LOCUS       NZ_CP012382            21014 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4172600
            Orig. end                         :: 4193614
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21014
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="furan"
                     /region_number="11"
                     /rules="(mmyO or AvrD)"
                     /tool="antismash"
     cand_cluster    1..21014
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(mmyO or AvrD)"
                     /kind="single"
                     /product="furan"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21014
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11014](-)"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11014)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
     gene            84..332
                     /locus_tag="SAM23877_RS37545"
                     /old_locus_tag="SAM23877_3919"
     CDS             84..332
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024988.4"
                     /locus_tag="SAM23877_RS37545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3919"
                     /product="transcriptional regulator"
                     /protein_id="WP_079030293.1"
                     /transl_table=11
                     /translation="MGEAEFGLVQKQLDLSASVVSKHVTVLTDAGYVEHRKAVRDTRQR
                     VWLRLTRRGRDACRGHALAALRRFRSGRGRSPPRRGR"
     gene            complement(289..855)
                     /locus_tag="SAM23877_RS18605"
                     /old_locus_tag="SAM23877_3920"
     CDS             complement(289..855)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550378.1"
                     /locus_tag="SAM23877_RS18605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3920"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_053134331.1"
                     /transl_table=11
                     /translation="MTAEMVAPAWMHEQITAEEYESWSEEQCAGIEIVDGMVVVSPSAS
                     KRHNRLARLLANALDAAAGPDWNADTDFDVRLQDVPLTNRRPDVIVYRADTIDITPTRP
                     EHVLLVAEVVSPGSETTDRIVKVDQYARAGIGFYWRIEQAATGTPLVYTYLLDPATRTY
                     REGDVFAGTLKITAPFAAEIDLGRI"
     gene            1057..2496
                     /locus_tag="SAM23877_RS18610"
                     /old_locus_tag="SAM23877_3921"
     CDS             1057..2496
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324846.1"
                     /locus_tag="SAM23877_RS18610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3921"
                     /product="MFS transporter"
                     /protein_id="WP_063482580.1"
                     /transl_table=11
                     /translation="MTTADTSTSAAAAHPIPVRMTGRQVAALVVLLASQFMMAADFSVL
                     NVALPEVGTALGFSTGSLQWISTTFALCAAGCTLVFGRVGDYVGRRRIFTAGMAVLAVS
                     SLVGGIAESPAMLLTARTLQGLATAAVTPAALALLTTAFTEPSLRTRALGLNSVMMSSG
                     FSVGAILGGFLTDVFSWRWAFFINIPVAVAAILIVPLVVDESRAEKRSRIDLPGAVLIT
                     LGLFSAIYGVTRVGEDGFDLVAGASLVAAAVLLGVFWAVQSRTVDALVPVRVLKKPDIA
                     FGNLAALFIFGGETALIFFTGLYVQDVLGLSSLAAGLVLLGIGVGQIIAGTVGPRILQR
                     VPPRTLLGVSLFLQGAFMLPALWATSDTRWLIPLIATQFVNAFFSMTAALSFMVIATSS
                     VDSDMQGMATGMATQSQQVGIAIGIPLISAVFAAVIGHGTVTAAEELSGIHTAIGVAGG
                     CQVVVGLLLWAVLRRKTALPG"
     gene            2626..3486
                     /locus_tag="SAM23877_RS18615"
                     /old_locus_tag="SAM23877_3922"
     CDS             2626..3486
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324847.1"
                     /locus_tag="SAM23877_RS18615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3922"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_053134337.1"
                     /transl_table=11
                     /translation="MEHIVNTDLGSYLRQMRERVRPEQMGLRSSGSRRVPGLRREEVAA
                     LAGVSQTYYTRLEQSQTAHASPQVLLSIARALQLSPDEQDYLLKIGTPVQNPHAPAPCG
                     DQVSPYTRMLVESLGNVAAAVLNYRCDILSWNSLYHRLFAPHIDFEAPERAEQRPNIIK
                     MNFLDDEVRSLYADWAAESESNVTYLRFISADHRHDPQLAELIGELTIQSEEFAELWCR
                     QRVSNCIEGTKLFDHPVVGELELMYQSADLQDGNILKFYHADPDSPHEAALRLLTVDLD
                     SVHHR"
     gene            complement(3553..4509)
                     /locus_tag="SAM23877_RS18620"
                     /old_locus_tag="SAM23877_3923"
     CDS             complement(3553..4509)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020130.4"
                     /locus_tag="SAM23877_RS18620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3923"
                     /product="ketoacyl-ACP synthase III family protein"
                     /protein_id="WP_148663818.1"
                     /sec_met_domain="fabH (E-value: 4.9e-22, bitscore: 77.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIADYALAMPSGKRSVDEVARESGYGLDKLGQVLPSGKFSVLAE
                     GETAWGLGRDAAARLLARSPVPLEEIGLVLYAGSSEWGTPFWSPAAKIAGELGITQAHC
                     YEVSNFCNAGMVAVKLADDQVRAGTHPYALVIIADRLSELVEYGTGYLELFNFADGAAA
                     VLLTADAAATRYEVLGGAHHTDPQWVDSYYGEIKDGRIKVERGGKQDGLGDAFLDNFTT
                     LTHRVLAGIGAGVAEVAHFLVTHGNQDTHRSYLAALGVDASRSVFQYERDGHLGGVDPL
                     QALEELEREDRIGPGDLVIVATAGSGFTWGVTALRRT"
     gene            complement(4528..5508)
                     /locus_tag="SAM23877_RS18625"
                     /old_locus_tag="SAM23877_3924"
     CDS             complement(4528..5508)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324849.1"
                     /locus_tag="SAM23877_RS18625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3924"
                     /product="aldo/keto reductase"
                     /protein_id="WP_053134343.1"
                     /transl_table=11
                     /translation="MQYVRLGSSGLKVSRLALGCMSYGEPGLGTHPWSLPEEESLPFLA
                     QALDLGITFFDTANIYSLGTSEEFLGRGLRKLTRREDVVIATKVYEKLDANPLSGGLSR
                     SAVMRELDASLRRLDTDYIDLYIVHRWDPHTPIEETMEALHDVVRAGKVRYLGASSMHT
                     WQFVKAQYVADLHGWTRFVSMQNHYNLINREEEREMLPYCLAEGVGVTPWSPLARGRLA
                     RDWETESARTAGDPVQDRFYAPTEEADRAVTRVVAQIAAERGVPMAQVALAWLLRQPAV
                     TAPVVGATKPHHLQDAVAALELELDDTEAARLAAPYVPHAVVEYV"
     gene            complement(5519..6073)
                     /locus_tag="SAM23877_RS18630"
                     /old_locus_tag="SAM23877_3925"
     CDS             complement(5519..6073)
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014664.4"
                     /locus_tag="SAM23877_RS18630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3925"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_053134345.1"
                     /transl_table=11
                     /translation="MTPRVTLTEVADMTPEQRSVYEKFESNLTRALLLTKNSAAAHLAL
                     GGTFTVGLLSLLDREVIVLRVAKLRDSEFERLLHYPLARKAGLDDTEIKAIEDALYDEL
                     PAERAALVRYVTDCMVDHKASEEAYWGLRTYYSENEIAEVTHLAGHSAMTAMYLASLDI
                     PLDEGIASWGRLTEVQDEVEG"
     gene            complement(6115..7677)
                     /locus_tag="SAM23877_RS18635"
                     /old_locus_tag="SAM23877_3926"
     CDS             complement(6115..7677)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="SAM23877_RS18635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3926"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_063796819.1"
                     /transl_table=11
                     /translation="MQRPRVLVVGAGPVGMVLAAELLAHGVRADVVSKLRRQSPHSRAT
                     ILWPRVLELLDRVGVGRKLVEGGHYFDQMNYYSNKKMVGLVRFDRLRGVGYPFAITIPQ
                     WRTEAILEEHLAGLGGAVDYDHTFLEGTRHPHGVDCRLRLPDGTEQSRTYDYVVGADGY
                     NSAVREAFGFRFAGRTLRTRLAITDAEILGETTSSEAAYYFTRTGNMVLAPLGDGVFRV
                     GASVPDGYHGDTPDRAFFETLLAERVPGARRLGEMRFSGVFTAHVRSASTYGSDRVFLV
                     GDAAHAMSPSGAQGLNTGIQDAVNLGWKLAGVVRGDYHPELLDSYDTERRPAVDRVAAL
                     STRLARIGLYSSRRRTLARDAVYRLGSATRALEKALAPRLAQIDTHYGARPRRSTLVPG
                     ERLPLGWRGSSTQPVLAVDRFTVLLWPGLRYRHEHWTRVVDAVRAETSGAALADLGGRP
                     PGPLLGRLPRAAHALLVRPDGHLDTLVPLDAHAPETCVRTVARALAHRVRDTAPAALTA
                     VPA"
     gene            complement(7693..7986)
                     /locus_tag="SAM23877_RS18640"
                     /old_locus_tag="SAM23877_3927"
     CDS             complement(7693..7986)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015925.4"
                     /locus_tag="SAM23877_RS18640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3927"
                     /product="putative quinol monooxygenase"
                     /protein_id="WP_053134350.1"
                     /transl_table=11
                     /translation="MSIEITVVFDVVPDRMDSVTAAFQELCDATREEEGALRFDAFRSE
                     EHRDVVVLVEDWADQEAIDLHMKEPYVADFLARTEGSFVRPPYVHRLRALGA"
     gene            complement(7983..8672)
                     /locus_tag="SAM23877_RS18645"
                     /old_locus_tag="SAM23877_3928"
     CDS             complement(7983..8672)
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012521.4"
                     /locus_tag="SAM23877_RS18645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3928"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_053134353.1"
                     /transl_table=11
                     /translation="MRVVLLRHAETDRNAADRFQGQADIPLNDEGVRQAQRAARSLPPG
                     DWAAVYSSPMARAAQTAAYAAGRLDVPHHRVDGLRERHLGGLDGLSRAEFARSRPATLR
                     RLLDDPGYAPPGGESGHAARTRFCAALHEVLAAERTAGQVLVVAHGGVLNLLARSLLAA
                     GDEPPRLMVGTCRALCLDAEWTARGRARVALRRWNADPRECAATGRPSPPVTFVDLVDH
                     AKEVTHT"
     gene            complement(8676..8936)
                     /locus_tag="SAM23877_RS18650"
                     /old_locus_tag="SAM23877_3929"
     CDS             complement(8676..8936)
                     /NRPS_PKS="Domain: PP-binding (8-73). E-value: 5e-12.
                     Score: 38.0. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS18650_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="SAM23877_RS18650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3929"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_053134356.1"
                     /sec_met_domain="PP-binding (E-value: 5.8e-08, bitscore:
                     31.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSVSTMIIEILTGKFEIPQEEVARSTVFEDLAVDSLALLEMSL
                     LLEKRLGVSIAEGVLTSQQSIDEAARAVEALGAPAAVGSAV"
     aSDomain        complement(8718..8912)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS18650_PP-binding.1"
                     /evalue="5.00E-12"
                     /label="SAM23877_RS18650_PP-binding.1"
                     /locus_tag="SAM23877_RS18650"
                     /protein_end="73"
                     /protein_start="8"
                     /score="38.0"
                     /tool="antismash"
                     /translation="IIEILTGKFEIPQEEVARSTVFEDLAVDSLALLEMSLLLEKRLGV
                     SIAEGVLTSQQSIDEAARAV"
     gene            complement(9003..10004)
                     /locus_tag="SAM23877_RS18655"
                     /old_locus_tag="SAM23877_3930"
     CDS             complement(9003..10004)
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324854.1"
                     /locus_tag="SAM23877_RS18655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3930"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_053134359.1"
                     /sec_met_domain="fabH (E-value: 6.5e-115, bitscore: 382.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRAAVLAGVGGYVPPRVVTNEELSRRLDTSDAWIRTRTGIAARH
                     VVDPGTSTGDLAVEAGGRALKNAGADGADLVIVATTTPDRPCPATAPAVAARLGLTGVP
                     AYDVAAVCSGFVYALQAGAAAVTAGFAERVLVVGAESFSTILDPADRTTSVIFGDGAGA
                     VLLRSGERTEPGAVLDVHLGSDGSMADLITVRGGGAEERSRGGVPRPEDRYFRMDGKSV
                     FFAAVRRMAESSRTALARTGWEVADVDRLVGHQANTRIIHAVAEQLGLPPERAVLNIER
                     VGNTSAASIPLALADGLADGTLTAGDRVLLTAFGGGATWGSATLVWPDLPIG"
     gene            complement(10001..11014)
                     /locus_tag="SAM23877_RS18660"
                     /old_locus_tag="SAM23877_3931"
     CDS             complement(10001..11014)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     AvrD"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039533.1"
                     /locus_tag="SAM23877_RS18660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3931"
                     /product="AvrD family protein"
                     /protein_id="WP_063796783.1"
                     /sec_met_domain="AvrD (E-value: 1.1e-103, bitscore: 345.8,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTSAPTVVASVDDHLGPAEQRFFGRGFRRVAYDIGELRLTRGA
                     DGTVRAASSVGVRYPADWSKKAAGTDLLPHFSTVDGLVVAAQLAEACLTGLVPDLRDGW
                     LRKVRITAGTSPQEDLARLPAEATLRRTDPLAGEPGRAVSLVDCAVGTMRTRCEVVHAL
                     PTGTVPASGPYAGLDALLGPAADRYFGTGFTTRRQLVRDVAVDHRALSAEAALTVVHED
                     GAVVPTAGLEGAHQPCVSMVDAFVTALQLAQIMLYDLDDMRRQDSNTLWMRQTTLTAAR
                     PDRPTTAVPVTTALDEPGLLRMGKGTWRTLDVVAELAGLRVRSAVAHRLPDGKVPA"
     gene            complement(11011..11490)
                     /locus_tag="SAM23877_RS18665"
                     /old_locus_tag="SAM23877_3932"
     CDS             complement(11011..11490)
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324856.1"
                     /locus_tag="SAM23877_RS18665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3932"
                     /product="hotdog fold thioesterase"
                     /protein_id="WP_235614699.1"
                     /transl_table=11
                     /translation="MLGPMRVDGAYEGEQLTRRMGIEIVTCEPGLVVGTMPISGNRQPV
                     GILHGGANAVLAETLGSLAAFLHAGPGGNAVGVDLSCTHHRWVSSGTVTGVCRPLGERQ
                     AMASYEIVITDDSGNRTCTARLTCAVRRGDRRGPGGRTAPRRRPAQDQPRRTEHR"
     misc_feature    complement(11625..11638)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.0"
                     /tool="antismash"
     misc_feature    11709..11722
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.03"
                     /tool="antismash"
     gene            11738..12715
                     /locus_tag="SAM23877_RS18670"
                     /old_locus_tag="SAM23877_3933"
     CDS             11738..12715
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073993.1"
                     /locus_tag="SAM23877_RS18670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3933"
                     /product="aldo/keto reductase"
                     /protein_id="WP_053134367.1"
                     /transl_table=11
                     /translation="MQRVSLGGLDVSGIGLGAMSMSDYYTGAGNDEEEAVRTIRRALDL
                     GVDLIDTAEIYGPFVNEELVGRAVAGRRDEVVIATKFGLVSHDGGGPNVLDSSPANVRK
                     AVEGSLRRLGTDHIDLYYQHRVDPDTPIEDTMGALAELVREGKVRHVGLSEAGPDTIRR
                     AHSVHPVTAVQTEYSLWSREPAETLLPLLRELGAGLVAYSPLGRGFLTGTIRSTREFAP
                     DDFRLSTPRFAEGNFERNLRIVDEVEDVARSVGATPAQVALAWLLAQGDGIVPVPGTRR
                     VTRVEENAAAAEVVLTSGQLARLDALTPPVGDRYAEQDLARTGL"
     gene            complement(12746..13438)
                     /locus_tag="SAM23877_RS18675"
                     /old_locus_tag="SAM23877_3934"
     CDS             complement(12746..13438)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="SAM23877_RS18675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3934"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_053134370.1"
                     /transl_table=11
                     /translation="MESQTLVRSDTTRTALQPLTDSDSVADQLDALHHRAVRELRLALP
                     RRPYDRRVRERAALLSGELVRRGARVRVLHPADVARDPAQAEDLRRIAASGAQVRGLPR
                     LPVWMAVVDRDLAIVPSDPALGESSATLLRGRSLVAGHQALFDQVWAGCAPVPTDSGAG
                     GPGRGGLDEREREALVLLAEGLTDEGISRRTGLSVRTVRRTIAGVMSRMGAQSRFQAGV
                     EAARRQWI"
     misc_feature    complement(13319..13321)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13433..13443
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     misc_feature    complement(13601..13617)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.57"
                     /tool="antismash"
     gene            complement(13693..14493)
                     /locus_tag="SAM23877_RS18680"
                     /old_locus_tag="SAM23877_3935"
     CDS             complement(13693..14493)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.4"
                     /locus_tag="SAM23877_RS18680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3935"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_053134373.1"
                     /transl_table=11
                     /translation="MTESRGSDIPEAAEFQLEFADLPHLLRAWRTEAGAKLGRGKALPQ
                     KEVAQRMGVSERWYRALESGAQVPLTLDTLTQLAEALDLGPDERTALYWYRLAEVSDEE
                     RTADDGGRLGRLKDLVDAQTTFPAYLIDHAWNIITYNALMARWFPWVREPEANLMRWVL
                     LNPESREQIVEWRKQAALYLAQLRFALFRSPDDPTLNDLLTSVQHEPVCRELWNAGPRI
                     IAFRQGGKFRLALPHVSQTELVVTAQVLLPAYRPGARFVALMPA"
     misc_feature    complement(13888..13890)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14649..14663)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.57"
                     /tool="antismash"
     misc_feature    complement(14650..14661)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            14663..15940
                     /locus_tag="SAM23877_RS18685"
                     /old_locus_tag="SAM23877_3936"
     CDS             14663..15940
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (80-422). E-value:
                     1.6e-53. Score: 174.0. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS18685_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379552.1"
                     /locus_tag="SAM23877_RS18685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3936"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_167355235.1"
                     /sec_met_domain="t2fas (E-value: 4.1e-140, bitscore: 465.9,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.6e-49, bitscore:
                     167.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVRYMSRRVVVTGLGTMSPLGAGTDSLWEGLLAGRCGIRPLTG
                     AEFAAHPVRIAGTVPVDPAGLLPPPRARRMNRGALLAVTAAREAWRDAGFCAGGTRDSG
                     LDPDRVGVSVGTIIGGAGVLVEGARRLRDRGARAVPPLTAPMTVPSQAASQISLDLCIT
                     GEARTVVSACASGTEAIGQAIDRIRYGHVDIALAGGAEAAVTPEVMAAFSAMRALSARN
                     DTPEAASRPFAKDREGFVNSEGAGLLVLESEEHALARGARIYCEAAGWGLSADAYHMAA
                     PDPTGGGVATALRRAVTDAGSRTADVVHINAHATGTVEGDLAEAAALSTVFGDADGAVP
                     VPVTALKGSLGHLQGAAGGVEAVATALTLHHGIIPPTTGCDDLDDAIPLDVVTNLARPL
                     PARGDLALSNSFGFGGHNAVLALRRR"
     aSDomain        14903..15928
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS18685_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.60E-53"
                     /label="SAM23877_RS18685_PKS_KS.1"
                     /locus_tag="SAM23877_RS18685"
                     /protein_end="422"
                     /protein_start="80"
                     /score="174.0"
                     /tool="antismash"
                     /translation="LAVTAAREAWRDAGFCAGGTRDSGLDPDRVGVSVGTIIGGAGVLV
                     EGARRLRDRGARAVPPLTAPMTVPSQAASQISLDLCITGEARTVVSACASGTEAIGQAI
                     DRIRYGHVDIALAGGAEAAVTPEVMAAFSAMRALSARNDTPEAASRPFAKDREGFVNSE
                     GAGLLVLESEEHALARGARIYCEAAGWGLSADAYHMAAPDPTGGGVATALRRAVTDAGS
                     RTADVVHINAHATGTVEGDLAEAAALSTVFGDADGAVPVPVTALKGSLGHLQGAAGGVE
                     AVATALTLHHGIIPPTTGCDDLDDAIPLDVVTNLARPLPARGDLALSNSFGFGGHNAVL
                     AL"
     misc_feature    complement(16375..16389)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            16722..16988
                     /locus_tag="SAM23877_RS18690"
                     /old_locus_tag="SAM23877_3937"
     CDS             16722..16988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015034585.1"
                     /locus_tag="SAM23877_RS18690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3937"
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_053134376.1"
                     /transl_table=11
                     /translation="MSMKRTNVYADPEDLAIIKEAAKRRGISEAEIIRQGIHLAAMANR
                     VWDEPLFSRTFEGTGRTPSKAEVRDAVADAVRREADSSSGTAA"
     gene            16985..17428
                     /locus_tag="SAM23877_RS18695"
                     /old_locus_tag="SAM23877_3938"
     CDS             16985..17428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999400.1"
                     /locus_tag="SAM23877_RS18695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3938"
                     /product="PIN domain-containing protein"
                     /protein_id="WP_053134378.1"
                     /transl_table=11
                     /translation="MIIVIADTSGLLAALDSAHPEHRAANEAIMAAGLLVMSPLLLAEL
                     DHVATRELGRAAALGAVDDLRRWMSRGRVVMPEITEGHLGAAQSVRVRYRALDLDLADA
                     VNVALAADYDTDAILTLDRRDFRAVRPLGHHKVFRVLPDDLPL"
     misc_feature    complement(17501..17517)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.74"
                     /tool="antismash"
     misc_feature    complement(17502..17516)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     tRNA            complement(17828..17901)
                     /anticodon=(pos:complement(4190467..4190469),aa:Gly,
                     seq:ccc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SAM23877_RS18700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAM23877_tRNA52"
                     /product="tRNA-Gly"
     gene            complement(17828..17901)
                     /locus_tag="SAM23877_RS18700"
                     /old_locus_tag="SAM23877_tRNA52"
     misc_feature    complement(17857..17871)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    complement(17876..17892)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.05"
                     /tool="antismash"
     gene            18412..18987
                     /gene="dcd"
                     /locus_tag="SAM23877_RS18705"
                     /old_locus_tag="SAM23877_3940"
     CDS             18412..18987
                     /EC_number="3.5.4.13"
                     /GO_function="GO:0008829 - dCTP deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009394 - 2'-deoxyribonucleotide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="dcd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948066.1"
                     /locus_tag="SAM23877_RS18705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3940"
                     /product="dCTP deaminase"
                     /protein_id="WP_053134381.1"
                     /transl_table=11
                     /translation="MLLSDKDIRAEIDAGRVRIDPYDDSMVQPSSIDVRLDRYFRVFEN
                     HRYPHIDPSVEQADLTRLVEPEGDEPFILHPGEFVLASTYEVVSLPDDLASRLEGKSSL
                     GRLGLVTHSTAGFIDPGFSGHVTLELSNLATLPIKLWPGMKIGQLCMFRLTSPAEHPYG
                     SERYGSRYQGQRGPTASRSFINFHRTQV"
     gene            19001..19498
                     /locus_tag="SAM23877_RS18710"
                     /old_locus_tag="SAM23877_3941"
     CDS             19001..19498
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240229.1"
                     /locus_tag="SAM23877_RS18710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3941"
                     /product="phosphoribosyltransferase"
                     /protein_id="WP_053134384.1"
                     /transl_table=11
                     /translation="MSDVRENLTYEQFGVAVRELAQAVADDGYEPDIVLSIARGGVFVA
                     GGLAYALDCKNIHLVNVEFYTGVGTTLEMPVMLAPVPNVIDFSRKKVLITDDVADTGKT
                     LKLVRDFCLDTVAEVRSAVIYEKSHSLVQCEYVWKRTDDWINFPWSVQPPVVRKDGQVL
                     DA"
     gene            complement(19603..20619)
                     /locus_tag="SAM23877_RS18715"
                     /old_locus_tag="SAM23877_3942"
     CDS             complement(19603..20619)
                     /GO_function="GO:0031267 - small GTPase binding [Evidence
                     IEA]"
                     /GO_process="GO:0006888 - endoplasmic reticulum to Golgi
                     vesicle-mediated transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029158.1"
                     /locus_tag="SAM23877_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_3942"
                     /product="Yip1 family protein"
                     /protein_id="WP_053134387.1"
                     /transl_table=11
                     /translation="MSQLGRKGRPERPRPARHSPGPGTFEGVAGFRIGRGRDNGAPHAR
                     PQRPPYGQQAPQGPSYGGPATPQQPYPQQPYGGGGPGPGAGGSPWPQPHGGGHGEPEYF
                     GDGGHPQGGPHGGQAPHDPYAANNPGHTQAFTVDDPYNQGETYRAGSAPPPGPVGPRLH
                     WKALLRGVVLAPGATFLQMRDYAMWAPALIVTFLYGLLAVFGFDGAREEAINATLSNAV
                     PIVLTTAVAMVLSAFVLGVVTHTLARQLGGDGAWQPTVGLSMLIMSLTDAPRLVVALFA
                     GGDAPFVQILGWATWVAAGALLTLMVGRSHDLPWPKALGASAIQLIALLSIVKLGTF"
     misc_feature    complement(20612..20627)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
ORIGIN
        1 gggcgacgac cgcgacggag ccgagccccc tcgggccgcc ggcctgaagt cacgaggggg
       61 cgctacgact ccggagagac gccgtgggcg aggcggagtt cggcctggta cagaagcaac
      121 tcgacctctc cgcctccgtg gtgagcaaac acgtcaccgt gctgacggac gccggctacg
      181 tcgagcaccg caaggccgtc cgcgacaccc ggcagcgagt gtggctccgg ctgacccggc
      241 gaggccggga cgcctgccgg gggcacgctc tggctgccct gcgacggttc agatccggcc
      301 gaggtcgatc tccgccgcga agggggcggt gatcttcagg gtgccggcga acacgtcccc
      361 ttcgcggtac gtcctcgtgg cgggatcgag caggtacgta tacaccagcg gggtgcccgt
      421 cgcggcctgc tcgatccgcc agtagaagcc gatcccggcc ctggcgtact ggtccacctt
      481 cacgatccgg tcggtggtct ccgagcccgg cgacaccacc tcggccacga gcagtacgtg
      541 ctccggacgg gtgggcgtga tgtcgatcgt gtccgcacgg tagacgatga cgtcggggcg
      601 gcgattggtc agcgggacgt cctgaagccg gacgtcgaaa tccgtgtcgg cgttccagtc
      661 gggaccggct gcggcgtcca gggcgttcgc caggagccgg gccagccggt tgtgccgctt
      721 ggaggcgctg gggctcacga cgaccattcc gtccacgatc tcgatgccgg cgcactgctc
      781 ctcggaccac gactcgtact cctcggccgt gatctgctcg tgcatccacg ccggagccac
      841 catctcggca gtcatgacac gcctcccgga cactgtgcgg cgggcccgat cccgcttcac
      901 tcagcgtact gactcccacg cgccggggcg gcccggagac cttggtcgcc cgtgcacgag
      961 gccggcgccg aaggtgacac tgccagtgac agtctccgcg ggactgccct caggcagtgg
     1021 ctggctggcc ccgttccagc cgccgagcat gggggcatga ccacagcgga taccagtacg
     1081 agcgccgcag ccgcgcaccc gatccccgtc cggatgaccg gacgccaggt cgccgccctg
     1141 gtggtgctcc tggcttcgca gttcatgatg gccgccgact tctccgtgct gaacgtcgcg
     1201 ctgcccgagg tcggcaccgc cctcgggttc tccaccggca gcctgcagtg gatctccacc
     1261 acgttcgccc tgtgcgccgc cggatgcacc ctggtcttcg gacgcgtcgg cgactacgtg
     1321 gggcgccggc gcatcttcac cgccggcatg gccgtcctcg ccgtctcgtc cctcgtcggc
     1381 ggcatcgcgg agtcgcccgc gatgctgctg accgcccgca ccctccaggg cctggccacg
     1441 gcggccgtca cgcccgccgc gctcgcgctg ctcaccaccg ccttcaccga gccctccctg
     1501 cgcacccgcg ccctcggcct gaacagcgtg atgatgagct ccggcttcag cgtcggcgcc
     1561 atcctcggcg gattcctcac cgacgtcttc tcctggcgct gggcgttctt catcaacatc
     1621 cccgtggccg tcgcggccat cctgatcgtg ccgttggtcg tcgacgagag ccgcgccgag
     1681 aagcgcagcc ggatcgacct gcccggtgcc gtgctcatca ccctcggcct gttctccgcg
     1741 atctacggcg tcacccgggt cggcgaggac gggttcgacc tcgtcgccgg cgcctccctg
     1801 gtcgccgccg ccgtactgct cggcgtcttc tgggccgtgc agagccgtac cgtcgacgcc
     1861 ctggtgccgg tgcgggtcct gaagaagccc gacatcgcct tcggcaacct ggccgccctg
     1921 ttcatcttcg gcggcgagac cgcgctgatc ttcttcaccg gcctgtacgt ccaggacgtc
     1981 ctcggcctgt cctccctcgc cgccggtctg gtgctgctcg gcatcggcgt cggccagatc
     2041 atcgccggta cggtcgggcc gcgcatcctc cagcgcgtcc ctccgcgcac gctgctcggt
     2101 gtctccctgt tcctccaggg cgcgttcatg ctgcccgcgc tgtgggcgac ctcggacacc
     2161 cgctggctga tcccgctgat cgccacccag ttcgtcaacg cgttcttctc catgacggca
     2221 gccctgtcct tcatggtcat cgccacctcc tccgtcgact ccgacatgca gggcatggcg
     2281 accggcatgg ccacccagag ccagcaggtc ggcatcgcca tcggcatccc gctgatcagc
     2341 gcggtgttcg cggccgtcat cgggcacggc acggtgacgg cggccgagga actgagcggt
     2401 atccacacgg cgatcggcgt cgccggcggc tgccaggtcg tggtcggcct gctgctgtgg
     2461 gcggtgctgc gccgcaagac ggccctgccg ggctgagacc cgggcagcgg ccccacgcgg
     2521 ccgggaaggc ggatcccccg taccgcctcc ccggccgtcg tggcatccat caccgctcct
     2581 cggggcggca ttgccgatcc cgtacggcac ctcataatcg aaagggtgga gcacatcgtg
     2641 aacacggacc tcggcagcta cctgcgccag atgcgcgagc gcgtgcggcc cgagcagatg
     2701 ggactgcgct ccagcggctc ccggcgggtc ccggggctgc ggcgcgagga ggtggccgcg
     2761 ctcgcgggag tgagccagac ctactacacg cggctggagc agtcgcagac cgcgcacgcc
     2821 tcgccgcagg tgctgctctc catcgcccgc gccctgcaac tgagccccga cgagcaggac
     2881 tacctgctca agatcggcac gccggtgcag aacccgcacg cgccggcgcc gtgcggcgac
     2941 caggtgagcc cgtacacgag gatgctggtg gagtccctcg ggaacgtggc ggcggccgtg
     3001 ctgaactacc gctgcgacat cctcagctgg aactccctct accaccggct gttcgcgccg
     3061 cacatcgact tcgaggcccc cgagcgcgcc gaacaacggc cgaacatcat caagatgaac
     3121 ttcctcgacg acgaggtccg ctcgctgtac gccgactggg ccgcggagtc ggagtcgaac
     3181 gtgacgtacc tgcgattcat ctccgccgac caccggcacg atccgcagct ggccgagctg
     3241 atcggtgaac tcacgatcca gagcgaggag ttcgcggagc tgtggtgccg ccagcgggtg
     3301 tccaactgca tcgagggcac caagctcttc gaccatccgg tcgtgggcga gctggagttg
     3361 atgtaccagt ccgcggacct tcaggacggc aacatcctga agttctacca cgccgatccg
     3421 gactccccgc acgaagcggc acttcggctg ctgacggtgg acctggactc ggtgcaccac
     3481 cgctgacccg cgcggacgac ggtacgaccg caccccggcc cgcagggacc ggggtgcggt
     3541 ggttcggcgc cgtcacgtcc gccgcagcgc cgtgaccccc caggtgaaac ccgacccggc
     3601 cgtcgccacg atcaccaggt cgccgggacc gatccggtcc tcccgctcca gctcctccag
     3661 ggcctggagc gggtcgacac cgccgaggtg gccgtcgcgc tcgtactgga acacgctgcg
     3721 ggaggcgtcc accccgagcg cggccaggta cgagcggtgg gtgtcctggt tgccgtgcgt
     3781 gacgaggaag tgggccacct cggccacgcc ggcgccgatg ccggcgagga ccctgtgcgt
     3841 cagggtggtg aagttgtcca ggaaggcgtc accgaggccg tcctgcttcc cgccccgctc
     3901 gaccttgatc cggccgtcct tgatctcgcc gtagtaggag tccacccact gcgggtcggt
     3961 gtggtgggcc ccgcccagca cctcgtaccg ggtggccgcc gcgtcggcgg tgagcagcac
     4021 cgcggccgcg ccgtccgcga agttgaacag ttcgaggtat ccggtgccgt actcgacgag
     4081 ttcgctgagc cggtccgcga tgatcaccag cgcgtacggg tgcgtgcccg cccgcacctg
     4141 gtcgtcggcc agcttcacgg ccaccatgcc ggcgttgcag aagttggaga cctcgtagca
     4201 gtgcgcctgg gtgatcccca gctcgcccgc gatcttggcc gcgggcgacc agaacggcgt
     4261 gccccattcg ctggagcccg cgtagaggac gaggccgatc tcctccagcg gcacggggct
     4321 gcgggccagc agccgggccg cggcgtcccg gcccaggccc caggccgtct cgccctcggc
     4381 cagcaccgag aacttccccg acggcaggac ctgcccgagc ttgtccaggc cgtagccgga
     4441 ctcccgggcg acctcgtcga cgctgcgctt gccactgggc atcgccaggg cgtagtcggc
     4501 tattcccacg gttcctccac ctgcctgtca gacgtattcc acgacggcgt gcggcacata
     4561 gggcgccgcg agccgggccg cctcggtgtc gtcgagttcc agttccaggg cggccaccgc
     4621 gtcctggagg tgatgcggtt tcgtcgctcc gacgacgggt gcggtgaccg ccggctgccg
     4681 cagcagccac gccagggcca cctgtgccat gggcacgccc cgctcggcgg cgatctgcgc
     4741 gaccacccgg gtgaccgcgc ggtcggcctc ctcggtgggg gcgtagaacc ggtcctggac
     4801 cggatcgccg gccgtgcgcg ccgactccgt ctcccagtcc cgggcgagcc ggccgcgggc
     4861 cagcgggctc catggggtga cgccgacgcc ctcggccagg cagtacggca gcatctcccg
     4921 ctcttcctcg cggttgatga ggttgtagtg gttctgcatg ctcacgaacc gggtccaccc
     4981 gtgcaggtcc gcgacgtact gcgccttcac gaactgccag gtgtgcatcg acgacgcgcc
     5041 gaggtagcgg acctttccgg cgcgcacgac gtcgtgcagc gcctccatcg tctcctcgat
     5101 cggtgtgtga gggtcccagc ggtggacgat gtagaggtcg atgtagtcgg tgtccaaccg
     5161 gcgcaggctc gcgtcgagtt cccgcatgac ggccgagcgg gacaggccgc cggagagcgg
     5221 gttggcgtcg agcttctcgt acaccttcgt cgcgatcacg acgtcctcac ggcgcgtcag
     5281 cttccgcagg ccgcggccga ggaactcctc gctggtgccg agggagtaga tgttcgcggt
     5341 gtcgaagaag gtgatgccga ggtcgagggc ctgtgcgagg aagggcaggc tctcctcctc
     5401 gggcagcgac caggggtggg tgccgaggcc gggctcgccg tagctcatgc agcccagcgc
     5461 gaggcgggac accttcaggc cggacgagcc cagtcgtacg tactgcacgt cggttacctc
     5521 agccctcgac ctcgtcctgg acctcggtca gccggcccca ggaggcgatg ccctcgtcca
     5581 gggggatgtc gaggctggcg aggtacatgg cggtcatggc gctgtggccc gcgaggtggg
     5641 tgacctcggc gatctcgttc tcggagtagt acgtgcgcag cccccagtac gcctcctcgc
     5701 tcgccttgtg gtcgaccatg cagtcggtga cgtagcggac cagcgcggcg cgctcggccg
     5761 gcagttcgtc gtacagggcg tcctcgatcg ccttgatctc ggtgtcgtcc aggccggcct
     5821 tcctcgccag cgggtagtgc agcaggcgct cgaactcgct gtcgcgcagc ttggccacgc
     5881 gcagcacgat cacctcgcgg tccagcaggc tcagcaggcc gaccgtgaag gtgccgccga
     5941 gcgcgaggtg ggcggcggcc gagttcttgg tcagcagcag cgcgcgggtc aggttggact
     6001 cgaacttctc gtacacggac cgctgttcgg gcgtcatgtc ggcgacttcg gtgagggtga
     6061 cgcggggggt catggagagc tcctcggagt tcggtaaggg cagggggtga gtggttacgc
     6121 gggtacggcg gtgagggccg ccggtgccgt gtcgcgcaca cggtgggcga gcgcccgggc
     6181 gacggtgcgc acgcaggtct cgggcgcgtg cgcgtccagc gggaccaggg tgtccaggtg
     6241 gccgtccgga cggacgagca acgcgtgcgc cgcgcgcggg agtctgccga gcagcgggcc
     6301 gggcggccgg ccgccgaggt cggcgagcgc ggcgccggac gtctcggcgc gcaccgcgtc
     6361 gacgacgcgt gtccagtgtt cgtggcggta ccggagcccc ggccacagca ggaccgtgaa
     6421 ccggtccacg gcgagcacgg gctgggtgct ggacccgcgc cagcccagcg gcagccgctc
     6481 gcccggcacc agggtgctcc gcctcggccg ggcgccgtag tgggtgtcga tctgggcgag
     6541 ccggggcgcg agcgccttct ccagggcgcg ggtcgcgctg cccagccggt agacggcgtc
     6601 gcgggccagg gtccggcgcc gggaggagta caggccgatc cgggcgaggc gggtggacag
     6661 cgcggccacc cggtcgacgg ccggcctgcg ctcggtgtcg tagctgtcca gcagctcggg
     6721 gtggtagtcg ccgcgcacca caccggccag cttccagccc aggttgaccg cgtcctggat
     6781 gccggtgttc aggccctgcg ctccggacgg gctcatggcg tgggccgcgt cgccgaccag
     6841 gaagacacgg tcgctgccgt acgtgctcgc cgagcggacg tgcgcggtga agacgccgct
     6901 gaaccgcatc tcaccgaggc gccgagcccc ggggacgcgt tcggcgagca gtgtctcgaa
     6961 gaaggcgcgg tcgggggtgt cgccgtggta gccgtcgggc acgctcgcgc cgacccggaa
     7021 gaccccgtca ccgagcggcg ccagcaccat gttgccggtg cgggtgaagt agtaggcggc
     7081 ttcgctgctg gtcgtctcgc caaggatctc ggcgtcggtg atcgccagcc gggtcctgag
     7141 ggtgcggccg gcgaaccgga agccgaacgc ctcgcggacg gcactgttgt acccgtcggc
     7201 cccgaccacg tagtcgtagg tacgggactg ttcggtgccg tcgggcagac ggagccggca
     7261 gtccacgccg tgcgggtggc gggtgccctc gaggaaggtg tggtcgtagt cgacggcgcc
     7321 gccgagtccg gcgaggtgct cttcgaggat cgcctcggtg cgccactgcg ggatggtgat
     7381 ggcgaagggg tagccgacgc cgcgcaaccg gtcgaagcgg accaagccga ccatcttctt
     7441 gttcgagtag tagttcatct ggtcgaagta gtgaccgcct tcgaccagtt ttcggcccac
     7501 gcccacccgg tccagcagtt ccaggacgcg cggccacagg atggtggccc gggagtgcgg
     7561 gctctgcctg cggagcttgg agacgacgtc ggcccggaca ccgtgcgcga ggagttcggc
     7621 ggcgagcacc atccccacgg gaccggcccc gacgacgagg acgcgtggtc gctgcatgtc
     7681 gctcaccacg gctcaggcac cgagcgcgcg caggcggtgg acgtacggcg ggcggacgaa
     7741 cgagccctcg gtgcgggcca ggaagtcggc tacgtacggc tccttcatgt gcaggtcgat
     7801 ggcctcctgg tcggcccagt cctccaccag cacgacgacg tcccggtgct cctcggaccg
     7861 gaaggcgtcg aagcgcagcg cgccctcctc ctcgcgggtc gcgtcgcaca gctcctggaa
     7921 cgcggccgtg accgagtcca tgcggtccgg cacgacgtcg aagacgacgg tgatctcgat
     7981 gctcatgtgt gggtcacttc cttggcgtgg tcgacgaggt cgacgaaggt cacaggtggg
     8041 gaggggcggc ccgtagcggc gcactcccgc gggtcggcgt tccaccggcg cagggcgacc
     8101 cgggctcggc cccgcgcggt ccactcggcg tccaggcaga gcgcgcggca cgtgccgacc
     8161 atgagccggg gcggctcgtc accggcggcg agcagggacc tggccagcag gttcagcacc
     8221 ccgccgtgcg ccaccacgag gacctgcccc gcggtccgct ccgcggcgag cacctcgtgc
     8281 agtgccgcgc agaaccgggt ccgcgcggca tggccgctct cgccgcccgg cggtgcgtag
     8341 ccggggtcgt ccagcagccg tcgcagcgtg gcgggccggc tccgggcgaa ctcggcgcgg
     8401 gacagcccgt cgagaccgcc gagatggcgc tcgcgcaggc cgtcgacccg gtggtggggt
     8461 acgtcgagcc ggcccgcggc gtacgcggcg gtctgggctg cccgggccat cggcgaggag
     8521 tagaccgccg cccagtcgcc gggcggcagc gagcgcgcgg cccgctgggc ctgccgcacc
     8581 ccctcgtcgt tgagcgggat gtcggcctgg ccctggaaac ggtcggcggc gttgcggtcg
     8641 gtctccgcgt gccggagcag gacgacgcgc acggctcaga cggcgctgcc gacggctgcc
     8701 ggggcaccga gggcctcgac ggcgcgggcg gcttcgtcga tgctctgctg ggaggtcagc
     8761 actccttcgg cgatggagac gccgagccgc ttctccagca gcagcgacat ctccagcagg
     8821 gccagggagt ccaccgcgag gtcctcgaag acggtgctcc gggcgacctc ctcctgcggt
     8881 atctcgaact ttccggtgag gatctcgatg atcatcgtgg acacggaacc ggtcatgggg
     8941 cacctcggga cgtgaggggt gtacagggaa cgagcaggcc gcgacggtgg ggcctgtcgg
     9001 gttcagccga tcggcagatc gggccagacg agggtggccg agccccaggt ggcgccgccg
     9061 ccgaacgcgg tcagcagcac ccggtcgccg gccgtgaggg tgccgtcggc caggccgtcg
     9121 gcgagggcga gcgggatgga ggcggcggag gtgttgccga cgcgctcgat gttgagcacg
     9181 gcgcgctccg gcggcagccc gagctgttcg gccacggcgt ggatgatgcg ggtgttggcc
     9241 tggtggccca cgagccggtc gacgtccgcg acctcccagc cggtgcgggc cagggccgtg
     9301 cgcgaggact ccgccatccg gcgcaccgcg gcgaagaaca cggacttgcc gtccatccgg
     9361 aagtaccggt cctccgggcg ggggaccccg ccccgggacc gctcctcggc tccgccgccg
     9421 cgcaccgtga tcaggtccgc catcgagccg tcgctgccga ggtggacgtc caggaccgca
     9481 cccggctcgg tgcgctcacc ggaccgcagc agtaccgcgc ccgccccgtc gccgaagatc
     9541 acggacgtgg tgcggtccgc cgggtccagg atggtgctga aggactcggc gccgacgacc
     9601 agcacccgct cggcgaagcc cgcggtgacg gcggcggcgc cggcctggag cgcgtagacg
     9661 aagccggagc acacggccgc gacgtcgtac gccggtacgc cggtcaggcc caggcgggcg
     9721 gccacggccg gcgccgtcgc cgggcacggg cggtccggcg tggtggtggc gacgatcacc
     9781 aggtcggcgc cgtcggcacc ggcgttcttc agggcccgcc cgccggcctc gacggccagg
     9841 tcgccggtgc tggtgcccgg gtcgacgaca tggcgcgcgg cgatgccggt ccgggtgcgg
     9901 atccaggcgt cggacgtgtc caggcgccgg gacagctcct cgttggtcac cacgcgcggg
     9961 ggcacgtagc cgcccacgcc ggcgagtacg gcggcccggg tcatgccggc accttcccgt
    10021 ccgggagccg gtgggcgacc gcggagcgca cccggagacc ggcgagttcg gccaccacgt
    10081 ccagcgtgcg ccaggtgcct ttgcccatgc gcagcagccc gggctcgtcc agtgcggtcg
    10141 tcaccggcac cgccgtcgtg gggcggtccg ggcgggcggc ggtcagcgtg gtctgccgca
    10201 tccacagggt gttgctgtcc tggcggcgca tgtcgtcgag gtcgtagagc atgatctggg
    10261 cgagctggag ggccgtgacg aaggcgtcga ccatcgacac gcagggttgg tgcgcaccct
    10321 ccagacccgc ggtgggcacc accgcgccgt cctcgtggac gacggtcagc gcggcctcgg
    10381 cgctcagcgc ccggtggtcc accgcgacgt cgcggacgag ctgacgccgg gtggtgaacc
    10441 cggtaccgaa gtagcggtcc gccgccgggc cgaggagggc gtccaggccg gcgtacgggc
    10501 cggaggccgg gaccgtcccc gtgggcaggg cgtggacgac ctcgcaccgc gtccgcatgg
    10561 tgccgaccgc gcagtcgacc agggagaccg cgcgcccggg ttccccggcg agcgggtcgg
    10621 tgcggcgcag cgtcgcctcg gccggcagcc gtgcgaggtc ctcctgcggg ctggtgccgg
    10681 ctgtgatccg taccttgcgc agccagccgt cgcgcaggtc cgggacgagg ccggtgaggc
    10741 acgcctcggc gagctgggcg gcgacgacga ggccgtcgac ggtgctgaag tgggggagca
    10801 gatcggtgcc ggccgccttc ttcgaccagt cggcggggta cctgacgccc accgaggacg
    10861 cggcccgcac ggtcccgtcc gctccacggg tgaggcgcag ttcgccgatg tcgtaggcga
    10921 cccggcggaa gccgcggccg aagaagcgct gctcggccgg gccgaggtgg tcgtcgacgg
    10981 acgccaccac ggtcggtgct gaagtcgggg tcatcggtgc tccgttcgtc ggggttggtc
    11041 ctgcgcgggc cttcggcggg gcgccgtgcg cccgcccggt ccgcgccggt cgccgcgccg
    11101 gacggcgcag gtgagccgcg ccgtgcaggt ccggttgccg gagtcatcgg tgatgacgat
    11161 ctcgtacgag gccatggcct gccgctcgcc caggggccgg cacaccccgg tgacggtccc
    11221 cgaggagacc cagcggtggt gggtgcatga caggtcgacc cccacggcgt tgccgccggg
    11281 ccccgcgtgc aggaacgcgg cgagggaacc cagggtctcc gcgaggacgg cattggcgcc
    11341 gccgtgcaga atccccaccg gctggcgatt gcccgagatg ggcatggtgc ccaccacgag
    11401 tcccggttcg caggtgacga tttctatacc catgcgtcgg gtcagttgtt cgccttcgta
    11461 tgcaccgtcg acccgcatcg ggccgagcat gatgttcggc atcacggtct ccgtctgttt
    11521 ccgggcccgc accggcgggc cgattcgagt caaacaccgc gacgtgaaag gcgacagcct
    11581 catggcctgt tgctgccaag tagctggcgc ttttaccaaa tccaggaaga cttgttctcg
    11641 cctggtaacc cgcaggaaag atgcgaatgc ttcggtgcgg gtgcccattc gtgcttggat
    11701 gggtgcggag ttgagaaaag aaaggggcgc ggtctcagtg cagcgcgttt cgctcggcgg
    11761 tcttgatgtt tccggcatcg gcctgggcgc catgtcgatg tccgactact acacgggagc
    11821 gggcaacgac gaggaggagg ccgtccgcac gatccggcgg gcactggacc tcggcgtcga
    11881 cctcatcgac accgccgaga tctacggccc gttcgtgaac gaggagctgg tcgggcgggc
    11941 cgtcgccgga cggcgtgacg aggtggtgat cgccaccaag ttcgggctgg tctcgcacga
    12001 cggcggcggt ccgaacgtgc tcgacagctc accggccaat gtgcgcaagg cggtggaggg
    12061 ttcgctcagg cgcctgggca ccgaccacat cgacctctac taccagcacc gcgtcgaccc
    12121 ggacacgccg atcgaggaca ccatgggcgc gctcgccgag ctggtgcgcg agggcaaggt
    12181 ccggcacgtc ggactgtccg aggccggccc ggacaccatc cggcgcgccc actccgtgca
    12241 ccccgtgacg gcggtgcaga ccgagtactc gctgtggtcc cgggagcccg ccgagacgct
    12301 gctgccgctc ctgcgggagt tgggcgccgg gctcgtcgcc tactcgccgc tcggccgggg
    12361 tttcctgacc ggcaccatcc gctccacccg ggagttcgcc ccggacgact tccggctgtc
    12421 cacaccccgg ttcgccgagg ggaacttcga gcggaacctg cgcatcgtcg acgaggtgga
    12481 ggacgtggcc cggagcgtcg gggccacccc cgcgcaggtc gcgctcgcct ggctgctcgc
    12541 ccagggcgac ggcatcgtcc ccgtccccgg cacccggcgc gtgacccgcg tcgaggagaa
    12601 cgccgccgcg gccgaggtcg tcctcacgtc cgggcaactg gcccggctcg acgcgctcac
    12661 cccgcccgtc ggcgaccgat acgccgagca ggacctggcc cgcacgggac tgtaggaccc
    12721 ccgcggggcc ccgggccggg gccgttcaga tccactgccg ccgggccgct tccacccccg
    12781 cctggaagcg gctctgggca cccatcctgg acatcacgcc cgctatggtc cggcggaccg
    12841 tgcggaccga caggccggtg cggcgggaga tgccctcgtc ggtcagcccc tcggcgagaa
    12901 gcaccagcgc ctctcgctcc cgctcgtcca gcccgccgcg cccgggcccg ccggccccgc
    12961 tgtccgtcgg caccggcgcg cagcccgccc acacctggtc gaacagggcc tggtggccgg
    13021 cgaccagaga ccgtccgcgc agcagtgtgg ccgaggactc acccagtgcg gggtccgacg
    13081 gcacgatcgc cagatcgcgg tcgaccacgg ccatccacac cggcagccgc ggcaggcccc
    13141 gcacctgcgc gccggacgcc gcgatccgcc gcaggtcctc ggcctgggcg ggatcgcggg
    13201 cgacgtccgc cggatgcagg acgcgcaccc gcgcgccacg gcggaccagt tccccgctga
    13261 gcagtgccgc ccgctcccgc acccggcggt cgtaggggcg ccggggcagc gcgagccgta
    13321 actcgcgcac cgcgcggtgg tgcagggcgt ccagttggtc cgccacggag tcggagtcgg
    13381 tcagcggctg aagtgccgtc cgtgtggtgt cggatctgac gagcgtctga ctttccatgt
    13441 caccattccg cagcaaaaag agatacccgg acttggcacg gaccccccgt gcagcgcaac
    13501 ccgcagtccc caacaggagg taaagatccg gaatggaagg taaagagctg ccgctgtgag
    13561 ggcagaatcc acacgggtct caggctgcgc ctcaatgagg ttgcaagtgc tcttcaaggc
    13621 ttgtcaagcg gcaaaaactt gccgcttgcc agtcatctct ttctgtgtag agttggtggc
    13681 gcacaggcac tgttacgccg gcatcagagc cacgaagcgg gcgcctggcc ggtaagcggg
    13741 gaggaggacc tgggcggtga caaccaactc ggtctgggaa acatggggga gtgcgaggcg
    13801 gaattttccg ccctgccgga acgcgatgat gcggggcccg gcattccaga gttcacgaca
    13861 gaccggctcg tgctggacac tcgtcagtaa atcattgaga gtcgggtcgt ccggactgcg
    13921 aaagagcgcg aatctcaact gtgcgagata cagcgcggcc tgtttcctcc attccactat
    13981 ctgttcacgc gattcggggt tcagcagaac ccagcgcatc agattggctt ccggctcacg
    14041 gacccaggga aaccaccggg ccatgagcgc gttgtaggtg atgatgttcc acgcgtggtc
    14101 gatgagatag gccggaaacg tcgtctgtgc gtcgaccagg tccttgagcc ggcccagtct
    14161 gccgccgtcg tccgccgtcc gctcctcgtc cgacacctcg gccagccggt accagtacaa
    14221 cgccgtacgt tcgtccggtc cgaggtccag cgcttctgcg agctgggtca acgtgtccag
    14281 ggtgagcgga acctgagccc cgctctccag cgcgcggtac cagcgctcgc tgacgcccat
    14341 gcgctgggcg acctccttct gcggcagcgc cttgccccgt ccgagcttgg cgcccgcctc
    14401 tgtgcgccag gcccgcaaga ggtgcggaag gtcagcgaat tcgagctgga attccgctgc
    14461 ttcgggtatg tctgaaccac gcgattccgt catgtttccc ccgttcgtgg catgtcttcg
    14521 aacgatcaaa cactagtcgg aggcgtcgtc gaccccttgg ggcgtgagcg cgtccgaagc
    14581 cgcgatcacc atgcagtcga tcaacgggcc cgcatggaga acgtgcggga agtcgtagga
    14641 aagagaaggg aaagcgattg ccatgagaaa tgtcaggtac atgtccagac gggtcgtcgt
    14701 caccggcctc ggcaccatgt ccccgctcgg cgcaggcacc gactccctct gggaagggct
    14761 gctcgccggc cgttgcggca tccggccact gacgggcgcc gagttcgcgg cgcacccggt
    14821 caggatcgcc gggaccgtcc ccgtcgaccc cgccgggctg ctgcccccgc cgcgggcacg
    14881 gcggatgaac cggggcgcgc tgctggcggt gacggcggcc agggaggcat ggcgggacgc
    14941 cgggttctgt gcgggcggca cccgggacag cggcctcgac ccggaccggg tcggggtgag
    15001 cgtcggcacc atcatcggcg gcgccggcgt actcgtggag ggtgcccgtc ggctgcggga
    15061 ccggggtgcc cgggcggtgc caccgctcac cgcgcccatg accgtgccct cccaggcggc
    15121 gtcccagatc tcgctcgatc tgtgcatcac cggggaggcc cgcaccgtgg tcagcgcgtg
    15181 cgcctccggt acggaggcca tcgggcaggc catcgaccgc atccggtacg gccatgtcga
    15241 catcgcgctc gccggcgggg cggaggccgc cgtgacgccc gaggtcatgg ccgcgttcag
    15301 cgcgatgcgc gcgctgtccg cccgtaacga cacccccgaa gccgcctccc ggcccttcgc
    15361 caaggacagg gagggcttcg tgaacagcga aggggcaggg ctgctggtgc tggagtcgga
    15421 ggaacacgcg ctggctcgcg gcgcccggat ctactgcgag gccgcgggct ggggcctgtc
    15481 ggccgacgcc taccacatgg ccgcgccgga cccgacgggc ggcggagtgg cgaccgccct
    15541 gcggcgcgcg gtcacggacg cggggtcccg taccgccgac gtggtgcaca tcaacgcgca
    15601 cgccacgggg accgtcgagg gcgacctcgc ggaggcggca gctctgagca ccgtcttcgg
    15661 cgacgcggac ggcgccgtcc ccgtgccggt caccgccctc aagggaagcc tggggcacct
    15721 tcagggcgcc gcgggcggtg tggaggcggt ggcgacggca ctcactctgc accacgggat
    15781 catcccgccg accacgggct gcgacgatct cgacgacgcg atcccgctcg acgtggtcac
    15841 caacctcgcc cgcccgctac ccgcccgcgg tgacctggcc ctcagcaact cgttcggctt
    15901 cggcggccac aacgcggtcc tggccctgcg gcgccggtga ggtccacggt ggccggcgaa
    15961 tcccgcgcac gccggtgaca ccacggccgg gccggggcct cgcgggccgt ggcgcaaacg
    16021 tcctgcggtc ggtccctgcc tccgcgcggc ccgcaggccc gttctccgcc ggagctgcgc
    16081 gctccgccgg ttgggccgca cacggcgaga cggctcacca gggtgtggtg cggtcgaggg
    16141 gcgcccgggt gggctgtgga tggtggaaaa accggccggt gtgtgagcgc gtgcaccagc
    16201 agctcagggg gacgatggtg cgggcctacc ggccgtgcgg gaaggccgcg ccggtccacc
    16261 ggcatcccga cgaggagcgg caacgggagg tcgccgggct cgacgacaac aaagagcccc
    16321 aggtttctaa tctgggggtt tcacgcggag cgggtgacga gaatcgaact cgcgctctca
    16381 gcttgggaag cgacggcgct tgcgcgcgcg tgaagctgct gacctgcgtg gatccaatgt
    16441 gctgcggtag gcgtggacgt tctgtggcac tgctgttgac cgtaggtgtc cgctctgaag
    16501 ggcacaccgt gggcacgaca ctgcgatgtg gacgaccact tcgctgatgt ggattgctcg
    16561 gtgtgcgggc ttggggatgc acagagtggc tgacgcggca gtcgcggtcg cacatggctg
    16621 ccgggccctc gcctcggctc ggtgggcgcg gccggcatct gatgatccga agaacgaggc
    16681 acctgcgtgt gtcaatccgg tacatggact actcttggta catgtccatg aagcgcacga
    16741 acgtctacgc cgaccccgag gacctggcga tcatcaagga ggccgcgaag cgtcggggga
    16801 tcagcgaggc cgagatcatc cgccagggca tccacctcgc ggccatggcg aacagggtct
    16861 gggacgagcc gctgttctcg cgcaccttcg aggggacggg ccgcacgccc tccaaggcgg
    16921 aggtccgtga tgcggtcgcc gacgccgtcc gccgtgaggc cgactcgagt tccggaaccg
    16981 ccgcgtgatc attgtcatcg ccgacacgtc cggcctcctg gcggccctgg actcggctca
    17041 cccggaacac cgggcggcga acgaggcgat catggcggcg ggcctcctgg tcatgtcccc
    17101 attgctgctg gccgaactgg accacgtcgc cacgcgcgag ctcggcaggg cggccgccct
    17161 cggcgcggtc gacgacctcc ggcgctggat gagccggggg cgcgtcgtca tgccggagat
    17221 cacggagggc cacctgggcg ccgcccagtc cgtccgtgtc cgctaccgtg cgctggacct
    17281 cgacctcgcc gacgcggtca acgtggcgct cgccgccgac tacgacacgg acgcgatcct
    17341 caccctcgac cgacgtgact tccgggccgt acgccccttg ggccaccaca aggtgtttcg
    17401 ggtactcccc gacgatctcc cgctctgata cgacgagagc tgaacttgcg ctcgtcgctc
    17461 gggaagtgac ggtgctcggg caactcgtgc ggctctggta cgcacggatg ttgtgcagca
    17521 gggtgggaac ggtggtcgct gagaacacgt gcagtcgtgt ctccaccatg ctgtccgcgc
    17581 tacgtcggcc tcacttccgt ggggttcacg caggagctct cccacacctg tctgcagtcg
    17641 gccaactctg aacgacctga cacgcttttc ggaacatcct ggtgcggccg cgcgcgttca
    17701 cctctgctgg gaagcaccgc gtgcgcgggc cacagctcaa ccgtcgggca gagtgtacaa
    17761 acggtgcgat tccctggtcg gtgtagacga caaagaaggc ccgggtctct gacctgggcc
    17821 ttcttcatgg agcgggtgac gagaatcgaa ctcgcgctct cagcttggga agctgatgtt
    17881 ctaccattaa actacacccg cgtaagacgc cgaccgaggt cggtgcctgg acgctccgtc
    17941 actctacccc atcgtcggtc cccggtgtcc gcgccgtggg accgacgcgc gttccggggg
    18001 tgtgacgcgg ctgcggagcg ccggagttgg ggcgtacggt gggggccctg gagagggtcc
    18061 gggaggggcc ggagtgccgc ctggagagtc gtctctttga tcccgtactg tggcttttgt
    18121 cgtcagggta gtcagccaga cgcggctctt ggggaaggga cttgaaggac ttgatggatc
    18181 acaccgtcct ccgctgtgcc gatgggcacg tgttcaccgc cgcctcgttc ccgatgcaga
    18241 aggccgagcg gctcggcccc ggccggctcg tccgatgtcc gcggtgcgcg cggctgcgga
    18301 gtgccgtgcc ggtgggtgcg gtgaagcggt agcacacacc ccgggtgagg ttcgggcgcg
    18361 cggcgcggcg gcggttgtcg cagctccgcg cgccttgcgt atcctcggtg cgtgcttctc
    18421 tcagacaagg acatccgggc cgagatcgac gccgggcggg tccgcatcga tccctacgac
    18481 gactccatgg tgcagccgtc gagcatcgac gtgcgtctcg accgctactt ccgggtgttc
    18541 gagaatcacc ggtacccgca catcgacccc tcggtggagc aggcggacct gacccggctc
    18601 gtggagccgg agggcgacga gccgttcatc ctgcatcccg gcgagttcgt gctggccagt
    18661 acgtacgagg tcgtctcgct gcccgacgat ctcgcctcac ggctggaggg gaagagctcg
    18721 ctggggcggc tcgggctcgt cacgcactcc accgccgggt tcatcgaccc cgggttctcc
    18781 gggcacgtga cgctcgagct cagcaatctc gcgaccctgc ccatcaagct gtggccgggc
    18841 atgaagatcg ggcagctgtg catgttccgg ctcacgtcgc cggccgagca cccgtacggg
    18901 agcgagcggt acgggtcccg ttaccagggg cagcgggggc cgaccgcctc ccggtccttc
    18961 atcaacttcc atcggaccca ggtatgagca ggacgcgcgc atgagtgatg tacgggagaa
    19021 cctgacctac gagcagttcg gcgtcgcggt gcgcgagctc gctcaggccg tcgccgacga
    19081 cggctacgag cccgacatag tgctgtcgat cgcccgcggc ggcgtcttcg tcgccggcgg
    19141 tctggcgtac gcgctcgact gcaagaacat ccacctcgtg aacgtggagt tctacaccgg
    19201 ggtcgggacc accctggaga tgccggtcat gctggcgccc gtgcccaacg tgatcgactt
    19261 ctcccgcaag aaggtcctca tcacggacga cgtcgcggac accggcaaga cgctcaagct
    19321 ggtgcgggac ttctgcctgg acaccgtcgc cgaggtccgc agcgccgtga tctatgagaa
    19381 gtcccactcg ctcgtccagt gcgagtacgt gtggaagcgg accgacgact ggatcaactt
    19441 cccgtggagc gtccagccgc ccgtggtgcg caaggacggt caggtgctcg acgcctgagt
    19501 ggctgagcgt ccgggacgcg cggtacgtgg aagggccccc ggcgcgacgc cagggccccc
    19561 ggcgcgacgc cgggggccct tccacgtacc acgcgtcggc gactagaacg tgcccagctt
    19621 cacgatcgac agcagcgcga tcagctggat cgccgacgcg cccagcgcct tcggccaggg
    19681 caggtcgtgg gagcggccga ccatcagggt cagcagggcg cccgccgcga cccaggtggc
    19741 ccagcccagg atctggacga agggcgcgtc gccgccggcg aacagcgcga cgaccaggcg
    19801 cggggcgtcc gtgagggaca tgatcagcat ggagaggccg acggtgggct gccaggcgcc
    19861 gtcgccgccg agctggcggg ccagggtgtg ggtgaccacg cccaggacga acgcgctcag
    19921 caccatcgcc acggccgtgg tcaggacgat cgggaccgcg ttggagaggg tggcgttgat
    19981 cgcctcctcg cgggcgccgt cgaagccgaa gaccgccagc aggccgtaga ggaaggtcac
    20041 gatgagcgcc ggggcccaca tcgcgtagtc ccgcatctgg aggaaggtcg cgccgggggc
    20101 gaggacgacg cccctcagca gtgccttcca gtgcaggcgg ggaccgaccg gaccgggcgg
    20161 cggcgcggag ccggcgcggt aggtctcgcc ctggttgtag gggtcgtcga ccgtgaacgc
    20221 ctgcgtgtgg cccgggttgt tggccgcgta cgggtcgtgg ggggcctggc ccccgtgagg
    20281 gccgccctgg gggtggccgc cgtcgccgaa gtactccggc tcaccgtgcc cgccgccgtg
    20341 gggctgtggc cacggtgagc cgccggcgcc ggggccgggt ccgccacccc cgtacggctg
    20401 ctgcgggtac ggctgctgag gcgtcgcggg accgccgtac gacggtccct ggggcgcctg
    20461 ctgtccgtac ggagggcgtt gcggtcgcgc gtgcggagcg ccgttgtccc ggccgcgtcc
    20521 gatcctgaat ccagccacgc cttcgaacgt acctggtccc ggagagtgac gtgcggggcg
    20581 tggcctttcg gggcggcctt tgcggccgag ctgtgacatc ccttacgggg cacccccgag
    20641 gactccccga cctccccgcg gcgtccgcgc acgggtccgc cggtccgtcc cctacggggt
    20701 caggaacacc gacgtggaga acgtgaccgc cgcctccgcc gtcaccaggc cctcggccgc
    20761 gccccggtac accgcgacgg cgtcctgtgt gtcgccccgg tacgtccgca ccaccaggtc
    20821 cgccaggtcg tcgccgtcga agtcgccggt ggtcagcacc tgcgtcgtgc cggtcgccgc
    20881 ggggcgcacc gtgaccacgc ccgtggtcgc ggggcccgtg ccgcggcccg ggaggacccg
    20941 taccccgttg ccgctggaca ccagttcgct caggccgtcg ccgtcgaggt cggcggcgtc
    21001 gagcgtcgaa ccgg
//
