LOCUS       NZ_CP012382            21128 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 706083
            Orig. end                         :: 727211
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="4"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11128)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    complement(69..83)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.34"
                     /tool="antismash"
     gene            355..1257
                     /locus_tag="SAM23877_RS03140"
                     /old_locus_tag="SAM23877_0722"
     CDS             355..1257
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268288.1"
                     /locus_tag="SAM23877_RS03140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0722"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_053126682.1"
                     /sec_met_domain="APH (E-value: 5e-33, bitscore: 113.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSGQTHPDPLRVDGRLVRRLLAGRFPQWSQLPVERFPSGGTVNA
                     MYRLGDDMVVRLPLVEDGAGDVRAEREWLPRLSPLLPTAVPEVLGAGEPAAGYPWPWSV
                     YRWLPGELPEAGALTEPALLAGDLARFVRAMRAVTLRGAPAAYRGGPLATLDEATRAAI
                     EELRGLPEEGVDCDALIAVWEDALRAPEWAGPPVWLHADLMPGNLLVTDGRLSSVIDFG
                     CMGVGDPACDLFPAWNLLPAGARELFREALDVDEATWRRGRARALSQAVIALPDHRDTN
                     PAMAGNARHVVRAVLAETR"
     misc_feature    complement(1475..1490)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.74"
                     /tool="antismash"
     gene            1560..2777
                     /locus_tag="SAM23877_RS03145"
                     /old_locus_tag="SAM23877_0723"
     CDS             1560..2777
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971665.1"
                     /locus_tag="SAM23877_RS03145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0723"
                     /product="alginate lyase family protein"
                     /protein_id="WP_053126684.1"
                     /transl_table=11
                     /translation="MSSASRPRPRRSRAVLLASLTAALVGTLLAGPGATAPRAEAAPAA
                     FTHPGVTVSRNQLDFVRAKVAVGAQPWKGAFDRMTASRYADPNRVPKPRAVVECGSYSN
                     PNIGCTDEREDAIAAYTNALAWYTTREERYARKAIELMDAWSAVIRDHTNSNAPLQTGW
                     AGSSWSKAAEIIKHTYPGSWAGAGRFATMLRDVYLPEVAGGSNSNGNWELTMMEAAVGI
                     SVFLEDKASYDKAMAKFRTRTAAYVYLASDGPLPKTVPSQNLDTRDKIVKYWQGQSTFV
                     TGLTQETCRDFTHTGYGISSLSHIAETSRIQGQDLYGTDVGERLRHALGFHATYEQGAA
                     VPDWLCGGSVHLGLGPVTEVGYNALHNRLGFAMTNTQALTERTRPSGSNNLFVAWETLT
                     HGDNPA"
     gene            complement(2797..3903)
                     /gene="paaE"
                     /locus_tag="SAM23877_RS03150"
                     /old_locus_tag="SAM23877_0724"
     CDS             complement(2797..3903)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="SAM23877_RS03150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0724"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_053126686.1"
                     /transl_table=11
                     /translation="MAPTAPASAPPARVRRRPAFHRLRVAAVERLCADAAAVSFEIPDE
                     LAEEFAFAPGQSLTLRREFDGRDERRSYSICAPVGSLPRIGVRVVPGGLFSSWLVNGVR
                     PGDTVEVMAPTGFFTPDLTGPGHHVLIAAGSGITPMVSIAESVLAADDRSGVTLFYGNR
                     RTDTVMFADELADLKDLHPARFQLAHVLSREPREAEVLSGRLDAGRLAALVDALVDVER
                     ADHWWLCGPQGMVADAQRVLADLGVPADRVHRELFFAEDEPVREVRHEEAGPQGPVSEV
                     VITLDGRSTTSSLSRERTILDGAQRTRPDLPFACKGGVCGTCRALVTDGSADMRRNFAL
                     EAAEVDAGYVLTCQSYPVSEKLTVDYDS"
     gene            complement(3903..4409)
                     /gene="paaD"
                     /locus_tag="SAM23877_RS03155"
                     /old_locus_tag="SAM23877_0725"
     CDS             complement(3903..4409)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="SAM23877_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0725"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_053126688.1"
                     /transl_table=11
                     /translation="MVTALLDAHRARRVAEQVPDPELPMLTLADLGVLRAVEVTGDGTV
                     VASLTPTYSGCPAMAEMRADVAARLREAGYARVEIRTVLDPPWTSDWITESGRRKLTEH
                     GIAPPGAAPRGPVPLVLSPTRPAVPCPRCGSADTEETSRFAATSCKALWRCRACREPFE
                     YVKEI"
     gene            complement(4403..5230)
                     /gene="paaC"
                     /locus_tag="SAM23877_RS03160"
                     /old_locus_tag="SAM23877_0726"
     CDS             complement(4403..5230)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="SAM23877_RS03160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0726"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_053126690.1"
                     /transl_table=11
                     /translation="MSDDHVYLSLAEGHEDDSRWAYGTGFEDPLHGVDTTVPEGVDAVE
                     LAAECVALADDALVSAQRLAEWVTRAPELEEEVALANIGLDLLGQARLLYSRAGQVDGT
                     GRGEDAYAYFRDAADFRNVTLAELPDDDFAFAVVRLLVLSSWRLAHFQRLASHPDPVLA
                     AVAAKGVKELTYHRQYAAEWAVRLGDGTDESHRRTREALERVAPYLGELHAAYDARDEV
                     AEVLRQVTEAAGLPVPVYRPLPGSGRAGEHTEHLAPLLAELQGVARAHPEATW"
     gene            complement(5240..5533)
                     /gene="paaB"
                     /locus_tag="SAM23877_RS03165"
     CDS             complement(5240..5533)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988149.1"
                     /locus_tag="SAM23877_RS03165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_053126692.1"
                     /transl_table=11
                     /translation="MTSDQQGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALTHARDLY
                     TRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPEDVPHI"
     gene            complement(5530..6507)
                     /gene="paaA"
                     /locus_tag="SAM23877_RS03170"
                     /old_locus_tag="SAM23877_0727"
     CDS             complement(5530..6507)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031683.1"
                     /locus_tag="SAM23877_RS03170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0727"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_053126694.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPAGLQEHFDATIAHDQRVEPRDWMPDGYRKTLIR
                     QIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGADRDD
                     LTRRLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAMVRI
                     CKEESFHQRQGYELLMTMMRGTDAQREMVQDAVNRWWWPSLMMFGPPDDASPNSARSMA
                     WKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEETGHHDFGTPDWDELMRVIK
                     GDGPCNDQRMERRRTAHEDGAWVREAATAHAAKQAARARKGAAA"
     misc_feature    6526..6539
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    6647..6662
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.17"
                     /tool="antismash"
     gene            6723..7136
                     /gene="paaI"
                     /locus_tag="SAM23877_RS03175"
     CDS             6723..7136
                     /EC_number="3.1.2.-"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388044.1"
                     /locus_tag="SAM23877_RS03175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /protein_id="WP_053142117.1"
                     /transl_table=11
                     /translation="MFAADEASRRLGIELVGHGPGTAVLRMTVTSAMVNGHGIAHGGYL
                     FLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDLLVAHAEERARFGRSGVYDVSVR
                     RAGEVIAEFRGRSRSVRDGRPLETPDTTTKESR"
     gene            7133..8479
                     /gene="paaK"
                     /locus_tag="SAM23877_RS03180"
                     /old_locus_tag="SAM23877_0728"
     CDS             7133..8479
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (88-352). E-value: 3.9e-20.
                     Score: 63.7. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS03180_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345129.1"
                     /locus_tag="SAM23877_RS03180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0728"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_053126696.1"
                     /sec_met_domain="AMP-binding (E-value: 7.7e-24, bitscore:
                     82.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTGTAPAPRRGEPLPRHLLDDAEHLSREQLQELQLDRLRT
                     TLRHAYENVELYRKKFDAAGVKPDDCRSLADLSRFPFTTKADLRDTYPFGMFAVPMADV
                     RRVHASSGTTGRPTVVGYTDNDLSMWADVVARSLRAAGGRPGHKVHISYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIRDFRPEIIMVTPSYMLTLLDEFERQGVDPRST
                     SLEVGVFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECVETKDGLHVWEDH
                     FYPEVVDPLTDAVLGEGEEGEVVFTSLTKEALPIVRYRTRDLSRLLPGTARPAFRRMQK
                     VTGRCDDMIILRGVNVFPTQIEEIVLRTPGVSPHFQIRLTEHGRMDHMVVRVEARPDAG
                     PERREAAARAIGQGVKDGVGVTVEVEIVDPETLERSLGKLRRVTDLRGT"
     aSDomain        7397..8188
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS03180_AMP-binding.1"
                     /evalue="3.90E-20"
                     /label="SAM23877_RS03180_AMP-binding.1"
                     /locus_tag="SAM23877_RS03180"
                     /protein_end="352"
                     /protein_start="88"
                     /score="63.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RDTYPFGMFAVPMADVRRVHASSGTTGRPTVVGYTDNDLSMWADV
                     VARSLRAAGGRPGHKVHISYGYGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIRD
                     FRPEIIMVTPSYMLTLLDEFERQGVDPRSTSLEVGVFGAEPWTEEMRREIEERMDIHAV
                     DIYGLSEVIGPGVAQECVETKDGLHVWEDHFYPEVVDPLTDAVLGEGEEGEVVFTSLTK
                     EALPIVRYRTRDLSRLLPGTARPAFRRMQKVTGRCDDMIILR"
     CDS_motif       8156..8218
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAM23877_RS03180_0001"
                     /evalue="2.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="SAM23877_RS03180"
                     /protein_end="362"
                     /protein_start="341"
                     /score="13.8"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQIE"
     gene            8607..9905
                     /locus_tag="SAM23877_RS03185"
                     /old_locus_tag="SAM23877_0729"
     CDS             8607..9905
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="SAM23877_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0729"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_053126698.1"
                     /sec_met_domain="FMO-like (E-value: 3.3e-81, bitscore:
                     272.0, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-08, bitscore:
                     33.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAVAHALKERGIGFVCLEKAPDVGGIWRRPGAG
                     ERGPGYLSLHLNTAKQLTGYTGWPMPDSYPLYPRHDQVAAYLRSFAERAGVLDHVELRT
                     EVVSVRRDADGMWSVVSRDAHGAVAARRFEQVIVASGHHTDPALPDPLPAGADSFTGRI
                     LHSLDYHDGAGFAGRRVVVVGLGASAVDIAADLSRHAAQTVLSVRRGLHIVPKQLFGMS
                     VDEIAEAPWWNEMSFAERREWVEQALLVARGRLADYGLPEPDHPVFSSAVTLSDEILSR
                     IRHGAVTPKPAIASFDGDRVVFTDGTSTAADAVVYCTGFHMTFPFLPAGCPVAADGSVE
                     LYRRVVPADLPGLYFVGLVRPVGAITRLVEAQARWVARIIDGAATLPPADEMREEIGTH
                     LAAIVQRYGRTRGASIQVDVGPYLAEFRESLAV"
     gene            complement(10001..11128)
                     /locus_tag="SAM23877_RS03190"
                     /old_locus_tag="SAM23877_0730"
     CDS             complement(10001..11128)
                     /EC_number="2.5.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388029.1"
                     /locus_tag="SAM23877_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0730"
                     /product="DMATS family aromatic prenyltransferase"
                     /protein_id="WP_053126701.1"
                     /sec_met_domain="indole_PTase (E-value: 5.6e-142, bitscore:
                     471.6, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVRTGAEPGGAPTLGALTSGQLRRLGAVAGLSEADVETYARVL
                     TDALGPVAARPLHLPPPTRTFLSDDHTPVEFSFSLQPDAAPALRVLLEPGCGADSLALN
                     GRAGLETIRGMARRWNFTTAPLDEVEDLFLPPAPQGPLALWCALELRPGGVPKVKVYLN
                     PAANGAERSAATVREALHRLGHRRAFDSLPRGTGHPFLALDLGDWEDPRVKVYVRHDNL
                     TARQAGLLSREGTGPGPAAVEGFFRAAAGVGPDRSGLDRRPGLTCHSFTDTGSGRPSGF
                     TLHIPVRDYARHDGEALERAASVLRHHAMDEAVLPRAFAALTQRRPEDGVGLIAYLALA
                     HQQGRPPRVTAYLSSEAYAVRAPAVAAVRRPVAVR"
     misc_feature    complement(10889..10891)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11124..11139
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(11254..11267)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            complement(11336..12685)
                     /locus_tag="SAM23877_RS03195"
                     /old_locus_tag="SAM23877_0731"
     CDS             complement(11336..12685)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324216.1"
                     /locus_tag="SAM23877_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0731"
                     /product="cytochrome P450"
                     /protein_id="WP_053126703.1"
                     /transl_table=11
                     /translation="MNAHDTFPVPPPGCPAHGSGARVPLHGPEFAADPQAFYEYLRHYG
                     VAAPVELAPGVEATLVTDYSAALQLLQDSGSFRKDARRWRAFNEGKVGPDSPVAPLLAY
                     RPNCMFADGADHLRLRQAVTDSMARVDTRRLTRSTEQISGYLISQFGGRGSADLLGDYA
                     RQLPLFVFNELFGCPADIGDRVLFGISGMFDGINADKATAVLFQAVGELVALKRSKPGD
                     DVTSWLMRHEADLSDEEMVHQLALLLGAGAEPLRNLIGNTLHRLLTHERYAREGGLIDE
                     ALDDTLWENPPMANYAPHYPAADTELAGQQLHSGDLVLVSFAAANTGPALKASRQAGSN
                     RAHLAWSAGPHACPSKEPARHITVTAIEHLFNELPDVELAVPEDSLTWRPGPFNRALAT
                     LPARFTPARTGRRSAAQPDPRAPEREQAPSPDRPAERGGMWSQFLNWLTR"
     misc_feature    complement(12678..12689)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            complement(12701..13294)
                     /locus_tag="SAM23877_RS03200"
                     /old_locus_tag="SAM23877_0732"
     CDS             complement(12701..13294)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="SAM23877_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0732"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_053126705.1"
                     /transl_table=11
                     /translation="MASAPSLDEQDYVRGGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAESVDDLKGVQGKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEQYGLDYAIAVNHFDGAPLRDERALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRYLLDRTR"
     gene            complement(13269..13646)
                     /locus_tag="SAM23877_RS03205"
                     /old_locus_tag="SAM23877_0733"
     CDS             complement(13269..13646)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="SAM23877_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0733"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_053126706.1"
                     /transl_table=11
                     /translation="MTGHDGWEPEAAELVRPYVITKGRGLPDEEHLSLITLVTASAGHT
                     QRPTRLSPEEQSLLDLCSAGYLSVAEIAGHTHFPLGVVRILLASLMEGGHLMTRPPVAR
                     ARLADKEILEEVLNGLRAKFG"
     misc_feature    complement(13605..13607)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13643..14044)
                     /locus_tag="SAM23877_RS03210"
                     /old_locus_tag="SAM23877_0734"
     CDS             complement(13643..14044)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="SAM23877_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0734"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_053126708.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFDKDDADRV
                     AAAMSGVQSLSRTLAFFCEDPHQAWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVAQLGKRLTTPPRENLGTRS"
     gene            complement(14041..15213)
                     /locus_tag="SAM23877_RS03215"
                     /old_locus_tag="SAM23877_0735"
     CDS             complement(14041..15213)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="SAM23877_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0735"
                     /product="ATP-binding protein"
                     /protein_id="WP_053126709.1"
                     /transl_table=11
                     /translation="MTEYLGNPLLWVLVVALVAAAALIGRQRRAARSLRQEIQGLRDHY
                     TELENDYGKSVLAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLTRLQTKYGDSALLQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGGRRDTASVYDVVRSAQGRIRHFRRVEILSQVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINIRTVPKGICVVVDDAGVGMSDEER
                     ARADKLLATERASGVAGLGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     ELLTAMPEKKAPSPAAHTVARPGPDGGPEAAIAPSRTSDGLPRRRRKRPMAIVPGSAAT
                     PRSAGRSDSEQAQIMAAFQRGTQTGRVTRPEDPDRTSRTPGASREGHEDS"
     gene            15545..16297
                     /locus_tag="SAM23877_RS03220"
                     /old_locus_tag="SAM23877_0737"
     CDS             15545..16297
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324211.1"
                     /locus_tag="SAM23877_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0737"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_174532278.1"
                     /transl_table=11
                     /translation="MAAVFTAGFGAGAINSVVGSGTLITFPVLLATGLSPVTATVSNAL
                     GLIPGSISGAVGYRKELSGQRRRVLKLSAGALLGGLAGATLLLSLPADAFETIVPVLVG
                     LALLLVAFQPRIGRLVQRRRERTGTSPRRDGGPLLFTGLTLASVYGGYFAAAQGIIYLS
                     LMGMLLDESLQRLNAVKNVLSAVVNSVAALFFLFAADFDWTAVGLIAAGSALGGYAGAK
                     VGRRFSPVVLRTLVVTVGTVALVQLLLR"
     gene            16642..17370
                     /locus_tag="SAM23877_RS03225"
                     /old_locus_tag="SAM23877_0738"
     CDS             16642..17370
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016328090.1"
                     /locus_tag="SAM23877_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0738"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_053126713.1"
                     /transl_table=11
                     /translation="MRISRPLPTLVAALLAALLSALALAPSTSAAEPRPGDGGPQPIIG
                     GGYAQNAPWAARLFSNGTQTCTSTIISPTWILTAKHCVTGGGLSFRIGSLDQQSGGTVA
                     NGVQTVAHSSSDLALVRLDRSVSASYAPLGQPGTVRVGQTVQVYGWGATSRCGSEINCQ
                     SRYLKVANVSVTQGCRDAYNGSAICARAVDGITAGGDSGGPMTAGGIQVGVASTSDRQS
                     TTAYTNVTAYRSWIQSVAGV"
     gene            17568..18407
                     /locus_tag="SAM23877_RS03230"
                     /old_locus_tag="SAM23877_0739"
     CDS             17568..18407
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971683.1"
                     /locus_tag="SAM23877_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0739"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_053126715.1"
                     /transl_table=11
                     /translation="MAGQTAGSPENERETAVLRLQDVTVRRLTTDQLILDGIDWTVLPG
                     EHWALLGANGAGKTTVLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVTSAQRV
                     PPELTAHTVVLTGHSGTVQPLWRTYDDEVRLRAHDLLTELGVKELADRPYGVCSGGQRA
                     RVLIARALMADPALLLLDEPFNALDLPSREDLVEAMHHLADSRPRLATVTVTHHLEELS
                     PAVSHALLLREGRVLSRGAVDGVLTDALLTACFGRDITVMRRDGRWSAYSGLRGHGR"
     gene            19121..20113
                     /locus_tag="SAM23877_RS03235"
                     /old_locus_tag="SAM23877_0740"
     CDS             19121..20113
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329486.1"
                     /locus_tag="SAM23877_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0740"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_244902912.1"
                     /transl_table=11
                     /translation="MAPPQSTASSKDVSGEKIPATVSHDTTLTVGAPDLKVALELSGQI
                     DDLPFKVKWANMSGGPQCSEAFRAGALDVCSAADIPSINAHWTGLDTKLVAVKFRSDPI
                     RNPIYELGTAPGSGIRKLSDLRGKKIAYSPGQAQGALVLRILKKAGLTQQDVELVELAS
                     TGDVYPTALGNRQVDAAPIADVNIKRYLAHYGKEGGATVKHGLRDDPAHLWALTESVAD
                     TGKSSAVRELVKFWARAQIWIDKHPKEWVAGYYVEDQGLSRADGEYLVRRVGHPDLPAD
                     WTDAVRRQQQTIDLLAEEQDREPFKADLLFDRRYETVAAEAVAGEGTPS"
     gene            20110..20967
                     /locus_tag="SAM23877_RS03240"
                     /old_locus_tag="SAM23877_0741"
     CDS             20110..20967
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329485.1"
                     /locus_tag="SAM23877_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_0741"
                     /product="ABC transporter permease"
                     /protein_id="WP_053126718.1"
                     /transl_table=11
                     /translation="MSTTLLDEQAARATKARTLAVRPPRPRRRRPGPGRPLPYGWAIGP
                     VLLLVLWTAGTGLGLVDVRSLPAPWTIADTAGQLIDNGKLPSHLATSAQRALLGLLFGV
                     AAGLLLALVAGLSRVGEAVIDGPVQIKRAIPSLALIPLLILWFGIGETMKVITIALGVF
                     VPVYIHTHNGLRAIDSRYAELAETVRLGRLAFVRHVVLPGALPGFLLGMRFAVTGAWLA
                     LVVVEQVNATSGIGYMMELARTYGQTDVIIVGLVVYGLLGLVSDALVRLVERRALSWRR
                     TLAG"
ORIGIN
        1 gatcgtctcc aacgaggtgc tgcagaactt ccccgcggac cagctccgcc agcggttcaa
       61 ccagcacgtg gaccggctcg tcgccaactt cgagctcggc aagagcgagg cgctgcaggt
      121 gatcgccaag gccgccaaga agcccgcgga ggcccgcgcg gtcatccaga ccggcatggt
      181 catcgccggc gccgacgggg tcttcgagcc gtcggagcag tacgcgatcc gcgaggcctg
      241 caccgccctg ggcgtgccgc cctcggagtt cggcgtctga gcccgggcgc cttcgcgtcc
      301 gccggacggg aaagcgtttg acggccgtcc gcgtcaaggg atcggatgag gcccatgact
      361 tctgggcaga cgcatccgga cccgctccgc gtggacggcc gtctcgttcg gcgcctgctc
      421 gccggccggt tcccgcagtg gtcgcaactg ccggtcgagc gcttcccgtc cggtggcacg
      481 gtcaacgcga tgtaccggct cggcgacgac atggtcgtcc ggctgccgct cgtcgaggat
      541 ggagccgggg acgtgagggc ggagcgggag tggctgcccc gcctgtcgcc cctgctgccc
      601 accgccgttc ccgaggtgct cggggccggt gagcccgccg cggggtatcc gtggccgtgg
      661 tcggtgtacc ggtggctgcc cggtgagctg cccgaggccg gagcgctcac cgagcccgcg
      721 ctgctggccg gggatctggc ccggttcgta cgggcgatgc gggccgtcac cctgcggggc
      781 gcgccggccg cctatcgcgg cggcccgctc gccacgctcg acgaggcgac ccgggccgcg
      841 atcgaggaac tgcgcggtct cccggaggaa ggcgtcgact gcgacgccct gatcgccgtg
      901 tgggaggacg cgctgcgagc cccggagtgg gccggaccgc cggtctggct gcacgccgac
      961 ctgatgccgg gcaacctgct ggtgaccgac ggcaggttgt cctcggtgat cgacttcggc
     1021 tgcatgggcg tgggcgaccc ggcctgcgac ctcttcccgg cctggaacct gctgccggcc
     1081 ggggcgcggg agctcttccg tgaggccctc gacgtggacg aggcgacctg gcggcgcggc
     1141 cgggcacggg ccctctccca ggccgtcatc gcgctccccg accaccggga caccaacccc
     1201 gcgatggccg gcaacgcacg ccacgtcgtc cgggcggtgc tggcggagac ccgctgagca
     1261 gacgcctcgt cagtcgggag cggttcctgc ggggcgtccc ctgggaagcc actgcccagg
     1321 acgccccagg acgcgatccc cacaccgtcg atcccgcccc gcgcccgttc ctgtgcggtg
     1381 gtcacggcgg gccgacgcag tccgccgggc cggccgtacc cgcgcaccgt gcacgacgcc
     1441 gtggtcgacc cgttgcgcgg actcttgacg ccccattggt ctctacctat cgtcaccgac
     1501 cagtcgagcg ttcagaacag gacgtaacgt tcacatacac gaacggacgg accccccaca
     1561 tgtcctctgc ctcccgacct cgcccccgca gatcccgcgc cgtcctcctc gcgagcctca
     1621 ccgccgcact ggtcggcacc ctcctcgccg gccccggagc gaccgctccc cgggccgaag
     1681 ccgcgcccgc cgcgttcacc catccgggcg tcacggtctc ccggaaccaa ctcgacttcg
     1741 tccgcgccaa ggtcgccgtc ggggcccagc cctggaaggg cgccttcgac cggatgacgg
     1801 cgagcaggta cgccgatccg aaccgcgtcc cgaagccgcg ggcggtggtg gagtgcggct
     1861 cctactcgaa cccgaacatc ggctgcaccg acgagcgcga ggacgcgatc gcggcctaca
     1921 ccaacgccct ggcctggtac acgacccgcg aggagcggta cgcgcgcaag gccatcgagc
     1981 tgatggacgc ctggtccgcc gtgatcaggg accacaccaa cagcaacgct ccgctgcaga
     2041 ccggatgggc cggctcctcc tggtccaagg cggcggagat catcaagcac acctacccgg
     2101 gctcatgggc cggcgccggc cgcttcgcca ccatgctccg ggacgtctac ctgcccgagg
     2161 tcgcaggcgg ctcgaactcc aacggcaact gggaactcac gatgatggag gccgccgtgg
     2221 gcatctccgt cttcctggag gacaaggcct cctacgacaa ggcgatggcc aagttccgca
     2281 cccgcacggc cgcctacgtg tacctggcct ccgacgggcc cctgccgaag accgtgccga
     2341 gccagaacct cgacacccgg gacaagatcg tcaagtactg gcagggccag tccaccttcg
     2401 tcaccgggct cacccaggag acctgccggg acttcaccca caccggatac ggcatctcct
     2461 ccctctcgca catcgccgag accagccgca tccaggggca ggacctgtac ggcaccgacg
     2521 tgggcgagcg gctgcggcac gcgctcggct tccacgcgac gtacgagcag ggcgctgccg
     2581 tgccggactg gctgtgcggc ggttcggtcc acctcggcct ggggccggtc accgaggtcg
     2641 gctacaacgc cctgcacaac cgcctcggct tcgccatgac caacacccag gccctgaccg
     2701 agcgcacccg cccctccggc tcgaacaacc tcttcgtcgc ctgggagacc ctgacccacg
     2761 gcgacaaccc cgcctgagcc ccgcggcgcc gtcgcctcag ctgtcgtagt ccacggtcag
     2821 cttctcggag accggatacg actggcaggt caggacgtag ccggcgtcga cctcggcggc
     2881 ttccagggcg aagttgcggc gcatgtccgc actgccgtcc gtgaccaggg cccggcaggt
     2941 gccgcagacg ccgcccttgc aggcgaaggg gaggtcgggc ctggtccgct gcgcaccgtc
     3001 gaggatggtc cgctcccggg acagggagga ggtcgtggag cggccgtcca gggtgatgac
     3061 gacctcgctg acgggcccct gcgggccggc ctcctcgtgg cgcacctccc gcacgggctc
     3121 gtcctcggcg aagaacagct cgcggtggac gcggtccgcc gggactccga ggtcggccag
     3181 gacccgctgg gcgtcggcga ccatgccctg ggggccgcac agccaccagt ggtccgcacg
     3241 ctccacgtcc accagcgcgt ccacgagcgc cgcgagccgt ccggcgtcga ggcggccgga
     3301 gagcacctcg gcctcgcggg gctcgcggga gagcacgtgg gcgagctgga agcgggccgg
     3361 gtggaggtcc ttgaggtcgg ccagctcgtc ggcgaacatc accgtgtcgg tgcggcggtt
     3421 gccgtagaac agcgtgacgc cggagcggtc gtcggcggcc agcaccgact cggcgatcga
     3481 caccatgggc gtgatgcccg agccggccgc gatcagcaca tggtggcccg ggccggtcag
     3541 gtcgggcgtg aagaagccgg tgggggccat cacctcgacc gtgtcacccg gacgcacccc
     3601 gttcaccagc cacgacgaga acaggccccc cggcaccacg cggacaccga tccgcgggag
     3661 cgagccgacc ggtgcgcaga tcgagtacga gcggcgctcg tcccggccgt cgaactcgcg
     3721 ccgcagggtg agcgactgac cgggcgcgaa ggcgaactcc tcggccagtt cgtccgggat
     3781 ctcgaagctc acggccgccg cgtcggcaca cagccgctcg acggcggcga cccgcagacg
     3841 gtggaaggcc gggcgccggc ggacgcgcgc cggcggcgcc gaggcggggg cggtcggggc
     3901 catcagatct ccttgacgta ctcgaacggc tcacggcagg cccggcagcg ccacagcgcc
     3961 ttgcaggacg tggcggcgaa gcgggaggtc tcctcggtgt ccgccgaacc gcaccgggga
     4021 cagggcaccg cgggccgggt gggcgacagc accaggggga ccgggccgcg gggtgcggca
     4081 ccgggtgggg cgatgccgtg ttcggtgagc ttgcggcggc cggactcggt gatccagtcg
     4141 ctggtccagg gcggatcgag gaccgtacgg atctccacgc gcgcgtaccc cgcctcccgc
     4201 agccgcgcgg cgacgtccgc ccgcatctcg gccatggccg ggcatcccga gtaggtcggg
     4261 gtcaggctcg ccaccacggt gccgtcgccg gtcacctcga cggcgcgcag cacaccgagg
     4321 tcggccaggg tcagcatggg cagctccggg tccggcacct gctcggccac gcgccgggcg
     4381 cggtgggcgt ccaggagggc ggtcaccatg tcgcctccgg gtgggcacgg gcgacgccct
     4441 gcaactcggc gaggagcggc gcgagatgtt cggtgtgctc accggcacgg cccgatccgg
     4501 gcaacggccg gtacaccggc acgggcagtc cggccgcctc ggtgacctgg cgcagcacct
     4561 cggcgacctc gtcccgtgcg tcgtacgccg cgtgcagctc gccgaggtac ggggcgaccc
     4621 gctccagcgc ctcgcgcgtc ctgcggtgcg actcgtccgt gccgtcgccg aggcgcacgg
     4681 cccattcggc ggcgtactgc cggtggtacg tcagttcctt gacgcccttg gccgcgaccg
     4741 ccgcgagaac cggatcgggg tgggacgcca gccgctggaa gtgggcgaga cgccagctgg
     4801 agaggaccag caggcgcacg acggcgaacg cgaagtcgtc gtcgggcagc tcggccaggg
     4861 tgacgttgcg gaagtcggcg gcgtccctga agtaggcgta ggcgtcctcg ccgcggccgg
     4921 tgccgtcgac ctggcccgcg cgcgagtaga gcaggcgggc ctggccgagg aggtcgaggc
     4981 cgatgttggc cagcgccacc tcctcctcca gttccggggc ccgggtgacc cactcggcga
     5041 gccgttgcgc cgagaccagg gcgtcgtcgg cgagtgccac gcactccgcg gccagctcga
     5101 ccgcgtcgac accctcgggc acggtggtgt cgacgccgtg cagcggatcc tcgaagccgg
     5161 tgccgtaggc ccagcggctg tcgtcctcgt gcccctcggc caggctcagg tagacgtggt
     5221 cgtcactcat gccctgctcc tagatgtggg ggacgtcttc ggggatgtcg tagaaggtcg
     5281 ggtggcggta gaccttgtcg gcgctggggg cgaagaacgg gtccttctcg tcgcgggtgg
     5341 aggcggcgat gtgctcggag cgcacgaccc agatgctcac gccctcgttg cgccgggtgt
     5401 agaggtcccg ggcgtgggtg agggccatgg cgtcgtcggc ggcgtgcagc gagccgacgt
     5461 ggacgtggtt gaggccccgc ttgccgcgca cgaacacctc gtagagcggc cagccctgct
     5521 ggtcggaggt catgccgccg ctcccttcct cgcgcgggcg gcctgcttgg cggcgtgggc
     5581 ggtggccgcc tcgcgcaccc aggcgccgtc ctcgtgggcg gtccgccgcc gctccatccg
     5641 ctggtcgttg cacgggccgt cgcccttgat gacgcgcatc agctcgtccc agtcgggggt
     5701 gccgaagtcg tggtgtccgg tctcctcgtt ccagcgcagc tccgggtccg gcagggtgac
     5761 accgagcttc tcggcctgcg ggacggtcat gtcgacgaag cgtcggcgca gttcgtcgtt
     5821 gctgtgccgc ttgatcttcc aggccatcga ccgcgcggag ttgggcgagg cgtcgtcggg
     5881 cgggccgaac atcatgaggg agggccacca ccagcggttc acggcgtcct ggaccatctc
     5941 gcgctgggcg tcggtgccgc gcatcatcgt catcagcagc tcgtagccct gccgctggtg
     6001 gaaggactcc tccttgcaga tgcgcaccat cgcgcgcgcg tacggaccgt aggagctgcg
     6061 gcacagcggg acctggttgc agatcgccgc gccgtccacg aaccacccga tcacgccgac
     6121 gtccgcgaag ctcagcgtcg ggtagttgaa gatcgacgag tacttctggc gtccctcgat
     6181 cagccgccgg gtgaggtcgt cgcggtccgc gccgagcgtc tcggccgccg agtagaggta
     6241 gagcccgtgg ccggcctcgt cctggacctt ggcgaacagg atcgccttgc ggcgcaggga
     6301 cggcgcccgc gtgatccact cgccctccgg ctgcatgccg atgatctccg agtgcgcgtg
     6361 ctgggcgatc tgccggatca gcgtcttccg gtagccgtcc ggcatccagt cgcgcggctc
     6421 gacgcgctgg tcgtgcgcga tcgtcgcgtc gaagtgctcc tgcagccctg cggggggcgg
     6481 tgcctcggcg gcgtgtgtcg tggtcatcgt caccagcttc ccaaccgacc attcgttcgg
     6541 tatcagtgtg acgcctttcc gggcgccggg caagaccccg gcgcacccgt cgcacacact
     6601 cttgacagtg ccgccccgcg gctggattac tgggccgtgc gaggagctga ccgaatggtc
     6661 ggtcgggaaa cgaggtggtg ggaaaggtgt cgcggaccac ggagccggcg cccacggagg
     6721 tcatgttcgc cgcggacgag gcgtcccggc ggctgggtat cgagctggtc gggcacggcc
     6781 ctggcacggc cgtgctccgt atgaccgtga cctcggcgat ggtgaacggg cacggcatcg
     6841 cccacggcgg ctacctgttc ctgctggccg acaccgcctt cgcgtgcgcg tgcaacagcc
     6901 acggccccgt gaccgtcgcg gcgggcgccg acatcgtgtt cgtcgcgccg gcccgcgagg
     6961 gcgatctgct cgtggcgcac gccgaggaac gcgcccggtt cggccgcagc ggcgtgtacg
     7021 acgtgagcgt acggcgcgcg ggcgaagtga tcgcggagtt ccgcggacgc agtcgcagcg
     7081 tccgggacgg ccggccgctc gagacgccgg acacgacgac gaaggagtcg cgatgagcag
     7141 cgagccgacg accgggacgg ccccggcacc ccgccgggga gagcccctcc cccgccacct
     7201 gctggacgac gccgagcacc tctcccggga gcagctccag gagctccagc tggaccgact
     7261 gcgcacgaca ctgcggcacg cctacgagaa cgtggagctc taccgcaaga agttcgacgc
     7321 cgccggggtg aagcccgacg actgccgcag cctggcggac ctgtcccggt tccccttcac
     7381 caccaaggcc gacctgcggg acacgtaccc cttcggcatg ttcgccgtcc cgatggccga
     7441 cgtgcggcgc gtccacgcct ccagcggcac caccggccgc cccaccgtgg tcgggtacac
     7501 cgacaacgac ctgtccatgt gggcggacgt cgtcgcccgc tccctgcgcg ccgcgggcgg
     7561 ccgtcccggc cacaaggtgc acatctccta cggctacggc ctgttcaccg gcggcctcgg
     7621 cgcccactac ggcgccgaac gcgccgggtg cacggtgatc ccggcctccg gcggcatgac
     7681 ggcgcggcag gtgcagatca tccgggactt ccggcccgag atcatcatgg tcaccccgtc
     7741 ctacatgctc accctgctcg acgagttcga gcggcagggc gtcgacccgc gctccacctc
     7801 cctggaggtc ggcgtcttcg gggccgagcc gtggaccgag gagatgcgcc gcgagatcga
     7861 ggagcgcatg gacatccacg ccgtcgacat atacggcctg tcggaggtga tcggcccggg
     7921 cgtggcgcag gagtgcgtgg agaccaagga cgggctgcac gtgtgggagg accacttcta
     7981 cccggaggtg gtcgacccgc tcacggacgc cgtgctgggc gagggcgagg agggcgaggt
     8041 cgtcttcacc tccctcacca aggaggcgct gccgatcgtc cgctaccgca cgcgcgacct
     8101 gtcccggctg ctgccgggca ccgcccggcc cgccttccgc cggatgcaga aggtcaccgg
     8161 ccgctgcgac gacatgatca tcctgcgcgg ggtgaacgtc ttccccaccc agatcgagga
     8221 gatcgtgctg cgcacgcccg gcgtctcccc gcacttccag atccggctca ccgagcacgg
     8281 ccgcatggac cacatggtgg tgcgggtcga ggctcgcccc gacgcggggc cggagcggcg
     8341 ggaggccgcc gccagggcga tcggccaggg tgtcaaggac ggtgtggggg tcaccgtcga
     8401 ggtggagatc gtcgacccgg agacgctgga gcgctccctc ggcaagctcc gccgggtcac
     8461 ggacctgcgc gggacctgag cgccgcacgg ggcgaaacgt gaggacggac acgtccgttc
     8521 acccctcgcg ctggtgtgcg gggggacacg gatgggcagt gaatgcatga tcgggggagg
     8581 ttgagtacgt cctgggggga aattccgtgc gtgtgtgcgt gatcggtgcc ggcctgtccg
     8641 gactggcggt ggcccacgcc ctcaaggagc gcggcatcgg cttcgtctgc ctggagaagg
     8701 cgcccgacgt cggcgggatc tggcgtcggc cgggggccgg cgagcgcgga cccggatacc
     8761 tgtccctgca cctcaacacc gccaagcagc tgacgggtta caccggctgg ccgatgccgg
     8821 attcctaccc gctctacccc cggcacgacc aggtcgccgc ctacctgcgg tccttcgccg
     8881 aacgggccgg cgtgctggac cacgtcgagc tgcggaccga ggtggtgtcc gtgcggcgcg
     8941 acgcggacgg catgtggtcg gtggtcagcc gggacgcgca cggcgcggtg gcggcccggc
     9001 ggttcgagca ggtgatcgtc gcctcggggc accacaccga ccccgcgctg cccgacccgc
     9061 ttccggcggg cgccgactcc ttcaccggac ggatcctgca ctccctcgac taccacgacg
     9121 gggccggctt cgctggacgc cgcgtcgtcg tggtgggcct gggcgcctcg gcggtggaca
     9181 tcgccgcgga cctctcccgg cacgccgcgc agaccgtgct gtcggtgcgc cgagggctgc
     9241 acatcgtgcc caaacagctg ttcggcatgt cggtcgacga gatcgccgaa gccccctggt
     9301 ggaacgagat gtccttcgcc gagcgacgcg agtgggtgga gcaggcgctg ctcgtcgcgc
     9361 gcggcagact ggccgactac gggctgcccg agcccgacca tccggtcttc tcctcggccg
     9421 tgaccctctc ggacgagatc ctcagccgga tacgccacgg cgccgtcacc cccaagcccg
     9481 cgatcgcctc gttcgacggc gaccgcgtcg tgttcaccga cggcacctcc acggccgcgg
     9541 acgcggtcgt ctactgcacc ggcttccaca tgaccttccc cttcctgccc gccggttgcc
     9601 cggtggcggc ggacggttcg gtcgagctgt accggcgggt ggtccccgcc gacctgccgg
     9661 gcctgtactt cgtcggactg gtcaggcccg tgggcgcgat cacccggctg gtggaggccc
     9721 aggcgcggtg ggtggcgcgg atcatcgacg gcgcggccac actgcccccg gccgacgaga
     9781 tgcgcgagga gatcggcacc cacctcgccg ccatcgtcca gcgctacggc cgcacccggg
     9841 gcgcctccat ccaggtcgac gtgggcccct acctggcgga gttccgggag tcgctggccg
     9901 tgtagccgta ggcccggcgc cctctccggc gccgggtcgc ccccgcgccc agggctcccg
     9961 gtgggcgcca ccgggagcct gcggtgtcgg ggcggtccgc tcagcgcacc gccaccgggc
    10021 ggcggacagc cgccacggcc ggcgccctga ccgcgtacgc ctccgaggag aggtacgccg
    10081 tcacccgcgg cggccggccc tgctgatggg ccagcgccag gtaggcgatc agcccgaccc
    10141 cgtcctccgg ccgccgctgg gtgagggcgg cgaaggcccg gggcagcacc gcctcgtcca
    10201 tcgcgtggtg gcgcaacacg ctcgccgcgc gctccagcgc ctcaccgtcg tgccgggcgt
    10261 agtccctgac cgggatgtgc agggtgaatc cgctcggccg cccggacccg gtgtcggtga
    10321 aggagtgaca ggtcaggccg ggccgcctgt cgagccccga ccggtcgggg ccgacgcccg
    10381 cggccgccct gaagaaaccc tcgaccgccg cgggaccggg gcccgtcccc tcgcgcgaca
    10441 acagacccgc ctggcgggcc gtgaggttgt cgtggcgcac gtagaccttg acccgggggt
    10501 cctcccagtc ccccaggtcc agggcgagga acggatgacc ggtgccgcgc ggcaggctgt
    10561 cgaaggctcg ccggtggccc agccggtgca gggcctcgcg caccgttgcg gcggaacgtt
    10621 ccgccccgtt cgcggccggg ttcaggtaga ccttgacctt gggcacgccg ccgggcctga
    10681 gctccagggc gcaccacagg gccaggggac cctgcggagc gggcggcagg aacaggtcct
    10741 cgacctcgtc gagcggggcg gtggtgaagt tccagcgacg cgccatcccc cggatggtct
    10801 cgagtccggc acggccgttg agggccaggc tgtctgcgcc gcagcccggt tccaggagca
    10861 cccgcagggc gggggccgcg tccggctgta aggagaacga gaactcgacg ggggtgtggt
    10921 cgtcggacag gaaggtgcgg gtgggaggcg gcaggtgcag cggtcgcgcg gccaccgggc
    10981 ccagtgcgtc ggtcaggact cgggcgtagg tctcgacgtc ggcttcggag aggccggcga
    11041 ccgcgccgag tcttcgcaac tggccgctcg tgagggcgcc gagggtcggt gcgccccccg
    11101 gttccgcgcc ggtccgtacg gtggtcaccg gcccgtccct cgcccgggcc gcacaaagag
    11161 atacccgcct ggggaggcgg gtatcggtga gagcggcggt ggcagagcgg cgttcgtgga
    11221 tatgtggtcc acgacacctc cttctcctcg tgagcaactt gaatgccgcg ttgctcacta
    11281 cccgtgccgt tgatccttca tgcgaaaggg acaggttggg aggatgttgc gcgtgtcacc
    11341 gtgtgagcca gttgaggaac tgactccaca tgcctcctcg ttcggccggt cggtccgggc
    11401 tcggcgcctg ttcccgttca ggtgcccggg ggtccggctg cgctgcggag cggcgtccgg
    11461 tccgcgccgg cgtgaagcgg gccggcaggg tggccagagc ccggttgaag gggcccggcc
    11521 gccaggtcag gctgtcctcg gggacggcga gttcgacgtc gggcagttcg ttgaacaggt
    11581 gctcgatggc ggtgacggtg atgtgccggg ccggctcctt ggaggggcag gcgtgcgggc
    11641 ccgcgctcca ggcgaggtgc gcgcggttgc tgccggcctg gcgcgaggcc ttgagggccg
    11701 gaccggtgtt ggccgcggcg aagctgacca ggaccaggtc accggagtgc agctgctgcc
    11761 cggcgagttc ggtgtcggcg gccgggtagt gcggcgcgta gttggccatg ggcgggttct
    11821 cccacagcgt atcgtcgagc gcctcgtcga tcaggccgcc ctctcgggcg taccgctcgt
    11881 gggtgaggag ccggtggagg gtgttgccga tgaggttgcg cagcggttcg gcgcccgcgc
    11941 cgagcagcag ggccagctgg tggaccatct cctcgtcgct gaggtccgcc tcgtgccgca
    12001 tcagccagga ggtgacgtcg tcgccgggct tgctccgctt gagtgcgacc agctccccca
    12061 ccgcctggaa cagcacggcg gtggccttgt cggcgttgat cccgtcgaac atgccggaga
    12121 tgccgaacag cacccggtcg ccgatgtcgg cggggcagcc gaagagctcg ttgaacacga
    12181 acagcggcaa ctgccgcgcg tagtcgccca gcaggtcggc cgaaccccgc ccgccgaact
    12241 gcgagatgag gtagccggag atctgctcgg tgctccgggt cagccggcgg gtgtccaccc
    12301 gcgccatgct gtcggtgacc gcctgccgca gcctgaggtg gtcggcgccg tcggcgaaca
    12361 tgcagttggg ccggtaggcc agcagcggcg cgaccggact gtccggtccc accttgccct
    12421 cgttgaaggc ccgccaccga cgcgcgtcct tgcggaacga accggagtcc tggagcagct
    12481 ggagggccgc cgagtagtcc gtcaccagcg tcgcctcgac gcccggtgcc aactcgaccg
    12541 gtgcggcgac cccgtagtgg cgcaggtact cgtagaaggc ctgcggatcg gcggcgaact
    12601 ccggcccgtg caacggcact cgggccccgg agccgtgggc ggggcacccg ggcggaggca
    12661 ccgggaaggt gtcgtgggcg ttcatgtctg ctcccagctc ctagcgggtg cggtccagca
    12721 agtagcggac gagggtggtc agtgcggcgg ccgacgactt ctcgtcgcgg gcgtcgcagg
    12781 tgacgacggg ggtgtcgtcg agcaggtcca gggcctcgcg cagcgcccgc tcgtcccgca
    12841 gcggggcccc gtcgaagtga ttgacggcga tggcgtagtc gaggccgtac tgctcgatga
    12901 ggtcgatgac ggggaaggag tcggccagcc gctcggggtc gaccagcacc agggcgccga
    12961 gcgcgccgcg ggccatgtcc tcccacatct ggacgaagcg ctgctgtccc ggcgttccga
    13021 acaggtagag gacgacgcgg tcgctgatgg tgaggcgccc gaagtccatg gcgaccgtgg
    13081 tggtggtctt gccctggacc cccttgaggt cgtcgaccga ctcggcggcc tgcgtcatcg
    13141 tctcctcggt cgacagcggc tcgatctccg agatggaccc gatgagggtg gtcttgccca
    13201 ccgcgaagtg cccgacgacg aggatcttca ccgcggtctg ggtcgctcca ccgcgtacgt
    13261 agtcctgctc atccaaactt ggcgcggagg ccattgagca cctcctccag gatctccttg
    13321 tccgcgaggc gggcgcgggc caccggcggg cgggtcatga ggtggccgcc ctccatcagg
    13381 gacgccagca ggatccgcac cacgcccagc gggaagtggg tgtgtccggc gatctcggcg
    13441 accgagaggt agccggcgga gcagaggtcc agcaggctct gctcctcggg ggacagccgg
    13501 gtcggccgct gcgtgtgccc ggcggaggcg gtgaccaggg tgatgaggga gaggtgctcc
    13561 tcgtcgggca ggccacggcc cttggtgatg acgtacggcc gtactaactc ggcggcttcc
    13621 ggctcccagc cgtcgtggcc ggtcatgagc gggtgccgag gttctcgcgc ggcggcgtcg
    13681 tcagccgctt gccgagctgg gcgacgagct gctgcatccg gaaggtgatg tccgccatgt
    13741 cgacctccgg ggaggcggag acgccgaggt aggcgccctc tccggcggag atcaggaaga
    13801 cccagccgcc gtcgaactcg accagggtct gccgccacgc ctggtgcggg tcctcacaga
    13861 agaaggcgag ggtgcggctg agcgactgca cgccgctcat ggcggccgcg acccggtccg
    13921 cgtcgtcctt gtcgaagtcc tgcgtccggg ccatcagcag tccgtcggcc gatatcagga
    13981 ccgcgtgcag ggccccggga atctccaggg cgctgtcgag catccatgac agatcgtcgt
    14041 tcacgagtcc tcatgtcctt ctctgcttgc accgggtgtt ctgctcgtcc ggtccgggtc
    14101 ctccggccgg gtgacgcggc cggtctgcgt accccgctgg aaggcggcca tgatctgggc
    14161 ctgctcggag tcggagcggc cggcggagcg cggggtggcg gcactgccgg gcacgatggc
    14221 catcggccgc ttgcggcgcc gccggggcag gccgtcactg gtccgggagg gggcgatcgc
    14281 cgcctccggt ccgccgtccg ggcccgggcg ggcgacggtg tgggctgccg gggagggtgc
    14341 cttcttctcc ggcatggcgg tgagcagctc gtgcggcagc aggaccaccg cgcgcacacc
    14401 tccgtacggg gaggaggagt ccaccgacac ctcgaagccg aagcgctcgc acagcagccc
    14461 gatgaccgcg aagccgaact ggggtggatt gccgaggccc gccacgcccg aggcacgctc
    14521 ggtggcgagc agcttgtcgg cgcgggcgcg ctcctcgtcg ctcatgccga caccggcgtc
    14581 gtcgacgacg acgcagatgc ccttcggcac ggtcctgatg ttgatctcca cgacggtgtc
    14641 cgggctggag tagctggtgg cgttgtcgag gagctcggcg agggccaggg cgacgggttc
    14701 gacggcgcgg ctggtgatgc cgaagtcgac ctgggagagg atctccaccc ggcggaagtg
    14761 ccggatgcgg ccctgggcgc tgcggaccac gtcgtacacc gaggcggtgt cgcgccggcc
    14821 gcccagccag ccgtcgcaca ggaccgcgat cgactgggcg cgacggccga actgcgagtt
    14881 ggtgtggtcg atctccagca ggtcctgcag aagggcggag tcgccgtact tggtctgcag
    14941 ccgggtcagc accagctgct gttcggcggc gaggccctgc agggttcgca tggcggactt
    15001 cagtacggtc ttcgtctcgt cctcggcccg ttcctgagcg gccagcacgg acttcccgta
    15061 atcgttctcc agctccgtgt agtggtccct gagcccctgg atctcctgcc gcagagatcg
    15121 tgccgcccgg cgctggcggc cgatgagcgc ggcggcggcg acgagggcga cgacaaggac
    15181 ccagagcagt gggttcccca agtattccgt cataagactc tcttcaggcg actgacggcc
    15241 ggcttgccgc atgtccgtct acgcgggcgg tccggtggac cgcccgcacc ggggttgctg
    15301 cccgggctgt ccctgaagtc ggggatgccg tctttctccc atccgcccgc tccgcaaacg
    15361 cggtgatcgt atcaccgcat gatcaggtga atttacgtca agaaccgttc atccagggtc
    15421 ggttgagacc ggtctccgcg tgtgccaagg cggtgggtac agtcggcccc gtgaacgatg
    15481 cacaagacac cttcctgccg gtcgcgcggc cggtgcggga cggcgcggcg tgacgcccga
    15541 ggccatggcg gcggtgttca ccgcggggtt cggggccggc gccatcaaca gcgtcgtcgg
    15601 ctccggaacg ctgatcacct tccccgtgct gctggcgacg gggctgtccc ccgtcaccgc
    15661 caccgtctcc aacgccctcg gactcatccc cggctccatc agcggggccg tcggctatcg
    15721 gaaggagctg agcggccagc gccggcgtgt cctcaagctg agtgccggcg cgctgctggg
    15781 cggcctcgcg ggcgccaccc tgctgctgtc cctgccggcc gacgcgttcg agacgatcgt
    15841 gcccgttctg gtgggcctcg ccctgctcct ggtcgccttc cagccccgga tcggcaggct
    15901 ggtgcagcgg cgccgcgaac gcaccggcac ctccccgcgc cgcgacggcg gcccgctgct
    15961 gttcaccggc ctgacgctcg ccagcgtcta cggcggctac ttcgccgccg cgcaggggat
    16021 catctacctg tccctgatgg gcatgcttct cgacgaatcc ctgcaacgtc tcaacgccgt
    16081 caagaacgtc ctctcggccg tcgtcaactc ggtcgccgcg ctcttcttcc tcttcgccgc
    16141 ggacttcgac tggacggccg tcggcctcat cgcggccggt tcggcgctcg gcggctacgc
    16201 gggggccaag gtgggccgtc gtttcagccc ggtggtgctg cgaacgctgg tcgtgaccgt
    16261 ggggacggtc gccctggtgc agctgctgct ccgctgaccc gcggcaccct gccgctacgc
    16321 gcgtcggcgc gcggttcgtg cgtcccggcg ggtgcgcgcc tcgacctcct acccggccgg
    16381 acggtacggc ccgtcgccgc agccaccgtc cgtccccggg ccctgctgat gaccgtgcgc
    16441 gacaggacgg agcccccggt cccgtccgcc gactgaaccc acgggccggg ccggtcggcc
    16501 ggctccacgg ccggcccggt ccgtcgggca taacggcgtg ttatgggaag ccgggattgg
    16561 tggccccgcc tcgccgccgg acatgctgag cgcccccaca cccccacgcg ccgcgacgcg
    16621 cgtcgtcgga atcgaggagc cttgcgcata tccagacccc tccccaccct ggtggccgct
    16681 ctcctggccg ccctgctgtc cgccctcgcg ctcgcgccga gcacctccgc ggcggagccc
    16741 cggcccggtg acggcggccc ccagccgatc atcggcggcg gctacgcgca gaacgccccc
    16801 tgggccgccc ggctgttctc caacggcacc cagacctgca cctcgaccat catctccccc
    16861 acctggatcc tgaccgcgaa gcactgcgtg accggaggag gactctcctt ccgcatcggc
    16921 agcctcgacc agcagtccgg cggcaccgtg gccaacggcg tgcagaccgt cgcccactcc
    16981 tcgtccgacc tcgcgctggt ccggctcgac cgctccgtct ccgcctccta cgctccgctc
    17041 ggacagccgg gcacggtacg ggtcggccag accgtgcagg tctacggctg gggcgccacc
    17101 tcccggtgcg gctcggagat caactgccag tcccgctacc tgaaggtcgc gaacgtcagc
    17161 gtgacccagg ggtgccgcga cgcctacaac ggctcggcga tctgcgcccg tgccgtggac
    17221 ggcatcacgg cgggcggcga ctccggcggc ccgatgacgg ccggcggcat ccaggtgggc
    17281 gtcgcctcca ccagcgaccg gcagtccacc acggcgtaca cgaacgtgac cgcctaccgc
    17341 tcgtggatcc agtcggtagc gggcgtctga tccctctccc ccgccaccgg tcccgcgcgc
    17401 gcccgtcccc gtcccggcgg aggcggacgc acgcgggacc cgacgtgcgc gggcgtcggc
    17461 gggcaggagc ggccaccgtc caccacccgg accgtccggc aagcgcgtgg tgaatgcacc
    17521 tacccttcac cgtgaccgat cggcgtcccg cgcgaaggag gtccggtatg gccgggcaga
    17581 cagccggatc cccggagaac gaacgtgaga cggccgttct ccggctccag gacgtgaccg
    17641 tccgtcgcct gacgacggac cagctgatcc tcgacgggat cgactggacg gtcctgccgg
    17701 gcgaacactg ggccctgctg ggggccaacg gcgcggggaa gaccaccgtc ctgcggctgc
    17761 tcggcgccct catgcacccc acgaccggca cggtggaggt cctcggcagc cggctcggcc
    17821 gggtggacgt ccgcgagctc agggcgcgca tcggccacgt cacctccgcc cagcgggtgc
    17881 cgccggagct cacggcccac acggtcgtgc tcaccggcca cagcggcacc gtgcagcccc
    17941 tgtggcggac gtacgacgac gaggtcaggc tccgtgccca cgacctcctg accgaactcg
    18001 gcgtcaagga gctggccgac cggccgtacg gcgtctgctc gggcgggcag cgggcgcgcg
    18061 tgctgatcgc cagggcgctg atggccgatc cggccctgct gctcctggac gagccgttca
    18121 acgccctgga cctgccgtcc cgcgaggacc tcgtcgaggc catgcaccac ctggcggaca
    18181 gccgaccgcg gttggccacg gtgacggtca cccaccacct ggaggagctg tcccccgccg
    18241 tcagccacgc cctgctgttg cgcgagggcc gggtcctgtc ccgcggagcc gtggacggcg
    18301 tcctcaccga cgccctcctg acggcctgct tcggccggga catcacggtg atgcggcgcg
    18361 acggccgctg gtcggcctac tcgggactcc gcggccacgg gcgctgaaac cgactgcatg
    18421 acgccggcgc ccctcgccgg cgccttcggg gtcgggcgcg gtggaagccg gtgcacccgg
    18481 cgtcggtcag cagaggaggg acacggtccg gcacgcggct tccgcgagcc gacgggcgag
    18541 ctggacgcct gccgctgcca gggcgtcgat gagcgaggcg ggctgtcatc ggcgtgcagc
    18601 tcgacccact cctggttcgt gcggtggacc aacgcctcga tcgtctcgcc ctcggcgaag
    18661 ccgctccgac agccgtgtcc gaggcggacg tggtggtcac cgaggagacg ggcggcgaca
    18721 tcgtgcaccg tccagcgccc ggcggccgac cccgacacgt ccagtggccg gccgggaggc
    18781 gcatgtgctg tccgttgcgg aagcatgacg tgtttccgca acatgacgca ccgacgaagg
    18841 cgtcattgca gcaccggcac agcccaccga cgggccttga ccccccattt ggccccccga
    18901 tagcgtccac ggcatgcgga aatcccggca gttcacaaag aggcgggcca tcgatctgat
    18961 gcgcgtcgcc accgcggtgt gtagctgaac tccaccgccc cactgccctt tcctcccatt
    19021 ccccgtgaag gtcgcaatga cccctcgcac acgcatgccc ggactccggc gcatttccgt
    19081 atcggccgta tgggcccttc ccctccttct caccgcctgc gtggccccgc cgcagtccac
    19141 cgcgagcagc aaggacgtct ccggcgagaa gatcccggcc accgtctccc acgacaccac
    19201 gctcacggtc ggcgcaccgg acctcaaggt cgccctggag ctgtcgggtc agatcgacga
    19261 cctgcccttc aaggtgaagt gggccaacat gagcggcggc ccgcagtgct ccgaggcctt
    19321 ccgggccggc gccctcgacg tctgctcggc cgccgacatc ccgtcgatca acgcgcactg
    19381 gacggggctg gacacgaagc tcgtggcggt gaagttccgc tcggacccga tcaggaaccc
    19441 catctacgag ttgggcacag cccccggctc cggcatccgc aagctgtccg acctacgcgg
    19501 caagaagatc gcctacagcc cgggccaggc ccagggcgcg ctggtcctgc gcatcctgaa
    19561 gaaggcgggc ctcacccagc aggacgtcga actcgtggaa ctcgcgagca ccggagacgt
    19621 ctatcccacg gcgctcggaa atcggcaggt ggacgccgca cccatcgcgg acgtcaacat
    19681 caagcgttat ctcgcgcatt acggaaagga gggcggcgcc accgtcaaac acggcctccg
    19741 ggacgacccc gcgcatctgt gggcgctgac ggagagcgtc gccgacacgg gaaagtcgtc
    19801 cgccgtcagg gaactcgtga agttctgggc acgggcgcag atatggatcg acaagcaccc
    19861 gaaggaatgg gtcgcgggtt actacgtcga ggatcaggga ctcagtcgcg cggacggcga
    19921 atacctcgtc cggcgcgtgg gccatccgga cctgccggcg gactggaccg acgccgtccg
    19981 ccgccagcag cagaccatcg acctgctggc cgaggagcag gaccgggagc cgttcaaggc
    20041 ggatctgctc ttcgaccgcc gctacgagac cgtggccgcc gaggccgtgg ccggcgaagg
    20101 gacgccctca tgagcaccac cctcctcgac gaacaggcgg ccagggcgac gaaggccagg
    20161 accctcgcgg tccgcccgcc ccggccccgc cgcaggcgcc cggggcccgg ccggcccctc
    20221 ccctacggct gggcgatcgg cccggtgctg ctcctcgtgc tctggacggc gggcaccggc
    20281 ctcggcctgg tcgacgtccg cagcctgccc gcgccgtgga ccatcgccga caccgcgggg
    20341 caactgatcg acaacggcaa gctcccgtcc cacctggcca cctccgccca acgcgccctg
    20401 ctcgggctgc tgttcggcgt cgcggccgga ctgctcctcg cgctcgtcgc cggcctcagc
    20461 cgtgtcggcg aggcggtgat cgacggtccg gtgcagatca aacgggccat tccctcgctg
    20521 gcgttgatcc cgctgctcat cctctggttc ggcatcggcg agaccatgaa ggtcatcacg
    20581 atcgcgctcg gcgtcttcgt gccggtctac atccacacgc acaacgggct gcgcgccatc
    20641 gacagccgct acgccgaact cgccgagacc gtgcgcctcg gccggctcgc cttcgtccgg
    20701 cacgtcgtcc ttcccggcgc ccttcccggc ttcctgctcg gcatgcgctt cgcggtcacc
    20761 ggcgcctggc tcgccctggt cgtcgtggaa caggtcaacg ccaccagcgg catcggctac
    20821 atgatggagc tcgcgcggac ctacgggcag accgacgtca tcatcgtcgg cctcgtcgtg
    20881 tacggcctgc tcggcctcgt ctccgacgcc ctggtacgac tcgtggagag gagggccctg
    20941 tcatggcgac gcactctggc gggctgaaca cgaccgagga ccggacggcg gtccgcatcg
    21001 agaacctggt gcgctccttc gacgggcgca cggtgctgga cggactcgac ctgtcgatcg
    21061 cgccgggtga gttcgtggca ctgctggggc gcagtggctc cggcaagagc accctgctgc
    21121 gggcgctg
//
