LOCUS       NZ_CP012159            11797 bp    DNA     circular CON 02-MAY-2024
DEFINITION  Chondromyces crocatus strain Cm c5 chromosome, complete genome.
ACCESSION   NZ_CP012159
VERSION     NZ_CP012159.1
KEYWORDS    RefSeq.
SOURCE      Chondromyces crocatus
  ORGANISM  Chondromyces crocatus
            Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
            Chondromyces.
REFERENCE   1  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals
            a high potential for natural compound synthesis and the genetic
            basis for the loss of fruiting body formation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11388132)
  AUTHORS   Zaburannyi,N., Bunk,B., Maier,J., Overmann,J. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-2015) Department of Microbial Natural Products
            (MINS), Helmholtz Institute for Pharmaceutical Research Saarland
            (HIPS), Campus E 8.1, Saarbruecken, Saarland 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Newbler v. 2.6, HGAP SMRTPortal v. 2.2.0
            Assembly Name                     :: Cm_c5_Newbler_HGAP3_v13
            Genome Coverage                   :: 366x
            Sequencing Technology             :: Illumina, PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001189295.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 07:18:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,172
            Genes (coding)                    :: 8,124
            CDSs (with protein)               :: 8,124
            Genes (RNA)                       :: 108
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 4 of 48
            Pseudo Genes (incomplete)         :: 44 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 2 of 48
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3704645
            Orig. end                         :: 3716442
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012159.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11797
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="12"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11797
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11797
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6797](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6797)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1..762
                     /locus_tag="CMC5_RS13860"
                     /old_locus_tag="CMC5_028090"
     CDS             1..762
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020739109.1"
                     /locus_tag="CMC5_RS13860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028090"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_050430862.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.5e-15, bitscore:
                     54.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIIIGAGRGSRLRHLTDEIPKTLVHVLGRPMLDAILEALAAGG
                     FSRKDVVFICGYRKEVIQEAYPDLTYVENRDWERNNILLSLLCAREHLAEGFVSTYADI
                     VYRPAIVADLVRSPHDLTLACDTDWRRRYIGRSEHPETDAEKLRVEGDRVVEISRRIPS
                     ELATGEFIGVMKASAAGAATLTRAFDEAQARFAGREFREGRSFERAYLLDMLQHMLEGG
                     TAIHKVDTHGGYMEIDTLQDAASAERWWRGE"
     gene            complement(773..1240)
                     /locus_tag="CMC5_RS13865"
                     /old_locus_tag="CMC5_028100"
     CDS             complement(773..1240)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010666517.1"
                     /locus_tag="CMC5_RS13865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028100"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_050430863.1"
                     /transl_table=11
                     /translation="MRLTLHTDYALRALLYVGMRPDALVSIRQIAEAYGVSENHMVKVV
                     HRLGQGGFIETLRGRGGGLRLARSPTEIRIGDVIRWTEEDMALVACFQKEPTYGGCILT
                     GACGLQALLGEALEAFMAVLDRATLAELLPTAEQPSPMAARLKLPVLRAPP"
     misc_feature    1319..1329
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            1323..2534
                     /gene="hmpA"
                     /locus_tag="CMC5_RS13870"
                     /old_locus_tag="CMC5_028110"
     CDS             1323..2534
                     /EC_number="1.14.12.17"
                     /GO_function="GO:0008941 - nitric oxide dioxygenase NAD(P)H
                     activity [Evidence IEA]"
                     /GO_function="GO:0019825 - oxygen binding [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0051409 - response to nitrosative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hmpA"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012335291.1"
                     /locus_tag="CMC5_RS13870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028110"
                     /product="NO-inducible flavohemoprotein"
                     /protein_id="WP_050430865.1"
                     /transl_table=11
                     /translation="MSRTLSEHTISVVKATVPALQAHGVTITRRMYERMFKNESIRNLF
                     NQSHHGASGSQPHALAAAVLAYAQNIDNLAVLAPAIERIAQKHAGLNILPEHYPFVAEA
                     LLAAIQDVLGDAATPEVMDAWGAAYWFLAEVLIGREAQIYREAAEARGGWNGWRDFVVT
                     ERVRESDCITSFTLVPADGKPVLEHRPGQYLTFWVDLPGRSPLKRNYSISSAPSDASYR
                     ITVKREPEGTVSGWLHDEVKVGTRLKVAPPAGEFFLPETPARPVVLLSGGVGQTPLLSM
                     LDTLAVQHPEVRTHFVHGALNGALHALGTHVRGVAQQSSGNIAATVFYEKPRNEDRHGV
                     DYDEAGLISLDWLQANTPLGDADYYLCGPRPFLRAFVGGLGKLGVPAAQIHYEFFGPAD
                     ELLA"
     gene            complement(2631..4799)
                     /locus_tag="CMC5_RS13875"
                     /old_locus_tag="CMC5_028120"
     CDS             complement(2631..4799)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015722.4"
                     /locus_tag="CMC5_RS13875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028120"
                     /product="bifunctional serine/threonine-protein
                     kinase/formylglycine-generating enzyme family protein"
                     /protein_id="WP_050430866.1"
                     /sec_met_domain="Pkinase (E-value: 2.1e-29, bitscore:
                     101.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSQRTRDPLGISGTLIAEKYLISHAVGEGGFSVVYKAEHTIWRQ
                     PVALKCFKILANAPADQRDKLLDGFIQEGRLMAELSSRSAAIVQARDIGTFTSPDGQWL
                     PYMVLEWLEGKPLDAVLWEETQGGAPNRSLHEAMALLEPAAVALEQVHARGIAHRDIKP
                     ANIFVIGDPRGIGVHVKVLDFGIAKVMSEHAAAAAALAHTGQDITAFTPNYGAPEQFSR
                     THGATGPWTDVFAMALILVEILTGKSALQGDDYMQLAVESRDPIRRPTTRAFGLDLGST
                     VEAVLLQALAVSPQERFRTMGQFWTALHQAVFPDAGTWSPATSSGLVSSGIPSRSSLPS
                     MPGYAGAGASPPSSLPGSGPAVVGGTRQPENSGSFVPSTSTAVPTKRSAAPVVLGALGA
                     VILAAGGFAALKILGGGSEVTTTADTSPTASVAAGAPSASASAATSAAAPPGCPEGMAL
                     VTGGRFFMGSDEPTFKLWQPAHKVTIDSFCIDINEVTAGEYQACSDVGDCKRPPEAISF
                     PKDPSVSDAEHEKLLKTISEHCTFGKPELTKHPINCVSWDLADAYCKVQKKRLPTEAEW
                     EYAARGSDGRKFPWGNEVGDHTFMNACGTECTEWETARGAKPSQRMYEANDGFPGTAPV
                     GSFPKGKTKFGLNDMVGNVWEWTGDWFAVYKDEEQVNPKGAPAGDRKAIRGGGFNGGFA
                     LWLNPAFRFHQLATASAPGIGFRCAREL"
     misc_feature    4933..4948
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            complement(5001..6797)
                     /locus_tag="CMC5_RS47510"
                     /old_locus_tag="CMC5_028130"
     CDS             complement(5001..6797)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016970.4"
                     /locus_tag="CMC5_RS47510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028130"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /protein_id="WP_063796271.1"
                     /sec_met_domain="DUF692 (E-value: 3.6e-94, bitscore: 313.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAQGASPGPADLAAPLPGRFPASPTGVGLGLRWEILDDLLEGLD
                     AGAAPPLPFFEICPENIMRRGGFIPAALERVQARYPLLSHGIALSLGGLDPFDPAFLRE
                     LRGLLDSVDAPFHSDHLSFSGVEGRALHELLPLPRTSAAAAHVAARIREAQDRLGRRMA
                     IENITYYLVPGQAPLDEADFLVEVLERADCGLLLDVNNVYVNARNHGYDPARFLDKLPP
                     ERVVAMHVAGHEQRGPLLIDTHGAPPIDPVLQLLTRAVARTGPVPVVLERDHHVPPLAE
                     LLQELPAIETAYRAGLAEATVAPPLRTPSPRLLPDLAPRLDPGAPLFLALQRLVGAPQD
                     DTITRDPRAFLSTAGVSGPDLDAFAAVPEERLLVYRNLVRSRLRAAIAIEMPRTAARLG
                     ASFDTHVHRFLDEELPRSPYVRDVAFEFAQWASPRWTADPNLPDYLSDLARHELIGFAT
                     RAAAEPHRSPQDAPQPAPPPDAPLSLDRGVRFHASAALVRYEHAVHLLLDDETADDLPE
                     RRPTALFVYRDAEHEARYLELSPLAASLLENLLAGATLRDAVLTACTAERQPLDGPVLE
                     GTATLLADLSERGALLGPSPAP"
     gene            complement(6820..7182)
                     /locus_tag="CMC5_RS13885"
                     /old_locus_tag="CMC5_028140"
     CDS             complement(6820..7182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020739071.1"
                     /locus_tag="CMC5_RS13885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028140"
                     /product="hypothetical protein"
                     /protein_id="WP_050430867.1"
                     /transl_table=11
                     /translation="MLSKKSIYETLTALGAGAMISACGGSQTPVNATEVPAAQDATPAA
                     EDPATPADVTPDETPATAPPSEPGAAAAPVDPKPAETAQAPATPATAKPAPKPAAKKPA
                     AKKPDASAACGAGTCA"
     gene            7547..8182
                     /locus_tag="CMC5_RS13890"
                     /old_locus_tag="CMC5_028150"
     CDS             7547..8182
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020739069.1"
                     /locus_tag="CMC5_RS13890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028150"
                     /product="outer membrane beta-barrel protein"
                     /protein_id="WP_050430868.1"
                     /transl_table=11
                     /translation="MNTLGFVSMGFAVVAVGLTFTGAASAQSSSYARDYPDLNVRNVPP
                     SDKPLIRKIPQPDYSLEGGFGIVGYLDGAASIGPAWNVRFTAAFNQRFAGELSYMGSSS
                     SVAQTDSSLVMTALDASARFNILLADQAFVQPFVAAGLGYAGFAGEGGDPFTVTVPVAA
                     GVERLLTEHVKVGARFNVRPTFFDDIGTGPETQGADSWQVVGQVGGAF"
     gene            complement(8244..9053)
                     /locus_tag="CMC5_RS13895"
                     /old_locus_tag="CMC5_028160"
     CDS             complement(8244..9053)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025910.4"
                     /locus_tag="CMC5_RS13895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CMC5_028160"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_050430869.1"
                     /transl_table=11
                     /translation="MHVRWILACAVALTASTPGLAKAQSPASAPVAGDRERARALANEG
                     FGHFEAGKYEEALKAFEEAERNFHAPTILLMVARSHVQLGHHQEARAVFQRIIDEKLAN
                     YAPAEFFEAQQQARTEIAALPPASPGESPGAPTTSPIAPVSEPPSAPGDAQSSGSRSSG
                     SLLPAAIAFGVAGVGVGVGAVTGLMSFGVASDLEKSCDVSGRCPESERATKDKGMTLAT
                     VSTVSFVLAGVAAAAGVTLVVLRPGKSSQEPVNVVAGPGWMGVRGRF"
     misc_feature    9043..9056
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.45"
                     /tool="antismash"
     misc_feature    complement(9556..9570)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(10078..10087)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    10652..10665
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
ORIGIN
        1 gtgaaggcca tcatcatcgg cgcaggtcgc ggcagcaggc tccgtcacct cacggacgag
       61 attcccaaga ccctggtgca cgtactgggt cggcccatgc tcgacgccat cctggaggcg
      121 ctcgctgcag gcggtttctc gcgcaaagac gtggtgttca tctgcggcta ccggaaggag
      181 gtgatccagg aggcgtaccc cgatctgacc tatgtcgaaa atcgggactg ggagcggaac
      241 aacatcctgc tctctctcct ctgcgcccga gagcacctgg ccgagggctt cgtgtccacg
      301 tacgccgaca tcgtctaccg gccagccatc gtggccgatc tggtgcgctc accgcacgat
      361 ctcaccctgg cttgcgatac cgactggcgc cgtcgctaca tcggtcggtc ggaacatccg
      421 gagaccgatg ccgagaagtt gcgggttgaa ggagaccggg tggtggagat ctcccggcgc
      481 atcccgtcgg agctggccac gggggagttc attggcgtga tgaaggcctc agcagccgga
      541 gcggcgacgc tgaccagggc gttcgacgag gcgcaagcgc gcttcgccgg gcgtgagttc
      601 cgggaggggc gctcgttcga gcgggcttac ctgctggaca tgttgcagca catgctcgaa
      661 ggggggacgg cgatccacaa ggtggatacc cacggggggt acatggagat cgacacgctc
      721 caggatgccg cctctgccga gcgatggtgg cgcggggagt gaggtcttcc cgtcacggtg
      781 gggcgcggag cacgggcagc ttcagccgcg ctgccatggg ggagggctgc tcggccgtcg
      841 ggagcagctc ggccagggtg gcgcggtcca gcacggccat gaaggcctcc agcgcctcgc
      901 cgagcaaggc ctggagtccg caggcgcccg tgagaatgca gccgccgtag gtcggctctt
      961 tctggaaaca cgcgaccagg gccatgtcct cctcggtcca gcggatcaca tcgccgatcc
     1021 ggatctcggt gggagagcgg gccaggcgca ggcctccacc gcgtccccgc agcgtctcga
     1081 tgaacccccc ctgacccagg cggtgcacga ccttgaccat gtggttctcg gagacgccgt
     1141 atgcctccgc gatctggcgg atggagacga gcgcgtcggg ccgcatgccc acatagagca
     1201 gggcacgaag cgcgtagtcc gtatggaggg tgaggcgcat gtggaaaggt ataaatcgat
     1261 tgcatctttg aaccaggggt gactataaga ttcatgtttg atgcaccttt gaggaggatg
     1321 ccatgtcccg aaccctcagc gagcacacca tctcggtggt gaaggcgacc gtcccggctt
     1381 tgcaggcgca cggcgtgacc atcacgcggc gcatgtacga gcggatgttc aagaacgagt
     1441 cgatccgcaa tctgttcaac cagtcgcacc acggtgcgtc cggctcgcag ccccacgcgc
     1501 tcgccgcggc ggtgctcgcc tatgcacaga acatcgacaa cctcgcggtg ctggccccgg
     1561 ccatcgagcg gatcgcgcag aagcacgctg ggttgaacat cctgccggag cattatccgt
     1621 tcgtggcaga ggcgcttctg gcggccatcc aggatgtgct gggtgatgcg gccacgcccg
     1681 aggtgatgga cgcgtggggc gcggcctact ggttcctcgc cgaggtgctc atcgggcgag
     1741 aggcgcagat ctaccgtgag gcggcggagg cgcgcggagg ctggaacggc tggcgcgatt
     1801 tcgtggtcac cgagcgggtg cgcgagagcg actgcatcac ctcgttcacg ctggtcccgg
     1861 ccgatgggaa gcccgtgctc gagcaccggc ccggtcagta cctgaccttc tgggtggatc
     1921 tccccgggcg ttcccccctg aagcggaact acagcatctc gtccgcgccg agcgatgcgt
     1981 cgtaccggat cacggtgaag cgagagccgg aaggcacggt ctcgggctgg ctccacgacg
     2041 aggtgaaggt ggggacgcgc ttgaaggtgg cacccccggc cggagagttc ttcttgccgg
     2101 agacgcccgc gcgtccggtg gtgctgctca gcgggggcgt gggccagacg ccgttgctca
     2161 gcatgctgga caccctggcc gtacagcatc cggaggtgcg cacgcatttc gtgcatggcg
     2221 cgctgaacgg cgcactccac gcgctcggga cgcatgtccg gggggtggcg cagcagtcgt
     2281 cggggaacat cgccgcgacg gtgttctacg agaagccgcg caacgaagac cgccacgggg
     2341 tggactacga cgaagcgggc ctgatctcgc tcgactggct ccaggcgaac acgccgctgg
     2401 gggacgcgga ctactatctc tgcgggccgc ggccgttcct gcgcgccttc gtgggggggc
     2461 tgggcaagct cggggtgcca gccgcgcaga tccactacga gttcttcgga cctgcggacg
     2521 agctgctggc ctgagcgcgg agcccgagca ccgcgcctct tctcggtatc cgcagcgatg
     2581 ggctggaggg gtcgatgagg gccgacgcca cggcgccggc ccgcgccgac tcagagctct
     2641 ctggcgcagc gaaagccgat gccgggggca gaggccgtgg cgagctggtg gaagcggaac
     2701 gcggggttca gccagagcgc gaagcctccg ttgaagccgc cgccacggat cgccttccga
     2761 tcgccggcgg gagcgccctt cgggttgacc tgctcttcgt ccttgtagac ggcgaaccag
     2821 tcgccggtcc attcccacac gttgccgacc atgtcgttga ggccgaactt ggtcttgccc
     2881 ttggggaacg agccgacggg cgccgtgccg gggaagccat cattggcttc gtacatgcgc
     2941 tggctgggct tcgcgccgcg cgcggtctcc cactccgtgc actcggtgcc gcaggcgttc
     3001 atgaaggtgt gatcgccgac ctcgttcccc cacgggaact tccggccgtc ggagccgcgc
     3061 gcggcgtact cccactcggc ctcggtgggg aggcgcttct tctgcacctt gcagtaggcg
     3121 tccgcgaggt cccagctgac gcagttgatg gggtgcttgg tgagctcggg cttgccgaag
     3181 gtgcagtgct ccgagatcgt cttgagcagc ttctcgtgct ccgcgtcgct gaccgaggga
     3241 tccttgggga aggagatggc ttccgggggg cgcttgcagt cgccgacgtc ggagcaggcc
     3301 tggtactcgc cggccgtcac ctcgttgatg tcgatgcaga acgagtcgat ggtgaccttg
     3361 tgcgcgggtt gccagagctt gaaggtcggc tcgtcggagc ccatgaagaa gcggccaccc
     3421 gtgacgagcg ccatcccttc ggggcatccc ggaggagcgg ccgcgctcgt ggccgcgctg
     3481 gcgctcgcgc tgggagcgcc agcggcgacc gaggccgtgg gtgaggtgtc ggcggtggtg
     3541 gtcacctccg atccgccgcc gaggatcttc agggcggcga agccgccagc ggcgaggatg
     3601 acggcgccga gggcacccag aacgacgggg gccgcggagc gcttggtggg gacggccgtc
     3661 gaggtggagg gcacgaacga gccggagttc tcgggctgac gcgtgccacc gaccacggcc
     3721 gggcccgacc cggggaggct ggagggagga gaggcgcccg ctccggcgta gccaggcatc
     3781 gaggggagtg agctgcgtga tgggatcccc gaggacacga gcccgctgct cgtggccggg
     3841 ctccaggtgc cagcgtcggg gaagacggcc tggtgtaggg cagtccagaa ctgccccatg
     3901 gtcctgaacc gctcctgagg ggacacggcg agcgcctgca ggaggacggc ctcgacggtg
     3961 ctgccgagat ccagcccgaa ggcacgcgtg gtgggtcgcc ggatggggtc acggctctcc
     4021 acggcgagct gcatgtagtc gtcgccctgg agggcggact tgccggtgag gatctcgacc
     4081 aggatcagcg ccatggcgaa cacgtcggtc cacggtcccg tcgcgccgtg ggtacggctg
     4141 aactgctccg gggcgccgta gttcggcgtg aacgcggtga tgtcttgccc ggtgtgggcc
     4201 agcgcggctg cggccgcggc gtgctccgac atgaccttgg cgatgccgaa atcgaggacc
     4261 ttcacgtgga cgccgatccc gcgggggtcg ccgatcacga agatgttcgc cggcttgatg
     4321 tcacggtggg cgatgccacg cgcatggacc tgctccagtg cgaccgccgc cggttcgagc
     4381 aaggccatcg cctcgtgcaa gctgcggttc ggggcgccgc cctgtgtctc ctcccagagc
     4441 actgcgtcga ggggctttcc ttcgagccac tcgaggacca tgtacgggag ccactggccg
     4501 tcggggctgg tgaaggtacc gatgtcgcgg gcctgcacga tcgcggcgga gcggctcgac
     4561 agctcggcca tgaggcgccc ctcctggatg aagccgtcga gcagcttgtc gcgctggtcc
     4621 gcgggggcgt tggccaggat cttgaagcac ttcagcgcga cgggctgtcg ccagatggtg
     4681 tgctcggcct tgtagacgac gctgaagccg ccctcgccca ccgcgtggct gatcagatac
     4741 ttctctgcga tgagggtgcc cgagatgccg agcgggtcgc gggtgcgctg ggaactcata
     4801 agctccttcg aagaggggac ggcatcttag ccaggacgcg gcccgaagtg gaccttcctg
     4861 aacgctgggg ggcgcttcat ggagcgcgaa gaccaggagg cgtctcgctt cgcgcgcgcg
     4921 ttgccctgat tcttcaggtg ttttccagcg gtggggcaca atgggtcagg cgacccctgc
     4981 cggggtgccg agcgcggggg ctagggggca ggggaggggc ccagcagcgc tccacgctca
     5041 ctcaggtcgg cgagcagggt ggccgtcccc tccaggacgg ggccgtcgag gggctgacgc
     5101 tctgcggtgc aggcggtgag cacggcgtcg cgcagcgtgg ccccggcgag caggttctcc
     5161 aggagggagg cggccagggg gctgagctcg aggtaacgcg cctcatgctc ggcgtcgcgg
     5221 tacacgaaga gcgccgtcgg ccggcgctcg ggcaggtcgt cggcggtctc gtcgtcgagg
     5281 agaaggtgga cggcatgctc gtagcggacc agggcggccg aggcgtggaa ccggacgccg
     5341 cgatcgagcg aaaggggcgc gtcgggaggc ggtgcgggct gcggtgcgtc ctggggggaa
     5401 cggtgtggct cggcggcggc gcgcgtggcg aatccgatca gctcgtgtcg ggcgagatcg
     5461 gagaggtagt cggggaggtt cgggtcggct gtccagcgcg gggacgccca ctgcgcgaac
     5521 tcgaacgcga cgtcgcgcac gtagggagag cgcgggagct cctcgtcgag gaagcgatgc
     5581 acgtgcgtgt cgaagctggc gccgaggcgg gccgcggtgc ggggcatctc gatcgcgatc
     5641 gcggccctca agcggctcct cacgaggttg cggtagacga gcagccgctc ctcgggcacc
     5701 gcggcgaagg catcgagatc cgggccggag acgcccgccg tggagaggaa ggccctcgga
     5761 tcgcgggtga tggtgtcgtc ctgaggggct ccgacgaggc gctgcagcgc caggaaaaga
     5821 ggcgcaccgg gatcgaggcg cggggcgagg tcggggagga ggcgagggga gggagtgcgc
     5881 agggggggcg cgactgttgc ttcggcgagg ccagctcggt acgcggtctc gatcgcggga
     5941 agctcctgga gcagctcggc gaggggcggg acgtgatgat cccgttcgag cacgacgggg
     6001 accgggcccg tgcgcgccac ggcgcgggtc aggagctgga gcaccggatc gatgggagga
     6061 gcgccatggg tgtcgatgag cagggggccg cgctgctcgt gaccggcgac gtgcatcgcc
     6121 acgacgcgct cgggcgggag cttgtcgagg aagcgcgccg ggtcgtagcc gtggttgcgg
     6181 gcattgacgt agacgttgtt gacgtcgagc aggagcccgc agtcggcccg ctcgagcacc
     6241 tcgacgagga aatcggcctc gtcgagggga gcctggccag gcacgaggta gtaggtgatg
     6301 ttctcgatgg ccatgcggcg cccgagccgg tcctgggctt cgcggatgcg agccgccacg
     6361 tgggcggcgg cggcgctggt gcgagggagg ggcaacagct cgtgcagcgc tcggccctcg
     6421 acgcccgaaa aggacaggtg atcgctgtgg aagggggcgt cgaccgaatc gaggaggccc
     6481 cgtagctccc tgaggaatgc ggggtcgaac ggatccaggc cgccgagaga gagcgcaatg
     6541 ccgtggctca gcagggggta gcgcgcctgg acgcgctcca gggcggcggg gatgaagccg
     6601 ccgcggcgca tgatgttctc ggggcagatc tcgaagaaag gcagcggcgg cgctgctcct
     6661 gcgtcgagcc cttcgagaag atcgtcgagg atttcccagc gaaggccgag gccgacgcct
     6721 gtaggggatg cgggaaagcg ccccgggagg ggggcggcga gatccgcagg gccaggggat
     6781 gcgccctgag cggtcaccgt gatgctccgg caggctgggt caggcgcacg tccctgcgcc
     6841 gcacgctgcg gaggcgtccg gcttctttgc cgcaggcttc ttcgctgcgg gcttgggggc
     6901 gggcttcgcc gtggcaggcg tcgcgggcgc ttgcgccgtc tcggcgggct tggggtcgac
     6961 cggagctgcc gcggcgccgg gctccgaagg cggtgccgtg gcgggggtct cgtccggcgt
     7021 gacgtcggcc ggcgtcgccg ggtcctcggc ggcgggggtg gcgtcctggg cagcggggac
     7081 ctcggtcgcg ttgacggggg tctgagagcc cccgcaggcc gagatcatgg cgcccgcgcc
     7141 gagcgcggtg agggtttcgt agatgctctt cttggacaac atcgtgcgct cctggtgtgt
     7201 cccggttcta tgccaggacg tgtccggcgt cgaacgagtt cggcgccgtc gtccggccgg
     7261 ctcccgctgg gggcggaggc gcacatcacg cacccgtgat gcacatatct gctggcctac
     7321 gtcctgcagc gggccgtgcc gaacgcaggg gggggcgggg gtgcgagcca gggggacaac
     7381 cccggcagcc gcaccgtgac ggccgaaggg cggcagggaa cctgcgcaga cgcctggccg
     7441 acgacgctcg agctgggcgg tgaggctcac gagcgaggtg tggggtgcga acgcgcctcg
     7501 accgctcccg tgcggtgaga ctgaacaacg aggagaacag aggaccatga acacgctggg
     7561 attcgtgtcg atggggttcg cggtggtggc ggtgggtctg accttcaccg gcgctgccag
     7621 cgctcagtcg agcagctacg ccagagacta ccccgatctc aacgtccgca atgtcccccc
     7681 gtcggacaag ccgttgatcc gcaagatccc gcagcccgac tactccctgg agggagggtt
     7741 cggcatcgtg ggctacctcg atggggccgc ctccatcgga cccgcgtgga acgtccggtt
     7801 caccgccgcc ttcaaccagc gcttcgccgg agagctgagt tacatgggct catcgagcag
     7861 cgtcgctcag accgacagca gcctggtgat gacggcgctc gacgcctcgg cgcgcttcaa
     7921 catcctgctc gccgatcaag cgttcgtgca accgttcgtc gcggcggggc tgggctacgc
     7981 gggatttgct ggcgaagggg gcgacccctt cacggtcacg gtgcccgtgg ccgcaggggt
     8041 ggagcggctc ctgaccgagc acgtgaaggt gggagcgcgg ttcaacgttc ggcccacgtt
     8101 cttcgacgac atcgggaccg gacccgagac acagggcgcc gactcatggc aggtcgtcgg
     8161 tcaggtgggc ggcgcgttct gacctgaagg tttggcctcc cacggcggga gaacaccagc
     8221 gacatttcgg gcgcacgctt ggctcagaaa cggccgcgga cgcccatcca gcctggaccc
     8281 gcgacgacgt tcaccggctc ctggctcgat ttgccagggc ggaggacgac cagcgtgaca
     8341 cctgcagccg cggcgacgcc cgcgagcacg aagctcaccg tggagaccgt cgcgagcgtc
     8401 atccccttgt ccttcgtcgc cctctcggac tccgggcatc gcccgctgac gtcgcacgac
     8461 ttctcgaggt cgctggcgac cccgaacgac atgagccccg tgacggcccc gacgccgacg
     8521 ccgacgcctg cgacgccgaa cgcgatggcg gcgggcagga gagagcccga gctgcgtgac
     8581 ccgctgctct gcgcatcgcc gggagcagaa ggcggctccg agacgggcgc gatgggggag
     8641 gtcgtcggcg ctccgggcga ttcgccggga gatgccggag ggagcgccgc gatctccgtg
     8701 cgcgcttgct gctgggcctc gaaaaactcg gcgggcgcgt agttggcgag cttctcatcg
     8761 atgatgcgct ggaagacggc tctcgcttcc tggtgatggc cgagctgaac atggctccgt
     8821 gcgaccatca gcaggatcgt cggcgcgtgg aagttgcgct cggcttcctc gaaggccttc
     8881 agggcctcct cgtatttgcc tgcctcgaag tgaccaaacc cctcgttggc gagcgcgcgc
     8941 gcccgctcac gatcaccggc gaccggggcc gaggccggac tttgggcctt cgcgagcccc
     9001 ggggtcgacg ccgtcagcgc gaccgcgcag gcgagaatcc atcgaacgtg catgcagcca
     9061 cccaccgggc ggaagctacc agagaccgga ccgaaaaggt gagccagaga tctctccggg
     9121 ccctcactcg gcgttggcat cgctcgtcgc gggtcgggac gaccagcgat ccgacccgtg
     9181 acgaggcgcg gtctccggcc gctcacgaac cgataccgcg gtgacgaccc cctccacgac
     9241 ccggtccagg atctcgggcc ggatgggctt gacgacatgc tcgtcgaagc cggcgtcgaa
     9301 ggcggcttgt tgatcctcgg gccggccgta gccggtgagg gccaccaggt acaacccgtc
     9361 cttcccgcac gcgcggcgca cgcgccgagc cacttcgtag ccgttgacct cgggcagccc
     9421 gatgtcgacg agggccaggt cgggcttctg ctggatgatg gcctcggctc cctccgcacc
     9481 ggtgcagaag gaggtgacgg tgtggccgtc ttgcatcagc agcacctcca gcatctcgcg
     9541 gccgtcgtcg ctgtcctcga cgaggatgat ggacagcggg cgggacacgg atggcgacgc
     9601 ggacggcgac gcggcagggc gcagcgtgct ggccacgagc tgaccctgcc agagagggaa
     9661 ggaggccacg aactcgctgc cccgccctgg gccgtcgctc gaggcggaca cgcgcccacc
     9721 gtggaggccg acgaccgcct gcaccagaga gaggccgacg ccgatgcccc ccgacgagcg
     9781 atccagcgtg gtctcgcgct gatagaacag ctcgaaaacc cggtcgaaat cctccttcgg
     9841 gaggcccacc ccggagtcgc gcacgcggat gacggcctga ttcccctctc gccgcaccga
     9901 gagccagatg cgacccccgg caggggtgaa cttggcggcg ttcgtgagca tgttgctctg
     9961 cacctgctgc aggcggtgca gatcgccgcg tacggcgacc gggaggggct ccaggtcgac
    10021 atgaagctgg agcttcttgc tctcgaccag tggctgcacc gcctgcagcg ccgcctccgc
    10081 cgccttccgc aggtcgaggg gctccgcccg gatctcgatc ttccccaggg tgatccgggt
    10141 gatgtcgagg agatcgtcca ggagccgcgc catgtgcagc gcctgccgct tggtcacgtc
    10201 gagcgcggag cgggtcgccg acgtgtcgag ctcgctgcgc tcgatggtgt acgtggcgtt
    10261 gagcactgct gcgagcgggt tgcgcagctc gtgggagagc atggcgagga agtcgtcgcg
    10321 ccgcttgagg gccgtgcgat cgcgctcctc ggcgtccttg cgcaccgtga tgtcctcggc
    10381 gatgcctgcg atcgcgtaga cctcaccgct ggtatcgacg agggggaagc gcaccgtcag
    10441 gtaggtgcgg actgcgccat cgtactcgat ctgctcctcg acccggagca cctcgcgggt
    10501 ggaggcgacc tgctcgtcgc gttcgcgccg gagggacgcg agcttcgggg gaaggagccc
    10561 ctcatcggac tcgccgatga gcaagtccgc gcgcgcaccg agcacctcgg ccgccacgcg
    10621 gctgacgatc tggtagttgc ccctgcggtc cttgacccag atggagagcg gcgcgtgatc
    10681 gaggatggcc cgcatctgct ccccacggag gcgcgcccgc tcctcgctcg tccgcagctc
    10741 gcgctcggcg tccttgaggg ccgagagatc gaccagcgtg agcaccaccc cctcgaccgt
    10801 ctggcgcggc cggtagggca gaacgcggag caggtagtgg cgcccgcgga gatcctgcac
    10861 ctcgcgctcc acgcgctcgg ctccatggag cacgccttcc agatcccgca cgatgccctc
    10921 gtgccgtagc ttgtgcgtga agctgtcgat cctccgcccg atgtcctgcg gcagcagact
    10981 gaacgtctcg gcgatcttcg gcgtcaaccg acggatgcac agctccttgt cgaggaagag
    11041 gatctgcacc tccgtgctct ccaggaggtg gttcatgtcc gtggtcagct cggtgagctc
    11101 ggcgatcttg gcctgatact ccgcgttgac ggtgtacagc tcctcgttga cgctctgcag
    11161 ctcctcgttg gtgctctgca gctcctcgtt cgaggcgatc agctcctcgt tcgtcgcttg
    11221 cagctcctcg ttgctggtct ccatctcctc gagcgtggcc tgcaggttct cctgcgtatg
    11281 gcgtagctcg tgttccagcg tctcgatgcg ctcctgcgtg agcatgttga cgggcatctc
    11341 gtcttgccct gggctcgctg actgcgtggt cgccggctcc agggtgacga gcagctgctg
    11401 gttgtcctcg gctccaccga gggccatcac cgagacgcgc acgaggcacg acccgtcggg
    11461 ggtgcgcgcc gggacccgct cgtagaaggc aggttcgtct cccttgcccg cgcgcttgag
    11521 cgccgaggcg acggcgaatt tcagctcccc atccagcaga tcgaggacgt tcagggacgg
    11581 ccttccatcg tggtaggcga ggaagcgtcc tcccccgccg aaggagtgca gcagctcccc
    11641 ggtcggtgtc accagcaggc tgggcggcgt gaaccgctcg aggagcgcgt gctgcgcctt
    11701 ggtgatcgcc ctctcctgga tgctccgacg atccagcaag cgttcgccgc gctcgcgtcc
    11761 tccctcctga ccccgcaggt ccggggtgat gcgcagc
//
