LOCUS       NZ_CP010449            23767 bp    DNA     circular CON 21-JAN-2024
DEFINITION  Streptococcus pyogenes strain NGAS322 chromosome, complete genome.
ACCESSION   NZ_CP010449
VERSION     NZ_CP010449.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1950469)
  AUTHORS   Fittipaldi,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-2015) Public Health Ontario, 661 University Ave,
            Toronto, Ontario M5G 1M1, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera v. 7.0; Quiver
            Genome Coverage                   :: 114X
            Sequencing Technology             :: SMRT PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/21/2024 01:43:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,960
            CDSs (total)                      :: 1,871
            Genes (coding)                    :: 1,812
            CDSs (with protein)               :: 1,812
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 29 of 59
            Pseudo Genes (incomplete)         :: 33 of 59
            Pseudo Genes (internal stop)      :: 21 of 59
            Pseudo Genes (multiple problems)  :: 20 of 59
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:43:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 568134
            Orig. end                         :: 591901
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP010449.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA available from Nahuel Fittipaldi,
            Nahuel.fittipaldi@oahpp.ca.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23767
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23767
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23767
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13767](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13767
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(529..540)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(618..2159)
                     /locus_tag="SD89_RS02870"
                     /old_locus_tag="SD89_02865"
     CDS             complement(618..2159)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /locus_tag="SD89_RS02870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02865"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_053308274.1"
                     /transl_table=11
                     /translation="MLHLHLETKLQDKLSLLNILLDVSEVSIDQLCQETELKKQRVYNL
                     LIEMIKDLEDTLTLTICDDTVSIPYKTYQLKMPYFKKLYQTSIFLKMLCFLIEPGELSL
                     HDFIKREYISQATAYRIRTNCRKYLKKVGLNVRQNHVVGPEYRIRFLIALLHYQFGMTI
                     YDFDKTSMNKVVSLIINSNQAITLNDASKAPYEFSYFAILISLIWKRRHDNLGIPQTDA
                     FKHLKKLSIYHDIKMTSQEIIGKWYHPDLTDEDLDYIFLCFCTTNNPFHKDKWTPKKVK
                     ELFELVMTKTNGKTLKASLRPLLSDNILNSLPFKRILVSFSRLFISNLQVLLPDIHLFH
                     YLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYHLLLFTIQLEELLKTYLSPIPVY
                     LLTNNTAALDLMTNALSIYFLPAIATVMPVNVEIIPFKDIVKEKQSVIIADRQYLNLIQ
                     HLYQNQGHLFLYFLFSFRDVSEAYIHKAFLDFRQKRYDEFIVTLLDTYHKNLSSP"
     gene            2631..9137
                     /locus_tag="SD89_RS02875"
                     /old_locus_tag="SD89_02870"
     CDS             2631..9137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285469.1"
                     /locus_tag="SD89_RS02875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02870"
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_053308275.1"
                     /transl_table=11
                     /translation="MFLKHHDVKQKNWRMRKVKKVFVSSCMLLTVGLGVAVPTGFSQSN
                     GVMVVKAAEAEENLFAFSDDKSGISLLSSKKHIGRYFATTTDEYTNFSKFYVQESHTSY
                     QNKWVNHYVTANNPGKKDDSQIWAGSDGTAKIKFLNVFKDSKRANSLALRINTKEVQNG
                     HKYLMEVTETNTGQVKTDYRISAAFDGSPSSIGINLKDTEKKKASNITFSDGNGASLNQ
                     GYENRKSGKRVLTFRSNVDEAISLTVIASVPDIPNREGEVSLSKMKVTDITPAPIVNLK
                     ADVDTQSKKVSVKLEDENRKNFVGDEIQVYRLTPEGTQELVGKVTVSHKNSNLVDIPLD
                     SEKLIDNPLKVNERLVFKTVQKHSKKTNDKAGEAVVKLSESIVQEQEKAQIQLKKVYEQ
                     TKESIKTDKWLPATKTEDVNLQNTNKETQLALLEERYEEAQKAIKDAITTEKITEQLKK
                     YASVGDKETYPNSLPNQHVKGNKAQEQQKAKEDLTKLHKEIEKKITDDPWLTEEARKQQ
                     LAAEKKAFAKGNQAIEGAQNLTSLREVVQQFSVDEKGAEEKKHPDSLPNQYIPADEQAI
                     KMVKKTSLKELRDITVSAIQKDLWLTPEEKIKQIKQADEALKKGEVFVENSQNLKELED
                     GLKNYIIKDNRDESIPNKYQAGKKDELTNKAEVKLKEAHEATKQAIEKDPWLSPEQKKA
                     QKENAKARLDAGLKAVETTESLDKLKEVESDFLDKEKAESIPSQHQAGTPEVARKTFLD
                     NFEKEAQKELESIKNDVTLTDAEKATAKAKVEAQLQEAKDKAKESKSFDDLKNIQDKFN
                     SELPHTPGKPLKDQQSDAIAELEKKQQEIEKAIEGDKTLPRDEKEKQIADSKERLKSDT
                     QKVKDAKNADAIKKAFEEGKVNIPQAHIPGDLNKDKEKLLAELKQKADDTEKAIDSDKT
                     LTAKEKEEQKAKTKEELQKATEAVGAIDNREELDKKVPELKKAIEDTHVKGNLEGIKNK
                     AIEDLKKVHDETVAKINGDDTLDKATKEAQVKEADKALAAGKDAITKADDADKVSTAVT
                     EHTPKIKAAHKTGDLKKAQEEANTALDKAAEKEREEINNDITLTAKDKEQQLKEVETAL
                     TKAKDNVKAAKTADAINDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAKATKDKI
                     SADPTLTSKEKEEQSKAVDAELKKAIEAVNAADTADKVDDALGKGVTDIKNQHKTGDPV
                     EARRGLHNKSIDEVAQATKDAITADTTLTEAEKEIQRGNVDKEAAKAKEELAKAKDADA
                     LDKAYGDGVTDIKNQHKSGDPIEARRGLHNKSIDEVAQATKDAITADTTLTEAEKETQR
                     GNVDKEATKAKEELAKAKDADALDKAYGDGVTSIKNQHKSGKGLDVRKDEHKKALEAVA
                     KRVTAEIEADPTLTPEVREQQKAEVQKELELATDKIAEAKDADEADKAYGDGVTAIENA
                     HVIGKGIEARKDLAKKDLAEAVAKTKALIIEDKTLTDDQRKEQLSGVDTEYAKGIENID
                     AAKDAAGVDKAYSDGVRDILAQYKEGQNLDDRRNAAKEFLLKEADKVTKLINDDPTLTH
                     DQKVDQINKVEQAKLDAIKSVDDAQTADAINDALGKGIENINNQYQHGDGVDVRKATAK
                     GDLEKEAAKVKALIAKDPTLTQADKDKQTAAVDAAKNTAIAAVDKATTADGVNQELGKG
                     ITAINKAYRPGEAVKARKEAAKADLEKEAAKVKALIAKDPTLTQADKAKQTAAVDAAKN
                     TAIAAVDKATTAEGINQELGKGITAINKAYRPGEGVKARKEAAKADLEKEAAKVKALIA
                     KDPTLTQADKGKQTAAVDAAKNTAIAAVDKATTAEGINQELGKGITAINKAYRPGEGVK
                     ARKEAAKADLEKEAAKVKALITNDPTLTKADKAKQTEAVAKALKAAIAAVDKATTAEGI
                     NQELGKGITAINKAYRPGEAVKARKEAAKANLEKVAKETKALISGDRYLSETEKAVQKQ
                     AVEQALAKALGQVEAAKTVEAVKLAENLGTVAIRSAYVAGLAKDTDQATAALNEAKQAA
                     IEALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALKTAIATVRSAQSIASVKEAKDK
                     GITAIRAAYVPNKAVAKSSSANHLPKSGDANSIVLVGLGVMSLLLGMVLYSKKKESKD"
     gene            complement(9323..>9439)
                     /locus_tag="SD89_RS10110"
                     /pseudo=""
     CDS             complement(9323..>9439)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611995.1"
                     /locus_tag="SD89_RS10110"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLTLKTKEEVHWWNYHHLHSNLNYQTPITK"
     gene            10001..10162
                     /gene="sagA"
                     /locus_tag="SD89_RS02880"
                     /old_locus_tag="SD89_02875"
     CDS             10001..10162
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="SD89_RS02880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02875"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 1.9e-29, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    complement(10169..10186)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            10384..11334
                     /gene="sagB"
                     /locus_tag="SD89_RS02885"
                     /old_locus_tag="SD89_02880"
     CDS             10384..11334
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="SD89_RS02885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02880"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_010922108.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-32, bitscore:
                     110.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     aSDomain        11331..11600
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SD89_RS02890_Cytolysin_C_RRE.1"
                     /evalue="1.90E-42"
                     /identifier="RREFam014.1"
                     /label="SD89_RS02890"
                     /locus_tag="SD89_RS02890"
                     /protein_end="90"
                     /protein_start="0"
                     /score="134.5"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIISQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLML"
     gene            11331..12389
                     /locus_tag="SD89_RS02890"
                     /old_locus_tag="SD89_02885"
     CDS             11331..12389
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="SD89_RS02890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02885"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_053308276.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 1.3e-40,
                     bitscore: 134.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 9.5e-140, bitscore:
                     462.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIISQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQVLPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     gene            12409..13767
                     /locus_tag="SD89_RS02895"
                     /old_locus_tag="SD89_02890"
     CDS             12409..13767
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="SD89_RS02895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02890"
                     /product="YcaO-like family protein"
                     /protein_id="WP_032464274.1"
                     /sec_met_domain="YcaO (E-value: 4.1e-63, bitscore: 210.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 4e-111, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEMILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            13742..14413
                     /locus_tag="SD89_RS02900"
                     /old_locus_tag="SD89_02895"
     CDS             13742..14413
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="SD89_RS02900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02895"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_002994083.1"
                     /sec_met_domain="Abi (E-value: 1.3e-08, bitscore: 32.0,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVFIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            14410..15093
                     /locus_tag="SD89_RS02905"
                     /old_locus_tag="SD89_02900"
     CDS             14410..15093
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="SD89_RS02905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02900"
                     /product="SagF family protein"
                     /protein_id="WP_002985270.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLMALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            15116..16039
                     /locus_tag="SD89_RS02910"
                     /old_locus_tag="SD89_02905"
     CDS             15116..16039
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="SD89_RS02910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02905"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            16048..17175
                     /locus_tag="SD89_RS02915"
                     /old_locus_tag="SD89_02910"
     CDS             16048..17175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="SD89_RS02915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02910"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_023613056.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIHLTGVSPS
                     LLVLGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILSLIGMRKQVTT"
     gene            17172..18290
                     /locus_tag="SD89_RS02920"
                     /old_locus_tag="SD89_02915"
     CDS             17172..18290
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985264.1"
                     /locus_tag="SD89_RS02920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02915"
                     /product="ABC transporter permease"
                     /protein_id="WP_053308277.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLVGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALIIFSSLLLKPTRL"
     misc_feature    complement(18297..18310)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     misc_feature    complement(18527..18538)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    complement(18644..18659)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     gene            18861..21593
                     /locus_tag="SD89_RS02925"
                     /old_locus_tag="SD89_02920"
     CDS             18861..21593
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="SD89_RS02925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02920"
                     /product="SpnA family nuclease"
                     /protein_id="WP_053308278.1"
                     /transl_table=11
                     /translation="MINKKCIIPVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGTDVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVRVGDVLTISGEVEEFFGHGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     regulatory      21758..21873
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            21871..22371
                     /locus_tag="SD89_RS02930"
                     /old_locus_tag="SD89_02925"
     CDS             21871..22371
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="SD89_RS02930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SD89_02925"
                     /product="QueT transporter family protein"
                     /protein_id="WP_023613067.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTIALGELVSLLIGSLIIDKLSQR
                     ISF"
     misc_feature    complement(23598..23612)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     misc_feature    23624..23635
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
ORIGIN
        1 gccgttacca cattccagta ttactcacca gttggtgcaa ataagatgtg ttccagttca
       61 ggaaaagtga cttgtaagat cttgtgaagg cgattcttaa ctctcgaaca atattatcct
      121 cagtcaagtt ttgatagaag cgactcaagt cacgtagcag ctgataaact tcttcctgaa
      181 cgtaagttgg ttttctaact aaaataaatt gagactgagc caatttttca gtgtctaact
      241 tatccgcttt acgcacccgt agactatcta gttttctaaa ggattgagtt gtgtataagc
      301 gtagccattt ttctcaagga aggactgaag ccgacgagaa tagactcctg ttgtgatggt
      361 ctcccttttg ccttttaaac aatagtatag ccgtttttca aaatgttatt aatgattttt
      421 tcctttattc tagaagaata agtctgatac tgtttcttct taataatctc aatgccctaa
      481 caatccatca gtcgaacggt atttctcaaa ttactgcagt tgactcttgc gttcagttcc
      541 ctcaccttgt ggatgccgtt tagaacaata ttagcttgct gagccttttg gtaatgtgaa
      601 caaagcatct ttatcactca aggagaagac aggttcttgt ggtaagtgtc caacaaggtc
      661 acgataaact catcgtaccg tttttggcgg aagtctagaa atgccttatg aatgtaagcc
      721 tcagaaacgt ctctaaaact aaacaagaaa tacaagaaca aatgcccttg attctggtac
      781 aaatgctgta tcaggttcag gtattgccta tctgcgataa tgacactctg cttttcctta
      841 acaatatctt tgaaaggaat gatttcgaca ttgacaggca taaccgttgc aatagctggc
      901 aggaagtaaa ttgagagtgc attggtcatc aaatccagcg cagcagtgtt attggtcaaa
      961 agatagacag gtatcggtga caaatatgtt tttaggagtt cctctaactg tatcgtgaag
     1021 agcagtaaat gataggacgg cagtttcccc acgatacctt ctgcgctcat ccattcctca
     1081 acgatggttt ttagagtatt gtagaagctc ttgtttcgtt tttgctgtct tctgaggtaa
     1141 tggaacaagt gtatatcagg taacaaaact tgaagattac tgataaagag acgtgagaag
     1201 gaaaccaaaa tccgtttgaa aggaagggag tttaggatat tatcgcttag tagtggacgc
     1261 agggatgctt tcaaggtttt tccatttgtt tttgtcatca ccaactcaaa caattctttc
     1321 acttttttag gtgtccattt atccttatgg aaaggattat tggtggtgca aaaacataag
     1381 aaaatataat ccaaatcctc atcagttaaa tcaggatggt accattttcc gatgatttcc
     1441 tgactggtca ttttgatatc gtgatagata gacagttttt tcaagtgttt gaatgcatct
     1501 gtctgaggaa tacccaagtt atcatgtcgc cgtttccata taagggatat cagaatggca
     1561 aagtatgaaa attcataagg ggctttactg gcatcattaa gtgtgatggc ttgattggag
     1621 tttataatca gcgaaaccac tttattcatt gatgttttat caaaatcata aatggtcata
     1681 ccaaactgat agtgcaacaa ggcgatcaga aagcggatac ggtattctgg tccaacaaca
     1741 tggttttgcc gaacgtttaa acctaccttt ttcaagtatt tccgacaatt ggtcctgata
     1801 cggtaagcgg tggcttggga aatatactct cgtttaatga agtcgtgtag gctcagctct
     1861 cctggttcaa ttaaaaaaca taacatcttt aagaatatcg aggtttgata gagtttctta
     1921 aaataaggca ttttaagttg gtaggtctta taggggatag aaacagtgtc gtcacaaatg
     1981 gttaaggtga gggtgtcttc taaatcctta atcatttcaa tgagtaagtt gtagacacgt
     2041 tgttttttga gttcggtttc ctgacacaac tggtctatgg agacttcgga aacgtctaac
     2101 aaaatgttga gcagtgataa tttatcttgt aatttggttt ctagatgaag gtgtaacata
     2161 actgaactcc tttcattttt atagcagaaa ctcgtattta tttaattatc acataattaa
     2221 ataaaacagt caaataattc aatggtgacg cgtgtttaag gagtattgag aatgtcagat
     2281 ataagcaaaa tgcagctgaa tattcttaat tttaggtatg aaaaagcgtc gggattgata
     2341 aaaaatctat tgaatttggt aaatttaagt tgatataata agttgattag aaaaattaat
     2401 aattcattta aattctaatc agctgtaacg ttccggggcg tgttaaactg tctgaacata
     2461 gaaaatacag gtttctaaga tgactaaaat aagttaagga ggattcctta aattctgtga
     2521 taggaacgta aactctctac aagcgtagag cacgtcatca gtcagtctgg gtgtctactg
     2581 gctgacaacg tcaaataaga taggcatgaa aaaataaggg ggaacacaga atgtttttaa
     2641 aacaccacga tgtgaaacaa aaaaattgga gaatgcgtaa ggtcaaaaaa gtctttgtta
     2701 gttcatgtat gcttttaaca gtgggcctcg gagttgccgt acctactgga tttagccaat
     2761 ctaatggcgt gatggttgta aaggctgcgg aagctgaaga gaacctattt gcattttcag
     2821 atgataaatc aggaataagc cttctgtctt ctaagaaaca cataggtaga tattttgcaa
     2881 cgactacaga tgagtacact aacttttcaa aattttatgt acaagaaagc cacacgagtt
     2941 atcaaaacaa atgggttaac cactatgtta cagcaaataa tcctgggaaa aaagatgatt
     3001 ctcaaatttg ggctggcagt gatggtactg caaaaataaa attcttaaat gtttttaagg
     3061 attctaaaag agcaaattca ttagcactta gaatcaatac taaagaagtt caaaatggtc
     3121 ataagtattt aatggaagtg actgaaacta atacaggaca agttaagact gattatagaa
     3181 tatctgcggc ttttgatggt tcgcccagtt ccatcggtat taatttaaaa gataccgaga
     3241 aaaaaaaggc atctaatatt actttttcag atggtaatgg tgcttcatta aatcaaggat
     3301 atgaaaatcg taaatcagga aaaagagtat taacttttag atcaaatgta gatgaagcga
     3361 tttctcttac agttattgct agtgttccag atattccaaa tcgtgaagga gaagttagtt
     3421 tatctaaaat gaaagtaact gatatcactc ctgctccaat agttaatttg aaggctgatg
     3481 tagatacgca gagcaaaaaa gtaagtgtta agttggaaga tgagaacaga aaaaactttg
     3541 ttggtgatga aattcaagta tacagattaa caccggaagg cacacaggaa ctagttggaa
     3601 aagttactgt aagtcataaa aatagtaatt tagtggatat acctttggat agtgaaaaac
     3661 ttattgacaa cccgttaaaa gttaatgaga gattggtgtt taaaacagtc caaaaacact
     3721 caaaaaaaac caatgataag gctggagaag ctgtagttaa gttatctgaa tcaatagttc
     3781 aagaacaaga aaaagctcag attcagttga aaaaagttta tgaacagaca aaagagtcta
     3841 taaaaactga caaatggcta cctgctacta aaactgaaga tgttaatctc cagaatacta
     3901 ataaagaaac tcaattagct ttgcttgaag agcgatatga ggaagctcaa aaagctatta
     3961 aagatgcaat aactacggaa aagattactg aacaactaaa aaaatatgct tctgttggtg
     4021 acaaggagac atatcctaat tctttaccta atcaacatgt aaaaggaaac aaagctcaag
     4081 aacaacaaaa agctaaagaa gaccttacca agcttcataa ggaaatagag aaaaaaatta
     4141 cagatgatcc atggttaacg gaagaagcta gaaagcaaca attagctgct gagaaaaaag
     4201 cttttgctaa gggaaatcaa gctattgaag gagcacaaaa tctaacttca ctaagagaag
     4261 tcgttcaaca attttctgtt gatgaaaaag gtgctgaaga aaagaaacac cctgattcac
     4321 tacctaatca gtatatcccg gctgatgaac aggcgatcaa aatggttaaa aaaacatcac
     4381 ttaaagagtt acgtgatata acagtttcag ctatccaaaa ggatttatgg ttaacaccag
     4441 aggaaaaaat caaacaaata aaacaggctg atgaagcatt gaaaaaagga gaagtatttg
     4501 ttgagaactc acaaaatcta aaagaacttg aagacggact taaaaattac atcattaaag
     4561 ataatcgaga tgagtctatt cctaacaagt atcaagctgg taagaaggat gaattaacaa
     4621 ataaggctga agttaaactt aaggaagctc acgaagctac taaacaagca attgaaaaag
     4681 atccatggtt gagtccggaa cagaaaaaag ctcaaaaaga aaacgctaaa gcaagattag
     4741 atgcaggttt gaaagctgtc gaaactacag aaagcttaga taaacttaaa gaagttgaga
     4801 gtgacttcct tgataaagaa aaagcagaat ctattccatc tcaacatcaa gcaggaactc
     4861 ctgaagttgc tcgcaaaact ttcttagata actttgaaaa agaagctcaa aaagaacttg
     4921 aatcaattaa aaatgacgtt acattaacag atgctgaaaa agcaacagct aaagctaaag
     4981 tagaagcaca acttcaagaa gctaaagata aggctaagga atcaaaatcg tttgatgatt
     5041 tgaagaacat tcaagataag ttcaattctg aattaccaca cacaccaggt aagccgctta
     5101 aagatcaaca atctgatgct attgcagaat tagagaagaa gcagcaagaa attgaaaaag
     5161 ctattgaggg tgataaaaca ttaccaagag acgaaaaaga aaaacagatt gctgactcta
     5221 aggaacgttt gaaatctgac acgcaaaaag ttaaagatgc taaaaatgct gatgctatta
     5281 aaaaagcatt tgaagaaggg aaagtgaata ttcctcaagc acatatccca ggtgatttga
     5341 acaaggataa agaaaaactt cttgcagagt tgaagcaaaa agcagatgat actgaaaaag
     5401 cgattgattc cgataaaact ttgacagcga aagaaaaaga agagcaaaaa gcgaaaacaa
     5461 aagaagaact tcaaaaagca acagaagctg ttggagcaat tgacaatcgt gaagaactag
     5521 ataaaaaagt tccagaactt aagaaagcta ttgaagacac tcacgttaaa ggtaatcttg
     5581 aaggtattaa gaataaagct attgaagatc ttaaaaaagt tcatgacgaa acagttgcta
     5641 agataaatgg tgatgatacc cttgacaaag ctactaaaga agctcaagtg aaagaagctg
     5701 acaaagcttt ggcagcaggt aaagatgcga tcactaaagc agatgatgct gataaagtaa
     5761 gtacagctgt tacagagcat acaccaaaaa ttaaagcagc acataaaact ggtgacctta
     5821 aaaaagctca agaagaggct aacacagctc ttgacaaagc agctgaaaaa gaacgtgaag
     5881 aaatcaataa tgatatcaca ttaacggcaa aagacaaaga acaacaactg aaagaagttg
     5941 agacagctct tactaaagct aaagataacg tgaaagctgc taagacagca gacgctatca
     6001 atgacgcacg tgataaaggc gtagcaacaa ttgatgccgt ccataaagca ggtcaagact
     6061 taggtgctcg taagtcaggt caagtcgcta aacttgaaga agcagctaaa gcaacgaaag
     6121 acaagatttc agctgatcca actttgacaa gcaaagaaaa agaagagcaa tctaaagctg
     6181 ttgacgctga acttaagaaa gcgatagaag ctgttaacgc agctgacaca gctgacaagg
     6241 ttgacgatgc tcttggtaaa ggtgtcacag acatcaagaa ccaacataag acaggtgacc
     6301 ctgtcgaagc tcgtcgtgga ttacacaaca agtcaatcga cgaagtggct caagcaacta
     6361 aggacgctat cacagcagat acgactttga ctgaagccga aaaagaaata caacgtggca
     6421 atgttgataa agaagcagct aaagctaaag aagaacttgc taaggctaaa gatgctgatg
     6481 ctttagacaa agcgtacggt gacggtgtca cagacatcaa gaatcaacat aagtcaggtg
     6541 accctatcga agctcgtcgt ggattacaca acaagtcaat cgacgaagtg gcgcaagcaa
     6601 ctaaggacgc tatcacagca gatacgactt tgactgaagc cgaaaaagaa acacaacgtg
     6661 gcaatgttga taaagaagca actaaagcta aagaagaact tgctaaggct aaagatgctg
     6721 atgcgttaga caaagcgtac ggtgacggtg taaccagcat caagaaccaa cacaagtcag
     6781 gtaaaggtct tgacgttcgt aaagatgagc acaagaaagc tcttgaagct gttgctaaac
     6841 gtgtcactgc tgaaattgag gctgatccaa ccttaacacc agaagtgaga gaacaacaaa
     6901 aagcagaggt tcaaaaagag cttgaacttg cgactgataa gattgctgaa gctaaagatg
     6961 cagatgaagc agacaaagct tacggtgacg gtgtcacagc gatcgaaaat gcccatgtta
     7021 ttggtaaagg tatcgaagct cgtaaagacc ttgctaagaa agaccttgct gaagctgttg
     7081 ctaagacaaa agctctcatt attgaagaca aaacgcttac tgatgatcaa cgtaaagaac
     7141 agttatcagg tgttgataca gagtatgcta aaggtatcga gaatattgat gcagctaagg
     7201 atgctgcagg tgttgataaa gcatatagtg atggtgttcg tgacatcctg gcacagtaca
     7261 aagaaggaca aaaccttgat gatcgtcgta atgctgccaa agaatttctt cttaaagaag
     7321 cagacaaagt gacgaaacta atcaatgatg atccaacctt gactcatgac caaaaagttg
     7381 atcaaatcaa caaagttgaa caagctaagt tagacgcaat caagtctgtt gatgacgctc
     7441 aaacagctga tgctatcaat gatgctcttg gtaagggtat tgaaaacatc aacaaccaat
     7501 accaacatgg cgatggcgtt gatgttcgta aagcgactgc caaaggcgat cttgaaaaag
     7561 aagctgctaa agtgaaagct cttattgcta aggatccaac cttgactcaa gctgataaag
     7621 acaaacaaac agcagcggtt gacgcagcta agaacacagc aattgcagcg gttgataaag
     7681 cgacaacagc agatggtgtt aaccaagaac ttggtaaagg catcacagct atcaacaaag
     7741 cttaccgtcc aggtgaagct gttaaagcac gtaaagaagc cgctaaagct gatcttgaaa
     7801 aagaagctgc taaagtgaaa gctcttattg ctaaggatcc gaccttaact caagctgata
     7861 aagctaaaca aacagcagcg gttgacgcag ctaagaatac agcaattgca gcggttgata
     7921 aagcgacaac agctgaaggc attaaccaag aacttggtaa aggcatcaca gctatcaata
     7981 aagcttaccg tccaggtgaa ggtgttaaag cacgtaaaga agccgctaaa gctgatcttg
     8041 aaaaagaagc tgctaaagtg aaagctctta ttgctaagga tccgacctta actcaagctg
     8101 ataaaggcaa acaaacagca gcggttgacg cagctaagaa tacagcaatt gcagcggttg
     8161 ataaagcaac aacagctgaa ggcattaacc aagaacttgg taaaggcatc acagctatca
     8221 ataaagctta ccgtccaggt gaaggtgtta aagcacgtaa agaagccgct aaagctgatc
     8281 ttgaaaaaga agctgctaaa gtgaaagctc ttattactaa cgacccaacc ttaacaaaag
     8341 ctgataaagc taaacaaaca gaagctgttg ctaaagctct taaagctgct atcgcagcgg
     8401 ttgataaagc gacaacagct gaaggcatta accaagaact tggtaaaggc atcacagcta
     8461 tcaacaaagc ttaccgtcca ggtgaagctg ttaaagcacg taaagaagct gctaaagcta
     8521 atcttgaaaa agtagctaaa gaaactaaag ctcttatttc aggagaccgt tacttgagcg
     8581 aaactgaaaa agcagtccaa aaacaagctg ttgagcaagc tcttgcgaaa gcacttggtc
     8641 aagttgaggc tgctaagaca gttgaagctg ttaagctggc agaaaacctt ggtactgtag
     8701 ctatccgttc agcatatgtt gctggtttag ctaaagatac tgatcaagca acagctgctc
     8761 ttaacgaagc gaaacaagct gctattgaag ctcttaaaca agctgctgca gaaacacttg
     8821 ctaagattac aactgatgct aaattgactg aagctcaaaa agctgaacaa tcagaaaatg
     8881 tatcattagc gcttaagacg gctattgcga ctgttcgttc agcacaatct attgcgtctg
     8941 tgaaagaagc aaaagataaa ggtattactg ctatccgtgc agcctatgtg cctaataagg
     9001 cagtcgcaaa atcatcgtca gcgaaccatc ttccaaaatc aggtgatgca aactcaattg
     9061 ttcttgttgg cttaggagtt atgtctcttc ttttaggtat ggtgctttat agcaagaaaa
     9121 aagaaagtaa agactaagaa cctggcttta tccaaattgc tttctactat attttcaaac
     9181 caaggtgatt ttgaaatcac cttggttttt tggatcgtaa gggcccaaga acggagtgta
     9241 ttgaaaacat ttcaaagttc aattgaaaag gcaacagttt tctgtacaga atttataagg
     9301 cgttttttgt tcaaacgatg actcatttag ttatgggtgt ttgataatta agattactgt
     9361 gaaggtgatg gtagttccac cagtggactt cctccttggt tttaagggtt aattgttcta
     9421 gtgaataaaa ggtttcttgg tcgcgcagta gggatcaagc gagcagataa aatacctatt
     9481 ttaaatcagt tcgagcgaat tttcgtgcta caagctcaaa agaggctact aaagtattag
     9541 aatagtttat ctctgagtga agttcttgtt ataagaagat gatgttatcg tttgaaacga
     9601 ccaaaaaatc tcctaacttt tactaatttc tacatgaaat ctagtccagt atttactcta
     9661 caaccttgat tgattcgctt aataaagaca tttctacttg attgtttaca catagttatt
     9721 gatagaatct attataaaat tcagtatatt atataataat tgtttctata ttaataaatc
     9781 attatttttt tgtcattttt gataatatta aaaagaaagg gtttacatat taatcatttt
     9841 ttactataat aaaagtgata agaactagat agttgttgtg ttacaacagt acaattgagc
     9901 tagccttgtc cttgttgtgt taactttatt tttaaaataa ggttaaaaat aaacgactcg
     9961 tgttcttatc agttacttat tagataagga ggtaaacctt atgttaaaat ttacttcaaa
    10021 tattttagct actagtgtag ctgaaacaac tcaagttgct cctggaggct gctgttgctg
    10081 ctgtactact tgttgcttct caattgctac tggaagtggt aattctcaag gtggtagcgg
    10141 aagttatacg ccaggtaaat aatctattta gcatctctat gtgatagtga tattaaggta
    10201 atgagtttgc tagcaactaa gttatctttg gtaacttctg attatagatg aatggcatag
    10261 aggtgttaga aaacatgaga caaaagtaat cttcttgatg ctaacgtctc aggtaattag
    10321 caggtactag acagtacctg ctaattacta tatgtttagt aaaatgagat aggaaagata
    10381 gttatgtcat tttttacaaa ggaacaacaa cctaaagaga attgtccgcc aataactgtt
    10441 gaaaaagcaa ggcaattgtt tgaatttaat acaaaccact tgtccttatc ggattaccat
    10501 catcaaacgg tgctaaaaac gtcaaagcag ctagttgctc aacatttaat gcctaatgca
    10561 accgataatc ttagtcaaca ttttttgatg aactataaag ctaataataa ttatttaggc
    10621 ttccaagcta gtattgtcga cttttttaca gattctgccg ttgctaattt ttcaagtagt
    10681 tacgtttatg aaagtcagga aaagataatt cgtttaccaa aacctaccaa gatatcaact
    10741 gctctgtcga catgtattat aaaacgaaga agtcatcgtc aattttcaga tagacaaatg
    10801 cctcttcaag atttatcaaa cattctttat tatgcatgtg gtgttagttc acaagcatca
    10861 attagagatg gagcatcaga taagattaca ctcagaaact gtgcttcagg tggaggttta
    10921 taccctattc atttagtttt ttatgctaga aacatcagta aattaataga tggtttctat
    10981 gaatatctac cctatcagca tgcactaagg tgttatcggc atagctctga ggaaaacgtt
    11041 agagattttg cggaatacgg tgctattaat gctgaaaatt gtaatattat tattatttat
    11101 gtctaccatt acatgaaaaa tacacgtaaa tatgggaatc aggcgactgc ctatgctttt
    11161 attgaatcag gagaaatagc ccagaatatt caattgactg caactgcctt aacttatgga
    11221 agtattgata ttggtggtta taataaggaa tatctccaag aattattaga tttagatggg
    11281 ctaggagagc atgtgattca catgacactc gtaggaacta aggagtctca atgaaatatc
    11341 aacttaatag taatgttcgt gtcgtgacat ttcaagatac attttgtttt agaaaaggaa
    11401 tctgggactt taatgaagcc attctagatt tgacacaaga acctcaaaat ttaaagatag
    11461 tttatcaaga aataatttca cagttggtta agggagtagc cattgatact gaaacttatg
    11521 aaaatacttt agaacctgag acgttcgcta atttaatgga agtcatttca ggcttgtatt
    11581 acaatgatat gctgatgctt gaggatgact acaatcttga agaaaatgtc atgaaaattt
    11641 taatgggtaa tttccgtttt atggcgcaag caggtcatat ggtaagcaat gatcctgttt
    11701 tgtttatcag tgattcgact tatgttaatg aatctgctga gttgctagct gaacaactgc
    11761 atttacaatt gcaagtggct agcgatgact taaaaatgtt aattcagcag acagatgtta
    11821 gttcgcgttt agatgctttg gagcatcgcc gtaacatgaa ttgtttatca gaagccttgt
    11881 gcgattacca aagtattatt atttgtcaag aacgcttgaa tattatgatg ttgcgacact
    11941 tgaatgaagt tagcgtagct atgaaaaaac aattagtgat tggttttgta gatggaccat
    12001 tcttgcacac ttgtactttg aatcctcctc atagtgctga ctttgatagc ttagaaagaa
    12061 gagttttggc acgtttacaa gactcaactc tctatcaaca ttttgctaat caggttttac
    12121 cagcaacaca agatgtgagc caggcctatt taccattgtt aaatgtttta atgaatttag
    12181 tcgttagcga agctttcatt attgctcaaa caggtagttc taaatttgag ggacgtttat
    12241 taagcattta cttaccgacg cttgagattc aggtccaaga tattttgaaa atgtctaatt
    12301 cacagacaca aggagctttg gcaaaattaa agtatgagga tcagcagata tcaacacgtg
    12361 agattgttaa aaaactcctt gacgagtaac ctataaggag aacctattat gttatactat
    12421 tatccttctt ttaatcatat ttttgatgaa ttaaaaagtt taagtggcaa tcgaacaggt
    12481 atcttaaatc aatctcaagt tccagtttgc aaccatcctc acgatgttta cttaaaaagt
    12541 attactggcc aaatgccaga ttatcataaa caatttatag gtgagttgag tcaagttagt
    12601 tatcacatta ttggttacgg cagttactac gaagaagcac ttatcaagta tttaggagaa
    12661 agtattgaac gctatgctac tgtaattgcc ggagacttac tatcagatcg gattgtctat
    12721 gcttcttata atgagttaaa actgttacat aaagtgatgc ctttagaata cttgcaagtg
    12781 tttacccaag aacagatcgc attatcttgt gacttgcaaa tgatgatgtg cgataaaatg
    12841 gtaactgaga acgatgtatt gggctgggtt aaatgtccca tgttctttga ggacgcagag
    12901 atgtatgttc cagctcaaat gctttgtgtt gggtataaaa caaatgagac tgtaggagaa
    12961 agacggataa taccaggatt ttctacggga acagcttctc acaaaacgtt agaagcggct
    13021 atgtgcaaca gtttgattga atacatccag atcgattcaa tgatgcttag ctggtatact
    13081 aagaagcctt gccccaagat tattgttgat gatcctgata ttgaaatgat tttagaagaa
    13141 gctagactgg gaaaagacag tctatacgac attattccta tcgatatgac tgtaggagaa
    13201 gataatcctc tttatacgtt tggaatcatt ctcaaaaata aatatgatga agggccttac
    13261 ctcttgtttg gagtgcaggc tgggttagat cctaaacatg ctttgctaag agggatcatg
    13321 gaagcttcag ctattagcta tagttactac tataatcttt tatatcaaaa agcttccctt
    13381 gcaaatattg aatgcgaaga acctttgttt ttagatttag atagtaatgt tttctattat
    13441 gcacatccca aggaccaaga ccataaatgg aaggcctttg aacctttgat ttcaggagaa
    13501 gttctgttaa gtgatttgga agatcattct ggtaaagata aaaaagaaga tttgaagact
    13561 ttattagctt atgctaagaa agtcagtcct aatgctgtct ttttagatat tacacctcct
    13621 gaagctctag aaaaaggctg gtacgtcacg cgagttctga tgccagaact tcttgaaatg
    13681 tgtataccag catttccttt tgctaatcac ccacgaatga gacagtttgg aggtgtaaca
    13741 aatgcctttg tccatccaat gccttaatct ttgttttttg ctggtaactt tttgtccttc
    13801 aattcctatg caagctattt ttggaaagga agatagtggt tatgcattta atttaattgg
    13861 ttttctaaga gcaactctga tttatgacat tttggctttg gtaagtattt atgttttgtc
    13921 acctcaaata accttgtctc ttgaaagtat tgatagtaag acgttcttta tgggacttgt
    13981 attttgcgtc tttatagtac tgattgaact cgttttctta catggtttac gttgttggca
    14041 aaaaaagcaa tggcttcctg caactttctc gtttgtagga acgacaaatg attggtctaa
    14101 gattggctat cctttattac tagctttatt tgaagagacg atttatcgtt ttttgtggtt
    14161 taatatatta gcttttcaat ggcatttacc aacaattatt gttttaattg taactagttt
    14221 ttgctatgct ttaaatcact tattgatggg gaaatccatt ttttatgcta agttggtaac
    14281 aggcatcatt tatggtagta tttacatgct gactagtcaa ttgtggttgg ttgtgataat
    14341 gcatgtagga ggtaacttgc tagttgagtg tcttagccat cttcaaacaa aaaagaagaa
    14401 ggaggtgaca tgatgctatt ggttttgctg tcgtttttag gtctaactac tctttggttg
    14461 accagttatc gaagacgttg tttggctaga tggcatcttc aatggttaat ggccttatcc
    14521 tatcaagatt ttttagatgt cttactgagt ctgtttcaat ttgtcgttat tatacttgtt
    14581 ttgttctttt actcagctac tattaatcta ggagaggttc tgaccttttt gacacaaact
    14641 agctggcatt ggcagattct ttgttattta gtgttgtatc ttatggccat catagagatg
    14701 acgcttttag ttttaattct tatctttgat gttttgctcc agaaagatag tcgattgctc
    14761 tttaaaaaaa taacttggct gccttttaga caagataaac cagtcttaag tatacttttg
    14821 ctaggcatag ttattctagt agacagtctc ttttatttgg gcttgcttat attattagga
    14881 gaacagtcgc taacaagttt agcaacgctt attttaggct atgggatagt caaggcttgt
    14941 cgctattcag gttggttaaa tgtactatta gctttttgtc ttttcactat agttggacta
    15001 tgggcagtta cggcaacttt attatatggt tggctagtag gtgcgatgat attaacggtg
    15061 acttatttga tgattagttg caaagagtat tagcaatatt aaaaaggagt gatatatgag
    15121 ttttgtacaa ttaacaaatg ttgtcaagtc ctacaaaaac ggcaagaaag ctgtcaatga
    15181 tgtttccttg tctattgaag caggtaatat ttatggtttg ttaggaccaa atggtgctgg
    15241 taagtctacc ttgattaatc ttatcttagg cttgatccct ttgagttccg gtaaaattac
    15301 tgttttaggg caatcccaaa agactattcg aaaaataagt tcgcagatag gttatgttcc
    15361 tcaagacatt gctgtttatc cagacctaac tgcttatgaa aatgtagaac tatttgggtc
    15421 actttatggc ttaaagggag ctcagcttaa aaaacaagtt ctaaaaagtt tagaatttgt
    15481 gggactacac tcccaagcta agcagtttcc aagtcaattc tcaggaggaa tgaagagacg
    15541 gttaaatatc gcttgtgcgc tagttcattc acctaaatta atcatttttg acgaaccgac
    15601 tgtagggatt gatcctcaat cacgtaatca tattttagag tcgattcgtt tgctaaacaa
    15661 agaaggtgcc acagttattt atacgaccca ttatatggaa gaagtagagg ctctttgtga
    15721 ttatattttt attatggatc atggtcaagt tattgaagaa ggacctaaat ttgaactgga
    15781 aaaacgttac gttgcaaatc tagcaaacca gattattgta actctaacag attcacgtca
    15841 tttggaactg gcagataagc ctgattggtc tttgatagaa gatggagaaa aactcatgtt
    15901 gaagattgat aatagtgata tgacatcagt tgttcatcag ctcacacagg ccaatattac
    15961 ttttagcgag attagacata accatttgaa tttagaagaa attttcttac acttaacagg
    16021 taagaagtta cgagattaga ggttactatg gttttatttc atttaatcaa aaaagaaagt
    16081 ttacagattt ttagaaaccg aacagcctta ttgatgatgg tgatttttcc aattttgatg
    16141 atcgttattt taagttttgc ctttaaatca agttttaata ctgcgacaac agtccctaaa
    16201 ttgaccattc gttaccaatt agagggtgaa aaaacggatt accagaaaaa ttttcttgct
    16261 tttttaaaag ttttaaacca aaaacttcat ttagaggcta aacctagtaa ttctcttgaa
    16321 aaagatcgac aaagggtcag tgaaggagcc ttaacggctg ttttagaagt gaagaagaat
    16381 cagaccatta aggttattac taataatatt aatcagcaaa atgcagattt gatcaatatg
    16441 ctagtaaaaa attatgtaga taatgctaaa acttatgact cgatagcagc tctttatcct
    16501 caacaattaa atcatatcag aaagcgaagt gtggactatg ttaaggtcag ttcaatacag
    16561 acaagtaaag gaatgacatc agctgattat tatgctattt ccatgtttac catgattact
    16621 ttttatagta tgatgtctgc gatgaacctt gttttgtcag atcgtcaaca acggattaca
    16681 aatcgtattc acttaacagg agtttctcca agtcttttgg tccttggaaa attaataggt
    16741 gctatgttag caacaactgt tcaattgagt cttttataca tttttacaag gtttgtttta
    16801 cgagttaatt ggggcactaa tgagtggatg cttattggta taacagcctc cttagtctat
    16861 ctctctgtag ctataggtat cgggctaggc ataagcatta aaaatgaggc ttttttaacg
    16921 gttgcatcca atactattat tcctatattc gcctttttag gaggcagtta cgttccattg
    16981 acaacattac acagctctat tattaatcaa ttgtcgaata tatctcctat taaatgggtt
    17041 aatgatagtt tgttctatct tatttttggt ggtcaatata atccgattcc tgtaactttg
    17101 atcgttaata ttagtatcgg aacaattttt ataatattgt cattgatagg tatgagaaag
    17161 caggtgacga catgatttgt tttataaaaa ctctatttgt taagataaag cgcaaaaaaa
    17221 caagttatgt gacattcttt ttaatgccta ttttaacgac acttttggct ttatctttga
    17281 gtttttcaaa taataatcag gctaaaattg ggatattaga taaagataat agtcagatat
    17341 ctaaacaatt tattgctcaa ctaaagcaaa acaaaaagta cgacattttt accaaaatca
    17401 aaaaagagca tattgatcac taccttcaag ataaatctct agaagcggta ttgactattg
    17461 acaaaggatt ctcagataaa gtgttgcaag gaaaatctca aaaactcaat atacgttcga
    17521 ttgctaatag cgaaattaca gagtgggtaa aggcacagac caattatcta ttggaaaatt
    17581 ataatattat aggggatgtg gctctaggta acgaagatac ttttaataga attctccaaa
    17641 aaaaccaaca gttaaattat gatgttaagc aagtaacttt gacagaccga tcacgtagca
    17701 aagcagtatc ttccacaacg acaggatttt tgcttattct aatgttaggt agtacgagcg
    17761 tgatttacag tggtattttg gcagataaat ctagtcagtt ataccatcga ttaatgttat
    17821 cgaacttatc tcgttttcgc tatatgttga gttacgtctg tgtaggattt gttgctttta
    17881 cgattcaaat tgtcattatg ctgagtttgt taaaagtatt taatattagt ttttttgttc
    17941 cgacatcact tcttttgatt atttttttcc tttttagttt attagcgata ggctttggcc
    18001 tgctggttgg agctatcaca caaaattccc aacaaagtag ccagttagct aatcttattg
    18061 taatgccgac ttcaatgttg gctggctgtt tatggccatt gtctattacg ccttcttata
    18121 tgcaagcaat tggtaagtta ttaccacaaa attgggtttt atcagccata gctatttttc
    18181 aaagtggagg gaccttatct caggcttggc catacttgtt agctctaatg ggaacagcac
    18241 tagctttgat tattttttca agtttattat taaaacctac cagactataa ttagtctttt
    18301 gttaaaaaat actttcctaa ttagctaact accaggtagc ccttttattg gcttatatgc
    18361 aataaaaggg ttgctttttg cttatatttt ctctagtgca cttatctttt gttaaaagcg
    18421 attgcgatgt tactgttgtt actgtgtttt ttagagagca tattatcaaa agcgacctct
    18481 ctagaaagtt cgtttttgtt gataaatgag ttgtcaaagt attttaaaaa acgttttcga
    18541 taaacataaa aactaatgtt attaaaaaaa ggtgtaaaaa cgtatttatt ttatgaaatg
    18601 tttttgttac aataagcatg tatcgaatgc tataaagctg tcttgttcgc tatcaggggt
    18661 gcttgtgatg ttatgtcaga tcaaacaagt ctttaattgg gtgacttaac agattaaaag
    18721 aaaagatcta atcgtgttac ttgatagtat aattaatgca aacagaaagt gtatcccaat
    18781 tcatagtctc aggtggaggt taatattcaa aaataaaatc ttgttgttgt cttaaactaa
    18841 tcacattaaa aggagatatc atgattaaca agaaatgtat aatacctgtt tcattgttga
    18901 cactagctat tacgcttact agtgttgaag aagttacttc acgccaaaat ttgacttatg
    18961 ccaatgaaat cgtaacacaa aggccaaaga gagaatctgt tattagtgat aaatcgaatt
    19021 ttcccgtcat atcaccttac ctagcaagtg tggattttgg tgagagaaaa acacctttgc
    19081 caacacctga taaaggagta aaagtaacta ctgaacagtc tattgctcaa gtaagaaagg
    19141 ggcctgaaga aagaacctat actgttactg gcaagattac gagtgtgatc aatggctggg
    19201 gaggctatgg cttttatatt caagatagtg aaggtattgg actttatgtt tatcctcaaa
    19261 aagatttagg atacagtaag ggagatattg ttcaattaac aggcacactt actcgcttta
    19321 aaggtgattt acaactccaa caggtgactg cacacaaaaa gttagagtta tcttttccga
    19381 cttctgttaa agaagcagta atatcagaat tagaaacaac aacaccctca acattagtta
    19441 agttatctca cgtgacagtt ggagaattat caactgatca atataacaac acatctttcc
    19501 ttgtaaggga tgatagtggt aaaagtatag ttgttcatat agatcatcgt acaggggtta
    19561 aagggactga tgttgttact aaaataagtc agggtgattt gattaacctc acagccatat
    19621 tgtctattgt tgatggtcag ttacaattaa gaccgttttc tcttgaacaa ttggaagtgg
    19681 ttaaaaaggt cacaagctca aatagtgatg cttcatctcg taatattgtg aaaataggcg
    19741 agattcaagg agctagtcat acgtcgccac ttctcaaaaa agcggtcacc gtagaacagg
    19801 ttgttgtcac ttatttagac gattccactc atttttatgt tcaagatctt aatggtgatg
    19861 gtgatttagc gacttcagat ggtattcgtg tttttgctaa aaacgctaag gttcgagtcg
    19921 gcgatgtttt gaccatttca ggtgaagtgg aagaattctt tggtcatggt tatgaggaac
    19981 gtaagcagac tgaccttacc atcacccaaa ttgtggctaa agcagtgacc aaaacaggga
    20041 cagctcaagt tccatcaccg cttgttttag ggaaagatcg tatcgcgcca gccaatatta
    20101 ttgataatga tggcttgcgt gtgtttgatc cagaagaaga cgctattgat tattgggaat
    20161 caatggaagg catgttagtg gcggttgatg atgctaaaat ccttggtcca atgaaaaata
    20221 aagaaattta tgtcttacct ggctctagta caagaccgtt aaataattca ggtggagtat
    20281 tacttccagc taattcttat aacacagatg tgattcctgt tcttttcaaa aaaggcaaac
    20341 aaattattaa agcaggagac tcttacaaag gaagattagc tgggccagta tcttatagct
    20401 atggtaatta caaggtcttt gttgatgaca gcaaaaacat gccaagttta atggatggtc
    20461 atctaaaacc tgaaaaaaca aacttgcaaa aagaccttag caagttaagc attgcttctt
    20521 acaatattga aaacttctca gccaatcctt cttcaactaa agatgagaag gtcaaacgga
    20581 ttgccgaatc ctttattcat gatctgaatg ctccagacat tattggatta attgaagtcc
    20641 aagataataa tgggccgact gatgatggga caacggatgc gacacaaagc gcacaacgcc
    20701 tcattgatgc tattaaaaaa ctaggtggcc caacttatcg ttatgttgat attgctccag
    20761 aaaataatgt tgacggaggt caaccaggtg gtaatattcg aacaggattc ctttatcaac
    20821 cagagcgcgt cagcctttct gataagccaa aaggcggtgc tcgtgatgct ctaacttggg
    20881 ttaatggaga attaaacctt agtgttggtc gaattgatcc aactaacgcc gcttggaaag
    20941 atgttcgtaa atcactagca gcagaattta tcttccaagg tcgtaaagtc gttgttgttg
    21001 caaatcattt gaactctaag cgtggggata atgctcttta tggtcgtgtg caaccagtca
    21061 cttttaaatc tgagcaaaga cgtcacgtct tggctaatat gctagcacaa tttgcgaaag
    21121 aaggggcaaa acaccaagct aatattgtga tgctaggtga ctttaatgat tttgaattca
    21181 caaagacgat tcaattaatc gaagaaggtg atatggttaa cttggtgagc cgacatgata
    21241 tttcagatcg gtattcttat tttcaccaag gcaataatca gacccttgat aatatattag
    21301 tttcacgcca tttacttgat cactacgaat ttgacatggt tcatgtgaat tccccattta
    21361 tggaagctca cggacgcgca tcagatcatg atccattgtt acttcaatta tcattttcca
    21421 aagaaaatga taaggcagag tcttctaaac aaagtgtaaa agctaaaaaa acttcaaaag
    21481 gaaaactgtt gccaaaaaca ggagatagtc ttgtttatgt gataacgcta ctaggaacgg
    21541 ctagtttatt agtgcctatt ttattattga ctaaaggcaa aaaggaatca tagcgatttg
    21601 aagaattgga gttcataaag agtcgttaaa ggcttgatat acttacgtta gaccttaagc
    21661 taaaatggat gactatataa aaactaatat tgataacaaa agaagataac aataagacag
    21721 ctttacttgc taaagacttt tgtcaagcta attgttttat ggtacaatgt aaccgttgct
    21781 ttgcaaccct tggtgcttag ttccctttca ccaagcatat tagaaacgta gatagctttt
    21841 gagagttatc cagacgttaa aggagaaaaa atgacaaaat tgactgtaca cgactatgtt
    21901 cacattgggc tagtagctgc cttgtatgtt gtcttaacta ttaccccacc tttaaatgcg
    21961 atttcttatg ggatgtatca atttagaata tctgaaatga tgaatttctt agctttttat
    22021 catcgcaagt atattattgc ggtgactctt ggatgtatga ttgctaactt ttatagtttc
    22081 ggactgattg atgtctttgt aggcggcggt tcaactctta tttttgtgac cttaggtgtt
    22141 attttgttta gtaagtatca aaaagattat ctttttaatg gcatttttaa taaagctttt
    22201 gtttactttt ctttcttttt tgcaacttcc atgtttactg tagcaatcga actttacttc
    22261 tttggagctc catttttatt aacatggttt acaattgcgt taggagaatt agtatctctg
    22321 ctcataggat cacttattat tgataagttg tctcaaagaa tttcctttta gtaatgcatc
    22381 atactcaaaa gagttgggtc aatacccttc tcttttttat gttgtttgta atgttaaaat
    22441 cgttctagat agaaatattt aacactttag ctaatagtac catatggagt ggccaacgat
    22501 tacttttgat gttgttatga tatagaaata gctcatttgt tatcttttat gataaaataa
    22561 aagtatgaaa aaacgcataa aagaattaac agatcttctt aaccgttacc gttatgacta
    22621 ttatactaaa gatgccccat cagtttctga cagtgactat gataagcttt atcgtgaact
    22681 ggtgacttta gagcagtcat atcccgagta tgtcttgcaa gatagcccaa cgcagcaggt
    22741 tggagggact attttaaagg ggtttgaaaa atatcgacat cagtatccgc tttttagttt
    22801 gcaggatgct ttttcacgtg aggagctgga tgcttttgat aagcgcgtca aggccgaatt
    22861 tccgaatgcc acctatctag cagagttaaa aattgatggt ttatctattt ccttgagtta
    22921 tgagaatggc ttcttacagg ttggagcaac acggggtgat ggcaatatcg gtgaaaatat
    22981 cacagaaaat atcaaaaaaa taaaggatat tcctcaccaa ttgagtgagc ctttaaccat
    23041 caccgttcga ggagaggctt acatgtctcg tcagtccttt aaagcgatca atgaagcacg
    23101 ccaagaaaat ggggagactg aatttgctaa tcctagaaat gctgccgctg ggacactaag
    23161 gcagctagat acggcagtgg ttgctaagcg tcaactagcc acttttttgt atcaagaagc
    23221 tagtccgaca gctagaaatc aacaaaatga ggtcttagca gaattagcag atctaggttt
    23281 ttcagtaaat ccgtattatc aactcacatc gtctatggat gagatttgga attttatcaa
    23341 aactattgag gcaaaaagag atcaattagc ttatgacata gatggcgttg ttattaaagt
    23401 taatagccta gccatgcaag aagagctagg gtttacggtt aaagctccac gctgggccat
    23461 tgcttacaaa tttccagcag aagaaaaaga ggcagaaatc ctttcggttg actggacagt
    23521 gggacgaaca ggcgtggtca cacctacagc gaatctaact cctgtgcaac tagcggggac
    23581 aaccgtgagt cgtgcaaccc tacataatgt ggattatatt gccgaaaaag atatccgtat
    23641 tggcgataca gtgattgtat ataaggcagg ggacattatt cctgctgtct taaatgtcgt
    23701 tatgagtaag cggaaccagc aagaagtcat gcttattcct aaactatgcc catcttgtgg
    23761 tagtgaa
//
