LOCUS       NZ_KQ257849            22586 bp    DNA     linear   CON 02-JAN-2025
DEFINITION  Streptomyces stelliscabiei strain P3825 scf_652_22.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ257849
VERSION     NZ_KQ257849.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces stelliscabiei
  ORGANISM  Streptomyces stelliscabiei
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 105220)
  AUTHORS   Harrison,J., Sapp,M., Thwaites,R. and Studholme,D.J.
  TITLE     Genome sequencing of plant-pathogenic Streptomyces species
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 105220)
  AUTHORS   Harrison,J., Sapp,M., Thwaites,R. and Studholme,D.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JUL-2014) Biosciences, University of Exeter, Geoffrey
            Pope Building, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.10
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001189035.1-RS_2025_01_02
            Annotation Date                   :: 01/02/2025 01:49:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,536
            CDSs (total)                      :: 9,455
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 81
            rRNAs                             :: 4, 2, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 2, 1, 3 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 482
            CDSs (without protein)            :: 482
            Pseudo Genes (ambiguous residues) :: 0 of 482
            Pseudo Genes (frameshifted)       :: 129 of 482
            Pseudo Genes (incomplete)         :: 407 of 482
            Pseudo Genes (internal stop)      :: 20 of 482
            Pseudo Genes (multiple problems)  :: 69 of 482
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:19:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 72984
            Orig. end                         :: 95570
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ257849.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22586
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="2"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..22586
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22586
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10000:12586](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12586
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            829..1995
                     /locus_tag="IQ64_RS03950"
                     /old_locus_tag="IQ64_04115"
     CDS             829..1995
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475245.1"
                     /locus_tag="IQ64_RS03950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04115"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_050398135.1"
                     /transl_table=11
                     /translation="MHHRTKTAAGARGARCAATALLTVTTVLLAGCERGSSSDPETSAS
                     GPNGCPKVHAEARAAVGRAERTDIPWNGPTSGPEAVTGRTIVYVAQTMTNPGVAGAADG
                     VRQAARAIGWNVRVVDGGGTPAGIQAAMSEAVTLRPSGIVVGGFDPGATSQQIARAERA
                     GIPVIGWHAVAAPGPSRRPALFTNITTQVEDVARISAQWVVSTSDGDAGVVILTDASIP
                     FAKNKSDLIRAELATCAGVKLLSYVNIPIPDASSRTPREVASLLSRFQDRWTHSVAIND
                     LYFADAAPAFRAAGKDGSGPPFNIGAGDGDPSAFQRVDSGQYQAATVPEPLTLQGWQIV
                     DEFNRAFSGRPASGYVAPVHISTADNSEGATSWDPSGYREGYRKIWGR"
     gene            complement(2075..3304)
                     /locus_tag="IQ64_RS03955"
                     /old_locus_tag="IQ64_04120"
     CDS             complement(2075..3304)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118159.1"
                     /locus_tag="IQ64_RS03955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04120"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_046912912.1"
                     /transl_table=11
                     /translation="MREPHIDYAEVFRALPGMVALLTPDLVYVDANDDFLRLAGRSREQ
                     LLGRYIFDVFPENPNEPAAAGMRETRESMLRAVVTGERDTMALLRYDIEDAERPGSWQE
                     HYWSPVNAPVIGPDGKVALIVHRVEEVTELIRARGGPGGDGRAQVLEAELYTRARELQE
                     VNERLRTAHAHEREVALALQAAMLPPPGPTGQHDAAVRYRPAIGALNVCGDWYDLVGLP
                     GEGLAVAVGDVVGHGLAAACAMGQLRSALSGATRLSDGPAQALEALDLYARSVEGAEST
                     TVVTTFIDWDSHTITYSCAGHPPPALMHPDGTVTFLDHATDPPLAARPTHAARPEACTS
                     FVENSTLVLYTDGLIERRTEAIDTGLRRLADSLTHHRKHDPETLADALLADLLPPSGNT
                     DDTALIVLRL"
     gene            complement(3686..5182)
                     /locus_tag="IQ64_RS03960"
                     /old_locus_tag="IQ64_04125"
     CDS             complement(3686..5182)
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005327.1"
                     /locus_tag="IQ64_RS03960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04125"
                     /product="FAD-binding protein"
                     /protein_id="WP_046912915.1"
                     /transl_table=11
                     /translation="MSHKEHSALNRRQFLARFGAGTVALVAGFDLIARQWVPEAAAAEN
                     SAFATVPPLDGTLVFDAASLAANAHDQGNIVFLRPCAVLRPGSVQDIRKMVGFCADHGI
                     EVAPAGAHHAMFGQPLVSGGLVIEMRSLDTIHSIGTDGADVDAGVLWQDLIAAAYERGL
                     TPASITSYLGTTVGGTLSMGGIGMMSAYRAGAQVDHADQLQVVTGDGRLRWCSDTQNTD
                     LFEAALAGLGQCGVITRATVDLVPAKQLARTYRIGYPDIPTFFRDVRVLANRGEFDSLG
                     SIPQPGTAQPLTLWATVFHNPGDAPDTSHLLRGLSPAAATAAFEDSPYLDYISLVTTMY
                     DSFAANLDWDAKVKPWSDLFLPDDAVEEYVASVFSSLTAEDLGPTGFGLVFPMLRSSYR
                     RPLLRLPSDAGGPWVWLVSVLTDAARSGPDPDFAARMMDRNYRFYQDAAAVGGVRYPHG
                     ACAFTAADWRAHYGSMWPRFSEWKQRYDPFGILTPGPGIF"
     misc_feature    5455..5470
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.97"
                     /tool="antismash"
     misc_feature    5531..5549
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            5754..6959
                     /locus_tag="IQ64_RS03965"
                     /old_locus_tag="IQ64_04130"
     CDS             5754..6959
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475238.1"
                     /locus_tag="IQ64_RS03965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04130"
                     /product="sensor histidine kinase"
                     /protein_id="WP_046912911.1"
                     /transl_table=11
                     /translation="MTQYIQNSALWALLVVTLVAATLIVRQRRAARTLRQEIAGLKNHY
                     GELESHYTESVRTAQQEAEGETRTALKSAMRTLQGLAAEQQRIISGLQRKYGDSVMLQD
                     LLEIDHMNAQFGRRAQSIAVLCEGWLGRHRDVASVYDVVRSAQGRIRHFQRAHILSKVD
                     FGVTSRAVEPVALALAELLDNATSYSSPDTVVEINVRSVPKGVCIIVDDAGVGMNEEEK
                     ARAEKLLTSERATGVSGLGNPPQFGFAVIGVLCERFGFTVSVDSTSPYGGVRAVVLLPD
                     DLLTDMPVPKQPAASVESVAPREEPSAVETRPSAYEPVPEPALPLGTTEDGLPKRRRKR
                     PMALVSTGPSAAPAAPKRRSEETAAIMAAFKQGTDAGRATHPEGERPGGTRDASSEGHE
                     VQ"
     misc_feature    5853..5855
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6956..7357
                     /locus_tag="IQ64_RS03970"
                     /old_locus_tag="IQ64_04135"
     CDS             6956..7357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475236.1"
                     /locus_tag="IQ64_RS03970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04135"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_005475236.1"
                     /transl_table=11
                     /translation="MNNDLSWMLDSALEIPGALHAVLVSSDGLLRARSKDVDKDDADKA
                     AAAMSGMQSLSRSLAFFCSRSDLRWQQTLVEFDGGWIFLISAGDGAYLAVSASSDVDMA
                     DITFRMQQLVGQLGKVMTAPPRESSVVRP"
     gene            7354..7731
                     /locus_tag="IQ64_RS03975"
                     /old_locus_tag="IQ64_04140"
     CDS             7354..7731
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475232.1"
                     /locus_tag="IQ64_RS03975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04140"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_005475232.1"
                     /transl_table=11
                     /translation="MTDSDRHEHEAAELVRPYVITGGRSLPGESQFSLITLVTAVVDQQ
                     QRPARLSPEEQNLLGMCVGGYLSVAEISGHLHLPVGVVKILLAALSEAGYLVTRPPATR
                     APVANLQILEEVLHGLQSKFG"
     misc_feature    7393..7395
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7706..8299
                     /locus_tag="IQ64_RS03980"
                     /old_locus_tag="IQ64_04145"
     CDS             7706..8299
                     /EC_number="3.6.5.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="IQ64_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04145"
                     /product="GTP-binding protein"
                     /protein_id="WP_013005331.1"
                     /transl_table=11
                     /translation="MVSSPSLDERAYVPGGETQTAVKILVVGHFAVGKTTFIGSISEIS
                     PLSTEETMTQAGEAIDDLKGVQGKTTTTVAMDFGRLTVSDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFAVIDLIEQYGLDYAIAVNHFDGTSIRDARALREALD
                     LLDDTPIVTCDARDERSSAEALITLVRYLMDRAR"
     gene            8313..9650
                     /locus_tag="IQ64_RS03985"
                     /old_locus_tag="IQ64_04150"
     CDS             8313..9650
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475230.1"
                     /locus_tag="IQ64_RS03985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04150"
                     /product="cytochrome P450"
                     /protein_id="WP_046912910.1"
                     /transl_table=11
                     /translation="MTSDSTFPAPPPGCPAHDSGMRVPLYGPEYAADPQAYYAYMRHYG
                     QTAPVEIAPGVDATLVTDHATALRLLQDSGNFRKDARRWRDVAEGKIGPDSPVVPMLGY
                     RPNAMFTDGAEHARLRQAITDSLAKVDSRRISDMTKRASDYLLAQVSARGSIDLMNDYV
                     KQLPLLVFNELFGCPADIGDRVVFGISGVFEGVNAEKANAVLGQAVFELVALKRARPAD
                     DVTSYLMRHEARLTDEELVHQLILLLGAGAEPLRNLIGNTLHRLLLHDRYADGGLIEEA
                     IDDTLWENPPMANYAPHYPAIDLEFGGTKMRAGDLVLVSMTAANTDPALATARQTGGRR
                     AHLSWSAGPHACPSKELARLVTMVAIENLLNRLHDIELAVPEDSLTWRPGPFHRALAAL
                     PCRFTPQVMQRPAPPRAETAARGDNAPAGRKTERGVWGSFLSWLKG"
     misc_feature    complement(9680..9693)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    9686..9699
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.67"
                     /tool="antismash"
     gene            10001..12586
                     /locus_tag="IQ64_RS03990"
                     /old_locus_tag="IQ64_04155"
     CDS             10001..12586
                     /EC_number="4.1.99.1"
                     /NRPS_PKS="Domain: Beta_elim_lyase (447-823). E-value:
                     9.7e-76. Score: 246.7. Matches aSDomain:
                     nrpspksdomains_IQ64_RS03990_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114547.1"
                     /locus_tag="IQ64_RS03990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04155"
                     /product="tryptophanase"
                     /protein_id="WP_050398136.1"
                     /sec_met_domain="indole_PTase (E-value: 5.3e-148, bitscore:
                     485.1, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAHGSGTGGTREDRTLGDLVTGQLRRLCQVSGLGPSDADTYAHV
                     LTDSLGAAAERSLDLPPPSRSFLSDDSTPVEFSLSFAPDAAPRLRVLLEPGCGADTLRE
                     DGRTGLRVVRSMARRWGFGTAQLDALEDLFLPPDPHGPLALWIALELCPGGVPRMKVYL
                     NPAASGATRAAGTIREALDRLGHRHAFDALPPADGYPFFALDLGDWAAPRVKIYATHHG
                     LPVAAVGGLCRMDSGPDSATLEEFLRTAGGFGDGAGQSSVAEARFDRRPVLTCHSFTRT
                     TGGPTGFTLHVPVRDYARDDAQALRWAGTVLGRHGLGTDTLARSLAAVTPRPPQDGAGL
                     IAYVALAHEQHQPPRVTTYISSEAYEVRPPNTPSADRTAPSPGRHESGPRHGNDQTFSS
                     TSGARISMEPYRIKVVEPIALTTRQQREAALERVHYNLFDLRAEEVTIDLLSDSGTGAI
                     SAAQLAAGMEGDESYAGSRSFYRFHETVTELTGYRHILPAHQGRAAERILFNTLLEPGG
                     IVLANTHFDTTRANVELSGCQAHDIPCAEARDLDSERPFKGNIDLDKLRTTLEGPDGSR
                     VRVVIMTITNNGGGGQPVSMENLKQTAEICRRHGVPMILDAARFAENAWLVTRHEEGYR
                     DRTPRQVAEEAFRLADGCVMSAKKDGIVHIGGFIGLNDPELAEKCERLLIATEGFATYG
                     GLAGRDLDMMATGLLEVTEPAYLAERADVASHLADRVRSAGVDILEPPGLHALYLNAGR
                     LLPHIPPHHYPGHALACRLYLEGGIRSAELGSLYLGEEDEDGNPTKSAPYELVRLALPR
                     RVYTRSHYDHVGRTLEQIVKNAESVHGYRIVEQSPILRHFRAKLQPVTG"
     aSDomain        11342..12469
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ64_RS03990_Beta_elim_lyase.1"
                     /evalue="9.70E-76"
                     /label="IQ64_RS03990_Beta_elim_lyase.1"
                     /locus_tag="IQ64_RS03990"
                     /protein_end="823"
                     /protein_start="447"
                     /score="246.7"
                     /tool="antismash"
                     /translation="DLLSDSGTGAISAAQLAAGMEGDESYAGSRSFYRFHETVTELTGY
                     RHILPAHQGRAAERILFNTLLEPGGIVLANTHFDTTRANVELSGCQAHDIPCAEARDLD
                     SERPFKGNIDLDKLRTTLEGPDGSRVRVVIMTITNNGGGGQPVSMENLKQTAEICRRHG
                     VPMILDAARFAENAWLVTRHEEGYRDRTPRQVAEEAFRLADGCVMSAKKDGIVHIGGFI
                     GLNDPELAEKCERLLIATEGFATYGGLAGRDLDMMATGLLEVTEPAYLAERADVASHLA
                     DRVRSAGVDILEPPGLHALYLNAGRLLPHIPPHHYPGHALACRLYLEGGIRSAELGSLY
                     LGEEDEDGNPTKSAPYELVRLALPRRVYTRSHYDHV"
     gene            12701..13117
                     /locus_tag="IQ64_RS03995"
                     /old_locus_tag="IQ64_04160"
     CDS             12701..13117
                     /EC_number="3.5.4.5"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475227.1"
                     /locus_tag="IQ64_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04160"
                     /product="cytidine deaminase family protein"
                     /protein_id="WP_046912909.1"
                     /transl_table=11
                     /translation="MTKTTDTHPVDHELIRAATDTARTRCRGDNHTMAAAARARDGRII
                     TAVNAYHFTGGPCAELVLIGAAAAQGAYELDTVVAVGDRDRGVVPPCGRCRQVLLDYFP
                     ALKVIVVVGDHTRTVPIADLLPAGYVWADHQLDA"
     gene            complement(13153..13998)
                     /locus_tag="IQ64_RS04000"
                     /old_locus_tag="IQ64_04165"
     CDS             complement(13153..13998)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475226.1"
                     /locus_tag="IQ64_RS04000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04165"
                     /product="class III extradiol dioxygenase subunit beta"
                     /protein_id="WP_199813382.1"
                     /transl_table=11
                     /translation="MIWGLATSHVPSIGAAMDRGKTEDPYWRPLFDGYAPARAWMARHT
                     PDVAVVVYNDHANAVDMSVTPTFAVGAAASYEVADEGWGSRPVPTVVGAPEFSDHLIES
                     LVDSSFDITVFQDLAVDHGLTVPLSVYCPDPGESWPCAVVPLLVNVIQYPQPTAARCLA
                     LGRALGEAIRSYPEDLKVAVFGTGGMSHQLAGARAGLINQDFDRMYLDAIEHDPEKLAA
                     LTREDYIREAGSEGIELIMWLIMRGALGPRIRRVHDAYHVPASNTAAGMVLFENRPLPR
                     "
     gene            complement(14000..14356)
                     /locus_tag="IQ64_RS04005"
                     /old_locus_tag="IQ64_04170"
     CDS             complement(14000..14356)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475218.1"
                     /locus_tag="IQ64_RS04005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04170"
                     /product="protocatechuate 4,5-dioxygenase subunit alpha"
                     /protein_id="WP_005475218.1"
                     /transl_table=11
                     /translation="MSSRTPHITGTYVFDTADNRRGRALNRLCGSLKEAGNRVRFSADE
                     GAYCEAYGLTAEQREAVLGRDWTRMLELGGSIFYVFKLAVLDQKSMQYLGGVFTGMTTE
                     EFAQALEAGGRSFG"
     gene            complement(14401..15153)
                     /locus_tag="IQ64_RS04010"
                     /old_locus_tag="IQ64_04175"
     CDS             complement(14401..15153)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-182). E-value: 7.4e-12. Score:
                     37.5. Matches aSDomain:
                     nrpspksdomains_IQ64_RS04010_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114549.1"
                     /locus_tag="IQ64_RS04010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04175"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_046912907.1"
                     /sec_met_domain="adh_short (E-value: 1.7e-33, bitscore:
                     108.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARSARVAVVTGAAGGLGGPLVRRLAADGFTVAALDITEPDDTA
                     GFDDRAGITGVRAWRCDVSDPAATRRTVEEIAEAFGGVDVLVNNAGLLSGRSGLLEATP
                     REMHRFFAVNAVGPLLMVQACVPWLVRSAHRGRVINVASRTFFTGSPGQLAYVASKGAL
                     IGVTRVMARELGEHGITVNAVAPAQVATPGTRAHSGDEVFAATMRQQAIQEYVTPEHFA
                     GLVSYLASPDGAMVTGQTLVCDGGGLLR"
     aSDomain        complement(14608..15132)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ64_RS04010_PKS_KR.1"
                     /evalue="7.40E-12"
                     /label="IQ64_RS04010_PKS_KR.1"
                     /locus_tag="IQ64_RS04010"
                     /protein_end="182"
                     /protein_start="7"
                     /score="37.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAAGGLGGPLVRRLAADGFTVAALDITEPDDTAGFDDRAG
                     ITGVRAWRCDVSDPAATRRTVEEIAEAFGGVDVLVNNAGLLSGRSGLLEATPREMHRFF
                     AVNAVGPLLMVQACVPWLVRSAHRGRVINVASRTFFTGSPGQLAYVASKGALIGVTRVM
                     ARELGEHGITVN"
     CDS_motif       complement(15070..15126)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IQ64_RS04010_0001"
                     /evalue="2.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IQ64_RS04010"
                     /protein_end="28"
                     /protein_start="9"
                     /score="10.4"
                     /tool="antismash"
                     /translation="VVTGAAGGLGGPLVRRLAA"
     gene            complement(15150..15431)
                     /locus_tag="IQ64_RS04015"
                     /old_locus_tag="IQ64_04180"
     CDS             complement(15150..15431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114550.1"
                     /locus_tag="IQ64_RS04015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04180"
                     /product="muconolactone Delta-isomerase family protein"
                     /protein_id="WP_020114550.1"
                     /transl_table=11
                     /translation="MEFLVRTENTLPPDTPDDVRASLREGERARARELREAGILKRLWR
                     VPGRNATIGLYEAADPAELHDALVSLPMWKWMDITVEALATHPQEKAP"
     gene            complement(15453..16166)
                     /locus_tag="IQ64_RS04020"
                     /old_locus_tag="IQ64_04185"
     CDS             complement(15453..16166)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (2-128). E-value: 2.3e-13.
                     Score: 42.3. Matches aSDomain:
                     nrpspksdomains_IQ64_RS04020_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114551.1"
                     /locus_tag="IQ64_RS04020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04185"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_046912906.1"
                     /sec_met_domain="PF00561 (E-value: 7.3e-11, bitscore: 34.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-13, bitscore:
                     42.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFVLLHGAWHGGWVWQRVAARLRAAGHDVHAPTLTGVSDRAHL
                     LGPQVGLATHVQDVVALIEAHDLRDVVLVGHSYAGQVVTGVADRVPERLAGRVHLDAFV
                     GDDGDAAIGLLPPTVAGHYRESVAGPGFGWLIPVRSLSVLGVREQSDLDWLGPRLTPHP
                     WLTYTEPLRLTGKADHVPGVFVECTDWMRVFTPHAERAAARGWPVHEIATGHEAMVTAP
                     GELADMLLDVAGSGL"
     aSDomain        complement(15783..16160)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IQ64_RS04020_Abhydrolase_1.1"
                     /evalue="2.30E-13"
                     /label="IQ64_RS04020_Abhydrolase_1.1"
                     /locus_tag="IQ64_RS04020"
                     /protein_end="128"
                     /protein_start="2"
                     /score="42.3"
                     /tool="antismash"
                     /translation="VFVLLHGAWHGGWVWQRVAARLRAAGHDVHAPTLTGVSDRAHLLG
                     PQVGLATHVQDVVALIEAHDLRDVVLVGHSYAGQVVTGVADRVPERLAGRVHLDAFVGD
                     DGDAAIGLLPPTVAGHYRESVA"
     gene            complement(16163..17191)
                     /locus_tag="IQ64_RS04025"
                     /old_locus_tag="IQ64_04190"
     CDS             complement(16163..17191)
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475211.1"
                     /locus_tag="IQ64_RS04025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04190"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_046912905.1"
                     /transl_table=11
                     /translation="MLSSHVRNGWYLGAWSDEIGRTLTRRWITDIPVCFYRLPDGGVTA
                     VEDRCPHRKYPLSLGHLDDEGTLQCDYHGYRFDGEGVCVGVAEQADRPKAALRRFPLVE
                     KDGVIWIWPGDPDLADARLLPDTSWLTDPHWTHVHGVVPLKARHLLLVENLLDLTHETF
                     LHPTSIGNAAVAATPIDVTVDGDRVGFSRRMVGIEAPPFYERSCGLTSPVDRWQDGEFH
                     PPGIFVLHIRVAATGTEEPEGFHMKVLYGMTPGRGNETHDFYALARDYLIDDEQLTEFQ
                     HKQQLAVMQEDVDALEAQELMYATDPGGTAESSIRSDLAALRGRRALAKMLAREQRGSV
                     SA"
     gene            complement(17255..18295)
                     /locus_tag="IQ64_RS04030"
                     /old_locus_tag="IQ64_04195"
     CDS             complement(17255..18295)
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475210.1"
                     /locus_tag="IQ64_RS04030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04195"
                     /product="PDR/VanB family oxidoreductase"
                     /protein_id="WP_046912904.1"
                     /transl_table=11
                     /translation="MTSPSTAAPDALPLGTAVATTTPAPRGTDYDGTVTVLSRQTVADG
                     VTSLLLAPRDGVPLPRWQPGAHIDVVLPTGTVRQYSLCGPTAVTDRWRIAVLREPDGRG
                     GSRWIHDEVRETSELRIRGPRNNFPLRQAARYLFVAGGIGITPLLPMIAEVHAAGADWS
                     LLYGGRSRASMAFLSELEGYGERVTVRPQDEYGLLDLAGHLGEPDPSAVVYCCGPAGLI
                     DAVEAHCATWPAGALNVERFAAAPGSHSDEGGGKGDEPFEVELRSSGVMLTVRPGQSVL
                     RAVEAAGVPVLSSCEEGICGSCETAVLAGDIDHRDALLTEDERAAGDTMLICVSRARGG
                     RLVLDL"
     gene            complement(18419..18721)
                     /locus_tag="IQ64_RS04035"
                     /old_locus_tag="IQ64_04200"
     CDS             complement(18419..18721)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475209.1"
                     /locus_tag="IQ64_RS04035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04200"
                     /product="hypothetical protein"
                     /protein_id="WP_046912903.1"
                     /transl_table=11
                     /translation="MTAAAAATHIWVPFRGTSLFVKFARGADAQDRAAGHRGLLTDAFP
                     SDGVTRDDRYGEPLWRVDAEHLHAVVEALWSTDQPLHIHLDQAPWHGREPGGRDE"
     gene            complement(18718..19467)
                     /locus_tag="IQ64_RS04040"
                     /old_locus_tag="IQ64_04205"
     CDS             complement(18718..19467)
                     /EC_number="3.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475208.1"
                     /locus_tag="IQ64_RS04040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04205"
                     /product="PIG-L deacetylase family protein"
                     /protein_id="WP_046912902.1"
                     /sec_met_domain="PIG-L (E-value: 1e-23, bitscore: 76.9,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTAPPPSDDALLVISAHAGDFVWRAGGAIALAAERGQRAKVLC
                     LSFGERGESAKAWRDGLGLDEIKRLRRTEAADAAATLGAEIEFLDAGDYPLRETPELVD
                     RIVHVYREVNPAVVLTHTLTDPYNGDHPAAARMALQARVLAQAIGYDAPGEPLGAPPVF
                     FFEPHQPEQCDFKPNVLLDITSVFARKRKAMECLAAQQHMWDYYTDLAKRRGVQLKRNA
                     GPNLGLSHGTMGEAYVRLYPETTGTLA"
     misc_feature    complement(19811..19829)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.87"
                     /tool="antismash"
     misc_feature    complement(19815..19828)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    19815..19829
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.58"
                     /tool="antismash"
     misc_feature    complement(19816..19829)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.93"
                     /tool="antismash"
     gene            19884..20567
                     /locus_tag="IQ64_RS04045"
                     /old_locus_tag="IQ64_04210"
     CDS             19884..20567
                     /GO_function="GO:0047443 -
                     4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475207.1"
                     /locus_tag="IQ64_RS04045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04210"
                     /product="4-carboxy-4-hydroxy-2-oxoadipate
                     aldolase/oxaloacetate decarboxylase"
                     /protein_id="WP_046912901.1"
                     /transl_table=11
                     /translation="MPSRHVVVRTIDRPAPDVVARLAEAGASTVHEAIGRRGFAGPDLK
                     PNQHDVRVAGPAVTVSSHPGDNLMIHAAVEVCRPGDVLVVTTTSPSTDGMFGELLATSL
                     AARGVIGLVTAAGVRDTVELREMGFHVWARAVSAQGTVKASPGSVNVPVTLGGVSVRPG
                     DVVVADDDGVVVVPRAEAEEAAELAEKRIAKEAVNREVLRSGTLGVDHYGLRARLAELG
                     VTYQD"
     gene            20725..21399
                     /locus_tag="IQ64_RS04050"
                     /old_locus_tag="IQ64_04215"
     CDS             20725..21399
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475206.1"
                     /locus_tag="IQ64_RS04050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IQ64_04215"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_046912900.1"
                     /transl_table=11
                     /translation="MSTSVTPPSTPAAIDVTGAIRDAVLRGEYVPRQRLVEADLCEQFG
                     VRRAGVRAAFQQLAAEGLVEIQRNRGARVREITFAEAVQITEARMVLEGLIAARAAERI
                     SPAGAETLRGIGAEMAKAVADGELAAYSDLNARLHRCVRDIAGHETADRLIEQLRAQVV
                     RHRFMLSRVPGRARASLPQHQRIIEAIVAGDPAEAEAAMRAHIASVVEALRALETSRTA
                     EG"
     misc_feature    22369..22382
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
ORIGIN
        1 ctgcctcgcc gtgaccgtcg gcgggacggt cgtgggcgtc ctcaacggcg tcatcgtcga
       61 gttcggccgc atcgactcct tcatcgccac cctcgggacc ggcagcatga tgtacgccgt
      121 gaccggctgg gtcaccgacg gcagccggat cgtccccggc ccccagggcc tcccacccgc
      181 cttcaccgac ctctacacct ccacgttgct cggcctcccg gtccccgcct tctacgtgct
      241 ggcgctcacc gtcgtcctct ggctggtgct ggaacggctc ccggtcggcc gctacctgta
      301 cgtcgtcggg tccaacccgc gcgccgccga cctcgtcggc atccctgtcc gcagatacac
      361 cgtctgcgcc ttcgccgcgt ccggcctgat cgtcggcctc gccggagtgc tgctcgcggc
      421 ccagcagcag atcggcaacc ccagcgtcgg cctcgactac ctgctgcccg ccttcgtcgg
      481 cgccctcctc ggctccaccg cgatcagacc cggccgcccc aacgccctgg gcaccctcgt
      541 cgccgtcacc gtcctcgccg tcggcctcac cggcatcgcc cagatgggcg ccgacttctg
      601 gacggtgccc ctgttccacg gcggcaccct gctcctcgcc gtcggcctcg ccggatacgc
      661 cgcccgccgc cgcatgcaca ccggcgtcct cgcggcccgc gacgcacccg tcgacccggc
      721 ggagccgccg ccgggcggta ccccatgacc caggtcgcgc gccccgccgc cgcgccccca
      781 ccgccccccg gccgcgccct cccgctggtc ccttcgcgag gagccctcgt gcaccacaga
      841 accaagaccg ccgccggcgc ccgcggagcc cggtgtgcgg ccaccgcgct gctgacggtg
      901 accaccgtcc tgctcgcagg ctgcgaacgc ggatcgtcga gcgatccgga gacctccgcc
      961 tcgggcccca acggctgccc gaaggtccat gccgaggccc gggccgccgt cggccgggcg
     1021 gagcggaccg atatcccctg gaacggcccg acctccggcc ccgaggccgt gaccggcaga
     1081 accatcgtgt acgtcgccca gaccatgacc aaccccggag tcgcgggcgc cgccgacggc
     1141 gtccggcagg ccgcgcgggc catcggctgg aacgtccggg tcgtcgacgg cggcggcacc
     1201 cccgccggta tccaggcggc gatgagcgag gcggtgacgc tgcgcccctc gggcatcgtc
     1261 gtcggcggct tcgaccccgg cgcgacctcg cagcagatcg cccgtgccga gcgggcgggc
     1321 atccccgtca tcggctggca cgcggtcgcc gcacccggcc ccagcaggcg tcccgccctc
     1381 ttcaccaaca tcaccaccca ggtcgaggac gtcgccagga tcagcgcgca gtgggtcgtc
     1441 tcgacctccg acggcgacgc cggggtcgtg atcctcaccg acgcctccat ccccttcgcc
     1501 aagaacaagt ccgacctgat cagagccgaa ctcgccacgt gcgcgggcgt gaagctcctg
     1561 tcgtacgtga acatcccgat ccccgacgcg agcagccgca ccccccgcga ggtggcctcg
     1621 ctcctgtccc gcttccagga ccggtggacc cactccgtcg ccatcaacga cctgtacttc
     1681 gccgatgccg cgcccgcctt ccgtgcggcc ggcaaggacg gctcgggtcc gcccttcaac
     1741 atcggcgccg gggacggcga cccctccgcc ttccagcgcg tcgacagcgg ccagtaccag
     1801 gcggccaccg tccccgaacc gctcaccctg cagggctggc agatcgtcga cgagttcaac
     1861 cgcgccttct cgggccgccc ggccagcggc tatgtggctc ccgtccacat cagcacggcc
     1921 gacaacagcg aaggcgccac gagctgggac ccgtcgggct accgggaggg gtaccggaag
     1981 atctggggca gatgaccgcg ccacctcgcc cgcgcgtgcg cccgacagcc cacgccgggt
     2041 gcgaccgcgg tgccggctgc ggccgccgcg gtggtcacag acgcaggacg atcagtgccg
     2101 tgtcgtcggt gttgccggag ggtgggagga gatccgccag cagggcgtcg gccagggtct
     2161 cggggtcgtg cttgcggtgg tgggtcaggg agtcggcgag gcgccgcagg cccgtgtcga
     2221 tggcctcggt gcggcgctcg atcagcccgt ccgtgtagag gaccagggtg gagttttcga
     2281 cgaaggacgt gcaggcctcg ggccgggcgg cgtgggtggg ccgggcggcg agcggcgggt
     2341 cggtggcgtg gtcgaggaag gtgacggtgc cgtcggggtg catgagggcg ggcggggggt
     2401 ggcccgcgca gctgtaggtg atggtgtggc tgtcccagtc gatgaaggtc gtcaccacgg
     2461 tggtcgactc ggcgccctcg acggagcggg cgtagaggtc gagggcctcc agcgcctgcg
     2521 ccggaccgtc ggagagacgg gtggccccgc tcagggcgct gcgcagctgc cccatggcgc
     2581 aggcggccgc cagaccgtgg ccgacgacgt cccccacggc caccgcgagg ccctccccgg
     2641 gcaggccgac caggtcgtac cagtcgccgc acacgttcag cgcgccgatg gccggccggt
     2701 accgtacggc cgcgtcgtgc tgtccggtcg ggccgggcgg gggcagcatc gcggcctgca
     2761 gggccagggc cacctcgcgt tcgtgggcgt gggccgtgcg cagccgttcg ttgacctcct
     2821 gcagttcccg ggcgcgggtg tacagctcgg cctccagcac ctgggcccgg ccgtcgcctc
     2881 cggggccgcc gcgggcgcgg atgagttcgg tgacctcctc cacccggtgg acgatcaggg
     2941 ccaccttccc gtcggggccg atcacgggcg cgttgaccgg gctccagtag tgctcctgcc
     3001 aggagccggg gcgctcggcg tcctcgatgt cgtagcggag cagcgccatc gtgtcgcgct
     3061 cgccggtgac caccgcgcgc agcatcgact cccgggtctc ccgcatgccg gccgcggccg
     3121 gttcgttcgg gttctcgggg aagacgtcga agatgtaccg gcccagcagc tgctcgcggg
     3181 agcgcccggc gagccgcagg aagtcgtcgt tggcgtcgac gtacacgaga tcgggcgtga
     3241 gcagcgccac catgccgggc agggcccgga agacctccgc atagtcgata tgcggttccc
     3301 tcatgtccag cctgccttgg cgccgagcgt cggtgtgccg ttccacgata ggcgtgaacg
     3361 ggccacggga cccggcagat ccgcagcatc gccgacgcgc ttcggccgcc cccgccacga
     3421 gggacgtccc acgtctctcc cgcaccacca cgtcccggcc gcctccgggc cgccgaccag
     3481 ccacgcgcat ccgatggggt gggaaggacc gaaagagtga agcccggaaa gagcgcttga
     3541 tccgccctct ccggtctgct ccactccttc gggctcttct tcgggccctt ccacgccgtt
     3601 ccgcaccgcg tcggacggtg ccggtcagtc cgcaccgcgt cggacggtgc cggtcagtcc
     3661 gcaccgcgtc ggacggtgcc ctgggtcaga agatgcccgg gccgggggtc aggatcccga
     3721 acgggtcgta gcgctgcttc cactcggaga accgcggcca catcgagccg tagtgcgccc
     3781 gccagtcggc cgcggtgaag gcacacgcgc cgtgcgggta gcgcaccccg cccacggccg
     3841 ccgcgtcctg gtagaagcgg tagttgcggt ccatcatccg tgccgcgaag tcggggtcgg
     3901 ggccggagcg cgcggcgtcg gtcagcacgc tgaccagcca gacccagggc ccgcccgcat
     3961 cgctgggcag ccgcagcagc ggtcggcggt agctcgaacg cagcatcggg aagaccagcc
     4021 cgaagccggt cgggcccagg tcctccgcgg tcagcgacga gaacaccgac gcgacgtact
     4081 cctcgacggc gtcgtccggc aggaacaggt ccgaccaggg cttgaccttc gcgtcccagt
     4141 ccaggttcgc cgcgaaggag tcgtacatgg tggtgaccag ggagatgtag tcgaggtagg
     4201 gggagtcctc gaaggccgcc gtggccgcgg cggggctgag accgcgcagc aggtgggacg
     4261 tgtcgggtgc gtccccgggg ttgtggaaga cggtggccca cagtgtcagg ggctgcgcgg
     4321 tgcccggctg ggggatgctg ccgagggaat cgaactcgcc ccggttcgcc aggacgcgga
     4381 cgtcccggaa gaacgtcggg atgtccgggt acccgatccg gtacgtgcgg gccagctgtt
     4441 tggcgggcac gaggtcgacg gtggcccgcg tgatcactcc gcactggccg agcccggcga
     4501 gcgccgcctc gaacagatcg gtgttctgcg tgtcggagca ccaccgcagc cggccgtcgc
     4561 ccgtgaccac ctgcagctga tcggcgtggt cgacctgggc accggcccgg taggccgaca
     4621 tcatcccgat gccgcccatg gacagggtcc cgccgaccgt cgtgccgagg tagctggtga
     4681 tcgacgccgg ggtgaggccc cgctcgtacg cggccgcgat caggtcctgc cacagcacac
     4741 cggcgtcgac gtcggcgccg tccgtgccga tcgagtggat ggtgtccagc gaccgcatct
     4801 cgatgaccag gccgccgctc acgagcggct ggccgaacat cgcgtggtgc gcgccggccg
     4861 gggcgacctc gatgccgtgg tcggcgcaga agccgaccat cttccggatg tcctgcacgg
     4921 aacccggccg gagtaccgcg cacggtctga ggaacacgat gttgccctgg tcgtgcgcat
     4981 tggccgcgag ggacgcggcg tcgaagacga gggtgccgtc gagcgggggc acggtggcga
     5041 acgcggagtt ctccgctgcc gccgcctcgg gcacccactg ccgggcgatc aggtcgaagc
     5101 cggccacgag ggccaccgtc ccggctccga accgggccag gaactgacgc ctgttgaggg
     5161 cactgtgttc tttgtgcgac atgacagcct ccgtgatgtc gacgcggcgg atcgtcggca
     5221 cgccgccgcg ggttcgtcgt ccttttctcg gagcggaatc agccgggcga gccgtgccgg
     5281 ccgacggccg ggcaccgcgg tgcgtggcgc gaaccgagcc cggagccggg ccggcgctcc
     5341 ccacgcacag cgatctcccc ctgacgttcc gcttaccgcc catcatgact tccggggggc
     5401 tttccgcgcg acggtccgga tcatcaaccg cggtccgaga caaggccggt ggacgactac
     5461 acgagtcaac gccgctcgcg ggtacggcag tcgactgcgg caatgcggct tgtgcccgtg
     5521 ttcaacacat tccggttggg ctcaactgcc gggacaagtg ccctggttga cgcctcgtca
     5581 tcagcttgag tgatgatacg atcacggcac ttaccgagtg gacggatggg tgcaaaagga
     5641 gcatccgtcg tccttggtga attcctcgtg gcaaccctgg aatggctgac cttcggtatg
     5701 tgtgaattga caggaattca gtagctggct atcggccgcc tgaagagggt ctcatgacgc
     5761 aatacataca aaattcggcg ctgtgggcac tccttgtcgt aacccttgtc gccgccaccc
     5821 tcatcgttcg tcagcgacgg gcggcgcgga cattacggca ggagatcgca gggctcaaga
     5881 accactacgg tgagctggag agccactaca cggagtccgt ccgcacggcc cagcaggaag
     5941 ccgaaggcga gacgaggacc gcgctgaagt ccgccatgcg gaccctgcag ggcctcgccg
     6001 ccgaacagca gcgcatcatc tccggactgc agcgcaagta cggcgactcc gtcatgctcc
     6061 aggacctcct ggagatcgac cacatgaacg cgcagttcgg ccggcgggcc cagtccatcg
     6121 ccgtcctgtg cgagggctgg ctcggccggc accgcgacgt cgcctcggtc tacgacgtgg
     6181 tccgcagcgc ccagggcagg atccgccact tccagcgggc gcacatcctg tccaaggtcg
     6241 acttcggcgt caccagccgg gccgtcgaac cggtggcact ggccctcgcg gaactgctcg
     6301 acaacgcgac cagctactcc agcccggaca ccgtggtcga gatcaacgtc cgctccgtgc
     6361 ccaagggcgt ctgcatcatc gtcgacgacg ccggtgtcgg catgaacgag gaggagaagg
     6421 ccagggccga gaagctcctg acgagcgagc gggccacggg cgtctccgga ctgggcaacc
     6481 ctccgcagtt cggcttcgcg gtgatcggcg tgctctgcga gcggttcggc ttcaccgtgt
     6541 cggtggactc cacctccccc tacggaggcg tgcgagcggt cgtgctgctg cccgacgacc
     6601 tgctcaccga catgccggtg cccaagcagc cggccgcgtc ggtggagtcg gtcgcgccga
     6661 gggaggagcc gtcggccgtc gagacgcgcc cctcggcgta cgagccggtc cccgaacccg
     6721 cgctgcccct cggcacgacc gaggacggcc tgcccaagcg gcggcgcaag cggccgatgg
     6781 ccctggtctc gaccggtccg tccgccgccc cggccgcccc caagcgccgc agtgaggaga
     6841 cggcagccat catggccgcc ttcaagcagg gcacggacgc cggccgcgcc acacatccgg
     6901 agggggagcg gccgggcgga acccgtgacg cgagcagtga agggcacgag gtccaatgaa
     6961 caacgatctt tcctggatgc ttgacagcgc cttggagatc cccggagccc tccacgcggt
     7021 tctggtctcc tccgacgggc tgctgagggc acgctcgaag gacgtggaca aggacgacgc
     7081 cgacaaggcc gccgccgcga tgagcggcat gcagtcgctc agccggtccc tggcgttctt
     7141 ctgctcccgc tcggacctgc gctggcagca gaccctcgtc gagttcgacg gcggctggat
     7201 cttcctcatc tccgccggcg acggcgccta cctcgccgtg tcggcctcct ccgacgtcga
     7261 catggccgac atcaccttcc gtatgcagca actcgtcgga caactgggca aggtcatgac
     7321 cgccccgccc cgggagagca gcgtggtacg gccatgaccg attccgacag gcacgagcac
     7381 gaagccgccg aattagtacg cccgtacgtc atcaccggtg gccgcagcct tcccggggag
     7441 agtcagttct ccctcatcac gctggtcacg gcggtcgtcg accagcagca gcggcctgcc
     7501 cgcctctcac ccgaggagca gaacctgctg gggatgtgcg tcggcggtta cctctccgtc
     7561 gccgagatct ccggacacct gcacctgccg gtgggggtcg tgaagatcct gctggcggcc
     7621 ctctccgagg ccggctacct cgtcacccgc ccgccggcga cccgtgcgcc cgtcgccaac
     7681 ctgcagatcc tcgaggaggt gctccatggt ctccagtcca agtttggatg agcgggccta
     7741 cgttcccggc ggagagacgc agaccgccgt gaagatcctg gtcgtcgggc acttcgcggt
     7801 gggcaagacc acgttcatcg ggtcgatctc cgagatctcg ccgctctcca ccgaggagac
     7861 gatgacccag gctggcgagg cgatcgacga tctcaagggc gtccagggca agaccaccac
     7921 cacggtcgcc atggacttcg gtcgcctcac cgtcagcgac cgtgtcgtgc tgtacctctt
     7981 cggcacaccc ggccagcagc gcttcgtaca gatgtgggag gacatggcac gcggcgccct
     8041 cggggcgctc gtgctcgtcg accccgagcg gctggccgac tcgttcgccg tgatcgacct
     8101 gatcgagcag tacggactcg actacgcgat cgcggtcaac catttcgacg gcacgtccat
     8161 acgtgacgcc agggcactgc gcgaagcgct cgatctgctc gacgacaccc ccatcgtcac
     8221 ctgcgacgcg cgggacgagc ggtcgtcggc cgaagcactg atcacgctgg tccgctactt
     8281 gatggaccgc gcccgttagg agcagagcag acatgacctc cgattccacc ttccccgcac
     8341 ccccgcccgg ctgcccggcc cacgacagcg ggatgcgggt cccgctgtac ggaccggagt
     8401 acgccgccga cccgcaggcg tactacgcct acatgcggca ctacgggcag accgcaccgg
     8461 tcgagatcgc gcccggcgtc gacgccaccc tcgtcaccga ccacgcgacc gcgctgaggc
     8521 tcctccagga ctccggcaac ttccgcaagg acgcgcgccg ttggcgggac gtcgccgaag
     8581 gcaagatcgg cccggacagc cccgtcgtcc ccatgctggg gtaccgcccc aacgccatgt
     8641 tcaccgacgg tgccgaacac gcccggctcc gccaggccat caccgacagc ctggccaagg
     8701 tcgactcccg ccgcatcagc gacatgacca agcgggcctc cgactacctc ctggcccagg
     8761 tctccgcccg cggctccatc gacctgatga acgactacgt caagcagctg ccgctgctcg
     8821 tgttcaacga gctgttcggc tgcccggcgg acatcggcga ccgggtcgtc ttcggcatct
     8881 ccggagtctt cgagggcgtc aacgccgaga aggccaacgc ggtactggga caggccgtgt
     8941 tcgaactggt cgcgctcaag cgcgccaggc ccgccgacga cgtcacctcc tacctgatgc
     9001 ggcacgaggc acggctgacc gacgaggaac tcgtccacca gctgatcctg ctcctcggcg
     9061 cgggtgccga accgctgcgc aacctcatcg gcaacaccct gcaccggctg ctcctgcacg
     9121 accggtacgc cgacggcggc ctcatcgagg aggccatcga cgacacgctg tgggagaacc
     9181 cgcccatggc gaactacgcg ccccactacc ccgccatcga cctggagttc ggcggcacga
     9241 agatgcgggc cggcgatctc gtcctcgtca gcatgacggc ggccaacacc gacccggcgc
     9301 tcgcgacggc ccgtcagacc ggcggccggc gcgcgcacct gtcctggagc gcgggcccgc
     9361 acgcctgccc ctccaaggaa ctcgcccgcc tcgtcaccat ggtggccatc gagaacctgc
     9421 tcaaccgtct gcacgacatc gaactcgcgg tgcccgagga cagcctcacc tggcgacccg
     9481 gccccttcca ccgcgcgctc gccgcgcttc cctgccgctt caccccgcag gtgatgcagc
     9541 gtccggcccc gccccgggcg gagacggccg cacgcggcga caacgccccc gcgggccgga
     9601 agaccgagcg aggggtgtgg ggctccttcc tgtcctggtt gaaggggtga cacccgcaac
     9661 cgcctgtgac ggaaggcact gcatgagctt tcaaccaaag gggtagtaac gcggcggcaa
     9721 ttcgtggtga ccaacgaaca aagggaggtg tcgtggacca catatccacc ggcgccgctt
     9781 ctgctcgaca tccggacatg taccgccgct cccgacggca caccgcatta acccccgtgg
     9841 aggccacgaa gggcgagatc cgccaccggt caccacgaga cgagataccc gccgaggtcg
     9901 gcgggtatct ttgcgtctcc tcctatacac cggccgccga ccaggggaaa cccgcgtccc
     9961 cggcaccgtc cccccactcc gagcagcggt gggagcaccg gtgagcgccc acgggtccgg
    10021 caccgggggg acccgcgagg accggacgct cggcgacctc gtgacgggcc aactgcggcg
    10081 gctgtgccag gtgtccgggc tcggcccgtc cgacgcggac acctacgcgc acgtactgac
    10141 cgactccctc ggagcggcgg ccgagcggtc cctggacctg ccgcccccct cccggagctt
    10201 cctgtccgac gactccaccc ccgtggagtt ctcgctctcc ttcgcaccgg acgcggcccc
    10261 caggctgcgg gtgctgctgg agccgggatg cggcgccgac acccttcgcg aggacgggcg
    10321 caccggactg cgcgtcgtcc ggtccatggc acgacgctgg ggcttcggca ccgcacaact
    10381 cgacgctctg gaggacctgt tcctgccccc cgacccgcac ggcccgctgg ctctgtggat
    10441 cgctctggag ctgtgccccg gcggcgtccc caggatgaag gtgtacctga acccggcggc
    10501 gtccggcgcg acgagagccg ccgggacgat ccgggaagcg ctggaccggc tcggccaccg
    10561 gcacgccttc gacgcgctgc ccccggccga cggctacccg ttcttcgccc tcgacctggg
    10621 ggactgggcg gcgccccggg tgaagatcta cgccacccac cacgggctgc cggtggcagc
    10681 cgtcggcggc ctgtgccgga tggactccgg ccccgacagc gcgacgctgg aggagttcct
    10741 ccgcacggcg ggcggcttcg gcgacggagc agggcagtcc tcggtcgcgg aggcccggtt
    10801 cgaccggcgc cccgtcctga cctgccactc cttcacccgg accaccggcg gtcccaccgg
    10861 cttcacgctc cacgtcccgg tcagggacta cgcccgggac gacgcgcagg cactgcgctg
    10921 ggccggaacc gtcctcggcc gccacgggct cggcaccgac accctcgccc ggtcactggc
    10981 cgccgtcacc ccccggccgc cgcaggacgg cgccggactc atcgcctacg tggcgctggc
    11041 ccacgagcag caccagcctc cccgggtgac cacgtacatc tcgtcggagg cctacgaggt
    11101 ccggcccccg aacaccccct cggcggaccg caccgcaccg tcccccgggc ggcacgagtc
    11161 cggcccccgg cacggcaacg accagacatt cagcagtacg tcaggagcaa ggatcagcat
    11221 ggagccctac cgcatcaagg tcgtcgagcc catcgcgctc accacccggc aacagcgcga
    11281 ggcggcgctg gagcgggtgc actacaacct cttcgacctg cgcgccgagg aggtgaccat
    11341 cgacctgctc agcgactcgg gcaccggcgc catctccgcg gcccagctcg ccgcggggat
    11401 ggagggcgac gagtcctacg cgggctcacg ctccttctac cgcttccacg agaccgtgac
    11461 cgagctgacc ggctaccggc acatcctccc ggcccaccag ggacgcgccg ccgaacgcat
    11521 cctgttcaac acccttctcg aacccggcgg catcgtcctg gccaacaccc acttcgacac
    11581 cacccgggcg aacgtggaac tctccgggtg tcaggcccat gacatcccgt gcgccgaggc
    11641 ccgcgacctc gacagcgaac gccccttcaa gggcaacatc gacctcgaca agctccgcac
    11701 cacactcgaa ggaccggacg gctcccgcgt ccgcgtggtg atcatgacga tcaccaacaa
    11761 cggaggcggc ggccagcccg tctccatgga gaacctcaag cagaccgccg agatctgccg
    11821 ccgccacggc gtccccatga tcctggacgc cgcccggttc gccgagaacg cctggctcgt
    11881 cacgcgccac gaagagggct accgcgaccg cacaccccgc caggtcgccg aggaagcgtt
    11941 ccgtctcgcc gacggctgcg tcatgagcgc caagaaggac ggcatcgtcc acatcggcgg
    12001 cttcatcggc ctcaacgacc ccgaactcgc cgagaagtgc gaacgcctcc tcatcgccac
    12061 cgagggcttc gccacctacg gcggcctcgc cggccgcgac ctcgacatga tggccaccgg
    12121 cctgctggag gtgaccgaac ccgcctacct cgccgaacgc gccgacgtcg cctcccacct
    12181 cgccgaccgc gtccgctcgg ccggcgtcga catcctcgaa cccccgggcc tgcacgccct
    12241 ctacctcaac gccggacgcc tgctcccgca cataccgccc caccactacc cgggccacgc
    12301 cctcgcctgc cgcctctacc tcgaaggcgg catccgctcg gccgaactcg gctccctcta
    12361 cctcggcgag gaggacgagg acggcaaccc caccaagagc gcgccgtacg aactggtccg
    12421 actggcgctc ccacgccgcg tctacacccg cagccactac gaccacgtcg gccggaccct
    12481 ggaacagatc gtcaagaacg cggaatccgt ccacggctac cgcatcgtgg agcagtcccc
    12541 gatcctgcgg cacttccgcg ccaaactgca gccggtgacc ggctgacaac cccggccagg
    12601 tgacatcgac gccccgacgg agctgcccca ccctccgccg gggcgtcgcg cgcgccgatc
    12661 acacgaagac gaacaccaag acgcacacca agccgagacg atgacgaaga cgaccgatac
    12721 tcaccccgtc gaccacgaac tcatccgggc cgcgaccgac accgcgcgca cccgctgccg
    12781 gggcgacaac cacaccatgg cagccgcggc ccgcgcccgg gacggccgca tcatcaccgc
    12841 cgtgaacgcc taccacttca ccggaggccc ctgcgccgaa ctggtgctca tcggcgcggc
    12901 ggccgcccag ggagcctacg aactcgacac cgtcgtcgcc gtgggcgacc gcgaccgggg
    12961 agtcgtaccg ccctgcggcc gatgccgcca ggtcctcctc gactacttcc ccgccctgaa
    13021 ggtcatcgtc gtcgtgggcg accacacccg gaccgtgccc attgccgacc tgctgccggc
    13081 cggctacgtc tgggccgacc accagctcga cgcctagcgg ccgcagcacg cggtggaacc
    13141 cacccggacc ggctatcgcg gcagtggacg attctcgaac agcaccatcc cggccgccgt
    13201 gttggaggcg ggcacgtgat aggcgtcgtg cacacggcgg atgcgtggcc cgagggcgcc
    13261 gcgcatgatc agccacatga tgagctcgat tccctcggag ccggcctcgc ggatgtagtc
    13321 ctcccgggtc agcgccgcca gcttctccgg gtcgtgctcg atggcgtcca ggtacatccg
    13381 gtcgaagtcc tggttgatca gtcccgcgcg ggcgcccgcg agttggtggg acatgccgcc
    13441 ggtaccgaag acggcgacct tgaggtcctc ggggtaggag cggatcgcct cgccgagggc
    13501 cctgcccagg gccaggcacc gtgccgccgt gggctgcggg tactggatga cgttgaccag
    13561 gagggggacg acggcacacg gccagctctc cccggggtcg gggcagtaca ccgacaacgg
    13621 cacggtcaga ccgtggtcca cggcgagatc ctggaacacc gtgatgtcga aggaggagtc
    13681 gaccaggctt tcgatgagat ggtcggagaa ctccggggcg ccgacgacgg tcgggaccgg
    13741 acggctgccc catccttcgt ccgccacctc gtacgaggcc gccgcgccga ccgcgaaggt
    13801 cggtgtgacg gacatgtcga cggcgttggc gtggtcgttg tagacgacca cggccacgtc
    13861 cggcgtgtgc cgggccatcc acgcacgggc cggcgcgtac ccgtcgaaca gtggtctcca
    13921 gtacgggtcc tcggtcttcc cgcggtccat cgccgcaccg atcgacggca cgtgcgaggt
    13981 ggccagaccc caaatcacct cagccaaagc tccgccctcc cgcttccagt gcctgagcga
    14041 actcctcggt ggtcatgccg gtgaacaccc ctccgaggta ctgcatggac ttctggtcga
    14101 gtaccgcgag cttgaacacg tagaagatgg agccgcccag ctccagcatc cgtgtccagt
    14161 cccggcccag gaccgcctcc cgttgctcgg ccgtgagtcc gtacgcctcg cagtacgcgc
    14221 cctcgtccgc gctgaaccgc acgcggttgc cggcctcctt caacgagccg cagagccggt
    14281 tcagcgcccg gccccgacgg ttgtcggcgg tgtcgaagac gtaggtaccc gtgatgtggg
    14341 gtgtgcggct ggacatggcc ttcctctccc tcctcttccg ctgtcgtgtc cggcaaccgc
    14401 tcagcgcagc agcccaccgc cgtcgcagac gagcgtctga ccggtgacca tggccccgtc
    14461 cggcgaggcc agatacgaga cgagtcccgc gaagtgctcc ggggtgacgt actcctggat
    14521 cgcctgctgc cgcatggtcg cggcgaacac ctcgtcgccg gagtgggccc tggtgcccgg
    14581 ggtggcgacc tgggcggggg ccaccgcgtt gacggtgatc ccgtgctcgc ccagttctcg
    14641 cgccatcacc cgggtcacgc cgatcagcgc acccttgctg gcgacgtagg cgagttggcc
    14701 cggtgagccg gtgaagaagg tgcgggaggc gacgttgatc acccgtccgc ggtgcgcgct
    14761 cctgaccagc cacggcacgc acgcctgcac catgagcagc gggccgacgg cgttgacggc
    14821 gaagaagcgg tgcatttccc gcggggtggc ctccagcaga ccgctccggc cggacagcag
    14881 gcccgcgttg ttgaccagga cgtccacgcc gccgaaggcc tccgcgatct cctcgacggt
    14941 acggcgggtg gcggccgggt cgctgacgtc acaacgccac gcccgtacgc cggtgatccc
    15001 tgccctgtcg tcgaaccccg ccgtgtcgtc cggttcggtg atgtccaggg cggcgacggt
    15061 gaacccgtcg gcggccagcc ggcgcacgag gggcccgccg agtccgcccg ccgcgcccgt
    15121 gaccaccgcg acccgagcgc tccgcgcggt cacggtgcct tctcctgcgg atgggtggcc
    15181 agggcctcca cggtgatgtc catccacttc cacatcggca gggacaccag ggcgtcgtgc
    15241 agctccgccg ggtcggcggc ctcgtacagg ccgatggtcg cgttgcggcc cggtacccgc
    15301 cacagccgtt tcaggatccc ggcctcgcgg agttcccgcg cccgtgcgcg ctctccctcg
    15361 cgcaggctcg ctcggacgtc gtcaggggtg tccgggggca gggtgttctc ggtgcggacg
    15421 aggaattcca tgcgggtctc cacctttcag ggctacaggc cggagccggc gacatccagc
    15481 aacatgtccg ccagttcgcc gggggcggtg accatggcct cgtgaccggt ggcgatctcg
    15541 tggaccggcc aaccccgggc ggcggcgcgc tcggcgtgcg gggtgaacac ccgcatccag
    15601 tcggtgcatt cgacgaagac gccgggcacg tggtcggcct ttccggtcag ccgcaacggc
    15661 tcggtgtagg tcagccacgg gtgcggggtg aggcgggggc cgagccagtc caggtccgac
    15721 tgttcccgca cccccagaac gctcagcgag cgcaccggga tgagccagcc gaagcccggc
    15781 ccggccacgg actcccggta gtggccggcg acggtggggg gcagcaggcc gatcgccgcg
    15841 tccccgtcgt cgccgacgaa ggcgtcgagg tggacccgtc cggccaaccg ctccgggaca
    15901 cggtcggcga cgccggtgac gacctgaccg gcgtagctgt gtccgacgag caccacgtcc
    15961 cgcaggtcgt gggcctcgat cagggccacg acgtcctgga cgtgcgtagc gaggcccact
    16021 tgaggaccga gcaggtgggc gcggtcgctc actccggtga gagtgggggc gtgcacgtcg
    16081 tgcccggcgg cgcgcaaccg cgctgccaca cgctgccaca cccaaccgcc gtgccaggcg
    16141 ccgtgcagga ggacgaagac gctcatgccg acacgcttcc ccgctgctcg cgggccagca
    16201 tcttcgccag cgcccggcgt ccgcgcaggg cggccagatc ggagcggatg ctggactcgg
    16261 cggtgccgcc gggatcggtg gcgtacatca actcctgggc ctccagggcg tcgacgtcct
    16321 cctgcatcac cgccagctgc tgcttgtgct ggaactcggt gagctgctcg tcgtcgatga
    16381 ggtagtcgcg ggccagggcg tagaagtcgt gggtctcgtt gccccgcccg ggcgtcatgc
    16441 catacagcac cttcatgtgg aagccctccg gttcctcggt gccggtggcc gcgacgcgga
    16501 tgtggaggac gaagatgccg ggcgggtgga actcgccgtc ctgccagcgg tccaccggtg
    16561 aggtcagccc gcacgacctc tcgtagaagg gcggggcctc gatgccgacc atgcggcggc
    16621 tgaagccgac ccggtcaccg tccacggtga cgtcgatcgg ggtggcggcc acggccgcgt
    16681 tgccgatgct cgtcgggtgc aggaaggtct cgtgcgtgag gtcgagcagg ttctccacca
    16741 gcaacaggtg gcgcgccttc agcggtacga cgccgtggac gtgggtccag tgcgggtcgg
    16801 tcagccacga ggtgtccggc agcaggcgcg cgtcggccag gtcggggtcg ccgggccaga
    16861 tccagatgac gccgtccttc tccaccaggg ggaagcggcg cagggcggcc ttgggccggt
    16921 cggcctgctc ggcgacgccg acacacacgc cctcaccgtc gaagcggtaa ccgtggtagt
    16981 cgcactggag ggtgccctcg tcgtccaagt ggcccaggga cagcgggtac ttgcggtgcg
    17041 gacagcggtc ctcgacggcg gtcacgccgc cgtcgggcaa ccggtagaag cagaccggga
    17101 tgtccgtgat ccagcggcgg gtgagcgtcc ggccgatctc gtcggaccag gctcccaggt
    17161 accagccgtt gcgcacgtgt gaggagagca tggacggcaa cgcctttctc ttcgaagtct
    17221 tcttcgggcg gcgggtcgag acccaggagc caggtcagag gtccaggacg agacggcctc
    17281 cgcgggcgcg ggagacgcag atcagcatgg tgtcgccggc cgcccgctcg tcctcggtca
    17341 gcagggcgtc ccggtggtcg atgtcgcccg ccagcacagc ggtctcgcag gagccgcaga
    17401 tgccctcctc gcaggaggac aggaccggca cgcccgccgc ttccacggcc ctgagcaccg
    17461 actgtcccgg ccgcacggtg agcatcactc cggacgagcg cagctccacc tcgaacggct
    17521 cgtcaccctt gccgccaccc tcatccgagt gcgacccggg ggccgcggcg aaccgctcca
    17581 cgttgagcgc tcccgccggc caggtggcgc agtgggcctc gacagcgtcg atcagcccgg
    17641 ccgggccgca gcagtacacc actgcggagg ggtcgggttc gccgagatgg ccggcgaggt
    17701 cgagcaggcc gtactcgtcc tgcggccgta cggtcacacg ctcgccgtag ccctccagct
    17761 cggacaggaa cgccatggac gcccggctcc ggcccccgta gagcagggac cagtccgctc
    17821 cggccgcgtg gacctcggcg atcatcggca gcagcggggt gatgccgatg ccgccggcga
    17881 cgaacaggta ccgcgccgcc tgccgcaggg ggaagttgtt ccgcggaccc cgtatccgca
    17941 gctcgctcgt ctcgcggacc tcgtcgtgga tccaccgcga tccgccccgt ccgtcgggct
    18001 cccgcagcac cgcgatgcgc cagcggtcgg tgacggccgt cggaccgcac agcgagtact
    18061 ggcggacggt gcccgtgggg aggaccacgt cgatgtgcgc gcccggctgc cagcgcggca
    18121 gcggtacgcc gtcgcgcggt gcgagcagca gggacgtgac accgtccgcc accgtctggc
    18181 gggacagcac ggtgaccgtg ccgtcgtagt cggtgccgcg tggcgccggg gtcgtcgtgg
    18241 caacggccgt cccgagcggg agcgcgtccg gggcggcggt cgacgggctc gtcatgcgtg
    18301 tcatctcctc ggcgcggtcg gtgctgcggt ggcaccttcg acgctagtcg cgggggaacg
    18361 cgcaggtcgt cgcgctaatg accggacccg gacggcggaa ggtccgggcc ccactacgtc
    18421 attcgtcgcg cccgccgggc tcccggccgt gccacggggc ctggtcgagg tggatgtgca
    18481 gcggctggtc cgtgctccac agcgcttcca ccacggcgtg cagatgctcc gcgtcgaccc
    18541 gccacagagg ctcgccgtac cggtcgtccc gtgtgacgcc gtccgacggg aaggcgtcgg
    18601 tcagcagccc ccggtgaccg gcggcacggt cctgggcgtc cgctccccgc gcgaacttca
    18661 cgaacaggga ggtgccgcgg aagggcaccc agatgtgcgt ggccgcggcg gccgcggtca
    18721 tgccagcgtc cccgtggtct cggggtagag ccgtacgtag gcctcgccca tggtgccgtg
    18781 cgaaaggccc agattgggac cggcgttgcg cttgagctgg accccgcgcc gcttggcgag
    18841 atcggtgtag tagtcccaca tgtgctgctg ggcggccagg cactccatgg ccttgcgctt
    18901 cctggcgaag acgctcgtga tgtcgagcag gacgttcggc ttgaagtcgc actgctcggg
    18961 ctggtgcggt tcgaagaaga acaccggggg agcacccagg ggctctccgg gcgcgtcgta
    19021 gccgatcgcc tgagcgagca cacgcgcctg gagtgccatg cgggcggcgg cgggatggtc
    19081 gccgttgtag gggtcggtga gggtgtgcgt gaggacgacc gcggggttca cctcccggta
    19141 gacgtgcacg atgcggtcca ccaactcggg tgtctcccgc agggggtagt cccctgcgtc
    19201 caggaactcg atctcggcgc ccagcgtggc ggcggcgtcg gcggcctccg ttcggcgcag
    19261 tcgcttgatc tcgtcgaggc cgagaccgtc ccgccaggct ttggcggact caccgcgttc
    19321 gccgaagctc aggcacagca ccttggcgcg ctgaccgcgt tcggcggcca gggcgatggc
    19381 gccgccggca cgccagacga agtcgccggc gtgcgcgctg atcaccagca gggcgtcgtc
    19441 ggagggtggg ggtgcggtga gggccatggg ggctccttga gtcggacggg accgggcgga
    19501 tcgccatgtc cgcgggacgg tcggcgggtg ccgagatgtc ggcggtcttg agtgccggtg
    19561 acgggccgcc gagtcgcgtg cccgcagacc tggcgcaagc aggtcctgca cggggttcgg
    19621 cacgaggtgc ggcatgaggc ccggcacgtg gttcggcatg agattcggca agtggtgcgg
    19681 cgagtggtac ggccgtgaag cgacgccgtg tccgaggacg agcatccggc gaagtcggcc
    19741 gcagtggctc gacgttgaca cgaggcgagc gggtcgggac gagccgacga cgcgttgtca
    19801 ccatatcgcg aatgtttttg ttgacaatag tgttgacttc aagcaatctc ctgacaccaa
    19861 tcccggatca gaccggagga gacatgccca gccgtcatgt cgtcgtcagg accatcgacc
    19921 gaccggcccc ggacgtcgtc gcccggctcg ccgaggccgg ggcgtccacc gtccacgagg
    19981 ccatcggccg ccgtggcttc gcgggccccg acctgaaacc gaaccagcac gatgtgcggg
    20041 tggcgggccc ggcggtgacc gtcagctcgc atcccgggga caacctgatg atccacgcgg
    20101 ccgtcgaggt gtgccgcccc ggagacgtcc tcgtggtgac caccacctcc ccgtccacgg
    20161 acggcatgtt cggcgaactg ctggcgacgt ccctcgccgc ccgcggcgtc atcggcctgg
    20221 tcacggcggc cggggtgcgc gacaccgtgg aactgcggga gatgggcttc cacgtctggg
    20281 cccgtgccgt gtccgcgcag ggcacggtga aggcgtcccc gggctcggtc aacgtgcccg
    20341 tgacgctcgg cggggtgtcc gtccggcccg gggacgtcgt cgtcgccgac gacgacggtg
    20401 tggtcgtcgt acctcgcgcg gaggcggagg aggcggccga gctggcggag aagcggatcg
    20461 cgaaggaagc cgtcaaccgg gaggtcctgc gttcggggac gctgggcgtc gaccactacg
    20521 gactgcgcgc ccggctcgcc gaactcggcg tcacctacca ggactgaccc ctcgccccgc
    20581 tccggaggtg ccgcgggaga gcggcacctc cggcagtgaa cgccgaccgc gatgcccgcc
    20641 ttgggccggc gcagcccgca cgaccgcgcg gaacgcaccg gccctcctcg ctcaagaacc
    20701 cacggtggat ggtgaccagg cacgatgagc acttccgtta ctccccccag tactcccgcc
    20761 gcaatcgacg tcaccggtgc gatccgggac gcggtgctgc gcggcgagta cgtaccgcgt
    20821 cagcgcctgg tcgaggcgga tctctgcgaa cagttcggcg tccgccgcgc cggcgtgcgg
    20881 gcggcgttcc agcaactggc ggcggagggg ctggtggaga tccagcgcaa ccgcggcgcc
    20941 cgcgtccggg agatcacctt cgccgaggcc gtccagatca ccgaggcccg catggtgctg
    21001 gaagggctga tcgccgcccg cgcggcggag cggatcagcc cggcgggggc cgagaccttg
    21061 cgcgggatcg gcgcggagat ggccaaggcg gtggccgacg gcgaactggc cgcctacagc
    21121 gacctcaacg cccgcctgca ccgctgtgta cgtgacatcg ccggccacga gaccgccgac
    21181 cggctcatcg agcaactgag ggcccaggtg gtccggcacc ggttcatgct ctcccgtgtg
    21241 cccggccggg cccgtgcgtc gctgccccag caccagcgga tcatcgaggc gatcgtcgcc
    21301 ggtgaccccg cggaggccga ggccgccatg cgggcccata tcgccagtgt ggtcgaggcg
    21361 ctgagggccc tggagacgag caggaccgcg gagggctgag aggcttccgc atgtcaccga
    21421 ggtctccggc acgtccgacc acctccctag gggcggccca ccgccatggt gttctctccg
    21481 aagaggaccc tcgtctaccc gggccgtcgt ccggggaaca gccgtcagcc tcccgccgca
    21541 ccggcgttct ggaccgccct cctggcccag gcgatttcga gcttgcccgt cggcgtgcgg
    21601 ggcagcacgt ccgtcagcac gacggaccgg gggaccttgt aaccggcgag gctgcgccgg
    21661 acccagtcgc gcagttcctc gccggaggcg gtggcggccg gtccgaccgc gacgacagcg
    21721 gccacccgct cgccccatgt ctcgtcgggg acaccgacga cgacgcagtc cgtcacctcg
    21781 gggtgcgtca gcagcacatc ctccacttcc tgcgggtgga ccttctcccc gccggtgttg
    21841 atcacacccg agccgcgtcc gaggaacctg atcgcgccgt cggcctcgat ctgggcgaga
    21901 tcgccgggga tggcgtaccg cactccctcg atggtgcgga acgtccgggc gctcttcccg
    21961 gtgtccttgt agtaaccgag cggcatgggc ccgcagtagg cgaggttccc ggtctcaccg
    22021 ctgccgggct cgacgaaacg gtccccttcg ccgatcaccc tggccgcggg caccggacgg
    22081 aaccgggtcg gcaactcccg taccgacgag gtgacgccaa gggcgaaggg gccgccctcg
    22141 ctggaggcga tggcgtcgac gatcgtgacg tcggcgcgtt cgtgcagcgc tttcttcagc
    22201 cggtcgtcga gcgcggtgcc ggagctgatg accgtgcgca gggtacgcag gtcgtacggt
    22261 gtgccggtgc cttcggcacg caccagttcg tcgacgagcg gccggcagac ggcgttgccc
    22321 gcgacgagca gcgtgtcgac ctcgcgctcg gcgagcgtct gccagacgtg gaccggatcc
    22381 agtccgcccc gccgtgccat gaccgcccgg ccgcccacca tcagggtccc catggtgttg
    22441 aacagaccgg tggcgtgcat cagagggacg accggcatgg tggtgggcgc tctgccctcg
    22501 tggcgggcgg cgacggcggt cgacgcggct tcgtcgagcg ttttccacag ttcggtgacg
    22561 ccggcctggc ggaggatcgg gatgga
//
