LOCUS       NZ_CP012159            21116 bp    DNA     circular CON 02-MAY-2024
DEFINITION  Chondromyces crocatus strain Cm c5 chromosome, complete genome.
ACCESSION   NZ_CP012159
VERSION     NZ_CP012159.1
KEYWORDS    RefSeq.
SOURCE      Chondromyces crocatus
  ORGANISM  Chondromyces crocatus
            Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
            Chondromyces.
REFERENCE   1  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals
            a high potential for natural compound synthesis and the genetic
            basis for the loss of fruiting body formation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-2015) Department of Microbial Natural Products
            (MINS), Helmholtz Institute for Pharmaceutical Research Saarland
            (HIPS), Campus E 8.1, Saarbruecken, Saarland 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Newbler v. 2.6, HGAP SMRTPortal v. 2.2.0
            Assembly Name                     :: Cm_c5_Newbler_HGAP3_v13
            Genome Coverage                   :: 366x
            Sequencing Technology             :: Illumina, PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001189295.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 07:18:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,172
            Genes (coding)                    :: 8,124
            CDSs (with protein)               :: 8,124
            Genes (RNA)                       :: 108
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 4 of 48
            Pseudo Genes (incomplete)         :: 44 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 2 of 48
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5445275
            Orig. end                         :: 5466391
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012159.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21116
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="17"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21116
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21116
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11116](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11116)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    391..403
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    876..890
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     misc_feature    complement(948..963)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.93"
                     /tool="antismash"
     misc_feature    1414..1429
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: strong, score: 27.18"
                     /tool="antismash"
     misc_feature    complement(1415..1428)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.07"
                     /tool="antismash"
     misc_feature    1473..1487
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    1575..1588
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.82"
                     /tool="antismash"
     misc_feature    complement(2151..2162)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.62"
                     /tool="antismash"
     misc_feature    2330..2345
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.03"
                     /tool="antismash"
     gene            complement(2356..2985)
                     /locus_tag="CMC5_RS20025"
                     /old_locus_tag="CMC5_040720"
     CDS             complement(2356..2985)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040720"
                     /product="hypothetical protein"
                     /protein_id="WP_050431919.1"
                     /transl_table=11
                     /translation="MQTSLPHGAAAPSAGPPWPYPEPEPRVLPRSRDHALGWGFLFGGA
                     LLTLVAAYLVVAFDALRSIDLLVVFVTPGVGAFAVSLIGVFTLLKNARRKRRDEEVAHT
                     GIRCWGRIVQAAPIQGRGHARSYLDVYLVVEAFAAHEARPTQGPRPYAAGTRVAAQVAF
                     EQHVSLVQMGMLQPGYFCALVLHPSDHGRLLLDGFATPQGAFARLA"
     gene            3050..3553
                     /locus_tag="CMC5_RS20030"
                     /old_locus_tag="CMC5_040730"
     CDS             3050..3553
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040730"
                     /product="hypothetical protein"
                     /protein_id="WP_050431920.1"
                     /transl_table=11
                     /translation="MSGTSGSIGVAMATDVFFTSRLTGHQLWRIRVRDTHAQVMTCKVL
                     QDAARWRGESTHRGGTLETVVQAPPVYGQVTLNPGEHAWIVVRRSRETWHEHPWKGHWP
                     IERVGDEEVVTFIAQRTLSPDFGEVPDRLRPHSRLHPTLRHAVWIPAEPFARYLKMLVK
                     EEAS"
     gene            3550..4380
                     /locus_tag="CMC5_RS20035"
                     /old_locus_tag="CMC5_040740"
     CDS             3550..4380
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF044424.1"
                     /locus_tag="CMC5_RS20035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040740"
                     /product="hypothetical protein"
                     /protein_id="WP_050431921.1"
                     /transl_table=11
                     /translation="MTASADAVSSEAVLRAPRVLEPSRGLLEALTRCAAVRKELRELDG
                     MRNSENAEEEVPLFGARSREPVVDLAALVLLEREMGCVLQDDLLVLLAVRDPVARTFTG
                     LHDLASVGDAEDAGAYESETHACIAMAYSDPIAEMVDGAHGGAYVHLWVPRGSAPSATV
                     VVSTGDPSEGTEMTVGEYLMQRLDEAVSAGWLGAYGEKRVALLRTPARLQGSAPAPVLQ
                     GKRMRVRHARFGEGTVVETNHDGEEVKAVVAFADGQRTLMMRFLTVQEADEAPV"
     gene            complement(4417..5190)
                     /locus_tag="CMC5_RS20040"
                     /old_locus_tag="CMC5_040750"
     CDS             complement(4417..5190)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040750"
                     /product="hypothetical protein"
                     /protein_id="WP_156338739.1"
                     /transl_table=11
                     /translation="MQSPLASCPRCAAPLTAAGWSCAQCGQPLQQQAPGNAGHAVPSGA
                     SPHDTPSHAHPGAATPAAGPPWPYPESNQRVLHDPNGQLLGTILLFTGAVFALMAIGFV
                     LFVGGGKDDRALFMVLPLVVAPALLCLGGGALMMRAAARHKRIAEEVAASGIRCWGRIL
                     QATPIQSDRRTRMRVQLQLEAFAAHDPRGMQDTSRYAPGARVALPVSIEQSVSLVQMGM
                     LQPGYFCALLLHPTDPGKYLIDGFANPQGAFAWLA"
     gene            complement(5265..5984)
                     /locus_tag="CMC5_RS20045"
                     /old_locus_tag="CMC5_040760"
     CDS             complement(5265..5984)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040760"
                     /product="hypothetical protein"
                     /protein_id="WP_050431923.1"
                     /transl_table=11
                     /translation="MASDRFCAKCGQRLRVLSAAARSDEASDEESPSSEPSPISTDEEA
                     PRAGPTWPYPEITQPRWASPKPTMTYVYIGSAVAFSLLFVLSPSQSGAFAPGVIALMSW
                     AMTGYALNNAAHRKRVARELSTSGIRCWGRILQVGPAPWSTGTAIGQPVYRQTHTRVRL
                     QVDAYAAPDPQRPRKRRKKGPRLIAELSIEEYISLAQMGMVQPGNFCALLLHPTDHSQV
                     VLDGLATSKGDFVPLAW"
     misc_feature    complement(5950..5966)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            complement(6125..7951)
                     /locus_tag="CMC5_RS20050"
                     /old_locus_tag="CMC5_040770"
     CDS             complement(6125..7951)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.4"
                     /locus_tag="CMC5_RS20050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040770"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_050431924.1"
                     /transl_table=11
                     /translation="MPLLPDADADRRAYDAARSAVLAGAEDPDVRFAGDPFSLSAWLRV
                     RKLIEAVGDTARVLHHVGLDPARWADLERRWIGLLHQPSVRARHDLWSERLDVRTEAAQ
                     LLSSPGPVSRDALEPGATILTAPDSPTSASAPRRAWWALGYALRGAAPPALRAVDLATG
                     QVVWEGLTSLCTWHSPPARGSYAARGRALFFAHETRIGLADLATGTLHWAASLPAPIAH
                     DDEGRVALFDPLPEPPHATRGGPPSAANSAGVVLVRTQTPALIALDRESGNVRWQIPLG
                     SSARLHEVTGLGVLVHARDVTGQWVSLLDPWTGAARWTIGGRLADATPQVEAVTVRGRH
                     ALLLLTEGTSTPPWPPLGPGVFPGGAPLPGGAQPPQPPVGSGTFSGSPALPQPPARADR
                     SVLRIDVLTGQPIGPPVRADVQARPAPATLERHHVWAGAAAGTLVRITDRPPPGLVDRL
                     LGRRVDDTTTIALPEPDLLVDALEPAGALVLALVHARGERRVRLLALDPSIGALRWDTR
                     DLGPTPDSPAGAALRIHGTLAAVATGTTPDGPTQITGIDAERGVPRWSLAITGWTGHDL
                     LGDALIVWSREHAQIVRIADGTALGFWPLVER"
     gene            complement(8008..9003)
                     /gene="mvaD"
                     /locus_tag="CMC5_RS20055"
                     /old_locus_tag="CMC5_040780"
     CDS             complement(8008..9003)
                     /EC_number="4.1.1.33"
                     /GO_function="GO:0004163 - diphosphomevalonate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /gene="mvaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020737027.1"
                     /locus_tag="CMC5_RS20055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040780"
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="WP_050431925.1"
                     /transl_table=11
                     /translation="MSITGKATAVAHPNIALAKYWGKRPFGHNLPAVPSLSVTLAGLAT
                     RTTVAFDDALAEDELHLGGHPAAAGPTRRVSGLLDRVRAASGRTERARVTSDNDFPTAA
                     GLASSASAFAALALAASTAAGLSTSPEGISDLARRTSVSAARSAFGGFVALRSGAPGDE
                     TLPATPVAPADHWPLRVIIAVTAEGPKDVGSSEGMKLTVDTSPYYAAWVTDAPSLEERV
                     RAAVLARDFQALGSAAEASALRMHASAIAAAPGLLYWTGATVNVLSEVRRLRARGIPAF
                     FTIDAGPHVKVFTVPEAEDEVTTALAAVPGVLRTLSATPGPGAHVVDPAV"
     gene            complement(9000..10004)
                     /gene="mvk"
                     /locus_tag="CMC5_RS20060"
                     /old_locus_tag="CMC5_040790"
     CDS             complement(9000..10004)
                     /EC_number="2.7.1.36"
                     /GO_function="GO:0004496 - mevalonate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016126 - sterol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /gene="mvk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012236838.1"
                     /locus_tag="CMC5_RS20060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040790"
                     /product="mevalonate kinase"
                     /protein_id="WP_050431926.1"
                     /transl_table=11
                     /translation="MSPARGAACGKVILLGEHAVVHGTPAIASGIEHGAEATAEPSTDG
                     RSTLLLGAAEHIAGDTGGDLCRAFGALLAELPGTPPLRVTAESRLLPGGGLGSSAALAV
                     SIARAVRAFDGGVHAIDDARILAAASAWERVFHGNPSGIDTTAAALGGCFLYTRAEGAS
                     PLALRRDVWLAIGSTGTSGSTRLMVESVARLFERKPDVKDQTLPAITALVRNAALALEA
                     GDLQGLGRLMVLNQMLLAGLLVSTEDLERMCNLARDAGALGAKLTGAGGGGSMIALLDA
                     HDEDQAERAAARVLGAWRSAGYDGLLARISAQPRPASTGQPSPAAPPVTEDPE"
     gene            complement(10001..11116)
                     /locus_tag="CMC5_RS20065"
                     /old_locus_tag="CMC5_040800"
     CDS             complement(10001..11116)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012236837.1"
                     /locus_tag="CMC5_RS20065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040800"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_050431927.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.6e-42, bitscore:
                     143.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEHAAAATTEPTSGADRTLEGAHGAAARAFLDFLASIRPAVETR
                     LEARWQREIDRIKGYGPEIEAMAAEARSLTLRGGKRYRAGLVVAAHLGVAPEAPLDAAY
                     DTAAALELIQTYLLIQDDWIDEDDTRRGGPSVHAALGRSLKNERLGAVSALLASDLTWS
                     LAVGLLAAAPADPSLVLATLRTFCETHQDVVVGQHLDVLGRAEDVEQMHALKTGSYTVR
                     GPLLLGATLAGASGDVLAALERYAAPVGVAFQLRDDLLGTFGSEAETGKPVGNDLRNGK
                     RTAVIAWIDGRLDASGQSILDRAFGKSEATPDEVAEATALLVTAGARTAVEDRLDALCT
                     EAERLAAELPVSARAREILAGAAAALRWRQR"
     gene            11912..13198
                     /locus_tag="CMC5_RS20075"
                     /old_locus_tag="CMC5_040810"
     CDS             11912..13198
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040810"
                     /product="hypothetical protein"
                     /protein_id="WP_050431929.1"
                     /transl_table=11
                     /translation="MQLPPRTASSQVHLAHATHFDATEAAWRTAEILAPEQRDLLQEAG
                     APLRAQASALSARVAARVQAEAATRQARARFRARDHVLGQRLMACSDGYLNGPAQRSRD
                     DAVYRAVMLGRSASSIKKARPREEPELVLRVRAQLAVAPDFLGKAHLLADLDVAVTRSL
                     DARAALDAALTAERLAADAEVAARSDLRHGLEQAYGRLRTAFPGQRDFVESFFVRRSRK
                     TPSSERAKVGPPGGDEGGGKGNRERTPDAPGGAASESGAEAPQGAADEHISGVAADAAR
                     ERGTVSAMHLRSRRSRGTMRSLARSRRGRHPRGERSLPRLKCGHHLRNARSLPRLRVLS
                     LPDGRALASSIEARCQVDVLAAPCALYERLVDFEPANHLCGPVGLFPPTLRLLGSCSAW
                     KAGPSDLPWRARPLFSMERRRRQVLIDRG"
     misc_feature    13275..13289
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    13360..13370
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    13531..13543
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.06"
                     /tool="antismash"
     gene            13531..15573
                     /locus_tag="CMC5_RS20085"
                     /old_locus_tag="CMC5_040820"
     CDS             13531..15573
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040820"
                     /product="hypothetical protein"
                     /protein_id="WP_156338740.1"
                     /transl_table=11
                     /translation="MRIAMCLGLLALASCAGDPSGAVARGNGDSEGPDGEAPSEPGGLT
                     GGGGDEDPGVGVTVHLQRAVEGGSVLSFGLPLPKAAVQDAAGMQVLVASAPVAATIRET
                     LAYHDASGSRTGTRAVVVQLPASLMSADGLDVEVRWTGGAGSSAGEPLPFASDEVSAVA
                     TATARTTTRTIVQQGGSYALSEGPVAQKPLFTAREPRVLATFPEGYLARTGILGPQVRA
                     ADAQPGLAFFSSALDGFASSAMYRESYALNPDADSVVDPIADFSAWLYDRCATFLTAHT
                     HLGDVETLRHGFQNCSYYAGKIELSGANRGIFTGKPTADTKYSHLRGLYAYYALTGDES
                     ALEAGKAIADMWYADPLFVVPYRDGHVRGRDKLWTERLLGTSMEGLLYGHQLTGDLKYK
                     EALGEMVDTAHRHITGDAGALAEVNPGMTFPPQNCFIHSGEQHADAMAGDPWCSPWMSA
                     MIIDPLLGWEEQTGDTRVAEIFVRLSRFLRDVGTSYFTNDLLNDSFLSPSVCDNPGAGD
                     NRRRLVPLYGAGIRSNGGRATFGEWDDWQHCADATAITAAGLRALKQAEIYDEGAIGPF
                     ASEGEALLALHHELVACAERGFAEATRTRRDPANWTSAELAAGAGNPTAFITQNRIGYP
                     LHVNNPQRRFSWWFNYAMLQQKLLAEAGIEIGEITPGAVQPAGCP"
     gene            15800..>16381
                     /locus_tag="CMC5_RS20090"
                     /old_locus_tag="CMC5_040830"
                     /pseudo=""
     CDS             15800..>16381
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006976726.1"
                     /locus_tag="CMC5_RS20090"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040830"
                     /product="GTPase domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPFVNYPLREISCKIVYYGPGLCGKTTNLKYVHAHADRATRGNLF
                     TLDTAAERLHYFDYLPLDLGAVWGFKVRMQLYTVPGQLLYNATRRLILGGVDGLVFVAD
                     AQRVRFDANVLSLDNLRDNLSAQGDSLQEVPHVFQYNKRDLPDVAALEDLRAALNLHGA
                     ADFEASARDGSGVFEPLKAIARKVVTKLLRT"
     misc_feature    complement(16830..16846)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.73"
                     /tool="antismash"
     misc_feature    16833..16849
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    complement(17063..17077)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.27"
                     /tool="antismash"
     gene            17104..17358
                     /locus_tag="CMC5_RS20095"
                     /old_locus_tag="CMC5_040840"
     CDS             17104..17358
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CMC5_RS20095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CMC5_040840"
                     /product="hypothetical protein"
                     /protein_id="WP_050431932.1"
                     /transl_table=11
                     /translation="MAFSSIFAMGCGGNACDDAADKAEECGLTSSGGSGDSGDVECTGT
                     VECAANCIVDAPCDAFDGSNADASTAYLECVTGCSGSGS"
     misc_feature    complement(17432..17447)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.79"
                     /tool="antismash"
     gene            17587..19185
                     /locus_tag="CMC5_RS20100"
                     /old_locus_tag="CMC5_040850"
     CDS             17587..19185
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="CMC5_RS20100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_040850"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_050431933.1"
                     /sec_met_domain="Pkinase (E-value: 8.2e-52, bitscore:
                     175.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATCPRCRKRYPDEKTICEADGEVLLPDEAFHGLDVELLPGRMVG
                     EYRIEGKIGEGGFGAVYRAVHPLIGKAAAVKILTRSYSASPQMMSRFIAEARAVNQIRH
                     RNIIDIFSFGALEDGRQFFVMELLDGMPLDRYLKQKGWLSPEEAIAILRGVARALDAAH
                     AAGIVHRDLKPENVFLLFEEDGSIFPKLLDFGIAKLLGDGEAGVKTRTGQPMGTPYYMS
                     PEQCRGKPVDHRTDIYSFGILVHEMLTGHVPFSGDSVMDVMLKQTAEPPPAASSVRSEL
                     STLLDAPILAMLCKAPDDRPESVGLAVESLARAAQEAGYDVQAQPVARVSRKSGGSGGG
                     GVASGMTPAELKAISGADTLVDPRSSGRTPLDAVADVEVSGRRRTAVVVAVVSLVTGLA
                     GATFVASLDSTPTGALQAAMHLPPPPRVEVPAKEAPPEPSVVAEQADVSLSIQSSPRLV
                     DVYVGTKKLGTSAQPLSLPRSKSPIKLTLKATGFVSKDVEIVPSANVVLPVTLTSVPAK
                     KSPSQVVPGRGEVEW"
     misc_feature    17609..17620
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.39"
                     /tool="antismash"
     misc_feature    19656..19672
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    complement(20683..20701)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.04"
                     /tool="antismash"
     misc_feature    complement(20718..20732)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
ORIGIN
        1 ttggcttctg aattgttgat gtattggaat gggatcactc caatcccaag tggtagcacg
       61 ctggtgactg tgagagagcg tgagtaaagt ccgatctcgg agtcgctggc gatgtagatg
      121 tcattaggcg aaataacctc cacgctccaa gggatcggag gcgtggacgt ctccggaact
      181 acgtctcccg atgccagatc gaggcgcagg acccggttgc tggaccgatc cgtgacgtag
      241 attgctgtat gctcttcgtc ggcccagctc atgaaacccg gcgcagcacc aatggaatac
      301 actggagggg gggctgggag cgggaagctg gcatagtcgg ataggctcac gatgcgtatg
      361 tcgcccgcgc cgtcgatgat gtatgcgcgg aggacgctgt cacgcgtctc gagcagcagc
      421 ccgatgcctc ctgagagtcc cgacaccagc tcctcctgga tgccttggga aggatcgcac
      481 cgccagacgg acgtcttgtc caccacgtaa acgaagctcc cctcgactgt gagttgctga
      541 ggctcgtcga gcggatcgac attgacgtaa atgggcgaca gtgtgtactg ggggtatgga
      601 ccacccacga gacgagtgaa ccgggcgaca tagccgccgc ttggtgacac gccggaaatg
      661 tagatgtccg actcgtactc agaaacgacg atgtcgcgtg gatcgtcata gttggggctg
      721 acccggattg ggtttgctcc gaacagtagc gtggcccagt cgatccgaac gactccactg
      781 ctcgagtata cgcggacctt ggcgtagttg aaggcattga tagtaccgat ggtagtggga
      841 attctcacga catagaacgt gtcctttacg acaccattgt cggtgtcgat ggtgacgatg
      901 ttgttgttgg taatcgagga ccagttcacg ctgagcatct ggtcgcttgt gatcgcgctc
      961 agagcgttga catcggtcag cttggcgacc cgagcattgt tcattccctt gaactggaaa
     1021 cccggctggc gttgaatgtc gacggcgcca tggctgttca ggttcaccga gccacttgtg
     1081 aacgtgatgc cgaatccctc cgcgaccagc gtggaagggt gaaggggaag tcgatagact
     1141 tcgccagaag agccattgct cctgacgtaa taaagaaaat tcgactcctt ggtgtaatga
     1201 gttccgcgga cgccagtgag gtcaggtagc ttcgttgtgt aaggcattgg tggatactcc
     1261 tccggatgcg tgggtcgttg ggggttgaat tgagcagaac atcgtttcgt acgcagagcg
     1321 ggcgcggtgc tctgacgtca agctagtggc aagacttggc gattgtttcg gctgcatgcc
     1381 attgcggcat gaatgcatgg aagtggtgca aaatcgaatt cgtgttcgag cgatttggag
     1441 ttggtcctct ctacgaaaac caaagtgtcg atatcagcag tgtcgaaact accgaaaacg
     1501 agtaggctgg gaaccgcttc gagcgatttg gggatgagag tcgactgtct agaatgcgag
     1561 cggctgcgtg cccgtatgat tcttatggcg tgattctcgg ctcgcccctg tctgtgtatg
     1621 agccgaccgt ttcgatggta tgagagttcg tcagcgcgtc ggcttggagg ctccgaggta
     1681 cacgctagct tcacccgcgt gcggtaggct gattcggcct cttgcaggaa atgctgtgcc
     1741 agatgctctg cgccatcgct ctcgagcccc gcacgaactt ccttataagg tgtctcccct
     1801 taccagatca acccgcatgg agcactggta ggacattttg cgtcaatgct atcggcgcat
     1861 gatcgcatcg tggcatgctc gcgagcgcgc ccgaacgaac agcggggatt gccgaggaga
     1921 aaccgatgcc ttgaaccgca tcattgtgag gatacgggga tgacctcgga ctggaaccgt
     1981 tatcagctct gatcgtcttt gggggcgatg acatccggcg attcagatgc aggtagacgc
     2041 atcccaaggc gggaatgggg cactccgcag tcgcgtctgc gagcgtaacc gccgcgtggg
     2101 cgcatgagcc cccggtggac gattccctcc gggcctcact ggcggtgcgc gaaagcgttt
     2161 gcatgagcgc cgaggaagtg ctcccaccag agttcggggc acccttctcc tggcccgctt
     2221 ccacggacac caccttgctc tgggcggagt tgcgtgcctg gtcggaggca ccgcactggg
     2281 ggcttgtact ggcgagacct gggactcggc gtgtcgactc ctcgcgtagt cgaatacgtg
     2341 ctcgaactcg acccctcaag cgagccgggc gaaggctcct tgcggcgtgg caaagccgtc
     2401 gagcaggagc ctcccgtgat cgctcgggtg gagcaccagc gcgcagaagt agcctggttg
     2461 cagcatcccc atctgcacca gcgagacgtg ctgctcgaag gccacctgcg cggccacccg
     2521 ggtcccagca gcgtacgggc gaggcccctg cgtgggccgc gcctcgtgtg cagcgaaggc
     2581 ttcgaccacg aggtacacgt ccaggtagct gcgcgcgtgg ccacggccct ggatcggagc
     2641 ggcctgcacg atcctccccc agcaacggat cccggtgtgc gcgacctctt catcgcggcg
     2701 cttgcgacgg gcgttcttga gcagggtgaa gacgccgatg aggctcaccg cgaacgcgcc
     2761 caccccgggc gtgacgaaca ccaccaggag gtcgatcgaa cggagggcgt cgaacgccac
     2821 cacgaggtag gccgcgacca gggtgagcag cgcgccgccg aagaggaagc cccagccgag
     2881 ggcgtggtca cggcttcgag gcagcacgcg cggctcgggt tccggatagg gccagggagg
     2941 gccagcgctc ggggccgcgg caccgtgagg aagcgatgtt tgcatcgagg tcgggcagtc
     3001 taggcgctcg cctcgacgtc gcaacgagcc gcgaacccag gctgatgtcg tgagcggcac
     3061 ttcgggtagc atcggcgtgg ccatggcgac cgatgtgttc ttcaccagcc gactcaccgg
     3121 gcatcagctc tggcgcatcc gggtgcgtga tacgcacgcc caggtgatga cgtgcaaggt
     3181 gctccaggat gctgcccgct ggcgtgggga gtcgacgcac cgggggggca ccctggagac
     3241 ggtggtgcag gccccacccg tctatggcca ggtgaccttg aatcccggcg aacacgcctg
     3301 gatcgtggtg agacgctctc gcgagacgtg gcacgagcat ccctggaaag ggcactggcc
     3361 gatcgagcgg gttggggacg aggaggtcgt gacgttcatc gcgcaacgaa ccctctcgcc
     3421 cgacttcggt gaggtgcctg atcgcttgcg gccccacagc cgcctgcacc cgaccctccg
     3481 tcatgctgta tggatacctg ccgagccgtt cgctcggtat ctgaagatgc tcgtgaagga
     3541 ggaggcgtca tgacggccag cgcggatgca gtttccagcg aggccgtgct gcgcgcgcct
     3601 cgtgttctcg aaccttcgcg ggggctgctc gaagcactca cgcggtgcgc ggccgtccgg
     3661 aaggagctgc gcgagctcga tgggatgcgg aactccgaga acgccgagga ggaggtgccg
     3721 ctgttcggtg cgcggagtcg tgagccggtg gtggatctcg ccgcgctggt cctgctggag
     3781 cgcgagatgg gttgtgtgct ccaggacgat ctgctcgtgc tcctggcggt ccgtgatccg
     3841 gtggcgcgga cgttcaccgg gctgcacgac ctcgcctcgg taggggatgc cgaggacgct
     3901 ggcgcgtacg agtcggagac ccatgcgtgc attgccatgg cgtactcgga tccgatcgcg
     3961 gagatggtcg atggggcgca tggaggggct tacgtccatc tctgggtgcc gcgtgggagt
     4021 gcgccctcgg cgacggtggt cgtctcgacg ggcgacccga gcgagggcac ggagatgacg
     4081 gtgggggagt acttgatgca gcggctcgac gaggcggtgt cggcgggctg gctgggcgcg
     4141 tatggcgaga agcgcgtcgc gctcttgcgg acgccggcga ggttgcaagg gagcgccccg
     4201 gcgcctgtgc tgcaagggaa acggatgcgc gtccgtcacg ccaggttcgg ggaggggacc
     4261 gtcgtggaga cgaaccacga tggggaagag gtcaaggcgg tcgtcgcgtt cgcggacggc
     4321 cagcgcacgc tgatgatgcg ctttctgacg gtgcaggagg ccgacgaggc gccggtgtga
     4381 cgtcggcctc gccggtgtga cggaggacgg tggggttcag gcgagccagg cgaaggcgcc
     4441 ctgcgggttg gcgaagccgt cgatcaggta cttccccggg tcggtcgggt ggagcagcag
     4501 cgcgcagaag tagcctggtt gcagcatccc catctgcacc aatgagacgg actgctcgat
     4561 ggacacgggc agggcgaccc gggcgccggg ggcgtaccgg gaggtgtcct gcatgccgcg
     4621 cgggtcgtgg gcagcgaaag cttcgagctg gagctggacc cgcatgcgcg tgcgacgatc
     4681 actctggatc ggggtggcct gcaggatgcg cccccagcac cggatgccag aggccgcgac
     4741 ctcttcggcg atgcgcttgt ggcgtgctgc ggcgcgcatc atgagcgccc ctcccccgag
     4801 gcagaggagc gcgggggcga cgaccagggg gagcaccatg aacagggcgc gatcgtcctt
     4861 gccacccccg acgaacagca cgaacccgat ggccatcagc gcgaagaccg cgccggtgaa
     4921 gaggaggatc gtaccgagga gctggccgtt cgggtcgtgg agcacccgct ggttggattc
     4981 cgggtaaggc cagggcgggc cagcggctgg cgtcgcggct ccagggtggg cgtgggacgg
     5041 cgtgtcgtgg ggcgaggcgc cggaaggcac ggcgtggcct gcgttccctg gcgcttgctg
     5101 ctggagaggc tggccacact gggcgcagga ccaacccgca gcggtcagcg gcgcggcgca
     5161 tcgggggcat gaggcgaggg gggactgcat cgctggccga gtctagtcac acgcggagca
     5221 cgtcacccag ggcagagatt ggaagagcgt ggttcctgtt cgggtcacca cgcgagcgga
     5281 acgaagtcgc ccttggaggt ggcgagaccg tcgagcacca cctgactgtg gtcggtcgga
     5341 tggagcagca gcgcgcagaa gttcccgggt tgcaccatcc ccatctgcgc cagggagatg
     5401 tactcctcga tggagagctc cgcgatcagg cgggggccct tcttgcgccg cttccggggt
     5461 cgctgtggat cgggggcagc gtaagcgtcg acctggagcc ggacccgcgt gtgcgtctgg
     5521 cggtagaccg gctgtccgat ggccgtcccg gtgctccacg gggctgggcc gacctgcagg
     5581 atgcgtcccc agcagcggat gcccgaggtc gagagttctc tggcgacgcg cttccggtgt
     5641 gcggcgttgt tcagcgcgta gccagtcatc gcccaggaca tgagggcgat cacgcctggg
     5701 gcgaacgctc cggactgcga aggcgagagc acgaagagca ggctgaaggc gaccgcgctg
     5761 ccgatgtaga cgtaggtcat ggttggcttg ggagaagccc acctgggctg cgtgatctcc
     5821 gggtagggcc aggtcggccc ggcgcgcggg gcctcttcat ccgtggagat gggagagggc
     5881 tcggaggaag gggactcctc gtccgaggcc tcgtcgctgc gtgccgcagc ggagaggacg
     5941 cgcagccgct gcccgcattt ggcgcagaac cggtccgagg ccattcgtgg agcgtcgcac
     6001 tgcggacagg agatcctggg cgtctgcgtc atggccaggg aatctaaggg atgcggtgtg
     6061 acttgccgag tctcgatcgg cgggtcggga ctcgggagga tcggaagcgc tcagcgtccc
     6121 acgatcagcg ctccacgaga ggccagaacc cgagggctgt gccatccgcg atgcggacga
     6181 tctgcgcatg ctcgcgtgac cagacgatga gggcatctcc cagcaggtca tggccggtcc
     6241 agcccgtgat cgcgagggac cagcgaggca cgccgcgctc cgcgtcgatg cccgtgatct
     6301 gcgtcggccc atcgggcgtc gtgcccgtgg cgactgcggc gagcgtgccg tggatgcgca
     6361 gcgcggcgcc tgcggggctg tccggcgtcg ggccaaggtc tctggtgtcc cagcgcaagg
     6421 cgccgatcga gggatcgagc gcgaggaggc gcacccgccg ttcgccacgg gcgtggacga
     6481 gggcgagcac caaggcgccg gctggttcga gggcgtcgac gagcaggtcg ggctctggga
     6541 gggcgatcgt ggtggtgtcg tcgacgcggc ggcccaggag gcgatcgacg agacctggcg
     6601 gcggtcggtc ggtgatgcgc acgagcgtgc cagcggccgc accggcccac acatggtggc
     6661 gctccagcgt ggcgggggcg gggcgggcct gcacgtcggc gcgcaccgga gggccgatgg
     6721 gctggccggt gagcacgtcg atgcggagca cgctgcggtc ggcgcgagct ggcggttgcg
     6781 ggagcgcggg gctgccagag aaggtaccgg aacccacggg gggctgcggg ggctgggcgc
     6841 ctccagggag cggggcgcct ccagggaaga cgccagggcc cagcggcggc caaggaggcg
     6901 tcgaggtgcc ctctgtgagc agcaggaggg cgtgccggcc acgaacggtg acggcttcga
     6961 cttgcggtgt ggcgtcggcg aggcggccgc cgatcgtcca gcgcgcggcg ccggtccagg
     7021 gatcgagcag ggagacccac tggcccgtca cgtcacgggc atggacgagg acgccgagcc
     7081 ccgtcacctc gtgcaggcgt gcgctgctgc cgagcgggat ctgccagcgc acgttgccgc
     7141 tctcgcgatc gagggcgatg agcgcaggcg tctgggtgcg cacgagcacg acgcccgcac
     7201 tgttcgcggc agaaggggga ccgcctcggg tcgcgtgcgg gggctcgggg agcggatcga
     7261 acagcgcgac ccggccctcg tcgtcgtggg cgatgggagc gggcagcgag gcggcccagt
     7321 gcagcgtgcc cgtcgccagg tcggcgaggc cgatccgggt ctcgtgcgcg aagaacaaag
     7381 cgcggcctcg cgctgcgtag ctgccccgcg cgggcgggga gtgccaggtg cagagggacg
     7441 tgagcccttc ccagaccacc tggccggtcg cgaggtcgac ggcgcgcagg gcgggtggtg
     7501 cggcgccccg caaggcgtac ccgagcgccc accaggcgcg gcgcggcgcg cttgcagaag
     7561 tgggtgagtc cggggccgtg aggatcgtcg cgccaggctc cagcgcgtcg cggctcacgg
     7621 ggcctgggct cgaaaggagc tgcgcggcct cggtgcgcac gtcgaggcgc tcggaccaga
     7681 ggtcgtggcg ggcgcggacc gagggctggt gcaacagccc gatccagcgg cgttcgaggt
     7741 cggcccagcg ggcgggatcg aggccgacgt ggtgcagtac ccgggcggtg tcaccgacgg
     7801 cctcgatcag cttgcgcacc cgcagccagg cggagaggga gaagggatcg ccggcgaagc
     7861 ggacgtcggg atcctccgcg ccggcgagca cggcgctccg ggcggcgtca taggcgcgtc
     7921 gatccgcgtc ggcgtcgggg agcaacggca tgatcgaggt gtactcccgg ggtcggggag
     7981 ggggggcgcg tgcccccgcc gtgagcgtca gacggcgggg tcgacgacgt gcgccccggg
     8041 accgggggtc gcgctcaggg tgcggagcac gccaggcacg gcggcgaggg ccgtggtcac
     8101 ctcgtcctcg gcttcgggca cggtgaagac cttcacgtgg ggtcctgcgt cgatggtgaa
     8161 gaaggccggg atgccgcgcg cccgcaggcg gcggacctcg gagagcacgt tcacggtggc
     8221 gccggtccag tagaggagcc ccggagcggc ggcgatggcg gaggcgtgca tgcgcaaggc
     8281 gctcgcctct gctgcgctgc cgagggcctg gaagtcgcgg gcgaggacgg cggcgcgaac
     8341 gcgctcttcg agggagggag cgtccgtgac ccaggcggca tagtaagggc tcgtgtcgac
     8401 ggtgagcttc atgccttcgc tggagcccac gtccttgggg ccttcggcgg tgacggcgat
     8461 gatcacgcgg aggggccagt ggtcggcggg ggcgacgggc gtggcgggca aggtctcgtc
     8521 tcccggagcg cccgagcgca gcgcgacgaa gccaccgaaa gcagaccggg ctgccgagac
     8581 gctggtgcgg cgcgcgagat cgctgatgcc ttcgggcgag gtggagaggc ccgcggcggt
     8641 gctggcggcg agcgcgagcg cggcgaaggc cgaggcgctc gaagcgagcc cggcggcggt
     8701 ggggaagtcg ttgtcgctgg tgacgcgggc gcgctccgtg cggcccgagg cggcgcggac
     8761 gcgatcgagc agaccgctga cgcggcgggt ggggccggct gcggcagggt gtccgccgag
     8821 gtgcagctcg tcctcggcga gcgcgtcgtc gaaggcgacg gtggtgcgcg tggcgaggcc
     8881 cgccagggtg acggagaggc tggggacggc ggggaggttg tggccgaagg ggcgctttcc
     8941 ccagtacttg gccagcgcga tgttgggatg ggccacggcc gtggccttgc ctgtgatgct
     9001 cattcgggat cctcggtgac ggggggcgca gcgggcgagg gctggcccgt cgatgctggg
     9061 cggggctggg cgctgatgcg ggcgaggagg ccgtcgtacc ccgcgctcct ccacgcgccg
     9121 agcacgcggg cggcggcccg ctcggcctga tcttcgtcgt gggcgtcgag cagggcgatc
     9181 atggagccgc cgccgccagc gccggtgagt tttgcgccga gggcacccgc gtcacgcgcc
     9241 aggttgcaca tgcgctccag gtcctcggtc gagaccagga ggccggcgag gagcatctgg
     9301 ttcaggacca tgaggcgacc gaggccctgg agatcaccgg cttccagcgc gagggctgca
     9361 ttgcgcacca gcgcggtgat cgcggggagg gtctggtcct tgacgtcggg cttgcgctcg
     9421 aacaggcgcg ccaccgactc gaccatgagc cgggtcgacc cgctcgtgcc ggtcgatccg
     9481 atggcgagcc acacgtcgcg acgcagcgcg agggggctcg cgccctcggc gcgggtgtag
     9541 aggaagcagc cgccgagcgc tgcggcggtg gtgtcgatgc cggaggggtt gccgtggaag
     9601 acgcgctccc acgcgcttgc ggcggcgagg atgcgggcgt cgtcgatggc gtgcacgccg
     9661 ccgtcgaacg cgcggacggc gcgggcgatg gagacggcga gcgccgcgga gctgccgagg
     9721 ccgcccccgg ggaggaggcg gctctcggcg gtgacccgca agggaggcgt gccagggagt
     9781 tcggcgagga gggcgccgaa cgcgcggcag agatcaccgc cggtgtcgcc ggcgatgtgc
     9841 tcggcagcgc cgaggagcaa ggtgctgcgc ccgtccgtcg agggctctgc ggtggcctcc
     9901 gcgccgtgct cgatgcccga ggcgatggcc ggggtgccat gcacgacggc gtgctcgccg
     9961 aggaggatga ccttgccgca ggcggcgcct cgggctgggc tcaccgctgc ctccagcgga
    10021 gcgcggccgc ggcacccgcg aggatctctc gagcgcgtgc ggacacgggc agctcggcgg
    10081 cgaggcgctc ggcctcggtg cagagggcgt cgagccgatc ctccacggcg gttcgcgcgc
    10141 ccgcggtgac gagcagcgcc gtcgcttcgg cgacctcgtc gggcgtcgct tcgctcttgc
    10201 cgaacgcgcg gtccaggatc gactgcccgc tggcgtcgag gcgcccgtcg atccaggcga
    10261 tcaccgcggt gcgcttgccg ttgcgcagat cgttgcccac gggcttgcca gtctccgcct
    10321 cgctgccgaa ggtgccgagg agatcgtcgc ggagctggaa cgccacgccc acgggggccg
    10381 cgtaccgctc cagcgcggcg agcacgtcgc ccgaggcccc ggcgagcgtg gctccgagga
    10441 gcaagggacc ccgcacggtg tagctgcccg tcttgagcgc gtgcatctgc tcgacgtctt
    10501 ccgcgcgccc gagcacgtcg aggtgctgtc cgaccaccac gtcctggtgg gtctcgcaga
    10561 acgtgcgcag cgtggcgaga acgagagaag ggtcggcggg agccgccgcg aggaggccga
    10621 ccgcgaggct ccaggtcagg tcactggcga gcagcgcgct cactgcgccg agccgctcgt
    10681 tcttcagaga gcgacccagc gcggcgtgga cgctggggcc gccgcggcgg gtgtcgtcct
    10741 cgtcgatcca gtcgtcctgg atgagcaggt aggtctggat caactccagc gcggcggcgg
    10801 tgtcgtaggc ggcgtcgagc ggagcttccg gcgcgacgcc caggtgcgcg gcgacgacca
    10861 ggcctgcgcg gtagcgcttc ccgccgcgca acgtcaggct ccgcgcctcc gccgccatgg
    10921 cttcgatctc gggaccgtag cctttgatgc ggtcgatctc gcgctgccag cgggcctcga
    10981 ggcgcgtctc cacggcaggc cggatggagg ccaggaagtc gaggaacgca cgcgccgcgg
    11041 cgccgtgtgc gccttcgagc gtgcgatcgg cgccggaggt gggttcggtg gtggctgctg
    11101 ctgcgtgctc tggcatgagg gcgcgggagc ctagcaccgt cactgttcca gataaggcgg
    11161 gatctgttcg tcgttcgcgg gagggagctc gtcgctcggg ggttgccgag agggtccagc
    11221 acacgcaccg cgcgcgtcca gcacggggcc gcgtcagtcc acctcggcct cgccgctgtg
    11281 ccgtgacgtc cagaaagcgc cgacccgaag gcgccgagag gcgccgaccc gaaggcgccg
    11341 agaggcgccg acccgaaggc gccgaccgca tcgacgctcc accagggtcc cagctcggcg
    11401 gaagcggcgc tgaccgcatg cctccgagcg gtcatcccgg aggcgcagtc cgcatcgacg
    11461 ttccaccgaa ccatccaccg tgagggagcc gaccgcatcg acattccacc ggagcgaaca
    11521 cccagaggcc acgctcgcat cgacgtttcg tgccgtcccc gagccgaggg aagcgcccgc
    11581 atcgacgttt cgccccgtcc ctgacccgag ggaaacgccg gcatcgacac ctctccgagc
    11641 gccgatcccg gaggcgccgc cctcatcgcg ccctcgctgt gcgccgcgga gcgccttcat
    11701 cctcggtgtg gacgctcgcc ggcgccttcc cacccacctt gtcccaccaa acacgagcga
    11761 tcgttcccca acccgagaag aaatttacgc gcccctcgtc gaacacgaaa acgcggcgtg
    11821 tctgcgcccg atcctcacct ccgcctggag ccgcttcacg aaggcgaccc cctggctgga
    11881 gaccactctg aacgaccttc cagaggaacc catgcagctc ccccccagga cggcatccag
    11941 ccaggtccac ctcgcgcatg cgacgcactt cgacgccacc gaggcggcgt ggcgcaccgc
    12001 cgagatcctc gccccggagc agcgcgacct cctccaggag gccggagcgc cgctccgggc
    12061 gcaggccagc gcgctctcgg cgcgggtcgc ggccagggtg caggccgagg cggcgacgcg
    12121 tcaggcgcga gcgcggttcc gggcgcggga ccacgtgctc ggccagcggt tgatggcgtg
    12181 cagcgacggc tacctcaacg gcccggcgca gcggagccga gacgatgcgg tctaccgcgc
    12241 ggtgatgctc gggcgctcgg ccagctcgat caagaaggcg cggcctcgcg aagagccgga
    12301 gctcgtcctc cgggtgcgcg cgcagctcgc cgtggcgcca gacttcctgg ggaaggcgca
    12361 cctcctcgcc gatctcgacg tggccgtgac gcggagcctc gacgcccgcg ccgcgctcga
    12421 cgccgccctc acggccgagc gcctcgcggc cgatgcggag gtggcagcgc ggagcgacct
    12481 gcgccacggc ctcgagcaag cgtacggcag gttgcgcacg gcgtttccag ggcagcgcga
    12541 tttcgtggag tcgttcttcg tgcgcaggag caggaagacg ccgtccagcg agcgcgcgaa
    12601 ggtgggtccg cccggtggcg acgaaggggg agggaaaggg aaccgcgagc gcacgccgga
    12661 cgcgccagga ggagcggcga gcgagagcgg ggcggaggca ccccaggggg cagcagacga
    12721 gcacatctcg ggagtcgcgg cagatgcggc gagggagagg ggcaccgtgt cggcaatgca
    12781 cctcaggtct cgtcggtcgc gagggacgat gcgatccttg gctcgatcga ggcgcgggcg
    12841 tcacccgagg ggcgagcgct cgcttcctcg attgaagtgt ggccatcacc tgagaaatgc
    12901 tcgctcgctt cctcgattgc gggtcttgtc tctacccgac ggtcgagcgc tcgcttcctc
    12961 gatcgaggct cgatgtcagg tggatgtgct cgccgcaccc tgcgctcttt atgagcggct
    13021 cgtcgacttc gagccagcca accacttgtg tggacccgtt ggtctgtttc cacccaccct
    13081 ccgcttgctc ggttcctgtt ctgcctggaa agcaggacct tctgaccttc cgtggcgtgc
    13141 tcggcctctg ttctccatgg aaagacggcg tcgccaggtg ctgattgacc gcgggtgaag
    13201 gcgtcgaggc gagggcgagc gcgtgcggga tgggggcccg gagagatacg gcgcagcgac
    13261 atctcgatgc gcagagcaag cccgtcgatt gctgtttctt tcccggttcc gggctgcatt
    13321 ccatgcttcc acggcgtcaa tccaggagat cccgtgggct gccatgccac ctgagcggat
    13381 cacgctggac gtgattcagg gcgacacgta cagtcgggac ctcagctcgt tatcgggcat
    13441 ggccggggat cgttttcggg ccccgcgcac gccgcggtaa tgcaaccgcc gctgaaaaag
    13501 cggcgcgccg attacatcac gagagggtga atgcgcattg caatgtgcct gggtctcctt
    13561 gcgctcgcca gctgcgcggg cgaccccagc ggggcggtgg cgcgagggaa tggcgactcc
    13621 gagggcccgg atggcgaggc gccgtcggag ccgggagggc tcaccggcgg tggcggtgac
    13681 gaagatcctg gggtcggagt gacggttcac ctccagcgcg ccgtggaggg gggctcggtg
    13741 ctgtccttcg gcctgccgtt gccgaaggcg gcggtgcagg acgctgcggg aatgcaggtc
    13801 ctcgtggcga gtgcaccagt ggcggcgacg atccgcgaga cgctggccta ccacgacgcg
    13861 tcggggagcc ggacggggac gcgggcggtg gtggtgcagc tcccggcgtc gctgatgtcg
    13921 gccgacgggc tcgacgtgga ggtgcgctgg acgggaggtg cgggatcctc ggccggagag
    13981 ccgcttccct tcgcctccga cgaggtgagc gcggtggcca cggcgacggc acggacgacc
    14041 acgcggacca tcgtccagca gggcgggtcg tatgccctct cggaggggcc cgtcgcgcag
    14101 aagccgctgt tcaccgcccg cgagccgcgg gtgctggcca ccttcccgga gggctacctg
    14161 gcgcgtacgg gcatcctcgg cccgcaggtc agggccgccg acgcgcagcc ggggctcgcg
    14221 ttcttctcgt cggcgctcga tggcttcgcg agctccgcga tgtaccgcga gagctatgcc
    14281 ctgaacccgg atgccgactc ggtggtggat ccgatcgcgg acttcagcgc ctggctctac
    14341 gatcgctgcg cgacctttct cacggcccac acccacctcg gtgatgtgga gacgctgcgc
    14401 cacggcttcc agaactgcag ctactacgcg ggcaagatcg agctgtccgg cgcgaaccga
    14461 ggcatcttca cgggcaagcc cacggccgac accaagtact ctcacctgag ggggctgtac
    14521 gcgtactacg ccttgaccgg agacgagtcg gccctggagg ctgggaaggc gatcgccgac
    14581 atgtggtacg ccgatccgct cttcgtggtg ccttaccgcg atgggcacgt gcgggggcgc
    14641 gacaagctct ggaccgagcg cctcctcggg acgagcatgg aagggctcct ttatggccat
    14701 caactgaccg gcgacctgaa atacaaggag gcgctcggcg agatggtcga cacggcgcac
    14761 cgccacatca cgggcgacgc gggcgcgctc gccgaggtga accccgggat gaccttccct
    14821 ccgcagaact gcttcatcca ttcgggagag cagcacgcgg acgcgatggc gggggatccg
    14881 tggtgctcgc cctggatgag cgcgatgatc atcgatccgc tgctgggctg ggaggagcag
    14941 accggggaca cgcgtgtggc agagatcttc gtccgcctgt cgcggttcct gcgggacgtg
    15001 ggaacgagct acttcacgaa cgacctgctc aacgactcct tcctttcgcc atcggtctgc
    15061 gacaaccccg gcgctggcga caaccggagg cggctggtgc cgctctacgg ggctgggatc
    15121 cggtcgaacg gtgggcgcgc gacgttcggc gagtgggacg actggcagca ctgcgccgac
    15181 gcgacggcga tcacggccgc cgggctgcgg gcgctgaagc aagcggagat ctacgacgag
    15241 ggggcgatcg gtcccttcgc gagcgaaggc gaggcgctgc tcgcgctcca ccacgagctc
    15301 gtcgcctgcg cagagcgtgg cttcgccgag gcgacacgca cgcggcgcga tcctgcgaac
    15361 tggacgagcg cagagctggc tgcaggggca gggaacccga cggcattcat cacccagaac
    15421 cggatcggat acccgctgca cgtgaacaat ccgcagcgcc gcttcagctg gtggttcaac
    15481 tacgccatgc ttcagcagaa gctgctcgcc gaggcgggga tcgagatcgg ggagatcacg
    15541 cccggcgcag tgcagccggc tggttgcccg tagcgacgga tcctctcgcg caggtgccgt
    15601 gtccgcgcac gtcccgccct ggccactcct ggtgattgcg tgcacggcgc ctcgcccccg
    15661 ttcctgctga ttgcatgagc gtgagcgagg cacgtgctcg ccctggtcgg ctggcgagaa
    15721 tgcgtgcgca ctccattgca cagtggggtg gtgcgacgca tcttgtgggc agaccttcag
    15781 cgtcccgcgg agccagagca tgcccttcgt gaactatccc ctccgggaga tcagctgcaa
    15841 aatcgtctat tatggccccg gtctctgtgg aaagaccacg aacctgaagt acgtgcatgc
    15901 ccacgcggac cgcgcgacgc ggggcaatct gttcaccctc gatacggcgg cggagcggct
    15961 gcactacttc gactatctgc cgctcgatct cggggccgtg tggggcttca aggtccggat
    16021 gcagctctac accgttccag ggcagcttct ctacaacgcc acgaggcggc tcattctcgg
    16081 cggcgtggac ggcctggtct tcgtggccga tgcacagcgc gtgcgcttcg acgccaatgt
    16141 cctgtcgctg gacaacctgc gcgacaacct gtcggcgcag ggggattcat tgcaagaggt
    16201 cccgcacgta tttcaataca acaagcgaga cctgccggac gtggcggcgc tggaagatct
    16261 ccgggctgcg ctcaatctcc atggcgctgc ggatttcgag gcatcagccc gggatgggag
    16321 cggtgtgttc gagccgctga aggcgatcgc gcgcaaggtc gtcaccaagc tgctgaggac
    16381 gggggcgtgt ccgaagatcg atgtgccccc tcccgagtcc gcgtcggtcc ccatcaagtc
    16441 ctggccagcc gccgcgttcc gacgtggtgc gctcggcgga cgccccgccc gtcccatcgc
    16501 gccattgagt gcgcgctgac acctcgtccc ctcggccctt ccctccaccg ttccgttggc
    16561 ccttcgcgag agacgcccgt ccgtcggtcc ttcgcgagag atgcctgtcc gtcggtcctt
    16621 cgcaggagac atcggggtga agtggagacg cctggatgcg gggatcgccc cgcatcccct
    16681 gagggtcgcc ctggcccacc aaggagggcg ctgcgatggc gctgcgggat ggcaggtgca
    16741 gggatgaggc ttccagatgg gtcgggcctc acgtttcgag atggtgtgaa cggccccgta
    16801 tacttttcac cacagcgtgg cgcaaagagc tgtagtgaat ttactacaca ccacaagagt
    16861 tgacggcgcg atcctcatcg ttgtacgtac cgcacgtacg gctcggggtt tgcactaccg
    16921 gccgtaaggc gatgccctcc atctggcggg acaactgaat aggggagaag cggcgaccgt
    16981 ccgaaagcgc gttcgtcgga agcgtggctg gatgtcgctg gtcatgtggc ttcccttggc
    17041 actggtacgt gtaaggagat gaggacaatg aacttcaaga ctgctctttt ggcttctggt
    17101 ctgatggctt tctcgagcat cttcgccatg ggctgcggcg gcaacgcctg tgacgacgct
    17161 gccgacaagg ccgaggagtg cgggctgacc tcttcgggcg gcagcggcga ctccggcgac
    17221 gtggagtgca ccggcaccgt cgagtgtgcg gcgaactgca tcgtcgacgc tccctgcgac
    17281 gcgttcgacg gcagcaacgc ggacgcctcg acggcgtacc tcgagtgcgt caccggctgc
    17341 agcggctcgg gcagctgagc ccctgacgac aggacgggga tgacccgttc gtcgtcggag
    17401 tgaacggccg cgatcggttt cgatcgcggc tgtttacttt tgtacggccc tggtccccgg
    17461 gcgctcacag cgccgtgcgc gtcacgaagg ctttttcttc gagagggctc ggtctggcga
    17521 tccggcgtgc ctcgtgtagt ctggtgcggc tctttcttca ccgaggcgca tgccgtaggt
    17581 ctcttcatgg ctacctgccc ccgctgccgc aagcgttatc cagacgagaa gacgatctgc
    17641 gaggctgacg gcgaggtgct gctcccggac gaagcgttcc acgggctcga cgtcgagctg
    17701 ctccccggca ggatggtcgg ggagtaccgg atcgagggga agatcgggga ggggggcttc
    17761 ggggcggtgt accgcgccgt gcatccgctc atcgggaagg ctgctgccgt caagatcctc
    17821 acccggtcgt actcggcgag tccgcagatg atgtcgcggt tcatcgcgga ggcgcgggcg
    17881 gtcaaccaga ttcgccaccg gaacatcatc gatattttct cgttcggggc cctggaagac
    17941 ggtcgccagt tcttcgtgat ggagctgctc gatgggatgc cgctggatcg gtatctcaag
    18001 cagaaagggt ggctgtcgcc cgaggaggcg atcgcgatcc tgcggggggt cgcgcgggca
    18061 ctggatgccg cccatgcggc agggatcgtt caccgggatc tgaagccgga gaacgtgttc
    18121 ctgctcttcg aggaggatgg gtccatcttc ccgaagctgc tcgacttcgg gatcgccaag
    18181 ctgctcgggg acggggaggc gggcgtgaag acccggacgg ggcagccgat gggcacgccc
    18241 tactacatgt ctcccgagca gtgtcgaggg aagccggtcg atcaccggac ggacatctat
    18301 tcgttcggga tcctcgtgca cgagatgctg acgggacacg tcccgttctc gggcgacagc
    18361 gtgatggatg tcatgctgaa gcagacggcg gagccgccgc cggccgcgtc gagtgtgcgg
    18421 agcgagctgt cgacgctcct ggacgcgccg atcctggcca tgctgtgcaa ggcccccgac
    18481 gatcgcccgg agtcggtggg gctcgcggtg gagtccctgg cgcgcgcggc gcaagaggcg
    18541 ggctacgatg tgcaggcgca gcccgtcgcg cgggtgtcgc gcaagagcgg cgggtcaggg
    18601 ggaggtgggg tcgccagcgg gatgacgcct gccgagctga aagccatctc gggggccgat
    18661 acgctcgtcg atcctcgctc gagtggccgg actccgctcg atgccgtcgc ggatgtcgag
    18721 gtgtccgggc gccgccggac cgcggtggtg gtggccgtgg tgtcgctcgt gaccgggctc
    18781 gccggggcga ccttcgtcgc ctcgctggac tcgacgccga ccggcgcgct ccaggccgcg
    18841 atgcacctgc ctccaccacc tcgcgtggag gtgcccgcga aggaggcccc tccggaaccg
    18901 agcgtggtcg ccgagcaggc ggatgtctcg ctttcgatac agtcgtcgcc acggctggtg
    18961 gatgtctacg tggggacgaa gaagctgggg acgtcggcgc agccactctc gctcccgcgc
    19021 agcaagagcc ccatcaagct gacgctgaag gcgacggggt tcgtcagcaa ggatgtggag
    19081 atcgtcccgt cggccaacgt ggttctgccg gtgacgctga cgtccgttcc agccaagaag
    19141 agtccgagtc aggtggtgcc tggacgtggg gaagtggagt ggtgatgtgg ggaggagcga
    19201 gggacgccac aggatgagca ggaggttgcg gcgcggcgtc tggctcgcag gggtcgtgct
    19261 gaccgtggct gcttgcgtcg agttccctga ccggagccgg gcgatctgtg gcgacggttt
    19321 tctcgacgag ggagaagact gcgatggtca ttcgcgcagc ttcgacggca aggactacga
    19381 gtgtgatctc cgacgttgcc gcctggtctg cgatcccacg gatgtagagg catgccgtga
    19441 ggcggctgcc agccagagcg ccagtacgtc cgaaggggcg cccatgtgct gccccgctgg
    19501 ctggggatgc ggtgtggatg ggatctgtcg ctctgcgcag aaccagtacg ttcgtggagc
    19561 cgccgtggag atcacggtga gccagctggt gacggcagac ttcgatggcg atggcctcca
    19621 ggacatcctc tccgtcagtg actccgagct cgccgtgcac catttcgcag cgggcagcat
    19681 gtctcaggcg ctgcgtctga acgtctccga ccaggtgatc gcggtgggga atgtggtgag
    19741 ggtgggggaa gagggggggg aggatctggt gctggccatc ggcaacggcg tgggcgtgtt
    19801 gcgtggcgat ccggaccatc ggttcacacc ggagatgtac ccggtccctc tccgcttcga
    19861 tcagaagccg ctggggcacc agcaatggaa gatggtgctc gcagaccggg gcatcgctca
    19921 tgacgattcg ctggacgatg tgtccgtcgt gacccccaat gaggtcattc tcctcagggg
    19981 ccacggcagc gaggggggag attcgctggg agggagcctg cacgcgtccc agcttccggg
    20041 cgtcgccgaa ctcaggtggc ccatcgtggc agccaacatc gatcgaagga cgccgtgcga
    20101 ggagctgatc atcccgctga tgtatcaggg gacgccagcc gtttacctgc acagcccctg
    20161 tgatccggat ctgccgtcga ccggctggat gttccagggc gccagcgggt tcgcggggcc
    20221 cgtccaggtg ttctcgatga aggacgatcc agcgcagccc gtggtggcgc tcggtctacg
    20281 gtacggggaa ggagatgacg ccagcacggt gattcgcgtc cttcgccatc agggggagcg
    20341 gttcgaggaa ggtccgtgcg tggtggtgtc ccctcaaggc cagtccacga atgaggacga
    20401 atcctgcgtc aaggaccccg tgccgctggc gatcggggat ctggatggcg attgcattcc
    20461 cgattatgtg gatccgtgcc aggtcgtcat gagcgcgaat tcggcgtcgt cgagcgcgat
    20521 gtgtggcgcg ggcgcgggtc aagggtcggt atgtcatgcc gggatggcgc tcaatccgag
    20581 caatttccgc aacacgcagc ttccctggac gacggcactg atccaggacg tgaatggtga
    20641 tgggaactcg gatgtgctcg ctgtcgcggc gaggagcacg gcgctgtcgt tttatcgagg
    20701 caccgggaag gctcttctga atccgagttc catcccggtg ggggtgcctc tgggacagct
    20761 cgctaccgga gatttcgacg gggatagcat cacggacatc gggatcctgg aggagaccgc
    20821 ggagggggcc gatgcccagg tgctcgtctc cttcgggcag tatctgacca agccaggctc
    20881 gcccatcagg atcgggagcg tgcggggagg gtcgcagctc gtgacgggcg attacaggcc
    20941 cctctcggcc gcgcgtgacg ggatgacgga cctcgctgtg ctgtcggtgc cgtccgaaga
    21001 cacgccgatg ccagggcccc ggagagagga cgccatcctg accctgttcg ccgggaatgc
    21061 cgatcgtctg atgcagtcga cgatcagctt gaccgatgat gtgctgaaga gcggtg
//
