LOCUS       NZ_CP010449            24230 bp    DNA     circular CON 21-JAN-2024
DEFINITION  Streptococcus pyogenes strain NGAS322 chromosome, complete genome.
ACCESSION   NZ_CP010449
VERSION     NZ_CP010449.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1950469)
  AUTHORS   Fittipaldi,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-2015) Public Health Ontario, 661 University Ave,
            Toronto, Ontario M5G 1M1, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera v. 7.0; Quiver
            Genome Coverage                   :: 114X
            Sequencing Technology             :: SMRT PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/21/2024 01:43:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,960
            CDSs (total)                      :: 1,871
            Genes (coding)                    :: 1,812
            CDSs (with protein)               :: 1,812
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 29 of 59
            Pseudo Genes (incomplete)         :: 33 of 59
            Pseudo Genes (internal stop)      :: 21 of 59
            Pseudo Genes (multiple problems)  :: 20 of 59
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:43:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 817356
            Orig. end                         :: 841586
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP010449.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA available from Nahuel Fittipaldi,
            Nahuel.fittipaldi@oahpp.ca.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24230
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14230](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14230
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(170..1546)
                     /gene="mnmE"
                     /locus_tag="SD89_RS03980"
                     /old_locus_tag="SD89_03980"
     CDS             complement(170..1546)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmE"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888396.1"
                     /locus_tag="SD89_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_03980"
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="WP_053308335.1"
                     /transl_table=11
                     /translation="MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNL
                     EQVASHTINYGHIIDPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEILQL
                     LIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLSQLI
                     NDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRGKILR
                     EGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAG
                     IRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQDSNRIILLNKT
                     DLEQKIELEQLPADLIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISL
                     IEKAVQSLEAVNDGLALSMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
                     "
     misc_feature    1717..1852
                     /db_xref="RFAM:RF00557"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
     gene            1881..2381
                     /gene="rplJ"
                     /locus_tag="SD89_RS03990"
                     /old_locus_tag="SD89_03990"
     CDS             1881..2381
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658294.1"
                     /locus_tag="SD89_RS03990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_03990"
                     /product="50S ribosomal protein L10"
                     /protein_id="WP_002984821.1"
                     /transl_table=11
                     /translation="MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRS
                     LRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTA
                     DALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKE
                     GAA"
     gene            2446..2811
                     /gene="rplL"
                     /locus_tag="SD89_RS03995"
                     /old_locus_tag="SD89_03995"
     CDS             2446..2811
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /locus_tag="SD89_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_03995"
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_002984819.1"
                     /transl_table=11
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAG
                     GAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEA
                     EEIKAKLEEAGATITLK"
     gene            <3070..3654
                     /locus_tag="SD89_RS10250"
                     /old_locus_tag="SD89_04000"
                     /pseudo=""
     CDS             <3070..3654
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /locus_tag="SD89_RS10250"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SD89_04000"
                     /product="replication initiator protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIYLIYSNSK"
     gene            3829..>4154
                     /gene="dcm"
                     /locus_tag="SD89_RS04005"
                     /old_locus_tag="SD89_04005"
                     /pseudo=""
     CDS             3829..>4154
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="dcm"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000670032.1"
                     /locus_tag="SD89_RS04005"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SD89_04005"
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQFLDLFAGIGGFRLGLINQCHECIGFCEIDKFARQSYKAIYETE
                     GEIEFHDIRQVTDQDFRQLRGQVDIICGGFSLVKHFHSQADDWDLRALGELSSLRLLER
                     PNR"
     gene            <4145..5639
                     /locus_tag="SD89_RS10405"
                     /pseudo=""
     CDS             <4145..5639
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294852.1"
                     /locus_tag="SD89_RS10405"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="SAG1250 family conjugative relaxase"
                     /pseudo=""
                     /transl_table=11
                     /translation="TDKNHTHNHIQSTPLTVIQIKN"
     gene            5790..6476
                     /locus_tag="SD89_RS04030"
                     /old_locus_tag="SD89_04030"
     CDS             5790..6476
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /locus_tag="SD89_RS04030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04030"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002984807.1"
                     /transl_table=11
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKG
                     YDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFS
                     LKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYE
                     ILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGI
                     GYKWDV"
     gene            6469..7815
                     /locus_tag="SD89_RS04035"
                     /old_locus_tag="SD89_04035"
     CDS             6469..7815
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984805.1"
                     /locus_tag="SD89_RS04035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04035"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_053308337.1"
                     /transl_table=11
                     /translation="MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSH
                     NVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKN
                     NLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVAL
                     TRFVKEISLNFKEIKKLANKMGIEVLSEKENYSKIIEFDDILRTLHIKGDNLKSLIERE
                     ILEKQDLSFQIAALSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYF
                     NSLISYTRMLSEDRPVKLILVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEE
                     NLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFY
                     TEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI"
     misc_feature    complement(7844..7859)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            7972..8112
                     /locus_tag="SD89_RS04040"
                     /old_locus_tag="SD89_04040"
     CDS             7972..8112
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528609.1"
                     /locus_tag="SD89_RS04040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04040"
                     /product="lantibiotic streptin"
                     /protein_id="WP_002984803.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.8e-09, bitscore:
                     32.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTIKDFDLDLKTNKKDTATPYVGSRYLCTPGSCWKLVCFTTTV
                     K"
     gene            8227..10017
                     /locus_tag="SD89_RS04045"
                     /old_locus_tag="SD89_04045"
     CDS             8227..10017
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /locus_tag="SD89_RS04045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04045"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_038434071.1"
                     /transl_table=11
                     /translation="MIKAQLKNLIKTIHLVKEAGFSLLVFSIAISLFQGILPIFSMLLV
                     QKMLNIITTDIKNFHTLMIAFISYIALTLLTIIIGEVDSYIDTKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVSLISSFVILLNWKI
                     SIFPLLLILPIVSIYIYLKISKNEFEILYKRSSDERANWYISHLLTHDFAVKELRLGTL
                     ESYFLKKYDKNNQLFINQENSINRSKMKYGIVLGVLEIAIQSIIMFLAVREAFLGILLV
                     GNVTTFIRSLSTMQTSTQNIVNNIYSFYNGSLYMELLYDFTHDELVHNPIIESTVDTIQ
                     SVEFERVSFSYNGKDNVINDISFSIKAGERLAIVGENGSGKSTIFKLACGLYDNYEGNI
                     YINGINLRSIQKKSYYKRISALFQDFLKYELTLRENVGLGELSKLYSDEDLISALKYTG
                     VDSIFYFNQEKLNQIDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYLLDEPSS
                     ALDPESETKIFKTFFELSQNKIGIFITHKPSITQSVNKILYLDNGCIAETGSFADLNIK
                     GMKFKNLLDKEIGATYDTSN"
     gene            10001..11245
                     /locus_tag="SD89_RS04050"
                     /old_locus_tag="SD89_04050"
     CDS             10001..11245
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989896.1"
                     /locus_tag="SD89_RS04050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04050"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_002989896.1"
                     /sec_met_domain="LANC_like (E-value: 7.7e-78, bitscore:
                     258.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQIKQIVDYIADSFINYEQIVAESENKVLINIESKYRNTFFDK
                     SLSHGVPSLILMYSSLYKVTKDERYLTFSNIYVEKLVDIISRDGIESPSLYAGTAGIAL
                     AIKEASISGKYYPKLLSSLNCLLKEQIKDKLVVSFSNIEKGIIEPYDYDMVNGFSGITN
                     YLLLEQEFFSVELNQIGNYLLKYIETILNKVTNCSEDREAEFDLGIAHGITGPMLILAK
                     LKSEKILSVEVGDILNKAINLMFLFRRDDKLWPGKIYTSNILDLDLNYLPTRMAWCYGT
                     PGTAVALFKMCQLIDLNFIDDINESLIAQMRSSDKNVYSLTMCHGLAGVTFIYDLIGKN
                     YSSERLTRFAEELRQQIITSFSTTKVFGYTDREKFGEIEVELESIGILQGVSGIVLFLL
                     NPYSDEELLWQRIFI"
     gene            11264..14230
                     /locus_tag="SD89_RS04055"
                     /old_locus_tag="SD89_04055"
     CDS             11264..14230
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528611.1"
                     /locus_tag="SD89_RS04055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04055"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_053308338.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.5e-90, bitscore:
                     299.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-11,
                     bitscore: 41.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.9e-13, bitscore:
                     47.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKVFPTGMIRIPLQKQEFYNKDYEDLINDKVFMEQLLVASPSLY
                     DSVIDFDKCNEKKKQNVKVSLNSYSKRAAFRTTPFGIFTAINTVDLTKGTTSNVQKVSF
                     IKKAVPDYSWIYSLVKSYEISNLEKLSLKINTAAFTQGDRYVLPFTVNESEEDRNISFS
                     KPIKLLVEKCKTRYIKYEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPPICN
                     INSLDYLLSKLEEGTLCTDLTTLKKMIEDYNDLNIGEGRDLLLQIFDKMESIYKYDNGG
                     NYLKVDSLAEYEGGFNILSETARESIERLAEMFVKLNTNVKRRGGRKNSLEEYQLKFIG
                     KYGENCSIPFVEVINKDAGIGFPEYYKGGEGEAIELSDPIMQMFEKKYEEALLNGGHIE
                     FYSKDLDDFQTDQSNSLDSFELNFNIKIINNDVKLYLGANIGSGQAGRSFGRFYGLSET
                     VRETIKNLNHQNNTNVELSFVPKQIRLANVIQNYSDESYNTSFFTTSWDSENELRLEDI
                     YIRYSDGKFHFTTIDGKNELNFTMNNMLNSDSQSRVLRLLVDLSEFEYGLSHWSLFPWD
                     ILAQERVYIPEILFEDITITTAQWNLSAIREEIIHQKIFTGKKDIFNKFRKTYKIPKDI
                     ILKYADNELRLDLSIDSDLEILFKNINKYRFVSLRGIEQGESIFKDNLGNYNTEIVVPI
                     LKESNGINNTNDNVQFKNEVKKIYLPFCDWLFFKFYGPKERQEELLNNWKKFWLNLPSE
                     LFSQSNMFYMRYNDTNDHIRIRINCDSIENNFSLYLSVVQDLLPQLIESCIISDIEVSS
                     YKPEVNRYGGPHLISYAEEIFCKESILFLNNTIEFSDDERLVCATYLVLYYLNHFFKDK
                     ETRRSFLFENYTGKYKKDFKNLPIDLPIEYMKILNGVTSALDRYDFFQEIDRYLMSYMK
                     EYNRFGGTNDIYNTKFNLVGSFLHLSMNRLNGIDREFEEKVYCFAYYTLNAQQYIEWE"
     aSDomain        11666..11920
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SD89_RS04055_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="2.60E-13"
                     /identifier="RREFam001.1"
                     /label="SD89_RS04055"
                     /locus_tag="SD89_RS04055"
                     /protein_end="219"
                     /protein_start="134"
                     /score="41.5"
                     /tool="antismash"
                     /translation="NTAAFTQGDRYVLPFTVNESEEDRNISFSKPIKLLVEKCKTRYIK
                     YEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPP"
     gene            14236..14925
                     /locus_tag="SD89_RS04060"
                     /old_locus_tag="SD89_04060"
     CDS             14236..14925
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922274.1"
                     /locus_tag="SD89_RS04060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04060"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_019418719.1"
                     /transl_table=11
                     /translation="MLKIQNLKKSYGKRTILNNVNMNIPKGKVYALIGPNGAGKSTIMK
                     ILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVSES
                     AILPLLNKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIGIQE
                     LREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIVLEKEYDGSENLEELFNNQ
                     ILFEKRR"
     gene            14931..15680
                     /locus_tag="SD89_RS04065"
                     /old_locus_tag="SD89_04065"
     CDS             14931..15680
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984791.1"
                     /locus_tag="SD89_RS04065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04065"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_002989889.1"
                     /transl_table=11
                     /translation="MVQIFLSNLFKIKNTSISKLILIFPIICVMLSLLFSALGGESILR
                     LAAETTVNQWGVIWINVIIAVNSGLLNKLELDSNKYSVFLSRDVDLKKVEYARVLLIAL
                     INLIISMILSLMLIVISFVLPTPSLISIGRILLTILLIWLTTLWQIPFILWLSRKINVY
                     FAMIINIISPLIIGTSFSLLNKWYLFPYDWSLKLLEPMTRMRINSIPFGAEFVPDYSQI
                     FISLFLGIAFFILLTNLFAISFKKQVK"
     gene            15683..16405
                     /locus_tag="SD89_RS04070"
                     /old_locus_tag="SD89_04070"
     CDS             15683..16405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922276.1"
                     /locus_tag="SD89_RS04070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04070"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_053308339.1"
                     /transl_table=11
                     /translation="MKSYLCSNFLKIKNTSYLLIHILAALLFPLLLFFYWSQRGGLQSR
                     TVLFSYFQIVGVLLPFVASIVCIQLKNLEESSGKYKYLLGYSQSNYKPFIVELVFLWLC
                     YCIVLIISITIFILLLKTIGINVSLRLLILNSLIYIIFAYVTYLINHIISYIFSTGVAL
                     GISMVGVIVAAFCETSLGDKVWFLIPWAWLLRISDTLYNQQKMAIVPLVVIFFVSCTVA
                     LLHIRIFKSWNQDCLTSS"
     gene            16596..16826
                     /locus_tag="SD89_RS04075"
                     /old_locus_tag="SD89_04075"
     CDS             16596..16826
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775551.1"
                     /locus_tag="SD89_RS04075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04075"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_053308340.1"
                     /transl_table=11
                     /translation="MYPRIRNLREDNDFTQKFVANLLSFSHANYAKIERGEVALMADVL
                     VQFSKLYNVSIDYLLGQTDYPYRFHNKKVSP"
     misc_feature    complement(16626..16637)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     misc_feature    complement(17084..17099)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            17113..17334
                     /locus_tag="SD89_RS04080"
                     /old_locus_tag="SD89_04080"
     CDS             17113..17334
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106749.1"
                     /locus_tag="SD89_RS04080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04080"
                     /product="DUF3173 family protein"
                     /protein_id="WP_053308698.1"
                     /transl_table=11
                     /translation="MNIGFLEHTARNIIREAKRIAIKKFEEARELEQNAVQLSKSPFDN
                     RRLGIAPKDIVEELVGILLSEESLESEN"
     gene            17337..18524
                     /locus_tag="SD89_RS10595"
                     /pseudo=""
     CDS             17337..18524
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106750.1"
                     /locus_tag="SD89_RS10595"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIKNQKKYKGVYCDKNGKILYQADLGVDPVTSKRVQKKARKN"
     gene            18682..19917
                     /gene="pbp3"
                     /locus_tag="SD89_RS04105"
                     /old_locus_tag="SD89_04105"
     CDS             18682..19917
                     /EC_number="3.4.16.4"
                     /codon_start=1
                     /gene="pbp3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922278.1"
                     /locus_tag="SD89_RS04105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04105"
                     /product="D-alanyl-D-alanine carboxypeptidase PBP3"
                     /protein_id="WP_080370135.1"
                     /transl_table=11
                     /translation="MIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEADSGRVL
                     YEKDAKMPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFD
                     KKTYSVQDLLTATLVASSNSAAIALAEKVADSELHFVNQMREQLSHWGITSGKILNASG
                     LPNEVLKDHRYPGSALEEENTLSAQDVAVVTMHLLEDFPEILEITKQTEVNFAGNSIKS
                     FNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTRF
                     EQANRLLDYVARTYCRRKILKKGSLVLERSLPIQDGQVKELPVSVAEDVTIILQQGEQV
                     PKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLKEPKRIPLKASQSRKKASDL
                     QLWWRDFLEKRR"
     gene            complement(20034..20996)
                     /locus_tag="SD89_RS04110"
                     /old_locus_tag="SD89_04110"
     CDS             complement(20034..20996)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407556.1"
                     /locus_tag="SD89_RS04110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04110"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_011017736.1"
                     /transl_table=11
                     /translation="MNNRHKRRQKRKAFTLINLILLFACILGLTLIFYLYQGSNKFGLS
                     DVSQFVPKISLFHHKKTAKKETTKLKKTHFDSSKSQKKAHSKLTWTKQETPVKIPILMY
                     HAIHVMSPEETANANLIVNPDLFDQQLQKMKDEGYYFLSPEEVYRALSNNELPAKKVVW
                     LTFDDSMIDFYNVAYPILKKYDAKATNNVITGLTEMGSAANLTLKQMKEMKQFGMSFQD
                     HTVNHPDLEQASPDVQTTEMKDSKDYLDKQLNQNTIAIAYPSGRYNDTTLQIAARLNYK
                     LGVTTNEGIASAANGLLSLNRIRILPNMSPENLLQTMEP"
     gene            21328..22605
                     /locus_tag="SD89_RS04115"
                     /old_locus_tag="SD89_04115"
     CDS             21328..22605
                     /EC_number="6.3.2.-"
                     /GO_function="GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995327.1"
                     /locus_tag="SD89_RS04115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04115"
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="WP_053308344.1"
                     /transl_table=11
                     /translation="MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIV
                     GTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRP
                     LTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVV
                     CPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWE
                     WQEQFQMAENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTPD
                     HIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTK
                     PIVDMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVI
                     TGSLYFISEIRKYWEKHIEKSVLLTH"
     gene            22659..23225
                     /gene="folE"
                     /locus_tag="SD89_RS04120"
                     /old_locus_tag="SD89_04120"
     CDS             22659..23225
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989871.1"
                     /locus_tag="SD89_RS04120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04120"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_053308699.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 8.2e-77,
                     bitscore: 253.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLG
                     LGKDPKEEFTAVFKEQHEDVVIVKDISFYSICEHHLVPFYGKAHIAYLPSDGRVTGLSK
                     LARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRGIKKPGSKTI
                     TTTARGLYKESRAERQEVISLMIKD"
     gene            23234..24025
                     /gene="folP"
                     /locus_tag="SD89_RS04125"
                     /old_locus_tag="SD89_04125"
     CDS             23234..24025
                     /EC_number="2.5.1.15"
                     /GO_function="GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="folP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528620.1"
                     /locus_tag="SD89_RS04125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_04125"
                     /product="dihydropteroate synthase"
                     /protein_id="WP_053308345.1"
                     /transl_table=11
                     /translation="MKIGRFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMI
                     ADGAKIIDVGGESTRPGCLFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAAL
                     EAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAA
                     LDAGVPKNNIWIDPGFGFAKSVQQNMELLKGLDRVCQLGYPVLFGISRKRVVDALLGGN
                     TKAKERDGATAALSAYALGKGCQIVRVHDVKANQDIVAVLS"
ORIGIN
        1 gatgaaaaca ctatgcacca agctaatgaa tatatgcctt tagaaaatat ttatcgctca
       61 gcagctattt atgctgaagc aatctacgaa ttaattaaat aagatgctta tgatagcaaa
      121 aagagctgga acactgttcc agctcttttg tgatgattag agactgttgt tatttaccaa
      181 gacagaattg actaaagagt tgggtaatga gttcatcagg agcagcatcc cctgtgattt
      241 ctccgagaat ttcccaagtt ctggttaaat caacctgtag taaatcaact ggcatgctaa
      301 gcgccaagcc gtcattgaca gcttctaaac tctggactgc cttttcaatc aaagaaatgt
      361 ggcgggcatt tgacaggtaa gtggcatctt gctctaccaa accagcatta tcaaagaaga
      421 gctggttgat acgatcttcg atcagattaa tgttctggtt ggttaacacc gaaataggaa
      481 taaggtccgc tggcaactgt tccaattcaa tcttttgttc caaatccgtt ttattcaaca
      541 atataatacg gttactgtcc tgactgagat ttaacaaagc ccggtcttgg tcggtcagtt
      601 tttcagaagc attcagcaca agaagaacaa ggtcagcttc ttgaagagct tttttagacc
      661 gttcaactcc gatttgttcg accagatcat ctgtctcacg aataccggcc gtatcgacaa
      721 gttttagagg aactcccttg atattaacgt attcttcaat gacatctcgg gtggttcctg
      781 caatatcagt cacaatagcc ttgtcttctc gcaacaaatt attaagtaag cttgacttac
      841 cgacgtttgg acgaccaata atagctgttg ataagccctc acgcagaatt ttaccgcgtt
      901 tagctgttcg aaggagattt tccaaaaggc tttggaattc ttgtgttttc tcacgtagca
      961 gagcagtggt catttcttcc acatcgtcgt attcagggta gtcaatattg acttcgactt
     1021 gagctaaggt gttgagaatt tcctgacggg tgtcattgat aagctgggaa agggagccat
     1081 ccagttgctt gactgcaatc gtcatagcct tgtctgtttt ggcacgaata atgtccatga
     1141 cagcctcagc ttgagtcaaa tcaactcgcc catttaagaa ggcacgtttg gtgaattcgc
     1201 caggctctgc cattctagcg ccttggcgaa tcaatagttg caagatttca tttgtcacag
     1261 caataccacc gtgcgtattg atttcaacca cattttcacg ggtaaaggtt ttgggggcta
     1321 gcatgactga caccataact tcatcgataa tagttcctgt cttaggatca atgatatggc
     1381 catagttaat ggtgtgtgag gcgacttgct ctaagttctt tcccttaaaa acagattgtg
     1441 caatggcaag cgcatctgtc ccggatagac gaacaatgcc aatagctcct tcaccaagag
     1501 gggttgaaat ggcggtaatt gtatcaaatt ctttagttat actcatgccc tctattttaa
     1561 atcaagtcct agtagaaagc aaggtattat tttgtataga aaataggact agcaccattt
     1621 tgagtttagc taatactaaa aaaaataaat gtaaaaaaat cattttttta ataattttta
     1681 ttgacaatag tattataaaa gaatataata atataggttt tgataaaaaa ctgacctaag
     1741 acagcagggg agcatgctca taatattcct gccgaggcac aaaacgtgat taaagaaaat
     1801 aacgtatttg tactttcgtg tctaggttta ggtgcgattt ttttgtacct agcccaaaaa
     1861 taaaaacgga ggtaaaacta atgagtgaag caattattgc taaaaaagct gaacaagtcg
     1921 aacttattgc tgagaaaatg aaagcagcag caagtatcgt tgttgttgat tcacgtggtc
     1981 ttacagttga tcaagatact gttcttcgtc gttcacttcg tgaaagtggc gttgagttca
     2041 aagttatcaa aaactcaatt ttgactcgtg cagctgaaaa agcaggtctt gatgagttga
     2101 aagatgtatt cgtaggacca tctgcagtag cattttctaa cgaagatgtt atcgcaccag
     2161 ctaaagttat caacgacttt actaaaactg ctgacgcact tgaaatcaaa ggtggtgcaa
     2221 tcgaaggcgc tgtttcttca aaagaagaaa tccaagcact tgcaacattg ccaaaccgcg
     2281 aaggaatgct ttctatgctt ctttctgtac ttcaagctcc agtccgcaac gttgcatacg
     2341 ctgtcaaagc tgttgcagaa aacaaagaag gcgctgctta agacgtctca gagtagctta
     2401 aggctacgct taacatttta aattaattat ttggaggaaa tcacaatggc attgaacatt
     2461 gaaaacatta ttgctgaaat taaagaagct tcaatccttg agcttaacga tcttgtaaaa
     2521 gctatcgaag aagaatttgg tgtaactgca gctgctcctg tagctgctgc agctgctggt
     2581 ggtgctgaag aagctgctaa agattcattc gacgttgaat tgacatctgc tggcgacaaa
     2641 aaagttggcg ttatcaaagc tgttcgtgaa atcacaggtc ttggtcttaa agaagctaaa
     2701 ggtcttgttg atggagcacc tgctaacgtt aaagaaggcg ttgctgctgc agaagctgaa
     2761 gaaatcaaag ctaaacttga agaagctgga gcaacaatca ctcttaaata agaagcagat
     2821 agcaatttga gagcgaaatc ccgatttatc agtcttttag agcttatagc gatttgaaga
     2881 aattgataaa atgatttggt tttttgccaa aaatcctgcc aaaaaaatct ttggcaggat
     2941 ttttattttc tataaaaatt aagctgagta gagtggttat tctatctata tgtgtctagt
     3001 aataattttt ttattttcag gaggaaaatc atgcaaatga atgaacagtc atcacgacaa
     3061 atggtgattg ccatttatct catttattcc aactcaaaat gatagtactc cttggctgtt
     3121 ccaagtcgaa attgttagtg attaagaaaa cctacgagac tatggtttga tcgatgaagg
     3181 ccagcagtct cccagtgaaa aagggcgttt ggctaataag atttatttag gaaagttgga
     3241 acatgatttc accccagtct taagttcaga cggggccagt ctcaaaaaca gaccagcccc
     3301 gtgttaaatt cagcccctag tgagactgaa aagagtgaaa ctgaagagag taatttagtc
     3361 attgaggacg aggaggaaag aaaggagtgc actagtgtga aaaagactga gggtcacttt
     3421 actcgtcaag ttgatcatgt caccaaatat gacaaagatt atatttggag tttggttcat
     3481 tcccaattac gtgaaggtgg tttatcacaa gctgctagtg acttagtcat gagctatttt
     3541 gaagaacgct atgcttatgc gctggaacac atacggttcg caagaacagc tgaagctatt
     3601 gcggaatatg tctttaatgg tgtcttatcc gaatggacca agcaactaag gtgacaagaa
     3661 gcgaagtgag taagatgttt tggtggctat tattaggtgt ttggggacta aggacaattt
     3721 ggttgattat tgaagttatc actgcaccag aaatggaaga ttatagttga gtaaggacgt
     3781 tacataagca gtaaggtcct tttattttgt cagaaaggaa tgagagatat gcagttttta
     3841 gatttgtttg caggaattgg aggctttcga ttgggtttaa ttaatcagtg ccatgagtgt
     3901 attggctttt gtgagattga taagtttgcg aggcaatctt acaaagccat ctatgagacc
     3961 gaaggagaaa tagaatttca tgacattaga caagtcacag accaagactt tagacaactt
     4021 agagggcaag tggatatcat ctgcggtggt ttttcccttg tcaagcattt tcactcgcag
     4081 gcagacgact gggatttgag ggcactagga gaactctctt ctttgagatt actcgagcga
     4141 ccaaacagat aaaaatcata cccataatca catccaatca acgccattga ccgtaattca
     4201 gataaaaaat tgatatggaa ttatgccttg gaacgaaacc tccgtatgat ttcagaccgt
     4261 atttcaaaaa tgactggagc aaaaattatc gagaagcgtt attcctaccg tgactatcaa
     4321 aaatataggc agtctagtca taaatttgaa ttgaaacaac gtctttattt tttgatgcag
     4381 cagtcaaagt tctttgatga ttttttagaa aaagcagagt aattacatgt tcatattgat
     4441 tttagtcaga agcatagcag attcatgatg acggatcgag taatgaaaaa accaattcga
     4501 ggccgtcaac tcagtaagcg agatttatat gatgaagaat tttttcgtac acattttgcc
     4561 aagatagaaa ttgaaagtcg attagaattt ttgttgaacc gtgccaattc attagaggag
     4621 ctactattaa aagcaaaaga agtgaatcta accattgact taaaacaaaa aatgtaactt
     4681 ttatcctaga agaagatact caaaagataa gtttaagtca taaaaaaata agcgataaga
     4741 aattatatga tgtcaatttt ttcaagatta ctttaaaaat aaggaagtcg gtgtttcaga
     4801 tcgattagaa agtctacaga aacagtacat gcttttcaag aagaacgaga taaagaggag
     4861 gtatccactg aagagagtaa ggaagtcttc aagaaataca aggggcaacg agatgccatc
     4921 catgagtttg aagttgaact tgtggaacat caaattgaga ggttaattgc tgaggacatt
     4981 tatatcaagg tgtcttttgg tgtaaagcag agtggtctta ttttcattcc taactatcaa
     5041 ttggatatta ggaaagaaga aaatcataaa aaatataaag tctatattcg tgagaccgca
     5101 caattcttca tttacaacaa ggaggcgtct aaacttaatc gctatatgcg agggcgtgag
     5161 ctcatttacc agttaaccaa tgatagcaag agtattccaa aaagaagacg accaaaacca
     5221 ttgatacact taagaaaaag attgaagaaa taagtctcct cattgagtta gatacggaga
     5281 ataagcctta tcaagatatt aaagatgaca ttgttaaaga tatggctcaa ttagatttga
     5341 ccattacaga gttgcaggac catattgctc atctcaataa ggttgcggag gtcttgctta
     5401 atctgaacaa caacgatata gagaaccgcc gtttggccag atatgactat gccaagatga
     5461 acttgactgc agctataaaa atagaagaag ttgagaaaga gattgaaact tctcaaaatg
     5521 aacttaatat atccatagat gagtatgaat atctagtaag aaggttggaa aagtttggag
     5581 agatcttgag ttatagcaaa attatcgata cttctcgaaa tgaaatacaa tgggagtaat
     5641 tatgatataa tttgggtggt agcaattttt atatcagata ttaaaatcta gttgatgttt
     5701 cgtaaataac tatattaaag aaatgattcc tgccgcttac attgagaata gtttatttgt
     5761 aagtatttca ttatttaaaa ggggtaataa tgtataagat tttagccata gatgatgata
     5821 aagaaattct gaagcttatg aagactgctt tggagattga aaattaccat gttataacct
     5881 gtcaagagat agaattacca atagtttttg atgattttaa aggatatgat ttgatcttat
     5941 tggatatcat gatgcctaat ataagtggaa ctgagttttg ttataaaatt cgggaagaag
     6001 ttcattctcc aattattttt gttagcgctt tagatggcga taatgaaatt gtccaagctt
     6061 taaatatagg gggagacgat tttattgtga aaccatttag cttaaaacaa ttcgtagcta
     6121 aagttaactc tcatttgaag agagaagaga gagcaaagat aaagaatgag gctgaggaga
     6181 gagtgaagcg cagttttcca cctatagaaa tctatctaga ggaacgtatg ttatatattg
     6241 ataaacagcc gttattcctg acttatagag agtacgaaat tttagaatta ctgtcacgtc
     6301 atccgtataa agttttcaca aaagaagaga tatatgaaca agtatatagc gatgaagctt
     6361 cagcattgtt tcattctatt tcagaatata tctatcagat tagaatgaaa ttttcaagtt
     6421 ttggaattaa tccaataaaa actattcgcg ggattggtta taaatgggat gtttaaaaaa
     6481 tattcaataa aaaatcgtgt ttggcgcgcc gtcgttgaaa ttgtctttgg agtttgtatc
     6541 actgttttaa tgattgcgat aatatcgctt tctttttcaa agttaaatat agtgacatct
     6601 cataatgtgg gagaagaatt ttatattaaa gataaacagt caatcaaaca gttgaacaat
     6661 tatatgaaga cattgggatt agattatgtt gtttttgata gaaaaacaga taaagctatg
     6721 gaaggaaaat atttatctaa agaattttct ttatttaacg aagttgcaga agaaaaaaat
     6781 aatctgactt ttaattctgt gcattatgat ttatatacta atatcaatta taatattgtt
     6841 ataagatata atgagatacc ggagttctct aaccattacc ttagaaatgt ttcatataac
     6901 atgttgacat tttatattct gggaatagga acgagtatca gcattgtagt tgctttaaca
     6961 cggtttgtaa aagaaatttc tttgaatttc aaggaaatca agaagttagc aaataaaatg
     7021 gggatagaag tcctttctga aaaggaaaat tattctaaaa taatcgagtt tgatgatata
     7081 cttagaactt tacatattaa aggtgataat ttgaaaagtt tgattgagcg agaaatattg
     7141 gaaaagcaag atctatcctt tcaaattgca gcactttcgc atgatataaa aacaccttta
     7201 acggttttga aaggaaatct tgagttatta gaattgacta ctttaaataa aaatcaggaa
     7261 ggttatattg tatctatgaa caatagtatt tctgtttttg aaggctattt caattcttta
     7321 atatcttata cacgcatgct ttcagaggat agaccagtga aactaatttt agttgaggag
     7381 ctattaagtg agttacattt tgaagtcgat gacttattga atatcaataa tattgaattt
     7441 tctatttgta atagacttat tatcacttct ttttatggag atgaggaaaa tctgataaga
     7501 gctctttcta accttttagt taatgcaata agatttatgc ccgtattaga taaaaaaatc
     7561 gaagttatac tgtctgagtc aggagagcaa attcattttg aaatatggaa taatggtgag
     7621 cgtttcagtg atagtacact gaaaaaggga gataaattat tttacacgga agattatagc
     7681 agaggtaaca aacattatgg aatcggtttg gcatttgtta aaggcgttgc tatcaaacac
     7741 ggtgggaatc ttcaattgaa taatccagct agaggaggtg ctagcgccat aatctcgata
     7801 aaaaagaaaa tttaatagat ttgattgaaa ctggagtatt tcaggcaaaa aatcgtaaat
     7861 ttttgtgatt tttggctaaa atactttttt tctgaacaaa ttctgaactt ggggtgtcat
     7921 aataatcatg taaatatatc ggatgcaaaa acgtaagaga ggaactagaa aatgaataac
     7981 acaattaaag actttgatct cgatttgaaa acaaataaaa aagacactgc tacaccttat
     8041 gttggtagcc gttacctatg tacccctggt tcttgttgga aattagtttg ctttacaaca
     8101 actgttaaat aataaagtta tcattatcat caacattata atttcaaata atttgatata
     8161 tttataaatt taggggagta gactgatttt agtttgctcc tttattagta gataaggaag
     8221 ttatacatga ttaaagctca gctaaagaat ctaataaaaa caattcatct cgtaaaagag
     8281 gctggtttct ccctactggt gttctcaatt gctattagct tatttcaagg gattttaccc
     8341 atttttagta tgctactagt tcaaaaaatg ttaaacatta taacgactga tataaaaaat
     8401 tttcacacat tgatgattgc ttttatctca tatattgctt taacattatt gacaattata
     8461 ataggagaag ttgatagtta tattgatacc aaattacaga tacttcttca ctataagatg
     8521 aaccatttag ttatgcagaa aactgtaaag ttaacattgg ctgaatttga gacaccagaa
     8581 atctatgatg atatcactcg catacaaaat caaatatctt ataaaccttt tcaaatatat
     8641 aagtcaatta tttctgtatt atcttcgtta gtatcattaa tttcctcatt tgttatttta
     8701 ttaaattgga agatatcaat ttttccactt ttacttatcc ttcctatcgt ttctatatat
     8761 atctacttga aaattagtaa aaatgaattt gagatactat ataaaaggag tagcgatgag
     8821 agagcaaatt ggtatattag tcatctttta acacatgatt ttgctgtcaa ggagttgagg
     8881 ttaggtacgt tagaaagtta ttttctaaaa aaatatgata aaaataatca attatttatt
     8941 aatcaggaaa atagtataaa tagatctaaa atgaaatacg gcatagtatt aggtgtattg
     9001 gagattgcta tacaatctat tattatgttc cttgcagtta gagaagcatt tctaggaata
     9061 ttattagttg gaaatgtaac tacttttata aggtctttat ctacaatgca aacaagtaca
     9121 caaaatatag taaataatat ctattctttc tataatggtt cattgtacat ggagttattg
     9181 tatgatttta cgcatgatga gttagtacat aaccctataa tcgaaagtac ggttgataca
     9241 attcagtcag ttgaatttga aagggtttct ttttcatata atggtaagga taatgtcata
     9301 aacgatataa gtttttcaat taaagcagga gagaggttag caattgttgg tgaaaatggt
     9361 tctggaaaaa gtacgatttt caaattagcc tgcggtcttt acgataatta tgaaggcaat
     9421 atatatataa atggtattaa tcttcgttca atacagaaaa agtcatacta caagagaata
     9481 tccgcattgt tccaagattt tttaaagtat gaattgacac tgcgtgaaaa tgttggattg
     9541 ggtgaattat caaagttata tagtgatgag gatttaataa gtgcactgaa gtatacagga
     9601 gttgattcga tattttactt taatcaggaa aaattaaatc agatagatct ggaacagcaa
     9661 ttagggaatt ggtttgagga tgggagacag ttatctggtg gacagtggca aaaaattgca
     9721 ttatcaagag tatatctcaa agaagcggat tgctatttgc tagatgagcc tagttctgcg
     9781 ttagatcctg agtctgaaac aaaaattttt aaaacatttt ttgaattatc gcaaaataaa
     9841 attggtattt ttattacgca taagccaagc attactcaat ctgtgaataa aattttgtat
     9901 ctagataatg gatgtatagc tgaaacagga agtttcgctg atttaaatat taaaggaatg
     9961 aagtttaaaa acttattaga taaagaaatt ggagccacat atgacacctc aaattaaaca
    10021 gatagtagat tacattgcag atagttttat aaattatgaa cagatagtag ctgaaagtga
    10081 gaataaagta ctaattaata ttgaatctaa atatagaaat accttttttg ataaatctct
    10141 gagtcatggt gtgccatcat taatcttaat gtatagttca ctatataaag tgacaaaaga
    10201 tgagagatat ctaacattct ccaacatata cgttgagaaa ttagtagaca taatctctag
    10261 agatggtata gaatctccgt ctctctatgc tggcactgca ggtattgcat tagctattaa
    10321 agaagcgagt atatctggaa agtattatcc gaaattatta tcatccttaa attgtcttct
    10381 aaaagaacaa attaaagaca aattggtagt aagtttttct aatattgaga aaggaattat
    10441 tgagccatat gattatgata tggttaacgg atttagtgga ataactaatt acttactcct
    10501 tgaacaagaa tttttttctg tagagttaaa tcaaattgga aattatcttt tgaaatatat
    10561 tgagacaatt ttaaataagg taactaattg ttctgaagat agagaagctg aatttgatct
    10621 aggaattgca catggaatta ctggtcctat gctaatccta gcaaaattaa aatcagaaaa
    10681 aattttgagt gtagaagtag gagatatact gaataaagct ataaatttaa tgtttttatt
    10741 tagaagggat gacaaactat ggcctggaaa aatttatact agtaatattt tggatcttga
    10801 tttaaattat cttcctacta gaatggcatg gtgttacggt acgcctggaa ctgcagttgc
    10861 cctttttaaa atgtgtcaat tgatagattt aaattttatt gacgatatta atgaaagttt
    10921 aattgctcag atgagaagtt cagacaaaaa tgtctattct cttacaatgt gccatggttt
    10981 ggcaggagta acttttatat atgacttgat tggtaaaaat tattcaagtg agaggctaac
    11041 tcgctttgca gaagagcttc gccaacaaat aattacatcg ttttcaacta caaaagtatt
    11101 tgggtatact gacagagaaa aatttggaga aatagaagtt gaactggagt caatagggat
    11161 attgcaaggg gtatcaggga tagtgttatt cttattaaat ccttacagtg acgaggagct
    11221 attgtggcaa agaatattta tttaatttga aaaggagaac aaaatgtata aggtatttcc
    11281 aactggtatg attcgtattc cattgcaaaa acaagaattt tataataaag actatgaaga
    11341 tttaataaat gataaagttt ttatggaaca acttttagtt gctagtccca gtctttatga
    11401 tagtgtaata gattttgata aatgtaatga aaagaaaaag caaaatgtaa aagtctcatt
    11461 aaatagttat tctaaaagag cagcgtttag aactactcca tttggtatct ttactgctat
    11521 taatacagtt gatttgacaa agggaaccac ttctaatgta caaaaggtta gttttattaa
    11581 aaaagcagtc ccagattatt catggatata ttctctagta aaatcgtatg aaataagtaa
    11641 ccttgaaaaa ctttcattaa aaataaatac agcggcgttt actcaaggtg acagatatgt
    11701 actaccattt acagtgaatg aatcagagga agatagaaac ataagttttt caaaaccaat
    11761 taagttactt gtagaaaaat gtaaaactcg atatataaaa tatgaagagt taatagatgt
    11821 atttaaaaat aattatccag atatagtgtc agacatgcta gagtcatata tacacgactt
    11881 agttacaaat gattttttaa tttcagattt aagaccacca atttgtaata tcaattcctt
    11941 agattatcta ctatctaaat tagaagaagg aacactatgt actgacttaa ctactttaaa
    12001 gaagatgatt gaagattaca acgatttaaa tattggggaa ggtagagact tacttttgca
    12061 gatttttgat aaaatggaaa gtatttataa atatgataac ggtggaaatt acttaaaagt
    12121 tgattcatta gcagagtatg aaggcggttt taatattcta tctgaaacgg ctcgggaaag
    12181 tatagaacga ctcgcagaga tgtttgtaaa attaaataca aatgtaaaga gaagaggggg
    12241 gaggaaaaat tcacttgaag agtatcagtt gaaatttatt ggcaaatatg gagaaaactg
    12301 ctcaattcct tttgttgaag taataaataa agatgcaggc ataggttttc ctgaatatta
    12361 caaaggagga gaaggtgaag caatagagtt aagcgatcca ataatgcaaa tgtttgaaaa
    12421 gaaatatgag gaagctctat taaatggagg gcatatcgaa ttttattcaa aagatttaga
    12481 tgattttcaa acagatcaaa gcaatagttt agattcgttt gaattaaatt ttaatataaa
    12541 aataataaat aatgatgtga agttatattt aggagctaat atcggttctg gacaagcagg
    12601 tagaagcttt ggaagattct atggattaag cgaaacagta agagaaacaa ttaagaattt
    12661 aaaccatcaa aataatacga atgtagagtt gtcatttgtt cctaaacaga taagacttgc
    12721 gaatgtaatt caaaattata gtgatgagtc ttataatact tcatttttta ccacatcatg
    12781 ggattcagag aacgaactgc gattggagga tatttatata agatatagtg atggtaagtt
    12841 tcattttaca actatcgatg ggaaaaatga gttgaatttt accatgaata atatgctaaa
    12901 ttccgatagc caaagcaggg ttttgagatt gttggttgat ttatctgagt ttgagtacgg
    12961 tttatcgcat tggtcattat ttccttggga tattttggct caggaaagag tatatattcc
    13021 tgaaatttta tttgaagaca ttacgattac cactgctcag tggaatttat cagcaattag
    13081 agaagagatt atacatcaaa aaatatttac tggtaaaaaa gatatattca ataagtttag
    13141 aaagacttat aagataccta aagatattat tttgaaatat gcagataatg aattgaggtt
    13201 agatttatct atagatagtg atttagagat tttatttaaa aacattaata aatataggtt
    13261 tgtttctttg agaggaattg agcagggaga gtctattttt aaggataatt tagggaacta
    13321 caatacagag atagtagttc caattcttaa ggaatctaat ggaataaaca atacaaacga
    13381 taatgttcaa tttaaaaatg aagttaagaa aatatattta ccattttgtg actggctatt
    13441 tttcaaattt tatggtccaa aagagcgaca agaagaatta ctaaataact ggaaaaaatt
    13501 ttggctaaac ctgccatcag aactgtttag ccaaagtaac atgttttata tgagatataa
    13561 tgataccaat gatcatataa gaattcggat aaattgtgat tcgattgaaa ataacttttc
    13621 tttgtatttg tcagtagttc aagatctatt acctcaactg attgagagtt gtattatctc
    13681 tgacatagaa gtgagtagct ataaaccaga agtaaataga tatggaggac ctcatttaat
    13741 aagttatgca gaggaaattt tttgtaaaga atctatctta tttcttaata atacaataga
    13801 attttcagat gatgaaagat tagtttgtgc tacttacttg gttctatatt atctaaatca
    13861 ctttttcaaa gataaagaaa caaggcgctc tttcttattt gagaattata ccggaaagta
    13921 taagaaagat ttcaaaaatt tgccaattga tttacctatt gagtatatga agattttgaa
    13981 tggagtcacc tcagctcttg atagatatga ttttttccaa gaaatagata gatatctcat
    14041 gtcttatatg aaagagtata atcgatttgg tggtacaaat gatatctata atactaaatt
    14101 caatttagta ggaagttttt tacatctatc aatgaatcga ttaaacggga ttgatagaga
    14161 gtttgaagag aaagtgtatt gttttgctta ctatacacta aacgctcagc aatatataga
    14221 atgggagtaa ctaatatgtt gaaaatacaa aatctaaaaa aatcttatgg taagagaacc
    14281 atattgaata atgtcaatat gaatattcct aagggaaaag tgtatgcttt aatcggtcca
    14341 aatggtgctg gaaaatcaac tattatgaaa attttgacag gcttagttag taagacaagt
    14401 ggttctatta tttttgaagg tagagaatgg tcacgtcggg atctgcgaaa aatcgggagt
    14461 attattgaag aaccaccact ttataaaaat ttgagtgctt acgataatat gaaggtagtt
    14521 acaacaatgc ttggtgtttc agaaagcgct atacttccat tattaaataa agttggtcta
    14581 ggaaatattg acaagagacc agtaaaacaa ttttctcttg gaatgaagca acggttaggt
    14641 atagctatct ctttaataaa ttcacctaaa ttacttatat tagacgaacc tactaatggc
    14701 ttggacccaa ttggaattca agaattaagg gaaattatag agtcatttaa atcagaagga
    14761 atgacaatta tgatttcaag ccatatactg tcagaagttg aacatctagc tgattttatt
    14821 ggatttatct atgaaggaaa gattgttctg gaaaaagaat atgacggctc tgagaatctt
    14881 gaagagttat tcaataatca aattttattt gaaaagagga ggtaggggct atggtacaaa
    14941 tttttttatc aaatttattt aaaataaaaa atacgagtat tagcaagttg attcttattt
    15001 ttcctattat ttgtgtgatg ttatctttat tgttttcagc attaggtggt gaaagtatcc
    15061 tacgtttagc tgcggaaaca acagtaaatc agtggggagt tatttggatt aatgttatta
    15121 ttgctgtaaa ttctggtttg ttaaataaat tagaattaga ttctaataag tattctgttt
    15181 ttttatcaag ggatgttgat ttaaaaaagg tagaatatgc cagagttcta ttgatagctc
    15241 ttataaatct aataattagt atgattttaa gcttaatgct tattgtgatt agttttgtcc
    15301 tacctactcc aagtcttatt agtataggta ggatactatt aactatcttg ttaatttggt
    15361 tgactacact atggcaaatc ccgtttattt tatggctatc aagaaaaatt aatgtgtatt
    15421 ttgctatgat tattaatatt atatctccac taattattgg tacaagtttt tctctcttaa
    15481 ataaatggta tttgttccct tatgattggt cgttgaagtt gcttgagcca atgacaagaa
    15541 tgagaataaa tagtatacct tttggagcgg agtttgttcc agactactca cagattttta
    15601 tatcattgtt cctaggaatt gcttttttca tcttactgac caatctattt gctatctctt
    15661 tcaaaaaaca ggtgaaatag tcatgaaatc atatttatgt tctaattttt taaaaatcaa
    15721 aaatacttca tatttactaa tacatatttt agctgcacta ttatttccct tacttctatt
    15781 tttctattgg agtcaacgtg gaggtttaca aagcaggact gtattatttt cctactttca
    15841 aatagtaggt gtacttcttc cttttgttgc aagtattgtg tgcattcaac taaaaaattt
    15901 ggaagaatca tctggaaaat ataaatattt attgggttac tcacagtcga attataagcc
    15961 atttattgta gaattagtat ttctatggtt atgctattgt atagtattaa ttatttcaat
    16021 tactatattt attcttttat tgaaaactat tggtataaat gtatctctca gactacttat
    16081 tttgaatagt ttaatttata tcatttttgc ctatgtaacc tatctgatca atcatattat
    16141 tagctatata tttagtacag gtgtggcatt aggtatttca atggtaggtg ttattgttgc
    16201 agctttttgt gaaacgagcc ttggtgataa ggtatggttt cttattccat gggcatggct
    16261 tttaagaata tcagatactc tatataacca acagaaaatg gcaattgttc cacttgttgt
    16321 tatatttttt gtttcatgca cagtagcttt acttcatata cgaatattta aaagttggaa
    16381 tcaagactgt ttgacaagta gttaaataca tctattttgt ttacctaaca ataaatatga
    16441 tttttaagtt ataaatacta tctaacttgt ttaactaaaa aatgactata aaatttcaat
    16501 ggtttactag cttatattta atagacttgt ccaaatagga caattaaaca ttttttaatc
    16561 aaatctcctt tatactgata ttaggagaat gttagatgta cccgcgtatt aggaatttga
    16621 gagaagataa cgatttcact caaaagtttg ttgcaaattt actttccttc tctcatgcaa
    16681 attatgcaaa aattgagaga ggagaggttg ccttaatggc agatgttctt gtgcagtttt
    16741 ctaaactcta taacgtcagt attgattatt tattagggca aacagattat ccgtatcgtt
    16801 ttcataataa aaaagtctcg ccttgattta ttcattgaca actgaataaa ccgaggtggg
    16861 actttcttgt ttgtcgagca atttagtgag atgcgccgtg ataggagcga taattattag
    16921 ctataaaata gagtggttct ctatctgcca tgaccacaaa tagggacaat gatacttctg
    16981 aacattcagg ctgccagcgt aaaaggccag tgggtgagat tcccatgagt gatttaacca
    17041 gtcataccca cggaggttgt aatttttttg aaaggagtgg aggtgtgaaa atagtaacat
    17101 ataaaaagct tgatgaatat tggttttctc gaacatactg caagaaatat tattagagaa
    17161 gcaaaaagaa tagctataaa aaagtttgaa gaagctcgcg aacttgaaca aaatgcggta
    17221 caattaagta aatcgccctt tgacaataga agacttggta ttgctcctaa agatattgta
    17281 gaagagttag taggtattct actctctgaa gaaagtttag aaagtgagaa ttaaagatga
    17341 ctataaaaaa tcaaaaaaag tacaaaggtg tttattgtga taagaatggg aagatacttt
    17401 atcaagctga tcttggtgta gatccagtaa caagtaaacg agttcaaaag aaagccagaa
    17461 agaattagta tggaaagcca tttggtacaa tgaaagaagc gtatgatgaa ctggttcgga
    17521 ttaggtatga gtttagtaat aatcttagta ttgaaaatga caatatatcg tttgaaaact
    17581 atatgaatac tatttaccta agagcatata agcaaaaggt tcaggctgta acttatgaaa
    17641 tagccttacc acatcataag ttatttattc agtattttgg ttctaaactt ttaaagggaa
    17701 taacagcttg agattgtgaa tcttttagtt tacatattat tgaaaattat gcaaagaatt
    17761 tatggtcgcg attcaaagct tgcatggggt atgctgaaag gttagactat atttcaaaag
    17821 tgccgtgtaa ggctttggat aatcctaaag ggaaacatcc cgacactcca ttttggactt
    17881 atattgagtt tcagaatttt ataaaatcgt ttgatttgca agattatgaa gagctacaaa
    17941 gatttacaac tatttggcta tattatatga caggtgttcg tgtaagtgaa ggtttatcat
    18001 tatgatggga agatatcgat ttcgaacaaa aattcttgaa agttcataca accttggaaa
    18061 atgatgaaaa tggaaattgg tatcgtaaag accaaacaaa aacgccagca ggagaacgtc
    18121 ttattgagtt agatgatgtg ataatagtag tattggaaaa ttggagaaga aatcaagtag
    18181 tcaatactga cacagatttc attatttcac agtttggtga accgttttat aaatcgacaa
    18241 tctatcgact tattaagcac aaagctcaag aagtaggagt accagtgata acgggaaaag
    18301 gcttgcgaca tagtcatgct tcctatctta ttaatgtttt gaaaaaagac attctgtacg
    18361 ttgcaaagtg tatgggacat gctgataagt ctacaacttt gaatacatat agtcactggt
    18421 ttaatgcatt agataaagca gtatctgaag aaataaccca aaatgtgata agttcaggat
    18481 tagattccat tttataccaa aattcctgcc aaacaactaa ttgatataac gaagcttatt
    18541 atatcgtcca tataacagga tgtgttattg ttacagggta cttgctttat gagcttgttt
    18601 aagctactaa aggtgtgtgc cactatactt ccttccaaat ttctgagaat ttttgctata
    18661 atagtaacta tgaaagatat aatgataaaa aggtgggtta tccttttttt tatggtatta
    18721 acttgttcag ggtttggtaa aacagttctc gcagctgatt ttcaagtggg agcagaacat
    18781 gcgattgtcg tagaggcaga ctctgggaga gttctgtatg agaaagacgc taagatgcca
    18841 gatgctattg cctctttgac caaattggtg acggcttatc tggttttaga taaggttaaa
    18901 tcaggccagc tgcaattatc agatcaagtt aatctctcag attatgcctt cgagttaaca
    18961 aaagataggt ctttaagtaa tgtacctttt gacaaaaaaa cttattcagt tcaagacctg
    19021 ttgacagcta ctttggtagc aagctcaaat agcgctgcta ttgcgttggc cgaaaaagtg
    19081 gcggattcag agcttcattt tgtaaatcaa atgagagaac agctatctca ttgggggatt
    19141 acttctggta aaatcctcaa cgcctcaggt ctgccaaatg aggtgttaaa ggaccatcgt
    19201 tatcctggtt ctgcgttgga agaagaaaat accttgagtg ctcaagatgt tgcagttgtg
    19261 acgatgcatt tgttagaaga ttttcctgag attttagaga tcaccaaaca aacagaagtt
    19321 aattttgctg gcaattctat taaaagtttt aatcaactct taccaggtat ggctaagggt
    19381 agagcaggag tggatggttt aaagactggg acaacagact tggcaggtca ttgtcttgtg
    19441 gtaacttcta ttgaaaatgg tatgcgagtg attaccgtta ttctaaatgc cgatggatct
    19501 gataaaaacc aaaacacgcg gtttgagcaa gcaaatcgtt tgttggacta tgtggctaga
    19561 acttattgtc gtcgtaagat tcttaaaaaa ggaagtcttg tcttggagcg gtcgctccct
    19621 attcaagatg gccaagtaaa agaactaccg gtatccgttg ccgaagatgt aaccatcatt
    19681 ttgcaacagg gtgaacaagt tcccaaacct aaacaattta tgatatcaga gacttcttta
    19741 ctagcaccga ttactaaagg tgaagtggtt gcttatttga cgtctccaag aataacagat
    19801 cagtcagtga ggtatttaaa ggaacctaag cgtattcctc ttaaagctag ccaatctcga
    19861 aaaaaagcct ctgacttaca gctgtggtgg cgagattttc ttgaaaaaag acgttaaaga
    19921 taagaataaa ataattttaa aacaatcaaa aaaagacagt tatgaaagaa ttttttcata
    19981 actgtctttt tagtttacag tgagtatgat ttggaatgat aaaaaaattg atgttatggt
    20041 tccattgttt gtaaaagatt ttccggactc atgtttggga ggatacgaat ccggttaaga
    20101 gaaagaagtc cattagccgc gctagctatt ccttcgttag tggtaacacc taatttatag
    20161 ttaagtctag ctgcaatttg taaggtagtg tcattatatc taccagatgg ataagcaatg
    20221 gcaatagtgt tttggtttaa ttgcttatca agatagtcct ttgaatcttt catttcagtt
    20281 gtttgaacat caggactagc ctgctctaga tcaggatgat tcactgtatg atcttggaaa
    20341 gacataccga attgtttcat ttctttcatc tgcttaagag tcagattggc agcgcttccc
    20401 atttcggtta gtcctgtaat aacattattg gtggctttag catcatattt ttttaagatt
    20461 gggtaagcaa cgttgtagaa atcaatcata ctgtcatcaa atgttagcca tacaactttt
    20521 ttagcaggca attcattatt tgaaagagcg cggtagacct cttcaggact caaaaaatag
    20581 tagccctcgt ctttcatttt ttgaagttgt tgatcaaaga gatctgggtt gacaatcaaa
    20641 ttagcattag ccgtctcttc aggggacatt acatgaatag catgatacat taaaattggg
    20701 atcttgacag gtgtttcttg cttggtccaa gttaatttag aatgggcctt tttttgagat
    20761 tttgaggaat cgaaatgagt cttcttaagt tttgtcgttt ctttttttgc cgtctttttg
    20821 tgatgaaaaa gacttatttt aggtacaaat tgagagacat ctgacaagcc gaatttgtta
    20881 gacccttgat ataaatagaa aatgagggtc aaaccaagaa tgcaggcaaa taatagtata
    20941 aggttaatga gagtgaaggc ttttcttttt tggcgccgtt tatgtctatt gttcattact
    21001 tgctcctttt tttgatataa gtacctctat tgtaacattt tttagagaaa agaaggcttg
    21061 aagtcagcct tttttcttgt tttttggaag aacgtgtatt aaggagtaaa aaaatattgt
    21121 cacagataac actttaggag gtagcaaaga ctatgtgggg ctggtattct tatcacgtaa
    21181 aaaaagcaat gaaaataaaa gtgtagtgta ctttagaact tatttgagtg tttggtgagg
    21241 ataataaaaa aaaagggtac tactctaggt tatctgctgt cacttttttt tatatatggt
    21301 atactaaaga tagatgtgag gtatgaaatg acttatgaag agactctaga atggattcat
    21361 gatcacttag ttttcggcat caagccaggc ttaaaacgta tgctttgggt tcttggacag
    21421 ttaggaaatc cccagaaaaa tgtcaaggga gtgcatatcg ttggaactaa cggaaaaggt
    21481 tccacggtca atcatttaca acacatcttt acgacagctg gttatgaagt ggggaccttt
    21541 acctctcctt atattatgga tttcaaagaa cgtattagca taaatggtcg aatgatttca
    21601 gaaaaagatt tggttattgc tgctaatcgt attcgtcctt tgacagagcg tctagttcaa
    21661 gagactgatt ttggagaggt aactgaattt gaagtgatta ctttgatcat gttcctctat
    21721 tttggtgata tgcatcctgt agatattgct attattgaag caggccttgg cggtctttat
    21781 gattcgacca atgtttttca agcaatggtt gtggtctgtc cctcaattgg tttagatcac
    21841 caagctattt tgggagagac ttacgctgat attgccgccc aaaaagctgg tgttttagaa
    21901 gggggcgaga cccttgtttt tgccgttgaa aacccgtcag ctcgagaggt ttttttaaca
    21961 aaagctgagc aggttggtgc ttcaatctgg gaatggcaag agcagtttca aatggctgag
    22021 aacgcatctg gctatcgttt tactagtcct ttaggagtta tttcagatat tcacatcgct
    22081 atgccaggac accaccaagt gtctaatgca gctttagcta ttatgacttg cttaaccttg
    22141 aaagaccgct atcctaggct aactccagat catataaggg aaggtctggc aaatagtttg
    22201 tggctaggcc gtaccgaatt attagcacca aatctaatga ttgatggagc tcataacaat
    22261 gaaagcgttg ctgctttggt agccgtctta aaaaataact acaatgataa aaagcttcat
    22321 attttgtttg gtgcgatcga caccaagcct attgtagata tgttggttgc tcttgagcaa
    22381 ataggtgact tgcaggttac tagctttcat taccctaacg cctatccatt ggaaaaatac
    22441 ccagaacgtt ttggtagggt tgctgatttc aaagatttct tggccttgcg taagcatgct
    22501 aaagcagatg actttttcgt gattacaggg tcactatatt ttatttcaga aattagaaag
    22561 tattgggaaa aacatattga aaaaagcgtt cttttaaccc attaaaaaaa gagaaaatga
    22621 aaaggaaaag gaaaaaacta atgaaaaggg aaagactaat gtctattaat aaggaaaaag
    22681 cagaagcagc catttatcag tttttagagg ctattggtga aaatccaaat cgagaaggtc
    22741 ttcttgacac gcctaaacgg gttgctaaaa tgtatgcgga gatgtttttg ggactgggaa
    22801 aggatcctaa agaggagttt acggctgtct ttaaagaaca acatgaggat gtggtgattg
    22861 tcaaagacat tagtttttat tctatatgtg aacaccactt agttcctttt tatggcaagg
    22921 ctcatatcgc ttacttgcca agtgatggtc gagtaacagg tttgagtaaa ttagcgcgag
    22981 cagttgaagt agctagtaaa cgacctcaac tccaagagcg tttgacctct caaatagcgg
    23041 atgctttagt tgaagccctc aatcctaaag ggactttagt tatggtagaa gcagagcaca
    23101 tgtgcatgac catgcgaggc atcaaaaagc caggtagtaa aaccattacc accactgcca
    23161 gaggcttata caaggaaagt cgtgctgaga ggcaagaagt tatttctcta atgataaaag
    23221 attaggagga cttatgaaaa ttggaaggtt tgtgattgag ggcaatgcgg ctatcatggg
    23281 gattttaaat gtgactccag attctttttc agatgggggg tcttacacta ctgtgcaaaa
    23341 agcattagat cacgttgagc aaatgattgc tgatggtgct aaaatcatcg acgttggtgg
    23401 agaatcaaca cgtccaggtt gcctatttgt aagcgctacc gatgaaattg accgggtggt
    23461 tcctgtgatc aaggccatca aagaaaacta tgatattcta atcagcattg atacctataa
    23521 aaccgaaaca gctagagcag ctttagaggc gggtgccgat attctcaatg atgtttgggc
    23581 aggtttgtac gacggtcaaa tgtttgcctt agcagccgag tacgatgcgc ctatcatctt
    23641 gatgcataac caagacgaag aagtttatca agaggtaaca caagacgttt gtgattttct
    23701 aggcaataga gcacaagcag ctcttgatgc tggcgtgcca aaaaacaata tttggattga
    23761 tccaggattt ggatttgcca aatctgttca acagaatatg gagttattaa aaggattgga
    23821 ccgcgtctgt cagttgggtt atcctgtctt gtttggtatt tcgagaaagc gtgtcgtaga
    23881 tgccttgtta ggcggcaaca ccaaagctaa agagcgagac ggagcgacag cagccttgtc
    23941 tgcttatgcc cttggaaaag gctgtcagat tgtacgggtg catgatgtca aggctaatca
    24001 agacattgtg gctgttttga gctagttgat gtgaggactt atggataaaa tcgtattaga
    24061 aggttgccgt ttttatggct accatggagc ctttaaagaa gaacagaccc ttgggcaaat
    24121 ttttctggtt gatttagaat tgtcagtcga tttgcaagca gcttctttgt cagaccaatt
    24181 aacagatacg gtccattacg ggatggtgtt tgacagtgtc cgtcagttag
//
