LOCUS       NZ_CP012159            22785 bp    DNA     circular CON 02-MAY-2024
DEFINITION  Chondromyces crocatus strain Cm c5 chromosome, complete genome.
ACCESSION   NZ_CP012159
VERSION     NZ_CP012159.1
KEYWORDS    RefSeq.
SOURCE      Chondromyces crocatus
  ORGANISM  Chondromyces crocatus
            Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
            Chondromyces.
REFERENCE   1  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals
            a high potential for natural compound synthesis and the genetic
            basis for the loss of fruiting body formation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-2015) Department of Microbial Natural Products
            (MINS), Helmholtz Institute for Pharmaceutical Research Saarland
            (HIPS), Campus E 8.1, Saarbruecken, Saarland 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Newbler v. 2.6, HGAP SMRTPortal v. 2.2.0
            Assembly Name                     :: Cm_c5_Newbler_HGAP3_v13
            Genome Coverage                   :: 366x
            Sequencing Technology             :: Illumina, PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001189295.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 07:18:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,172
            Genes (coding)                    :: 8,124
            CDSs (with protein)               :: 8,124
            Genes (RNA)                       :: 108
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 4 of 48
            Pseudo Genes (incomplete)         :: 44 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 2 of 48
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10380914
            Orig. end                         :: 10403699
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012159.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22785
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="36"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..22785
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22785
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12785](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12785)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            497..814
                     /locus_tag="CMC5_RS37595"
                     /old_locus_tag="CMC5_076750"
     CDS             497..814
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS37595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_076750"
                     /product="hypothetical protein"
                     /protein_id="WP_050434906.1"
                     /transl_table=11
                     /translation="MKALFLFLGLSAPLLVTAACGRGGEGPASHDKTGAPPCDAYVARL
                     EACSASAPAELREAHAAAIREARDRFEQKVELAETDPERLPLEETCKQLTDSLSERAGC
                     P"
     gene            842..1147
                     /locus_tag="CMC5_RS37600"
                     /old_locus_tag="CMC5_076760"
     CDS             842..1147
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020740371.1"
                     /locus_tag="CMC5_RS37600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076760"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_050434907.1"
                     /transl_table=11
                     /translation="MPTISFEASSLGPALSVDGEGALIDICDSENAPVGFSCRAAACAT
                     CQIEILAGAEHLESPGPDEKELLSMLGATETERLACQAVVRRGPGLIRIRWVGDGM"
     gene            complement(1182..1982)
                     /locus_tag="CMC5_RS45375"
                     /old_locus_tag="CMC5_076770"
     CDS             complement(1182..1982)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS45375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_076770"
                     /product="hypothetical protein"
                     /protein_id="WP_156339148.1"
                     /transl_table=11
                     /translation="MVTAPFEPPPSVSLHPSIGASGWSRWLEDPLRQVHREPLARWFAQ
                     RLFRIRIMPDRVVVVSALFAAASGVLVTTPALGRVVGAGVAFELSTILGRAGTLLADAH
                     RAHGTVSESQPANLQVKTAAIEWLGVLFLYGGLFYHVLVNPPPAGVWSTYASPAGVLLL
                     ALLLAIGRTAAASHYRLKYSALRGEGRDAQQAEGLRRLALALGPSSPRLDVVVLCLLLG
                     RVWMGQLLFVMVSLAWLLGVAILHGWLSKGDGRRAKLEDAQAVE"
     gene            2200..2574
                     /locus_tag="CMC5_RS37610"
                     /old_locus_tag="CMC5_076780"
     CDS             2200..2574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012239918.1"
                     /locus_tag="CMC5_RS37610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076780"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_245678094.1"
                     /transl_table=11
                     /translation="MRLIATAFVALPLALAACRSAQIGSVGAVLGRDGETQAVYIRDVP
                     SGLAADRAGLLPGDEILMIDGVYVRALTSKDLRARLRGDPGSTVELTVARGSDVRRLRV
                     IRSELREGRKAAPREERIDP"
     gene            complement(2588..2989)
                     /locus_tag="CMC5_RS37615"
                     /old_locus_tag="CMC5_076790"
     CDS             complement(2588..2989)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012239919.1"
                     /locus_tag="CMC5_RS37615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076790"
                     /product="YbjN domain-containing protein"
                     /protein_id="WP_245678096.1"
                     /transl_table=11
                     /translation="MRVEEIKACLEGEGWPVEALSSVTLRSGFEGSTRKFHLYVHVSPP
                     FVTFAVLPFGRLPAESDAADLVARRLLRLNREINMAKFSADEEGDILLSVEYRLEHLDP
                     SEVRDAVDVLSFYADRYYAEVQLLVSGRG"
     misc_feature    complement(3133..3148)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.97"
                     /tool="antismash"
     gene            3214..4329
                     /gene="dctP"
                     /locus_tag="CMC5_RS37620"
                     /old_locus_tag="CMC5_076800"
     CDS             3214..4329
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="dctP"
                     /inference="COORDINATES: protein motif:HMM:NF015445.4"
                     /locus_tag="CMC5_RS37620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076800"
                     /product="TRAP transporter substrate-binding protein DctP"
                     /protein_id="WP_156339149.1"
                     /transl_table=11
                     /translation="MKLAPLGLRALAVRSGASVYGNIRQLRAVMEVDMMMRRAAAVLLG
                     AFSLLVGLAHETRADEAKAGGADELKIGTLAPKMSPWGQVFTVWEKAVREKSGGKLELK
                     FFYNGQQGDEGAMIGKMKAGQLDGAAVTAVGLSKVNKDIVALQMPGLFTTWAKLDAARN
                     ALKGEFEEGVSKAGFRILGWGDVGLYRTMTKGFALRSPEDMRGKKPYMWRDDAIQPTFY
                     QTIGGVTPVPLNIPEVLPGLNTGTINVLVTPSLAAEQFQWASRLDHIGANVGGTAIGAV
                     ILTAKRMDALPGDLRTVVTDTGKVAAAALTQRIRNEDDAAYNRLKGKMTVVDLSADETA
                     KWSALFKQVRQRLAQGTFSGDLVNRLEGYAK"
     gene            4534..5856
                     /gene="metK"
                     /locus_tag="CMC5_RS37625"
                     /old_locus_tag="CMC5_076810"
     CDS             4534..5856
                     /EC_number="2.5.1.6"
                     /GO_function="GO:0004478 - methionine adenosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006556 - S-adenosylmethionine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="metK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020740379.1"
                     /locus_tag="CMC5_RS37625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076810"
                     /product="methionine adenosyltransferase"
                     /protein_id="WP_050436372.1"
                     /transl_table=11
                     /translation="MRRYQFTSESVTEGHPDKVCDQISDAILDGILAQDPTARVACETL
                     VKTGMAVVAGEITTSAWVDMPEVVRSTIKDIGYTDSSMGFDYATCAVLTAIEKQSPDIA
                     QGVTEGQGLHKEMGAGDQGLMFGFATDETPELMPSPITFSHRLAKRLAELRRNKKLDWL
                     RPDGKTQVTVEYEDHTPVRISAIVLSTQHAPEVKHKTIVEAVRSQIIDKVIPAKLIDKA
                     TKIYVNPTGRFVVGGPCGDAGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSACYYA
                     RYVAKNIVAAKLASRCEVQIAYAIGVAHPVGVHVSTFGTGRIDEELIEKYVMSNFDMRP
                     KAIIEQLDLLKPIYRKTAAYGHFGRDEFSWEKTDRAAKMADDLLRPTSTTVPAKVSSSA
                     KAPKISKDAKAPKNAKAPKETKAAKSIKAPKNPQPAKKKGK"
     gene            complement(5935..6951)
                     /locus_tag="CMC5_RS37630"
                     /old_locus_tag="CMC5_076820"
     CDS             complement(5935..6951)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020733698.1"
                     /locus_tag="CMC5_RS37630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076820"
                     /product="hypothetical protein"
                     /protein_id="WP_245678098.1"
                     /transl_table=11
                     /translation="MRCLPTAYRSLREAMMLAPTLLDAARQEGRPWMAGSLVEGPAILL
                     GAAQRAGRVVKLAACAEAGISVFRRATTGTAVHLGGRGVVWTLALPDVAALAHDATART
                     VLNRNVRFFLKGFGRAGVQAHYFGREWISIRRRPAAVIAAETTVEGAVVLEVWSGLDAS
                     LALPGRCAAPEELVLDRWLGKQPAALAEVLPAGVTPEILVEEVLVGIAAAAQVTREPVE
                     LRTGELSGLVDGSSGFGLPSSPPVAVSLERVPIGWIEAETLPAGDSLASESATRETCPR
                     VWLGGDVITGTWVLDALARGATSGDGSSTPRLEPDAVILEGATLEVLGTLAQRARSR"
     gene            7197..8336
                     /locus_tag="CMC5_RS47115"
                     /old_locus_tag="CMC5_076830"
     CDS             7197..8336
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02232.1"
                     /locus_tag="CMC5_RS47115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076830"
                     /product="hypothetical protein"
                     /protein_id="WP_050434913.1"
                     /transl_table=11
                     /translation="MQTRILLPLTAALVAASLHAGCLQNKLPLPDGDGGGGEGAGTTTG
                     EGGDGTGGTAGAGQGGTDNSGGAGGGTGGSGGDTGTDTCPGDAFDISLGVPLTLGGTTT
                     GFVDDYTSYCGTGTGSGPDTVYQFTPTSAGTMTVELTSFGDLNGVLYAQDVCGGPSFYC
                     SDRGTGIETLSFDAQVGEPYYIVVDGRDQTEGAYTLSARLDPAVCGDGVINAPQEECDF
                     GDTNPGDGCDATCQFEIPTDDSDTCPGQLHQASISSPLVINSFTTGYTDDYTSCGALPG
                     SPDRVFAVFASSSGTMTVTLPNLGAAGGGFDGVLAAWGGSCDAGNANAPSYLGCSDGMV
                     ASDEETLSFAVTAGSVYFIVVDGYASYSFGNFTLTVTIT"
     gene            complement(8365..9210)
                     /locus_tag="CMC5_RS37640"
                     /old_locus_tag="CMC5_076840"
     CDS             complement(8365..9210)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="CMC5_RS37640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076840"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_218920161.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 4.4e-17, bitscore:
                     61.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTRLREAAGVVLQALAEARIAAAPIKGVVTSVALYDDPLERPFG
                     DVDVLVGRHDLAGVRAVAREQGWRLVHDSRQLFAVNVVVPPGLPVDVRASLGPPALCRV
                     SAEEILARAEEVRDPRVVRAPFRMLTGHDHLLVLLLDAVLDKLALGAALRRRELELALR
                     RWVGSPEGFAEHLRAAGFAGIAWVVLRWLEGEGREPMVEAIRMALEPLPPVPRWLAAPT
                     LEAFGRAPYGPMARVGVRMIADVPWRGVAALVLGAVGTVRYHVRHRGRDPWEGVLWKGE
                     "
     gene            complement(9245..9697)
                     /locus_tag="CMC5_RS37645"
                     /old_locus_tag="CMC5_076850"
     CDS             complement(9245..9697)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS37645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_076850"
                     /product="S24/S26 family peptidase"
                     /protein_id="WP_050434915.1"
                     /transl_table=11
                     /translation="MGVLLALWEELRQRSGPFHVEMRGASMWPAAPEGSLLAVTPCSVG
                     ALSPGELVMFRRGAAVITHRVIRVTACGQVICWGDALLEPDTAVRAEDVLGRVTVVKRG
                     ALMVPARSVVRASMRTGWIAVRRMSATAVRVARGVHVRHGAGGHEG"
     gene            complement(9766..9969)
                     /locus_tag="CMC5_RS37650"
                     /old_locus_tag="CMC5_076860"
     CDS             complement(9766..9969)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS37650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_076860"
                     /product="hypothetical protein"
                     /protein_id="WP_050434916.1"
                     /transl_table=11
                     /translation="MKNGDVREGSSSAVSDGSSQEASSEGGQGESGLKRRRPYVAPARE
                     GGGGFTPITLGTRAPVLPGQGC"
     gene            complement(10001..11320)
                     /locus_tag="CMC5_RS37655"
                     /old_locus_tag="CMC5_076870"
     CDS             complement(10001..11320)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="CMC5_RS37655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076870"
                     /product="radical SAM protein"
                     /protein_id="WP_050434917.1"
                     /sec_met_domain="PF04055 (E-value: 1.7e-14, bitscore: 53.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.1e-06, bitscore: 27.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.9e-07, bitscore:
                     29.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTGFELNQKAAGGLPLMAQVLVSDVCNHACQHCYQVHGQKGEMS
                     LGEIEGVLDELKRLGVLIVSFSGGEASLRKDLPEILRAARQRAFAIILQSNGYALSDAL
                     LEVVAEVGVWRVRISVYSDVAAEHDAVTRVPGSFESTTGAIARLVARGVGVVMVVPLTR
                     LCSASVSRLEVLAGSLGCELEVESGITAKEDGSLTSLQVEPTREQLEAYLKVVAARGEA
                     TMDREAKLKATPCGACSSSITVHANGSVRPCTHIPVELADARRGESGAARIAAVAEEEA
                     FQFLARLRWEDLHGCRDCALMPWCSRCHGSAAFEAGDLLGPQPSACARALIRHQVEVGP
                     VELLSATEAEVAARGAGVGPFERVGALGVRPVRDVLSAADELLVSRFPWVRPSHERLVT
                     LAGIVPAQRLLRKTGRERRGPVEGAGTPEEEAPPLQRERT"
     misc_feature    11367..11384
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(11538..12785)
                     /locus_tag="CMC5_RS43620"
                     /old_locus_tag="CMC5_076880"
     CDS             complement(11538..12785)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="CMC5_RS43620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076880"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_169796780.1"
                     /sec_met_domain="PF05402 (E-value: 2.5e-15, bitscore: 55.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-10,
                     bitscore: 39.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSRAVALCADLPSLEFRLALRLEGLPLACREALEARWPEAMSGA
                     SHPAERSRIRLVLEASGEGVGLPSSALVTVELAWRSARRAVLRTNGAELELEVGDGEIQ
                     GQGWLDGARSRGAVDAVVRAVTTLALMREKVLLLHAAAVEVDGEGVVLLGRSGAGKTTT
                     ARRLGREGMRRLSDDMIAVDLSREPPRLHRLPFERAGRARVDASDQGVPCRGGAWVNKG
                     ATALGAERHGDPVRGWVESVIALPPAPSEAHSVLDAVGRLRALPLWVLEVPPAGALSSG
                     VRRWMDGLREGARIPLDGPLVSLQARAAGGTEGGAPESMGEQEQMQRVERSPNVAWRIL
                     DGVAVLVVPSSPAIQTLNEVGSLVWQLADGRSLDAIVDAVVREFEVEEAQARADVEHFV
                     SELEGLGMLRRVPETR"
     aSDomain        complement(11556..11732)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CMC5_RS43620_Stand_Alone_Lasso_RRE.1"
                     /evalue="5.20E-13"
                     /identifier="RREFam002.1"
                     /label="CMC5_RS43620"
                     /locus_tag="CMC5_RS43620"
                     /protein_end="410"
                     /protein_start="351"
                     /score="39.8"
                     /tool="antismash"
                     /translation="PAIQTLNEVGSLVWQLADGRSLDAIVDAVVREFEVEEAQARADVE
                     HFVSELEGLGMLRR"
     misc_feature    13061..13075
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            13061..14728
                     /locus_tag="CMC5_RS37665"
                     /old_locus_tag="CMC5_076890"
     CDS             13061..14728
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_function="GO:1904680 - peptide transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR01194.1"
                     /locus_tag="CMC5_RS37665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076890"
                     /product="cyclic peptide export ABC transporter"
                     /protein_id="WP_050434919.1"
                     /transl_table=11
                     /translation="MTIVDLISNEAGPDRRRLLLAATVAGASNALILALINKVAGSPQS
                     AGLGIFAMFGLAVLTYVIGVRHTYHRTTYFIETALHRIRTRLVAKVEKTGFQHLERIGN
                     AEIMDRLTENMAVVSESGGHVSHILQSLSILVFATLYIATKSPPAFALVVLIVAAGMSL
                     FISKKMEVNAFLQQSAQIRLKFFELLSDLLRGFKEVKFSQRRGRDLRQDITNASDNLRS
                     ATMKAEALFDDSVIFANCNLYAALASLVFVLPHHVNLEPKLLTMIVTAVMFSWSSVGGI
                     VIGYPLYLRSNQALENIRILEEKLDAAEQDESNTIDQAGPWSAPFNSIEARAIEYRYIT
                     DDASTPFHVGPIDLTITAGEVVFIVGGNGSGKSTFLKVLTGLYQPTRGTLKVDGIQVTP
                     ENVAWFRERISAIYSDFHLFSKLYGLLSIDEASVRRLLAQMQIEDKTTFTDQGFTNRHL
                     STGQRKRLALIITLLENRPIYIFDEWAADQDPEFRKYFYDELIPMLKLQGKTVIAVSHD
                     DRYFRCADRVITMEYGAIRSIETMTPGTSPTHDKTSAA"
     gene            14783..15397
                     /locus_tag="CMC5_RS37670"
                     /old_locus_tag="CMC5_076900"
     CDS             14783..15397
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016983.4"
                     /locus_tag="CMC5_RS37670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076900"
                     /product="DUF697 domain-containing protein"
                     /protein_id="WP_050434920.1"
                     /transl_table=11
                     /translation="MATETVTTTQTKQPGKHEIKEEIKTETKDGTKVEVKHEVKQETKT
                     EAPPADPFSRVGRAEAIIQRNVIWALGAGAIPVPVVDLAGVFAVQLKLLKQLSDLYGVK
                     FSNSIAKKITGSLLSSVGGVGIGTVIGAGLAKLVPTVGTALGVIAVPVFAGAFTHATGR
                     VFLMHFESGGTFLDFDPHTIRAHFRQEFEKAKETVGHTRAA"
     gene            15413..15658
                     /locus_tag="CMC5_RS37675"
                     /old_locus_tag="CMC5_076910"
     CDS             15413..15658
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010266016.1"
                     /locus_tag="CMC5_RS37675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076910"
                     /product="hypothetical protein"
                     /protein_id="WP_050434921.1"
                     /transl_table=11
                     /translation="MNLAPIFLYGLPILTVFAVGLLGSTRRIGFWLAVILSVVLTPIGG
                     FVVALLSGPKKYKPKYVTKKTGQGQLTASPGANAGG"
     gene            15766..16944
                     /locus_tag="CMC5_RS37680"
                     /old_locus_tag="CMC5_076920"
     CDS             15766..16944
                     /GO_component="GO:0005743 - mitochondrial inner membrane
                     [Evidence IEA]"
                     /GO_component="GO:0035632 - mitochondrial prohibitin
                     complex [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013324.4"
                     /locus_tag="CMC5_RS37680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076920"
                     /product="prohibitin family protein"
                     /protein_id="WP_050434922.1"
                     /transl_table=11
                     /translation="MAYRDPETDPTDPASEKDKKEEEPLTWRGRLSQWVNQAQFLVYTV
                     LVVALITLGFLWQRMFVTIQPGHHGVMYRFLAGGTVTDRIWGEGLQVIPPWDRLTIYET
                     RLQQQTLKFDVLSEEGLALGVIASVRYRPRQDMLGFLHQDIGADYFERVIKPEVQAHVR
                     RTFGSRPAHEIYSSARDVLQELGRVPEVGRVEDTDVGVTARSYVEIQELKLLDVKLPDV
                     VTAAIAEKYRQEQLMLEYRYKLEREEKEAERKRTEAAGIRDFNLIAAKVSPDLLRWRGV
                     DATLELAKSPNTKVVVLGAGQGNNPVLINLVDSPSGPPPANPAATDTASSAGGNEAYAA
                     RTATGATIQPPQTATPEVQTVAPGAPKAPSNASEQAKPSGPAASAAPAAPAP"
     gene            complement(17076..18659)
                     /locus_tag="CMC5_RS37685"
                     /old_locus_tag="CMC5_076930"
     CDS             complement(17076..18659)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS37685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_076930"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_156339150.1"
                     /transl_table=11
                     /translation="MSQAIHKDPPSPPRELFPTREIGALVAIVGVLVGMGYLLWRGGNA
                     KPAGPAPDRLVNVKLLTDIDRSVCGEPTRTGIPHVISMVYSDDKRRWIEDAAEQFSDLC
                     PNIQVKLDPREDLEAADVILLGEVKPTLWAPADELALRYIDHHWKHQSKDVLFRIEDQI
                     SLARSPLIALVWEDRMRVLDAIRDAQAKGGPRVPWHGPGPWAEMACALVPEEPEPFYVA
                     LEDRVPGRWIDWYEPLIPPPAPPVKPARGARKPPPPPPPVEVEYTPEFPTVNEIQRWGR
                     VKFGHTSPTRSTSGLEALYLMAYDYVMPPDRRPPLADETARGIGLTGADAERFIISGEH
                     LRLEFTQSLAERDEDLRNWLGRCEGGLENPLWSARLLTETMFNVGGGRFDGILTYEHLV
                     FSVLKRIDDHARVMRTMRVIYPQPTIVNQHPVVMLWPDDPALGVQREAAERWISFLRSR
                     PIQEKAIEYGFRPASPEVSIRAFDSYTNPFVHLRRYGISFQVPLEEPPRLDGPGIQGLI
                     GLWEDATGRN"
     gene            complement(18866..21979)
                     /locus_tag="CMC5_RS37690"
                     /old_locus_tag="CMC5_076940"
     CDS             complement(18866..21979)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="CMC5_RS37690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_076940"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_218920163.1"
                     /sec_met_domain="Pkinase (E-value: 9.4e-44, bitscore:
                     148.6, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 7.7e-06, bitscore: 24.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSLQARYEDIRLLGEGGVGVVYRAHDPRLGREVAVKLLKHGDP
                     ARHRRLLREARAQARVHHENVCPVYDAGEVDGEPYIVMQFVEGEPLWRLSPRLTLTQKV
                     EIMRAVSAAMHAAHRLGLVHRDLKPGNILVEPQAGGGLKPYIVDFGLAREVGGGAGKET
                     LGSDVAGTPAYMAPEQAAGGRIDVRTDVYSLGATLYELLSGRPPYVDDAPWKILARIAS
                     EEPAPLRSVGAEVPAALEAVTMTCLSREPARRYGSARALAEDLQRFLEGQRVGARRPLT
                     IARMWRRLRRRKELWAVSTLVLLAAVAVVAVLWVRSEADAAARLAQELGREAAGMELLM
                     RSAYQMPLHDVNRERALVRERLSGLERRLSDAGRAAQGPLHYAIGRGRLSVGDLEEAEA
                     HLEAARAAGYAPAELDYALGTTLLKLHGRRYLEVHRIADEAERTARLAEIDARYQAPAL
                     ALLGQASAGKLEPLAYGEALRAYYAGEFEEARVRAAEAFEQSPMLFEAKRLEGEALAGL
                     SLRDWTSGRPDAWGVMSARLEAAQAAFQTAEDVARSDPELLRAACLLGTRTMFAARFHG
                     EAPRPRFGRARVACEKAVIADPLNPLTLRARADLHALYAYALAGDPQPGEAPEREVRDA
                     VRFAEEALPANPNELEAYKTLGTALRAQMLLELNRGIAPRASVRRATEVYEAGIAKFPP
                     YGSAQESLATVLAMMVRVERWRGVSVEPTVERALALLDEGTARGASLSMSDAKRATLFL
                     EQGYWLLDKGRSPEEVMRRALEALRAGEARSPGWHGFARYAAEAHLIRAMDAQARGESP
                     QGALAEAVTALRLLEVSAPGMAVARDVEGMVALVEARQRVRDGRDPGEPLRRARGAFAA
                     GAAEVPWVLSFAVGLAQVELVAGAWAVSQGKTTDDGLAVIQAVKEKLSPWLVPDLADPE
                     PYVLLAEACALSLAQLPRRSSEGAEALLKEGFAFAEMALMRNPRLASALAVQGRLFLLQ
                     VGVAQAAANPIAAAEAKRQAYPALMSAVLQNPLLERELLSALAEASRE"
ORIGIN
        1 tcacctcccc cccctaccct ggcgtatacg actacgtcgc tcatcacgag gcccggctcc
       61 gctggctccg gctcccgcga gagcggttcg aagaagcgga gatcggcgcg cgccgccggc
      121 tagaacgcct cggcccagaa gaaggactct cccactggca caaggagatc ggtgcggtcc
      181 tcgcggcgat ggcacgcgtt cttcgaccgg acgggagtgc agtcctcctt ctggccgaca
      241 gcgtactcgc aggagagccc gtatacgcgc tcgacgcgat tcatgacgtg gcgactcccg
      301 cagggctcgt ggtccgagcg gccgcctccc aggagcgccc gcattttcat ggccctacca
      361 tgcgcgcctt ctcacgagcc ccccgggaag aacacgccat cctcttggct cattcgcctg
      421 ccgcttcccc ccagatccgc aggaaattgc ccccaggcag aggtcatgtg gcagggtctc
      481 gacgacccgg caaaccatga aggctctttt tcttttcctt gggctctcgg cgcctctcct
      541 cgtcacggcg gcctgtgggc gtggaggcga aggaccagcc agccacgaca agacgggcgc
      601 ccctccgtgt gacgcttacg tcgctcgcct cgaagcctgc tcggccagcg cgccggccga
      661 acttcgcgaa gcccatgccg ctgccattcg agaggcacgg gatcgcttcg agcagaaggt
      721 cgagctggcg gagacagatc ccgagcgcct ccccctcgag gagacctgca agcagctcac
      781 tgactcactc tccgagcggg cgggttgccc ctgatcccag ctgacgcgct aacctccgcc
      841 cgtgcctacc atctccttcg aagccagctc gctcggccct gcactctccg tcgatggtga
      901 gggtgcgttg atcgacattt gcgactcaga gaacgcgccg gtcggtttct cctgccgtgc
      961 cgcagcatgc gcgacttgcc agatcgaaat cctcgcaggt gcagagcacc tcgaatcacc
     1021 tggccccgac gagaaggagc tgctctcgat gctcggcgca acagagaccg agcgcctcgc
     1081 gtgtcaggcg gtcgtccgcc gtggcccagg gctcatccgc attcgctggg tcggcgacgg
     1141 catgtgacga gcatgccatt gccgcatgct cacgctcgcg ctcactcgac agcctgagcg
     1201 tcttccagct tcgcgcgccg accatccccc ttcgagagcc aaccgtgaag aatggccacg
     1261 ccgaggagcc aggccaaact gaccatcacg aagagcagct gccccatcca gacccgcccc
     1321 agcagcaaac agagcaccac aacgtcgagc cgcggcgacg atggaccgag cgcgagcgcc
     1381 aacctgcgca acccctcggc ctgctgggca tctcgcccct cgcctcgcag ggcactgtac
     1441 ttcaaccgat aatgactggc ggccgcggtg cggccaatgg ccagcagcag ggccaagaga
     1501 agaacaccag ctggagaggc atatgtgctc cagactcctg ccggaggagg attcaccagc
     1561 acgtgataaa agaggccgcc atacaggaac aaaacgccga gccattcgat tgctgctgtt
     1621 ttgacctgca gattcgccgg ctgtgactcc gagacggtcc catgtgcccg gtgtgcatca
     1681 gcgagcagcg tgccagcacg tcccaagatc gtgctgagtt cgaaagcgac tcccgccccc
     1741 accacgcggc caagcgcagg ggtcgttacc aggacgccag acgcagctgc gaaaagggca
     1801 gaaacgacca caacgcgatc gggcatgatc cgaatacgga acagcctctg cgcgaaccac
     1861 cgagcgagcg gctcacgatg tacttgccgc agcggatcct cgagccaccg actccagcca
     1921 ctggccccga tgctgggatg cagggacacg ctgggggggg gctcgaaggg ggcggtcacc
     1981 atgctcggct ccacgggcat gatgcgcccg gatcagggcg actctaggcc agcgctcttg
     2041 aaacaccaac tagaatgcgg gggccgacaa tcggcgagat tgtgcctccg catcgcgaat
     2101 gggacagcca gcacgccacg ctgcgtagtc atgtgcgcac tacgctgcgg actttccagc
     2161 gagcgcatcc atgaggcgat gcgcgctatc ctcgcgagcg tgaggctcat cgccacggct
     2221 ttcgtcgcgc tgcccctcgc gctcgcggcc tgtcgcagcg cgcagatcgg ctctgttggt
     2281 gccgtgctcg gtcgcgacgg agaaacgcaa gcggtctaca ttcgcgatgt gccttccggc
     2341 ctcgccgccg atcgcgccgg cctccttccg ggcgatgaga tcctcatgat cgatggcgtc
     2401 tacgtccgcg ctctcacctc gaaggatctc cgtgctcgtc tgcgaggcga tccaggcagc
     2461 accgtagagc tgaccgttgc tcgcgggagc gacgtgcggc ggcttcgcgt gatccgcagc
     2521 gagctgcgcg agggccggaa ggcggcgcct cgtgaagagc gcatcgaccc ctgatacccg
     2581 gaacgcatca cccgcgcccg gagacgagca gctgcacctc ggcgtagtat cggtctgcgt
     2641 agaacgagag cacatcgacg gcgtcgcgca cttcgctcgg gtcgagatgc tcgagccgat
     2701 actcgacgct gagcaggatg tccccctcct cgtccgccga gaatttcgcc atgttgatct
     2761 ctcggttcag ccggagcagc cgccgcgcca ccaagtccgc ggcatccgac tcggctggaa
     2821 gcctgccgaa cgggagcacg gcgaacgtga cgaaaggggg tgagacatgg acgtagagat
     2881 gaaattttct cgtcgatccc tcgaatccgc tccgtagcgt caccgaagac agcgcctcga
     2941 cgggccatcc ttccccttcc aggcacgctt tgatctcctc gaccctcatc gaggccattc
     3001 tatcccgacc gccgccctga cgcagaaccc actgctttgc cgcggcgcga catgaatcga
     3061 ctcacctcgg ccaccgtcca tcctttctgg cagcatcgca gaggaggatg tcggcgctgc
     3121 attccgacca gaaagaatga ttttcctact tgctccacga accgccttgc cacggcgcat
     3181 cacaacatcc tcgaagccca ttggtgaaga tgcgtgaagc tggctcctct ggggctacgg
     3241 gcgctggcag tgcgcagcgg ggcaagtgta tacgggaaca taagacagct cagagctgtg
     3301 atggaggtgg acatgatgat gcgtagagcg gccgccgtgc tgctgggagc gttctcgctc
     3361 ctcgtcggac tggcgcatga gacgcgtgca gacgaagcga aggccggagg cgctgacgag
     3421 ctgaagatcg gcacgctcgc gccgaaaatg agtccatggg gtcaggtctt cacggtctgg
     3481 gaaaaggccg tgcgggagaa gagcggtggc aagctcgagc tgaagttctt ctacaacggc
     3541 cagcaaggcg acgaaggcgc catgattggc aagatgaagg ctggccagct cgacggcgcc
     3601 gcggtcaccg ccgtgggcct cagcaaggtg aacaaggaca tcgttgccct gcagatgccc
     3661 ggtctgttca cgacctgggc caagctcgat gcggccagga acgctctgaa gggcgagttc
     3721 gaagagggcg tctcgaaggc tggctttcgc atcctcggct ggggagacgt cggcctctac
     3781 cgcacgatga cgaagggatt cgccctgcgc agccccgagg acatgcgcgg caagaagccc
     3841 tacatgtggc gcgacgatgc catccaaccg accttctatc aaaccatcgg cggcgtcacg
     3901 cccgtccccc tgaacatccc ggaggttctg cctggcctga atacaggcac catcaacgtg
     3961 ctcgtcacgc cgtcccttgc cgccgaacag ttccagtggg cgtcgcggct cgaccacatc
     4021 ggcgccaacg tgggagggac agccatcggc gccgtcatcc tcaccgcgaa gcgcatggac
     4081 gccctccccg gcgatctgcg cacggtggtg accgacaccg gcaaggtcgc cgcagctgcg
     4141 ctcacgcagc gcatccgcaa cgaggacgat gcggcctaca accggctgaa gggcaagatg
     4201 acggtcgtgg acctctcggc cgacgagacc gccaagtgga gcgccctgtt caagcaggtc
     4261 cgacagcggc tcgcgcaggg gaccttctcg ggcgacctgg tgaacaggct cgagggatac
     4321 gccaagtaac gcacacacag cctgtctcac ccggcctcga cgtcgatcca cgacgcgccg
     4381 gcagcaggac ggctcgacca tggacgccgg gatgcaccac catcccggcg tctggcgttt
     4441 gggcccccct cacgcgttga cggtgcctgg agggcgaact attcgttgac ctccatttct
     4501 gcgacccgta tctcctccgt caaggaagac atcatgcgcc gttaccagtt cacctccgag
     4561 tccgtcaccg aagggcaccc cgacaaggtg tgcgatcaga tctccgacgc catcctggac
     4621 ggcatcctcg ctcaggaccc gacggcccgc gtggcctgcg agacgctggt caagacgggc
     4681 atggctgtcg tcgctggcga gatcaccacc tctgcgtggg tggacatgcc cgaggtggtg
     4741 cgaagcacga tcaaggacat cggctacacg gactcttcca tggggttcga ttacgccacc
     4801 tgcgcagtcc tcacggccat cgagaagcag tcccccgaca tcgcgcaggg cgtgaccgag
     4861 gggcagggcc tgcacaagga gatgggcgct ggtgatcagg gcctcatgtt cggctttgca
     4921 acggacgaga cgccggagct catgccctcg ccgatcacct tctcccaccg gctggccaag
     4981 cgactcgcag agcttcgccg gaacaagaag ctcgactggc tccgccccga tggcaagacc
     5041 caggtcaccg tcgagtacga ggaccacacg ccggtccgga tcagcgccat cgtcctttcc
     5101 acccagcacg cccccgaggt gaagcacaag accatcgtcg aggccgtgcg gagccagatc
     5161 atcgacaagg tgatcccggc caagctgatc gacaaggcga ccaagatcta cgtcaacccg
     5221 accggacgct tcgtcgtcgg cggcccctgc ggcgatgccg gcctgacggg ccgtaagatc
     5281 atcgtcgaca cctacggcgg catgggtcgt cacggcggcg gtgccttcag cggcaaggac
     5341 ccgtccaagg tcgaccgctc ggcctgctac tacgcgcgtt acgtcgccaa gaacatcgtc
     5401 gcagcgaagc tcgcctcccg ttgcgaggtg cagatcgctt acgccatcgg cgtcgctcat
     5461 cctgtcggcg tgcacgtcag caccttcggg acgggtcgca tcgatgagga gctgatcgag
     5521 aagtacgtga tgtcgaactt cgacatgcgc cccaaggcca tcatcgagca gctcgacctg
     5581 ctcaagccca tctaccggaa gacggcagcc tacggtcact tcggccggga cgagttcagc
     5641 tgggagaaga ccgatcgagc ggccaagatg gcagacgatc tcctccggcc cacgtcgacc
     5701 accgtccccg cgaaggtctc gtccagcgcc aaggcgccga agatcagcaa ggacgccaag
     5761 gcccccaaga acgcaaaggc cccgaaggag accaaggccg ccaagagcat caaggcgccg
     5821 aagaaccctc agcccgccaa gaagaagggc aagtaagccc cgcgggcagg ccgcctgcct
     5881 gtcgacatgc tccgaagagc gctggtgccc atgcggcatc ggcgcatttc tcgttcaacg
     5941 ggaccgagcg cgttgcgcca gggttccgag cacttcgagg gtcgctccct ccaggatcac
     6001 ggcgtccggc tccagcctgg gcgtgctgct cccatcgccg ctcgttgcac cacgtgcgag
     6061 ggcatcgagg acccaggtcc ccgtgatcac atcacccccc agccacacgc gcggacatgt
     6121 ctctcgtgtc gcgctctcgg atgccaacga gtcgcccgcc ggcagggtct ccgcttcgat
     6181 ccagccgatc ggcacccgct cgagcgagac cgccacgggt ggcgaagatg gaagcccgaa
     6241 cccactgctt ccatccacca agcctgacag ctcccctgta cgcagctcga cgggctcgcg
     6301 cgtcacctgt gcggccgcag cgatccccac gagcacctcc tccacgagga tctccggcgt
     6361 aacccccgca gggagcacct ctgccagggc agcaggctgc tttccgagcc atcgatccag
     6421 caccagctcc tcgggcgcag cgcaccttcc cggcaaggca agcgaagcat cgaggccaga
     6481 ccacacttcc agcaccaccg cgccctccac cgtggtttcc gccgcgatga ccgcagcagg
     6541 ccgacgtcgg atcgagatcc actcgcgacc gaagtaatgc gcttgcactc cggctcgccc
     6601 gaaccccttc aaaaaaaagc gtacattccg gttcaatacc gtcctcgcgg ttgcatcatg
     6661 cgcgagcgcc gcgacgtccg gcagcgccag ggtccacacg accccccgac cgcccagatg
     6721 aactgccgtc cccgtcgtcg cacgtcgaaa cactgagatt cccgcctcgg cgcaagccgc
     6781 cagcttcacg acgcgcccag cgcgctgcgc agcgcccagc aagatcgcag gcccctcgac
     6841 cagactcccg gccatccatg gcctgccctc ctggcgcgcc gcatcgagca gcgtcggggc
     6901 cagcatcatc gcttcgcgca aagatcggta ggcggtgggc aagcaacgca cggcgtcctc
     6961 gaaagcgcag gaggcgccac catcagcgct tcggctccgg acgcttacca cacccgcatg
     7021 accgacgacg ccctcgcaaa tcaggctttt cgtgcccgga gtgacctctc ccctgacagg
     7081 atcgtgcgtc gcgagcgcct cgcgttggtt cgagcagcac cttcatgtaa aactttcgag
     7141 gctcgggcgt tcacgagcca cgctcactcg cgagcccaga cgcgcgcgga ggtgccatgc
     7201 agacccggat ccttcttccc ctgacggcag cgctcgtagc ggcatcactc cacgctggtt
     7261 gtctccagaa caagctcccc ctccccgacg gagacggagg cggcggagag ggcgcgggaa
     7321 cgaccacggg agagggcggt gatggcacag gaggcaccgc cggggcggga caaggaggga
     7381 cagacaacag cgggggagcc ggcgggggga caggcggctc cggaggcgac accgggaccg
     7441 acacctgtcc tggcgatgcg ttcgacatct cccttggcgt tccgctcacg ctcggtggaa
     7501 cgacgactgg tttcgtcgat gactacacct cgtactgtgg caccggcacg ggctccggtc
     7561 cggataccgt ctaccagttc acgcccacgt ccgccggcac catgaccgtc gagctgacga
     7621 gcttcggaga cctgaacggc gtgctctacg cccaggatgt ctgcggaggc cccagcttct
     7681 actgcagcga ccgcggtacg gggatcgaga ccctctcctt cgacgcgcag gtcggggagc
     7741 cctactacat cgtggtcgac ggacgcgatc agaccgaagg ggcctatacc ctctcggcac
     7801 gcctcgaccc cgccgtgtgt ggggacggcg tgatcaacgc cccgcaagaa gagtgcgact
     7861 ttggcgatac gaaccccgga gatggctgcg acgcgacctg tcaattcgag atccccaccg
     7921 atgactccga cacctgccca ggccagctcc atcaggcgag catcagcagc ccgctggtga
     7981 tcaactcctt caccaccggc tacaccgacg actacacctc gtgcggcgca ctgccaggct
     8041 ctccggaccg cgtcttcgcc gtcttcgcct cctccagcgg gaccatgacg gtcaccttgc
     8101 cgaacctcgg cgctgcaggc ggcggcttcg acggcgtgct cgccgcctgg ggcgggagct
     8161 gcgacgccgg caacgcgaac gctccctcct acctcgggtg ctccgacggc atggtcgcat
     8221 ccgacgagga gaccctctcg ttcgccgtca ccgccggctc ggtctacttc atcgtcgtcg
     8281 atggctacgc gagctacagc ttcggcaact tcaccctgac cgtcaccatc acctgacgct
     8341 cgcgcctcac tccgcttcgc ccgcctactc tcccttccag agcacgccct cccagggatc
     8401 tcgccctcgg tgccgcacgt ggtaacgcac cgtgccgacc gcgccgagca cgagcgcagc
     8461 cacccctctc cacgggacat ctgcgatcat gcggaccccc acccgcgcca tcggcccata
     8521 cggcgcccgc ccaaacgctt ccagcgtcgg cgccgccagc cacctgggca ctggcggcag
     8581 cggctcgagc gccatccgga tcgcctcgac catcggctca cgcccctccc cctccagcca
     8641 ccgcagcacc acccaggcga tccctgcgaa gcctgccgcc cgcagatgct cggcgaaccc
     8701 ctccggcgaa ccgacccagc gtcgcagcgc cagctcgagc tctctccgac gcagcgcggc
     8761 ccccagtgcc agcttgtcga gcaccgcatc gagcagcagc acgagcaggt gatcatgacc
     8821 cgtcagcatc cggaacggcg ccctcaccac ccgcggatcg cgcacctcct ccgcccgcgc
     8881 caggatttcc tcggcgctca cgcgacagag cgcggggggt ccgagcgaag cgcgcacatc
     8941 cacaggcaag ccaggcggaa cgaccacgtt caccgcgaag agctgtcgcg agtcatgcac
     9001 cagccgccac ccctgctccc gcgcgacggc ccgcacccca gccagatcgt ggcgccctac
     9061 cagcacgtcc acatccccga acggccgctc cagcgggtcg tcgtacagcg ccacgctggt
     9121 caccaccccc ttgatcggcg ccgcagcgat ccgcgcctcg gcgagcgcct gcagcacgac
     9181 ccccgccgcc tcgcgcaagc gcgtatccac caggagccgc gcccctagct ggacacgcgg
     9241 agcctcaccc ttcatgcccg cccgcgccat gccggacgtg aacgcccctg gccacgcgca
     9301 ccgccgtggc gctcatgcgt cgcacggcga tccagcctgt ccgcatcgat gcacgcacca
     9361 ccgaacgcgc gggcaccatc agcgcccctc gcttcaccac cgtcacccgg cccagcacgt
     9421 cctctgcgcg caccgccgtg tccggctcga gcagcgcgtc tccccagcag atcacctgac
     9481 cgcacgcagt cacccggatc acccggtgcg tgatcaccgc cgccccccgc ctgaacatca
     9541 ccagctcccc tggcgagagc gcaccgaccg agcagggcgt caccgcaagc agcgaccctt
     9601 ccggcgccgc cggccacatg ctcgccccgc gcatctccac atgaaacggc cccgatcgct
     9661 gtcgcagctc ctcccagagg gccaggagca cgcccatcga ccatcgaact tcgggaggat
     9721 gcccttcagc tcgccgctcc acgcagaccg ccgcgacgcg cccgactagc agccttgacc
     9781 tggcagcaca ggcgctcggg tcccgagcgt gatcggcgtg aagccccccc cgccctcacg
     9841 cgccggcgcg acatacggcc tgcggcgctt caacccgctc tccccctgcc ccccctcgct
     9901 cgacgcctct tgcgatgaac catcgctcac cgcggacgag ctcccctcgc gcacatcacc
     9961 attcttcatg gggccacctc tcccagggca gcttacccca ttacgttcgc tcacgctgga
    10021 gcggaggagc ctcctcctcg ggtgtccccg ccccctcgac cggccctcga cgctccctcc
    10081 cagttttccg gagcaagcgc tgcgcaggaa cgatcccggc gagcgtgacc agccgctcgt
    10141 ggctcggccg gacccaggga aacctcgaca ccagcagctc gtccgcggcc gagagcacat
    10201 cacgcaccgg ccggaccccc agcgcgccca cccgctcgaa cggcccgacc ccggcccccc
    10261 gcgcagccac ctccgcctcg gtcgcggaca gcagctccac aggccccacc tccacctggt
    10321 gccggatcag cgcccgcgcg cacgcagatg gctgaggacc gagcagatcc cccgcctcga
    10381 acgcagccga cccatgacag cggctgcacc atggcatcag cgcgcagtcg cgacagccgt
    10441 ggagatcctc ccaccgcagc ctcgccagaa actggaacgc ctcctcctcg gcgactgccg
    10501 cgatccttgc ggccccgctc tcccctcgcc gagcgtccgc aagctccacc gggatgtgcg
    10561 tgcacggccg caccgatccg ttcgcgtgga ccgtgatgct cgacgaacag gcaccacaag
    10621 gcgtcgcctt cagcttcgcc tcccgatcca tcgtcgcttc accacgcgca gccacgacct
    10681 tcaagtacgc ctcgagctgc tcccgcgtcg gctccacctg gagcgacgtc aggctcccgt
    10741 cttccttcgc agtgatccca ctctccacct ccagctcgca ccccagcgac ccagccagca
    10801 cctccagccg gctcaccgac gccgagcaga gccgcgtcaa gggcaccacc atcaccaccc
    10861 cgacaccacg cgcaacgagc cgcgcgatcg cccccgtggt gctctcgaac gatcccggca
    10921 cccgggtcac cgcgtcgtgc tccgccgcca cgtccgagta cacgctgatc cgcacccgcc
    10981 acacccccac ctccgccacc acctccagaa gcgcgtcgct cagcgcgtac ccgttgctct
    11041 gaaggatgat cgcgaacgcc cgctgacgtg ccgcgcgcaa gatctccggc agatccttcc
    11101 gcagcgacgc ctctcccccg ctgaacgaaa cgatcaacac ccccaggcgc ttcagttcat
    11161 cgaggacccc ctcgatctca ccgagcgaca tctctccctt ctgcccgtgc acctggtagc
    11221 agtgctgaca cgcatggtta cagacgtcgg aaacgagcac ctgagccatg aggggcagcc
    11281 cccccgcagc cttctggttc agctcgaaac cggtccccat gagcgctcac cccgagctgg
    11341 acgaccagct cgaaagccgc cgccgcgatc ccggtgctcg gatagacgcc ccctgcagca
    11401 tcaggcctcc agcgtaccgc agcgcccatg atgttggcac cgcgatctcc gctcctgccc
    11461 tcggcctccc ctcacgtgga tcgcagcgtt ggcgtggatc gcaccttcag ggtcgagatt
    11521 gcccgcacgg acgcggctca ccgcgtctct ggcacccgtc ggagcatccc cagcccctcc
    11581 agctcgctca cgaagtgctc cacgtccgcc cgcgcctgag cctcttccac ctcgaactca
    11641 cgcaccacag cgtccacgat ggcgtccagt gagcgcccat ccgcgagctg ccacaccagc
    11701 gaccccacct cgttgagcgt ctggatggcg ggcgacgaag gcaccaccag cacggcgacc
    11761 ccatccagga ttcgccacgc cacattgggc gaacgctcga cccgctgcat ctgctcctgc
    11821 tctcccatgc tctccggtgc gcctccttcg gtgccacctg ccgcgcgagc ttggaggctc
    11881 accagcggcc cgtccagcgg gatcctcgct ccctctcgca acccatccat ccaccgacgc
    11941 accccggacg agagtgcccc ggccggcggc acctccagca cccagagcgg cagcgcgcga
    12001 aggcgcccca ccgcgtcgag caccgagtgc gcttcggatg gagccggcgg aagcgcgatc
    12061 accgactcga cccacccccg cacagggtct ccatgccgct ccgcccccag cgccgtcgcc
    12121 cccttgttca cccatgcgcc accacgacac ggcaccccct ggtccgaagc atcgacccgc
    12181 gctcgtcccg cccgctcgaa gggcaaacgg tgaagccgcg gcggctctcg cgacaggtcc
    12241 accgcgatca tgtcgtccga gagcctgcgc atcccctctc gccccagccg ccgcgcggtc
    12301 gtcgtcttcc ctgccccaga cctccccagc aacaccacgc cctctccgtc cacctccacg
    12361 gcagccgcat gcagcaggag caccttctcc cgcatcaacg ccagcgtggt caccgcacga
    12421 accaccgcgt cgacagcccc cctcgaccgg gcaccatcca gccacccctg cccctgaatc
    12481 tctccatcac ccacctcgag ctccagctcg gcgccattcg tccgaaggac cgcgcgacga
    12541 gcgctgcgcc acgcaagctc gacggtcacc agcgccgacg acggcaaccc gaccccctct
    12601 ccggatgcct ccagcacgag acggatgcga ctcctctccg cggggtggct cgccccgctc
    12661 atggcctctg gccaccgcgc ctccagggcc tcacgacacg caaggggaag cccctccagc
    12721 cgaagcgcaa gcctgaattc aagggacggc agatccgcac acagcgccac ggccctggag
    12781 gtcatcgccc cctccatgct gcatccctca acggcgcagc gcctctttcc ccgcgtcgca
    12841 cgtcgtcttt acccctcgat gcggaagaat tccgctgccg ctcctgcgcg tactcggccc
    12901 cgtcctcatc gctcgatcga tcggtcgatc gactgatcca tccccccctc atcctcccgc
    12961 tcgatcgcat gaaggagcca ccgcgaatcc ccctgtggta acacgtgccc cggcgccggg
    13021 ctggaatgcc tccacaccgg ccctcgtccg aacgaccgcg atgacgatcg tcgatctgat
    13081 cagcaacgaa gccggcccgg atcgccgtcg cctcctcctg gcggccaccg tggcgggcgc
    13141 atccaacgcg ctgatcctgg ccctcatcaa caaggtcgcc ggctcaccgc agagcgcggg
    13201 cctcggcatc ttcgcgatgt tcgggctggc cgtcctcacg tacgtcatcg gcgttcgtca
    13261 cacctatcat cgcacgacct acttcatcga gacggcgctc caccgcatcc ggacccggct
    13321 cgtcgcgaag gtcgagaaga ccggctttca gcacctcgag cgcatcggca acgccgagat
    13381 catggatcgg ctcaccgaga acatggcggt cgtctccgag tcgggcggcc acgtctccca
    13441 tatcctccag tcgctctcca ttctcgtctt cgcgacgttg tacatcgcga ccaagtcccc
    13501 ccccgcgttc gcgctggtcg tcctcatcgt cgcagcaggc atgtccctgt tcatctccaa
    13561 gaagatggag gtgaacgcct tcctgcagca gagcgcccag atccggctca aattcttcga
    13621 gctgctctcg gacctcctcc gcggcttcaa ggaggtcaag ttcagccagc ggcggggacg
    13681 cgatctgagg caggacatca ccaacgcttc cgacaacctc cgctcggcca ccatgaaggc
    13741 cgaggccctc ttcgacgaca gcgtcatctt cgccaactgc aacctctacg cggcgctcgc
    13801 ttcgctggtg ttcgtcctcc cgcaccacgt gaacctcgaa cccaagctgc tgaccatgat
    13861 cgtgaccgcc gtcatgttct cgtggtcttc cgtgggcggc atcgtcatcg gttacccgct
    13921 ctacctgcgg tcgaatcagg cgctggaaaa catccgcatc ctcgaagaga agctcgacgc
    13981 tgcggagcaa gacgagagca acaccatcga ccaggcgggc ccctggagcg caccgttcaa
    14041 cagcatcgag gcccgcgcca tcgagtaccg ctacatcacc gacgacgcct ccacgccgtt
    14101 tcatgtcggc cccatcgacc tcaccatcac cgctggcgag gtcgtcttca tcgtcggcgg
    14161 aaacggcagc ggcaagtcga ccttcctcaa ggtgctcacc ggcctgtacc agccgacccg
    14221 gggcaccctg aaggtcgacg gcatccaggt cacgccggag aacgtcgcct ggttccggga
    14281 gaggatctcg gccatctact cggacttcca cctcttctcg aagctctacg gcttgctgtc
    14341 gatcgatgag gcgtccgttc ggcgcctgct cgcgcagatg cagatcgaag acaagacgac
    14401 cttcaccgac cagggcttca cgaaccgtca cctctcgacg ggacagcgca agcgcctcgc
    14461 cttgatcatc accctgctcg aaaaccgtcc catctacatt ttcgacgagt gggcggcgga
    14521 ccaggacccc gagttccgca aatatttcta cgatgaactc attccgatgc tcaaactgca
    14581 gggcaagacc gtgatcgccg tcagccacga cgaccgctat tttcgttgcg cagaccgcgt
    14641 gatcaccatg gaatacggcg ccattcgctc catcgagacg atgacgccgg gcacgagccc
    14701 cacgcacgac aagacttcgg ccgcctgaat ggggccgcat cgtcacttcg tttcagcaac
    14761 ctgaacccag gagtcacgaa ccatggccac cgagaccgtc accaccacgc agacgaagca
    14821 gcccgggaag cacgagatca aggaagagat caagaccgag accaaggacg gcaccaaggt
    14881 cgaggtcaag cacgaggtca agcaggagac caagaccgag gcaccgcccg ccgatccctt
    14941 ctcgcgcgtg ggtcgcgccg aggcgatcat ccagcggaac gtgatctggg ccctcggggc
    15001 gggcgccatc ccggtccccg tcgtggatct cgctggcgtg tttgccgtac agctcaagct
    15061 gctcaagcag ctctccgatc tctacggcgt caaattcagc aactccatcg ccaagaagat
    15121 caccggctcg ctcctctcca gcgtgggtgg cgtgggcatc gggaccgtca tcggcgcggg
    15181 cctcgccaag ctcgtaccga cggtgggcac ggcgctcggc gtcatcgcgg tgccggtctt
    15241 cgccggtgcg ttcacgcacg cgaccggccg cgtcttcctc atgcacttcg agtcgggcgg
    15301 cacgttcctc gacttcgacc cccataccat ccgcgcgcac ttccgccagg agttcgagaa
    15361 ggccaaggag accgtgggcc atacccgcgc cgcctgagag cactgacgtc ccatgaacct
    15421 ggcaccgatc ttcctctatg gcctccccat cctcacggtg ttcgccgtgg ggttgctcgg
    15481 gagtacacgg cggattggct tctggcttgc ggtcatcctc tcggtcgtgc tcacgcccat
    15541 cggaggcttc gtcgtggcgc tgctctccgg accgaagaag tacaagccca agtacgtcac
    15601 gaagaagacg ggccaggggc aattgacggc gtcaccggga gcgaacgccg gaggctgaac
    15661 aggcctccgg cttcgcctca cggcggccca cgaggtggct cacgcccctc gctccacgtc
    15721 cccggagctt cgagacagca ccgtcgctct cgctgaaaag acaccatggc ttaccgagat
    15781 ccagagaccg acccgacaga tcctgcgagc gagaaagaca agaaggaaga agagccgctc
    15841 acctggcgag gccgcctctc ccagtgggtc aaccaggcgc agttcctcgt ctacacggtc
    15901 ctggtcgtcg ccctcatcac gctcggcttc ctctggcagc gcatgttcgt gacgatccag
    15961 ccgggtcatc acggcgtcat gtaccggttc ctggcgggag gtacggtgac cgatcggatc
    16021 tggggagaag gcctgcaggt catccccccg tgggatcgac tgaccatcta cgagacccgc
    16081 ctccagcagc agacgctgaa gttcgacgtc ctcagcgagg aggggctcgc cctgggcgtc
    16141 atcgcgtcgg tccgctaccg cccacgccag gacatgctcg gcttcctgca ccaggacatc
    16201 ggcgccgact acttcgagcg cgtcatcaag cccgaggtcc aggcccacgt ccgccgcacc
    16261 ttcggcagcc gacccgcgca cgagatctac tcgagcgcac gcgacgtcct ccaggaactc
    16321 ggtcgcgtcc ccgaggtcgg gcgcgtcgaa gacacggacg tcggcgtcac ggcacgctct
    16381 tacgtggaga tccaggagct gaagctcctc gacgtcaagc tgcccgacgt cgtcaccgcc
    16441 gccatcgccg agaagtaccg ccaggagcaa ctcatgctcg agtaccgtta caagctcgaa
    16501 cgtgaggaga aggaagccga gcgcaagcgc accgaggctg ccggcatccg cgacttcaac
    16561 ctcatcgccg ccaaggtgtc acccgacctc ctccggtggc gcggcgtgga cgcgacgctc
    16621 gagctcgcaa agtcccccaa caccaaggtc gtggtcctcg gcgccgggca aggcaacaac
    16681 cccgtgctca tcaacctcgt cgacagcccg agcggcccgc cccccgcgaa ccccgccgcc
    16741 accgacacgg ccagcagcgc tggggggaac gaggcctacg ccgcccggac cgcgacgggc
    16801 gccaccatcc agccaccgca gaccgccaca ccggaggtgc agacggtggc cccaggtgcc
    16861 cccaaggcgc cttccaacgc ctccgagcaa gccaaaccct ccggtcctgc agcttctgcc
    16921 gcacccgcag cgcccgcccc ctgatcccct gacgcccaga cacggcgccc tgccgacgag
    16981 aacgcctcgg acctgatgcc catggcgcca gggagagggc gaagtccccg gcggcctgaa
    17041 ggctcccgcc gccatgagag ggacccgagc ggcgttcagt tccgaccggt tgcgtcttcc
    17101 cagagcccga tcagcccctg gatgcccgga ccatcgaggc gtggcggctc ctccagcggc
    17161 acctggaacg agatcccgta acgacgcaga tggacgaagg ggttcgtgta ggaatcgaac
    17221 gctcggatcg acacctccgg gctcgcaggg cggaagccat actcgatggc tttctcctgg
    17281 atcggccggc tccgcaggaa ggagatccac ctctcggccg cctcgcgctg cacaccgagc
    17341 gctggatcat cgggccacag catcaccacc gggtgctggt tcacgatcgt cggctgcggg
    17401 tagatgacac gcatcgtgcg catcacccgc gcgtgatcgt cgatgcgctt gagcacggaa
    17461 aagaccaggt gctcgtacgt caggatgccg tcgaaccgcc caccgccgac gttgaacatc
    17521 gtctcggtca ggaggcgggc cgaccagagc gggttctcta gccctccctc gcagcgcccc
    17581 aaccagttcc gcagatcctc gtcccgctcg gcgagcgact gcgtgaactc gagacgcaga
    17641 tgttcccccg agatgatgaa ccgctccgcg tccgctccgg tcaggccgat gccccgggcc
    17701 gtttcgtcgg ccagcggtgg ccgccgatcc ggcggcatca cgtagtcgta ggccatcagg
    17761 tagagcgcct cgagccccga cgtcgagcgc gtcggcgagg tgtgcccgaa cttcacgcgc
    17821 ccccagcgct ggatctcgtt caccgtcggg aactcgggcg tgtactccac ctccaccggc
    17881 ggcggcggcg gcggcggttt ccgcgcccct cgggcaggct tcaccggggg tgcaggaggc
    17941 ggaatcagcg gctcgtacca gtcgatccag cgccccggga cgcggtcttc gagcgccaca
    18001 tagaacggct ccggctcctc gggcaccagc gcgcaggcca tctccgccca gggccccgga
    18061 ccatgccagg gcacccgcgg ccctcccttc gcctgcgcgt cccggatcgc gtccagcaca
    18121 cgcatccggt cctcccagac cagcgcgatc aacggagagc gcgccaggga gatctggtcc
    18181 tcgatgcgga acagcacatc cttcgactgg tgcttccagt gatggtcgat gtaacgcagc
    18241 gcgagctcgt cggccggcgc ccacagcgtg ggcttcacct cgcccagcag gatgacgtcg
    18301 gcggcctcca ggtcctccct gggatcgagc ttcacctgga tgttcggaca cagatccgag
    18361 aactgctccg ccgcgtcttc gatccagcgc cgcttgtcgt cgctgtacac catgctgatg
    18421 acgtgcggga tcccggtcct cgtcggctcc ccacagacac tccgatcgat atcggtcagg
    18481 agcttcacgt tcacgagccg gtccggcgca gggcccgccg gtttcgcgtt tccccctcgc
    18541 cacaggaggt aacccatccc gacgaggaca ccgacgatcg cgacgagcgc gcctatttcc
    18601 cgcgtgggaa acagctccct cgggggagac ggcgggtcct tgtggatcgc ttgcgacacg
    18661 gccgcggatg atgccagcaa ccattccagt gagcaaacac ttcgtggcgc aaacggagcc
    18721 acccattcac gcaaccaccg tccacacgtt caatcgattc ctggagggta cacggcagac
    18781 gaccaatacg atcatcagcg ctccatcaac cgattgaatc aactatcacc agctcgatcg
    18841 ccacgactgt cccggcccat gcgcttcatt cacgagacgc ctcggcgagc gcgctcagaa
    18901 gctcccgctc gagcaacgga ttctgcagca cggccgacat gagcgccggg tatgcctgcc
    18961 gcttcgcctc ggccgcggcg atcgggttgg cggcggcctg cgccacgcct acctgcaaga
    19021 ggaacagcct cccctggacg gcgagtgcgc tcgccaggcg tgggtttcgc atcagggcca
    19081 tctcggcgaa cgcgaacccc tccttcaaca acgcctcggc gccctcgctc gaccgacgcg
    19141 ggagctgcgc cagcgagagc gcgcaggctt cggccagcaa cacatacggc tcgggatccg
    19201 cgaggtccgg gacgagccac ggcgagagtt tctccttcac cgcctggatc accgcgagcc
    19261 catcgtccgt cgtcttccct tgcgacaccg cccacgcccc cgcgaccagc tccacctgtg
    19321 ccagccccac agcgaaggac agcacccagg gcacctccgc ggcccccgcg gcgaacgcgc
    19381 ccctcgcccg ccggagcggc tctcccggat cccgcccatc gcgcacccgc tggcgcgcct
    19441 ccacgagcgc caccatcccc tcgacatcgc gcgccacggc catccccggc gccgagacct
    19501 ccagcaaccg cagcgccgtc acggcctccg cgagcgcccc ctgcggactc tcgccgcgcg
    19561 cctgcgcatc catcgcacgg atcaggtgcg cctcggctgc gtacctcgcg aacccatgcc
    19621 agcccgggct ccgcgcctcg cccgccctca gcgcctccaa cgcgcgacgc atcacctcct
    19681 ccggcgaccg ccccttgtcg agcaaccagt agccttgctc caggaacagc gtcgcccgct
    19741 tcgcgtcgct catcgaaagg ctcgccccgc gcgccgtccc ctcgtcgagc agggccagcg
    19801 cccgctccac cgtcggctcc acggacacac cccgccaccg ctcgacccgc accatcatcg
    19861 ccagcaccgt cgccagcgac tcctgcgccg aaccgtacgg cgggaacttc gcgatccccg
    19921 cctcgtacac ctccgtcgcc cgccgcacgc tcgctctcgg cgcgatccct cggttcagct
    19981 ccaggagcat ctgcgcccgc agcgccgtcc ccagcgtctt gtaggcctcc agctcgttcg
    20041 ggttcgccgg caaggcctcc tcggcgaacc gcacggcgtc gcgcacctcg cgctccggcg
    20101 cctccccggg ctgcggatcc cctgccagcg cgtaagcgta cagcgcgtgc agatccgccc
    20161 gcgcgcgcag cgtgagcggg ttcagaggat ccgcgatcac cgccttctcg cacgccaccc
    20221 gcgcccgccc gaacctcggt cgcggcgcct ccccgtggaa ccgcgccgca aacatcgtcc
    20281 gcgtccccag caaacaagct gcgcgaagca gctccggatc gctccgcgcc acgtcctctg
    20341 ccgtctggaa cgccgcctgt gccgcctcca gccgggccga catcacgccc catgcgtcgg
    20401 ggcgaccgct cgtccagtcg cgcagcgaca gcccggcgag cgcctctcct tccagccgct
    20461 tcgcctcgaa cagcatcggc gactgctcga acgcctccgc cgcccggacc cgcgcctcct
    20521 cgaactcgcc cgcgtagtac gcgcgcagcg cctccccgta cgccagcggc tccagcttcc
    20581 cggcggatgc ctggcccagc aacgcaagcg ctggcgcctg gtagcgcgcg tcgatctcgg
    20641 cgagccgtgc ggtccgctct gcctcgtccg cgatccgatg cacctccaga taacgccgac
    20701 cgtgcagctt gaggagcgtc gtccccagcg cgtagtccag ctccgcgggc gcatacccgg
    20761 cggcccttgc cgcctccagg tgcgcttcgg cctcctccag atcccccacc gagagccgcc
    20821 ccctgccgat cgcgtagtgc agcggcccct gcgcggcgcg ccccgcatcg gacagccgcc
    20881 tctccagccc cgacaggcgc tcccgcacca gcgcccgctc cctgttcacg tcgtgcaacg
    20941 gcatctggta cgcgctgcgc atcagcagct ccatccccgc cgcctcacga cccagctcct
    21001 gcgcgagccg cgccgccgcg tcggcctcgc tgcgcaccca cagcaccgcc accaccgcga
    21061 cggccgccag aagcaccagg gtgctcaccg cccacagctc cttgcggcgc cgcaaccgcc
    21121 gccacatccg cgcgatcgtc agaggccgcc gcgccccgac ccgctgcccc tccaggaacc
    21181 gctgcagatc ttcggccagc gcgcgcgccg agccgtaccg acgcgccggc tctcgcgaaa
    21241 ggcacgtcat cgtcaccgcc tccagagccg ccggcacctc tgcgccgacc gaccgaagcg
    21301 gcgctggctc ctcgctcgcg atcctcgcca ggatcttcca gggcgcgtcg tccacatagg
    21361 gggggcgacc cgagagcagc tcgtacagcg tcgcgccgag gctgtacaca tcggtccgca
    21421 cgtcgattcg cccgcccgcc gcttgctctg gtgccatgta ggcgggcgtc cccgccacat
    21481 cactcccgag cgtctctttc ccggcgcccc ctccgacttc ccgcgccagc ccgaaatcca
    21541 cgatgtacgg cttcaggcct ccgccggcct gcggctccac caggatgttc cctggcttca
    21601 gatcccggtg caccaacccc agccggtgcg ccgcgtgcat cgccgcgctc accgcccgca
    21661 tgatctccac cttctgcgtc agcgtcaggc gtggcgacag ccgccacagc ggctccccct
    21721 ccacgaactg catcacgatg tagggctcac catcgacctc ccccgcgtcg tacacggggc
    21781 atacattctc gtggtgaacg cgcgcttgcg cccgagcctc ccgcagcagc cgccggtggc
    21841 gcgccggatc cccgtgcttc agcagcttca ccgccacctc gcgcccgaga cgcggatcat
    21901 gggcccggta gaccaccccg acccccccct cccccaggag acggatgtcc tcgtaccgcg
    21961 cctgaagcga caggggcacc tgaggccgct gtggccgttc gacccagccg gatgccggca
    22021 tggtgtcatc gagcgcggcg tcttgcgtcg gagcgccagc ggctggttcg gggctgctca
    22081 gcccttcact tgaacgagcc cccatccgct gacgatagtc ccgctcttga cggaggtggt
    22141 tcacagaacg ccggacatcg agccctcacc aggaagcgcc gcgcctgccc ccggccagtc
    22201 ggtacaccga gggcggccgg tgcaccgtga caggaacgaa ggcgaccact tttccatctg
    22261 taacataact caaccgtcgc gcgagcgaag cccgaagcgg tccacccgcc gcaccatcat
    22321 gatccgcgtg atcccgagca gccgcgccgc ttccgcgacg tttccacgcg ctgccacgag
    22381 cgcctcctcc accagggaac gctccatcgg atccagcgcc gcgaaccgcg ccgcgagcga
    22441 catccccgtc gtcagcgacg acggcgacag cgcggccctc gacactgccg ggctgagatc
    22501 gtccagctcg atcaccgccc cttcggcctg aatcgccgcc cgctcgacct cgttcctgag
    22561 ctctcgcacg ttccccggcc acgggtaggc gtgcagcgca gccagcgccg ccggcgagaa
    22621 gcccagcaga cgcttgccca ggttgagcgc cgcgggctcc aggaacgccg cagccaggag
    22681 cggcaggtct tcacttcgtt cccggagcgg cggcaccgcg atgtccccca cgttcagacg
    22741 aaagaagaga tcctcccgga agcgcccctc ggcagcttcc ttccg
//
