LOCUS       NZ_CP012159            22501 bp    DNA     circular CON 02-MAY-2024
DEFINITION  Chondromyces crocatus strain Cm c5 chromosome, complete genome.
ACCESSION   NZ_CP012159
VERSION     NZ_CP012159.1
KEYWORDS    RefSeq.
SOURCE      Chondromyces crocatus
  ORGANISM  Chondromyces crocatus
            Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
            Chondromyces.
REFERENCE   1  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals
            a high potential for natural compound synthesis and the genetic
            basis for the loss of fruiting body formation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-2015) Department of Microbial Natural Products
            (MINS), Helmholtz Institute for Pharmaceutical Research Saarland
            (HIPS), Campus E 8.1, Saarbruecken, Saarland 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Newbler v. 2.6, HGAP SMRTPortal v. 2.2.0
            Assembly Name                     :: Cm_c5_Newbler_HGAP3_v13
            Genome Coverage                   :: 366x
            Sequencing Technology             :: Illumina, PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001189295.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 07:18:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,172
            Genes (coding)                    :: 8,124
            CDSs (with protein)               :: 8,124
            Genes (RNA)                       :: 108
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 4 of 48
            Pseudo Genes (incomplete)         :: 44 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 2 of 48
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5538091
            Orig. end                         :: 5560592
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012159.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22501
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="thioamitides"
                     /region_number="18"
                     /rules="((YcaO or TIGR03604) and TfuA)"
                     /tool="antismash"
     cand_cluster    1..22501
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and TfuA)"
                     /kind="single"
                     /product="thioamitides"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22501
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12501](+)"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and TfuA)"
                     /neighbourhood="10000"
                     /product="thioamitides"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12501
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and TfuA)"
                     /neighbourhood="10000"
                     /product="thioamitides"
                     /protocluster_number="1"
     misc_feature    1640..1653
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    2188..2201
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            2300..4165
                     /locus_tag="CMC5_RS20385"
                     /old_locus_tag="CMC5_041420"
     CDS             2300..4165
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008134 - transcription factor binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1112: sigma-54
                     dependent trancsriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025885.4"
                     /locus_tag="CMC5_RS20385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041420"
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="WP_050431983.1"
                     /transl_table=11
                     /translation="MSMESGKGRGVETCTERLPGEPELPSPPEMVLWLMVHYSDGVEPA
                     RLVAGQPLVVGRTDPSDLRIPDRTLSRTHARFTLSEGRIVVEDLRSTNGSFVAGKRIER
                     AEIEIGGEIMLGMVTVRVSAFGTIKDVSVEAEGQFRRRLEDEAARAHLFRRPFAVLAVR
                     IPGGGTERTTVGGWTHGLTTKLRLVDKLSLYTPDTALVLLPEMEREAALTAARGLATLR
                     AEGHAPFHVGVAVYPEAATTVDALIELARDAAARATPQNPVASASTAAWTEGPASDPGD
                     DMIVGKALRELHDTAERIAASELSVILHGETGTGKEVLAHFIHERSARRSKPMVCVNCG
                     AVPATLLESTLFGYEKGAFTGANQPQTGMFEAAHGGTLFLDEIGELSLAAQAALLRVLE
                     SGKLTRVGSTKEKDVDVRVIAATHCDLEEMVAEKTFRQDLYFRLNTMVLQLPPLRERVD
                     EIDKFVDRFRLRANKINKRHVKGISRDAAALLRAYTWPGNVRELRNVVDRAVVLARGEL
                     IQPEDLPSRLREANPAPSLQPDPALETPAQDSASLPEKAAPSSAVVLRQPSVPSAKIKA
                     QVSEFEAKKLRETLAEVGGSRAKAAEKLGMPLRTLSRKVKKYGLV"
     misc_feature    2933..2935
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4453..5019)
                     /locus_tag="CMC5_RS44745"
     CDS             complement(4453..5019)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS44745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_179955529.1"
                     /transl_table=11
                     /translation="MNGQRRTSRWAGALLGTLALSCASGCELIATADRSLITDTSGSAG
                     GTGDGGSGGTPSNTGGGGGAGGQGAAGGAGGQGGSGGQGGQGGTGGQGGMGGSGGQGGT
                     GGQGGMGGSGGQGAGGEGGSGGQGGGAGVGGSGGSGGSQGVGGSGGSGGQGGAGGSSGV
                     GGAGGSSGVGGAGGSSGVGGAGGGN"
     gene            5574..9191
                     /locus_tag="CMC5_RS20400"
                     /old_locus_tag="CMC5_041440"
     CDS             5574..9191
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019334.4"
                     /locus_tag="CMC5_RS20400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041440"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_169796601.1"
                     /sec_met_domain="Pkinase (E-value: 8.9e-30, bitscore:
                     102.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLGSYRVVGVLARGGMGLVYRGEHERSGEAVALKTVRSVVGDQL
                     ASIRREIQALRRVRHPGIVRILDDGVSEGLPWVAMPLLQGRTLRQHLASLWVEPSGEAR
                     GARGARGIAADSAGTAALATALLGDAAGRASDHAEDSAPGAVTPGMPDASREAAGTRPV
                     ARGAVLAGMLSLLRRLCEPLAFLHGEGLVHRDLKPENVFLQEDGRPVLVDLGIAAHVGD
                     AGGREVLEVALLQGTPQYMAPEQLRGELVDARADLYALGCILYECATGQPPFTGESFAS
                     VRHQHLHERPLPPSLRVPGLPVALDQLVLQLLEKRPEDRPGYAMDVAAALSALGADAGP
                     EAGRPDAGPTPRAYLYRPGLLGRAEAMTTLEEAIGAMARRERGGMVLVRGESGVGKTRL
                     LREMTRIAVQRSGSHQEITVLAGRCAALGTSEGSVRGEGSSGPLHAFRSVLMEVADRAR
                     AGGHEVSEHLLGPRGKILSVYEPALLGLPGQQEQPTPAALPPEAARARVIASLEETITA
                     LSASSPLLLVLDDLQWSDELSLSLVEALSRESEARRGVLVVATYRAEETRPELEALSAL
                     PGVRSIALSRLDAPSVKAMVSDMLALRTPPRGVLEALVGHSSGNPFFVAEYLRAAIGEG
                     MLRRDAAGRWQFEAGSPGSALSSLPLPDTLAALVERRLRRLEDGGRALLAWAAVLGQEL
                     ETELLLAGASSEAEAEEAIEALRVRQVLEAGPGGRLRFVHDKIREIAYERLGEAARLEL
                     HRKAGALLEARHGEARDMASTLAHHFLRGRVHGKAGRYFARAAERAREVYANGEAIRFY
                     QAGIEAVREEAARGGEFGEGEMPDLAALHERLGDVLGLVGRQGDARGAYEAALAVGPEP
                     PHLHPARLLRKLGESLELHHDHDAALSRYAEAEAALGERPAGRAAAWWDEWLLVQMNCI
                     AIHYWRADVERVRALVETIRPVVEENATAMQRAHFLSVLVKMNLQRERYATSAETVQLS
                     RACFAAFEQAEGTPEGLLSLRARFSLGFNLMMNDAHLEAEEQFSAVLHIAERTGDIEMQ
                     TRCLSYLAIVQRRLGRLLLAETLAERSLATARAAGMNEYAGAALGTLAWVALRRGHHDE
                     AAMRAQEALAHWAPSSHVYPFEWVARLPLLAHLLRVEAGDEDILVHLKAILDTRQQRLP
                     DAIADALSQAEEAGHRGSNEQARTALARAIEAAAEQGFA"
     gene            9317..9961
                     /locus_tag="CMC5_RS20405"
                     /old_locus_tag="CMC5_041450"
     CDS             9317..9961
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_041450"
                     /product="hypothetical protein"
                     /protein_id="WP_050431987.1"
                     /transl_table=11
                     /translation="MSIESLNVDDPRSFIFTIDGSPEPLYQVESRQWARPEYRWAASEI
                     PAEIRTKVAELESNGKPGAFVRFEDDQDGVYVICEQNIKMVPEVADEDVLIAGSLNASS
                     GRSLSHYDIVVHAKAGPVPSNGETLSTEIGEYYVIRYENWGRYVLHQSMRPQDVVTTKE
                     ILLLLERLHGTNFLSMTPDKPEEGLPPNVDGPTDAIVACNCYVLNLARFKR"
     misc_feature    9359..9373
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            10001..11323
                     /locus_tag="CMC5_RS20410"
                     /old_locus_tag="CMC5_041460"
     CDS             10001..11323
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thioamitides: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012233175.1"
                     /locus_tag="CMC5_RS20410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041460"
                     /product="YcaO-like family protein"
                     /protein_id="WP_082362647.1"
                     /sec_met_domain="YcaO (E-value: 2.6e-77, bitscore: 259.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPTPNATSPDPAAPPTAAGSAGPAAPLSPTPPAAKQFLAGTHRI
                     VAPEETVAHVRRLMPVMGITRIADVTGLDTLGVPVVMVTRPGARSISVSQGKGLTLDAA
                     RASGLMESVEHWHAEHVQLPLKLGTVNELRYRHRLIDVGRLPRLAIGAFHDNLRLFWVA
                     GMDLAVGAPTWVPFEIVHADYSLPLLAGTGCFVMNTSGLASGNHPHEAVSHGICELIER
                     DAATLWHLSSEAHKCATRVDLGTVDDLACRDILDRVTRAGVAVFVWEITSDVGVPAFSC
                     TIVDAEPNPYRTVAPMRGYGCHPSRGVALLRALTEAAQSRLTVITGARDDIRAQGNGPE
                     EDLRAARHFLSLHARQETPRRFDEAPDNPSETLDEDVAWELERLRAVGLDQVVTVDLSR
                     PELGVPVVRVVIPGLEPLYDVPGFVPGARARARWCAEEHAS"
     gene            11320..12501
                     /locus_tag="CMC5_RS41680"
                     /old_locus_tag="CMC5_041470"
     CDS             11320..12501
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thioamitides: TfuA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012239731.1"
                     /locus_tag="CMC5_RS41680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041470"
                     /product="TfuA-like protein"
                     /protein_id="WP_063796318.1"
                     /sec_met_domain="TfuA (E-value: 9.7e-46, bitscore: 153.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVFVFAGPTISAAEGEAHLSAVFLPPAAQGDLYRAALEKPAAIG
                     LIDGYFERIPSVAHKEILWAMAQGVHVFGAASMGALRAAELSLFGMEGVGAIFEGYLRG
                     ELEADDEVAVAHAAVEDDYRPLSEALVNVRATLRAAVRAGVIVEELRVQLEGIAARAFY
                     ADRCYPLLFEQAAQEGADPDALAALRTFLVEGRVDQKRLDALALLRVMRERFTEKVAPK
                     RVRYHFEPTDAWELIRESATHRVFEAGVCAVDPAVEALMRQGGKRYAAARRGALGRALS
                     LEAARRQNVASEGAVLTVAVESLCREHGLRSLSELRGWLAAQEVEEVDQFLKEEAQVRW
                     AALLYGQDTDRCLADHLRATGEYAGLRAGVVEGGVDVGAGETQGLKAVTEDGR"
     gene            12540..13721
                     /locus_tag="CMC5_RS20420"
                     /old_locus_tag="CMC5_041480"
     CDS             12540..13721
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_041480"
                     /product="hypothetical protein"
                     /protein_id="WP_156338743.1"
                     /transl_table=11
                     /translation="MSLLWLLTRRDHTGTRKELGDALEVVLKGELSLGEAKRAIDEVLE
                     RLTSTKVVDNARRVALRLTRTGQEAARAEVERLGIKLSPAGLSWRELKKRILSAPHVDL
                     TDGGKSSDAKVAETTSSAQAPVTKGEGKASSAKGNDALPGKADEIRAAILARRYQLDLG
                     PSPTLAQVRDALTWRQIEEITTEPFGITEVREVLLNRLLAREKGERLVLTNEKGKRLDW
                     KTVLNILAANAVGARKADAGELYAAFTRQWLRDSAGEGGAGPQHEEDSTTNGLSQTQDT
                     TVKPDTKPVIRNLVALPVDEAAFAARVKEAAKATKSGRVGEDKVLISHVRRRLEEEGAA
                     IDDVDAFKARLVSAHRKQLLSLGRADLVEAVAPEDVDASETHYMSSTFHFVRI"
     gene            13805..17077
                     /locus_tag="CMC5_RS20425"
                     /old_locus_tag="CMC5_041490"
     CDS             13805..17077
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002621452.1"
                     /locus_tag="CMC5_RS20425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041490"
                     /product="DUF87 domain-containing protein"
                     /protein_id="WP_050431989.1"
                     /transl_table=11
                     /translation="MAEHDALLDVFLSNTKKEVFHSVEHRHQIWRENPFDVECVHERAR
                     SEFQRQLAQITTPPGLDSGRILLLLGESGSGKTHLVRSFRNYVHRDGLGFVGYMQMTTA
                     VSYQRYLVSNLIDSLDQPYYESLGTTSGLTRLSIAVASRCGDPKSISELAENPDLSRDD
                     VVELVEEAADRLIANPRYADLDLDLIRALLYLQRQDPGLKKRVVKYLRCETLSERDSKF
                     LGGMTSKQGDEDAQKLVEHIGRLMWAFDSRALVICVDQFEDAYQSDEAEVLFRRAMTSL
                     CALADQVPSSLVVLACLEDYYTKLKPRLTRSTLDRIEHDPAPVRLLTERSAKEVEMIIR
                     QRLGHLYEASGLKAPNGALDTIYPFPLSFVRQLEGLRVRSVLDECRMYRDACIEAREVV
                     APPSSGTQRRHQKSAPDERLIKVAKEKLEQEWNDFLAQQQEEPPEEDEELAELFGWAIQ
                     AAAEELESGHRCEVQVKGSMIDVRVQVPLLGNKFRIGEEILVALCNKAPQGGGLKAQIQ
                     KAHELAGHRVAAMLRCGDFPSNQKTQVAQALAAILKKGGRKAVVEDSDWRKIGAFRRFR
                     NRAERREHFMAWLMEENHLSRLMPLIDVLDLDRMERFEPAVPVSQRPTVVIPPVCRPSR
                     PDEPVPSNFTEPDTMESVAPPRRVDPTPPPSPVVVEEGPVVLGVSGELVTQPVVIDMAA
                     LTSHAAFLGSTGSGKTTLALNLIEQLVLRGVPAILVDRKGDLCAYAREAPWNQRHPEPA
                     LEARRQALRERIDVAVFTPAHREGRQLALSLVPRGLDSLPDLERDAAAKYAAEALGDML
                     GYRQTRKDRGLRAVLVQAFLLFAENGNADRLNLKSLISFIGDEDPALVAALGRLDTKLF
                     KDLVQDLQVLLLSSSELLASDGERLDAELLLGLGPHARPGKTRISIISTKFLGDNARVL
                     FWVSQLLLTLTRWVTRAPSPRLQAVAMFDEADVYLPAQSQPATKGPMENLLRRARSGGL
                     GIFLATQSPGDLDYKCRDNIRSWFVGRVAQNVALEKMKPLFAEARVNVAGKIPGQGVGE
                     FHLLQDGRVTPFKAHQALLRTEQVPEHEILRLAALRRRAQAR"
     gene            17149..20913
                     /locus_tag="CMC5_RS20430"
                     /old_locus_tag="CMC5_041500"
     CDS             17149..20913
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF017539.4"
                     /locus_tag="CMC5_RS20430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041500"
                     /product="effector-associated domain EAD1-containing
                     protein"
                     /protein_id="WP_050431990.1"
                     /transl_table=11
                     /translation="MDGEIINFEEEQYRHERLFARQDVLDRLQGWLVGERALYRGWVFL
                     LGGPGVGKSAILAELLKVLPEQTPRHFIRRGNEGWDRPEVMVQNLCAQIERLFSEPVDT
                     SLPLDARLGDLLRRVSRKMLDPYKQRLVLVLDGLDEAVSDTAGKNPLPRFLPRVLPPGV
                     VLLCASRPVHPDLDGLLQHDKVQRIDLDDGAWTASNEAACRAFWEHYAATFDPPLDATF
                     VREAVRRAGGNLLHAIRLRDWLEDQPPERRIVKNIPKQLSGFLSQIWSELLKLDDARST
                     LVVTGLGVACAAREALPAYLFRELLEWSSSSEEEDFLRVTRPFLRQENAHWHPDCPAYR
                     LYHEYFREFIVWQLGEPRIRELNRLLASTLAQWPSIAGTSSHRGYALRHAVTHRIEGGM
                     LEEARTLCTNVVYMEEKCRGLGVAAVERDLEAVIRASGAEGSLDLATVLAALGAEASRL
                     RASPALLPALLYNRLRCAGWSPDRIGTVLHFPAGLPSLRLRHGVRLGPTLLHTFVGHER
                     PVSACGVTPDDGLLLSASADRTLRLWALGSGEPLAVLRGHEDEVTSCAITADGKMAVSS
                     SVDATLRVWDLTAQRCLVSLEHEGRWVTACAVSPDGKRVVGGLDNGRITVWDRASRRLV
                     GSLQGHADYVTACQVTADGKRVVSASRDRTVRVWDIASGACTHTLRREDVVGSKVPAER
                     EEAGWMTALLLLHGGLQAVSVAGDGLVMRWDLGTGHCAQRFGAGQGRVDACALLHDGRH
                     LVCGMADGSIHVWDLGGGRLLRRMDAAHGGPVSALSATRDGRRLVSASSDRGLKLWDLG
                     GPEGLSARGRHTAPVAACAVTPDGRWAVSASEDRTLKIWDVRTGACRGTLPKHEALVTA
                     CAISADGQRVLSGASDGSVRLLRLGAKDAEPIRSHEALVSGAALLGDGRIVTASANGEI
                     GIAVPATSEALVAFRGDFGPVVGCAMTPDGAHALTISREGPPVLWDLSTRAPRLVLSDA
                     TAVFLSCALSRNGDRTVLGREDGVVEVRDLVSGQVLHELRGHTSRVFGCAISPDETRVI
                     SASEDETLRVWSLESGECLGMVQGTSWFRCVAVGQGVICAGDQEGDLWMIASEKQESFL
                     LPPKPPIPPAQPNPPGPEMPHPPKRLNQPIESGATATGIMVPPPEPPRQPPSSDPWNDS
                     AMVLARLRDVLAKIYDSEVSARRLVMDVGLDERRILFIGTLQDIWHAILREAVKTDRVA
                     LLMEWVLGEYPENPALIDFKRRFFSHGRV"
     misc_feature    20920..20933
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    20929..20943
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            20961..21986
                     /locus_tag="CMC5_RS20435"
                     /old_locus_tag="CMC5_041510"
     CDS             20961..21986
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017270711.1"
                     /locus_tag="CMC5_RS20435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_041510"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_050431991.1"
                     /transl_table=11
                     /translation="MNAEPRWRDSASRAAWRNALARKYPTTDEARVFIDHVGLSPIRIA
                     FSNRADLTWFAILEEAQRQGPRWVLAVLDRALEDFPDDDALRRLRDGEPVRYAEGPDAN
                     ALGWRGRGGQTLEKILGKVSTLVPVSFLEVGMRRAHAVVRVRCADGSLGSGFLATDDLL
                     VTNHHVLSTRAAATTARVQFNYQKTIEGRDAEMEEFLLDPDAFFATSAADDCTLVKVQG
                     NPSSRWGAIDLQPAPITRDDRVNIIQHPGGDQKQLSFFHNLVVYAGEGRLQYLTDTLPG
                     SSGSPVFDREWRLVAIHHSGGWVVEPGTREQFYRNEGILAERILALLHTAREPSACGVT
                     T"
ORIGIN
        1 cctgcggaag gcgagcaaga gcggcagacc ggcgaggagc cagagcgcgc tggtggcacg
       61 ggcgctgtcg gtacgtggga aggcgcagga gaagccgccg ccgtggaggc tgggctcggt
      121 gggcgttgcg ccattgcccc cctggccgct gcctggagtg cccgcgccag cgccattgcc
      181 cgccccggag ccacccgaag gcgcgccgcc cccgttgccg ctgccgccga cgcccgtggt
      241 gctgccgcct ccttcgcccg agctgctgct ctcgacgaga cagccaccgg cgatgcagac
      301 gccgccagga caaggggcgc cctcgttgga gtagggggcg cactcgccgg tggtggggta
      361 gcaggccatc acctggcaga cgttctggga cggtgcacag acgacgggct gggtgccgat
      421 acagacgccg ctctgacaga tgtcgacggc ggtgcaggct tgcccatcgt cgcaagacga
      481 gccatcgggg cgcggcggat cgttgcaaga gcaggcgtcg ccgacgccat cgccattgat
      541 gtcctcctgc gaaggattgg gcgtgcgcgg acagttgtcg ctggcattgg gcaccccatc
      601 gccgtcgatg tcgtcgtcgc aggcgtcacc gatgccgtcg ccatcgagat cggcctggct
      661 cgggttgtag acgtcggggc agttgtcgac ggcgtcggcg atgccgtcgc ggtcgcgatc
      721 ggcgatcgcg caagagccat tctggcaaac gccgccattg ccgcagggcg atccattggg
      781 ccgcacgggg tggttgcatg cgccggtggt gggattgcac gcgccctgct cgtggcaatc
      841 gtcgggcggc gggcattgca caggagtccc cgggacgcag gtgccggcat tgcatctgtc
      901 ggtctgggtg caggcattgc cgtcgttgca ggacgcgcca tcgggtttcg ggaccggcga
      961 gcagtcaccg gtggcgagat tgcacacccc ctgctcgtgg caatcgttga tgggcgcgca
     1021 catctgcggg ctgttgcccg agcaggtccc ggcctggcag gtgtcggtct cggtgcagag
     1081 attgtcgtcg gtgcaggcac taccatcggg cgcgggcggt gagacgcagg tgcccgtggc
     1141 ggggttgcat gtgccctgga ggtggcaaac tggcggagcc gggcagacca cgggattcgt
     1201 cccggtgcag actccgctct ggcacgtgtc ggattgcgta caggcattgc cgtcgttgca
     1261 cgccgtcccg ttcggtcgac tcggcgtgga gcacatcccg ttcgcggggt tgcaggtccc
     1321 ggcgtcgtga caggcgtcga tggcagggca ggccttgggg gcgccgggcg tgcaggcgcc
     1381 gttcacgcag gtgtcgttct cggtgcaggc gttgccgtcg ttgcacgcca ggttgttgtt
     1441 gctccggacg caggtgttgt tgacgcacga gtcggtggtg caggggttgc cgtcgtcgca
     1501 ctgcgcgccg gtcgtgcacc tgcccgtcgc ccagagccac gtgtcgctgt acgtggcgct
     1561 tccgccgtat tcgtagaccg cccccgccca caggtcgtcg ttgccgaacg tgaccatccc
     1621 gatcggctcc cccagggtat cgatgccgat gaacgacgcg tttcccgccg gcgtccaggt
     1681 cacctggccg agcatcgtcc cgttggtccc ccaggcggtg aggtactgcc ttccattcac
     1741 gctcgcggtc aggccgacct gcgtcacatt ctgaaggaag gtcgcggtca tggtgtagta
     1801 ggcgtactgg cccacgtggg agccgccccc caggggcgag gggaaattgc cggcgctggg
     1861 gctgtaggac gggaagttgc cggtccccgg ggtggtgcag ccgggcagga tcacggagag
     1921 ttctccgctc cgccacagca gtccttgcgc ggcgtagatg tcgttgggca cctggcccga
     1981 cgtgggtccc tcgtcgaagt caccgcgtcc gatgacatcg atcatctggc tgacgtgcgt
     2041 cagggcctgg acgttgccga cggctgtgat cgactgggcc cacgccgacc ccgcaatgcc
     2101 caggaccggc agagccaccg ccgccagggt gaggccccgc aacacgattc ccatcaagcc
     2161 aggctactcc gattcgtgct gcgtgggggc actcaccttg caaggacgtc cctccatgaa
     2221 gccgtgggaa ggactaccag gtagcgggat gcgctctcgg atgcacgaac ctgggtcatg
     2281 cgaagtagga tgggggttca tgtccatgga gagtgggaag ggcagggggg tggagacctg
     2341 caccgagagg ctacctgggg agcccgaact gccgagcccg ccggagatgg ttctctggct
     2401 gatggtgcat tacagcgacg gtgtggagcc ggcgcggctc gtggcggggc agccgctggt
     2461 cgtgggccgt accgacccgt cggacctgcg catcccggac cgaacccttt cgcgcacgca
     2521 cgcgcggttc accctgtcgg agggccggat cgtcgtcgaa gacctccgat cgacgaacgg
     2581 cagcttcgtc gctggcaagc ggatcgagcg ggccgagatc gagatcggcg gcgagatcat
     2641 gctgggcatg gtcaccgtgc gtgtcagcgc cttcggcacc atcaaggatg tctcggtgga
     2701 ggccgaaggg cagttccggc gaaggctcga agacgaggcc gcgcgcgcgc acctcttccg
     2761 ccgccccttc gccgtcctgg cagtgcggat cccgggcggc ggcaccgagc gcaccaccgt
     2821 cggcggctgg acacacggcc tgacgacgaa gctgcgcctc gtcgacaagc tgagcctgta
     2881 caccccggac accgccctgg tcttgctccc cgagatggag cgcgaggctg ccttaaccgc
     2941 ggccagagga ctcgcgaccc tccgcgccga gggccacgcg cccttccacg tgggcgtcgc
     3001 cgtttacccc gaggcggcga cgacggtgga cgccttgatc gagctggcgc gggacgctgc
     3061 ggcgcgtgcg acccctcaga atcctgtggc gtccgcctcc acggccgcct ggaccgaggg
     3121 cccggcctcc gatccgggcg acgacatgat cgtgggcaag gcacttcggg agctgcacga
     3181 caccgccgag cgcatcgccg cttcggagct gagcgtgatc cttcacggcg agaccgggac
     3241 gggcaaggag gtgctcgccc atttcatcca cgagcgcagc gcacggcgga gcaagccgat
     3301 ggtctgcgtc aactgcggtg ccgttccggc cacgctgctg gagagcaccc tgttcggcta
     3361 cgagaagggc gcgttcaccg gcgcgaacca gccgcagacc ggcatgttcg aagcggctca
     3421 cggcggcacc ctcttcctcg acgagatcgg cgagctgtcc ctcgccgcac aggctgccct
     3481 cctgcgcgtc ctcgagagcg gcaagctgac ccgcgtcggc tcgacgaagg agaaggacgt
     3541 cgacgtccgc gtcatcgcgg ccacgcactg cgacctggag gagatggtcg cggagaagac
     3601 gttccgtcag gacctctatt tccggctgaa caccatggtc ctccagctcc cccccttgcg
     3661 agagcgggtc gacgagatcg acaagttcgt cgaccgcttc cggctgaggg cgaacaagat
     3721 caacaagcgc cacgtgaagg gcatttctcg ggacgccgcc gcgctgctgc gcgcctacac
     3781 ctggccaggg aacgtgcgcg agctgcgcaa cgtcgtggac cgggccgtgg tcctggcccg
     3841 cggggagctc atccagcccg aggatctccc ctcccgcttg cgcgaggcga acccagcccc
     3901 ctccctccag cccgaccccg cgctggagac gccagcccag gacagcgcat cgttgcccga
     3961 gaaggcggcg cccagttccg ccgtggtgct gcggcaacct tccgtccctt cagccaagat
     4021 caaggcgcag gtctccgagt tcgaagcgaa gaagctgcga gagaccctgg ccgaggtggg
     4081 aggcagccgc gccaaggccg ccgagaagct cgggatgccg ctccgcaccc tgtcccgcaa
     4141 agtgaagaag tacggtctcg tgtagcgcgc ccacgggcca cgagctttcg tgcttcagcg
     4201 tccgcgaggg agccggacgc cgaaaccccg acagatcccg cgggatcatc cccccggtcg
     4261 cgcgttctgg acctcggcgc gacgtgatcg agccagctgc acggcggcgg ggacctcagc
     4321 gcaacctgat cgagccagct gcacggcggc ggggacctca gcgcaacctg atcgagccag
     4381 cggcacggcg gcggggaccc cagcgcagcg tgatcgagcc agcggcacgg cggcggggac
     4441 cccagcgcag cgtcagttgc cgccgcccgc gccgccgacg ccgctgcttc cgcccgcgcc
     4501 gccgacgccg ctgcttccgc ccgcgccgcc gacgccgctg cttccgcccg cgcctccttg
     4561 accaccggag ccgcccgagc cgccaacacc ctggcttcct cccgagccac ccgagccacc
     4621 gacgccggct ccgccgccct gtccgccgga gccgccctct ccaccggcgc cctgtccgcc
     4681 ggagccgccc atgccgcctt ggccgccggt accgccctgc ccgccggagc cgcccatgcc
     4741 accttggccg cctgtgccgc cctgtccgcc ctgtccgccg gagccgccct gaccgccagc
     4801 gccgcctgcg gcaccctgtc cacctgcgcc gcctcctccg cccgtgttcg agggcgttcc
     4861 accggagccg ccgtcacccg ttccgccggc ggagccgctc gtgtccgtga tcaggctccg
     4921 atccgcggtc gcaatcagct cgcagccgct cgcgcaagag agggcgaggg tcccgaggag
     4981 ggcaccggcc cacctgctgg ttcgtcgttg gccattcatg gtggccacac ccacaacatg
     5041 ccaggtccgg cgtcaacctc ctccgaatcc gacctcactg aaggcccccc ggcaggacct
     5101 ccctgctggc cacggatggc cagtctctgg ccagcagcct ggccaggctt ggccagccag
     5161 catcgtcgtg atctggccat cgatggcagc gcacggccat ccagggattt ctggcgatgg
     5221 cacgaagcct gctccagcgg atcatcgacg tgaacacacg gacctgcgcc acaacgatgc
     5281 tccgcgccac gccgccagac cggctgcatc gcgcaccgcc accgcacgga gcgccatcct
     5341 catcgggggc gagcacggtg gcgtcgaacg gcgtgccggc cgcaccggga gcgagcgcgg
     5401 gggcaccgtg ggaagcgctt actccgcagc ggggcacctt ctcgctgcag ccgggagcgc
     5461 cctcgccttg ccggcgtgaa cctctgggcg aaggggtgcg tccgggtggg gtagcatcgc
     5521 gcccggtgat gagcgttacg cagccagcag acctcctccg ggcggatgcg tcgatgatgt
     5581 tgggttccta tcgtgtcgtg ggtgtgctgg cgcgcggggg catgggcctc gtgtaccgcg
     5641 gggagcacga gcgctctggc gaggccgtgg ccttgaagac ggtgcgctct gtcgtgggcg
     5701 atcagctcgc cagcatccgg cgcgagatcc aggcgctgcg gcgggtgcgg cacccgggca
     5761 tcgtgcgcat cctcgacgac ggcgtgtcgg aggggctgcc ctgggtggcc atgccgctcc
     5821 tgcaaggtcg cacgctgcgg cagcacctcg cctcgctgtg ggtcgagccg tcgggcgagg
     5881 cgcgcggggc gcgcggggcg cgcgggatcg ccgcagacag cgcggggacg gcggcgctcg
     5941 cgacggcgtt gctcggtgat gcggctggtc gcgcgtcgga ccatgcggag gactccgcgc
     6001 ccggcgccgt cacgccaggg atgccggatg cctcgagaga ggcggcaggg acccgtcctg
     6061 tagcgcgtgg cgcggtgctc gcggggatgc tgtcgctgct gcgacgcctg tgcgagcccc
     6121 tcgcgttcct gcacggcgag gggttggtgc accgggatct caagcccgag aacgtattcc
     6181 tccaggaaga cgggaggccc gtgctggtcg atctggggat cgccgcgcac gtgggcgacg
     6241 ccggagggcg tgaggtgctc gaggtggcac tcctccaggg gacgcctcag tacatggcgc
     6301 cagagcagct ccgtggcgag ctggtcgacg cacgggccga tctctacgcg ctcggttgca
     6361 tcctgtacga gtgcgcgacg ggacagccgc cgttcacggg ggagagcttc gcctcggtgc
     6421 gccaccagca cctgcacgag cggcccctgc cgccctcgct gcgtgttcca gggctgcccg
     6481 tcgcgctcga tcagctcgtg ctccagctcc tggagaagcg gccggaggat cggccgggct
     6541 acgcgatgga tgtcgcggcg gcgctctcgg cgctcggtgc cgacgcaggc ccggaagcag
     6601 ggcgccccga cgcggggccg acgccgcggg catacctgta ccggccggga ctcctgggtc
     6661 gcgccgaggc gatgaccact ctggaggagg cgatcggcgc gatggcccgc cgagagcgcg
     6721 ggggcatggt gctggttcgg ggcgagagcg gcgtgggcaa gacgcgcctc ttgcgggaga
     6781 tgacgcggat cgccgtccag cggagcggct cccaccagga aatcaccgtg ctcgcggggc
     6841 gctgcgccgc gctcgggacc agtgagggga gcgtgcgcgg cgaggggagc agcggccccc
     6901 tgcacgcctt ccgctcggtg ctcatggagg tggcggaccg cgcgcgcgcc ggcggccacg
     6961 aggtgtccga gcatttgctc gggccgcgcg gcaagatcct gtcggtctac gagcccgcac
     7021 tcctgggtct gccaggtcag caggagcagc ccacaccagc ggcgctaccc ccggaggccg
     7081 cgcgggcccg cgtgatcgcg tcgctggagg agacgatcac ggccctgtcg gcgtcgtccc
     7141 cgctgctcct ggtgctcgac gatctgcagt ggagcgacga gctgtcgttg agcctcgtgg
     7201 aggcgctctc gcgcgagagc gaggcgcgcc gcggcgtgct ggtcgtcgcg acctacaggg
     7261 cggaggagac gcggcccgaa ctggaggcgc tgtccgcgct ccccggggtg aggtcgatcg
     7321 cgctgagccg cctggacgcg ccgagcgtca aggcgatggt ctccgacatg ctcgccctgc
     7381 ggacaccgcc gcgcggggtg ctggaggcgc tggtcgggca ctcgagcggc aacccgttct
     7441 tcgtggcgga gtacctgcgg gcggcgatcg gtgaggggat gctgcggcgc gacgcagccg
     7501 ggcggtggca gttcgaggcc gggagcccgg gatccgccct gtcgtcgctc ccgctgcccg
     7561 acacgctcgc cgcgctggtg gagcggcggc tgcggcggct ggaagacggc ggccgtgcgc
     7621 tgctggcctg ggccgcagtg ctgggtcaag agctggagac ggagctgctc ctcgccggcg
     7681 cctcgagcga ggcagaggcc gaggaagcca tcgaggcgct gcgggtccgg caagtgctgg
     7741 aagctggacc gggtggaagg ctgcggttcg tgcacgacaa gatccgcgag atcgcctacg
     7801 agcgccttgg cgaagccgcg cgcctggagc tgcaccgcaa ggcaggggcg ctgctggagg
     7861 cgcgccacgg cgaggcgcgc gacatggcgt cgaccctggc gcaccatttc ctgcgcggtc
     7921 gtgtgcacgg caaggctggg cggtacttcg cgcgtgccgc ggagcgagca cgggaggtct
     7981 acgcgaacgg cgaggccatc cggttctacc aggcgggcat cgaggcggtc cgagaagagg
     8041 cggcccgtgg tggcgagttc ggcgaagggg agatgccgga tctcgctgcc ctgcacgagc
     8101 ggctcggcga cgtgctcggg ctggtagggc gccagggcga cgcgcgcggc gcgtacgagg
     8161 ccgcgctcgc cgtggggccc gagcctccgc atctccatcc ggcgcggctg ttgcgtaagc
     8221 tcggagaaag tctggagctg caccacgatc atgacgcagc cctctcgcgg tacgcggagg
     8281 ccgaggctgc gctgggcgag aggccagccg gtcgtgccgc ggcctggtgg gacgagtggc
     8341 tgctcgtgca gatgaactgc atcgccattc attactggcg tgcggacgtc gagcgcgtgc
     8401 gcgcgctggt cgagacgatt cgccctgtgg tcgaagagaa cgcgacggcc atgcagcgcg
     8461 cacacttctt gagcgtgctg gtgaagatga acctccagcg agagcgctac gcgacctctg
     8521 ccgagaccgt gcagctctcg cgtgcctgct tcgccgcctt cgagcaagcc gagggcaccc
     8581 cggagggact cctctcgttg agggcgcgct tcagcttggg gttcaacctc atgatgaatg
     8641 acgcccacct ggaggccgag gagcagttca gcgccgtgct gcacatcgcc gagcgcaccg
     8701 gggacatcga gatgcagacg cgctgcctgt cttacctggc gatcgtccag cggcgattgg
     8761 gtcggctgct gctcgccgag accctggccg agcggagcct ggccaccgcc cgggccgcgg
     8821 gaatgaacga gtacgctggc gccgccctgg ggacgctggc ctgggtcgcg cttcgccgcg
     8881 gtcaccacga cgaggcggcg atgcgcgccc aggaagccct cgcgcactgg gctccctcgt
     8941 cgcacgtcta cccgttcgag tgggtcgcgc gcctgcccct cctcgcgcat ctcctccgcg
     9001 tggaggccgg agacgaagac attttggttc acctgaaggc cattctcgac acccggcagc
     9061 agcgcttgcc ggatgcgatc gcagacgcgc tgagccaggc agaggaagct ggacaccgcg
     9121 ggtcgaacga acaggcccgc accgcgctcg cgcgggcgat cgaggccgct gcggagcagg
     9181 gattcgcttg agctgattcg cgcctttcga gttcgtcccg gcgttgccgg gcattgattt
     9241 cgcggcaggc gaggcatgcg gcctcgctgg ttcgccgcgt catggacccg tccgtgcgga
     9301 cgggaggagc agtgtcatgt ccatcgagag tctgaacgtc gacgatccgc gcagtttcat
     9361 cttcaccatc gatggctctc cggagcctct gtatcaggtc gagtcgaggc agtgggcacg
     9421 cccggaatac cgctgggcgg cgtcggagat cccggccgag atccgcacca aggtcgccga
     9481 gctggaatcg aacgggaagc ccggcgcctt cgtgcggttc gaggatgacc aagatggcgt
     9541 ctacgtcatc tgtgaacaga acatcaaaat ggtccccgag gtggccgacg aggatgtgct
     9601 catcgcaggg agcctcaatg cgagcagcgg ccgctccctt tctcattacg acatcgtcgt
     9661 ccacgcgaag gccggtccag ttcccagcaa tggcgagacg ctctcgaccg agatcggtga
     9721 atattacgtc attcgctacg agaactgggg ccgctacgtg ctccatcaga gcatgcggcc
     9781 ccaggacgtc gtgacgacca aggagatcct gctcctgctc gagcgacttc acgggacgaa
     9841 cttcctgtcg atgacgcccg acaagccgga ggagggcctc cctccgaacg tcgatgggcc
     9901 gaccgacgca atcgtcgcct gcaattgcta cgtcctcaac ctggcgcgct tcaagcgctg
     9961 aacccaccga ttgcagctct ccgacgattg aagaggcacc atgaatccca ccccgaacgc
    10021 aacctctccg gaccccgcgg ccccccccac cgccgcggga tcggcggggc ccgcagcccc
    10081 cctgagcccc acgccgccgg ccgcaaagca gttcctcgcc ggcacccacc ggatcgtcgc
    10141 tcctgaagag acggtggcgc acgtccggag gttgatgccg gtgatgggaa tcacccgcat
    10201 cgccgacgtc accggcctcg acacgctcgg cgtgcccgtg gtcatggtga cgcggccagg
    10261 tgcccgctcg atctcggtct cgcagggcaa ggggctgacg ctcgacgcgg cccgcgcctc
    10321 ggggttgatg gagtcggtcg aacactggca cgcggagcac gtgcagctcc ccctcaagct
    10381 ggggaccgtc aacgagctcc gctaccggca ccggctgatc gacgtcggcc gcctaccgcg
    10441 cctcgccatc ggggcattcc acgacaacct gcgcctgttc tgggtggcgg ggatggacct
    10501 cgcggtgggc gcgccgacgt gggtgccctt cgagatcgtg cacgccgact actcgttgcc
    10561 gctccttgct ggcacgggct gcttcgtgat gaacacgagc ggcctggcct cgggcaacca
    10621 cccgcacgag gcggtcagcc acgggatctg cgagctgatc gagcgtgacg cggccacctt
    10681 gtggcacctg tcgagcgagg cgcacaagtg cgccacccgc gtcgacctgg gcacggtgga
    10741 cgacctggcc tgccgtgaca tcctcgaccg ggtgacgcgg gccggggtgg cggtcttcgt
    10801 ctgggaaatc acctccgacg tgggcgtgcc ggccttctcc tgcacgatcg tggacgcgga
    10861 gcccaacccc taccgcaccg tggcgccgat gcgcggttac ggctgtcacc cctcgcgcgg
    10921 ggtggccctg ctgcgggccc tgacggaggc cgcgcagagc cgattgacgg tgatcaccgg
    10981 cgcgcgtgac gacatccggg cgcaagggaa cggccccgaa gaagatctgc gcgccgcgcg
    11041 gcatttcctt tcactccatg ccaggcagga gacgcctcgc cggttcgacg aggcgcccga
    11101 caacccgagc gagacgctcg acgaggacgt ggcctgggag ctggagcgcc tgcgcgccgt
    11161 gggcctcgac caggtggtca ccgtcgatct ctcccgcccc gagctgggcg tgccggtggt
    11221 gcgggtggtg atcccagggc tcgagcccct ctacgacgtg cccggcttcg tgcccggtgc
    11281 gcgggcgcgg gcgcggtggt gcgccgagga gcatgcgtcg tgaccgtgtt cgtcttcgca
    11341 gggccgacga tctcggccgc cgaaggggag gcgcacctgt ccgcggtgtt cctgcccccc
    11401 gccgcccaag gcgatctgta ccgcgccgcg ctggagaagc cggccgcgat cggactgatc
    11461 gacggctact tcgagcgcat cccgtcggtc gcccacaagg agatcctctg ggcgatggcg
    11521 caaggggtgc acgtgttcgg cgccgcgagc atgggggcgc tgcgcgcagc cgagctgtcg
    11581 ctgttcggga tggagggcgt gggcgccatc ttcgaggggt atctccgcgg ggagctcgag
    11641 gccgacgacg aggtggccgt ggcccacgcc gccgtggaag acgactaccg gcccctgagc
    11701 gaggccctgg tgaacgtgcg cgcgaccctg cgggccgccg tgcgcgcggg ggtgatcgtg
    11761 gaggaattgc gcgtgcagct cgaagggatc gcggcgcggg cgttctacgc ggaccgctgc
    11821 tatccgctgc tgttcgagca ggccgcccag gagggggctg accctgatgc gctcgcggca
    11881 ctgcgcacct ttctggtgga ggggcgggtg gaccagaagc ggctggacgc actggcgctg
    11941 ctgcgggtga tgcgggagcg gttcaccgag aaggtggcac cgaagcgcgt tcggtaccac
    12001 ttcgagccca ccgatgcgtg ggagctgatc cgggagagcg cgacgcaccg ggtgttcgag
    12061 gccggtgtct gcgcggtgga tccggcggtg gaggcgctga tgcggcaagg ggggaagcgc
    12121 tatgcggcag cgcgtcgggg ggcactgggg cgagcgttgt cgctcgaggc cgcgcggcgg
    12181 cagaacgtgg cgtccgaggg agcagtgctc acggtggcgg tggagtcgct gtgccgggag
    12241 cacggtctgc gcagcttgag cgagctgagg ggatggctcg ccgcgcagga ggtggaggag
    12301 gtggatcagt tcctgaagga agaggcgcaa gtgcgctggg ccgcgctgct ctacgggcag
    12361 gacacggatc ggtgcctggc ggaccacctg cgggcgacgg gggaatacgc ggggctgcgg
    12421 gcgggggtgg tggagggggg cgtggatgtt ggggcggggg aaacgcaggg cctgaaggcc
    12481 gtgacggagg atggacgatg agtgcttcgg ggaagacggc ggtggcgcga ctcgggaagt
    12541 tgagcctgct gtggttgctg acgcggcggg accacacggg gacacggaag gaactcggtg
    12601 atgcgctgga ggtggtgctc aagggcgagc tgagtctggg ggaggcgaaa agagcgattg
    12661 atgaggtcct ggagcggctg acatcgacga aggtcgtcga taatgcgcga agggtcgcgc
    12721 tgaggctgac gagaactggg caggaggccg cgcgagccga ggtagagcgg ttggggatca
    12781 agttgtcccc cgcaggcctg agctggcggg agctcaagaa gcgcatcttg agcgcgcccc
    12841 atgtggacct gacggatggt ggtaagtcga gcgatgcgaa ggtagctgag acgacgagca
    12901 gcgcccaggc gcccgtcacg aagggtgagg gtaaggcgtc gagcgccaag gggaacgatg
    12961 cgctgcctgg gaaagcggac gagatccggg cagcgattct tgcgaggaga taccagctcg
    13021 acctcgggcc ttcgcccacg ctcgcccagg ttcgcgatgc actcacatgg cggcaaatcg
    13081 aggagatcac gacggaaccc ttcgggatca cagaggtgcg ggaggtgctg ttgaatcgtt
    13141 tgctggcgcg ggaaaagggt gagcgtctgg tgctgacgaa tgagaaaggc aaacggttgg
    13201 actggaagac ggtgctcaac atccttgccg cgaatgcggt gggcgctcgg aaggccgacg
    13261 ctggtgagct gtacgcagca ttcacccggc aatggctgcg ggattctgca ggtgagggag
    13321 gtgcgggacc gcagcacgag gaggactcga cgacgaatgg tctcagccag acgcaggaca
    13381 ccaccgtcaa gcccgacacc aagcccgtca tcaggaatct ggtcgcgctg ccggtcgatg
    13441 aagctgcctt cgctgcacgt gtcaaggagg cggcaaaggc gacgaaatca gggcgggtcg
    13501 gggaggacaa ggtgctcatc tcgcacgtgc gccgccgtct ggaggaagag ggcgctgcga
    13561 tcgatgatgt cgacgctttc aaagcaagac tcgtatcggc gcaccgaaag caactcctct
    13621 cgctcggccg tgctgatctc gtcgaggcgg tggcgccgga ggatgtcgat gcttcggaga
    13681 cgcactacat gagttccacg ttccatttcg ttcgtatcta ggttcgggac ggcgacgcag
    13741 agagcccctc cggtttcatc gagtgggtag cgcgtcgcga aagaaggaag ggatgggtag
    13801 gcccatggcg gagcatgacg ccctgctgga cgtgttcctg tcgaacacga agaaggaagt
    13861 gttccattcg gtggagcacc ggcaccagat ctggcgggag aacccattcg acgtcgaatg
    13921 cgtccacgag cgagcgcgtt cggagtttca gcggcagctc gcgcagatca cgacgccgcc
    13981 tgggctggac tcgggtcgca tcttgctgct cctcggcgag tcggggagcg gcaagacaca
    14041 ccttgtccga tcatttcgca actacgttca ccgcgatggg ctggggttcg tcggctacat
    14101 gcagatgacg acggcggtat cataccagcg ctatctggtg agcaacctga tcgattcgct
    14161 ggatcagcct tactatgaat ctctgggaac gacctccggg ctgacacggc tttcaatagc
    14221 cgtcgcttcc aggtgtgggg acccgaagag catcagcgag ctggccgaga atcccgatct
    14281 ctcccgcgat gatgtcgtcg agctcgtcga agaagcagcg gaccgcctga tagccaatcc
    14341 acgttacgct gacctcgatc tggatctgat ccgggccttg ctctacctcc agcggcagga
    14401 tccgggtctc aagaaacggg tcgtgaagta cctacgctgc gagacactct ccgagcggga
    14461 tagcaaattc ctgggaggaa tgacctcgaa gcaaggagac gaggacgcac agaagctcgt
    14521 cgagcacatc ggccggctga tgtgggcctt tgattcgcgc gccctcgtca tctgtgtcga
    14581 tcagttcgaa gacgcgtacc aaagtgatga ggccgaggtg ctgttccggc gtgccatgac
    14641 ctcgctctgc gctctcgccg accaggtgcc gtcgtctctc gtcgtgcttg cgtgcctcga
    14701 agactattac accaagctca agccccggct cacccgctcc acgctcgatc gcatagagca
    14761 tgatccggct ccggtgcggc tattgaccga gcggagcgcg aaggaggtcg agatgatcat
    14821 ccggcagcgc ctcggtcacc tctatgaggc gtcgggcctc aaggcgccga acggtgcgct
    14881 cgacaccatt tatccctttc cactgtcgtt cgtcagacag ctcgaagggc ttcgcgtgcg
    14941 ctcggtgctc gacgagtgtc gcatgtaccg ggatgcctgt atcgaggcac gtgaggtcgt
    15001 tgcgccacca agcagcggca cccagcgccg ccaccaaaaa tctgcgcccg acgagcggct
    15061 catcaaggta gcgaaggaga agctcgagca ggagtggaat gacttcctgg cccagcagca
    15121 agaggagcca cccgaagagg atgaggaact cgcggaactc ttcggctggg ccatccaggc
    15181 ggccgccgag gaactggaga gcggccaccg ctgcgaagtc caggtcaagg ggtcgatgat
    15241 cgatgtccgg gtccaggtgc cgctgctcgg caacaagttc cggatcggtg aggagatact
    15301 cgtggcgctg tgcaacaagg cgccgcaggg gggaggactc aaggcgcaga tccagaaggc
    15361 acacgagctg gcaggccacc gtgtcgcggc aatgctccgc tgcggcgact ttccaagcaa
    15421 tcagaagaca caggttgcgc aggcgctcgc tgccatcctg aagaaggggg gcaggaaggc
    15481 cgtcgtcgag gacagtgact ggcgcaagat cggagcgttc cggaggttcc ggaacagggc
    15541 cgagcgacgg gagcacttca tggcctggct catggaggaa aaccacctgt cgcggctgat
    15601 gccgctcatc gacgtgctcg atctcgaccg gatggagcgc ttcgagccag ccgtcccggt
    15661 gagccagcgg ccgaccgtag taattccgcc cgtgtgccga ccttccaggc ccgacgagcc
    15721 ggtcccctcg aacttcacgg agccggatac gatggagagc gttgcccctc ctcggcgcgt
    15781 ggatcctact ccgcccccca gtccggtcgt ggtggaggaa ggtcccgtcg tgctgggcgt
    15841 ctcgggggag ctcgtcaccc agcccgtcgt catcgacatg gcggcgctca cctcccacgc
    15901 ggcgttcctt ggtagcacgg ggagcggcaa gacgacgctg gcgctcaacc tcatcgagca
    15961 gctcgtactt cgcggcgttc cggcgatcct cgtcgaccgc aagggagatc tctgtgcgta
    16021 cgctcgcgag gcaccctgga accagcggca tcccgagccc gcgctggaag caagacggca
    16081 ggcgttgcgc gagcgcatcg acgtcgcggt cttcacgcct gcccacaggg aaggtcgtca
    16141 gcttgcactt tccctggtgc cgcgtggtct cgactcgctg cccgacctgg agcgagacgc
    16201 cgcggcgaag tacgcggccg aggcgctggg tgacatgctc ggctatcgac agacccgcaa
    16261 agacaggggg ctacgggccg tcttggtgca ggccttcctg ctcttcgcag agaacggcaa
    16321 cgcagaccgg ctcaatctca aatcgctgat ctcgttcatt ggcgacgaag atcctgcgct
    16381 cgtcgcagcg ctcgggcgcc tcgacaccaa gctgttcaag gatctggtgc aggacctcca
    16441 ggtgcttctg ctcagctcat cggagctatt ggcctcggac ggagagcgcc tagatgcgga
    16501 gctgctcctc ggcctggggc cccacgcccg ccccggaaag acgcgaatca gcatcatcag
    16561 caccaagttc ctgggcgaca atgctcgggt cctcttctgg gtgtcgcagc ttctgctgac
    16621 gctgacccgc tgggtgaccc gagcgccttc gcctcgcttg caggcggtgg cgatgttcga
    16681 cgaggcggac gtctacctgc cggcgcagtc ccagcccgcc acgaaggggc ccatggagaa
    16741 cctgctgcgc cgcgcgcgct cgggcggcct ggggatcttc ctggccaccc agagccctgg
    16801 ggacctcgac tacaagtgcc gggacaacat ccggagctgg ttcgtcgggc gtgtcgccca
    16861 gaacgtggcg ctggagaaga tgaagccgct cttcgccgag gcccgggtca acgtggcggg
    16921 gaagatcccg gggcaggggg ttggggagtt tcacctgctt caggacggtc gcgtgacgcc
    16981 cttcaaggcg caccaggcgc tccttcgcac cgagcaggtg ccagagcacg agatcttgcg
    17041 gctcgcggcg ctgcgcaggc gcgcccaggc ccgttgagcg caaggtctcg acgagaggac
    17101 atccaggggt gcccgcgggg cacgaccgag cgacacgaga ggtgacgcgt ggacggcgag
    17161 atcatcaatt tcgaggaaga gcaataccgg cacgagcggc tattcgctcg gcaggacgtg
    17221 ctcgatcggc ttcagggctg gctggttggc gagcgggctc tctaccgggg gtgggtgttc
    17281 ctgctcgggg gcccgggggt cggcaagagc gccatccttg cagaactcct gaaggtgctc
    17341 cctgagcaga cgccccggca cttcatccga cgggggaacg aggggtggga tcggcccgag
    17401 gtgatggtgc agaacctctg cgcccagatc gagcggctct tctcggagcc cgtcgatacc
    17461 tccctgccgc tggacgcgcg gctcggggat ttgctccggc gggtatcgag aaagatgctg
    17521 gatccttaca agcagcggct ggtcctcgtg ctcgacggcc tggacgaggc ggtgagcgac
    17581 accgccggga agaaccccct gccgcgcttc ctgccccggg tgctgccgcc cggcgtggtg
    17641 ctgctgtgcg catcgaggcc ggtccacccc gacctggacg ggctcctcca gcacgacaag
    17701 gtgcaaagga tcgatcttga tgacggcgcc tggaccgctt ccaacgaggc ggcatgccgt
    17761 gcgttctggg agcattacgc ggccacgttc gatccgcccc tcgatgcgac cttcgtccgc
    17821 gaggcagtgc ggcgtgccgg tgggaatttg ctgcacgcga tccggctgcg agactggctg
    17881 gaggaccagc cccccgagcg gcggatcgtg aagaacatcc cgaagcagct ttcgggtttc
    17941 ctgtcccaga tctggtccga gctgctcaag ctggacgacg cacgcagcac gctggtcgtg
    18001 accggtctcg gggtcgcctg cgcagcgcgt gaggcgcttc cagcctacct tttccgcgaa
    18061 ctgctcgagt ggtcgtcgag cagcgaggaa gaggatttcc tccgtgtcac gcgccccttc
    18121 cttcgccagg agaacgcgca ctggcatccg gactgcccgg cataccggct gtaccacgag
    18181 tattttcgcg aattcatcgt ctggcagctc ggcgagccgc ggatccggga gctgaaccgg
    18241 ctgctcgcga gcacccttgc tcagtggccc tcgattgcag ggacctcgtc tcaccggggt
    18301 tatgccctcc ggcacgccgt cacccatcgc atcgaaggcg ggatgctgga ggaagcgcgc
    18361 acgctctgca cgaacgtcgt ctacatggag gagaagtgcc gtggcctcgg ggtcgctgca
    18421 gtcgaacggg atctggaagc cgtgattcgc gcctcggggg ctgaagggtc gctggatctg
    18481 gccacggtac tcgctgccct cggcgcggaa gcgagtcggc tccgtgccag cccggcgctc
    18541 ttgcccgcgc tgctctacaa ccgtctgcgc tgcgctggat ggtcgcccga tcgcattggc
    18601 acagtgcttc attttccggc aggactcccg tcgcttcggc tgaggcacgg tgtgcgcttg
    18661 gggccgacgc tgctgcacac gttcgtgggc cacgaaaggc cggtcagcgc ttgcggggtg
    18721 acgccggacg atgggctgct gctttcggca tccgcagatc gcacgctccg tctgtgggcg
    18781 ctcggctcgg gggagcccct cgcggtgctt cgagggcacg aggacgaggt gacatcctgc
    18841 gcgatcactg ccgatgggaa gatggccgtt tcctcctcgg tcgacgcgac cctgcgggtc
    18901 tgggatctca cggcgcagcg ttgcctcgtc tcgctggagc acgaggggcg ctgggtcacc
    18961 gcctgcgccg tgagtccaga cgggaagcgg gtggtcggcg gcctggataa tggccggatc
    19021 acagtgtggg accgggcctc acggaggctc gtcggatcgc ttcaagggca cgcggactac
    19081 gtgaccgctt gccaggtgac agcagacggc aagcgcgtcg tctccgcgtc gcgggatcgc
    19141 acggtgcggg tctgggacat cgcttctggc gcatgcacgc acaccctccg acgtgaagat
    19201 gtggtcggca gcaaggttcc ggccgaacgc gaggaggcgg ggtggatgac ggcgcttctc
    19261 ttgctccacg gtggattgca ggcggtgtcg gtggcgggcg acggcctcgt gatgcgctgg
    19321 gatctcggga cggggcattg cgcacagcgg ttcggtgcgg ggcagggacg cgtggacgct
    19381 tgcgcgcttc tccacgacgg ccgtcacctc gtgtgcggga tggcggatgg gagcatccac
    19441 gtctgggatc tcggcggggg ccgccttctg cgtcgcatgg acgcggccca tgggggcccg
    19501 gtgtccgctc tctcggcgac gcgcgatggg cgtcgtctcg tgtcggcctc gtctgaccgc
    19561 ggcctcaaac tctgggatct gggtggccct gaaggactct ccgcgcgagg gcggcacacc
    19621 gcgcccgtgg ccgcgtgtgc ggtgacgcca gacggaaggt gggccgtttc ggcctccgag
    19681 gatcggacgc tgaaaatctg ggacgtcagg acgggcgctt gccgcgggac gcttccgaag
    19741 cacgaggctc tggtaacggc gtgcgccatc tcagcagacg gtcagcgcgt gctttccgga
    19801 gccagcgacg ggagcgtgag gctgttgcgt ctcggtgcca aagacgcaga gcccatcagg
    19861 agccacgaag cgctggtgag cggggctgcg ctccttggcg atgggcgtat cgtcacggca
    19921 tcggcgaacg gtgaaatcgg catcgccgtg cccgcgacgt cagaggctct cgtggccttc
    19981 cgtggtgatt tcggccctgt cgtcggctgt gccatgaccc cggacggggc gcatgcgttg
    20041 acgatctcgc gggaggggcc cccggtgctg tgggaccttt cgacccgtgc cccgaggctc
    20101 gtgctgagcg atgccacggc ggtctttctt tcgtgtgcgc tcagccgcaa cggcgatcgc
    20161 accgtcctgg ggcgtgagga cggcgtggtg gaggtgcgtg atctggtctc gggacaggtt
    20221 ttgcacgagc ttcgcggtca cacatcgcgg gttttcgggt gtgcgatctc cccggatgag
    20281 acacgggtga tatcggcctc cgaggacgag acgctgcgcg tgtggagcct ggagagcggc
    20341 gagtgcttgg ggatggtcca gggaacctcg tggtttcgct gcgtggcggt gggtcagggg
    20401 gtgatctgcg ctggagacca agagggggac ctctggatga ttgcctccga aaaacaggag
    20461 tcattcctgc ttccccccaa gccgccaatc cctccggcgc agccgaatcc tcccgggccg
    20521 gagatgcctc atccaccgaa acgtctgaat cagccgatcg aatcgggggc gacggccacc
    20581 ggcatcatgg ttcctccccc agagcctccg aggcagccgc cttcttccga cccgtggaat
    20641 gacagcgcga tggtgcttgc gaggctgcgt gatgtgctgg cgaagatcta cgacagcgag
    20701 gtgagcgctc ggcgcctcgt catggatgtc gggctcgacg agcggcgcat cctgttcatc
    20761 ggaacgcttc aggacatctg gcacgccatt cttcgggagg cagtgaagac cgaccgagtt
    20821 gctctgctca tggaatgggt attgggagaa taccccgaga atccggcact catcgacttc
    20881 aagcgtcggt tctttagtca cgggcgcgtc tgatctcatt cgtttcatat caacctggtc
    20941 gatacaggag gctttgagcc atgaacgctg aacctcgatg gcgcgacagc gcatcccgcg
    21001 ccgcctggcg caacgccctc gcccgcaaat accccaccac cgacgaagcc cgtgtcttca
    21061 tcgaccacgt cggcctctcc ccgatacgca ttgcattcag caatcgcgcc gacctcacct
    21121 ggttcgccat cctcgaagaa gcccagcgcc agggcccccg ctgggtcctc gccgtcctcg
    21181 accgcgccct cgaagacttc cctgacgacg acgccctccg ccgcctccgc gatggcgagc
    21241 cggttcgcta tgccgaaggc cctgacgcca acgccctcgg ctggcgcggc cgaggtggcc
    21301 agaccctcga gaagatcctg ggcaaagtca gcaccctcgt ccccgtcagc ttcctcgaag
    21361 tcggcatgcg ccgcgcccat gccgtcgtcc gcgtccgctg cgccgacggc tccctcggct
    21421 cgggcttcct cgccacggac gacctcctcg tcaccaacca ccacgtcctc tcgacccgcg
    21481 ccgcggccac cacggcccgc gtccagttca actaccagaa gaccatcgag ggccgcgacg
    21541 ccgagatgga ggagttcctc ctcgatcccg acgccttctt cgccacctcc gcggccgacg
    21601 actgcaccct cgtcaaggtc cagggcaacc cctcctcccg ctggggcgcc atcgacctcc
    21661 agccggcgcc catcaccagg gacgaccgcg tcaacatcat ccagcacccc ggcggcgacc
    21721 agaaacagct ctccttcttt cacaatctcg tcgtctatgc cggtgagggc cgccttcaat
    21781 acctcaccga caccctcccg ggctcctccg gctctcccgt attcgacaga gaatggcgcc
    21841 tcgtcgccat tcaccacagc ggcggctggg tcgtcgaacc gggcaccaga gagcagttct
    21901 atcgcaacga gggcatcctc gcggagcgca tcctcgccct cctccatacc gcccgcgagc
    21961 cttcggcctg cggcgtgacc acctgaacca tcgacctcac tccctgacgt caaccctcac
    22021 cccacgctca cgctcacgct cacgctcacg cgctctttcg ttctctctcg acacacatcc
    22081 tgactccaac cgaggaacac catggcaaca gccacacgtt tcattcatac cgctgactgg
    22141 cagctcggcc tgcgcgccca tttcattcac ggagatgccg gcgccctcgt ccgggaagcc
    22201 cggctccgca ccgtcgcccg cattggcgcc ctcgcgcgcg aatacaaagc agatttcgtc
    22261 gtcgtcgccg gcgacgtctt cgagcaccac gaactcaaac ccgacaccct gcgccgtgca
    22321 ttcgaccgca tggcggacat ccccacccct gtgtatctcc tccctggcaa ccacgacccc
    22381 ctcatgcccg gctccctcta cgagtcggac cgctggcgga aggagtgccc gcccaatgtc
    22441 catgtcctcg cctcgcgcga ccccatcgtc gtcagcgaag gcgtggtcat tctcccttgc
    22501 c
//
