LOCUS       NZ_CRAW01000006        22991 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptococcus pneumoniae strain SMRU702, whole genome shotgun
            sequence.
ACCESSION   NZ_CRAW01000006
VERSION     NZ_CRAW01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001193635.1-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 01:34:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,202
            CDSs (total)                      :: 2,158
            Genes (coding)                    :: 1,981
            CDSs (with protein)               :: 1,981
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 66 of 177
            Pseudo Genes (incomplete)         :: 114 of 177
            Pseudo Genes (internal stop)      :: 46 of 177
            Pseudo Genes (multiple problems)  :: 43 of 177
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:02:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5053
            Orig. end                         :: 28044
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CRAW01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22991
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22991
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12991](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12991
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(277..291)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
     gene            complement(834..2204)
                     /locus_tag="AK725_RS04345"
                     /old_locus_tag="ERS020212_00850"
     CDS             complement(834..2204)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /locus_tag="AK725_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00850"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_001036277.1"
                     /transl_table=11
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVGR
                     FLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWILGA
                     LLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLRSIG
                     DSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRKSVPE
                     LLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQSSVNTFGAVIISAQTAARR
                     IMTFALLPMTAISASMTTFASQNLGAKQPDRIVQGLRIGSRLSISWAVFVCIFLFFASP
                     ALVSFLASSTDGYLIENGSLYLQISSTFYPILSLLLIYRNCLQGLGQKILPLVSSFIEL
                     IGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAILATKVQS"
     gene            complement(2511..3677)
                     /gene="recA"
                     /locus_tag="AK725_RS04350"
                     /old_locus_tag="ERS020212_00851"
     CDS             complement(2511..3677)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /locus_tag="AK725_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00851"
                     /product="recombinase RecA"
                     /protein_id="WP_001085463.1"
                     /transl_table=11
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGER
                     AEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAA
                     FIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALV
                     PRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETT
                     PGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMY
                     GEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQV
                     RSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVTLDLGDELEIEIEE"
     gene            complement(3732..4988)
                     /locus_tag="AK725_RS04355"
                     /old_locus_tag="ERS020212_00852"
     CDS             complement(3732..4988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /locus_tag="AK725_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00852"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_000642705.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDN
                     EVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFA
                     LRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLN
                     QLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTK
                     ASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAA
                     AESLTAGLFQATVANFSGASSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQK
                     MAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADV
                     RHIAVMHAFNLVRKALLSD"
     misc_feature    complement(5014..5027)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     misc_feature    complement(5015..5028)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     gene            complement(5073..6089)
                     /gene="brpA"
                     /locus_tag="AK725_RS04360"
                     /old_locus_tag="ERS020212_00853"
     CDS             complement(5073..6089)
                     /codon_start=1
                     /gene="brpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /locus_tag="AK725_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00853"
                     /product="biofilm formation/cell division transcriptional
                     regulator BrpA"
                     /protein_id="WP_000239284.1"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     gene            complement(6097..6615)
                     /locus_tag="AK725_RS04365"
                     /old_locus_tag="ERS020212_00854"
     CDS             complement(6097..6615)
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /locus_tag="AK725_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00854"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000455535.1"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQAGGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLIG"
     gene            complement(6605..7048)
                     /gene="tsaE"
                     /locus_tag="AK725_RS04370"
                     /old_locus_tag="ERS020212_00855"
     CDS             complement(6605..7048)
                     /GO_process="GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /locus_tag="AK725_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00855"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_000288234.1"
                     /transl_table=11
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDTYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            complement(7134..7754)
                     /locus_tag="AK725_RS04375"
                     /old_locus_tag="ERS020212_00856"
     CDS             complement(7134..7754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /locus_tag="AK725_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00856"
                     /product="hypothetical protein"
                     /protein_id="WP_000839915.1"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTVFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     misc_feature    complement(8024..8037)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    complement(8083..8100)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            complement(8137..9000)
                     /locus_tag="AK725_RS04380"
                     /old_locus_tag="ERS020212_00857"
     CDS             complement(8137..9000)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="AK725_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00857"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001093639.1"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEVKSNLSNFKHLSARLLDDRNYDDLEYLYKIEVERSTF
                     LTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     gene            9193..9363
                     /locus_tag="AK725_RS13195"
                     /old_locus_tag="ERS020212_00858"
     CDS             9193..9363
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /locus_tag="AK725_RS13195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00858"
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_001227862.1"
                     /transl_table=11
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQK
                     KSNGLDVGKAD"
     misc_feature    complement(9195..9210)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            9466..9690
                     /gene="pneA1"
                     /locus_tag="AK725_RS04390"
                     /old_locus_tag="ERS020212_00859"
     CDS             9466..9690
                     /codon_start=1
                     /gene="pneA1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /locus_tag="AK725_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00859"
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="WP_000181087.1"
                     /transl_table=11
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIILK
                     SAAASSKVCISAAVSGIGGLVSYNNDCLG"
     CDS_motif       9466..9552
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /locus_tag="AK725_RS04390_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9553..9690
                     /prepeptide="core"
                     /locus_tag="AK725_RS04390_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="4315.8"
                     /monoisotopic_mass="4313.2"
                     /core_sequence="SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDC
                     LG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /leader_location="[9465:9552](+)"
                     /alternative_weights="4333.9"
                     /alternative_weights="4351.9"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
                     /alternative_weights="4424.0"
                     /alternative_weights="4442.0"
     gene            9697..9885
                     /gene="pneA2"
                     /locus_tag="AK725_RS04395"
                     /old_locus_tag="ERS020212_00860"
     CDS             9697..9885
                     /codon_start=1
                     /gene="pneA2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /locus_tag="AK725_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00860"
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="WP_000786759.1"
                     /transl_table=11
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFIA
                     SYLGSAQTRCGKDNKKK"
     CDS_motif       9697..9771
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNDFVIGKSLKELSLEEMQLVYGG"
                     /locus_tag="AK725_RS04395_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9772..9885
                     /prepeptide="core"
                     /locus_tag="AK725_RS04395_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="3743.2"
                     /monoisotopic_mass="3741.0"
                     /core_sequence="TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNDFVIGKSLKELSLEEMQLVYGG"
                     /leader_location="[9696:9771](+)"
                     /alternative_weights="3761.2"
                     /alternative_weights="3779.2"
                     /alternative_weights="3797.3"
                     /alternative_weights="3815.3"
                     /alternative_weights="3833.3"
                     /alternative_weights="3851.3"
                     /alternative_weights="3869.3"
     gene            10001..12991
                     /locus_tag="AK725_RS04400"
                     /old_locus_tag="ERS020212_00861"
     CDS             10001..12991
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /locus_tag="AK725_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00861"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_000875571.1"
                     /sec_met_domain="DUF4135 (E-value: 2.1e-91, bitscore:
                     299.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.2e-52, bitscore:
                     170.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSIIS
                     EKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKHPQ
                     RINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPWIVK
                     PLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESCLRFY
                     TYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKIVYKPK
                     NLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKKLPEYYYNF
                     GVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDTLFHRVTR
                     TLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKIDFEGGKNL
                     PVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTRVLFRDTNSY
                     ASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDIPIFYTDTNIN
                     EIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSFDQRKKGYKLNL
                     SNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGSKWCLEQTGNDMY
                     RGRAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGLTGDIGYFIVLSII
                     EDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINTLVRYYRRGIEKERV
                     LRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKVTRLKKYKELILQLVP
                     REKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGSMAIINFYIDYMKEMDT
                     SMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIAYTFLRYIALNQNDKKIV
                     IPSLLEI"
     misc_feature    13191..13204
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.84"
                     /tool="antismash"
     gene            13341..14045
                     /locus_tag="AK725_RS04405"
                     /old_locus_tag="ERS020212_00862"
     CDS             13341..14045
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /locus_tag="AK725_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00862"
                     /product="flavodoxin family protein"
                     /protein_id="WP_001033170.1"
                     /transl_table=11
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNSE
                     LEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFIER
                     IGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKDIAE
                     AQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRLFEAN
                     SLEEWYYVENIK"
     gene            14026..14955
                     /locus_tag="AK725_RS04410"
                     /old_locus_tag="ERS020212_00863"
     CDS             14026..14955
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /locus_tag="AK725_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00863"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_000912954.1"
                     /transl_table=11
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISIT
                     LHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKNSD
                     RNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAIREI
                     VLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVKGEGS
                     AFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSKNNKYL
                     EKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            14952..17060
                     /locus_tag="AK725_RS04415"
                     /old_locus_tag="ERS020212_00864"
     CDS             14952..17060
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /locus_tag="AK725_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00864"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000701298.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.3e-38, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRSG
                     YSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYILDP
                     AKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFFVTA
                     LLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVASLKYI
                     MDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDLLMIVV
                     YAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITSEVISKN
                     SDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLTLIVGVNI
                     KTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNTKSELIPER
                     VSQDIKFDKKIELKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSGKSTLAKILL
                     GLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTFGHFVSDEELM
                     TNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKPSVVVLDEATSS
                     LDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEIGTHRELLELGGI
                     YKQLYSNN"
     gene            17084..18823
                     /locus_tag="AK725_RS04420"
                     /old_locus_tag="ERS020212_00865"
     CDS             17084..18823
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /locus_tag="AK725_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00865"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_050265498.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.5e-38, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIMKKKYWTLSILFFCLFNNSVTAQEIPKNLDGNITHTQTSESF
                     SESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVN
                     SESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESY
                     KLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQD
                     RLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIIN
                     LSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLK
                     LISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLS
                     ELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNY
                     MFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERI
                     QTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAK
                     KSK"
     gene            18874..19641
                     /locus_tag="AK725_RS04425"
                     /old_locus_tag="ERS020212_00866"
     CDS             18874..19641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /locus_tag="AK725_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00866"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_012677041.1"
                     /transl_table=11
                     /translation="MSQKLNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRMSSQDE
                     RQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQLTGPQSILFWIDAVQNY
                     VLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIATSIL
                     LFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEILVA
                     FLVSLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            19643..20275
                     /locus_tag="AK725_RS04430"
                     /old_locus_tag="ERS020212_00867"
     CDS             19643..20275
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /locus_tag="AK725_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00867"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000571429.1"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLESYDGMIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLAYLDLDKRIFELSGGESQRVALAKVILKNPPLILADEPTA
                     SIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     misc_feature    complement(20294..20307)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            20416..20694
                     /locus_tag="AK725_RS13305"
                     /old_locus_tag="ERS020212_00868"
     CDS             20416..20694
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843943.1"
                     /locus_tag="AK725_RS13305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00868"
                     /product="hypothetical protein"
                     /protein_id="WP_000712962.1"
                     /transl_table=11
                     /translation="MKKFDNYIIEKPCDSNSDKLQKILIIENLVDDILQFPLRINNSVG
                     EIFLLQPFQKKTIFIPCYFEEDIVKVKDDDKVEWNLLEFQKFRAFLA"
     gene            complement(21203..21616)
                     /gene="ndk"
                     /locus_tag="AK725_RS04440"
                     /old_locus_tag="ERS020212_00870"
     CDS             complement(21203..21616)
                     /EC_number="2.7.4.6"
                     /GO_function="GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ndk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /locus_tag="AK725_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS020212_00870"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_000438285.1"
                     /transl_table=11
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEEL
                     IDQHYQDLVGQSFYLPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRG
                     DFAKAAGENEVIQNVVHGSDSEESAKREIALWF"
     misc_feature    complement(21601..21614)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.04"
                     /tool="antismash"
     misc_feature    complement(21901..21912)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     misc_feature    complement(22716..22731)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    complement(22772..22784)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
ORIGIN
        1 tatggataag ggtcaacgtg gtctgagtgg ttgtttggtt ggttattcgt gcaatactcg
       61 tgcgttttaa ttccagctaa actccctgta tcaagcgttt tcggcaaacc tgcttcatct
      121 gctagattgc gtaagagttc gatataaagg cggtagtccg tcatgaactc ttctttggtt
      181 gaatggcttt caataagttc aaccgctgca taggtctcag cattccaacc gcccccaacg
      241 tcccaggcac cattatcaac aggtcctacc tgcatgatgc aaccgttccc aacaatgtgc
      301 gagaaaaaac ctaattctgg gtctttccgc cagtgataat ccgcttcatt ctgtacggtt
      361 gaatgcggat tcccagttga gtgtgcgtgt acttgcctat atggttgcac gccgacttga
      421 ggcaaatctg ttcttaattt actcacatta atttccatat tctactcctt atcaattaaa
      481 acaactcatt ttttacaatc cagaaccaga aactccttta tttctacctt acaaagaaga
      541 caatcttagt cacgattagg cttgtagata gaacttcaaa acgcactatt ttgacactgt
      601 aaataggact gacaaggtct gcattctatc tacaataaca ccccagacta aaaagctttt
      661 caaaagtata tttttacagt ctctatatgt ccttttcata aatactatac tttattatat
      721 catataaaag aagtcaaaag tctgttaaac tattttcaac accaaactaa agacgagaac
      781 acaagttttt tcgattttca ctagaggaaa tggattttat tcagtaaatc caactaggat
      841 tgcactttgg ttgccaagat tgccttgcct tcttttatca agggatgacg gaataatgag
      901 aagtacagtt gaactgtcat ggcaacccag ataagaggtt cacaaaggat aacaccctta
      961 tatcctgccc aaggaataat caaaaccaca aaaacgattt ttccgattag ttcaataaag
     1021 ctagaaacta gaggaaggat cttttgcccc aagccctgca agcaattgcg ataaatcaac
     1081 aagaggctca aaatgggata aaaggttgaa ctgatttgca gatagagact tccattttct
     1141 atcaagtaac catctgtcga actagccaag aaggaaacca aagctggact ggcaaaaaag
     1201 aggaaaatac aaacaaaaac tgcccaggat atacttaaac gactgccgat tcgaagacct
     1261 tgaacaatgc ggtcaggttg cttagctcct agattctgag aagcaaaggt cgtcattgat
     1321 gcagaaatag cggtcatagg aagaagggca aaggtcataa tgcgtcgagc tgccgtctgg
     1381 gcactaataa tcactgcacc aaatgtatta acagaagact gtaaaatcac actgccgata
     1441 gatacaattg aactcatcaa gcccatagcc aaaccttgct ccaagagatc tgcgtacaag
     1501 cttttgtccc atttgaaatg tttaaactgt ggcaagagtt ctggcacact tttacgaata
     1561 taataaaagc agagaaccgc tgataaacct tgcgaaataa tggtagcaag tcctgcggat
     1621 tgaactccca gatgcaattg cgtaataaaa tagagatcca gaaccacatt aaccaaggca
     1681 gagaaaatca gaaatcccag ggctgctaga ctgtcaccaa tagaccgcaa caagcctgca
     1741 aaaagattat aagcaaagct gacacctaca caggtcacaa tcatagaaat atattgataa
     1801 gattgaggaa gaatttctgc aggagtatct aagtattgca agagaggata caagccaaga
     1861 aagcccagca acataactag aatgctcaaa agagcaccta aaatccaagt agctgctact
     1921 gcttccttga ttttagtgaa attccgagcc ccataataac gagcaatgac aatccccatg
     1981 ccattgccaa caccaagtgt aaaacctaca atcaggtcaa aaatcgctgt cgtcgctcct
     2041 actgcagcca aggattcttg accaagaaat cgtccaacaa tcaagacatc agcagtgtta
     2101 tagagctgtt gaaaaatatt tgatagcaaa attggaaagg tgaagcttaa gagcgaggga
     2161 agaatcggac catgtatcag gtccactgtt cgttttttat tcataaagct attatatcag
     2221 ctttccagag gagcgacaag aaacagcaaa cttatatata gcggaatgaa ataaggaaag
     2281 tcaaatcgat ttttaacaat gttttagaag tagatatgta ctattctagt ttcgatctat
     2341 tatagttggt tgagtttgga atagtacgct gtagctgcta aaacatttct agaaattaat
     2401 ttgactttcc taatagagtt gttcatatct tatttcaagc tactatatat aatctaaaaa
     2461 cttgaatcaa aaatcgaaaa agtagcggat ttctccactg ctttaacagc ttattcttca
     2521 atttcgattt caagttcatc gcctaagtca agcgtaactt cttcattcac tgcttcttct
     2581 ttctttggct catctttttt gttttcagta tcttgttctg aaacttcttc tccatcaatc
     2641 aagccaaatt tagaacggac ttgcttatca atttcatcaa agatttctgg gtgctctgcc
     2701 aagtatttct tagcattctc agaaccttgc ccaatttttt catctttgta agaataccaa
     2761 gcccctgctt ttttgataat atccaaatcg cttgcaatct tcaaaagctc accagtctta
     2821 gaaattcctt ctccgtacat aatttcaact acggcttcct taaacggtgg agctacctta
     2881 ttttttacaa ccttaatctt agtttcttta ccgacattgg tttctttttg gtcaccagtt
     2941 cccttaattt gtgtattacc acgaacatcc aagcggactg aagcatagaa tttcaaagca
     3001 cgtccgcccg gtgttgtttc tggatttcca aacatcactc caactttttc acgcaattgg
     3061 ttgataaaaa tggcaattgt tttggtttta ttgatagagg cgccaagttt acgcatggcc
     3121 tggctcatca tacgagcctg caaaccaaca tggctatctc cgatatctcc atcaatttcc
     3181 gcacgaggaa caagggcagc aactgagtcg actacgacaa gatcaactgc acctgagtca
     3241 atcaattttc ccgcaatctc aagaccttgc tctcctgagt ctggttgaga caagagcaat
     3301 tcgtcaatat tgacaccaag ggccgcagca taagctggat caagggcatg ttccgcatcg
     3361 ataaaggcag caatcccacc ttctttttgc gcttgtgcaa ctgcatgaag ggcaaccgtt
     3421 gtcttaccag atgactctgg gccatagatt tcgatgatac gtcccttagg ataaccacct
     3481 gagccaaggg caatgtcaag agctaaagaa cctgagctca tcacttgcac cttttgctcc
     3541 gcacgttcac ccaaacgcat gattgatcct ttaccaaagt ctttctcaat caatttaaga
     3601 gcatcattca aggccttttc acgttctgcc ccaaattttt ttgaaatttc ttctaatttt
     3661 tttggttttt tcgccattct attctcctac attctaatga tcctcagacc tatctactat
     3721 tatatcaaaa gttagtcact taataaagcc ttgcgaacta ggttaaaggc atgcataacc
     3781 gcaatatgac gtacatctgc tcggcttctg cctccaatat taaccttgat aacctcagtt
     3841 ccttgctctt gcgccaagcc tatgaagact gtcccaactg ggtgtccttc taggctatct
     3901 ggtcctgcca ctccggtcaa actaattcca aaatcagact gggtcttgct tcgtgcctgc
     3961 tcagccatct tctgagctgt aaattcagac accacaccat gttcttccaa attcttggca
     4021 ggaatatcca acatccttga tttttcctcc aagctatagg tcacaaaacc acccttaaat
     4081 atacttgaag ctccagaaaa attcgccacg gtagcttgga aaagacctgc cgttaaactc
     4141 tctgcagccg cgatggtttt cccttgcctt ttcagttctt ctaccacaat gctggctaaa
     4201 ctagtttctt ccccataacc atagcaaaag tctcgtaaag aaattccttc gaaagtctgg
     4261 cagtccaaga tttgattttc caagatatcc agcgcttgat tcgcctcttc ttgactgcta
     4321 gcctttgttg acagacgtag agtgacttct cctgtcttgg cataaggggc caaggtagga
     4381 tcgatctgat tatcaattaa atcagccaaa atcgtaacca gctggctctc gccaatccca
     4441 aagaaacgaa gaactcggga atacagcttg ctccctgtca tcaacttggg tagaagttgg
     4501 tttaagacca tgggtttcaa ttcacttggc ggacctggaa ggacgacata ggtcactccg
     4561 tctacttcta attttcctcc aacagccagt cctgtttcgt ttggcagtgg aatcgctcct
     4621 tctacaattt gagcttgtct ttcgttattc ggtgttcggg catagtctgg tcgcagggca
     4681 aaaaagatat ccaacttctc ctgagcctga ggatcaaaga ctaatgcttt ccctaaaaat
     4741 ttagctaggg tttgtttggt taggtcgtcc tcagttggcc ccaaaccgcc tgtcaaaatc
     4801 accagactgc tacgttgact ggcaatctca agcaaagaca agagacgaac ttcattgtct
     4861 cctacagccg tctgaaaata tacatctacc ccaatctcag ctagtttttc cgacaaaaac
     4921 tgggcattgg tgttgacaat ctgtcctgtc aaaatctctg ttccaacagc aatgatttct
     4981 gctttcatgt ttcctcctac ctatctattc gtattttttt gaaaaaatcg caggaatttt
     5041 cctacgattg atttttttat ttgtatcaaa agttaattat cttcatcacc aacaggtgct
     5101 ctgccaaata aatcttcaaa taaaaccgca ttggtttcaa gctgagtaac ttcttcttgt
     5161 cccaaagaac gtcggagtat attttgcatt tccaacatat gtgctctcga aacaatctgg
     5221 taagaaacac cttgaagtat ctctccttca ccctgcaact gctgagtttc aatggtttta
     5281 aatgaatctt tatagcctag caagttaggg atactttttg cagacaaatc aatattggtc
     5341 tgcatattgt cactcaaagc ttttagaatc tcttgataat gaccaacgct atttaaactg
     5401 agagcttttt ccatgacttt ttgaataact tcacgttgac gtttttgacg accataatcc
     5461 ccctcaggat cttggtaacg cattcgtgca tagactaggg cttcttctcc cccaatatgt
     5521 tgctccccaa caccgataga aatggtatta aattcttctt ggtcactgat agaaattggg
     5581 aaacctagga tattattgac tgtaatacct cctactgcat ccactaattt ttgcaaccct
     5641 ctcatattga ccatcacata gcgatcaata tggatattca tcattttttg aatggtttct
     5701 atagcaagct ctgctccacc atctgcatat gctgagttca gtttcgcttc atgagcctga
     5761 ccattccctg attcaatgcg cgtcagaata tcccgctcta aactcatcat tgttgttttt
     5821 ttcgttttag gattcactgt catcaagatc atgctatcac ttctaccgac ccaagtttca
     5881 gttcgttcaa catttccggt gtccactccc attaacagaa tggttagagg ttcagtcgct
     5941 tcaataacct tggtttcttc gccgattttt ttataggttt tagctaaggt ttctgtccct
     6001 tgttgataaa tagtataagc aaaaacacct actcctacta cagttacaga aagtaaagct
     6061 agcaccattc caataatttt tttaaccata tttctactaa cctatcagtt tacccatcaa
     6121 gtaaacatcg ataaatttcc cttcttctat atatgcccca cgctcttggc taccttcaat
     6181 gacaaagcca tgcttttgat aaagatggac tgctgcttga ttacgagttt ggacagtcag
     6241 ttggagacga cgcagaatgc cacctgcttg tgcccactct atcgcttctt ctagcaacaa
     6301 acttcccaag ccattattcc aatatctttt tccaatcaca atgaagagat ccccaatatg
     6361 acggactctc ttacgctggt cagctgtaat atttacaata ccagcaattt tgccatttaa
     6421 gaatgcaagt aaggttatct gattgtccga actagcttgc ttgttgagga atatttccat
     6481 ctcctcacta gtcaagagaa taccatctcc gtctaggctg gtaaagtctg tctccaaact
     6541 cacacgattt aaaaaggcca ctaattcagc tgcatctttg ggctctgctt ccctaatgag
     6601 caattcatac tccatattga agctcctcta acaatttctc agcacgcaaa ccctttgcct
     6661 gaaaatttaa acggcgtcca tctgcttctt ttagaatttc caattctaaa taagtatctg
     6721 gcaaggcatc tcctaagaga tttccccact caataacagt cacaccgcca ccaaagataa
     6781 actcatccaa gtcgatagaa tcagcatctc cttcaatacg ataaacatct aggtgataaa
     6841 gtggaagtcg accttcatac tctctcacga tagtataggt gggactttta atcatttgag
     6901 aaatctgtaa tccttttgca agtcctttag taaaggtcgt tttacctgca cccagttctc
     6961 cagttaagat taaaacatca ttctttgcta atagatggcc caaacgctcc cctaaggctt
     7021 gcaactcttc ttcatttttt gtgtacatac tcttattata ccaaaaactt ttcttttgtg
     7081 tctattttcc tactaaactt atcatcataa catccataaa aaacaggctt tctctaaaag
     7141 aaaatgagcg taacaatgac caatacaaga tctcggaaaa tatgaccata aaaggaaact
     7201 tccttcttaa ccgaatttgg gacaagatag gctgcaaaaa acaagcccag tccaatataa
     7261 atcagaagtg agacaatggt cattggattt cttaagaaaa gaagtgttgc taaaatagtc
     7321 accaacactg tcttttttct gtctagcata gcaagaaaat cgcgcacgta ttttttcaag
     7381 ggtaaaaaaa tcagcaaatc tagcccaaat aggaaaaaga aggatggcaa taaaaagtca
     7441 actaattctt gctgcagcgt atttttgatg aacaagttat ctgacaaaac aagaacagct
     7501 cctaacaaat taattaagag taacatactg taaaaaagct tcacagactt cttactggct
     7561 aggacactat ggacttcttg cttacgggta taaagataat ttactccagc acagattcct
     7621 gaaacgaaaa ccatgcttcc gatgaaaaaa actgtacttt gtttaaagga caagatgcat
     7681 tccttccata ggaaacagct actcaaactg atttgaatta aagctaacaa aaataagatt
     7741 ctcattgatt tcatcttctc tctcccttcc taccaatcat tatactagga gaaaagagag
     7801 aactgtttct aatcttctca aatgtctctt taagacgcta aacaaacact agagactaat
     7861 actcaatgaa aatcaaagat caaactaggt agctagccac aggttgctca aaacactgtt
     7921 ttgagattgc agatagagct gacgtgattt gaagagattt tcgaagaata taaatttgaa
     7981 atcatgaaaa tccgtcaaac gggtggttgt tttgtctcgc acctcacgga gcgagacgga
     8041 ctcagagtca cataattata aggctgatag tattaatcta actatcagcc ttacaggtta
     8101 tttaacgttt cagaaaaact ataatgtcaa gattaactaa acagtatcta attccttcaa
     8161 ataattttct atcttcatca acattaaagg attgttataa atcttacata actctcttgc
     8221 ttctatataa taatttttga cttgttctct gtctagaaat ttggctccag catttcctac
     8281 aagaataagt agaggagcca attggtagct tgtctgtctt tgtttacaga gttcaatcgt
     8341 ttcaagagct tcttggatgg cttcattata tttttccttt gatactaggt agtgagcgta
     8401 gttgtaacga actctgatgt agccaaataa aaactcttga tggtccaaat tttttgtctg
     8461 atacaactct attaaatgag agtagtttgc ctcatattct tgttcacgac ccactaagga
     8521 atagaaatta gatagagtat tcaacgcctt taaataaatc agagtatttg aagagacttt
     8581 taataatata ttttccaatg aagaaattgc ctcacactta ctgtcatatt gatagaagtc
     8641 aataatagct ttaatccatt caaggtaagt tcggtcttct aatgttagaa aagtgcttcg
     8701 ttctacctct attttataaa gatattctaa atcgtcataa tttctgtcat ctaataggcg
     8761 agcagataga tgtttgaaat tagagaggtt agacttaact tcgatttgtt cattgaaaaa
     8821 gtaatccaaa gggacttcaa gtcgttgaga gagtttgaat aacaagtctg cggagggaat
     8881 aaaatgacct ctttcaattt tactaatctg gctttgttca caaattcctt ctgcaagagt
     8941 ttgttgggag agtctcaact cttttctttt caatctgaat ttctctgcga gtgtattcat
     9001 taaagataat aaaccttcct atttgcttaa tttcattata aagtttttag ttcaaaatag
     9061 caagttaaag gaataaataa ttctttatgg taataaacaa aaaaaaaaag ttaaaaatta
     9121 cataaaaata cttgactaaa taaaatatat ctgttagaat aaaaacaagg aaaaagaaag
     9181 gggtttcatt gcatgagaaa aaaacgtgga attaaaaaat tagttacatt tgcattgcta
     9241 ggtgttttta tgtttagtaa tacaattcct taccaacagt ttattcagaa gaataaacaa
     9301 ttggagattc gagtgcaatc gcaaaagaag tccaatggtc ttgatgttgg gaaggcggat
     9361 taaaacccga tattttgcac gagaatgaga gaattataat ttatctgaaa aaacgaaaaa
     9421 tatagagcaa cttatttaac tttttataag gaggagttat tacttatgac caactttaat
     9481 tcaaacgaaa aattttgtgg aaaaagttta aaatcattgt ctgctgatga aatgagttta
     9541 atttatggtg catctgatgg tgcagagcca cgttggacgc ctactcctat tattttgaaa
     9601 tcagctgcag ctagctcgaa agtatgcatt agtgcagctg tttctggtat tggggggcta
     9661 gttagctaca ataatgattg tttggggtaa attaaaatga aaaatgattt tgtaatcgga
     9721 aagagtttga aagaattatc tcttgaagaa atgcaattgg tttatggtgg cacagatggt
     9781 gctgacccta gatcaacaat tatatgttct gctacattaa gttttattgc atcatatttg
     9841 gggtcagctc agactcgttg tggcaaagac aacaagaaaa aataaaatat tcaattttaa
     9901 aaataaaagt tgctctttat tttcctctct cgtaactaat aattttgaga gaggtttttt
     9961 tttaaaacaa tagtaagtcg tataggtttg aggtaagtaa atgaaatata aaattaaaaa
    10021 tgtgcataaa acattgttta ttaaggaaag atatcaaata ttatctgaac gaaatgataa
    10081 ttccttaaat aacttttcat taaataattg gcgttctaca atgtcaatta tttctgaaaa
    10141 aacttttgaa gaaatgttga aattaaataa ttacaataaa aaaatatttt ctaacactgt
    10201 gaactatgat tataccgagg aacagataag actatattca gaatatgcca aaaattcgga
    10261 atggtataaa tttgcggagg gttcatttga aatatttaga aaacatcccc aaagaattaa
    10321 ttttaagaaa gatttttcta gaattttgga accctttatt attaatttgc ttaaattaat
    10381 caataattat ctagagaata aagaatacga gtggattgac aagaatggaa atattttttc
    10441 ctctctagta ttttatttag aagatttaat ctatccttgg attgttaaac ctttggtttt
    10501 agagataaat tcattgcgtg aaaaaggttt acttgaaggg gaatcggagc agcaacggta
    10561 caaatatttt ataacattgt ttgacaagga agagaatata ttaaattttt ataacaaata
    10621 tcccgtttta ctgaggcaaa tatcggagtc ttgtcttcgg ttctatactt attttataga
    10681 aattttatca aatttagaaa atgattttag tgtgctagaa gaagaattag ggctaagggg
    10741 gaaattaaat gatataaaat ttggaaaggg tgatacacac agccaaggaa aaactgtttt
    10801 gatactcttc tttgatgacg cgaaaattgt ttacaagcct aaaaatttaa taatcaataa
    10861 ctcactaaat actattgctg agtatatccg aaaggttgat gaaaaaatta ggataagaat
    10921 acctcgaact attgcttatt cggatcacag ctatgaagaa tttattgatt atctacctct
    10981 agagcaaaag aaaaaattac ctgaatatta ttataatttt ggtgtgcttt tagcatttat
    11041 atatttattt aatgggagtg atatacattt tgaaaattta atttcctatg gagatatgcc
    11101 tgtaataata gactttgaaa caatgttaca gcaacctcta tttgatgata aaactggtca
    11161 gagtttgctg gataccctgt ttcacagggt gactcgaact ttgcttcttc caacagaggg
    11221 agtaaaaagg gaggatggtc ttgatgttga gatgagtgct cttacaggaa attttaagaa
    11281 ggatgctttt aatggtcaag ttttaattaa tttaaatact gataaggtaa agtttgatat
    11341 tgggaaaatt gattttgaag gtgggaaaaa cctgcctgtt cgggatggtg atatagaatt
    11401 tgataagtat ataaaagatt tcaaaaaagg ttttagggat ttttatctga tatttgaaga
    11461 gttaaataaa acagaagaat ttaaaatgct attaaaagca aacttgtatg gtttaaagac
    11521 aagggtactt tttagagaca caaatagcta tgcttcagta ctatcttttt tatatcatcc
    11581 tgatttttat gaagaaatgt tagatagaga aaaagcattg gaaaatctct ggagcaataa
    11641 gttttctaat caaggtattg tagcaagcga atgtgaacaa atgaggttat tagatattcc
    11701 gattttttat acagatacaa atatcaatga aatctacgat gattttggaa atcattttat
    11761 ttccctacat caattttctg gatatgacta ttttatgaaa tatttaccta ataataattt
    11821 ggaaaattta gaaaagcaac ttgatatcat tgaaatttat tttccaagct ttgatcagcg
    11881 aaaaaaagga tataaattaa acttatctaa tagaaaaaaa ctcccaaatg aaagtttagt
    11941 tactattctg cataatgaag tagaaaatat tgcagactct ttggttatta ataatattta
    12001 tgacgaatat ccaatttgga gtatacctgt taattttaaa ggttctaaat ggtgtcttga
    12061 acaaacgggt aatgatatgt ataggggtag agctggaata ttactgttta tgtactatgt
    12121 aaaattattg aaagataaat catcatatac tcaactgtac aataaaatgt tatctgcaat
    12181 tccgccatct gtttctttat ctaagaccac atttggttta actggggata taggatattt
    12241 cattgttcta tccattatag aggattacga tacaaatact ctcgcatgct taaattatat
    12301 aaagagtgtt ttaactgagc ttgaaaagac tgattttgca agtgtttcaa acaagtctga
    12361 ctatattaat ggtcttctac ctttaattaa tacactggta agatattata ggagaggaat
    12421 agagaaggaa cgtgttctaa ggctagtatt aagtttaggt gatacgctat ataatgatgt
    12481 aagcgagaga gataatagta attttggata tagttttggc catggactat caggtgtaat
    12541 ttttacatta aaaaatattt ataaagtgac aagacttaaa aaatataaag aattaatttt
    12601 acaactagtt cctagggaga aaatcaaaat tcattctttg aagtggtgta gtggagaatt
    12661 tgggacatta gttaatcatc cccaaagtgt tccagaggga attgtagcta gtttagataa
    12721 tgatacattt tgccatggaa gtatggccat aataaatttt tacatcgact acatgaaaga
    12781 aatggatact agtatggaat tggagtcttt attgtgtagt gttgtaatga ataaatcaaa
    12841 agaaggagag tatcgtatcg tccaaacaag caatttccca gatttttctt tgtatacagg
    12901 tgtgactggt attgcttata cttttttaag gtatatcgca ctgaatcaga atgacaaaaa
    12961 gatagttatc ccctcattac ttgaaatcta gcttaattta tagttttgtt tctaaaatag
    13021 aggtgtccac tcattaagca atataaaaat accaagattg actagtttaa tatgtaattc
    13081 tataaaatat ttttaatagt gtagcttttc gttgagataa taatataata aagaaaggtt
    13141 ctattctaat tgctaaacgg cttgaggtat atgctactgt tatagaaatg attttaaact
    13201 aaaatcaaaa ttactccaaa aatagtattg attttggttt aatacaaaac atatgtaata
    13261 atgtgagtca acaaaagtct gtttttgtac catactatct tgaaaaatct actaaattca
    13321 aattgagagg atgaattaaa atgaataaaa tatttatata tgcaggagtt cgaaatcata
    13381 actctaagac tttagagtat actaagagac tttcaagtat catttctagt agaaataatg
    13441 ttgatatatc tttcaggaca cctttcaatt cagagctaga aatatctaat tctgattcag
    13501 aagagttgtt taagaaagga attgataggc aaagtaatgc tgatgatgga ggtgttataa
    13561 aaaaagagtt attagagtct gatattataa ttatctcttc tcctgtatat ttacaaaacg
    13621 tatctgtgga cacaaaaaac tttattgaaa ggattggggg gtggagccat ctttttcgat
    13681 tagctggaaa gtttgttgta acattagatg ttgctgagag taacggctct gataatgtgt
    13741 cagaatatct tagagatata ttttcatata tgggaggaca gatattacac caagtttcaa
    13801 ttaccaattc actcaaagat attgcagagg ctcagttgat ggaggcaact tataaaattg
    13861 aagatgtact tgaagggaaa attaagtaca aaacaacgga ttatcaagaa agagcttacc
    13921 agacattaaa attaatttta gaaaattatg attccgaaca ttttgagaag atgtattggg
    13981 agaaaaaacg cctttttgaa gctaatagtt tagaggaatg gtattatgtt gaaaatatta
    14041 aataactctg tcatatattt atgtttgatt ccgttattgt tcctattatt gataattttt
    14101 ccaaatgatt cattaatcta ttattttcga ttgattttaa tttcgttaat atcaattaca
    14161 ttacatgaac taggtcattt tttagtggga agatgtttat cttataaact agagatgctt
    14221 gctactccct ttttcttcta tttcagaaaa aaaatatatt tcaaatttcc agtgttatta
    14281 gcattcggtt attgtcaaat gagtaataga aacattacta atgaaaaaaa tagtgatagg
    14341 aatttggtgt tctacttctt tgggggaggt ggagctaacc taattgtcgc aatattagca
    14401 cttttgggat ttgtgccgta cgcatcagaa ttttttattt tgaatataat tctttttcta
    14461 gttacggtat gtttaccaat tgatggaaca gatggcaatg ctattagaga gatagttttg
    14521 tattcaaaag attcaaaaac atatcagaga ttctttgcga acagtctcta taataatcct
    14581 tatataacaa tcgacgattt tgcaaaatta acctctaaag aaaaatcttt tttttcaaaa
    14641 tttgaaaaat gtttgataaa cctttacttt gaagtgaaag gtgaagggtc agcatttaca
    14701 attgctaatc atgaagtttt tgattcaaat attcaggaaa atattatcca tgagtactat
    14761 aaattactac ataaatcttc tgattggatt attccacaga acttatcttt agaagaagtt
    14821 gtttttacct tgtcaaacta tatttactcg aaaaataata aatatttaga aaagattaag
    14881 tatctaaaga aattagtaga ttttagacaa gaagaaatta tcgactttat tttgaacaag
    14941 gaggaagtat tgtgaaaatt ccaatgatat atcaaatgga aaattcagaa tgtggattag
    15001 catgctgtgc catgatattg aactatttta aatatgagat ttctttaaat gaactacgtg
    15061 aaatctaccc atcatccaga tctggatatt ctctcctatc tataagtaaa gttttaggag
    15121 attttaatat aagttctcat gcttttaaag cttcggtaag agatttaaaa ccgctcagtt
    15181 tcccactcat ttgcttctgg gagagttctc attttattat tcttgaaaaa attagtaaaa
    15241 acaagtttta tattttagat cctgcaaaag gcaggcagag aatgtcaata agtgaatttg
    15301 aaaggcatta ttcaaatatc attttaacat ttaaaaagtt agatagcttt atgtctcgta
    15361 aagataataa gaagtcgcct gttttaaagt atttttttaa gtataggaat aagctaggga
    15421 ttttattttt tgtaacagca ttattgtatg taatacaatc attagtacct atagctaata
    15481 gatacataat tgacacgaat ttcaaggacg attcgtattc gtctagaatg ttatttacta
    15541 tattatttat atttactgtt tcattctcac taatgtattt attaagacag atatatgttg
    15601 catccttaaa atatataatg gataaagaga ttagctatga ttttatgaaa catttgatat
    15661 atttacctta cagtttttat gaaaaacgta ctttagggga tatacttttt agagctaact
    15721 ctattgttta tataagagaa atactatcaa ataattttat agcagctata cttgatttgt
    15781 taatgattgt ggtttatgct gtggttttat ttagcttttc taagtacatg gtaatctttt
    15841 taatatcact aagtctagct ctatctattg taatgtatcc aatcataaaa atctcaaaaa
    15901 atttaattga taaaaatata aaagaaaagg ttaatgttca aaatattact tccgaagtaa
    15961 tttctaaaaa tagtgatatt aagctaactg gagaagagga attttggatt aacaaatggg
    16021 ataattttaa tacaaaacag ctcatcatag gtcgaaaact tgatatacat ttatcaattg
    16081 ttagtagtat aacgaatgtt ttacaaatta ttctccctgt tttgaccctt attgtaggtg
    16141 taaatataaa aacattcgaa caattgacgt taggacaaat tgtagcaata agtacagtct
    16201 caccatactt tatttctcct ataatttctt taagtgataa ctatatacaa ttaatgttat
    16261 taaagggata ttttttaaga atagaggatg tgtttaatac taaatccgaa ttaattccag
    16321 aaagagtcag tcaagatata aaatttgata aaaaaataga attaaaagat atttggtata
    16381 aatatggatt atttgatgat tatgttttga aaggaataaa tgttactatt aaaaaaggag
    16441 aaactgttgc tattgttgga gaatcaggtt caggtaagag tacattagct aaaattttat
    16501 taggtttatt agaacctaat attggttcaa tagaagttga tggagtagaa aaagaagaaa
    16561 ttggtcaaac attgtataga aagatttttg gagcagtgtt acaaaattca accctaagtt
    16621 atggtacctt aagagagaat ttgacatttg gacactttgt ttcagatgaa gaattaatga
    16681 caaatctaaa ttcaattggt cttagcaatg tagttaaatc tttacctctt ggattagaga
    16741 caatcatcgc tgaagaaggt aataactttt ctggagggca gcagcaaatg atacttttag
    16801 ctcgttgtct tttgtcgaaa ccttcggtag ttgttttgga cgaagcaaca agtagtttag
    16861 ataatttatc tcaacaaatt acaacttctt acttaagtga aatcggtacc actaagattt
    16921 taattgccca tcgactagat actatcaagt ctgcagataa gatcttagta atgcataatg
    16981 gtgaaattgt agagattggg acccatagag aacttcttga actaggaggc atttataagc
    17041 aattgtattc aaataattag tttttgatta aaagggtaaa tttatgaaga ttatgaaaaa
    17101 aaaatattgg actttatcga tattattctt ttgtttgttc aataattctg ttactgctca
    17161 agaaatacct aaaaatcttg atggcaatat aactcacact cagactagcg aaagtttttc
    17221 tgaatctgat gaaaaacagg ttgactattc taataaaaat caagaagaag tagaccaaaa
    17281 taaatttcgt attcaaatcg ataagacaga attatttgta acaacagata aacatttaga
    17341 aaaaaactgt tgtaaattgg aacttgaacc acaaataaat aacgatattg ttaactctga
    17401 aagtaataat ttactaggcg aagataattt agataataaa attaaggaaa atgtttctca
    17461 tctagataat agaggaggaa atatagagca tgacaaagat aacttagaat cgtcgattgt
    17521 aagaaaatat gaatgggata tagataaagt tactggtgga ggcgaaagtt ataaattata
    17581 ttctaaaagt aattctaaag tttcaattgc tattttagat tcaggagtcg atttacaaaa
    17641 tactggatta ctgaaaaatc tttcaaatca ctcaaaaaac tatgtcccca ataaaggata
    17701 tttaggaaaa gaggagggag aggaaggaat aatatcagat attcaagata gattaggtca
    17761 tggtacggct gttgtagctc aaattgtagg ggatgacaat attaatggag taaatcctca
    17821 cgttaatatt aacgtctata gaatatttgg taagtcgtca gctagtccag attggattgt
    17881 aaaagcaatt tttgatgctg tagatgatgg caatgatatt atcaatctta gtactggaca
    17941 atatttaatg attgatggag aatatgagga cggaacaaat gattttgaaa catttttgaa
    18001 gtataaaaag gctattgatt acgcgaatca aaaaggagta attatagtag ctgcattagg
    18061 gaatgactcc ctaaatgtat caaatcagtc agatttattg aaacttatta gttcacgcaa
    18121 aaaagtaaga aaaccaggat tagtagttga tgttccaagt tatttctcat ctacaatttc
    18181 ggtcggaggc atagatcgct taggtaattt atcagatttt agcaataaag gggattctga
    18241 tgcaatatat gcgcctgcag gctcaacatt atctctttca gaattaggac ttaataactt
    18301 tattaatgca gaaaaatata aagaagattg gattttttcg gcaacactag gaggatatac
    18361 gtatctttat ggaaactcat ttgctgctcc taaagtttct ggtgcgattg caatgattat
    18421 tgataaatac aaattaaaag atcagcccta taattatatg tttgtaaaaa aaattctgga
    18481 agaaacatta ccagtaaaaa atggtataaa agtgttaaat ataccaaacg tattgagata
    18541 tgatttgaat atgttacaat tagaatataa aaatgaacaa agttgggata gtttcataga
    18601 taatgttaat ttaattgagt tggaagagag aattcaaact actattggaa ttaaacaaat
    18661 aaacacacac aatattatta ctattgcccg agaagggtac tctcaaaatt atttacctaa
    18721 cacttcagaa aatacatata attcattaca agtcagttta gttggagtat tactactttt
    18781 tataagtatg gtaaatattt tatgggctaa aaaaagtaaa tgaaaataaa atttggagcc
    18841 ctctgaaaaa gtaagtccta cagttcaact aaaatgagtc aaaagttgaa tcaccttgat
    18901 gtaggggagt ttgtcttatt gctgcctgaa cacctccgtt cagaggaaga acattataaa
    18961 tctgtttttg aagacgactt aaccagtcgc atgtctagtc aagatgaacg acagcaaatg
    19021 actgctacgg taggttattt agaatcaggt caggatcgtt ttgtgtataa tacgacccct
    19081 atttcttacc agcagttttt gaaagatcca atcatcattg ttataacacc ccaattaact
    19141 ggtccacagt ccattttgtt ttggatagac gcagtacaga actacgttct ctttaatcaa
    19201 ttgtctgatg cccaggagct tatccagaga caaggcattg aaaattgggt ctcagaaatg
    19261 caaacaggtt accacaacta catcacatta ttggataata tccagaggga acgttgggta
    19321 atgctagcag gagctgtgct tgggattgca acttcaatct tgttgtttaa cactatgaat
    19381 aggctctact ttgaagaatt tagacgtgcc atttttatca aacgcattgc aggtctcagg
    19441 ttcttagaaa tccatcgcac ttatctcttt gctcaactgg gtgtgttttt actgggattt
    19501 gttgcgagtg tatttcttca ggtagagata ctagttgctt tcttagtctc gttactcttt
    19561 actggtctat ctcttttaca gttacatgtc caaatgcaga aagaaaacaa gatgtccatg
    19621 cttgttttga agggaggtta atatgattga acttaaacag gtgagtaaat cttttggaga
    19681 acgagagtta ttttcgaatc tttcaatgac atttgaggct ggaaaagtct atgccttaat
    19741 tggttcaagt ggtagcggaa aaacaacctt gatgaacatg attgggaaat tagaatctta
    19801 tgatgggatg attttttacc gaggtaaaga cttggccaat tataaatcga gtgatttttt
    19861 ccgtcacgaa ttgggctacc tcttccagaa ctttggctta attgaaaacc aaagtattga
    19921 agaaaacctt aagctaggtc tcattggtca aaagttgagt cggtcggaac agcggttgag
    19981 gcagaagcag gctttagaac aggtcggcct ggcttatctt gacctagata agcgcatctt
    20041 tgagttatcg ggcggagaat cgcaacgggt tgccttggca aaagttatct taaagaatcc
    20101 accccttatt ctggcagatg agccaacagc ttcaatagac ccagcaacct ctcagttgat
    20161 tatggagatt ttgctatctc ttcgagatga taataggcta atcattatcg caacacataa
    20221 tccggcaatt tgggagatgg ctgatgaagt gttcacgatg gatcatctga aataaaaatc
    20281 cttgttttta attgcacgat gagttactga aatattatca tgaatcaata attggagtta
    20341 atttagaatt gtactttatt aatattgagg taactttttc ttgataaagg aggaaatagt
    20401 ggagaggaag ttagaatgaa aaaattcgac aattatatta ttgagaagcc ttgcgattct
    20461 aattcagata aactgcaaaa aatcttaata attgaaaatt tggtagatga tattttgcaa
    20521 tttcctctca gaatcaataa tagtgtagga gagattttcc tcctacaacc gtttcaaaag
    20581 aaaactatct ttattccatg ttattttgag gaagatattg tgaaagtcaa agatgatgat
    20641 aaagttgagt ggaatttgtt agaatttcaa aaatttagag catttttggc ttagtaatct
    20701 gtgttgaagg ctcaaaacct atggtaaaaa agtcgctttg aaaacgtatt gcctccaaag
    20761 atttagttaa ataatgattt aacacaaaaa gaaattattg aagttctgga aagatgttgt
    20821 ttcagtattg agaaaaggtg ggaaaaactt gcgattttca cagagaaagg aagaaaaagt
    20881 atagaaatat agtcaattga aacaagaaca ggacaaaaga accttttgtg ccatattttt
    20941 ctcctttcgc tttacaattg gcttgaacac ctttattgta tcgcgtttgg agtttttttg
    21001 gtataacctt cgacgcgcac ccgcatagcg ggtgtttttt tgtctcgcac ctaacggagc
    21061 gagacgaact aatagtcact taatcaaaaa acgcaccata tcaaaaacta aaaagtttga
    21121 tatcatgcgt catgtcttaa actaattgac tatactttct attcaaatga gcttttaacc
    21181 aattgattga gccaatccac tcttaaaacc aaagagcaat ttctcgctta gctgactctt
    21241 ctgaatctga accatgtaca acattttgga taacctcatt ttctccagca gcttttgcaa
    21301 agtcacctcg aatagtgcct ggtaaagctt cttctggacg agttgcaccc atcatggtcc
    21361 gccaagtttc gattactttg ggaccagaaa tgacacccac aagaactgga cctgaagtca
    21421 tgaattcacg aatcggtagg taaaaactct gaccaaccaa gtcctgatag tgctggtcaa
    21481 tcaactcttc tgaaacctgt gaacgaaact ccaatttttc gattgtaaat ccacgttgtt
    21541 cgatgcgctt taacacttca cccactagcc ctctttttac accatctggt ttgatgataa
    21601 agaatgtttg ttccataccc gtctcctttg tcagcttctt tcttttattt taccacattt
    21661 cgtggaaaaa tggagaaagt tttcagaaga gagaatgaga gaaccctcgg gttctctcat
    21721 tctctcttat tctactgttt cttccacagt ttcaacggca gtatccacaa ctacttctgt
    21781 tgtttcttca tttccttctt cctctactgg aggattaagg tattcttctt cgttgacagc
    21841 atgtggttca aggttacggt aacgggccat accagtacca gctgggatga tcttaccgat
    21901 gataacattt tctttaagtc caaggagatg gtctttctta ccacggatag ctgcgtcagt
    21961 aaggacacga gttgtttctt ggaaggaagc tgctgacaag aaactgtttg tttcaagtga
    22021 ggctttggta attcccataa ggactgggcg acctgtcgct ggaactccac ctgcgataag
    22081 gacatctttg ttggcatctg taaagtcatt gatatccatg agggtaccca tgagaagatc
    22141 tgtatcacct ggatccatga cacggacttt acggatcatt tgacgaacca ttacctcgat
    22201 gtgtttgtca ccgatttcta ccccttggct acggtaaact ttttgtactt caccgagaag
    22261 gtacgtttca actgacaaga catcacgaac tgcaaggaga cgttttggtt ggatagaacc
    22321 ttctgtcaga gcagcaccac gcgctacttg gcccccaact tcgacacgca tacgagctgt
    22381 aaatggaacg acatattcac cttcgccagt ttcaccctta acaaagactt tcttggtacg
    22441 agttgatgca tcttcttcga tagcagtaac ttgtccttta acctctgtga taaccgcttc
    22501 ccctttagga ttacgggctt caaagatttc ttggacacga ggaagaccct gagtgatatc
    22561 ggtatttgag gcaaccccac ctgtgtggaa ggtacgcatt gtaagctgtg taccaggttc
    22621 cccgatagat tgggcagcaa ttgtaccaac tgcttcacca acttcaaccg catcaccagt
    22681 cgccaagttg ataccgtaac agtgacggca gacaccgtga cgagtgttac atgtaaatac
    22741 agaacggata gtcacttctt ccacaccagc attgacaatt tcacgcgcct tgtcttctgt
    22801 aatcaattca tttggaccaa taatcactgc accagtttct ggatgtttaa cagttttctt
    22861 agtgtaacga ccgttgagac gctcttcgag agactcgatc atctcttttc cttctgcgat
    22921 agaacggatc aagagaccac ggtcagttcc acagtcgtcc tcacggatga taacgtcttg
    22981 ggcaacgtcg a
//
