LOCUS       NZ_CP012382            10399 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2000971
            Orig. end                         :: 2011370
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="7"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(879..1391)
                     /locus_tag="SAM23877_RS09030"
                     /old_locus_tag="SAM23877_1936"
     CDS             complement(879..1391)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028017.1"
                     /locus_tag="SAM23877_RS09030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1936"
                     /product="hypothetical protein"
                     /protein_id="WP_053128728.1"
                     /transl_table=11
                     /translation="MSVLLLLVLVAVVTAVVLGRGAGTYGRRPYLAAGPAAAAARRPPR
                     AGAPFRAVAAVAGAGAVLLYAWGALCVGFAVMQAEDGGTGSSPMPPCRSGVSPEQAGRV
                     IDYEASLLPPRFRCETTDGGGYDSAEVPGYAGPGAAVLALTAVAGAVAAGWATGRRARA
                     SARKAVR"
     gene            1560..2690
                     /locus_tag="SAM23877_RS09035"
                     /old_locus_tag="SAM23877_1937"
     CDS             1560..2690
                     /NRPS_PKS="Domain: Aminotran_5 (74-301). E-value: 6.1e-28.
                     Score: 89.7. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS09035_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976957.1"
                     /locus_tag="SAM23877_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1937"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_053128730.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7.7e-21, bitscore:
                     73.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPFLDLAPLSAGRFAAIEDRVARLLGTGQDVVIMQGEALLPLE
                     GAIRAAAGPGTVALNIVTGPYGQTFGNWLRDCGATVHDLAVPFHTAVSAEQVRQAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEAVRAHGALFYLDAVASVGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPHAPRRSYLSLLDWKERWIDGGRKALLHAP
                     AQLEMLALEACVERIEAEGPETVMARHASAAAATRAGALALGGGLEPYVYEAKDAAPVA
                     TTLRVPSGTDASELVARALESDPALPLAAGGGALAREMIRVNHYGPDATPGAVQSCLAA
                     LGAALAETGARTDLGAARHAAESAWEAQTGTGLSGA"
     aSDomain        1782..2462
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS09035_Aminotran_5.1"
                     /evalue="6.10E-28"
                     /label="SAM23877_RS09035_Aminotran_5.1"
                     /locus_tag="SAM23877_RS09035"
                     /protein_end="301"
                     /protein_start="74"
                     /score="89.7"
                     /tool="antismash"
                     /translation="RDCGATVHDLAVPFHTAVSAEQVRQAFAEHPEIDFVSLVHAEAAT
                     GNTNPVAEIGEAVRAHGALFYLDAVASVGAEPVLPDAWGVDLCVIGAQKAMGGPAGVSA
                     VSVSERAWARMAANPHAPRRSYLSLLDWKERWIDGGRKALLHAPAQLEMLALEACVERI
                     EAEGPETVMARHASAAAATRAGALALGGGLEPYVYEAKDAAPVATTLRVPSGTDASELV
                     ARALE"
     misc_feature    2836..2853
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.5"
                     /tool="antismash"
     misc_feature    complement(2838..2853)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(2848..2863)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    2883..2896
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     misc_feature    3002..3018
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.23"
                     /tool="antismash"
     misc_feature    3004..3018
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            3018..3524
                     /gene="ectA"
                     /locus_tag="SAM23877_RS09040"
                     /old_locus_tag="SAM23877_1938"
     CDS             3018..3524
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448158.1"
                     /locus_tag="SAM23877_RS09040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1938"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_053128734.1"
                     /transl_table=11
                     /translation="MTAAQADLQIDRPRVADGAALWRIAKDSKVLDVNSSYSYLLWCRD
                     FAATSAVARDGHGVPVGFVTGYVRPDQPDTLLVWQVAVDEAYRGRKLAASMLDGLAART
                     LAECGTTTVETTISPDNTASQRLFTSFAERHGATLEREVLFDTDEFPDGPHEPEVLYRI
                     GPLGG"
     gene            3640..4911
                     /gene="ectB"
                     /locus_tag="SAM23877_RS09045"
                     /old_locus_tag="SAM23877_1939"
     CDS             3640..4911
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (29-366). E-value: 1.1e-71.
                     Score: 233.6. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS09045_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="SAM23877_RS09045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1939"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_053128736.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-75, bitscore:
                     252.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTIFDRAVGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNTILRPRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVEDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALSELCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGLPMS
                     LCLFKPELDVWEPGEHNGTFRGNNPAFVTATATLEAYWADGSAMEKQTRTRGEQVEQHM
                     IAITEENLADVKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLP
                     ALTITPDELDEGMKTLARAVRETA"
     aSDomain        3727..4737
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS09045_Aminotran_3.1"
                     /evalue="1.10E-71"
                     /label="SAM23877_RS09045_Aminotran_3.1"
                     /locus_tag="SAM23877_RS09045"
                     /protein_end="366"
                     /protein_start="29"
                     /score="233.6"
                     /tool="antismash"
                     /translation="DRAVGSRMYDEDGHEYLDFFAGAGSLNYGHNNAVLKRALIDYLER
                     DGVTHGLDMSTTAKRRFLETFQNTILRPRDLPYKVMFPGPTGTNAVEAALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFLWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALSELCERQDMLLIVDDIQMGCGRT
                     GAFFSFEEAGITPDIVTVSKSISGYGLPMSLCLFKPELDVWEPGEHNGTFRGNNPAFVT
                     ATATLEAYWADGSAMEKQTRTRGEQVEQHMIAITEENLADVKEYRGRGLVWGLEFH"
     gene            5001..5399
                     /locus_tag="SAM23877_RS09050"
                     /old_locus_tag="SAM23877_1940"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037840.1"
                     /locus_tag="SAM23877_RS09050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1940"
                     /product="ectoine synthase"
                     /protein_id="WP_053128738.1"
                     /sec_met_domain="ectoine_synt (E-value: 3.7e-54, bitscore:
                     180.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKEIEGTDRHVKSASGTWESKRIVLAKEKVGFSVHETILY
                     AGTETSMWYANHIEAVVCTQGDAELTDRETGKTYHITPGTMYLLNGHERHTLKVKEDFH
                     CICVFNPPVTGREDHDENGVYPLLTEEV"
     gene            5406..6305
                     /gene="thpD"
                     /locus_tag="SAM23877_RS09055"
                     /old_locus_tag="SAM23877_1941"
     CDS             5406..6305
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976953.1"
                     /locus_tag="SAM23877_RS09055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1941"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_174532204.1"
                     /sec_met_domain="PhyH (E-value: 3e-40, bitscore: 137.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITTTNITDLYPTRGATEVATPRRDPVVWGSPDTPGPVSAGDLQ
                     SLDRDGFLAIDQLIGPDEVDVYRRELERLTSDPAIRADERSIVEPQSKEIRSVFEVHKI
                     SEVFANLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     NMRTISVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGTPSDEA
                     LTKMASEYGIKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFA
                     APIRRPDFIGARDFTPVR"
     misc_feature    5427..5441
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            complement(6439..7533)
                     /locus_tag="SAM23877_RS09060"
                     /old_locus_tag="SAM23877_1942"
     CDS             complement(6439..7533)
                     /NRPS_PKS="Domain: Aminotran_5 (28-357). E-value: 6.3e-22.
                     Score: 69.9. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS09060_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448151.1"
                     /locus_tag="SAM23877_RS09060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1942"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_079030101.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1e-15, bitscore:
                     56.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGEVPWPHSGAMESFENLVRAEFDPKTTYLNTASTGLLPARTLA
                     AMRDAAEAAAAGEPSDMFADVEASRSAFARLTGVPSSRVAAGASVATFSGLVAAALPSG
                     AEVLTAEGDFSSLVNPFHMRGDLKVRSVPLERIAESVGPGTALVAVSSVQSADGRIAGL
                     AALRDAARVHGARTLIDASQSSGWLPLAAGEFDFVTAVAFKWLLCPRGVAFLVVPEDLG
                     AAAGLTPLFAGWASGERPWDSCYGPVGELAHSARRFDESPALFSYAGARHSLSLIADLG
                     VDAVHAHDTALADRFREGLASLGHGPVPAPGSAIVSVPALGHRQGELGRADVQVSDRAG
                     NLRAAFHAYNTPADVDRLLNVLAD"
     aSDomain        complement(6463..7449)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS09060_Aminotran_5.1"
                     /evalue="6.30E-22"
                     /label="SAM23877_RS09060_Aminotran_5.1"
                     /locus_tag="SAM23877_RS09060"
                     /protein_end="357"
                     /protein_start="28"
                     /score="69.9"
                     /tool="antismash"
                     /translation="TYLNTASTGLLPARTLAAMRDAAEAAAAGEPSDMFADVEASRSAF
                     ARLTGVPSSRVAAGASVATFSGLVAAALPSGAEVLTAEGDFSSLVNPFHMRGDLKVRSV
                     PLERIAESVGPGTALVAVSSVQSADGRIAGLAALRDAARVHGARTLIDASQSSGWLPLA
                     AGEFDFVTAVAFKWLLCPRGVAFLVVPEDLGAAAGLTPLFAGWASGERPWDSCYGPVGE
                     LAHSARRFDESPALFSYAGARHSLSLIADLGVDAVHAHDTALADRFREGLASLGHGPVP
                     APGSAIVSVPALGHRQGELGRADVQVSDRAGNLRAAFHAYNTPADVDR"
     misc_feature    7570..7583
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.49"
                     /tool="antismash"
     gene            complement(7593..8306)
                     /locus_tag="SAM23877_RS09065"
                     /old_locus_tag="SAM23877_1943"
     CDS             complement(7593..8306)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067467.1"
                     /locus_tag="SAM23877_RS09065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1943"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_053142312.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHRDEVEVVHRSFELDP
                     GRAKDDVQPVLTMLTAKYGMSEAQARAGEDNLGAQAAAEGLDYRTRGRDHGSTFDMHRL
                     LHLARESGRQEKLLDAFYRANFAEERSVFADDERLVELAVAAGLDADTARAVLADPTAY
                     ADEVRADEREAAELGASGVPFFVLDRAYGVSGAQPAEVFTRALTQAWGERTPLKPIGDG
                     DAEACGPDGCAVPRS"
     gene            complement(8383..8886)
                     /locus_tag="SAM23877_RS09070"
                     /old_locus_tag="SAM23877_1944"
     CDS             complement(8383..8886)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329308.1"
                     /locus_tag="SAM23877_RS09070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1944"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_174532205.1"
                     /transl_table=11
                     /translation="MIDTRLPGSPVIRTVLSAEAETVAALHARARATYYPDGPPDDGTD
                     WVAAWRGAVERPDGHVLCAVAGGDLVGVASFRVPEDGPAGTVRLFQFHIDPGHWRSGIG
                     TALHTACVEQWRADGRRTAVLDVHADNRRAQAFYGRQGWVPDPEEPPGAGDHHLSLRFA
                     VDGE"
     gene            complement(8924..9532)
                     /locus_tag="SAM23877_RS09075"
                     /old_locus_tag="SAM23877_1945"
     CDS             complement(8924..9532)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436202.1"
                     /locus_tag="SAM23877_RS09075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_1945"
                     /product="DUF1349 domain-containing protein"
                     /protein_id="WP_053128740.1"
                     /transl_table=11
                     /translation="MLLELPELPFPLRPYGPDGAWSYDGGVLTGRAGARQDRFVPPTGE
                     ALEPASDAPRLLGAPDGDFQLIARVTVGFQGAFDAGVLYVHVGERAWAKLCLEYSPDVP
                     TVCTVVTRGHSDDCNSFTVDGDSVWLRVSRSGRAFAFHASLDGERWTFVRLFTLGDEKE
                     TGAALVGFLAQAPTGEGCVVTYDRLELRPGFPADLRDGG"
     misc_feature    complement(10301..10316)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.08"
                     /tool="antismash"
ORIGIN
        1 gaccgggatg ccggcgtcgt aggcgctccg cacggtgtcg tagcggcgtt cgtggagccg
       61 gcgcatgtgg gcggaccagc gggggaacct ggactcgccg ccgtccgcga gcgcggggaa
      121 ggtggcgatg ttgaccaggg tcggcacgat ggcaacgccc cgctcggcga agagggggat
      181 cgtgtcgtcg gtcaggcccg tggcgtgctc gacgcagtcg atgccggcct cgaccaggtc
      241 ccgcagcgag tcctcggcga agcagtgggc ggtgacgcgg gcgcccaggc ggtgggcctc
      301 cgcgatcgcc gcctcgacgg cgccgcgcgg ccagcaggcg gacaggtcgc cgaggtcgcg
      361 gtcgatccag tcgccgacca gcttcaccca gccgtcgccc cgccggacct cctgggcgac
      421 gtacgcgacg aggtcctcgg gctcgacctc ccaggcgtag ttgcggatgt agcgccgggt
      481 gcgggcgatg tgccggccgg cccggatgat cttcgggagg tcctcgcggt cgtcgatcca
      541 gcgggtgtcg gagggcgaac ccgcgtcgcg gatgaggagg gtgcccgcct cccggtcggt
      601 cagcgcctgc ttctcggcga cgtcctcggg gacggccccg tgccggtcga ggccgacatg
      661 gcagtgggcg tcgaccaggc cgggcagcgc ccagcccgtg acggtgcgga cgtcggccgc
      721 gcccgcggga cggtcgtagg agatccggcc gtcgaccacc cacacctcgt cgcggacctc
      781 ctccggtccg accagcaccc gacccttcac gtgcagcacc gtgcgatcgc tcatgtcccg
      841 caccctagac cggtgcggcg gggtgttcga agggccggtc accggacggc cttccgggcg
      901 ctcgcgcggg cacgccgccc ggtcgcccac ccagcggcca cggcgcccgc gacggcggtc
      961 agggcgagca cggcggcccc gggtccggcg tagccgggga cctcggcgga gtcgtagccg
     1021 ccgccgtcgg tggtctcgca gcgaaagcgc ggcggcagga gcgaggcctc gtagtcgatc
     1081 acccgtccgg cctgttccgg ggagactccg gaacggcacg ggggcatggg cgaggagccc
     1141 gtgccgccgt cctcggcctg catcaccgcg aagcccacgc acagcgcgcc ccaggcgtac
     1201 agcaggacgg cacccgcgcc ggcgaccgct gcgaccgcac ggaagggcgc ccccgccctg
     1261 ggcggcctgc gagccgccgc ggccgcggga ccggccgcga ggtaggggcg gcgcccgtac
     1321 gtgccggcac cccggccgag gacgacggcc gtgaccacgg cgaccaggac gagcagcagg
     1381 agaacggaca cgaggccgag tccatcaggc cgacgatcgg cgtggctgtg gcggaagcca
     1441 caattccggg cgtgagggtg tcgcaacgga aaccctccgc gcgagtgacg gcaggggcca
     1501 tggttactct cgactccgta cgcgccgtac acctgcccgt tactgaagag agcaccgccg
     1561 tgagccaccc cttcctggac ctcgccccgc tgagcgccgg ccgtttcgcc gcgatcgagg
     1621 accgggtggc gcgcctgctc ggcaccggac aggacgtcgt gatcatgcag ggcgaggcgc
     1681 tgctgccgct ggagggcgcg atccgcgccg ccgccgggcc gggcaccgtc gcgctgaaca
     1741 tcgtcacggg gccgtacggg cagacgttcg ggaactggct gcgggactgc ggtgcgaccg
     1801 tgcacgacct cgccgtgccg ttccacacgg ccgtctccgc cgagcaggtc cgccaggcct
     1861 tcgccgagca cccggagatc gacttcgtct ccctggtgca cgcggaggcg gcgaccggga
     1921 acaccaaccc ggtcgcggag atcggcgagg cggtgcgggc gcacggcgca ctgttctacc
     1981 tggacgccgt ggcctccgtg ggcgccgagc cggtgctgcc ggacgcgtgg ggcgtggacc
     2041 tgtgcgtgat cggcgcgcag aaggcgatgg gcggtccggc cggtgtgtcg gcggtgtcgg
     2101 tgagcgagcg ggcctgggcg cggatggcgg ccaacccgca cgctccgcgc cggtcgtacc
     2161 tctccctgct ggactggaag gagcgctgga tcgacggcgg gcgcaaggcg ctgctgcacg
     2221 cgccggcgca gctggagatg ctcgccctgg aggcatgcgt ggagcgcatc gaggcggagg
     2281 gccccgagac ggtgatggcg cggcacgcct cggccgccgc ggccacccgt gccggtgcgc
     2341 tcgcgctggg cggcggtctg gagccgtacg tgtacgaggc gaaggacgcg gcgccggtgg
     2401 cgacgacgct gcgggtgccg tcgggcaccg acgcgtcgga gctggtggcc cgggccctgg
     2461 agtccgaccc cgcgctgccg ctggccgcgg gcgggggcgc gctggcgcgg gagatgatcc
     2521 gggtcaacca ctacggcccg gacgcgacgc ccggagccgt gcagagctgc ttggcggcac
     2581 tgggtgccgc actggccgag accggggccc ggacggacct cggggcggcc cggcacgccg
     2641 ccgagtccgc ctgggaggcg cagaccggca cgggcctttc cggagcgtga attcttggaa
     2701 tttgccgaag ccatcaaaag cgaattcggc aattcttcgg agtacagcca tccgtgttct
     2761 tcttcccgct ttccccggac ctaaactcta agatttcgat aagttcgaga ccggcatttc
     2821 ggacacgcgt cgcgcaggtt acatgattgt gacccgttac acatgctgac cgattcgcgc
     2881 ccttcatcca ggtcaaatca tcccaaagtg acgacgtttc gcgcggtggc acgcgcccgc
     2941 gtgatatcac acgacacgtt cacacgtaac cccttccggc gatgcaattt tgattttcgc
     3001 tgggtaattt catttgcatg actgccgcgc aagcagacct gcaaatcgat cgtccgagag
     3061 tggccgacgg ggccgccctc tggcggatag ccaaggactc gaaggtcctc gacgtgaact
     3121 cgtcctacag ctatctgctc tggtgccgtg acttcgccgc cacctcggcc gtcgcccgcg
     3181 acgggcacgg ggtgccggtc ggcttcgtga ccggctacgt gcggcccgac cagccggaca
     3241 cgctgctcgt gtggcaggtg gcggtggacg aggcgtaccg tggtcgaaag ctcgcggctt
     3301 cgatgctcga cgggctcgcc gcccggaccc tcgcggagtg cgggacgacg accgtggaga
     3361 ccaccatctc ccccgacaac accgcttccc agcggctgtt cacctcgttc gccgagcgcc
     3421 acggcgccac gctggagcgc gaagtcctct tcgacacgga cgagttcccc gacgggccgc
     3481 acgagcccga ggtcctgtac cgcataggcc ccctcggcgg ctgaccgccc ggcgcccctc
     3541 gccgcccggc ccccagactt cccggccggg accgcaccgg tcccaccgga tccgtacgac
     3601 cttcctctcc caccctcacc ccacgaggag cgattcgtcg tgaccatcac ccagcccgac
     3661 ctcagtgtct tcgagaccgt agagtccgag gtgcgcagct actgccgcgg ctggcccacc
     3721 atcttcgacc gtgcggtcgg cagccgcatg tacgacgagg acgggcacga gtacctggac
     3781 ttcttcgccg gagcgggctc gctcaactac gggcacaaca acgccgtact gaaacgcgct
     3841 ctcatcgact acctggagcg ggacggcgtc acgcacggtc tcgacatgtc gacgaccgcc
     3901 aagcgccgct tcctggagac gttccagaac acgatcctgc gcccgcgcga cctgccgtac
     3961 aaggtcatgt tcccgggccc gacgggcacc aacgccgtgg aagccgcgct gaagctggcg
     4021 cgcaaggtga aggggcgcga gtcgatcgtg tcgttcacca acgccttcca cggcatgtcc
     4081 ctgggctcgc tcgccgtgac cggcaacgcc ttcaagcggg ccggtgccgg tatcccgctg
     4141 gtgcacggca cgcccatgcc gttcgacaac tacttcgacg gcacggtcga ggacttcctg
     4201 tggttcgagc ggctcctgga ggaccagggc tccgggctca acaagccggc cgccgtgatc
     4261 gtggagaccg tgcagggcga gggcggcatc aacgtcgccc ggcccgagtg gctgcgcgcc
     4321 ctgtccgagc tgtgcgaacg ccaggacatg ctgctcatcg tcgacgacat ccagatgggc
     4381 tgcggccgta ccggcgcctt cttctccttc gaggaggcgg gcatcacacc ggacatcgtc
     4441 accgtctcca agtcgatcag cggctacggc ctgcccatgt cgctctgcct gttcaagccg
     4501 gagctggacg tctgggagcc gggcgagcac aacggcacct tccgcggcaa caacccggcc
     4561 ttcgtgacgg cgaccgccac gctggaggcg tactgggccg acgggtcggc gatggagaag
     4621 cagacccgca cccgcggtga gcaggtcgaa cagcacatga tcgccatcac cgaggagaac
     4681 ctcgccgacg tcaaggagta ccggggccgc ggcctggtct ggggcctgga gttccacgac
     4741 aaggaccgtg cgggccgggt cgccaagcgc gccttcgagc tcgggctgct catcgagacg
     4801 tccggtcccg agagcgaggt cgtcaagctg ctgccggcgc tcaccatcac ccccgacgag
     4861 ctggacgagg gcatgaagac cctcgcccgc gccgtgcgcg agaccgcctg acacccccac
     4921 cgcttccggc gccttcgacc gcgcggccga aggcgccggg gaccctcgca cacccttcac
     4981 ctaggaggca tcgcaacacc gtgatcgtcc gttcgttcaa ggagatcgaa ggcaccgacc
     5041 ggcacgtgaa gtcggcgtcc ggcacctggg agagcaagcg catcgtcctc gccaaggaga
     5101 aggtcggctt ctccgtccac gagacgatcc tgtacgcggg cacggagacc tccatgtggt
     5161 acgcgaacca catcgaggcc gtcgtctgca cccagggcga cgccgagttg accgaccgcg
     5221 agacggggaa gacgtaccac atcactccgg gcacgatgta cctcctcaac ggccacgagc
     5281 ggcacacgct caaggtcaag gaggacttcc actgcatctg tgtcttcaac ccgcccgtga
     5341 ccggacggga ggatcacgac gagaacggcg tctacccgct gctcaccgag gaggtgtgag
     5401 tcaccgtgac catcacgacc acgaacatca ccgatctcta tcccacccgc ggcgccaccg
     5461 aggtggccac cccccggcgg gacccggtcg tctggggctc cccggacacc cccggtcccg
     5521 tctcggccgg tgacctgcag tccctggacc gcgacggctt cctcgccatc gaccagctca
     5581 tcgggccgga cgaggtcgac gtctaccggc gggaactgga gcggctcacc tccgatccgg
     5641 cgatccgcgc ggacgagcgc tcgatcgtgg agccgcagtc caaggagatc cggtccgtct
     5701 tcgaggtgca caagatcagc gaggtcttcg cgaacctggt gcgcgacgag cgggtggtcg
     5761 ggcgggcccg gcagatcctc ggctcggacg tctacgtcca ccagtcccgg atcaacgtga
     5821 agcccggctt cggggccagc ggtttctact ggcactcgga cttcgagacc tggcacgccg
     5881 aggacggcct gccgaacatg cggacgatct cggtctcgat cgcgctcacc gagaactacg
     5941 acaccaacgg cggtctgatg atcatgccgg ggtcgcacaa gacgttcctc gggtgcgcgg
     6001 gggccacgcc gaaggacaac tacaagaagt ccctgcagat gcaggacgcg ggcacgccgt
     6061 ccgacgaggc gctgaccaag atggcgtcgg agtacggcat caagctgttc accggcaagg
     6121 ccggctcggc gacctggttc gactgcaact gcatgcacgg ctcgggcgac aacatcacgc
     6181 ccttcccgcg cagcaacgtg ttcatcgtgt tcaacagcgt ggagaacacg gccgtcgagc
     6241 ccttcgcggc gccgatccgg cgaccggact tcatcggcgc gcgggacttc actccggtga
     6301 ggtgacccgc atctgatccc gggcaggagc ctcttcgtgt gggacgggag gctcctgccc
     6361 gatgctgtcc ggggtccgtg cccgcgccgg cccggtcggc tgccccgggc cccttgcggt
     6421 gccggcccgg tcgctgcctc agtccgccag cacgttcagc agccggtcga cgtccgccgg
     6481 ggtgttgtac gcgtggaagg cggcccgcag attgcccgcc cggtccgaga cctgcacgtc
     6541 ggcccggccc aactcgccct gccggtggcc gagtgcgggt acggacacga tcgcggaacc
     6601 cggcgcgggc accggcccgt ggcccaggga ggccagcccc tcgcggaacc ggtcggcgag
     6661 ggccgtgtcg tgggcgtgca cggcgtccac gccgaggtcc gcgatcaggg agagggagtg
     6721 ccgggcgccc gcgtacgaga acagggcggg gctctcgtcg aagcgccgtg cggagtgcgc
     6781 gagttccccg acggggccgt agcagctgtc ccaggggcgc tccccggacg cccacccggc
     6841 gaacagcggc gtcagtccgg cggccgctcc caggtcctcc ggtacgacga ggaaggcgac
     6901 accgcgcggg cagagcagcc acttgaaggc gaccgcggtc acgaagtcga actcccccgc
     6961 ggccaggggc agccacccgc tggactgcga ggcgtcgatc agcgtccgcg ccccgtgcac
     7021 ccgggcggcg tcccgcagcg ccgcgaggcc ggcgatccgc ccgtcggccg actggacgga
     7081 actgaccgcg acgagcgcgg tgcccggccc caccgactcc gcgatgcgct ccagcggcac
     7141 actgcgcacc ttcaggtccc cgcgcatgtg gaaggggttc accagggagc tgaagtcacc
     7201 ctccgcggtg aggacttcgg ctcccgaggg cagcgcggcg gcgacgagcc cgctgaacgt
     7261 ggcgaccgac gcgccggccg cgacccggga cgagggcacc cccgtcagcc gggcgaaggc
     7321 ggaacggctc gcctcgacgt cggcgaacat gtcggacggc tccccggccg ccgccgcctc
     7381 cgccgcgtca cgcatcgcgg cgagggtccg ggcggggagc agaccggtgc tggcggtgtt
     7441 caggtacgtg gtcttcgggt cgaactcggc acggacgagg ttctcgaagc tctccatggc
     7501 accactgtgc ggccacggga cctccccgtc cattgcgtct ttccacgccg ctcccccaag
     7561 cagcacttat ggacaggctc tcacctgggc tctcagctcc ggggcaccgc gcacccgtcc
     7621 gggccgcacg cctcggcgtc gccgtcgccg atcggcttca ggggcgtgcg ctcgccccac
     7681 gcctgcgtca gcgcccgggt gaagacctcc gcgggctggg cgccggagac gccgtacgcc
     7741 cggtcgagca cgaagaacgg cacgccgctc gccccgagct cggcggcctc gcgctcgtcg
     7801 gcgcgcacct cgtcggcgta ggcggtggga tcggcgagca ccgcgcgggc ggtgtccgcg
     7861 tccagtccgg cggcgacggc cagctccacc agccgctcgt cgtcggcgaa gacggaccgc
     7921 tcctccgcga agttggcccg gtagaacgcg tccaggagct tctcctgccg tccgctctcg
     7981 cgggcgaggt gcagcagccg gtgcatgtcg aaggtgctgc cgtggtcgcg gccccgggtg
     8041 cggtagtcca ggccctcggc ggcggcctgc gcgccgaggt tgtcctcccc ggcccgcgcc
     8101 tgcgcctcgc tcatgccgta cttggcggtg agcatcgtca gcacgggctg gacgtcgtcc
     8161 ttggcccgcc cggggtccag ctcgaaggag cggtgcacca cctcgacctc gtcgcggtgc
     8221 gggaaggccg cgagcgcctt ctcgaagcgg gccttgccca cgtagcacca cgggcaggcg
     8281 atgtcgctcc agatctcgac gcgcatgtct cggctcttct ccaggtcgta cggggtccgg
     8341 aggccctctc cgtcccgtac gtgaacgttc aagcagggga gctcattccc cgtccacggc
     8401 gaagcgcagg gacaggtggt ggtcgccggc gcccgggggc tcctccgggt cggggaccca
     8461 gccctggcgg ccgtagaagg cctgggcgcg gcggttgtcg gcgtgcacgt ccaggacggc
     8521 cgtccgcctg ccgtcggcgc gccactgctc cacgcaggcg gtgtgcaggg cggtgccgat
     8581 gcccgaccgc cagtggccgg ggtcgatgtg gaactggaac agcctgaccg tgcccgccgg
     8641 tccgtcctcc ggcacccgga aggaggcgac gccgacgagg tcgccccctg ccacggcgca
     8701 cagcacgtgg ccgtcgggcc gctcgacggc cccgcgccag gcggcgaccc agtcggttcc
     8761 gtcgtcgggc ggcccgtccg ggtagtacgt cgcccgggcc cgggcgtgca gggcggccac
     8821 ggtctcggcc tcggcggaca ggacggtgcg gatcaccggg cttccgggca gacgtgtgtc
     8881 gatcatgtac gggaggacgt gggagccacg ccctccggtt gcctcagccg ccgtcgcgca
     8941 ggtcggccgg aaagcccggc cgcagctcca gacggtcgta cgtcaccacg cacccctccc
     9001 ccgtcggcgc ctgcgcgagg aagccgacca gggccgcgcc cgtctccttc tcgtccccca
     9061 gcgtgaacag ccggacgaag gtccagcgct cgccgtcgag ggaggcgtgg aaggcgaagg
     9121 cccggccgga ccggctgacc ctcagccaca ccgaatcccc gtccacggtg aaggagttgc
     9181 agtcgtcgga gtgcccccgg gtgaccaccg tgcagacggt gggcacgtcc ggggagtact
     9241 ccaggcacag cttggcccag gcccgctcac cgacgtggac gtagagcacc ccggcgtcga
     9301 aggccccctg gaaaccgacg gtgacgcggg cgatcaactg gaagtcgccg tcgggagcgc
     9361 cgagcagccg gggtgcgtcg gaggcgggct ccagtgcctc gccggtcggc ggcacgaacc
     9421 ggtcctgcct cgctccggcc cggccggtga ggacaccgcc gtcgtaggac caggctccgt
     9481 cgggcccgta cgggcggagg gggaagggca gttcggggag ttcgagaagc atggtgcgat
     9541 cctctcaggc ccgggggacg tgccccgggc gggctgcgac ggcgtgcggc cgcgccccgt
     9601 gggcgcgtgc ggccgcgacg ccgccacggc cgccggaggg ccgcgccccc ttgcgggcgc
     9661 ggccgtgtgg cgctagcgct ccagcacccc gttgaaccgg cgggggagcc ccagcgggtt
     9721 gtcgtcccgc agttcgggcg gcagcagcgc ctcgggcgtc ccctgatagg cgaccggccg
     9781 cagccagcgc tcgatcgccg tcccgcccac cgacgtggac gtcgacgtcg tggccgggta
     9841 cgggcccccg tggtgctggg ccgccgccac ggcgacaccg gtcggccagc cgttcaccag
     9901 cacccgcccc gcgagcggcg tcacctcggc gaggagctcg gctccccggc cctcgcccgc
     9961 cgcctcctcg gcggagagct gcacggtcgc cgtgaggttg cccggcagcc gggacagcac
    10021 gccccgcacc tcggcctcgt cctcgtagcg ggccaccacg gtgaccggcc cgaagcactc
    10081 ctccagcagc aggtcgtgct cgccctccgc ggtcagccgc ccggccggca cggtcaggaa
    10141 cccggcgctg acggtgtgct cgccgccggc gcccggagtc accggggcgt ccacgccggg
    10201 cagcgcggcg cgctcggcga cgccggcgac gaagttgtcc cgcatgcggt ggtcgagcag
    10261 cacaccggcg tcggtgtcgc tgaccgcgtc cgtgagcgac ttgaccaggc cgtcaccggc
    10321 ggcgcccgcc ggcaccagga ccaggccggg cttcacgcag aactggccga cgcccagcgt
    10381 catcgagccg gccagcccc
//
