LOCUS       NZ_KQ257858            22580 bp    DNA     linear   CON 02-JAN-2025
DEFINITION  Streptomyces stelliscabiei strain P3825 scf_652_39.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ257858
VERSION     NZ_KQ257858.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces stelliscabiei
  ORGANISM  Streptomyces stelliscabiei
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 768815)
  AUTHORS   Harrison,J., Sapp,M., Thwaites,R. and Studholme,D.J.
  TITLE     Genome sequencing of plant-pathogenic Streptomyces species
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 768815)
  AUTHORS   Harrison,J., Sapp,M., Thwaites,R. and Studholme,D.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JUL-2014) Biosciences, University of Exeter, Geoffrey
            Pope Building, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001189035.1-RS_2025_01_02
            Annotation Date                   :: 01/02/2025 01:49:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,536
            CDSs (total)                      :: 9,455
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 81
            rRNAs                             :: 4, 2, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 2, 1, 3 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 482
            CDSs (without protein)            :: 482
            Pseudo Genes (ambiguous residues) :: 0 of 482
            Pseudo Genes (frameshifted)       :: 129 of 482
            Pseudo Genes (incomplete)         :: 407 of 482
            Pseudo Genes (internal stop)      :: 20 of 482
            Pseudo Genes (multiple problems)  :: 69 of 482
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:19:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 65988
            Orig. end                         :: 88568
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ257858.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22580
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22580
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22580
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12580](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12580)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     tRNA            58..130
                     /anticodon=(pos:66079..66081,aa:Gly,seq:gcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IQ64_RS12760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="IQ64_13510"
                     /product="tRNA-Gly"
     gene            58..130
                     /locus_tag="IQ64_RS12760"
                     /old_locus_tag="IQ64_13510"
     gene            complement(178..1077)
                     /locus_tag="IQ64_RS12765"
                     /old_locus_tag="IQ64_13515"
     CDS             complement(178..1077)
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999962.1"
                     /locus_tag="IQ64_RS12765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13515"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_046914968.1"
                     /transl_table=11
                     /translation="MSGFVEKPEPIQVPGLVHLHTGKVRELYQNEAGDLVMVASDRTSA
                     FDWVLPTEIPDKGRVLTQLSLWWFDQLADLVPNHVLSTELPPGAPADWAGRTLVCKSLK
                     MVPVEAVARGYLTGSGLLEYNDSRTVCGLALPEGLVDGSELPAPIFTPATKAAVGEHDE
                     NVSYEEVARQVGAETAAQLRQTTLAVYGRARDIARDRGIILADTKFEFGFEGDTLVLAD
                     EVLTPDSSRFWPADLWKPGRAQQSYDKQFVRDWLTSDASGWDRASEQPPPPLPEEIVAA
                     TRAKYVEAYERLTGIGWS"
     gene            complement(1163..2674)
                     /locus_tag="IQ64_RS12770"
                     /old_locus_tag="IQ64_13520"
     CDS             complement(1163..2674)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330652.1"
                     /locus_tag="IQ64_RS12770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13520"
                     /product="N,N-dimethylformamidase beta subunit family
                     domain-containing protein"
                     /protein_id="WP_050398384.1"
                     /transl_table=11
                     /translation="MGSEQHHIRRWESGALAHAVTDPFGQGPVPWLRGNVTYFDDTGQV
                     VPWYVDPGPPEPPASARGTRARVPAPRVPPGPRSADDVRRQIKGFAATGAAAPGQSIDF
                     HVTVDPPQEFGVDIYRIGHYSGDGAAKITTSPRLSGIVQPPPLTADRTVSCHHWWLSWR
                     LQIPSYWNVGAYVAVLTTADGYRSHVPFTVRDDRPADLLLLLPDITWQAYNLYPEDGRT
                     GASLYHAWDEDGRLLGESEAATTVSFDRPYAGAGLPLHVGHAYDFIRWAERYGYDLAYA
                     DARDLHAGRVDPSRYRGLVFPGHDEYWSPQMRRTTELARDSGTSLVFLSSNTMYWQVEL
                     SPSPSGAPDRLLTCRKRRGPGKPALWREVDRPEQQLMGIQYEGRVPEPHPLVVRNADHW
                     LWDATGAHENDELAGMVAGEADRYFPRTPLPEHQGRMLLAHSPYRDKDEVVRHQETSLY
                     RAPSGAWVFASGTFAWSPALDRPGHVDTRVQRATANLLDRICKRD"
     misc_feature    complement(2913..2928)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.52"
                     /tool="antismash"
     misc_feature    2914..2928
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.15"
                     /tool="antismash"
     gene            complement(2938..5058)
                     /locus_tag="IQ64_RS12775"
                     /old_locus_tag="IQ64_13525"
     CDS             complement(2938..5058)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482693.1"
                     /locus_tag="IQ64_RS12775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13525"
                     /product="membrane protein"
                     /protein_id="WP_046919805.1"
                     /transl_table=11
                     /translation="MAGGEEAGAQAARARALAVLRVRSRALAVAVLPAAVAVVLVVGGS
                     TGRLTGPGWSMASRIVSGLALVVLLAATGIALVVARARPAVSPTVTVTEKAAPDLYRLV
                     RDLADRLDVPPPSAIALTPDCDSWLEDRTHPSHHQPDAPRHSSNDGADGSEVVDGGGAT
                     AGDRGTGRDDEMTDTRGSSPGLPSRPQSRLASGPESGLSSHRRHRAPTAPVLVIGSPFL
                     WWMRVGELRAVLAPVVAGTGPSAHPDIAAARRFVRGLDAAVAVSSAPSHGVAVRTALGG
                     VGWVTRMLLRGCRGHAAEMERGVAAAAAERAQAVDYGLRIVAQEQVGLAYAGWDRLLTR
                     VALPAWRMGRWPSRLDAGVVAALTELSRRDRLAEGFASRLGERPACDLLEEPGTVDEAA
                     SLLAARLFHGGPAESGPDWSPVDWHEYPDEVVDRKWRADAARLHRVLDGLGVRHPASDP
                     TTDPTGPAHGGPTLSRVLTHLTTAAAAAPHPPATEAAEVPGAGPGTTTAPHGHPSPHPA
                     AGRATAAEADREHEHNPDLEPDSHHISPHDAGVTTAPGPDLDSDSDDESGLATPQSAAL
                     AAALTAELAREEATVPADGHPAAGGAEAQGPDRALWDDGLLPLFPMQPPRTGRELLTEH
                     VAAMVCCAAMDTAGATPGLDWLDGPSLLVDGVRAADLAPRVLTLVEDGDPVPLRDWLSR
                     LGVRPEKPVRLV"
     gene            complement(5519..6772)
                     /gene="purD"
                     /locus_tag="IQ64_RS12780"
                     /old_locus_tag="IQ64_13530"
     CDS             complement(5519..6772)
                     /EC_number="6.3.4.13"
                     /GO_function="GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA]"
                     /GO_process="GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982977.1"
                     /locus_tag="IQ64_RS12780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13530"
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="WP_046919804.1"
                     /sec_met_domain="ATP-grasp (E-value: 1.1e-07, bitscore:
                     26.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVLVIGSGAREHALCRSLSLDPDVTALHCAPGNAGTAEVAESHP
                     VDALDGAAVTALATRLEADLVVVGPEAPLVAGVADAVRAAGIPVFGPSGEAARLEGSKA
                     FAKEVMAGAGVPTARSYVCTTAEEIDEALDAFGAPYVVKDDGLAAGKGVVVTADLAQAR
                     EHALACGRVVIEEFLDGPEVSLFAITDGVSVVPLQPAQDFKRALDGDEGPNTGGMGAYS
                     PLPWADPKLVDEILQTVLQPTVDEMRRRGTPFSGLLYAGLAITGRGVRVIEFNARFGDP
                     ETQVVLARLKTPLAGVLLAAANGTLGDLEPLRWSADAAVTVVVASHNYPGSPRTGDPIT
                     GLDEIAAVDAPHAYVLHAGTRRVGDEVVSAGGRVLSVTATGEDLTQARDRAYTAVARIG
                     LDGSQHRSDIAAKAAAEA"
     CDS             complement(6918..>7747)
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115780.1"
                     /locus_tag="IQ64_RS50750"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13535"
                     /product="DNA polymerase III subunit gamma and tau"
                     /pseudo=""
                     /transl_table=11
                     /translation="ASAGGGRRPGGWPTAAPAGGGPGPAPAAPAAPPAAGPSAAYAQPS
                     APTAPQAPAAHNPAPGGPDPRTLWPNILETVKNRRRFTWILLSQNAHVTGFDGTTLQIG
                     FVNAGARDNFASSGSEDVLRAALAEQFNVHWKIEAVIDTSGGSAAPVAPGGYGSPAPAA
                     GGYGGGGTGGGYGGGGAGGGYGGSPAPAPRPASPPSSTAARPASPGPAAPPRSAPAAPP
                     VAAAPPSPPEPPPVSPEDDTPEDDDPDLDESALSGHELIVRELGATVVEEITNE"
     gene            complement(6918..>7749)
                     /locus_tag="IQ64_RS50750"
                     /old_locus_tag="IQ64_13535"
                     /pseudo=""
     assembly_gap    7750..7786
                     /estimated_length=37
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<7787..9167)
                     /locus_tag="IQ64_RS50755"
                     /old_locus_tag="IQ64_13540"
     CDS             complement(<7787..9167)
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673617.1"
                     /locus_tag="IQ64_RS50755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13540"
                     /product="DNA polymerase III subunit gamma and tau"
                     /protein_id="WP_233443404.1"
                     /transl_table=11
                     /translation="MSSLALYRRYRPESFAEVIGQEHVTDPLQQALRNNRVNHAYLFSG
                     PRGCGKTTSARILARCLNCEQGPTPTPCGECQSCQDLARNGPGSIDVIEIDAASHGGVD
                     DARELREKAFFGPASSRYKIYIIDEAHMVTSAGFNALLKVVEEPPEHLKFIFATTEPEK
                     VIGTIRSRTHHYPFRLVPPGTLREYLGEVCGKEKIPVDEGVLPLVVRAGAGSVRDSMSV
                     MDQLLAGATDEGVTYAMATSLLGYTDGSLLDSVVEAFAAGDGAAAFDVVDHVIEAGNDP
                     RRFVADLLERLRDLVILAAVPDAVEKGLIDAPVEVLERMQAQAGVFGAAELSRAADLVN
                     EGLTEMRGANSPRLQLELICARVLLPATYGDERSVMARLDRLERGINFAGGGAGPALGY
                     VPGPEAHGGAAAPPLGTGVTPQAGPPAHAPQTEQVPPGGGPAAARAAARGAAGATGASG
                     PD"
     ncRNA           complement(9346..9442)
                     /db_xref="RFAM:RF00169"
                     /gene="ffs"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="IQ64_RS44900"
                     /ncRNA_class="SRP_RNA"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="signal recognition particle sRNA small type"
     gene            complement(9346..9442)
                     /gene="ffs"
                     /locus_tag="IQ64_RS44900"
     tRNA            9573..9660
                     /anticodon=(pos:75595..75597,aa:Ser,seq:gga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IQ64_RS12790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="IQ64_13545"
                     /product="tRNA-Ser"
     gene            9573..9660
                     /locus_tag="IQ64_RS12790"
                     /old_locus_tag="IQ64_13545"
     gene            complement(9741..10004)
                     /locus_tag="IQ64_RS12795"
                     /old_locus_tag="IQ64_13550"
     CDS             complement(9741..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482710.1"
                     /locus_tag="IQ64_RS12795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13550"
                     /product="hypothetical protein"
                     /protein_id="WP_046916150.1"
                     /transl_table=11
                     /translation="MTDHRVVLIEPRPTEAAGAPELAAVRFLALLPEDWHYEPHVKGTR
                     FTVRLSHPSRPTPIPDLNHTLNRIFTDPSLQAWHWTDITHLD"
     gene            complement(10001..12580)
                     /gene="lanKC"
                     /locus_tag="IQ64_RS12800"
                     /old_locus_tag="IQ64_13555"
     CDS             complement(10001..12580)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482712.1"
                     /locus_tag="IQ64_RS12800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13555"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_046916149.1"
                     /sec_met_domain="micKC (E-value: 2.9e-217, bitscore: 718.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.8e-11, bitscore: 39.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 4.9e-07, bitscore: 25.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.9e-12, bitscore:
                     40.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYVTYCQAGNAFYEDPATATAPTEPADAVAQAPAGWTRTVNA
                     DWVVLTPPHTELPGQGWKIHVSATRDNADRVLAAVRAYCVRERLTFKYIRSAEVLNRRN
                     SKYGDRGASGKFITVYPPDEPQLERVLVDLDAEVGGEPGPYILSDLRWRSGPLYVRYGG
                     FVARLGRDAKGDPVHCIEDPDGRLVPDVRGPGFRPPAWVTLPDCLAESLAARNASTMGD
                     FPFRAVRALHFSNGGGVYEAQDLRQGSGTEATVLLKEARPLAGLDEEGEDAVTRLERER
                     WALERLAGLDCVPPLIDYRKGREHYFLAREFVPGASLHTRIHESNPLLNPDADASSESF
                     TAYTSWALSLLDQIDAGVRAMHDRGVVFGDLHPNNVLVRPDDSIAFIDLETATPVDAMA
                     AQSIGAPGFRAPAGCTGPAVDRYALGCLRLAVFLPLTVVLNWGPEKTEQLITLVTENFP
                     VPADFAERVVADLTAAHDTAEGKGAGTDAHAGTAAHAETAASAAAPAPVWPDTLTPADW
                     SSLRASLAAGILATATPDREDRLFPGDIAQFTTPGGGLALAHGAAGVLWALGGAGTEIP
                     AAHTDWLTERVRRWTEPRPGFYDGLHGIAYALDALGRTVEAHEVLDRALALPLDDVDGS
                     LFAGLPGIGLSLLHFGHLDAAERLAELVADRTPGGYAARPRPGLLHGATGAALFLLRLY
                     ERTGDPKLLHTAVEGLRHDLAELSTGPGISRMPYLAVGGAGTAMVVSDVLAHLPSPDPA
                     LHDALPLLHSSLASPYQAQAGLFQGRAGATLALRRLHGRTPGPETEAAVHRHLTAFGWH
                     AIPYAGHPAFLGDQTLRLSTDLATGTAGVLLALDDALGSGEGLPFLS"
     gene            complement(12608..14275)
                     /gene="mpaP"
                     /locus_tag="IQ64_RS12805"
                     /old_locus_tag="IQ64_13560"
     CDS             complement(12608..14275)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mpaP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002407.1"
                     /locus_tag="IQ64_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13560"
                     /product="daptide biosynthesis intramembrane
                     metalloprotease"
                     /protein_id="WP_046916148.1"
                     /transl_table=11
                     /translation="MSSTPAGAVLLAPERLARPRLAPDVVVHEPAEPGAPWVVQRGSHQ
                     YFRLQEDLARLVRAVDGVRDHDDLADALGAPWTQADVGSAVRTLAGAKVLDDGVPKKDR
                     SSWFRFVPPLTLQFTLLKPDRLLARLAPLVAAAAHRGAAVAASAVTIGGLLVLAFQGAD
                     LQGALGRPFAPLLYLCVIGAVLATTAVHEIGHGAVLTYYGGRPTRMGMMLFYMSPAFFC
                     DVSDGWRLPRKEQRVRVALAGIATQTVIAGAAALATLFMGASAARDGVLVYAVVTYLSG
                     VLNLLPFVKLDGYIALMSHLDIPHLRDRAMTDARRWLARMLAGGTGYRRELPGVRWAVP
                     FGLLCMTFPLYIVAGAITLWSDSLQRLGALGALLVLCGIGYFLHHLARGVRRFAREART
                     AGGSPWRLGAVLALAAAALAVLGQLVQVPYTVNGGYTTAEDGRVTLLLPQSTDRALITS
                     GAPVRLYRAGIATRTRTGAATVAVDGADGKDAMAPLSALIPVRSDALPTPALGLPLDLR
                     GGRDRAPADPSGAAQLDAGSRPGWEWLYTKYVAPAWRW"
     gene            complement(14503..15246)
                     /locus_tag="IQ64_RS12810"
                     /old_locus_tag="IQ64_13565"
     CDS             complement(14503..15246)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002406.1"
                     /locus_tag="IQ64_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13565"
                     /product="ABC transporter permease"
                     /protein_id="WP_046916147.1"
                     /transl_table=11
                     /translation="MRNLLAGEWTKAWTGRGWLILAGCGVLMSLLGALGYASQGVTAIE
                     EGTMGRAAVTDDIVRSWFMMSLFTSLFGAVFVSREYTSGAIGRSVLMSGGRTRLLAAKV
                     LTATAVGALAALLTAALSLASAWGTLAANGTKPAWHGETWLILLGVFAVNTLAAPWGAL
                     VGWIVRHQVGAVVTVVALTLVVDPAVQVLVPEAGKYLMTIAQSSVYRDQKPDLLSTPLA
                     LLVIVGWLTAAALLARKLFTARDVV"
     gene            complement(15239..16060)
                     /locus_tag="IQ64_RS12815"
                     /old_locus_tag="IQ64_13570"
     CDS             complement(15239..16060)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482718.1"
                     /locus_tag="IQ64_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13570"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_046916146.1"
                     /transl_table=11
                     /translation="MSTANPSSTAGAPVVALRGLTKRFGEVTAVDDLTYEVRPGRIVGL
                     LGRNGAGKTTSLRMLLGLCRPTSGEATVFGRPYAELPHAARRVGVSMDAVGPLPGASAR
                     RELTIWARTLGLPRQRVEEVLDLVGLADGNAASRPVKGYSTGMKQRLALATALLPDPEL
                     LVLDEPANGLDPDGIRWLRGLLRGLADEGRTVLVSSHLLSEVEQTVDDVVIIQSSLRYA
                     GPLDGLVGTGEGERLEDRFFSLVGSPTTASTAPAVSTVPAASFAVGGQSHA"
     gene            complement(16057..16254)
                     /locus_tag="IQ64_RS12820"
                     /old_locus_tag="IQ64_13575"
     CDS             complement(16057..16254)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482720.1"
                     /locus_tag="IQ64_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13575"
                     /product="hypothetical protein"
                     /protein_id="WP_005482720.1"
                     /transl_table=11
                     /translation="MANSRDKAAAENKNLAFACALIPLGMAVATSQLSGGVEIFVMAGL
                     GAVMLSCLVKIGANLRKARR"
     gene            complement(16525..16680)
                     /locus_tag="IQ64_RS49250"
     CDS             complement(16525..16680)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482722.1"
                     /locus_tag="IQ64_RS49250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="daptide-type RiPP"
                     /protein_id="WP_005482722.1"
                     /transl_table=11
                     /translation="MKDNVTQEPTGFDASLELGMQELEAMEAPGFWSGFKTGVVISTVA
                     SAVIAT"
     misc_feature    16709..16722
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.45"
                     /tool="antismash"
     gene            complement(16738..16911)
                     /locus_tag="IQ64_RS49255"
     CDS             complement(16738..16911)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002403.1"
                     /locus_tag="IQ64_RS49255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="daptide-type RiPP"
                     /protein_id="WP_005482724.1"
                     /transl_table=11
                     /translation="MQENFENDNFSSALELGMQELEAMEAPGWWTAGGVVVGATVVSAV
                     GVSTGVAVSIIT"
     gene            complement(16989..18251)
                     /gene="mpaC"
                     /locus_tag="IQ64_RS12825"
                     /old_locus_tag="IQ64_13590"
     CDS             complement(16989..18251)
                     /codon_start=1
                     /gene="mpaC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482727.1"
                     /locus_tag="IQ64_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13590"
                     /product="daptide-type RiPP biosynthesis dehydogenase"
                     /protein_id="WP_046916145.1"
                     /sec_met_domain="Fe-ADH (E-value: 7.6e-38, bitscore: 125.5,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHGRGGPTRALIGPDALTAWLPDGGGRTAALLVDTAVATAGITA
                     LVQDRLGRARWRTARTPLAAGPGDLDAAAALAESLADEEAEVGLVVAVGGGSVLDLAKI
                     AALLRANPVAYTRLTVPQRGGLMGLPGEVTRTVPLLAVPTTLGTGSEMSAVACLAYPQG
                     KRLILGGVLRPEAALLDPSATVTLPRELVVEGVLEALFRAVSPYAGDHREDRRTEDRLT
                     ETVARRLVQLGYEAVREEEPGDALRLDIAKLSGLTHGEWLHQGRDPYAVKGWLIANEMS
                     SALGVRKMTAVAALLPHLWRAVLDGEPRLGSAPRLRRMWAGLREAASADRGRALPEDPA
                     DGIAALMDDWRVGRRLTAEGPGRIEALAERTVRAWGAGLPMLGGLRAEDVRRLLDAALG
                     TTPTRTAHAAPTAHAALTAHI"
     gene            complement(18248..19546)
                     /gene="mpaD"
                     /locus_tag="IQ64_RS12830"
                     /old_locus_tag="IQ64_13595"
     CDS             complement(18248..19546)
                     /NRPS_PKS="Domain: Aminotran_3 (27-355). E-value: 6.4e-66.
                     Score: 214.6. Matches aSDomain:
                     nrpspksdomains_IQ64_RS12830_Aminotran_3.1"
                     /codon_start=1
                     /gene="mpaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482729.1"
                     /locus_tag="IQ64_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13595"
                     /product="daptide-type RiPP biosynthesis aminotransferase"
                     /protein_id="WP_046916144.1"
                     /sec_met_domain="Aminotran_3 (E-value: 8.5e-67, bitscore:
                     220.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPGTTKNALWPSLLAPALHGSDALCAVSAHGVRVRYADGSELLD
                     ASSGLWNTNIGYGNEAIARAAADALRDASYLSVFRYENSYARAAAAALVELCGADTYGR
                     VLFSTSGGAANDLVMKLARHYHALRGEDRRRLVVGLRGSYHGLTYGSFALTGEDLGQQV
                     YGVDQRLIRHVDPNDPVGIRTLMERQGPMVAAVVVEPVLGSGAVPLTEEYVDELLRLRD
                     EYGFLLVADEVATGFGRTGDFFASQRWSARPDLLVTSKGLTNGTGAAAAVIASHTVADA
                     FDTAGAMLTHGETQAGTPVTCAVILATIAEMRRLDAVALGRALALRLDAELTRLVDEHP
                     WVTGTTGVGCFRSLRLTTPDGEPLPQARVPELVAAIRTAGAIVHPGVHGIQLFPALTYT
                     DADLTELTDRIRAGLALFTDLFTSDSVQAEVAA"
     aSDomain        complement(18482..19465)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ64_RS12830_Aminotran_3.1"
                     /evalue="6.40E-66"
                     /label="IQ64_RS12830_Aminotran_3.1"
                     /locus_tag="IQ64_RS12830"
                     /protein_end="355"
                     /protein_start="27"
                     /score="214.6"
                     /tool="antismash"
                     /translation="VSAHGVRVRYADGSELLDASSGLWNTNIGYGNEAIARAAADALRD
                     ASYLSVFRYENSYARAAAAALVELCGADTYGRVLFSTSGGAANDLVMKLARHYHALRGE
                     DRRRLVVGLRGSYHGLTYGSFALTGEDLGQQVYGVDQRLIRHVDPNDPVGIRTLMERQG
                     PMVAAVVVEPVLGSGAVPLTEEYVDELLRLRDEYGFLLVADEVATGFGRTGDFFASQRW
                     SARPDLLVTSKGLTNGTGAAAAVIASHTVADAFDTAGAMLTHGETQAGTPVTCAVILAT
                     IAEMRRLDAVALGRALALRLDAELTRLVDEHPWVTGTTGVGCFRSLR"
     gene            complement(19543..20391)
                     /gene="mpaM"
                     /locus_tag="IQ64_RS12835"
                     /old_locus_tag="IQ64_13600"
     CDS             complement(19543..20391)
                     /codon_start=1
                     /gene="mpaM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482731.1"
                     /locus_tag="IQ64_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13600"
                     /product="daptide-type RiPP biosynthesis methyltransferase"
                     /protein_id="WP_046916143.1"
                     /transl_table=11
                     /translation="MTTTLTTTTAPTSPTAPTTIPGRAGELLARLGSRAVTGDLYAEAG
                     AQVYHDVAGRSTHEVRELTGLVRTLPGDVLDLAAGSGRLTMPLLALGRRVTALDLSPYM
                     LRLLEDRLAAAPAALRERCTVVEADMSAFALGRTFPVIVLGTTSVSLLDERGRTGLYRA
                     VRRHLAPGGRFLLSTVGMDTDSGQPAEAELVVEAEAGRAYRMFEHWAVGDSARTVTVFP
                     ARIPDDDSPVQVTTTSVGVLPAALLEAELAAAGLTVRARHPLPAVGSRHHDVLLETEVT
                     S"
     gene            complement(20399..21559)
                     /gene="mpaB"
                     /locus_tag="IQ64_RS12840"
                     /old_locus_tag="IQ64_13605"
     CDS             complement(20399..21559)
                     /codon_start=1
                     /gene="mpaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002399.1"
                     /locus_tag="IQ64_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13605"
                     /product="daptide biosynthesis RiPP recognition protein"
                     /protein_id="WP_318787710.1"
                     /transl_table=11
                     /translation="MADLKERLIRWGTGTSSAGAGTEIGTGIGTKTGTGPGTNIGSGTG
                     TETGTETGTRIGELPYAGVETVVLEDREHLTAILHSGVVGADTLVLVPGGPGDSEGPGE
                     ESGADGHRVVGYEGSLAGAGGEFSPGAGFYLQIQGYGISEYMSVAGPTLVRIADDTDFD
                     VFLADADRALLDGTFPDFLTHPAIQLADLPGLGAGRTPAAGPRHRLYVGADGAVSTAPG
                     GTRLGTAGDGPDLLDARWRRLHSGTETTCVVCLGTVVDHDLRRTALAARPWLGRYLAAL
                     AAIRSLRARGVDGTIRVSGFGGRITEALATDADADLRDADAPLLLWTDQDVYVHAPAPG
                     RTFSVERSAATPVEALLACGSAEAAARYADPDHTVRIERFLARAGV"
     gene            complement(21580..22563)
                     /locus_tag="IQ64_RS12845"
                     /old_locus_tag="IQ64_13610"
     CDS             complement(21580..22563)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002398.1"
                     /locus_tag="IQ64_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_13610"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_046916141.1"
                     /transl_table=11
                     /translation="MTSYSVLLPFPPRRPEQILPYAGLVHWSNASRLWQGQSVMIEPHQ
                     GFVAAAGAGFRVPTGLGVTLMPLRHPYEAALQARSLAMATGQPVIAGFGPGGRPLQRSL
                     LGEAYRSPLTAAREYLSIVRGLLAGESVDIRGEYFSCRAEMPRYPVPGVEIGLGVLRPG
                     MARLAGEVADVAVTWLTPAHYLRDTVLPAMREGAANAPDAKGGAGRTPPRLTAIVPLAL
                     ARPDREPAELALASNAAHLQGAHYIDMLRRSGTDVAGDDPAANAKALVDGGAFLSGDPD
                     ELVAKLGAFDAAGVDEVVLNLTGVCNLYGPQAALDETKRILAALAA"
ORIGIN
        1 ggtgcgtctc gcacgggagc gaggttgggt atagtaggcc tcgcgccacg gcgcagcgcg
       61 gacgtagctc agttggtaga gcgcaacctt gccaaggttg aggtcgccag ttcgaacctg
      121 gtcgtccgct cgtgaaagaa ggccccggtc cactggaccg gggccttctt cgtcccgcta
      181 gctccaaccg atccccgtca gacgctcgta cgcctccacg tacttggcgc gggtcgcggc
      241 gacgatctcc tcgggcagcg gaggcggggg ctgctcgctc gcgcggtccc agccggaggc
      301 gtccgaggtc agccagtcgc ggacgaactg cttgtcgtag gactgctggg cgcggcccgg
      361 cttccacagg tcggccggcc agaaacggga cgagtccggg gtgaggacct cgtcggcgag
      421 gaccagggtg tcgccctcga agccgaactc gaacttggtg tcggccagga tgatgccccg
      481 gtcacgggcg atgtcccggg cgcggccgta cacggcgaga gtcgtctgac gcagctgggc
      541 ggcggtctca gcgccgacct ggcgggcgac ctcctcgtac gacacgttct cgtcgtgctc
      601 gccgacggcg gccttggtgg ccggggtgaa gatcggcgcc ggcagctccg agccgtcgac
      661 caggccctcg gggagggcga gaccgcagac cgtgcgggag tcgttgtact ccagcaggcc
      721 cgagccggtg aggtagccac gggccaccgc ctccaccggg accatcttca gcgacttgca
      781 gacgagcgtg cggcccgccc agtcggcggg ggcgcccggc gggagttcgg tgctcaggac
      841 gtggttcggg accaggtcgg cgagctggtc gaaccaccag agggacagct gcgtgaggac
      901 gcgccccttg tcggggatct ccgtgggcag cacccagtcg aacgcggacg ttcggtcgct
      961 ggcgaccatc acgaggtcgc ccgcctcgtt ctggtacagc tcgcgcacct tgccggtgtg
     1021 caggtgcacc aggcccggaa cctggatcgg ctcgggcttt tctacgaatc cggacacggt
     1081 tcctccccgt ggtgatgtcc aagtggctcg attctcccgt acgcgggcga ccgatcttgg
     1141 ccaggggttg tgttcggtgc gctcagtcgc gtttgcagat gcggtccagg aggtttgccg
     1201 tggctcgctg gacccgagtg tcgacgtggc ccggacggtc cagggccggg gaccacgcga
     1261 acgttccgga tgcgaagacc caggcgccgg agggggcgcg atacagcgag gtctcctggt
     1321 ggcggacgac ctcgtccttg tcccggtacg gggagtgggc gaggagcata cggccctggt
     1381 gctcggggag cggggtgcgc gggaagtagc ggtcggcctc gccggcgacc atgccggcca
     1441 gctcgtcgtt ctcatgggca ccggtcgcgt cccagagcca gtggtcggcg ttgcgcacga
     1501 ccagggggtg cggttcgggg acccggccct cgtactggat gcccatcaac tgctgctcgg
     1561 ggcggtcgac ttcgcgccac agtgcgggtt tgccggggcc ccggcgtttt cggcaggtga
     1621 ggaggcggtc gggggctccg gacggcgagg ggctcagctc cacctgccag tacatggtgt
     1681 tggaggagag gaagaccagc gaggtgccgc tgtcccgggc gagttcggtg gtgcggcgca
     1741 tctgcggcga ccagtactcg tcgtggcccg ggaagaccag cccccggtag cggctggggt
     1801 cgacgcggcc ggcgtgcagg tcgcgggcgt cggcgtaggc gagatcgtag ccgtagcgct
     1861 cggcccagcg gatgaagtcg taggcgtggc ccacatggag gggaaggccg gcgccggcgt
     1921 acgggcggtc gaaggagacg gtcgtcgcgg cctcggactc gccgagcagc cgcccgtcct
     1981 cgtcccaggc gtggtagagg ctggcgccgg tgcggccgtc ctccggatac aggttgtacg
     2041 cctgccaggt gatgtccggg agcaggagca gcaggtcggc cgggcggtcg tcgcggacgg
     2101 tgaacgggac gtgggagcgg tagccgtcgg cggtggtcag gaccgcgacg taggcgccga
     2161 cgttccagta gctggggatc tgcagccgcc aggagagcca ccagtggtgg caggagaccg
     2221 tgcggtcggc ggtgaggggc gggggctgga cgatgccgga cagccggggg ctggtggtga
     2281 tcttcgccgc gccgtcgccg ctgtagtggc cgatgcggta gatgtcgacg ccgaattcct
     2341 ggggcgggtc cacggtgacg tggaagtcga tggactggcc gggagcggcg gcgccggtcg
     2401 ccgcgaaccc cttgatctgc cggcgtacgt cgtcggcgga gcgggggccc ggcgggacgc
     2461 ggggggccgg gacacgggcg cgggtgcccc gggcggacgc ggggggctcg ggcgggcccg
     2521 ggtccacgta ccaggggacc acctggccgg tgtcgtcgaa gtacgtcaca ttgccccgca
     2581 gccaggggac cggtccctga ccgaaggggt ccgtcaccgc gtgggcgagg gctcccgatt
     2641 cccagcggcg gatgtggtgc tgctccgagc ccatgagttc tcccctccct cgcccccgtg
     2701 agctgtcgtg agcacgtgct ccgtacgcga cctgtcccag cacatcacat taagcacgca
     2761 ccccgtcacc gttcgtcgtg aatcggtggg agtggaacgg cgacgtccgg atagggagtc
     2821 ggacaccccc ttccgaccag ccacaacacc cccaggaccc tctgcgggat cggcctcggg
     2881 accaccgtcg ggcgggctcc ggaccaggcg ttcggaccag gcgttcagac caggcgttca
     2941 gaccaggcgg accggtttct ccgggcggac gccgaggcgg ctgagccagt cgcggagggg
     3001 gaccgggtcg ccgtcctcca cgagggtgag gacgcggggg gcgaggtcgg ccgcccgtac
     3061 gccgtcgacg aggagggagg ggccgtccag ccagtccagg cccggggtgg cgcccgccgt
     3121 gtccatcgcc gcgcagcaca ccatcgcggc gacgtgctcc gtcagcagct cgcggcccgt
     3181 gcggggtggc tgcatcggga acagcggcag cagtccgtcg tcccacagcg cccggtccgg
     3241 gccctgcgcc tcggccccac cggccgcggg gtggccgtcg gccgggaccg tggcctcctc
     3301 gcgcgccagt tccgcggtca gggcggcggc gagggcggcg gactgcgggg tggccaggcc
     3361 ggattcgtcg tcggagtcgg aatcgaggtc cgggcctggg gcagtggtga cgccggcgtc
     3421 gtgcggggat atgtggtggc tgtccggttc caggtcgggg ttgtgctcgt gttcgcggtc
     3481 cgcctccgcg gccgtcgcgc gtccggcggc ggggtggggg gacgggtggc cgtgcggcgc
     3541 ggtcgtcgta ccgggacccg ccccggggac ctcggcggcc tcggtggccg gcggatgcgg
     3601 agcggcggcg gccgcggtgg tcaggtgggt caggacccgg gagagggtgg ggccgccgtg
     3661 cgccgggccg gtggggtcgg tggtcgggtc gctcgccggg tggcggacgc ccagcccgtc
     3721 gaggacgcga tggagacggg ccgcgtcggc gcgccatttg cggtcgacca cctcgtccgg
     3781 gtactcgtgc cagtcgaccg gcgaccagtc ggggcctgac tcggcggggc cgccgtggaa
     3841 gaggcgggcg gcgagcaggg acgcggcctc gtcgaccgtg ccgggctctt cgagcaggtc
     3901 gcaggcgggg cgctcgccca gccgggaggc gaagccctcg gcgaggcggt ctcggcgcga
     3961 cagctccgtg agcgcggcca cgacacccgc gtccagacgg gacggccacc ggcccatccg
     4021 ccacgcgggc agcgcgaccc gggtgaggag acggtcccag cccgcgtagg cgaggccgac
     4081 ctgctcctgg gcgacgatcc gcagaccgta gtccacagcc tgtgcacgct cggccgccgc
     4141 ggcggcgacc ccgcgctcca tctcggccgc gtgcccccga cagccgcgca ggagcatccg
     4201 ggtcacccag ccgactccgc ccagcgccgt acggacggcc acaccgtgcg acggggccga
     4261 gctgacggcc acggccgcgt ccagcccccg cacgaaacgg cgggccgcgg ctatgtccgg
     4321 gtgcgccgac ggtcccgtac ccgcgacgac cggggccagc accgctcgta gctcaccgac
     4381 ccgcatccac cacaggaacg gcgagccgat gacgagcacc ggcgcggtgg gcgcgcggtg
     4441 ccgacggtgg gaggagagcc ctgactccgg tccggatgcc agacgggact gcggacggga
     4501 gggcaggccg ggtgacgagc cgcgcgtgtc cgtcatctcg tcgtcccgcc ccgtgccgcg
     4561 gtcaccggcc gtggcgcccc cgccgtcgac cacctcgctc ccgtcggccc cgtcgttcga
     4621 ggagtggcgg ggcgcgtcgg gctggtggtg ggacgggtgg gtgcggtcct ccagccagct
     4681 gtcgcagtcc ggggtgagcg ctatcgcgga cgggggcggg acgtcgaggc ggtcggccag
     4741 gtcccggacc agccggtaga gatcgggcgc ggccttctcg gtgaccgtga ccgtggggct
     4801 cacggcgggc cgggcacggg cgacgacgag cgcgatgccc gtggcggcga ggagcacgac
     4861 gagggcgagg ccggacacga tccggctcgc catggaccag ccggggccgg tcagacggcc
     4921 ggtcgacccg ccgaccacca ggacgacggc gacggccgcg ggcagcaccg ccacggccag
     4981 cgccctgctg cggacccgca gcacggcgag ggcccgggcg cgcgcggcct gcgcgcccgc
     5041 ctcctcacca cctgccatac cggtcacgac ccgacgtcac cccctgctgt cccgtgcggc
     5101 gcacaccgcg acgactgcga ggactgctcg tcgcagtggt cgccgccgaa tgccctgacg
     5161 ttgctcactc ccccactgtg gcaccgccca ccgacatcgc aatgccggtg ggccaagtgc
     5221 cggaacgctt gcgccgcacc ctagttgggg ccccggccgt cgtcagccgg ttgggccatc
     5281 gctcactcga tggaatggct ctggggagag gtgaaggacg ccgggcaagg atcgggcccc
     5341 ggattccgac ggcttcccag gggttcctgg gtgtctccga gggattccgg ggcctggggt
     5401 tcgtacccgt tgctgacgct tcgcatgcgg atgtcgcgaa ggggacggat gtgcagggag
     5461 gcgttgagga aggacgcggg ggcgtggagg ggcgggccgg tccacgcccg tcagtcggtc
     5521 acgcctccgc cgccgccttc gccgcgatgt ccgaccggtg ctgggagccg tcgaggccga
     5581 tgcgggcgac ggcggtgtag gcacggtcgc gggcctgggt gaggtcctca ccggtggccg
     5641 tgacggacag gacgcggccg ccggcgctga cgacctcgtc gcccacgcgc cgggtaccgg
     5701 cgtgcaggac gtacgcgtgc ggggcgtcca cggcggcgat ctcgtcgagg ccggtgatgg
     5761 ggtcgccggt gcgcggtgag ccggggtagt tgtgcgaggc cacgaccacg gtgacggccg
     5821 cgtcggcgct ccagcgcagg ggttcgaggt cgccgagggt gccgttggcg gcggccagca
     5881 ggacaccggc cagcggggtc ttgagacggg cgaggacgac ctgggtctcc gggtcgccga
     5941 accgcgcgtt gaactcgatc acccgcacgc ctcggccggt gatcgccagg cccgcgtaga
     6001 gcaggccgga gaacggggtg ccgcggcgcc gcatctcgtc gaccgtcggc tgcagcacgg
     6061 tctgcaggat ctcgtcgacc agcttcgggt cggcccacgg aagcggcgag tacgcgccca
     6121 tgccgccagt gttggggccc tcgtcgccgt cgagcgcccg cttgaagtcc tgcgcgggct
     6181 ggagcgggac gacgctcacg ccgtcggtga tggcgaagag ggagacctcg gggccgtcca
     6241 ggaactcctc gatgacgacc cggccgcacg cgagcgcgtg ctcgcgggcc tgggcgaggt
     6301 ccgccgtcac gacgacgccc ttgccggccg cgagcccgtc gtccttgacg acgtacggcg
     6361 caccgaacgc gtccagcgcc tcgtcgatct cctcggcggt ggtgcagacg tacgaccgcg
     6421 cggtcggcac gccggctccg gccatgacct ccttggcgaa ggccttggag ccctccagcc
     6481 gagcggcctc gccggacggg ccgaacaccg ggatgcccgc cgcgcgcacg gcgtcggcga
     6541 cacccgcgac cagcggggcc tccgggccga cgaccaccag gtcggcctcc agccgcgtgg
     6601 ccagcgcggt cacggcggcg ccgtccagcg cgtcgaccgg gtgcgactcg gcgacctccg
     6661 ccgtgcccgc gttgccgggt gcgcagtgga gtgcggtgac atcgggatcg agggacagcg
     6721 aacggcagag cgcgtgctca cgagcaccgc tgccaatgac gaggaccttc acggggtcag
     6781 cctagccgca gggggtgggg ggctttgtgg gggcgcccga agagtgggac ggggcgggtt
     6841 cgtctgatcg tacgaatcgg agcggcgaac gagggcccaa ggccctacgg cgacggtccc
     6901 cgcccgcggc tcgcccgcta ctcgttcgtg atctcctcca ccacggtcgc ccccagttcg
     6961 cgcacgatca gttcgtggcc ggagagggcg gactcgtcga ggtcggggtc gtcgtcctcg
     7021 ggggtgtcgt cctcggggga gacgggcggg ggctcagggg gcgagggcgg ggcggctgcg
     7081 acgggagggg cggccggggc cgaccgaggg ggcgcggccg gaccgggcga cgcggggcgg
     7141 gcggccgtcg aggacggggg agaggcgggg cggggcgcgg gggccgggga gccgccgtac
     7201 ccaccgccgg cgccgccacc gccgtagccg ccgcccgtac cgccaccgcc gtagccaccg
     7261 gcggccggcg ccggggaccc gtagccgccg ggggcgaccg gtgcggcgga gccgcccgag
     7321 gtgtcgatga ccgcctcgat cttccagtgc acgttgaact gctcggccag tgccgcccgc
     7381 aggacgtcct cgctgccgct gctcgcgaag ttgtcacggg cgcccgcgtt gacgaagccg
     7441 atctgcaggg tcgtgccgtc gaacccggtg acgtgcgcgt tctggctgag caggatccag
     7501 gtgaagcggc ggcggttctt caccgtctcc aggatgttcg gccagagcgt gcgggggtcg
     7561 ggtccgccgg gggccgggtt gtgggcggcg ggggcctggg gggccgtagg ggcgctcggc
     7621 tgggcgtacg cggcggacgg gcccgcggcg gggggcgcgg ccggggctgc gggcgcgggg
     7681 ccggggccac cgccggcggg cgcggccgtc ggccatccgc cgggacggcg cccgccgccc
     7741 gcggaggcgn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnggtc cgggcccgat
     7801 gcgcctgtcg cgcccgcggc cccccgcgcc gccgcgcgag ctgcggcggg cccgccaccc
     7861 ggtgggacct gctcggtctg cggggcgtgg gcgggcggtc cggcctgcgg cgtcacgccc
     7921 gtgcccaggg gcggggcggc cgctcccccg tgcgcctcgg ggccgggcac gtaccccagg
     7981 gcgggaccgg caccgccgcc cgcgaagttg atcccgcgct ccaggcggtc caggcgggcc
     8041 atgacggagc gttcgtcgcc gtaggtggcg gggaggagca cgcgggcgca gatcagttcg
     8101 agctggaggc gaggcgagtt ggcgccgcgc atctcggtga ggccttcgtt gaccaggtcg
     8161 gcggcgcggc tgagctcggc ggcgccgaag acgccggcct gggcctgcat ccgctccagc
     8221 acctcgacgg gggcgtcgat gaggcccttc tcgacggcgt ccggcacggc ggccaggatc
     8281 accaggtcgc gcaggcgctc cagcaggtcg gcgacgaacc gccgcgggtc gttgccggcc
     8341 tcgatgacat ggtcgacgac gtcgaaggcc gcggccccgt ccccggcggc gaaggcctcg
     8401 acgaccgagt cgagcaacga gccgtcggtg tatccgagca gcgacgtggc catggcgtag
     8461 gtcacgccct cgtccgtcgc gcccgccagc agctggtcca tgacggacat cgagtcacgc
     8521 acggagccgg ccccggcgcg cacgacgagg gggaggacac cctcgtcgac cgggatcttc
     8581 tccttgccgc agacctcgcc gagatactcc cggagcgtgc cggggggcac cagccggaac
     8641 ggatagtggt gcgtacgcga gcggatcgtg ccgatgacct tctcgggctc ggtggtcgcg
     8701 aagatgaact tgaggtgctc cggcggctcc tcgacgacct tcagcagcgc gttgaaaccg
     8761 gccgacgtga ccatgtgggc ctcgtcgatg atgtagatct tgtaccggct gctcgcgggg
     8821 ccgaagaagg ccttctcgcg cagctcacgg gcgtcgtcca caccaccgtg agaggccgcg
     8881 tcgatctcga tgacgtcgat cgaacccggt ccgttccgcg ccaggtcctg gcacgactgg
     8941 cactctccgc acggtgtcgg cgtgggcccc tgctcgcagt tcagacagcg ggcgaggatg
     9001 cgcgcactgg tcgtcttccc gcagccgcgc ggcccgctga acaggtacgc gtgattgacc
     9061 cggttgttcc gcagcgcctg ctgcagcggg tcggtgacat gctcctgccc gatgacctcg
     9121 gcgaacgact ccgggcgata gcggcggtac agcgcgagag acgacacgct tacgaggtta
     9181 taggcgccca ctgacaacac ggacaccgcc ggaggagacc aggccggaag gggcgggagt
     9241 catcgaccgc gaggacggag atcgccggcg gcgccggtcg ggcgggatgc cggagcccgg
     9301 ggcgggagcc cgggggcggg agcccggggc gggccgcctc cggacgcaga agacccctca
     9361 cgcacccgcc agagccaacc tacccttgct gccttccggc cctgggggag ttcagtcaga
     9421 tagcgccgcg tgaggggctg cccccaccct acccgatcca cgacgcccgc cgtcccgcct
     9481 cccggcccct ccccccgcct cgatcacccg gccgatcgcc cgccctcgaa cgagttcgca
     9541 accaccctcc gacgtcatgt aatgttcccg gcggaggatt cgcctagagg cctagggcgc
     9601 acgcttggaa agcgtgttgg gggcaacccc tcacgagttc gaatctcgta tcctccgcca
     9661 ttgctctcac cgggcaatac gtcgaagggc cccaccgctt gcggtggggc ccttcgacgt
     9721 tgtccgtccc ggtctccgtc tcagtcgagg tgggtgatgt ccgtccagtg ccaggcctgg
     9781 agggacgggt cggtgaagat gcggttcagg gtgtggttca ggtccgggat tggggtcggt
     9841 cgggaggggt ggctgaggcg gacggtgaag cgggtgccct tgacgtgggg ttcgtagtgc
     9901 cagtcctcgg ggagcagggc caggaaccgt acggcggcca gttccggggc gccggccgcc
     9961 tcggtggggc ggggttcgat caggactacg cggtggtccg tcatgagagg aacggcaggc
    10021 cttcgcccga gccgagtgcg tcgtcgaggg cgagcaggac gcctgccgtg ccggtggcga
    10081 ggtcggtgga gaggcgcagg gtctggtcgc cgaggaaggc ggggtggccc gcgtagggga
    10141 tggcgtgcca gccgaaggcc gtgagatggc ggtgcaccgc ggcctcggtc tccggacccg
    10201 gcgttctgcc gtgcagtcgg cgcagggcca gcgtcgctcc cgcccggccc tggaacaggc
    10261 ccgcctgggc ctggtagggg gaggccagcg aggagtggag gagggggagg gcgtcgtgca
    10321 gggccgggtc cggggagggc aggtgcgcca gtacgtcgct cacgaccatc gccgttcccg
    10381 cgccgcccac cgccaggtac ggcatccggc tgatgcccgg tccggtcgac agctcggcga
    10441 ggtcgtggcg cagtccctcc accgccgtgt gcagcagttt cgggtcgccc gtcctctcgt
    10501 acagccgcag caggaacagc gccgcgcccg tcgcgccgtg gagcagaccc ggtcgggggc
    10561 gggccgcgta gccgcccggg gtgcggtcag cgaccagttc cgccaggcgt tcggccgcgt
    10621 cgaggtggcc gaagtggagc agggagaggc cgatgccggg gaggccggcg aagagggagc
    10681 cgtccacgtc gtccagcggc agggcgaggg cgcggtccag gacctcgtgt gcctcgaccg
    10741 tacggcccag ggcgtcgagg gcgtaggcga tgccgtgcag gccgtcgtag aagccggggc
    10801 ggggttcggt ccagcggcgg acgcgctcgg tcagccagtc ggtgtgcgcg gccgggatct
    10861 ccgtaccggc gccgcccagg gcccacagga ccccggcggc tccgtgggcg agggcgaggc
    10921 cgccgcccgg ggtggtgaac tgggcgatgt cgccggggaa gaggcggtcc tcgcggtccg
    10981 gggtcgcggt ggccaggatt cccgccgcga gtgaggcgcg cagggacgac cagtcggcgg
    11041 gggtgagggt gtcgggccag acgggggccg gggcggcggc gctcgcggcg gtctccgcgt
    11101 gcgcggcggt ccccgcgtgc gcgtcggtcc ccgctccctt tccctcggcg gtgtcgtggg
    11161 cggccgtcag atccgccacc acccgctccg cgaagtccgc cggcaccggg aagttctccg
    11221 tcaccagggt gatcagttgc tccgtcttct ccgggcccca gttcagcacc accgtcagcg
    11281 gcaggaacac cgcgaggcgg aggcagccga gggcgtagcg gtcgaccgcc gggcccgtgc
    11341 agccggccgg ggcgcggaag ccgggtgcgc cgatcgactg ggcggccatg gcgtcgaccg
    11401 gggtcgccgt ctccaggtcg atgaaggcga tcgagtcgtc cggccggacc aggacgttgt
    11461 tggggtgcag atcgccgaag accacgcccc ggtcgtgcat ggcccgcacg cccgcgtcga
    11521 tctggtcgag gagggacagg gcccaggagg tgtacgccgt gaacgactcg gaggaggcgt
    11581 cggcatccgg gttcagcagc gggttggact cgtggatacg cgtgtggagc gaggcgcccg
    11641 gcacgaactc ccgtgccagg aagtagtgtt cgcgcccctt gcggtagtcg atcagcggcg
    11701 gcacgcagtc cagtcccgcc agccgctcca gcgcccagcg ctcgcgctcc agccgggtca
    11761 ccgcgtcctc gccctcctcg tcgaggccgg ccagcgggcg agcctccttg aggagcacgg
    11821 tggcttcggt accggagccc tggcgcaggt cctgggcctc gtagacgccg ccaccgttgg
    11881 agaagtgcag cgccctgacc gcgcggaacg ggaagtcgcc catcgtgctc gcgttacggg
    11941 ccgccagtga ctcggcgagg cagtccggca gcgtcaccca cgcgggcggg cggaagccgg
    12001 ggccgcgtac gtcggggacg agacggccgt ccgggtcctc gatgcagtgc accgggtcgc
    12061 ccttcgcgtc ccggccgagg cgggcgacga agccgccgta gcggacgtag agcgggccgg
    12121 agcgccagcg caggtcgctg aggatgtacg ggcccggctc gccgccgacc tcggcgtcca
    12181 ggtcgacgag cacccgctcc agctggggct cgtccggcgg gtagacggtg atgaacttgc
    12241 cgctcgcgcc gcggtcgccg tacttgctgt tgcgccggtt caggacctcg gcgctgcgga
    12301 tgtacttgaa ggtgaggcgc tcgcgtacgc agtaggcgcg tacggcggcg aggacgcggt
    12361 cggcgttgtc ccgggtcgcc gagacgtgga tcttccagcc ctggccgggg agttcggtgt
    12421 gcggcggggt cagcaccacc cagtcggcgt tgacggtgcg ggtccagccg gcgggggcct
    12481 gtgccaccgc gtcggcgggt tcggtggggg cggtggcggt cgccgggtcc tcgtagaacg
    12541 cgttgcccgc ctggcagtag gtcacgtacc ggagatccat ggtcgttctt cctgtgaggg
    12601 ctctgggcta ccagcgccag gccggtgcga cgtacttggt gtagagccac tcccagcccg
    12661 ggcggctgcc cgcgtccagc tgggccgcgc ccgaggggtc ggcgggggca cggtcacggc
    12721 cgccgcgcag gtccagcgga aggccgaggg ccggggtcgg cagggcgtcg ctgcggaccg
    12781 ggatcagcgc cgacagcggg gccatggcgt ccttgccgtc ggccccgtcg acggcgaccg
    12841 tcgcggcgcc ggtccgggta cgggtcgcga tgccggcgcg gtagaggcgt accggggcgc
    12901 cggaggtgat cagcgcgcgg tcggtggact ggggcaggag cagcgtgacg cggccgtcct
    12961 cggccgtcgt gtagccgccg ttgacggtgt aggggacctg gaccagctgc ccgagcacgg
    13021 cgagggcggc cgcggccagg gcgagcaccg cgccgaggcg ccaggggctg ccgcccgccg
    13081 tccgggcctc gcgggcgaag cggcgtacgc ctcgcgccag gtggtggagg aagtagccga
    13141 tgccgcacag gacgaggagc gcgcccaggg cgccgaggcg ctggaggctg tccgaccaga
    13201 gggtgatcgc gcccgccacg atgtagagcg ggaaggtcat gcagagcaaa ccgaagggaa
    13261 ccgcccagcg cacgccgggc agttcgcggc ggtagccggt gccgccggcc agcatccggg
    13321 ccagccacct gcgggcgtcg gtcatcgccc ggtcgcgcag atgcgggatg tccaggtggc
    13381 tcatcagcgc gatgtagccg tccagtttca cgaacggcag gaggttgagc acgccggaga
    13441 ggtaggtgac gacggcatac acgagaacac cgtcacgcgc cgccgaggcg cccatgaaga
    13501 gggtggcgag ggcggcggcc ccggcgatga cggtctgggt ggcgatgccg gcgagggcga
    13561 cccgtacccg ctgctccttg cgcggcagcc gccagccgtc ggacacgtcg cagaagaagg
    13621 ccggcgacat gtagaagagc atcatgccca tccgggtcgg ccgtccgccg tagtacgtga
    13681 ggaccgcgcc gtggccgatc tcgtggacgg cggtggtggc gagcaccgcg ccgatcacgc
    13741 agaggtagag caaaggtgcg aaggggcgcc ccaacgcgcc ctggaggtcg gccccttgga
    13801 aggccaggac gagcagtccg ccgatcgtga cggccgaggc ggcgacggcg gccccgcggt
    13861 gcgcggcggc cgccacgagc ggggcgaggc gggccagcag ccggtccggc ttgaggaggg
    13921 tgaactgcag ggtgagcggc gggacgaagc ggaaccagga actgcggtcc ttcttcggca
    13981 ctccgtcgtc cagcaccttc gccccggcga gtgtccgcac cgccgagccg acgtcggcct
    14041 gggtccaggg tgcgccgagg gcgtcggcca ggtcgtcgtg gtcgcgtacg ccgtcgacgg
    14101 cccggacgag gcgggccagg tcctcctgga ggcggaagta ctggtggctg ccgcgctgca
    14161 ccacccaggg cgcgcccggc tcggccggct cgtggaccac cacgtcgggg gcgaggcggg
    14221 gacgggccag ccgctcgggg gccagtagta cggcaccggc gggtgtgctg gacatgcctg
    14281 gttctctcct cgggacggcg ggacggcggg gtggcggggg tggattcggt ggctccgcga
    14341 gcgccggtgt cggggcatgc cgccgggcga cgtcgcgggt ggtgtcggac gcgacgtcgg
    14401 acggcgggcg acatgacgtg gagtcaggtg acgtggggtg aggtgaggcc gggtgaggtg
    14461 aggccggggc gggggcccgt acggcgacgg ccggcgctgt cgtcagacga cgtcgcgcgc
    14521 ggtgaacagc ttccgggcga gcagcgcggc ggccgtcagc cagcccacga tcaccagcag
    14581 cgcgagcggc gtggagagca ggtcgggctt ctggtcccgg tagacggaac tctgggcgat
    14641 cgtcatcagg tacttgccgg cctccggcac cagcacctgc accgccgggt cgacgaccag
    14701 ggtcagcgcg acgacggtca ccacggcccc cacctggtgc cggacgatcc agccgaccag
    14761 cgcgccccag ggtgcggcga gcgtgttgac ggcgaagacg cccagcagga tcagccaggt
    14821 ctcgccgtgc cacgcgggct tcgtcccgtt ggccgcgagg gtgccccagg cggaggcgag
    14881 ggacagtgcg gcggtgagca gcgcggcgag ggcgcccacg gcggtggcgg tcagcacctt
    14941 ggcggcgagc agacgggtac ggccgccgct catcaggacg gagcggccga tggcacccga
    15001 ggtgtactcg cgggagacga agaccgcgcc gaagagggag gtgaagaggg acatcatgaa
    15061 ccaggagcgg acgatgtcgt cggtgacggc cgcccggccc atggtgccct cctcgatggc
    15121 cgtcaccccc tgggaggcgt aaccgagggc accgagcagg gacatcagga caccgcaccc
    15181 ggccaggatc agccagccgc ggccggtcca ggccttggtc cattcgccgg cgagcaggtt
    15241 acgcatggct ctgtcctccg acagcgaatg aggcggccgg cacggttgat acggccggtg
    15301 cggttgatgc cgtcgtcggc gagccgacca gggagaagaa cctgtcttcg aggcgttccc
    15361 cctcgcccgt gccgacgaga ccatcgagcg gaccggcgta ccgcagcgag ctctggatga
    15421 tcaccacgtc gtccacggtc tgctccacct cggagagcag gtggctggag acgaggacgg
    15481 tcctgccctc gtcggccagg ccgcgcagca ggccgcgcag ccagcggatg ccgtccgggt
    15541 cgagaccgtt ggcgggctcg tccaggacga ggagttcggg gtcggggagc agcgcggtgg
    15601 cgagcgcgag acgctgcttc atgccggtcg agtagccctt gacggggcgg gaggccgcgt
    15661 tgccgtcggc caggcccacc aggtcgagga cctcctcgac gcgctgccgg ggcaggccca
    15721 gggtccgggc ccagatggtg agttcgcgtc gggcactggc gccgggcagc ggccccacgg
    15781 cgtccatgct gacgcccacc cggcgggcgg cgtggggcag ttcggcgtag gggcggccga
    15841 agacggtcgc ttcgccggag gtcggccggc acaggccgag cagcatccgc agcgaggtgg
    15901 tcttaccggc tccgttgcgg ccgaggaggc cgacgatccg gcccggccgg acctcgtacg
    15961 tcaggtcgtc gaccgccgtg acctcgccga agcgcttggt caggccgcgc agggcgacga
    16021 cgggcgcgcc ggcggtgctc gacgggttcg cggtgctcaa cggcgtgcct tccggaggtt
    16081 ggcgccgatc ttgaccaggc agctcagcat gacggcaccc aggccggcca tgacgaagat
    16141 ctcgacgcca cccgacagct gcgaggtggc gacggccatg ccgagcggga tgagagcgca
    16201 ggcgaaggcg aggttcttgt tctcggccgc tgccttgtct cggctgttgg ccatgctgga
    16261 ctccttggtc gcactggtgg gacttgggtg gggggagggg gcggagaacg aagcgcggat
    16321 tccgcggtgg cggcccaggg ccctctgcgg gcccgggacg ccgccgcgga aatccgtatg
    16381 cggttcggcc accgctgccg gctgatcggc cggatcaggc agaccgccgc ttcagacaga
    16441 ccgccgcttc agacagaccg ccgcttcagg cagaccgccg gatcggacag acctgccagg
    16501 tgggacagac ctaccggatc aggatcaggt ggcgatgacc gcgctggcga cggtgctgat
    16561 cacgacgccg gtcttgaagc cgctccagaa gcccggggcc tccatggcct ccagctcctg
    16621 catgcccagc tccagcgacg cgtcgaagcc ggtcggctcc tgcgtgacgt tgtccttcat
    16681 atcggtttcc ctcccgttga gttgagactg gatcgagtcg aacgagtctt gagtggatca
    16741 ggtgatgatc gagacggcga cgcccgtcga gacaccgacg gccgacacga ccgtcgcacc
    16801 gacgacgacg ccaccggcgg tccaccagcc cggggcctcc atggcctcaa gctcctgcat
    16861 gcccagttcc agggcggagc tgaagttgtc gttctcgaag ttctcctgca tgggaactcc
    16921 cccttttctc atggtgtcga gagccgttgc tctctttccg cccgctcccg ggaccgggag
    16981 cggaagtctc agatgtgcgc ggtgagcgcg gcgtgcgcgg tcggcgcggc gtgcgcggtc
    17041 cgtgtcgggg tcgtgccgag cgccgcgtcc aggaggcggc gtacgtcctc cgcccgcagc
    17101 ccgccgagca tcggcaggcc ggcaccccag gcccgtacgg tccgctcggc cagggcctcg
    17161 atccgtcccg gcccttcggc ggtgagccgc cggcccaccc gccagtcgtc catcagggcg
    17221 gcgatcccgt cggccgggtc ctcgggcagg gcccgccccc ggtccgccga cgcggcctcg
    17281 cgcagcccgg cccacatccg tcgcagccgt ggcgcggagc ccagccgggg ctccccgtcg
    17341 agcacggccc gccacaggtg cggcagcagc gcggcgacgg cggtcatctt ccgtacgccg
    17401 agtgccgacg acatctcgtt ggcgatgagc cagcccttga ccgcgtacgg gtcgcggccc
    17461 tggtgcagcc actcgccgtg cgtgagcccg ctgagcttgg cgatgtccag gcggagcgcg
    17521 tcgccgggct cctcctcccg taccgcctcg tagccgagct ggacgagccg ccgggcgacc
    17581 gtctccgtca gccggtcctc ggtgcggcgg tcctcccgat ggtcaccggc gtacgggctg
    17641 accgcccgga acagcgcctc caggacgccc tccacgacca gttcccgggg cagtgtcacg
    17701 gtggccgacg gatcgagcag tgccgcctcc ggccgcagta cgccgccgag gatcagccgc
    17761 ttgccctgcg ggtacgcgag gcaggcgacc gcgctcatct cgctgccggt gccgagggtc
    17821 gtcggtacgg cgagcagcgg gacggtacgg gtgacctcgc ccggcaggcc catcaggccg
    17881 ccgcgctggg gcacggtgag gcgggtgtac gcgaccgggt tggcccgcag cagggccgcg
    17941 atcttcgcca ggtcgagcac cgatccgccg ccgacggcga ccaccaggcc gacctcggcc
    18001 tcctcgtccg ccaggctctc ggcgagcgcg gcggccgcgt cgagatcacc ggggccggcg
    18061 gccagtggtg tccgggccgt ccgccagcgg gcccggccga ggcggtcctg gaccagggcc
    18121 gtgatccccg ccgtcgcgac agcggtgtcc acgaggaggg cggccgtgcg gcctcctccg
    18181 tcgggaagcc atgccgtgag ggcgtcggga ccgatcagcg cccgggtcgg tccgcctcgg
    18241 ccgtggctca tgccgctacc tccgcctgga ccgagtcgct ggtgaacagg tcggtgaaca
    18301 gggccagtcc ggcgcggatg cggtccgtca gttcggtcag gtccgcgtcg gtgtaggtca
    18361 gcgcggggaa gagctggatg ccgtggacgc cggggtgcac gatggcgccc gccgtacgga
    18421 tcgcggcgac cagctccggg acgcgggcct gcggcagcgg ttccccgtcc ggggtggtca
    18481 gccgcagtga ccggaaacag cccacaccgg tggtgcccgt cacccagggg tgctcgtcga
    18541 ccagccgggt cagctccgcg tccagccgga gcgccagggc ccggccgagg gcgaccgcgt
    18601 ccaggcggcg catctcggcg atggtggcca ggatgacggc gcaggtgacg ggggtgccgg
    18661 cctgggtctc gccgtgggtc agcatggcgc ccgccgtgtc gaaggcgtcc gcgaccgtgt
    18721 gcgaggcgat gacggcggcg gcggcgccgg tgccgttggt gagccccttg gaggtcacca
    18781 ggaggtcggg ccgggcggac cagcgctggg aggcgaagaa gtcgccggta cggccgaagc
    18841 cggtggccac ctcgtcggcg accagcagga agccgtactc gtcgcgcagc cgcagcagct
    18901 cgtcgacgta ctcctcggtg agcggcaccg cccccgagcc gagcaccggc tcgacgacga
    18961 cggccgcgac catcggcccc tgacgttcca tcagggtgcg gatgccgacc ggatcgttgg
    19021 ggtcgacatg gcggatgagg cgctggtcga cgccgtacac ctgctgcccg aggtcctcgc
    19081 cggtcagcgc gaaactgccg tacgtcagac cgtggtagct gccgcgcagc ccgaccacga
    19141 gtctgcggcg gtcctcgccg cgcagggcgt ggtagtggcg ggcgagcttc atgacgaggt
    19201 cgttggcggc gccgccggag gtggagaaga ggacccggcc gtaggtgtcg gcgccgcaca
    19261 gctcgacgag ggcggcggcc gcggcacggg cgtaggagtt ctcgtagcgg aagacgctca
    19321 ggtacgaggc gtcgcggagc gcgtcggcgg cggcccgggc gatggcctcg ttgccgtagc
    19381 cgatgttggt gttccacaac ccgctggagg cgtcgaggag ttcgctgccg tcggcgtacc
    19441 ggacccgtac tccgtgcgcg gagaccgcgc agagcgcgtc cgagccgtgc agggcggggg
    19501 ccaggaggga cggccacagc gcgttcttgg tggtgccggg actcatgatg tgacctccgt
    19561 ttcgagcagt acgtcgtggt ggcgggagcc gacggccggc agggggtgcc gggcgcggac
    19621 ggtgagtccg gcggcggcca gttcggcttc gaggagggcg gcgggcagaa cgccgacgct
    19681 ggtcgtggtg acctggacgg ggctgtcgtc gtccgggatc cgtgccggga agacggtgac
    19741 cgtgcgggcg ctgtcgccga ccgcccagtg ttcgaacatc cggtaggcgc ggccggcttc
    19801 ggcctccacc accagttcgg cttcggcggg ctgaccggag tcggtgtcca tgccgacggt
    19861 cgacaggagg aaccggccgc cgggcgccag gtgtcggcgt acggcccggt acagaccggt
    19921 ccggccgcgc tcgtcgagga gcgagacgga ggtggtgccg aggacgatca ccgggaaggt
    19981 acgaccgagc gcgaaggcgc tcatgtcggc ctcgacgacc gtgcagcgct cgcgcagggc
    20041 ggcgggcgcg gcggccagcc ggtcctccag cagccgcagc atgtacgggg agaggtcgag
    20101 ggcggtgacc cggcggccca gcgcgagcag cggcatggtc agccgcccgg agccggccgc
    20161 caggtcgagg acgtcgccgg gcagggtccg cacgaggccg gtcagttccc gcacctcgtg
    20221 ggtgctgcgg ccggccacgt cgtggtagac ctgcgcgccc gcttcggcgt agaggtcgcc
    20281 ggtgacggca cgggagccga gccgggcgag cagttccccg gcccgtcccg ggatggtcgt
    20341 gggggcggtc ggtgacgtcg gagcggtcgt ggtcgtcagg gtggtggtca tcgtggtgtc
    20401 acactccggc ccgggcgagg aaccgctcga tgcgtacggt gtggtccgga tcggcgtacc
    20461 gcgccgccgc ctcggccgaa ccgcaggcca gcagcgcctc gaccggcgtg gccgccgacc
    20521 gttccacgct gaaggtgcgg ccgggggcag gggcgtgcac gtacacgtcc tggtcggtcc
    20581 acagcaggag cggcgcgtcc gcgtcccgca gatcggcgtc ggcgtcggtg gccagcgcct
    20641 cggtgatccg cccgccgaag ccggagaccc ggatggtgcc gtccactccg cgggccctca
    20701 gggagcggat cgcggcgagg gcggccaggt agcgcccgag ccagggccgg gcggccagcg
    20761 cggtacgccg caggtcgtgg tccacgaccg tccccaggca caccacgcac gtcgtctctg
    20821 tgccgctgtg gagccgccgc caccgcgcgt cgaggaggtc gggtccgtcg cccgccgttc
    20881 cgaggcgggt accgcccggc gcggtggaga cggctccgtc cgcgccgacg tacagccggt
    20941 gccggggtcc ggcggccggt gtgcggccgg cgccgaggcc cgggaggtcg gcgagctgga
    21001 tggcgggatg ggtgaggaag tcggggaagg tgccgtcgag cagggcccgg tcggcgtcgg
    21061 cgaggaagac gtcgaagtcc gtgtcgtcgg cgatccggac gagggtcggc ccggcgacgg
    21121 acatgtactc gctgatgccg taaccctgga tctggaggta gaagcccgcg cccggggaga
    21181 actccccgcc ggccccggcc agcgacccct cgtacccgac gacgcggtgg ccgtcggccc
    21241 cgctctcctc accgggtcct tcggagtcac cgggcccacc gggcacgagg accagcgtgt
    21301 ccgctccgac gacaccggaa tgcaggatcg ccgtcaggtg ctcgcggtct tccagtacga
    21361 cggtttccac gccggcgtac ggcaattcac cgattcgcgt tccggtttct gttccggttt
    21421 ctgttccggt gccgcttccg atatttgttc cgggtccggt tccggttttt gttccgattc
    21481 cggttccgat ttccgttccg gcgccggcac tggacgtacc ggtcccccag cgaatgagcc
    21541 gctctttcag atcagccatt ttctcgtctt cccccacggt caggcggcca gggcggccag
    21601 aatgcgcttc gtttcgtcca gggccgcttg tgggccgtac agattgcaga cgccggtcag
    21661 gttcaggacg acctcgtcca cccccgcagc gtcgaacgcg cccagtttcg cgacgagttc
    21721 gtccgggtcg ccgctgagga acgctccgcc gtcgacgagc gccttggcgt tcgccgccgg
    21781 gtcgtcgccg gcgacatccg tgccggaccg gcgcagcatg tcgatgtagt gggcgccctg
    21841 gagatgcgcg gcgttgctcg cgagcgccag ttcggcgggt tcgcggtcgg gccgggccag
    21901 ggcgagtggc acgatggcgg tgagtctcgg gggcgtgcgc cccgcgcctc ccttggcgtc
    21961 cggcgcgttc gccgcgccct cgcgcatcgc cgggagcacg gtgtcccgca ggtagtgcgc
    22021 cggagtcagc caggtcacgg ccacatcggc gacctcaccc gcgagccgcg ccataccggg
    22081 ccgcagcaca ccgagcccga tctccacacc cggcaccggg tagcggggca tctcggcccg
    22141 gcagctgaag tactcgcccc ggatgtcgac gctctcgccc gccagcagtc cgcgcacgat
    22201 cgagaggtac tcgcgtgccg ccgtgagcgg actgcggtac gcctcgccga gcagcgaccg
    22261 ctgcaacggc cggcccccgg gcccgaatcc ggcgatcacc ggctgcccgg tggccatcgc
    22321 cagcgagcgg gcctgcagag cggcttcgta ggggtggcgc agcggcatga gtgtgacgcc
    22381 gagtccggtc ggcacgcgga atcccgcccc cgccgccgcc acgaatccct ggtgcggctc
    22441 gatcatcacg gactgcccct gccagaggcg gctcgcgttg ctccagtgca ccagtccggc
    22501 gtacggaagg atctgctccg gccggcgcgg agggaagggc aggagtacgg aataagaagt
    22561 catggcctgt cccccctttc
//
