLSLAYTPGVAKVCSAIAEQPDLVHDYTWKSSVVAVVTDGTAVLGLGDIGPEA
                     SLPVMEGKAILFKQFGGVDAVPIALDCTDADEIVETVVRLAPSFGGVNLEDISAPRCFE
                     IERKLQERLDIPIFHDDQHGTAVVTLAALRNAARLSGRTLGELRAVISGAGAAGVAIAK
                     MLVEAGIGDVAVADRKGVVSADRDDLTPVKRELASFTNKAGLSGTLEAALSGADVFIGV
                     SGGTVPEPAVASMAEGAFVFAMANPNPEVHPEVAHKYAAVVATGRSDFPNQINNVLAFP
                     GIFAGALQVRASRITEGMKLAAAEALASVVGDDLAADYVIPSPFDERVAPAVTAAVAAA
                     ARAEGVARR"
     gene            19683..20648
                     /locus_tag="SAM23877_RS23945"
                     /old_locus_tag="SAM23877_5050"
     CDS             19683..20648
                     /NRPS_PKS="Domain: PKS_ER (17-318). E-value: 1.3e-33.
                     Score: 108.5. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS23945_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973708.1"
                     /locus_tag="SAM23877_RS23945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5050"
                     /product="quinone oxidoreductase"
                     /protein_id="WP_053142810.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-19, bitscore:
                     69.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAVYAARIDRDQPLTGLELGERPAPEARPGWSVVDVRAASLNHH
                     DLWSLRGVGLPEDRLPMILGCDAAGVDEDGNEVVLHSVIGQTGHGVGPEEPRSILTERY
                     PGTFAERVAVPTWNILPKPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAG
                     GGVATAAIVLGKAAGLRVFATSRDEAKRKRAVELGAVEAVEPGARLPQRVDAVIETVGA
                     ATWSHSVKSLRPGGTLVISGATSGDRPSHAELTRVFFLELRIVGSTMGTKDELEDLLSF
                     CAATGVRPVIDEVLPLDRAREGFERMASGEQFGKIVLSGS"
     aSDomain        19734..20636
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS23945_PKS_ER.1"
                     /evalue="1.30E-33"
                     /label="SAM23877_RS23945_PKS_ER.1"
                     /locus_tag="SAM23877_RS23945"
                     /protein_end="318"
                     /protein_start="17"
                     /score="108.5"
                     /tool="antismash"
                     /translation="LELGERPAPEARPGWSVVDVRAASLNHHDLWSLRGVGLPEDRLPM
                     ILGCDAAGVDEDGNEVVLHSVIGQTGHGVGPEEPRSILTERYPGTFAERVAVPTWNILP
                     KPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGKAAGLR
                     VFATSRDEAKRKRAVELGAVEAVEPGARLPQRVDAVIETVGAATWSHSVKSLRPGGTLV
                     ISGATSGDRPSHAELTRVFFLELRIVGSTMGTKDELEDLLSFCAATGVRPVIDEVLPLD
                     RAREGFERMASGEQFGKIVL"
     CDS_motif       20073..20111
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAM23877_RS23945_0001"
                     /evalue="5.60E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="SAM23877_RS23945"
                     /protein_end="143"
                     /protein_start="130"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AACLPTAWLTAYR"
     CDS_motif       20142..20195
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAM23877_RS23945_0002"
                     /evalue="6.00E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="SAM23877_RS23945"
                     /protein_end="171"
                     /protein_start="153"
                     /score="15.7"
                     /tool="antismash"
                     /translation="GDSVLVQGAGGGVATAAI"
     gene            20792..21001
                     /locus_tag="SAM23877_RS23950"
                     /old_locus_tag="SAM23877_5051"
     CDS             20792..21001
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384656.1"
                     /locus_tag="SAM23877_RS23950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5051"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_053142812.1"
                     /transl_table=11
                     /translation="MSEATDLAARAGDRDPRVGLRAVAALRRLLEQLEAVQVRAARHQG
                     WSWQEIASELGVSRQAVHKKYGRH"
ORIGIN
        1 atcgccgacc gcgtactggc gatggtggcg gagatctcgc cgggcaaggt caccggccgg
       61 cgcaccggac gcttcggcat cctggacgcc gaggtggcga ccccgctgtc gatggtcctg
      121 accgaggtgc tgcagaacgc cctggagcac ggcttccgcg agggcgacac cggcacggtc
      181 gaggtctccg cggtccgtgg cggcacgacg aaggaggccc ggctgctggt caccgtccag
      241 gacgacgggg tcggcctgcc cgaggacttc gacccgcacc gctccggcaa cctcggcctg
      301 cagatcgtgc gcaccctggt ggagggtgag ctgggcggct ccttcgacat ggtcccggcc
      361 ccgagccgcg gcacccgggt gatcctcgac atcccggtgc ccgcggcgaa gtagcggggc
      421 cgggggagag ggcgaaggga aggggccgca ggaggcaggg ccggcccgcc gggcgcgggc
      481 tcggcgcggg tgcccgggac gcgggagccg ggggcggaca gcaaaaagcc ccggaccggt
      541 gaaggtccga ggccagtgct cgtgcgttgc atcgttcgat gcgcatcggg ggtactgcgc
      601 gctgcggctc gggagcgggg gttgcgtact cgctgtacgc gccgccaagc tcaggctgtc
      661 agcaggggtg gatggtcagg cggaggcctg acgagcccgg ttgcgggcgg cacggcgctt
      721 cattgcgcgg cgctcgtcct cgctgagacc accccagacg ccggagtcct ggccggactc
      781 gagcgcccac tgcaggcact gctccatgac agggcagcga cggcagacgg ccttggcttc
      841 ctcgatctgc agcagcgcgg gaccggtgtt gccgatgggg aagaagagct cggggtcttc
      901 ctcgcggcaa acggcgcggt gacgccagtc catggctgct acctctcctt ggtattacat
      961 gcaggttgct tgtgaatgtg aacgctttca cgaatccctc aacaagggaa gggcctaccg
     1021 ccaggttgcc cggcgtggtc ctgtgatttg aagaggggtt ctggtgatct gtggaggctg
     1081 gtgttgcggg ccgtcccgat cgccaagaag agactcgcaa acctcagcgg cggatacaac
     1141 cccttccgga aagttttttt tgattcttcg gtgtcgacta ggtcacagcc gtacttccat
     1201 ggggtggacc ctggtctaaa cgttcgagtg aaaggacttt cgccccttct gctcacacaa
     1261 tcacacgcag tgcacggcgt acgcctgtga acgtcacgct ggtccgcagt cccaggtggt
     1321 caccgtccat ctggaggggg agcgggacct tcgaatgcaa ggtgaacccg gtcagatcgt
     1381 gcagggagac ggcgtgccgg ccctggggtc cgcgctcggg ggacgaagtg agcaactggg
     1441 tgccataccg ggcaaccgca cccgtggaca ggcggctgag accgaagagg tcgagcccgg
     1501 tatcgaacga ggccttaggt gacgcgtaga tcgggcgatt gccgagaaac gtccaggggc
     1561 acgtgttcga gactatggag agcacgagat cgttgatcgg ctcctcgccc gcccgctcca
     1621 gggtgatcgt cccgctgcgg cggtgcggct ctcccatgag cgcccgcatg acctggcgga
     1681 ggtagagggc gtgggtggat ctcctgccgc gctcgcgctg ctgctccaca cggccgacca
     1741 cgccggcgtc gaagcccagc cctgcgttga aggtgaacca gcgggccggc accgactcgt
     1801 cctccgagcc cggcgtgccc gaggcgaggc ccagtccgac ggtccgctcg ctgccctcgc
     1861 gcagggcgtc cagcagggcg ccggtggcct ccaccgcgtg gttgggcagg ccgagggcgc
     1921 gggcgaagac gttggtggag ccgccgggga ccaccgcgag gcggggcagg ttctccgggg
     1981 cggggccggc gtgcagcaga ccgttgacga cctcgttcac cgtgccgtcg ccgccgaggg
     2041 cgaccaccag ctcgatgtcg tcgctctgcg ccgcctgccg gccgaggtcg cgcgcgtggc
     2101 cgcggtactc ggtggtgacc gcctccagct tcatctcgct cgcgagcgcg tggatgagca
     2161 cgtcgcgcgt gcgcgcgctc gtggtggttg ccgccggatt gaccacgaga agtgcacgca
     2221 tggtttgcag ggtacctact gggtggtacc cggcccagac cgagggggag atcgggacgg
     2281 gcgcacgggc gtggacggtg cgccggacgc gcccgccggt tcccgtgcgc cgggggctac
     2341 cctgcaaggg tgagcagtga gcagaacccc accacccccg aaaccgccga agagcgcggt
     2401 ccccgtcccg gccggctgac cgccgcggcg gcgctcgccg cactggaggg gctggcgctc
     2461 gtcgtgggcg gcgcctggat gctggtgggc ggtctcacgg gccatcccga cgaccggacc
     2521 tcggccctca ccggcggcgt caccctgatc gtcctcgccc tgctgccgct gctcgccgcc
     2581 cgcggcctga tcgcccggcg gggctggagc cggggtcccg ccgtcatcac gcagatcatg
     2641 gcgctgcccg tggcctacaa cctgctccag gccgacagcg tggccatccc ggcgggcatc
     2701 gtgctcggtg tcgtcgccgt cacggcgctg gtgctgctcg tgaaccccac gaccacccag
     2761 gccctcggga tccgggggcc cggcggcgcg gagaagtagg ccgtcccgcc cggcgggtgt
     2821 ccgggcgcat ccggcgcccg gtcatgtccg ggtccggtgg tccgcgggcg cggtcgacta
     2881 ctcctcgacc agcagcttct cccgcagctg cgccagtgtg cgggccagca gccgcgacac
     2941 gtgcatctgc gagataccga cctcctgcgc gatctgcgac tgggtcatgt tgccgaagaa
     3001 acgcagcagc aggatccgct tctcccgcgg cggcaggtcc tccagcagcg gcttgagcga
     3061 ctcccggtac tcgacgccct ccagggcctc gtcctccgct cccagggtgt ccgcgaccgc
     3121 cggggactcg tcgtcggtgt ccgggacgtc cagggacagc gtggagtacg cgttggccga
     3181 ctccaggcct tccaggacct cctcctccga gatcgacagc ctctcggcga gctcgtggac
     3241 cgtgggggag cgcccatgca gctgcgagag ctccgccgtg gccgtggtca gggccagccg
     3301 cagctcctga agccggcgcg ggacccgcac cgcccagccc ttgtcccgga agtgccgctt
     3361 gatctcgccg acgaccgtcg gggtcgcgta cgtggagaac tccacgccgc ggtccgggtc
     3421 gaagcggtcg accgacttga tcagcccgat ggtcgcgacc tgggtgaggt cgtccagcgg
     3481 ctcgccgcgg ttgcggaagc ggcgcgcgag gtgctccacg agcggcaggt gcatgcggac
     3541 cagccggttg cgcagctccg cgtaggcggg gctgtccttt tccagggtgc gcagctcggc
     3601 gaacaggagg cgcgccccgc tgcggtcctg cgggtcgtgc cgcgtgccct gcgggccccg
     3661 tgcgcccggc gcgccgtcct cggagtgtcg ctcgtgctcg ctcatcgtcc cgcccgttgc
     3721 cctttcccga gccctcgcct ccgctcggac gggccggccg ggggtgtccc cggtccgtgg
     3781 cccgtcaccc gggacgacga ccccggggga ggtctcgtcc tccggatgcg gccgggcctg
     3841 ctcggggatg ccgtcgatgc cgtccgccac gcgtcgggcc tcgttctcag aacgtgcgcc
     3901 ctcggccggc agctcccgtg tgccgttctc gtcccgcacc ggcccgtccc cgtccctcac
     3961 gtcggcccgg gtcccgcgcc gcgctgtttg tagaggctga tcgaaacggt tttgtcctcg
     4021 tccacggcgg aggagacctt gcccgccagg gcggacagca cggtccacgc gaaggtgtcg
     4081 cgcgagggcg cgtggccgtc cgtggtcggc gccgagacgg tgacctcgag cgagtcgtcg
     4141 acgaggcgga agacacagct gagcaccgag ccgggcacgg cctgctgaag caggatcgcg
     4201 caggcctcgt cgactgcgat gcgcaggtcc tcgatctcgt cgagggtgaa gtccaaacgg
     4261 gctgcgaggc cggccgtcgc cgtacgcagc accgacaggt aggcacccgc ggccggcagc
     4321 cggacttcga cgaagtcctg ggtcgcgggc tcgcctgcga tctgggacac cctcacctcc
     4381 aaggtggtac aagcgttaca gggccgagga tcgaccccgg ggcaacgcga tacgtggttc
     4441 agcggtgacg ttatcgcgct ccgaactttc ctgtccccga gaccccaacc ccgcactgtc
     4501 actcatagta aacacatgaa cacgcacagt ggctagaggt tcggcgggcc caaatcggaa
     4561 gagcgcgcgc cgggttgacg tacccaggcc tcagacggtc gaaccgtctc cggccgaggt
     4621 cacacgagga cgtggtcgac gaagcaccaa cgccagttct cgcccggttc gaaggtgcgc
     4681 atcaccgggt gaccggtctc gttgtgatgt gccgtggcgt gctgcctcgg cgaggagtcg
     4741 cagcagccga cgtgcccgca gtagaggcac agccggagct gtaccgggtc cgtgccctcc
     4801 gccaggcact ccggacaggt ctggctgcgc ggctccggtt ccgggtgcgg cagcgcgtcg
     4861 gcgtgcgtgc actgtttcat gattgccagg ttacgacggg cgtgcggatg gccgcgcgga
     4921 aaaagagggc gggcgaggac gatggacgtg atgccgctgc tgttgctggt cgcgggcagt
     4981 gccgcgatcg cggcggtggg gcggcgggtg ccggtgcccg cgccactgct gctggtcgcg
     5041 gcgggcctgg cggtgagcta cgtccccgga gtgcccgact acaccctcga cccgcacatc
     5101 gtcctgcccc tgctgctgcc cccgctgctc cacacggcgg ccaccgacag ctcctacctg
     5161 gacctgcggg cgcaggtgcg gcccgtggcg ctgctctccg tgggctacgt gctcttcgcg
     5221 accttcgtcg tcggctgcgc cgcgtacctg atcgtgccgg gcctgccgct gaccgcggcc
     5281 ctggtcctcg gcgcggtggt ggcgccgccg gacgccgtcg cggccacggc ggtcgcccgc
     5341 cgggtgggtc tgccgtcccg gatcacgacg atcctccagg gcgagtccct ggtgaacgac
     5401 gccaccgcga tcaccgcctt caaggtggcg ctggcggcgg ccgtgggcga gggggcgacc
     5461 tgggccggcg ggatcgggga gttcctgatc gcggcggtgg gcggcgtggg cgtgggcctg
     5521 gtgctgatgg cgccgatcca ctggctgcgc acgcatctga aggaggcgct cctgcagaac
     5581 acgctctccc tgctcgtccc gttcttcgcc tacgcggtgg cggagcaggt gcacgcgtcc
     5641 ggggtgctcg cggtggtggt cgtcgcgctc ttcctcgggc accgcgcgtg ggaggtcgat
     5701 ttcgccaccc gtctccagga ggaggcggtg tggaagatgg tggccttcgt gctggagtcg
     5761 gccgtgttcg ccctgatcgg actccagctt cccgtcgtcc tcaagggact cggggagtac
     5821 gagggtgccg acgccgcctg gtacgcggtc gccgtcttcc tggtggtcgc cgccgcccgc
     5881 ttcgtctggg tctacccggc gaccttcctg ccgaggctgt cggcacgcgt ccgcgcgcgc
     5941 gagggggacc tgtcgtggaa ggggccgttc gtgatcagct gggcggggat gcgcggggtc
     6001 gtctccctgg cgatcgcctt ctccatcccg ctcaccgtgc acggcggcga gcccttcccc
     6061 ggacgcaacc tcatcctgtt cctcaccttc accacggtca tcggcacgct ggtcgtgcag
     6121 ggcgtgagcc tgccgccgct gatccgcctg ctgaagttcc ccgcgcgcga cgtacaggcc
     6181 gagacgctgg ccgaggcgaa cgcccaggcg caggcctccc gcgccgccga gcagcgcctg
     6241 gacgagcttc tcgcggacga gcgcaacgcc ctgcccgccc cgctcgcgga ccgtctccgt
     6301 acggtcctgg aacgccgccg caacgccgtc tgggaacggc tcggacaggc caaccccgtc
     6361 accggggaga gcgtggacga cacctaccgg cggctgtccc gggagatgat cggtgccgag
     6421 cgcgaggtct tcgtccggct gcgcgacggc cgctacatcg acgacgagat gctccggacg
     6481 ctgctgcgcc ggctggacct ggaggaggcg gcggcgtacc gggagacggc atagacggac
     6541 cggcccggca gggagcggcc cggcatggac cgtcggccgg gagtgggccc ggaccgtctc
     6601 ggccgggaga gggcgcgggc ggtggccgcc gccggttcgt cgcgccgccc ggctcagggg
     6661 aaggggcggc cggtgatgac cgccgccagg gtcgtcccgc gggggaaggc gccctcctgg
     6721 gtgagggcga gcagggcgtg cagcatcttg gcgacgtaga tgcgctccac gggcaggccg
     6781 tggcggcgtt cgaagtcctc ggcgaaggag tcgagctcgg gggtggtgcg ggcgtagccg
     6841 ccgcagtgga agcggtcgtc gaggctccag gcgccccgga ccccgccgaa ggcccggatc
     6901 tggaggcgcc gtacctcgtc ggtcaggaag ccgcccttga ggacgggtat gccgagcgcc
     6961 cgtctccccg gggggaggcc ggcggccagc cccgcgagcg tgccgccggt gccgcaggcg
     7021 agcgcggcca cgtcggcgtg ctcgcccagt tccccgccga gggcccggca gccgcggacg
     7081 gcctccgcgt tgctgccgcc ctcggggagg acgaccgcgt cctcggcgtc caccgcgcgc
     7141 aggagggcgc ccagggtctc cggatcggat gtgcggcggt acgtcgtgcg gtcgacgaag
     7201 tgcagtcgca tgccgtcggc cgcgcaccgc tccagcgacg ggttgagcgg ccggccggcc
     7261 agctcctggc cgcgcaccac gcccaccgtg gacagcccga gcaggcggcc ggcggcggcc
     7321 gtcgcgcgca ggtggttcga gtaggcgccg ccgaacgtga cgaccgtgcg atccgcagcc
     7381 atggcgagat tcggtgccag tttgcgccat ttgttgccga ccacctcggg gtggatcagg
     7441 tcgtcccgct tgaggagcag ccggacaccg agacgctcga accgcccgtc gacgacctcc
     7501 tgcaaggggg agggcaggcg gggccgcagg gcggtgaggt cgtgggggtc ggtgccggtc
     7561 accccgtcat tgtcgcgccg ccgcgcgacg gcgggcacgt cacctcagcc ggtcgccgat
     7621 ccggttccgc atcgaggtca tcgtgaaccc ccgcgggtcc accttgcccg gctgccattc
     7681 gaggtggccg atgacggacc gctcgttcca cccgtggtga cggcagaccg cggcggcggc
     7741 ccgttcgatc gcctccagct gcgccgcggg ccaggggtcg tcgccgtcgc ccaggttctc
     7801 gcactcgaac ccgtagaagt gccggttgcc gtcggtgttc gcctcgttgt cccccggcag
     7861 ccccctctcc gcgatcaccg cgcgcaggac gtcgtcgtcg cccagccccg cgtggttggc
     7921 cctgccgtac ccgaccaggt ggactctgcc gtccttggtg atcaccccgt ggcacagcgg
     7981 ccccggcagg cccgcgtagc ccttgcggca gatgtccacc gtccgtgcgc tgcccttggt
     8041 gaccgtgtgg tggatcatca cgccgtgcac gggcccccag gggcccttgt ggttgcggtt
     8101 gtggtcccgc cagtcgccga cctcgacgac ggtgagtccc tccgccttga gcgccttgat
     8161 gaaactgctc gcggacatgg gtgaggccac gctcggctcc ttcactctgc gcgacgaccg
     8221 cccggcgcgt tcgcctccta cggtgcttgt accgaaacgg agcgctccct agtacttggt
     8281 cggtccgcga gcgagcggtt tcggacaatc tcatcccggc caactgccct gaacggggcc
     8341 ggacaagacg ccgagacgcc gaacaagcac ccatacctgc ccgggtctcc ggtgatccat
     8401 tcccgctctt tcgggtaata ccatcagcac gctccgtgag gaaggctggt cctcgcacat
     8461 cgatgccggg cgcagccgtc cggcatgacc gggagggcaa ttccttatgt cggtaggcga
     8521 agaggtccgc accgagcaga ccaggccgca gcagagcctc ggcacggcgg ccgcgcggaa
     8581 cctggccacc acgaccaagt ccgttcctca gatgcaggag atcagctcgc gctggctgct
     8641 gcgcaccctc ccctgggtgg acatccaggg cggtacgtac cgggtgaacc ggcgcatgac
     8701 cttcgccgtg ggggacggca gggtgacgtt cgtgaagacc ggcgaccgcg tcgaggtcat
     8761 cccggcggag ctgggcgagt tgccggccct gcgctcgtac gaggacgaag aggtcctctc
     8821 ggagctcgcg cgccgctgcg agcagaggga gttcggccct ggtgaggtga tcgcctcctt
     8881 cggcggccgg gccgacgagg tctacctgct ggcgcacggc aaggtggaga aggtcggcag
     8941 cggcccctac ggtgacgacg cggtgctcgg cgtcctcgcc gacggcgcct acttcggcga
     9001 cgaggcgctg ctcgacgggg acgccatctg ggagtacacc gcccggacgg tcaccgcctg
     9061 cacggtgctc gtcctgccgc gccaggacgt ggagcaggtc gcggagcgtt cggactcgct
     9121 gcgcacgcac ctggaggggc ggcgctcgat ccccgaccag cccaccaaca ggcacggcga
     9181 gaaggcgatc gacctctccg ccgggcacag cggcgagccc gacatcccgc acaccttcgt
     9241 cgactacgag gcccggcccc gtgagtacga gctgagtgtc gcccagaccg tgctgcgcat
     9301 ccactcgcgc gtggccgacc tctacaacca gccgatgaac cagacggagc agcagatccg
     9361 tctgaccgtc gaggcactga aggagcgcca ggagcacgag ctcgtcaaca accgcgagtt
     9421 cggcctcctg cacaactgcg agtacgacca gcgcatccag ccgcacgacg gggttcccgg
     9481 cccggacgac ctggacgagc tgctgagccg ccggcgcggc accaagctgc tgctcgccca
     9541 cccgcgcgcg atcgccgcga tcggccgcga gctcaacagg cgcgggctcg tccccgagac
     9601 gatcgacatc gcgggcaacc gcatcccgac ctggcgcggc gtgccgatct acccgtgcaa
     9661 caagatcccg gtcaccgaag cccgtacgac gtcgatcatc gcgatgcgta ccggcgagca
     9721 ggaccagggc gtcatcggtc tgcgggccac cggcatcccg gacgagatcg agccgagtct
     9781 gtcggtgcgc ttcatgggca tcaacgaaca ggccgtcatc aagtacctgg tcacggccta
     9841 ctactcggcc gcggtcctcg tgccggacgc gctcggaatc ctggagaacg tcgagatcgg
     9901 ccgctggcag tgacgccagt cttccgaacg ccgtgtcccc gccctcgcgg gcgggtacac
     9961 cccgggggta cggaggcgga cgtatggggg aggtgagtcc atgacggagg ctccgctcgg
    10021 cgtcaccgac ccgcgtcgtc ccaccggcac gctggaaagg cacggggtca tcggcacgca
    10081 gcgggacaag gagccggaga cgcccgccga cgggcagggg gaggaggcct cggccgaggg
    10141 gcacgaggcg gcggcgctcc tgcgggagtc acgggcgtcg gtcgaccccg aactgcgggc
    10201 cgccatggcg acgttgcccc cctcgatgcg ccgcaccgcg ctctaccact tcgggtggca
    10261 gcacgcggac ggcagccccg cggccggtaa cgcgggcaag gcgatccggc ccgcactcgt
    10321 cctcacctcg gccgccgccc tcggcggacc cgcggcccgg gcggcggcgg tgcgggccgc
    10381 ggccgcggtg gaactggccc acaacttcac cctgctccac gacgacgtga tggaccggga
    10441 cgtcacccgc cgtcaccggc cgaccgcgtg gaccgtctac ggcgacgccg acgcgatcct
    10501 cgcgggggac gccctccacg cactggccct gcggatgctc gcggcggacc cgcacccggc
    10561 gtccgccgcg gcggccgtcc ggctcgccga ctgcgtcatg gagttgtgcg agggccagca
    10621 cacggacacg gccatggaac ggcgcgcccc gggcgaggtc accctggacg agacgctcgc
    10681 catggccgag gccaagacgg gcgccctgct gggctgcgcc tgcgccttgg gcgcgctgta
    10741 cgccggcgct ccggacgagg acgtcgaagc cctggaccgc ttcggccgcg aggccgggct
    10801 ggccttccag ctcatcgacg acgtgatcgg catatggggc gatccgcacc gcaccggcaa
    10861 gccggccggg gcggatctcg ccgcccgcaa gaagtcgctg cccgtcgtcg ccgcgctcac
    10921 ctcgggcacc ccggcggccg ccgagctcgc cgagctctac gcggcaccgt acgaggagga
    10981 caaggaggat ctggagcgca ccgcactggc cgtggagcgg gcgggcggcc gggactgggc
    11041 tcaggcccag gcggccgacc acatggccag ggccatgcag gaactggccc gagccgtgcc
    11101 cgacccgcag gcggcgggcg gactgctcgc gctggccgag ttcgtgaccc ggcgcagcac
    11161 ctgaccgtcg cgccgggccg cttcgatcgc cccgggcggg tcatcgagca gcccggcgac
    11221 cgcgcaggac cccggagccc gtgcagagcc gtacggcacc tgaccgacgt acggccgcac
    11281 cgccgagggc tccggtccgg cgggccccgc acttccccac ggtgtgcggg gcccgcccct
    11341 tcgtcgtact cccgggtcgc tccctgccgg cggtcctccg ccggcaccgg ccgataggct
    11401 caaccgccgt acgcacgagc gaggttgaga cgagagggcg gcgggacatg ggcgtggtga
    11461 tccggagggc gggggaggac gaccgggagc gggtcgtccg gctgctggac gaggccttcc
    11521 aggacgatcc cgtgagcagc tgggtctttc ccgacgtgga gcaccgtcgc cggacccacc
    11581 accggctcat ggccgccttc accgacgccg tgctcgccga cgggcgcatc gacctcaccg
    11641 aggacggcgc ggcctgcgcc ctgtggctgc ccgtgcccgc gggtgagcac gccggcggcg
    11701 gacccgaggg tgacgacggc cccgcccagg tgcgcgaggc cgtcgatccg gagaacgagc
    11761 gcgtcgagct gatagcccgg ctgaccgagg gcgtccatcc gtcggaccgg gcccacgagt
    11821 acctgtggat gatcggcgtg gttccgcggc ggcagggtga gggcctgggt accgcgctca
    11881 tcgagtcggt tctggaccgc tgcgaccgtg aggggctgcc cgcctatctg gaggcgagca
    11941 gcgcccgcgg ccggggcctg tacgaacgtc tcggcttcga gttcaccggt cgggccctgg
    12001 atctgccgga cggcccccgg atgtggccga tgtggcgtga gccgaggaca ccggcgcaga
    12061 cctgacctcg gcgtcgcctc cggtggccgg cgctcgccga gcgggcgcgg ggcggcacgg
    12121 cgttctctcg tggccaccca cgaacccgac ctggtggacg cgcgacggcc gtgtggaggc
    12181 gggacgacgg cccggggcac cgtgacatcg acatcgacac cgacatcgac accgctgccg
    12241 gcgccggtcc gcgccgtgcg gcagcggtac gcgcgccgcg gcggccgggg ccatggtgac
    12301 cgggtcgcgg tgaccgggcc agggtgcgcg ggacacggtg tgcggccacg cgtgcgccgg
    12361 cagacaagac cgcacccggg ccgtcatgga cgccgtgctc ggcggcctgc ggaccgggtg
    12421 cggaaaggga gacaccgcga cccacgcgaa cgcgggtcga aaggcgtgat ccgggatcag
    12481 gccttcttgg tctcccagaa gatcttgtcg atctgggcga tgtagtccag ggccttctga
    12541 ccggtcgccg ggtcggtcga acccttggcg gccgagaggg ccttcagggt gtcgttgacc
    12601 agctggtgca gctccgggta cttctcgaag tgcgggggct tgaagtagtc gctccacagc
    12661 acggagacgt ggtgcttcgc cagctcggcg cgctgctcct tgatgaccgt ggcacgcgtc
    12721 tggaagtgcg ggtcgtcgtt accggccatc ttctcctgca cggccttcac cgactccgcc
    12781 tcgatgcggg cctgggcagg gtcgtacacg ccgcagggca ggtcgcagtg ggcgctgacc
    12841 gtgaccttgg gggcaaacag gcgggaaagc atgaagcgtt ccttcctcgt gatcgtcttc
    12901 tcagggggga cattactccc tgcgagaccc gttttcgcgg gtgcccccgt gggcttagga
    12961 caaaagtccg gggtgagact gagactggtg gaggaaagac cggggaggtg ccgggtgatg
    13021 ccggagtcgt cgcaggagca cgagcgtccg agaggggcgt tgccgttcgg ccccgccgag
    13081 gtgaccgggc cgtcgatggt gcccacgctg caccacgggg acgtgctgct cgtgcactgg
    13141 ggatcgcgcg tccggccggg tgacgtgatc gtgctgcgac accccttcca gcaggacctg
    13201 ctcgtggtca agcgggccgt cgagcggcgc ggagccggct ggtgggtgct cggggacaac
    13261 gccttcgccg gcggggacag caccgactac ggggtggtcc ccgaggagct cgtgctcggc
    13321 agggtgcgct tgcgctaccg gccgctcagg gccggtcagc gctcgccctt cgccgtggcc
    13381 cgctgggcac tggccgcgct caggccggtg ctcggcgacc ggtccgcctc caggcgtttg
    13441 cgggcccggt aggccgcgac gttggcgcgg gtggcgcagc ggtcggagca gtaccgccgg
    13501 gagcggttgg tggaggtgtc caggtaggcg ttgcggcagg gggccgcctc gcacaggccc
    13561 aggcggtcca cgccgtactc ggtgaggtgg aaggcgaggc ccatcgccgc gatggcggcg
    13621 aagccggcgg tcgcgttgga cgggtggtcc gccaggtgca tgtgccacag cgggctgccg
    13681 tcgtcgtcgc ggtggtcgtg gccggagatc tgcgggctca ccgggaactc cagcaggagc
    13741 gagttcagga ggtccacggc gagggtctcg tcgccgccgt cggccgcctc gaagaccgcg
    13801 cgcagccgcc cgcgcaccga gcggaaccgg gtcacgtccg tgtccgtggc gcggcgggcc
    13861 gccgactggt tggtgccgaa gagctcccgg acggcctcga ccgaggtgag ggagtcctgt
    13921 ccccgggccg gctcctcggt gttgacgaga cggacggcat agtccgagta ataggccagt
    13981 tccacttgta gtccttacgg aggggctcta gggtcgtgcc tgcggtcggg taacagctga
    14041 tcgtgcttcc agggtattac gtgacacgtg cgagggaggg gctcgatgac ggacgcggac
    14101 atcaccaccg cgaccacgcc cgcagccgac tggcaggcct ggcagaagag ctgggaccgg
    14161 cagcaggagt ggtacatgcc cgaccgggag gaccgcttcc ggatcatgct ggacatggtc
    14221 gaggccctgg tcggccccgc gccgcgcgtg ctcgacctcg cctgcggcac cgggaccatc
    14281 acggcccggc tgctggaccg gttcccggag gccaccagca ccggtgtgga cctcgatccc
    14341 gccctcctcg ccatcgccga gggcaccttc gcgggcgacg accgggtccg tctggtcacc
    14401 gccgacctca aggacccccg ctggacggcg gagctgccgt acgactccta cgacgccgtg
    14461 ctcaccgcca cggccctgca ctggctccac gccgaacccc tcgcggccct ctacggtcgg
    14521 atcgcggagg tcgtccgcga cggcggtgtc ttcatgaacg cggaccacat gatcgacgag
    14581 acgacgcccc ggatcaacgc ggccgagcgc gcccaccggc acgcgcagat ggacgccgcc
    14641 aaggcgaggg gcgcgctcga ctgggccgag tggtggcggc tcgccgccga ggacccggtc
    14701 ctcgccgggc ccaccgcccg ccgcttcgag atctacggcg agcacgccga cggcgacatg
    14761 ccctcggcgg cgtggcacgc gcgcgtgctg cgcgagaagg gcttcggcga ggcacggccg
    14821 gtgtggtgct cgccgtcgga cacgctgctg ctggccctca agtaaccggt ggacaagccg
    14881 aggggcggta cggagatccg taccgcccct tcgtcgcgcc gtgggtgcgg gcgttcagag
    14941 aaccttggac aggaacgcct tcgtccgctc gtgctgcggg tccgtcagga catcgcgcgg
    15001 gttgcccgac tcgaccacca caccgtcgtc catgaagacc aggctgtcgc cgacctcgcg
    15061 ggcgaagccc atctcgtggg tgacgacgac catcgtcatg ccggactcgg cgaggtcgcg
    15121 catgacgtcg aggacgtcac cgaccagctc cgggtcgagc gccgaggtgg gctcgtcgaa
    15181 cagcatcagc ttcgggtcca tggcgagggc ccgcgcgatg gcgacgcgct gctgctggcc
    15241 gccggagagc tgcgaggggt agttgccggc cttgtcgccc aggcccaccc gctccaggag
    15301 ctggcgtgcg cggtcccggg cctggctccg gctgacgccc ttgacctgga ccggtgcctc
    15361 catgacgttc tcgacggccg tcatgtgggg gaacaggttg aagcgctgga agaccatgcc
    15421 gatgtcccgg cgcttgacgg cgacctcgct gtccttgagc tcgtagagct tgtcgccctt
    15481 ctggcggtag cccaccagct cgccgtcgac gtacagccgc ccggagttga tcttctccag
    15541 gtggttgatg cagcgcagga aggtggactt tcccgagccg gaggggccga tgaggcagaa
    15601 cacctcgccc tgctccacct ccaggtcgat gcccttgagg acctcgaccg cgccgaagga
    15661 cttgtggacg ccctcggcct tcaccatggc ggtcatgccg cgcctcccgt cgtcttggag
    15721 cggttcgaca gggacagcag gttcgccctg atcttctgca tcggggtggc cggcaggctg
    15781 cggctggaac cgcgcgcgta gtagcgctcc aggtagtact ggccgacgct gaagaccgag
    15841 gtcagcagca ggtaccaggc cgcggccagg aacagcatct cggccggggc gccggaggtc
    15901 tggccgatgt cctgggcgac ccggaacaac tcggcgtact ggacgaccga caccagtgag
    15961 gtcgtcttca gcatgttgat gacctcgttg ccggtcggcg gcacgatcac gcgcatcgcc
    16021 tgcggcacca cgatccggcg cagtgtcttg gtgtggctca tgccgagcgc gtgcgccgcc
    16081 tcggtctggc cctcgtcgac cgcgagcaga ccggcgcggc agatctccgc catgtacgcg
    16141 gcctcgttga ggccgaggcc gagcagcgcc gtcaggaacg gcgtcatgaa gtccgaccac
    16201 tcgtcgcggt agaacgggcc gaggttgatg tactcgaaga ccaggcccag gttgaaccag
    16261 acgaccagct gcaccaggac cggcgtgccg cggaagaacc agatgtagaa ccacgcgatg
    16321 gacgaggtca ccgggttctt cgacagccgc atgacggcga gcatgatgcc gccgacgacg
    16381 ccgatcagca tcgccaggac ggtgatcagg agcgtcttgc ccatgccggt caggacgcgg
    16441 tcgtcgaaga agtagtccgg gatcgcaccc cagttgatct tgccctggga gaacgcgtac
    16501 acgacggcgg ccagcagcgc gatcgcgacg accgcggaga tgtaccgccc gtagtgccgg
    16561 accggaatgg ccttgatggc ttccggtccg gccggcgggg tgtcggccgg gccgcccgcc
    16621 gtcttgtcga tgtcaacagt cacggatgtt gcctttcagt gcccgccgcg cggtcacttg
    16681 ccgccgttga tggtggcctc cgtgacggcg ccttccgcca cgccccactt gtccatgatc
    16741 ttcttgtact cgccgttggc gatgaccgcg tccagcgccg ccttcagggc gtcccgcagc
    16801 tgcgcgttgt ccttggcgac cgcgatgccg tacggggcgg cctcgacctg ctcgccgacg
    16861 agctggaagt cgttgccgcc gccggaggtc ttcaccgcgt acgccgcgac cgggaagtcg
    16921 gaggagccgg cggcggcgcc gcccgcgcgc aggcgggtct gggcctgctg gtcgttgtcg
    16981 aaggcctcca tggagatctt cttgccggcc gggcacttct cgttctcggc cttggcgagg
    17041 tcctcggaga ccgtgccgcg ctggaccacg agcttcttgc cgcacaggtc ggaccaggtc
    17101 ttgatgccct ggtcgtcgcc cttcttggtg tagatcgaga caccggcggt gaagtagtcc
    17161 acgaagtcga cgccctggcc gaccttcttg ccggtgtcgg agtcgacgcc ctcctgccgg
    17221 tccttggtgt cggtcatcgc ggacatggcg atgtcgtagc gcttggagcg cagaccggtg
    17281 atcagcgtgt cgaaggtgcc gttctcgaac tcgaacttca ccccgagctg cttgcccatc
    17341 gcgtccgcga ggtcggggtc gatgccgacc gtcttgccgg acttgtcctt gaactcgacc
    17401 ggggcgtagg cgatgtccga gccgaccttg acgacgccct tgtcgcggat ggactggggg
    17461 agcctgtcgg ccagcggagc gcccgcggcg gactggctgt cgctgccgga gtcgctcttc
    17521 tcggtctggt cgccgcatcc ggtgagcagc agggcgcctg cgaccgcgat cgcaccgacc
    17581 gctgctagcc gggactgcgc ggcggtcgta cgacgggtgg agcgtgcggt catggtggtt
    17641 cctccggcgg atgaaaggag atgccgatgg ggacggtgga attccggtgg ggctgggcgc
    17701 cgtccggggg accggcaggc gccgtgggtc gacgagtgca cacgccttcg agtgtcgcga
    17761 cctcgtgtga ttacggcatc ttgccattcg gactcggcca ttcagggggg acggcatgtc
    17821 aaaatcggat aacgggtcac cccccgaacc gcaccaggtc ggtacatccc gtccgaaccc
    17881 ttacgggaat cgggccttcc ggccggaaaa tcttcggcat tccgctgaat gcgggcacgg
    17941 ttcggcagtg tgcgcggctg ttgaaagccg gttccgcggg cctgtcaagg gctcgaggga
    18001 agttgtcctg atccccggct atgagccatg tcaccggcat gtggcgttcg aggtccgaca
    18061 tgtgagcttg cccttatcgg actcgtcgag gggggcgtcc gtcgggtaag aaggttcttt
    18121 acacccctca tcaggggctc agggcgcgtg tgcggcgcgc ccgtcgcgca gggcccatgt
    18181 ggcgcggaca gccatcttcc tgcgcggtgc ccgcccattc ctcaccagga gtggacaaac
    18241 cctcaaacca tgaactctta aggggtaaga caaagtggca gcggagatcg tcaatcctcg
    18301 cagcgacagc gaagccggta cggaacagga ggcgggggag cccctcgact ccttcgaccc
    18361 ggcgttcgct ctgcatcgcg gcggcaagat ggccgtgcag gccaccgtgc cgatccgtga
    18421 caaggacgac ctgtccctgg cgtacacgcc cggcgtcgcg aaagtgtgca gcgcgatcgc
    18481 cgagcagccc gacctggtgc acgactacac ctggaagtcg tcggtcgtgg cggtcgtgac
    18541 ggacggtacg gccgtcctcg ggctcgggga catcggaccc gaggcctccc ttccggtgat
    18601 ggaggggaag gcgatcctct tcaagcagtt cggcggtgtg gacgcggtcc cgatcgcgct
    18661 ggactgcacg gacgccgacg agatcgtcga gaccgtggtg cggctcgctc cctccttcgg
    18721 cggtgtgaac ctggaggaca tctcggcgcc gcggtgcttc gagatcgagc gcaagctcca
    18781 ggagcgcctc gacatcccga tcttccacga cgaccagcac ggcacggcgg tcgtgacact
    18841 ggcggcgctg cgcaacgcgg cgcggctgag cgggcggacg ctgggtgagc tgcgggcggt
    18901 gatctcgggc gccggcgcgg ccggtgtcgc catcgccaag atgctggtcg aggccggcat
    18961 cggggacgtg gcggtcgccg accgcaaggg cgtcgtgtcg gccgaccggg acgacctcac
    19021 cccggtcaag cgggagctgg cctccttcac caacaaggcc gggctgtccg gcacgctgga
    19081 ggcggccctg tcgggcgccg acgtcttcat cggcgtctcc ggcggtacgg tgccggagcc
    19141 ggcggtggcc tcgatggccg agggcgcgtt cgtcttcgcg atggccaacc cgaaccccga
    19201 ggtgcatccg gaggtcgcgc acaagtacgc ggcggtcgtc gcgacggggc gctcggactt
    19261 cccgaaccag atcaacaacg tgctggcgtt cccgggcatc ttcgcgggcg cgctgcaggt
    19321 gcgggcttcg cggatcaccg agggcatgaa gctcgctgcg gccgaggcgc tggcctccgt
    19381 ggtgggcgac gacctcgccg cggactacgt catcccctcc ccgttcgacg agcgggtcgc
    19441 cccggccgtc acggcggcgg tggcggccgc cgcccgcgcc gagggtgtcg cacgccgatg
    19501 acggtgtgac gcaccgcggt ccgacggccc cgccctcacg ggcggggccg tttccgtggc
    19561 ggggagcgga gcggccgggc ggtgcgtcgc cggtcggccg ggcggggcac cgctgacaag
    19621 agggcgtgtg tcacagggcg ccacggttcc ggatggccgg tgcggaacct atcgtcaagg
    19681 tcatgttcgc tgtctacgcc gcccgaatcg accgcgacca gccgctgacc ggcctggagt
    19741 tgggggagcg tccggctccc gaggcccgcc ccggctggag cgtcgtcgat gtcagggccg
    19801 cttccctcaa ccaccacgac ctgtggtccc tgcgcggtgt cggcctcccc gaggaccggc
    19861 tgccgatgat cctcggctgc gacgccgcgg gtgtcgacga ggacggcaac gaggtcgtcc
    19921 tgcactccgt gatcgggcag accggccacg gcgtcggccc cgaggagccc cgctcgatcc
    19981 tcaccgagcg ctacccgggg acgttcgccg agcgggtcgc cgtgcccacc tggaacatcc
    20041 tgcccaagcc gaaggagctc tccttcgagg aggcggcctg tctgccgacc gcctggctga
    20101 cggcgtaccg gatgctgttc accaacgccg gggtgcgtcc cggtgactcc gtgctggtgc
    20161 agggcgccgg cggtggggtc gccacggccg cgatcgtgct cggcaaggcc gcgggactgc
    20221 gggtcttcgc gaccagccgg gacgaggcca agcgcaagcg ggccgtggag ctgggagccg
    20281 tggaggccgt cgagccgggc gcacggctgc cgcagcgggt cgatgccgtg atcgagacgg
    20341 tgggcgccgc cacctggtcc cactcggtga agtcgctgcg gccgggcggc acgctggtca
    20401 tctccggcgc gaccagcggc gaccggccct cgcacgccga gctgacccgg gtcttcttcc
    20461 tggagctcag gatcgtcggc tcgacgatgg gcaccaagga cgagctggag gatctgctgt
    20521 ccttctgcgc cgccaccggc gtgcgccccg tcatcgacga ggtgctcccg ctggaccggg
    20581 cccgcgaggg cttcgagcgg atggcctccg gcgaacagtt cggcaagatc gtgctcagcg
    20641 gatcctgagc ctgcggttct ccccttccgc cacggcgggt ccggtcttcc gggcccgccg
    20701 ttcgtgtgct tcgcccgtcg cccggacctt gtcaggacgt ctgatgtcaa tgtgggttga
    20761 cagtcgatgc ctgtcaatct atgttgacat catgagtgaa gctacagatc tcgccgcacg
    20821 tgcgggtgat cgcgaccccc gggtcgggct gcgcgccgtc gcggccctgc gcaggctcct
    20881 ggagcagctg gaggcggtgc aggtgcgcgc cgctcgccat cagggctggt cgtggcagga
    20941 gatcgcctcg gagctcgggg tcagcaggca ggccgtgcac aagaagtacg ggaggcattg
    21001 atgttcgagc ggttcacgaa ggacgcgcgg gccgtggtgc agggagcggc cgaacatgcg
    21061 gaggaggcgc gggcgcagac cgtcgaggcc gagcacctgc tgctcgccct gctggaccgc
    21121 gagggcagtc gtgcctcctt cgcgctggcg gccctcgggg tcgg
//
