LOCUS       NZ_CP012382            21092 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5302264
            Orig. end                         :: 5323356
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21092
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="12"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21092
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21092
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11092](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11092
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(1331..1344)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            complement(1391..2113)
                     /locus_tag="SAM23877_RS23710"
                     /old_locus_tag="SAM23877_5001"
     CDS             complement(1391..2113)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973759.1"
                     /locus_tag="SAM23877_RS23710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5001"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_053136851.1"
                     /transl_table=11
                     /translation="MDHLASASLASLWDEVSGTQPDPDLWVVIATLVAALAVVVPHGLW
                     RIARNAVTIAHEGGHGLVALLTGRTLTGITLHSDTSGLTVSRGKPHGLGMILTAVAGYT
                     APPLLGLGGAALLASGRITLLLWVATALLVALLVMVRNAYGVLTVVLTGATFLLVSWLA
                     GPQVQAAFAYAAVWFLLLGGVRPAFELQAKRARGGAGDSDADQLARLTHAPAGVWFFLF
                     HAVSLCSLVGGGRWLLEL"
     gene            2216..3031
                     /locus_tag="SAM23877_RS23715"
                     /old_locus_tag="SAM23877_5002"
     CDS             2216..3031
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="SAM23877_RS23715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5002"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_053136853.1"
                     /transl_table=11
                     /translation="MCGRYAASRRPEDLAGIFEIEKWEPEETLEPDYNVAPTKEVYAVL
                     DRPLKDVEDPKPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPSYRRAFATRR
                     CILPADGYFEWVTGKQERDLEVEGRKKRPRKQPYFVTPADGSVFAMAGLYEFWRDKTLP
                     DDHPQAWWVTCSVITTEAETTPLAVAPADGPHALADIHPRMPLMLTPDRWDDWLDPART
                     DPDELTSLLAPPPAGLMRAFPVGTAVSNVRNNGPELLKELEGPEEGTLF"
     gene            3033..3686
                     /locus_tag="SAM23877_RS23720"
                     /old_locus_tag="SAM23877_5003"
     CDS             3033..3686
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326973.1"
                     /locus_tag="SAM23877_RS23720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5003"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_053136857.1"
                     /transl_table=11
                     /translation="MSSENTQTETVETDTGPARVTWHPAKRPRLVLGLSHGAGGGIEAR
                     DLRALAAVLPTHGVTVALVEQPWRVAGRKLAPAPKTLDAGWRGIWPALAAPGLPVISGG
                     RSAGARVACRTAAELGARAVLALSFPLHPPGKPEKSRAEELLGAGVPTLVVQGGNDPFG
                     RPEEFPGAPEGTYGLIEVAHGDHGFAVPKRAETTQERALEVITDGVVEWVGSLG"
     gene            4007..4690
                     /gene="sigR"
                     /locus_tag="SAM23877_RS23725"
                     /old_locus_tag="SAM23877_5004"
     CDS             4007..4690
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="SAM23877_RS23725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5004"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_003973756.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTEHGQAEQPEGRGTGAESTAERSARFERDALEFLD
                     QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK
                     QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKQALQAIPEEFRIAV
                     YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEA
                     KGSGS"
     misc_feature    4029..4044
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     gene            4687..4998
                     /gene="rsrA"
                     /locus_tag="SAM23877_RS23730"
                     /old_locus_tag="SAM23877_5005"
     CDS             4687..4998
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="SAM23877_RS23730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5005"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_053136860.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPGDLRSKVMGRIDLIRSGQSVPEHDVTAAPPAPQES"
     gene            5145..6482
                     /locus_tag="SAM23877_RS23735"
                     /old_locus_tag="SAM23877_5006"
     CDS             5145..6482
                     /EC_number="3.1.4.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973754.1"
                     /locus_tag="SAM23877_RS23735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5006"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_053136863.1"
                     /transl_table=11
                     /translation="MDAVPARARVYVAGVVLAALVCLRPLPEADAPWWAVSLLAGLCAG
                     AELAARSARSCFFGTCYPVLLAGAFLLPPAAAALVALPGALLSPVAQRPVALRRVWRAA
                     QLTLAVWAAARVHGELGGPDAVVAADFPYALVPAGAAALAFCLVLTLLDGGISVLADRV
                     PARRAWRGLFSRSPAPIAVHGLAGLMMAVLWRSPYGAVAALLVLLPMCVAWWAFAQYHR
                     ERAAHQATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMDDERVETLRFAGILHD
                     VGKLGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIRFLGEARAAVLHHHERLDGS
                     GYPYGLTGDRIPESARVVAVADAFDAMTSTRSYRRARPVAAAVAELQRCAGAQFDPRMV
                     GALVRALGRHGWRPAVTADGTPAGPADVIPGSRGEGVRDGVGRGAR"
     misc_feature    complement(6523..6535)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            6547..7866
                     /locus_tag="SAM23877_RS23740"
                     /old_locus_tag="SAM23877_5007"
     CDS             6547..7866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326969.1"
                     /locus_tag="SAM23877_RS23740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5007"
                     /product="HD domain-containing protein"
                     /protein_id="WP_079030787.1"
                     /transl_table=11
                     /translation="MSAYRPRPPAAHTLVPVCAGLVALASLASVLWSGPVDRPVALAFG
                     VLVVLGELTRGTGAGAREAAPLGAAGAMAYALLGEVAGRPMQHGAGQTVAVVLAASLLG
                     SVPRIARGGGPVLDPLARRVLTVAFAAVCFRPLHNQGVFHDWSGPAHVLLLVALLALTA
                     LCEALLAAAPAHARTGWPFGPLLREELRGMVGITSAVCATGAVMALAVAVAGLWALPVL
                     CVPLLLTHLSYRRYAAVRATYRQTIASLARATEIAGYTPAGHARRVAELSGAVGRDLGL
                     SGADLTVLEYAALMHDIGQLSLVDPVPAGATACLPRAEQRRIALLGGAVVRQTGVDAAV
                     AVVVERQADPCREQPVAARIVRAVNAYEEKARDAGPGGGLKALEELRLAVADDYAPDVV
                     EALARVLSRQGGTTRERLRRGQGRDEDGQSYRARYWVTHG"
     gene            7970..8950
                     /locus_tag="SAM23877_RS23745"
                     /old_locus_tag="SAM23877_5008"
     CDS             7970..8950
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="SAM23877_RS23745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5008"
                     /product="hypothetical protein"
                     /protein_id="WP_053136866.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRDIGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRTPGNATDAGEPLGMELGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTTAGHAYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPAALVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9102..9752
                     /gene="def"
                     /locus_tag="SAM23877_RS23750"
                     /old_locus_tag="SAM23877_5009"
     CDS             9102..9752
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="SAM23877_RS23750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5009"
                     /product="peptide deformylase"
                     /protein_id="WP_053136869.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDDGFVVDTEECEERETAWRERGTSRPIT
                     VVGNPVLHKECEDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIGVAKKVFVYDCPDD
                     EGVRHVGVVCNPRLVELPADRRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEQGNPV
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKEALRQMAENEPRYPVVAND"
     gene            10001..11092
                     /gene="cyc1"
                     /locus_tag="SAM23877_RS23755"
                     /old_locus_tag="SAM23877_5010"
     CDS             10001..11092
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="SAM23877_RS23755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5010"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_079030788.1"
                     /sec_met_domain="T1TS (E-value: 4.6e-62, bitscore: 209.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFPHGTTAAPTAIAVPPSLRLPVIEAAFPRRLHPYWPRLQEKT
                     RTWLLEKRLMPADKVAEYADGLCYTDLMAGYYLGAPDEVLQAIADFSAWFFVWDDRHDR
                     DIVHDRPGAWRRLRNQLHAALDSPGDHLHHEDTLVAGFADSVRRLYAFLPPPAQWNARF
                     TRHFHAVIEAYDREFHNRTRGIVPGVAEYLELRRLTFAHWIWTDLLEPSAGCELPDAVR
                     KHPAYSRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHGLTLEESIGEVRRR
                     VEECITEFLDVEQDAMRFADELDDGTVRGKELSGAVRAGVGNMRNWFSSVYWFHHESGR
                     YMVDNWDDRSTPPYVNNEAAGEK"
     gene            11089..12504
                     /locus_tag="SAM23877_RS23760"
                     /old_locus_tag="SAM23877_5011"
     CDS             11089..12504
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326965.1"
                     /locus_tag="SAM23877_RS23760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5011"
                     /product="cytochrome P450"
                     /protein_id="WP_053136875.1"
                     /sec_met_domain="p450 (E-value: 3.3e-68, bitscore: 229.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQSSPESPASAGQSATASPAVRDEATPELRRPPVAGGGVPLLG
                     HGWRLARDPLAFMSQLRDHGDIVRIKLGPKTVYAVTAPELTGALALSPDYHIAGPLWES
                     LEGLLGKEGVATANGPLHRRQRRTMQPAFRLDAIPAYGPIMEEEAHALAERWQPGRTVD
                     ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA
                     NREFNNALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI
                     LTPGSETIASTIMWLLQALADHPEHADRIHDEVRAVTGGRPVAFEDVRKLTHTNNVIVE
                     AMRLRPAVWVLTRRTVVETELGGYRIPAGSDIIYSPYAIQRDAKSYADNLRFDPDRWIP
                     ERATDVPKYAMKPFSVGNRKCPSDHFSMAQLTLITAALASKYRFEQVAGSNDAVRVGIT
                     LRPHDLLVRPVAR"
     gene            complement(12508..13476)
                     /locus_tag="SAM23877_RS23765"
                     /old_locus_tag="SAM23877_5012"
     CDS             complement(12508..13476)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030121.1"
                     /locus_tag="SAM23877_RS23765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5012"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_053136878.1"
                     /transl_table=11
                     /translation="MLQNVAAVLLDGAHPFELGVVCEVFGVDRSDEGLPRYDFAVVSAE
                     GPELTTHVGGLTVSTPYGLERLEEADLITVPAGSDFARREYPPELLDALRRAVERGARV
                     LSVCSGVFVLGAAGLLDGRRCAVHWHHAAELARQYPRVSVAPDVLYVDEDPVITSAGTA
                     AGIDACLHIVRKEQGTEVANKIARRMVVPPHRDGGQAQYIERPLPRSSCDTVGEVLSWM
                     EQHLDEEVTVDQLAARARMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETM
                     DAIAWRTGFGTAAALRHQFVRALDTTPHAYRRTFRGPEAAA"
     gene            13569..13823
                     /locus_tag="SAM23877_RS23770"
                     /old_locus_tag="SAM23877_5013"
     CDS             13569..13823
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973747.1"
                     /locus_tag="SAM23877_RS23770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5013"
                     /product="hypothetical protein"
                     /protein_id="WP_053136881.1"
                     /transl_table=11
                     /translation="MTGNQMEALIGMLVTFGLLVLMVLPSAIGIVRERRIDRQLREARE
                     NRREGERPRPTQKSSDRSTVPSTATWYAEGRRSKKLVSS"
     gene            complement(13736..14743)
                     /locus_tag="SAM23877_RS23775"
                     /old_locus_tag="SAM23877_5014"
     CDS             complement(13736..14743)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947116.1"
                     /locus_tag="SAM23877_RS23775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5014"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_053136884.1"
                     /transl_table=11
                     /translation="MNTKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWHVEEVDLHSD
                     VTDLAKLSPMEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAV
                     HVQFYLTLLDTYLPDPDDRAAAFAAVENIPSIREKAEFCFRWMDSVESIDRLETRADRR
                     RFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFDVV
                     DTVRKEEPELFDDQLRQEVTDMLREAVEAELQFARDLCGDGLPGMNTDSMREYLECVAD
                     QRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLSEDF"
     gene            complement(14743..17115)
                     /locus_tag="SAM23877_RS23780"
                     /old_locus_tag="SAM23877_5015"
     CDS             complement(14743..17115)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444560.1"
                     /locus_tag="SAM23877_RS23780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5015"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_053136888.1"
                     /transl_table=11
                     /translation="MTIAPADPASATPVTATGEPDGPGAALLRTLTVLTADLPGADPGR
                     VAAAALRGRSARADEAELRELATEAAAGLISEDPVYSRLAARLLTIGIRAEAASQGVAS
                     FTESVATGHREGLIADRTAAFVRLHADRLDALIDPAADDRFGYFGLRTLHSRYLLRHPI
                     TRKVVETPQYFMLRVAAGLAEDDTARAADEVAALYGLMSRLDYLPSSPTLFNSGTRHAQ
                     MSSCYLLDSPKDELDSLYDRLHQVARLSKHAGGIGIAYSRIRSRGSLIRGTNGHSNGIV
                     PFLKTLDASVAAVNQGGRRKGAAAVYLETWHADIEEFLELRDNTGEDARRTHNLNLAHW
                     VPDEFMRRVDADGQWSLFSPADVPELVDLWGAEFDAAYREAEAAGLARRTLPARELYGR
                     MMRTLAQTGNGWMTFKDTANRTANQTAEPGHVVHSSNLCTEILEVTDDGETAVCNLGSV
                     NLGAFVDVAAGDLDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMG
                     LQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSTDLAERNGPLPAWEKTRTARGVL
                     HPDHYGVETTWPERWAALRERMATTGLRNSLLLAIAPTATIASIVGAYECIEPQVSNLF
                     KRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFSWIPEDVRALYRTAW
                     EIPQRGLIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPA
                     TRIARAAARATVPAQQAPDPEAVACSLENPESCEACQ"
     regulatory      complement(17237..17415)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17375..17389)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(17406..17420)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17443..17949)
                     /locus_tag="SAM23877_RS23785"
                     /old_locus_tag="SAM23877_5016"
     CDS             complement(17443..17949)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="SAM23877_RS23785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5016"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_053136891.1"
                     /transl_table=11
                     /translation="MDFVIRRATAEEYDTLGEITARAYLGDGLLDFGEDDAYLHELRAV
                     ARRAAAAEVLVAASDGGVLGGVTFVPRGGPMADIARPGEAEIRMLAVAREARGRGAGEA
                     LVRACVDRARSVPGCARVVLSTQRTMHGAHRLYARLGFTRTPERDWNPLPKLDDFTLLT
                     YELTL"
     gene            complement(18022..19632)
                     /locus_tag="SAM23877_RS23790"
                     /old_locus_tag="SAM23877_5017"
     CDS             complement(18022..19632)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444565.1"
                     /locus_tag="SAM23877_RS23790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5017"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_053136894.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFIFFFLLVTAMGFLAARWRRAENEHSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGLGGG
                     EDTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDDIFAAAGDKFTESGKGSLTPDHGGQWTYATLALGSALALFMYPHSITATLSSRSREV
                     IRRNTTILPLYSLMLGLLALLGFMAIAAGVKVENGQLAIPQLFENMFPDWFAGVAFAAI
                     GIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPAQETKVSKLVSLLVKVGALVFVLGM
                     DKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLGGWAVGMVYGTVAAYGVASPT
                     QKHFGGSSDEIPGIGEIGYIGLTAFVLNVLVTVVLTFVMRALKAPEGIDETKPGDYTAD
                     AGDPGVEVELPPATAGTSH"
     gene            complement(19629..19886)
                     /locus_tag="SAM23877_RS23795"
                     /old_locus_tag="SAM23877_5018"
     CDS             complement(19629..19886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973741.1"
                     /locus_tag="SAM23877_RS23795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5018"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_079030392.1"
                     /transl_table=11
                     /translation="MSQAPEVSRGPVVTPVRVVIGLCLVAPFVAMLWVGSYAKTDPAFI
                     GIPFFYWYQMAWVLISTALTMIAYKLWQRDQRARREGGAK"
     misc_feature    complement(19958..19972)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            complement(20067..20831)
                     /locus_tag="SAM23877_RS23800"
                     /old_locus_tag="SAM23877_5019"
     CDS             complement(20067..20831)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="SAM23877_RS23800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_5019"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_053136900.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEGGATVRTARVPKYYRLKKHLLDMTRTQAPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SQDRTGQPVEWVRSVYRGDRYKFVARLKRPQD"
     misc_feature    20963..20978
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.33"
                     /tool="antismash"
ORIGIN
        1 accctccacg ccgaggccga tgatcgcgcc ggccgtggcc atgcggtggt cctcgtaggt
       61 gtggaagacg ccgccgtgca gccggcgcgg gcggatgtgc aggccgtcgg cggtctcggt
      121 gacgtcaccg cccagttcgt tgatctcctt ggtgagcgcg gccaggcggt ccgtctcgtg
      181 cagacgcagg tgcgccaccc cgcgcagcgt cgagggggag tccgcgaggg cggcgacggc
      241 cgcgatgccc ggggtgagtt cgccgacctc gccgaggtcg acgtcgatgc cgtgcacagc
      301 acccgatccg gtgaagacga gcccgtagtc cgtcagttcg cagtcaccgc ccatctcggt
      361 gaagatctcg cggagccggt cacccggctg ggtggtgcgg gacggccagt ccgggatcac
      421 gaccttgccg ccggtcacca gcgccgccgc caggaagggc tgggcgttgg agaggtccgg
      481 ctcgatcgtc aggtcgcggc cgagcagcgc gcccggcgtg acccgccaga cgtcgggctc
      541 gccgccggac tccggggtgt cgacctgggc gccgaccgcg cgcagcatgt cgacggtcat
      601 gcggatgtgc ggcatggacg gcagcgcgga gccggtgtgg cggacctcga cgccctggtt
      661 gaagcgcggt ccggacagca gcagggcgct cacgaactgc gaggacgacg acgcgtcgat
      721 ctcgaccggg ccgccctcca gcgccccgcc cccgtgcacg gtcaacggaa gcgcaccccg
      781 cgcgtcgtcg tcgatacggg cgccgagggc gcgcagcgcg tcgatcacgc cgtgcagggg
      841 gcgctcgtac gaacgcgggt cgccgtcgaa gcggatggca ccgtcggcca gcgtggcgac
      901 cggcggcagg aagcgcatga ccgtgccggc gttgccgacg tcgaccgtgg ccggcccgcg
      961 caggcccgcc gggatgaccc gccagaactc gccggtgccg tccgggccga cgccctcctc
     1021 gatctcgacg cccatcgcgc gcagggcacc ggccatcagc agcgtgtccc gggagcgcag
     1081 cggacggcgc agccagccgg gctcggaggc cagggcggcc agcaccaggg cgcggttggt
     1141 gaccgacttg gacccgggca cgtggacggt cgcgtcgacg gccccgctcg cgtgcggggc
     1201 gggccagagg gcggtgtgcg cggggttcac ggtcatgcgc cccactttaa tggctgagga
     1261 cgaccggaga tcttgatcaa aagcggcgaa acctgaccga aagtgcgtga gggcacttgc
     1321 cgtgcatata tgcgtgggca tgcggagcag gcggggaacg cagggacgcc ggagaaacaa
     1381 cgcaccccgt tcacagctcc agcagccagc gccctccgcc caccagtgag cacagcgaca
     1441 ccgcgtggaa caggaagaac cacacccccg ccggcgcgtg cgtcagccgg gccagctggt
     1501 ccgcgtccga atcgccggcg ccgccgcgcg cacgcttcgc ctggagctcg aaggccggcc
     1561 gcaccccgcc gaggagcagg aaccacaccg ccgcgtacgc gaacgccgcc tgcacctgcg
     1621 gaccggccag ccaggacacc aggaggaagg tggcgccggt gagcaccacc gtcagcaccc
     1681 cgtaggcgtt gcggaccatc accagcaggg cgacgagcag cgccgtcgcc acccagagca
     1741 gaagggtgat ccgtcccgag gccagcagag cggcaccgcc gagtccgagc agcgggggag
     1801 cggtgtagcc ggcgaccgcg gtgaggatca tcccgagccc gtgcggcttg ccccggctga
     1861 cggtcaggcc gctggtgtcc gagtgcaggg tgatgccggt gagcgtgcgc ccggtcagca
     1921 gggcaacgag cccgtggccg ccctcgtggg cgatggtgac ggcgttgcgg gctatccgcc
     1981 acaacccgtg cggcacgacg accgcgagcg cggcgaccag ggtcgcgatc accacccaca
     2041 ggtcgggatc gggctgggtg ccggagacct cgtcccagag ggaggcgagc gaggccgatg
     2101 cgaggtggtc catgtccggt gggggctcct cgtgcgatcg gtcgagcggg tggcgcgcag
     2161 cgcctcgtcg acgggtggtg gccggaagac gggcgggcct ggcagtgtgg cacgtatgtg
     2221 cggacggtat gcggcgagtc gtcgacccga ggatctcgcg ggaatcttcg agatcgagaa
     2281 gtgggagccc gaggagacct tggagcccga ctacaacgtg gccccgacca aggaggtcta
     2341 cgcagtcctc gaccgccccc tgaaagacgt cgaggacccg aagccggttc gccagctgcg
     2401 gaagctgaag tggggcctcg tcccctcctg ggccaagacg cccgagggcg gcgcccggat
     2461 gatcaacgcg cgcgcggaga ccgtccacga gaagccgtcc taccgtcgtg ccttcgccac
     2521 ccggcgctgc atcctgcccg ccgacggcta cttcgaatgg gtcaccggca agcaggagcg
     2581 cgacctggag gtcgaggggc gcaagaagcg gccccgcaag cagccgtact tcgtgacccc
     2641 ggccgacggg tccgtgttcg ccatggccgg gctctacgag ttctggcggg acaagacgct
     2701 gccggacgac cacccgcagg cctggtgggt gacgtgctcg gtgatcacca cggaggccga
     2761 gaccacgccg ctcgcggtcg ccccggccga cggaccgcac gccctggccg acatccaccc
     2821 gcggatgccg ttgatgctga ccccggaccg gtgggacgac tggctcgacc cggcgcgcac
     2881 ggaccccgac gaactgacct cgctgctggc gccgccgccc gccgggctga tgcgggcgtt
     2941 ccccgtcggc acggccgtga gcaacgtgcg caacaacggc ccggagctgc tgaaggagct
     3001 ggagggaccg gaggagggca cactcttctg acgtgagcag cgagaacaca cagaccgaga
     3061 ccgtcgagac cgacaccggc cccgcccgcg tcacgtggca cccggcgaag aggccccgcc
     3121 tcgtgctggg cctgagtcac ggcgccggcg gcggcatcga ggcgcgcgac ctgagggcac
     3181 tggcggccgt actgcccacg cacggcgtga ccgtcgccct cgtcgagcag ccctggcggg
     3241 tggccggccg gaagctcgcg cccgcaccga agaccctgga cgccggctgg cggggcatct
     3301 ggcccgcgct ggccgcgccc gggctgccgg tgatctcggg cggccgcagc gccggcgccc
     3361 gcgtcgcctg ccgcaccgcc gccgaactgg gcgcccgtgc cgtcctcgcc ctgagcttcc
     3421 cgctgcaccc gccgggcaag ccggagaagt cccgcgcgga ggaactgctc ggggccgggg
     3481 tgccgaccct cgtcgtccag ggcggcaacg acccgttcgg ccggccggag gagttccccg
     3541 gggccccgga gggcacctac ggcctgatcg aggtggcgca cggagaccac ggcttcgccg
     3601 tgcccaagcg agcggagacc acccaggaac gggccctgga agtgatcacc gacggggtag
     3661 tggagtgggt cggctcactc gggtgacggc ccgggaatga ccggcggacg accactgttg
     3721 tggcggacat accgtgctgg gcaccagcaa cgacgccgta cgagaggaag tccgccgcat
     3781 ggcatcagcc ttctgcccga gtcgcagcag ccgcgccgac ctggactgga cagtgctgca
     3841 cgcggcgaag accgctcccg tccgggcgac gggcggaccc gaccggcagg cgtcacctgc
     3901 cgcgggacaa gcgccctcga ccgttggaca agcgttcccg accgcaggtc gtctatcctc
     3961 cgattcgagc ggggccgcat tcggctccgt gacgtcactg gaggaggtgg gtccggtcac
     4021 tgggaccgac gcagggaccg aacacggcca ggcggagcag cccgagggcc ggggcacggg
     4081 cgcggagtcg accgcggagc gcagcgcgcg cttcgagcgg gacgcgctgg agttcctcga
     4141 ccagatgtac tcggccgcgc tgcgcatgac gcgtaacccg gccgacgccg aggacctggt
     4201 gcaggagacc tacgccaagg cgtacgcgtc cttccaccag ttccgcgagg gcaccaacct
     4261 caaggcgtgg ctgtaccgca tcctcaccaa caccttcatc aactcgtacc gcaagaagca
     4321 gcgcgaaccc cagcgcagcg cggccgagga gatcgaggac tggcagctcg cgcgcgccga
     4381 gtcgcacatg tcgacggggc tgcgctccgc ggagtcgcag gcgctggacc acctgcccga
     4441 ctcggacgtg aagcaggcgc tgcaggcgat ccccgaggag ttccgtatcg ccgtgtacct
     4501 ggcggacgtc gagggctttg cctacaagga gatcgccgac atcatgggga cacccatcgg
     4561 tacggtgatg tcccggctgc accgtggacg gcgtcagctg cgcggcatgc tggaggacta
     4621 cgcccgcgac cgcggcctgg tcccggccgg tgccggagag tcgaacgaag cgaaaggctc
     4681 ggggtcatga gctgcggaga gccgcacgag acggattgca gcgaaatcct cgatcatctc
     4741 tacgagttcc tcgacaaaga gatgccggac tcggactgcg tgaagttcga gcaccacttc
     4801 gaggagtgct cgccgtgcct ggagaagtac gggctggagc aggccgtgaa gaagctggtc
     4861 aagcggtgct gcgggcagga cgacgtaccg ggtgacctgc ggtccaaggt catgggccgg
     4921 atcgacctga tccgctccgg gcagtccgtg cccgaacacg acgtcaccgc cgcgccgccg
     4981 gctccgcagg agtcctgagg cggtccggac cggtccccgc ccgtgacgtg gcccgtcacg
     5041 ggccacgtca ctcgtacgtg ctaatccgcg ggttatctgc ccgcgttccc cctgtcgccg
     5101 tcctaggctc cggagcctga caggcatggc cgggggaggg gctcatggac gccgtaccgg
     5161 cacgggcgcg ggtgtacgtc gccggcgtgg tcctcgccgc tctggtctgt ctgcgcccgc
     5221 tgccggaggc ggacgcgccc tggtgggccg tgtcgctgct cgccgggctg tgcgcgggcg
     5281 cggaactggc cgcccgttcg gcccggtcct gtttcttcgg cacctgctac cccgtcctgc
     5341 tcgccggggc cttcctgctg ccaccggccg ccgccgcgct cgtggcgctg cccggggccc
     5401 tgctgtcgcc cgtggcgcag cgccccgtcg cgctgcggcg cgtctggcgg gccgcgcagc
     5461 tgacgctcgc cgtgtgggcg gccgcacggg tgcacgggga gctcggcggg ccggacgcgg
     5521 tcgtcgcggc cgacttcccg tacgcgctgg tgccggcggg ggccgcggcg ctggcgttct
     5581 gcctggtgct gaccctgctg gacggcggta tctcggtgct ggcggaccgg gtgcccgcac
     5641 gccgggcctg gcgcgggctg ttctcccggt caccggcgcc gatcgccgtg cacggtctcg
     5701 ccgggctgat gatggccgtc ctgtggcgca gcccgtacgg ggccgtcgcc gcgctgctcg
     5761 tgctgctgcc catgtgcgtg gcgtggtggg cgttcgccca gtaccaccgg gagcgggccg
     5821 cccaccaggc gaccatccgc gccctggtgc aggccgtcga catcaaggac ggctacacgc
     5881 gcgggcacag cgagcgcgtc ggacaggcat ccatgatgat cgcccgggag ctgggcatgg
     5941 acgacgagcg cgtcgagacg ctccgcttcg ccgggatcct gcacgacgtg ggcaagctcg
     6001 gcgtgcccac ccggttgctg cgcaaggacg ggccgctgac gcccgaggag cgccgggtga
     6061 tcgagctgca ccccgagtac gggcacgaga tggtgcgcgg catccgcttc ctgggggagg
     6121 cccgggccgc cgtcctccac caccacgaac gactggacgg cagcggctac ccctacggcc
     6181 tcaccggcga ccgcatcccg gaatcggccc gggtggtggc cgtcgccgac gccttcgacg
     6241 cgatgacgtc cacgcgctcc taccgcaggg cccggcccgt cgcggcggcc gtggcggagc
     6301 tccagcggtg tgccggggcc cagttcgacc cgcggatggt cggggcgctg gtccgggcgc
     6361 tgggccgcca cggctggcgc ccggccgtga cggcggacgg cacgccggcc ggccccgcgg
     6421 acgtgatccc gggcagccgg ggcgaagggg tgcgcgacgg cgtcggacgg ggggcgcggt
     6481 gacgggggag tcgggacggg gcaccggcgg cgggggcagg gcgtgacggc gtcaccgtac
     6541 gggcccctgt ccgcgtaccg gccccggccg ccggcggcgc acaccctggt cccggtgtgc
     6601 gccgggcttg tcgcgctcgc ctcgctcgcg tccgtcctgt ggtcgggacc ggtggaccgg
     6661 cccgtcgcgc tggccttcgg cgttctcgtc gtcctcggtg agctgacccg ggggaccggg
     6721 gccggggccc gggaggccgc gccgctcgga gccgccggag cgatggcgta cgcgctgctc
     6781 ggagaggtcg ccgggcggcc catgcagcac ggcgccggcc agaccgtcgc cgtcgtgctc
     6841 gccgcctcgc tgctcggcag cgtcccccgc atcgcacgcg gcggcggacc cgtgctggac
     6901 cctctggcgc gacgcgtgct caccgtcgcc ttcgccgccg tgtgcttccg gccgctccac
     6961 aaccagggcg tcttccacga ctggagcggt cccgcccacg tgctgctgct cgtcgcgctg
     7021 ctggccctga ccgcgctgtg cgaggccctg ctcgccgcgg ccccggcgca cgcgcggacc
     7081 gggtggccct tcggcccgct gctgcgcgag gagctgcgcg gcatggtcgg catcacgtcc
     7141 gcggtgtgcg cgaccggggc ggtgatggcg ctcgcggtgg ccgtcgcggg actgtgggcg
     7201 ctccccgtcc tctgcgttcc gctgctcctc acccacctgt cctatcggcg gtacgcggcc
     7261 gtgcgggcca cctaccggca gaccatcgcc tccctggccc gggccaccga gatcgccggg
     7321 tacaccccgg ccgggcacgc ccgccgcgtc gccgagctca gcggcgccgt cgggcgcgac
     7381 ctggggctct ccggtgccga tctgaccgtg ctggagtacg cggccctcat gcacgacatc
     7441 ggccagctga gcctcgtcga cccggtgccg gccggagcca ccgcctgcct gccccgcgcg
     7501 gagcagcggc gcatcgccct gctcggcggg gccgtcgtcc gccagaccgg ggtcgacgcg
     7561 gcggtggcgg tggtggtgga gcgccaggcc gacccctgcc gggagcagcc ggtcgccgcg
     7621 cggatcgtgc gggccgtcaa cgcgtacgag gagaaggcac gggacgccgg tcccggcggc
     7681 ggcctcaaag cgctggagga gctgcgcctg gccgtcgcgg acgactacgc tcccgacgtc
     7741 gtggaggcgc tggcccgggt gctctcccgg cagggaggga cgacgcgtga gcggcttcgt
     7801 cgagggcagg gacgggacga ggacgggcag tcttaccggg cccgctactg ggtaacccat
     7861 gggtaatgag cgacctcgtg gccgtacgtg gttggatgcg aaggagaagg tgtccggggg
     7921 cgcgggaagg cacagccagc ccacagaacg gaactggcag gcgggaatcg tgaggatctt
     7981 cggcaaggga cggcaccggc cctccgcctc ctggcggcag gccaccgacc gggcgttcac
     8041 actgatcggc gacggccggt acgaggatgc cggcgcgctg ctcacgcgcg ccgccgacct
     8101 ggaaccctgg ctgtcggagt cctggttcaa cctcgccctg ctgcacaagt tccggcacga
     8161 ctgggagcag gccagggcgg ccggcctgcg ggccgtggcg ctgctcgacc gggacatcgg
     8221 cgcgcccgac tggtggaacg tcggcatcgc ggcgaccgcc ctgcaggact ggccgctggc
     8281 ccgccgggcc tggcaggcct acgggctgcg caccccgggg aacgcgacgg acgcgggcga
     8341 gccgctcggc atggagctcg gcagcgctgc cgtacggctg tccccggagg gcgaggccga
     8401 ggtcgtctgg ggacggcggc tggaccccgc ccgcatcgag gtgctgtcca tcccgctgcc
     8461 ctcctccggc cggcgctggg gtgaggtcgt cctccacgac ggggtgccgc acggggaacg
     8521 caccaccacc gccgggcacg cctacccggt cttcgacgag atcgagctgt gggcgccgtc
     8581 gcccgtgccg acctgggtcg tcctcctgga ggccgccacc gaggcagacc gtgacgccct
     8641 ggagcagctc gccgccgacg ccgggttcgc cgccgaggac tggtcgtcgt cggtccggct
     8701 gctgtgccgg atgtgctcgg agtcgcggat gccgtccgac gagggcgagg gcgagcacct
     8761 cgacccgcac gaccacagcg aaccgggaca tcccgggcct ctcggccacc gcaccgacgg
     8821 gcagctgtgg gtgcccgagc gggagtgcgg ggtcgcggcg ccggccgccc tggtgagggg
     8881 gctgctggac gggtgggtcg cggacagccc ggactcgcgc gactggcggg acctggaaga
     8941 ggtctgctga gggcgtccct tcgccgtccg tcccgcgtgg ccggccgcgc ccacgcggcg
     9001 gagccgcaca ccgacacggt cccgcgcccc cgcggagcgc gatccccgta ccctgtatca
     9061 ggcatcaccc ccggttttat ccaggaaggc acacgtcggt catggcgcag caggacaccg
     9121 atcagcagca cgcgggcgtg ctccccgtgg acgacgacgg gttcgtcgtc gacaccgagg
     9181 agtgcgagga gcgcgagacg gcctggcggg agcgcggcac ctcgcgtccg atcacggtgg
     9241 tcggcaaccc ggtgctgcac aaggagtgcg aggacgtcac cgacttcggc gaggagttcc
     9301 agcagctggt cgcggacatg ttcgccagcc agcgcaccgc cgagggcgtc ggcctcgccg
     9361 ccaaccagat cggcgtcgcc aagaaggtct tcgtctacga ctgccccgac gacgagggcg
     9421 tgcgccacgt cggcgtggtc tgcaacccgc ggctcgtcga actgcccgcc gaccggcgcc
     9481 ggctggacga cagcaacgag ggctgcctgt ccgtgcccac cgcctacgcg ccgctcgccc
     9541 gccccgacta cgccgaggtg accgggcagg acgagcaggg caacccggtc aaggtgcgcg
     9601 gcaccggcta cttcgcacgg tgtttgcagc acgagacgga ccacctgtac gggtacctct
     9661 acatcgaccg gctctccaag cgtgaacgca aggaagcgct gcggcagatg gccgagaacg
     9721 agccgcgcta ccccgtggtc gcgaacgact gacaccgccc caccggtcat ccgtcttccg
     9781 tacgtacggc gcctgttcgg gactccccga gcgggcgccg tacgtctgtc ggaacctgcc
     9841 acacaacagg aggattccgg caccgggggg tagtgaatgg agcaaatccg ttcccatagc
     9901 ggtcagttgt ggtgctgaat aggaagcgcg gggatacgca acggcgcacg ccccgctcag
     9961 cgcgaggggt gcgccaccgg cggctgagag gggtttgttc gtgcatgctt tcccacacgg
    10021 caccacagcg gcaccgaccg cgatcgcagt accgccatcg ctccgccttc cggtgatcga
    10081 agcggctttt ccccggcggc tgcacccgta ttggccgagg ctccaggaga agacccgtac
    10141 ctggctgctc gaaaaacggc tcatgccggc ggacaaggtc gcggaatatg ccgacggtct
    10201 gtgctacacg gacctcatgg ccgggtacta cctgggtgcg cccgacgagg tcctgcaggc
    10261 gatagcggac ttcagcgcct ggttcttcgt ctgggacgac cggcacgacc gcgacatcgt
    10321 ccacgaccgc cccggcgcct ggcggcgcct gcggaaccag ctgcacgcgg cactcgactc
    10381 tcccggcgac cacctgcacc acgaggacac cctggtcgcc ggattcgccg acagtgtgcg
    10441 gcggttgtac gccttcctgc cgccgccggc gcagtggaac gcccggttca cccggcactt
    10501 ccacgcggtg atcgaggcgt acgaccggga attccacaac cggacccgcg ggatcgtgcc
    10561 cggtgtggcg gagtacctcg aactgcgccg gctcaccttc gcccactgga tctggaccga
    10621 tctgctggag ccgagcgcgg gctgcgaact tccggacgcc gttcggaaac acccggccta
    10681 cagtcgcgcg gcgttgttga gtcaggaatt cgccgcctgg tacaacgacc tctgctcact
    10741 gccgaaggaa atagcgggcg acgaggtgca caatctcggt atcagcctca tcacccatca
    10801 cggactgacc ctggaggaat ccatcggaga agtccggcga cgcgtggagg aatgcatcac
    10861 cgaattcctc gacgtggaac aggacgcaat gcggttcgcc gacgaactcg acgacggaac
    10921 cgtgcgcggg aaggaactga gcggtgccgt gcgggccggc gtcggcaata tgcggaactg
    10981 gttcagctcc gtctactggt tccaccacga gtccggtcgg tacatggtcg acaactggga
    11041 cgaccggtcc acgcccccgt acgtcaacaa cgaagcggca ggtgagaaat gaccgtccag
    11101 tcctcccccg agtccccggc ttcggccgga caaagcgcga ccgcgtcccc cgcggtccgg
    11161 gacgaagcga caccggagct gcgccggccg cccgttgcgg gcggcggcgt ccccctcctc
    11221 ggccacggct ggaggctggc ccgcgacccg ctggccttca tgtcccagct gcgcgaccac
    11281 ggcgacatcg tgcggatcaa gctcggcccg aagaccgtct acgcggtcac cgcaccggaa
    11341 ctcacgggcg ccctggccct gagccccgac taccacatag ccggtccgct ctgggagtcc
    11401 ctggagggcc tgctcggcaa ggagggcgtg gccaccgcca acggcccgct ccaccgccgg
    11461 cagcggcgca ccatgcagcc ggccttccgg ctcgacgcca tccccgccta cgggccgatc
    11521 atggaggagg aggcgcacgc cctcgccgag cgctggcagc cggggcggac cgtcgacgcc
    11581 acctccgagt ccttccgcgt cgccgtgcgc gtcgcggccc gctgcctgct gcgcggccag
    11641 tacatggacg agcgggccga gcggctgtgc gtcgcgctcg ccaccgtctt ccggggcatg
    11701 taccggcgga tggtcgtccc gctgggccct ctctaccggc tgccgcttcc ggccaatcgc
    11761 gaattcaaca acgcgctggc cgatttgcac ctcctggtcg acgagatcat cgccgagcgc
    11821 cgcgcatccg gtcaaaagcc ggacgatttg ctgacggcgt tgctggaggc gaaggacgac
    11881 aatggggacc cgatcgggga acaggagatc cacgaccagg tggtcgcgat actcaccccc
    11941 ggcagtgaaa ccatcgcctc cacgatcatg tggttgctgc aggcacttgc cgaccacccg
    12001 gaacatgccg accgcataca cgacgaagtc cgggcggtca ccggaggacg tcccgtcgca
    12061 ttcgaggacg tccgcaagct cacccacacg aacaatgtca tcgtggaagc catgcgtttg
    12121 cgtcccgccg tgtgggtatt gacgcgtcgc acggtggtcg agaccgaact cggtggctat
    12181 cgcattccgg ccggatcgga catcatctac agtccgtacg caatccagcg cgatgcgaag
    12241 tcgtacgccg acaacctgcg gttcgacccg gaccgatgga ttccggaacg tgcgacggat
    12301 gtgccgaaat acgccatgaa gccgttcagt gtcggcaatc ggaagtgccc tagcgaccac
    12361 ttctcgatgg ctcagctgac cctgatcacg gcggccctcg cctcgaagta ccgcttcgag
    12421 caggtggccg gctccaacga cgcggtccgc gtgggcatca ccctccgtcc gcacgatctg
    12481 ctggtcaggc cggtggcgcg gtgacgctca ggccgccgcc tccgggccgc ggaaggtacg
    12541 ccggtaggcg tgcggtgtgg tgtccagggc cctgacgaac tggtgcctga gggccgccgc
    12601 cgtaccgaat ccggtgcgcc acgcgatcgc gtccatcgtc tcgtccgtcg cctccagcag
    12661 ccgctgggcc agcagcacgc gctggcgcag tatccagcgg tagggagtcg tccccgtctc
    12721 ctgctggaag cggcgggcga aggtgcgcgg ggacatgcgc gcccgcgccg ccagctggtc
    12781 gacggtcacc tcctcgtcga ggtgctgctc catccaggac agcacctcgc cgacggtgtc
    12841 gcaggaggag cgcggcagcg gccgttcgat gtactgggcc tgaccaccgt cccggtgcgg
    12901 cggcacgacc atgcgccggg cgatcttgtt ggcgacctcc gtcccctgtt ccttgcggac
    12961 gatgtgcaga caggcgtcga tgcctgcggc ggtgccggca ctggtgatca ccgggtcctc
    13021 gtccacgtag agcacgtcgg gagccacgga gacccgtggg tactgccggg ccagctcggc
    13081 cgcgtggtgc cagtgcaccg cgcaccgccg cccgtccagc aggccggcgg cgcccagcac
    13141 gaacaccccg gagcacacgc tcagcacccg cgcgccccgc tccaccgccc gccgcagggc
    13201 gtccagcagc tccggcgggt actcccggcg ggcgaagtcg ctccccgccg gcacggtgat
    13261 caggtcggcc tcctccagcc gctccagccc gtacggcgtg gagacggtca gtccgccgac
    13321 atgggtggtc agctcgggac cctccgcgga gaccaccgcg aagtcgtacc gcggcaggcc
    13381 ctcgtcgctg cggtcgacgc cgaagacctc gcagacgaca ccgagttcga aaggatgcgc
    13441 accgtccagc aggacggccg ccacgttctg cagcatgccg acagtgtgcc tcggaagtgg
    13501 caggaaatcg aggccctgcg gcagtcctgc cactcccggt aaggagtccg gagcgcgaca
    13561 gtagtgtcat gaccggaaac cagatggaag ccctgatcgg aatgctcgtg accttcggac
    13621 tcctggtcct catggtcctc ccctcggcga tcggcatcgt gcgcgagagg cgcatcgacc
    13681 gtcagctcag ggaggcccgg gagaaccggc gggaggggga gaggcctcgc ccgactcaga
    13741 agtcctcgga caggtcgacg gtgccctcca ccgcgacctg gtacgccgag ggccgccgct
    13801 cgaagaagtt ggtcagctcc tgaaccccct gcagctccat gaaggagaag gggttctcgg
    13861 agccgtacac cggggcgaag ccgagccgcg tcagacgctg gtcggcgacg cactccaggt
    13921 actcccgcat cgagtcggtg ttcatccccg ggaggccgtc accgcacagg tcgcgcgcga
    13981 actgcagctc ggcctcgacg gcctcccgca gcatgtcggt gacctcctgc cggagctggt
    14041 cgtcgaacag ctccggctcc tccttgcgca cggtgtccac gacgtcgaag gcgaaggaca
    14101 tgtgcatggt ctcgtcccgg aacacccagt tggtgccggt ggccaggccg tgcagcagac
    14161 cacggctgcg gaaccagtag acgtaggcga aggcgccgta gaagaacagg ccctcgatgc
    14221 atgcggcgaa gcagatgagg ttgagcagga aacggcggcg gtccgcccgg gtctccagcc
    14281 ggtcgatcga ctcgaccgag tccatccacc tgaagcagaa ctcggccttc tcgcggatgg
    14341 aggggatgtt ctccacggcc gcgaaggcgg cggcccggtc gtccgggtcg ggcaggtagg
    14401 tgtccaggag cgtcaggtag aactggacgt gcacggcctc ctcgaagagc tggcgggaca
    14461 ggtacagccg cgcctcgggg gagttgatgt gcttgtagag ggtgagcacc aggttgttcg
    14521 ccacgatcga gtcgccggtg gcgaagaagg ccaccagccg tccgatcagg tgctgctcca
    14581 tggggctgag cttcgccagg tcggtgacgt ccgagtggag gtcgacctcc tcgacgtgcc
    14641 aggtgttctt gatggcgtcc cggtagcgct cgtagaagtc cgggtagcgc atggggcgca
    14701 gggtcagttc gaagcccggg tcgagcaggt tcttggtgtt catcactggc aggcctcgca
    14761 ggactcgggg ttttccaggg agcaggcgac cgcttcgggg tcgggggcct gctgtgcggg
    14821 gacggtggcc cgggcggcgg cgcgggcgat gcgggtcgcc gggcgggagc gcaggtagta
    14881 cgtggtcttc aggccctgct tccaggcgta cgcgtacatc gaggagagct tcccgatggt
    14941 cggcgtctcc aggaacaggt tcagcgactg ggcctggtcg aggtacgggg tgcgggcggc
    15001 ggccatgtcg atcaggccgc gctgcgggat ctcccaggcg gtgcggtaca gggcgcggac
    15061 gtcctcgggg atccaggaga agccctgcac cgagccgttg gcctcgcgca gcgcctcgcg
    15121 ggtgcgggcg tcccacacgc cgagccgctt gaggtcgtcc accaggtacg agttgacctg
    15181 gaggaactcg ccggagagcg tctcgcgctt gaagaggttg gacacctgcg gctcgatgca
    15241 ctcgtaggcg cccacgatcg aggcgatggt ggcggtcggc gcgatcgcca ggagcaggga
    15301 gttgcgcagt ccggtggtcg ccatgcgctc gcgcagtgcc gcccagcgct ccggccaggt
    15361 ggtctcgacc ccgtagtggt cggggtgcag cacgccccgg gccgtccggg tcttctccca
    15421 ggccggcagc gggccgttgc gctcggcgag gtcggtggag gtctcgtagg ccgcgagcat
    15481 gatccgctcg gcgatgcggg tggagagcgc cttcgcctcg ggggagtcga agggcaggcg
    15541 cagctggaag aagacgtcct gcaggcccat cgcgccgagg ccgaccggtc gccagcgggc
    15601 gttggagcgg cccgcctgct cggtcgggta gaagttgatg tcgacgaccc ggtccaggaa
    15661 ggtgacggcg gtgcggacgg tggcgtccag ccgctcccag tcgaggtcgc ccgcggcgac
    15721 gtcgacgaac gcgccgaggt tgaccgagcc caggttgcag accgccgtct ccccgtcgtc
    15781 ggtgacctcc aggatctccg tgcagaggtt ggaggagtgg accacgtggc ccggctcggc
    15841 ggtctggttg gcggtgcggt tggcggtgtc cttgaaggtc atccagccgt tgccggtctg
    15901 cgcgagggtg cgcatcatgc gtccgtacag ctcgcgggcg gggagggtcc tgcgggccag
    15961 tccggccgcc tccgcctcgc ggtacgcggc gtcgaactcc gcgccccaca ggtcgaccag
    16021 ctcgggcacg tcggcgggcg agaacaggga ccactgcccg tcggcgtcca cccggcgcat
    16081 gaactcgtcc ggcacccagt gggcgaggtt caggttgtgg gtgcggcggg cgtcctcgcc
    16141 ggtgttgtcc cgcagctcca ggaactcctc gatgtcggcg tgccaggtct ccaggtagac
    16201 cgccgccgca cccttgcgcc ggccgccctg gttcacggcg gcgaccgagg cgtccagcgt
    16261 cttcaggaac gggacgatgc cgttggagtg gccgttggtg ccgcggatca gggagccgcg
    16321 ggagcggatg cgggagtagg cgatgccgat gccgccggcg tgcttggaga ggcgggccac
    16381 ctggtggagg cggtcgtaga gggagtccag ctcgtccttg ggggagtcga ggaggtagca
    16441 ggacgacatc tgggcgtgcc gggtgccgga gttgaagagg gtgggggagg agggcaggta
    16501 gtcgaggcgg ctcatcagcc cgtagagggc ggccacctcg tcggccgcgc gggcggtgtc
    16561 gtcctcggcg agcccggcgg cgacacgcag catgaagtac tggggcgtct cgaccacctt
    16621 gcgggtgatc gggtgccgga gcaggtagcg gctgtgcagg gtgcgcagcc cgaagtagcc
    16681 gaagcggtcg tcggcggccg ggtcgatcag cgcgtccagg cggtccgcgt gcagccgtac
    16741 gaacgcggcc gtgcggtcgg cgatcagccc ctcgcggtgg ccggtggcga ccgactcggt
    16801 gaaggaggcg accccctggg aggcggcctc ggcgcggatg ccgatggtca gcagacgggc
    16861 ggccagcctg gagtagacgg ggtcctccga gatgagcccg gccgccgcct cggtggcgag
    16921 ctcgcgcagc tccgcctcgt ccgcgcgggc ggaccggccg cgcagcgcgg cggcggcgac
    16981 ccggccgggg tcggcgcccg ggaggtcggc ggtcagcacg gtcagggtcc gcagcagcgc
    17041 ggcaccgggg ccgtccggtt ccccggtcgc cgtcaccggg gtcgctgaag ccggatcggc
    17101 tggcgcgatg gtcacgtgga gcactccctc gctcggcacg gggcctggcg gagggcagga
    17161 ggaatcacga gcgcacacgg cgtcgcgtcc accggcccac tccacgaggc ccggacgtca
    17221 tggcacccgg gccaaggcgg ccgggcgcac tgtcggcagg tcctcggact caagcccgtg
    17281 cgcggacacg tggagacgcg aacacgcaca agtacaccgt tgcgggacag ttccggattc
    17341 gcaccggatt cccctgcggc gacagcgagc acgagcatac atcttgtgcc gggcaccgcc
    17401 agcaccccca gatgttgtgt ccgtgagcgt gtcgggaggg tgtcagagcg tcagttcata
    17461 ggtgagcagg gtgaagtcgt ccagcttcgg cagggggttc cagtcgcgct ccggggtgcg
    17521 ggtgaaaccc aggcgcgcgt agaggcggtg ggcgccgtgc atggtgcgct gggtggacag
    17581 cacgacccgc gcgcagcccg gcacggaccg ggcgcggtcg acgcaggccc gcaccagcgc
    17641 ctcgccggcg ccgcgtccgc gcgcctcgcg ggcgacggcg agcatgcgta tctcggcctc
    17701 gccgggacgg gcgatgtcgg ccatcgggcc accgcggggc acgaaggtga cgccaccgag
    17761 cacaccgccg tccgatgcgg cgaccagcac ctcggcggcg gccgcccgtc gggccacggc
    17821 gcgcagctcg tggaggtagg cgtcgtcctc cccgaagtcg aggaggccgt cgcccaggta
    17881 ggcgcgcgcg gtgatctcac cgagggtgtc gtactcctcg gccgtggcac gccggatcac
    17941 gaagtccatg cccccgagtg tgcccgacgg gtacgacagc gggccgccgg atttctccga
    18001 cggcccgcct gagggagggg gtcagtgcga ggtgcccgcc gtggccggcg gcagctccac
    18061 ctcgacgccc gggtcgcccg cgtccgcggt gtagtcgccg ggcttggtct cgtcgatgcc
    18121 ctcgggcgcc ttgagcgccc tcatgacgaa ggtcaggacc acggtgacca gcacgttcag
    18181 cacgaaggcg gtgaggccga tgtagccgat ctcaccgatg ccggggatct cgtccgagga
    18241 gccgccgaag tgcttctgcg tcggcgaggc caccccgtac gcggcgaccg tgccgtagac
    18301 catgccgacc gcccagccgc cgagcagggc ccagcggtgg aaccagcggg tgaacaggcc
    18361 gcccaccagg gccgggaagg tctgcaggat ccagatgccg ccgagcagct ggaagttgat
    18421 ggcgaccgtc ttgtccatgc cgaggacgaa gaccagcgcg cccaccttca ccagcaggga
    18481 caccagcttg gagaccttcg tctcctgggc cggggtggcg tccggcttga tgaagtcctt
    18541 gtagatgttg cgggtgaaga ggttggccgc cgcgatcgac atgatcgccg ccggaaccag
    18601 ggcgccgatg ccgatcgccg cgaaggccac accggcgaac cagtccggga acatgttctc
    18661 gaagagctgg gggatcgcca gctgcccgtt ctccaccttc accccggccg cgatcgccat
    18721 gaagccgagc agcgcgagca ggcccagcat cagcgagtac agcggcagga tcgtggtgtt
    18781 gcggcggatc acctcacggc tgcgcgagga cagcgtcgcg gtgatcgagt gcgggtacat
    18841 gaagagcgcg agcgccgaac ccagcgccag cgtggcgtac gtccactggc cgccgtggtc
    18901 cggcgtcagc gagcccttgc ccgactcggt gaacttgtcg cccgccgccg cgaagatgtc
    18961 gtcgaaaccg ccgagcttga tcgggatgta gatgatcgcc accgcgatga cgatgtagat
    19021 cagcgtgtcc ttcacgaagg cgatcagcgc gggcgcgcgc agtcccgacg agtaggtgta
    19081 cgccgccagc acgccgaagg cgatcagcag gggcaggtcc ttgacgaacc agttggtgtc
    19141 ctcgccgccg ccgaggccca tcacgtccag gacggcctgg atgccgacca gctggagcgc
    19201 gatgtacggc atggtggcga ggatgccggt cacggccacc gccagcgaca gccccttcga
    19261 gccgaaccgg ccgcgcacga agtccgaggt cgtcacgtag ccgtgcttgt gggagaccga
    19321 ccacagccgg ggcaggaagg tgaagatcag cgggtagacc aggatcgtgt acggcaccgc
    19381 gaagaagccg gaggcgccgg ccgcgtagat cgccgccggg acggccacga aggtgtacgc
    19441 cgtgtacagg tcgccgccca gcaggaacca ggtgacccag gtgccgaacg agcggccgcc
    19501 gaggccccac tcgtcgaggc tgtgctcgtt ctcggccctg cgccagcggg cggccaggaa
    19561 gcccatggcg gtgacgagca ggaagaagaa gatgaagacg gcgagtgcga cgccgttcac
    19621 gccgtcgttc acttggcccc gccttcccga cgggcgcgct ggtcacgctg ccacagcttg
    19681 taggcgatca tcgtcagcgc ggtggagatg agcacccacg ccatctggta ccagtagaag
    19741 aacgggatgc cgatgaaggc cgggtccgtc ttcgcgtagg aaccgaccca gagcatggcg
    19801 acgaacggtg cgacaaggca gaggccgatg acgacgcgca ccggcgtcac caccggccct
    19861 ctgctcactt ctggggcttg tgacatacgg cggctccgtc ccctcgctga tcacctcgtg
    19921 cagtgcgcac gaaatgtagg tgacggcgtc gagagagcgg aacccctcgt ccgtatatcg
    19981 gtcctgaact gcaacttcac ggtcccgggt gccggaatat gtcggacacg cgcgccgcgg
    20041 ggcaggcggg aacggccgga cgggccctag tcctggggcc gcttcagccg ggccacgaac
    20101 ttgtagcggt cgccccggta caccgagcgc acccactcca cgggctggcc cgtgcggtcc
    20161 tgcgagtgcc gggagagcat cagcatgggc aggccgacgt cggtgccgag cagaccggcc
    20221 tcgcgcgggg tggccagcga ggtctcgatg gtctcctcgg cctcggcgag atggacgtcg
    20281 tagacctcgg cgagcgccgt gtagagggac gtgtacttca ccagggacct gcgcagcgcc
    20341 gggaagcgct tggccgacag gtgggtggtc tcgatcgcca tgggctcgcc gttggccatg
    20401 cgcagccgct cgatgcgcag tacccgcccg ccggccgtga tgtccagcag cccggcgagc
    20461 cggtcgtcgg cggtgatgta gccgatgtcc agcagctgcg aggtgggttc gaggccctgc
    20521 gcccgcatgt cctcggtgta cgaggtgagt tgcagggcct gcgagacctt gggcttggcg
    20581 acgaaggtgc ccttgccctg gatgcgctcc aggcgcccct cgacgaccag ttcctgcaag
    20641 gcctggcgca ccgtcgtgcg cgaggtgtcg aactccgcgg ccagggtgcg ctcagggggg
    20701 accggagtgc ccggtgcctg cgtccgggtc atgtcgagca ggtgcttctt cagtcggtag
    20761 tacttgggca cgcgcgcggt acggacggtc gccccaccct cgttctccgc actgctgacg
    20821 tcggtgctca tgctctgcct tcccggctcc gggtgccgaa gcgaccgata tccctgtcgg
    20881 ccacggccca catcgtggca cggctccggg cgggatggcc ccgcacgctc cgtgatccct
    20941 tctgtatacc tccgacaccc ctgttggtct agtccacagc gccgtcggac accgctggta
    21001 cgcgcgttcg gaaccgtatc gagacgcctt tcggcggacg gtggtacacc ccctcccggt
    21061 ccgcccgatc tgccgcttgc gcaatgaaag gt
//
