LOCUS       NZ_CLHL01000007        22991 bp    DNA     linear   CON 30-NOV-2024
DEFINITION  Streptococcus pneumoniae strain SMRU2163, whole genome shotgun
            sequence.
ACCESSION   NZ_CLHL01000007
VERSION     NZ_CLHL01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001094205.1-RS_2024_11_30
            Annotation Date                   :: 11/30/2024 00:46:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,213
            CDSs (total)                      :: 2,163
            Genes (coding)                    :: 2,009
            CDSs (with protein)               :: 2,009
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 154
            CDSs (without protein)            :: 154
            Pseudo Genes (ambiguous residues) :: 0 of 154
            Pseudo Genes (frameshifted)       :: 68 of 154
            Pseudo Genes (incomplete)         :: 85 of 154
            Pseudo Genes (internal stop)      :: 43 of 154
            Pseudo Genes (multiple problems)  :: 34 of 154
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:27:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 43615
            Orig. end                         :: 66606
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CLHL01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22991
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22991
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12991](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12991)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    207..219
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    260..275
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    1079..1090
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            1375..1788
                     /gene="ndk"
                     /locus_tag="AE723_RS05705"
                     /old_locus_tag="ERS021673_01111"
     CDS             1375..1788
                     /EC_number="2.7.4.6"
                     /GO_function="GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ndk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /locus_tag="AE723_RS05705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01111"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_000438289.1"
                     /transl_table=11
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEEL
                     IDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRG
                     DFAKAAGENEIIQNVVHGSDSEESAKREIALWF"
     misc_feature    1377..1390
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.04"
                     /tool="antismash"
     gene            complement(2717..3349)
                     /locus_tag="AE723_RS05715"
                     /old_locus_tag="ERS021673_01113"
     CDS             complement(2717..3349)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /locus_tag="AE723_RS05715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01113"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000571415.1"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLAYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA
                     SIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            complement(3351..4118)
                     /locus_tag="AE723_RS05720"
                     /old_locus_tag="ERS021673_01114"
     CDS             complement(3351..4118)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /locus_tag="AE723_RS05720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01114"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_050116028.1"
                     /transl_table=11
                     /translation="MSQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRISSQDE
                     RQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAVQNY
                     VLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIATSIL
                     LFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEIGVA
                     FLVLLLFTGLSLLQLHVQMQKENKMSILVLKGD"
     gene            complement(4169..5908)
                     /locus_tag="AE723_RS05725"
                     /old_locus_tag="ERS021673_01115"
     CDS             complement(4169..5908)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /locus_tag="AE723_RS05725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01115"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000699969.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.5e-38, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESF
                     SESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVN
                     SESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESY
                     KLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQD
                     RLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIIN
                     LSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLK
                     LISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLS
                     ELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNY
                     MFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERI
                     QTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAK
                     KSK"
     gene            complement(5932..8040)
                     /locus_tag="AE723_RS05730"
                     /old_locus_tag="ERS021673_01116"
     CDS             complement(5932..8040)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /locus_tag="AE723_RS05730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01116"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000701298.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.3e-38, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRSG
                     YSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYILDP
                     AKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFFVTA
                     LLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVASLKYI
                     MDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDLLMIVV
                     YAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITSEVISKN
                     SDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLTLIVGVNI
                     KTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNTKSELIPER
                     VSQDIKFDKKIELKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSGKSTLAKILL
                     GLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTFGHFVSDEELM
                     TNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKPSVVVLDEATSS
                     LDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEIGTHRELLELGGI
                     YKQLYSNN"
     gene            complement(8037..8966)
                     /locus_tag="AE723_RS05735"
                     /old_locus_tag="ERS021673_01117"
     CDS             complement(8037..8966)
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /locus_tag="AE723_RS05735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01117"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_000912954.1"
                     /transl_table=11
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISIT
                     LHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKNSD
                     RNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAIREI
                     VLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVKGEGS
                     AFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSKNNKYL
                     EKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            complement(8947..9651)
                     /locus_tag="AE723_RS05740"
                     /old_locus_tag="ERS021673_01118"
     CDS             complement(8947..9651)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /locus_tag="AE723_RS05740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01118"
                     /product="flavodoxin family protein"
                     /protein_id="WP_001033170.1"
                     /transl_table=11
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNSE
                     LEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFIER
                     IGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKDIAE
                     AQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRLFEAN
                     SLEEWYYVENIK"
     misc_feature    complement(9788..9801)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.84"
                     /tool="antismash"
     gene            complement(10001..12991)
                     /locus_tag="AE723_RS05745"
                     /old_locus_tag="ERS021673_01119"
     CDS             complement(10001..12991)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /locus_tag="AE723_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01119"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_050150229.1"
                     /sec_met_domain="DUF4135 (E-value: 2.1e-91, bitscore:
                     299.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2e-52, bitscore:
                     170.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSIIS
                     EKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKHPQ
                     RINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPWIVK
                     PLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESCLRFY
                     TYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKIVYKPK
                     NLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKKLPEYYYNF
                     GVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDTLFHRVTR
                     TLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKIDFEGGKNL
                     PVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTRVLFRDTNSY
                     ASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDIPIFYTDTNIN
                     EIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSFDQRKKGYKLNL
                     SNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGSKWCLEQTGNDMY
                     RGSAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGLTGDIGYFIVLSII
                     EDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINTLVRYYRRGIEKERV
                     LRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKVTRLKKYKELILQLVP
                     REKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGSMAIINFYIDYMKEMDT
                     SMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIAYTFLRYIALNQNDKKIV
                     IPSLLEI"
     gene            complement(13108..13296)
                     /gene="pneA2"
                     /locus_tag="AE723_RS05750"
                     /old_locus_tag="ERS021673_01120"
     CDS             complement(13108..13296)
                     /codon_start=1
                     /gene="pneA2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /locus_tag="AE723_RS05750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01120"
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="WP_000786759.1"
                     /transl_table=11
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFIA
                     SYLGSAQTRCGKDNKKK"
     CDS_motif       complement(13222..13296)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNDFVIGKSLKELSLEEMQLVYGG"
                     /locus_tag="AE723_RS05750_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13108..13221)
                     /prepeptide="core"
                     /locus_tag="AE723_RS05750_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="3743.2"
                     /monoisotopic_mass="3741.0"
                     /core_sequence="TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNDFVIGKSLKELSLEEMQLVYGG"
                     /leader_location="[13221:13296](-)"
                     /alternative_weights="3761.2"
                     /alternative_weights="3779.2"
                     /alternative_weights="3797.3"
                     /alternative_weights="3815.3"
                     /alternative_weights="3833.3"
                     /alternative_weights="3851.3"
                     /alternative_weights="3869.3"
     gene            complement(13303..13527)
                     /gene="pneA1"
                     /locus_tag="AE723_RS05755"
                     /old_locus_tag="ERS021673_01121"
     CDS             complement(13303..13527)
                     /codon_start=1
                     /gene="pneA1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /locus_tag="AE723_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01121"
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="WP_000181087.1"
                     /transl_table=11
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIILK
                     SAAASSKVCISAAVSGIGGLVSYNNDCLG"
     CDS_motif       complement(13441..13527)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /locus_tag="AE723_RS05755_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13303..13440)
                     /prepeptide="core"
                     /locus_tag="AE723_RS05755_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="4315.8"
                     /monoisotopic_mass="4313.2"
                     /core_sequence="SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDC
                     LG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /leader_location="[13440:13527](-)"
                     /alternative_weights="4333.9"
                     /alternative_weights="4351.9"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
                     /alternative_weights="4424.0"
                     /alternative_weights="4442.0"
     gene            complement(13630..13800)
                     /locus_tag="AE723_RS13230"
                     /old_locus_tag="ERS021673_01122"
     CDS             complement(13630..13800)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /locus_tag="AE723_RS13230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01122"
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_001227862.1"
                     /transl_table=11
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQK
                     KSNGLDVGKAD"
     misc_feature    13783..13798
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            13992..14855
                     /locus_tag="AE723_RS05765"
                     /old_locus_tag="ERS021673_01123"
     CDS             13992..14855
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="AE723_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01123"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001093620.1"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYDDLEYIYRIEIERSTF
                     LTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     misc_feature    14892..14909
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    14955..14968
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            15238..15858
                     /locus_tag="AE723_RS05770"
                     /old_locus_tag="ERS021673_01124"
     CDS             15238..15858
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /locus_tag="AE723_RS05770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01124"
                     /product="hypothetical protein"
                     /protein_id="WP_000839908.1"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            15944..16387
                     /gene="tsaE"
                     /locus_tag="AE723_RS05775"
                     /old_locus_tag="ERS021673_01125"
     CDS             15944..16387
                     /GO_process="GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /locus_tag="AE723_RS05775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01125"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_000288232.1"
                     /transl_table=11
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            16377..16895
                     /locus_tag="AE723_RS05780"
                     /old_locus_tag="ERS021673_01126"
     CDS             16377..16895
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /locus_tag="AE723_RS05780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01126"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_050116027.1"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADRRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLIG"
     gene            16903..17919
                     /gene="brpA"
                     /locus_tag="AE723_RS05785"
                     /old_locus_tag="ERS021673_01127"
     CDS             16903..17919
                     /codon_start=1
                     /gene="brpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /locus_tag="AE723_RS05785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01127"
                     /product="biofilm formation/cell division transcriptional
                     regulator BrpA"
                     /protein_id="WP_000239282.1"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     misc_feature    17963..17976
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     misc_feature    17964..17977
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     gene            18003..19259
                     /locus_tag="AE723_RS05790"
                     /old_locus_tag="ERS021673_01128"
     CDS             18003..19259
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /locus_tag="AE723_RS05790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01128"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_000642704.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDN
                     EVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFA
                     LRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLN
                     QLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTK
                     ASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAA
                     AESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQK
                     MAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADV
                     RHIAVMHAFNLVRKALLSD"
     gene            19314..20480
                     /gene="recA"
                     /locus_tag="AE723_RS05795"
                     /old_locus_tag="ERS021673_01129"
     CDS             19314..20480
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /locus_tag="AE723_RS05795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01129"
                     /product="recombinase RecA"
                     /protein_id="WP_001085462.1"
                     /transl_table=11
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGER
                     AEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAA
                     FIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALV
                     PRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETT
                     PGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMY
                     GEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQV
                     RSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE"
     gene            20787..22157
                     /locus_tag="AE723_RS05800"
                     /old_locus_tag="ERS021673_01130"
     CDS             20787..22157
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /locus_tag="AE723_RS05800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS021673_01130"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_001036271.1"
                     /transl_table=11
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVGR
                     FLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWILGA
                     LLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLRSIG
                     DSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRKSVPE
                     LLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQTAARR
                     IMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIFLFFASP
                     ALVSFLASSTDGYLIENGSLYLQISSTFYPILSLLLIYRNCLQGLGQKILPLVSSFIEL
                     IGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAILATKVQS"
     misc_feature    22700..22714
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
ORIGIN
        1 cgacgttgcc caagacgtta tcatccgtga ggacgactgt ggaactgacc gtggtctctt
       61 gatccgttct atcgcagaag gaaaagagat gatcgagtct ctcgaagagc gtctcaacgg
      121 tcgttacact aagaaaactg ttaaacatcc agaaactggt gcagtgatta ttggtccaaa
      181 tgaattgatt acagaagaca aggcgcgtga aattgtcaat gctggtgtgg aagaagtgac
      241 tatccgttct gtatttacat gtaacactcg tcacggtgtc tgccgtcact gttacggtat
      301 caacttggcg actggtgatg cggttgaagt tggtgaagca gttggtacaa tcgctgccca
      361 atctatcggg gaacctggta cacagcttac aatgcgtacc ttccacacag gtggggttgc
      421 ctcaaatacc gatatcactc agggtcttcc tcgtgtccaa gaaatctttg aagcccgcaa
      481 tcctaaaggg gaagcggtta tcacagaggt taaaggacaa gttactgcta tcgaagagga
      541 tgcatcaact cgtaccaaga aagtctttgt taagggtgaa actggcgaag gtgaatatgt
      601 cgttccattt acagctcgta tgcgtgtcga agttgggggc caagtagcgc gtggtgctgc
      661 tctgacagaa ggttctatcc aaccaaaacg tctccttgca gttcgtgatg tcttgtcagt
      721 tgaaacgtac cttctcggtg aagtacaaaa agtttaccgt agccaagggg tagaaatcgg
      781 tgacaaacac atcgaggtaa tggttcgtca aatgatccgt aaagtccgtg tcatggatcc
      841 aggtgataca gatcttctca tgggtaccct catggatatc aatgacttta cagatgccaa
      901 caaagatgtc cttatcgcag gtggagttcc agcgacaggt cgcccagtcc ttatgggaat
      961 taccaaagcc tcacttgaaa caaacagttt cttgtcagcg gcttccttcc aggaaacaac
     1021 tcgtgtcctt actgacgcag ctatccgtgg taagaaagac catctccttg gacttaaaga
     1081 aaatgttatc atcggtaaga tcatcccagc tggtactggt atggcccgtt accgtaacct
     1141 tgaaccacat gctgtcaacg aagaagaata ccttaatcct ccagtagagg aagaaggaaa
     1201 tgaagaaaca acagaagtag ttgtggatac tgccgttgaa actgtggaag aaacagtaga
     1261 ataagagaga atgagagaac ccgagggttc tctcattctc tcttctgaaa actttctcca
     1321 tttttccacg aaatgtggta aaataaaaga aagaagctga caaaggagac gggtatggaa
     1381 caaacattct ttatcatcaa accagatggt gtaaaaagag ggctagtggg tgaagtgtta
     1441 aagcgcatcg aacaacgtgg atttacaatc gaaaaattgg agtttcgttc acaggtttca
     1501 gaagagttga ttgaccagca ctatcaggac ttggttggtc agagttttta cccaccgatt
     1561 cgtgaattca tgacttcagg tccagttctt gtgggtgtca tttctggtcc caaagtaatc
     1621 gaaacttggc ggaccatgat gggtgcaact cgtccagaag aagctttacc aggcactatt
     1681 cgaggtgatt ttgcaaaagc tgctggagaa aatgagatta tccaaaatgt tgtacatggt
     1741 tcagattcag aagagtcagc taagcgagaa attgctcttt ggttttaaga gtggattggc
     1801 tcaatcaatt ggttaaaagc tcatttgaat agaaagtata gtcaattagt ttaagacatg
     1861 acgcatgata tcaaactttt tagtttttga tatggtgcgt tttttgatta agtgactatt
     1921 agtttgtctc gctccgttag gtgcgagaca aaaaaaacac ccgctatgcg ggtgcgcgtc
     1981 gaaggttata ccaaaaaaac tccaaacgcg atacaataaa ggtgttcaat ccaattgtaa
     2041 agcgaaagga gaaaaatatg gcacaaaagg ttcttttatc ctgttcttgt ttcaattgac
     2101 tatatttcta tactttttct tcctttctct gtgaaaatcg caagtttttc ccaccttttc
     2161 tcaatactga aacaacatct ttccagaact tcaataattt ctttttgtgt taaatcatta
     2221 tttaactaaa tctttggagg caatacgttt tcaaagctac ttttttacca taggttttga
     2281 gccttcaaca cagattacta agccaaaaat gctctaaatt tttgaaattc taacaaattc
     2341 cactcaactt tatcatcatc tttgactttc acaatatctt cctcaaaata acatggaata
     2401 aagatagttt tcttttaaaa cggttgtagg aggaaaatct ctcctacact attattgatt
     2461 ctgagagaaa attgcaaaat atcatctacc aaactttcaa ttattaagat tttttgcagt
     2521 ttatctgaat tagaatcgca aggcttctca ataatataat tgtcgaattt tttcattcta
     2581 acttcctctc cattatttct tcctttatca agaaaaagtt acctcaatat taataaagta
     2641 caattctaaa ttaactccaa ttcttgattc atgataatat ttcagtaact catcgtgcaa
     2701 ttaaaaacaa ggatttttat ttcagatgat ccatcgtgaa cacttcatca gccatctccc
     2761 aaattgccgg attatgtgtt gcgataatga ttagcctatt atcatctcga agagatagca
     2821 aaatctccat aatcaactga gaggttgctg ggtctattga agctgttggc tcatctgcca
     2881 gaataaaggg tggattcttt aagataattt ttgccaaggc aacccgttgc gattctccgc
     2941 ccgataactc aaagatgcgc ttatctaggt caagataagc caggccgacc tgttctaaag
     3001 cctgcttctg cctcaaccgc tgttccgacc gactcaactt ttgaccaatg agacctagct
     3061 taaggttttc ttcaatactt tggttttcaa ttaagccaaa gttctggaag aggtagccca
     3121 attcgtgacg gaaaaaatca ctcgatttat aattggccaa gtctttacct cggtaaaaaa
     3181 tcgtcccatc ataaggttct aatttcccaa tcatgttcat caaggttgtt tttccgctac
     3241 cacttgaacc aattaaggca tagacttttc cagcctcaaa tgtcattgaa agattcgaaa
     3301 ataactctcg ttctccaaaa gatttactca cctgtttaag ttcaatcata ttaatctccc
     3361 ttcaaaacaa gaatggacat cttgttttct ttctgcattt ggacatgtaa ctgtaaaaga
     3421 gatagaccag taaagagtaa caagactaag aaagcaactc ctatctctac ctgaagaaat
     3481 acactcgcaa caaatcccag taaaaacaca cccagttgag caaagagata agtgcgatgg
     3541 atttctaaga acctgagacc tgcaatgcgt ttgataaaaa tggcacgtct aaattcttca
     3601 aagtagagcc tattcatagt gttaaacaac aagattgaag ttgcaatccc aagcacagct
     3661 cctgctagca ttacccaacg ttccctctgg atattatcca ataatgtgat gtagttgtgg
     3721 taacctgttt gcatttctga gacccaattt tcaatgcctt gtctctggat aagctcctgg
     3781 gcatcagaca attgattaaa gagaacgtag ttctgtactg cgtctatcca aaacaaaatg
     3841 gactgtggac cagttgattg gggtgttata acaatgatga ttggatcttt caaaaactgc
     3901 tggtaagaaa taggggtcgt attatacaca aaacgatcct gacctgattc taaataacct
     3961 accgtagcag tcatttgctg tcgttcatct tgactagata tgcgactggt taagtcgtct
     4021 tcaaaaacag atttataatg ttcttcctct gaacggaggt gttcaggcag caataagaca
     4081 aactccccta catcaaggtg attcatcttt tgactcattt tagttgaact gtaggactta
     4141 ctttttcaga gggctccaaa ttttattttc atttactttt tttagcccat aaaatattta
     4201 ccatacttat aaaaagtagt aatactccaa ctaaactgac ttgtaatgaa ttatatgtat
     4261 tttctgaagt gttaggtaaa taattttgag agtacccttc tcgggcaata gtaataatat
     4321 tgtgtgtgtt tatttgttta attccaatag tagtttgaat tctctcttcc aactcaatta
     4381 aattaacatt atctatgaaa ctatcccaac tttgttcatt tttatattct aattgtaaca
     4441 tattcaaatc atatctcaat acgtttggta tatttaacac ttttatacca ttttttactg
     4501 gtaatgtttc ttccagaatt ttttttacaa acatataatt atagggctga tcttttaatt
     4561 tgtatttatc aataatcatt gcaatcgcac cagaaacttt aggagcagca aatgagtttc
     4621 cataaagata cgtatatcct cctagtgttg ccgaaaaaat ccaatcttct ttatattttt
     4681 ctgcattaat aaagttatta agtcctaatt ctgaaagaga taatgttgag cctgcaggcg
     4741 catatattgc atcagaatcc cctttattgc taaaatctga taaattacct aagcgatcta
     4801 tgcctccgac cgaaattgta gatgagaaat aacttggaac atcaactact aatcctggtt
     4861 ttcttacttt tttgcgtgaa ctaataagtt tcaataaatc tgactgattt gatacattta
     4921 gggagtcatt ccctaatgca gctactataa ttactccttt ttgattcgcg taatcaatag
     4981 cctttttata cttcaaaaat gtttcaaaat catttgttcc gtcctcatat tctccatcaa
     5041 tcattaaata ttgtccagta ctaagattga taatatcatt gccatcatct acagcatcaa
     5101 aaattgcttt tacaatccaa tctggactag ctgacgactt accaaatatt ctatagacgt
     5161 taatattaac gtgaggattt actccattaa tattgtcatc ccctacaatt tgagctacaa
     5221 cagccgtacc atgacctaat ctatcttgaa tatctgatat tattccttcc tctccctcct
     5281 cttttcctaa atatccttta ttggggacat agttttttga gtgatttgaa agatttttca
     5341 gtaatccagt attttgtaaa tcgactcctg aatctaaaat agcaattgaa actttagaat
     5401 tacttttaga atataattta taactttcgc ctccaccagt aactttatct atatcccatt
     5461 catattttct tacaatcgac gattctaagt tatctttgtc atgctctata tttcctcctc
     5521 tattatctag atgagaaaca ttttccttaa ttttattatc taaattatct tcgcctagta
     5581 aattattact ttcagagtta acaatatcgt tatttatttg tggttcaagt tccaatttac
     5641 aacagttttt ttctaaatgt ttatctgttg ttacaaataa ttctgtctta tcgatttgaa
     5701 tacgaaattt attttggtct acttcttctt gatttttatt agaatagtca acctgttttt
     5761 catcagattc agaaaaactt tcgctagtct gagtgtgagt tatattgcca tcaagatttt
     5821 taggtatttc ttgagcagta acagaattat tgaacaaaca aaagaataat atcgctaaag
     5881 tccaatattt ttttttcata atcttcataa atttaccctt ttaatcaaaa actaattatt
     5941 tgaatacaat tgcttataaa tgcctcctag ttcaagaagt tctctatggg tcccaatctc
     6001 tacaatttca ccattatgca ttactaagat cttatctgca gacttgatag tatctagtcg
     6061 atgggcaatt aaaatcttag tggtaccgat ttcacttaag taagaagttg taatttgttg
     6121 agataaatta tctaaactac ttgttgcttc gtccaaaaca actaccgaag gtttcgacaa
     6181 aagacaacga gctaaaagta tcatttgctg ctgccctcca gaaaagttat taccttcttc
     6241 agcgatgatt gtctctaatc caagaggtaa agatttaact acattgctaa gaccaattga
     6301 atttagattt gtcattaatt cttcatctga aacaaagtgt ccaaatgtca aattctctct
     6361 taaggtacca taacttaggg ttgaattttg taacactgct ccaaaaatct ttctatacaa
     6421 tgtttgacca atttcttctt tttctactcc atcaacttct attgaaccaa tattaggttc
     6481 taataaacct aataaaattt tagctaatgt actcttacct gaacctgatt ctccaacaat
     6541 agcaacagtt tctccttttt taatagtaac atttattcct ttcaaaacat aatcatcaaa
     6601 taatccatat ttataccaaa tatcttttaa ttctattttt ttatcaaatt ttatatcttg
     6661 actgactctt tctggaatta attcggattt agtattaaac acatcctcta ttcttaaaaa
     6721 atatcccttt aataacatta attgtatata gttatcactt aaagaaatta taggagaaat
     6781 aaagtatggt gagactgtac ttattgctac aatttgtcct aacgtcaatt gttcgaatgt
     6841 ttttatattt acacctacaa taagggtcaa aacagggaga ataatttgta aaacattcgt
     6901 tatactacta acaattgata aatgtatatc aagttttcga cctatgatga gctgttttgt
     6961 attaaaatta tcccatttgt taatccaaaa ttcctcttct ccagttagct taatatcact
     7021 atttttagaa attacttcgg aagtaatatt ttgaacatta accttttctt ttatattttt
     7081 atcaattaaa ttttttgaga tttttatgat tggatacatt acaatagata gagctagact
     7141 tagtgatatt aaaaagatta ccatgtactt agaaaagcta aataaaacca cagcataaac
     7201 cacaatcatt aacaaatcaa gtatagctgc tataaaatta tttgatagta tttctcttat
     7261 ataaacaata gagttagctc taaaaagtat atcccctaaa gtacgttttt cataaaaact
     7321 gtaaggtaaa tatatcaaat gtttcataaa atcatagcta atctctttat ccattatata
     7381 ttttaaggat gcaacatata tctgtcttaa taaatacatt agtgagaatg aaacagtaaa
     7441 tataaataat atagtaaata acattctaga cgaatacgaa tcgtccttga aattcgtgtc
     7501 aattatgtat ctattagcta taggtactaa tgattgtatt acatacaata atgctgttac
     7561 aaaaaataaa atccctagct tattcctata cttaaaaaaa tactttaaaa caggcgactt
     7621 cttattatct ttacgagaca taaagctatc taacttttta aatgttaaaa tgatatttga
     7681 ataatgcctt tcaaattcac ttattgacat tctctgcctg ccttttgcag gatctaaaat
     7741 ataaaacttg tttttactaa ttttttcaag aataataaaa tgagaactct cccagaagca
     7801 aatgagtggg aaactgagcg gttttaaatc tcttaccgaa gctttaaaag catgagaact
     7861 tatattaaaa tctcctaaaa ctttacttat agataggaga gaatatccag atctggatga
     7921 tgggtagatt tcacgtagtt catttaaaga aatctcatat ttaaaatagt tcaatatcat
     7981 ggcacagcat gctaatccac attctgaatt ttccatttga tatatcattg gaattttcac
     8041 aatacttcct ccttgttcaa aataaagtcg ataatttctt cttgtctaaa atctactaat
     8101 ttctttagat acttaatctt ttctaaatat ttattatttt tcgagtaaat atagtttgac
     8161 aaggtaaaaa caacttcttc taaagataag ttctgtggaa taatccaatc agaagattta
     8221 tgtagtaatt tatagtactc atggataata ttttcctgaa tatttgaatc aaaaacttca
     8281 tgattagcaa ttgtaaatgc tgacccttca cctttcactt caaagtaaag gtttatcaaa
     8341 catttttcaa attttgaaaa aaaagatttt tctttagagg ttaattttgc aaaatcgtcg
     8401 attgttatat aaggattatt atagagactg ttcgcaaaga atctctgata tgtttttgaa
     8461 tcttttgaat acaaaactat ctctctaata gcattgccat ctgttccatc aattggtaaa
     8521 cataccgtaa ctagaaaaag aattatattc aaaataaaaa attctgatgc gtacggcaca
     8581 aatcccaaaa gtgctaatat tgcgacaatt aggttagctc cacctccccc aaagaagtag
     8641 aacaccaaat tcctatcact atttttttca ttagtaatgt ttctattact catttgacaa
     8701 taaccgaatg ctaataacac tggaaatttg aaatatattt tttttctgaa atagaagaaa
     8761 aagggagtag caagcatctc tagtttataa gataaacatc ttcccactaa aaaatgacct
     8821 agttcatgta atgtaattga tattaacgaa attaaaatca atcgaaaata atagattaat
     8881 gaatcatttg gaaaaattat caataatagg aacaataacg gaatcaaaca taaatatatg
     8941 acagagttat ttaatatttt caacataata ccattcctct aaactattag cttcaaaaag
     9001 gcgttttttc tcccaataca tcttctcaaa atgttcggaa tcataatttt ctaaaattaa
     9061 ttttaatgtc tggtaagctc tttcttgata atccgttgtt ttgtacttaa ttttcccttc
     9121 aagtacatct tcaattttat aagttgcctc catcaactga gcctctgcaa tatctttgag
     9181 tgaattggta attgaaactt ggtgtaatat ctgtcctccc atatatgaaa atatatctct
     9241 aagatattct gacacattat cagagccgtt actctcagca acatctaatg ttacaacaaa
     9301 ctttccagct aatcgaaaaa gatggctcca ccccccaatc ctttcaataa agttttttgt
     9361 gtccacagat acgttttgta aatatacagg agaagagata attataatat cagactctaa
     9421 taactctttt tttataacac ctccatcatc agcattactt tgcctatcaa ttcctttctt
     9481 aaacaactct tctgaatcag aattagatat ttctagctct gaattgaaag gtgtcctgaa
     9541 agatatatca acattatttc tactagaaat gatacttgaa agtctcttag tatactctaa
     9601 agtcttagag ttatgatttc gcactcctgc atatataaat attttattca ttttaattca
     9661 tcctctcaat ttgaatttag tagatttttc aagatagtat ggtacaaaaa cagacttttg
     9721 ttgactcaca ttattacata tgttttgtat taaaccaaaa tcaatactat ttttggagta
     9781 attttgattt tagtttaaaa tcatttctat aacagtagca tatacctcaa gccgtttagc
     9841 aattagaata gaacctttct ttattatatt attatctcaa tgaaaagcta cactattaaa
     9901 aatattttat agaattacat attaaactag tcaatcttgg tatttttata ttgcttaatg
     9961 agtggacacc tctattttag aaacaaaact ataaattaag ctagatttca agtaatgagg
    10021 ggataactat ctttttgtca ttctgattca gtgcgatata ccttaaaaaa gtataagcaa
    10081 taccagtcac acctgtatac aaagaaaaat ctgggaaatt gcttgtttgg acgatacgat
    10141 actctccttc ttttgattta ttcattacaa cactacacaa taaagactcc aattccatac
    10201 tagtatccat ttctttcatg tagtcgatgt aaaaatttat tatggccata cttccatggc
    10261 aaaatgtatc attatctaaa ctagctacaa ttccctctgg aacactttgg ggatgattaa
    10321 ctaatgtccc aaattctcca ctacaccact tcaaagaatg aattttgatt ttctccctag
    10381 gaactagttg taaaattaat tctttatatt ttttaagtct tgtcacttta taaatatttt
    10441 ttaatgtaaa aattacacct gatagtccat ggccaaaact atatccaaaa ttactattat
    10501 ctctctcgct tacatcatta tatagcgtat cacctaaact taatactagc cttagaacac
    10561 gttccttctc tattcctctc ctataatatc ttaccagtgt attaattaaa ggtagaagac
    10621 cattaatata gtcagacttg tttgaaacac ttgcaaaatc agtcttttca agctcagtta
    10681 aaacactctt tatataattt aagcatgcga gagtatttgt atcgtaatcc tctataatgg
    10741 atagaacaat gaaatatcct atatccccag ttaaaccaaa tgtggtctta gataaagaaa
    10801 cagatggcgg aattgcagat aacattttat tgtacagttg agtatatgat gatttatctt
    10861 tcaataattt tacatagtac ataaacagta atattccagc actaccccta tacatatcat
    10921 tacccgtttg ttcaagacac catttagaac ctttaaaatt aacaggtata ctccaaattg
    10981 gatattcgtc ataaatatta ttaataacca aagagtctgc aatattttct acttcattat
    11041 gcagaatagt aactaaactt tcatttggga gtttttttct attagataag tttaatttat
    11101 atcctttttt tcgctgatca aagcttggaa aataaatttc aatgatatca agttgctttt
    11161 ctaaattttc caaattatta ttaggtaaat atttcataaa atagtcatat ccagaaaatt
    11221 gatgtaggga aataaaatga tttccaaaat catcgtagat ttcattgata tttgtatctg
    11281 tataaaaaat cggaatatct aataacctca tttgttcaca ttcgcttgct acaatacctt
    11341 gattagaaaa cttattgctc cagagatttt ccaatgcttt ttctctatct aacatttctt
    11401 cataaaaatc aggatgatat aaaaaagata gtactgaagc atagctattt gtgtctctaa
    11461 aaagtaccct tgtctttaaa ccatacaagt ttgcttttaa tagcatttta aattcttctg
    11521 ttttatttaa ctcttcaaat atcagataaa aatccctaaa accttttttg aaatctttta
    11581 tatacttatc aaattctata tcaccatccc gaacaggcag gtttttccca ccttcaaaat
    11641 caattttccc aatatcaaac tttaccttat cagtatttaa attaattaaa acttgaccat
    11701 taaaagcatc cttcttaaaa tttcctgtaa gagcactcat ctcaacatca agaccatcct
    11761 ccctttttac tccctctgtt ggaagaagca aagttcgagt caccctgtga aacagggtat
    11821 ccagcaaact ctgaccagtt ttatcatcaa atagaggttg ctgtaacatt gtttcaaagt
    11881 ctattattac aggcatatct ccataggaaa ttaaattttc aaaatgtata tcactcccat
    11941 taaataaata tataaatgct aaaagcacac caaaattata ataatattca ggtaattttt
    12001 tcttttgctc tagaggtaga taatcaataa attcttcata gctgtgatcc gaataagcaa
    12061 tagttcgagg tattcttatc ctaatttttt catcaacctt tcggatatac tcagcaatag
    12121 tatttagtga gttattgatt attaaatttt taggcttgta aacaattttc gcgtcatcaa
    12181 agaagagtat caaaacagtt tttccttggc tgtgtgtatc accctttcca aattttatat
    12241 catttaattt cccccttagc cctaattctt cttctagcac actaaaatca ttttctaaat
    12301 ttgataaaat ttctataaaa taagtataga accgaagaca agactccgat atttgcctca
    12361 gtaaaacggg atatttgtta taaaaattta atatattctc ttccttgtca aacaatgtta
    12421 taaaatattt gtaccgttgc tgctccgatt ccccttcaag taaacctttt tcacgcaatg
    12481 aatttatctc taaaaccaaa ggtttaacaa tccaaggata gattaaatct tctaaataaa
    12541 atactagaga ggaaaaaata tttccattct tgtcaatcca ctcgtattct ttattctcta
    12601 gataattatt gattaattta agcaaattaa taataaaggg ttccaaaatt ctagaaaaat
    12661 ctttcttaaa attaattctt tggggatgtt ttctaaatat ttcaaatgaa ccctccgcaa
    12721 atttatacca ttccgaattt ttggcatatt ctgaatatag tcttatctgt tcctcggtat
    12781 aatcatagtt cacagtgtta gaaaatattt ttttattgta attatttaat ttcaacattt
    12841 cttcaaaagt tttttcagaa ataattgaca ttgtagaacg ccaattattt aatgaaaagt
    12901 tatttaagga attatcattt cgttcagata atatttgata tctttcctta ataaacaatg
    12961 ttttatgcac atttttaatt ttatatttca tttacttacc tcaaacctat acgacttact
    13021 attgttttaa aaaaaaaacc tctctcaaaa ttattagtta cgagagagga aaataaagag
    13081 caacttttat ttttaaaatt gaatatttta ttttttcttg ttgtctttgc cacaacgagt
    13141 ctgagctgac cccaaatatg atgcaataaa acttaatgta gcagaacata taattgttga
    13201 tctagggtca gcaccatctg tgccaccata aaccaattgc atttcttcaa gagataattc
    13261 tttcaaactc tttccgatta caaaatcatt tttcatttta atttacccca aacaatcatt
    13321 attgtagcta actagccccc caataccaga aacagctgca ctaatgcata ctttcgagct
    13381 agctgcagct gatttcaaaa taataggagt aggcgtccaa cgtggctctg caccatcaga
    13441 tgcaccataa attaaactca tttcatcagc agacaatgat tttaaacttt ttccacaaaa
    13501 tttttcgttt gaattaaagt tggtcataag taataactcc tccttataaa aagttaaata
    13561 agttgctcta tatttttcgt tttttcagat aaattataat tctctcattc tcgtgcaaaa
    13621 tatcgggttt taatccgcct tcccaacatc aagaccattg gacttctttt gcgattgcac
    13681 tcgaatctcc aattgtttat tcttctgaat aaactgttgg taaggaattg tattactaaa
    13741 cataaaaaca cctagcaatg caaatgtaac taatttttta attccacgtt tttttctcat
    13801 gcaatgaaac ccctttcttt ttccttgttt ttattctaac agatatattt tatttagtca
    13861 agtattttta tgtaattttt aacttttttt tttgtttatt accataaaga attatttatt
    13921 cctttaactt gctattttga actaaaaact ttataatgaa attaagcaaa taggaaggtt
    13981 tattatcttt aatgaataca ctcgcagaga aattcagatt gaaaagaaaa gagttgagac
    14041 tctcccaaca aactcttgca gaaggaattt gtgaacaaag tcagattagt aaaattgaga
    14101 gagggcattt cattccctcc gcagaccttt tgttcaaact ctctcaacga cttgaagtac
    14161 cattagatta tttttttaat gaacaaattg aaattaaatc taacctctct aatttcaagc
    14221 aattgtctgc tcgactatta gacgatagaa attatgacga tttggaatat atttatagaa
    14281 tagagattga acgaagtact tttctaacac tagaagaccg aacttacctt gaatggatta
    14341 aagctattat tgacttctat caatatgaca gtaagtgtga ggcaatttct tcattggaaa
    14401 atatattatt aaaagtctct tcaaatactc tgatttattt aaaggcgttg aatactctat
    14461 ctaatttcta ttccttagtg ggtcgtgaac aagaatatga ggcaaactac tctcatttaa
    14521 tagagttgta tcagacaaaa aatttggacc atcaagagtt tttatttggc tacatcagag
    14581 ttcgttacaa ctacgctcac tacctagtat caaaggaaaa atataatgaa gccatccaag
    14641 aagctcttga aacgattgaa ctctgtaaac aaagacagac aagctaccaa ttggctcctc
    14701 tacttattct tgtaggaaat gctggagcca aatttctaga cagagaacaa gtcaaaaatt
    14761 attatataga agcaagagag ttatgtaaga tttataacaa tcctttaatg ttgatgaaga
    14821 tagaaaatta tttgaaggaa ctagatactg tttagttaat cttgacatta tagtttttct
    14881 gaaacgttaa ataacctgta aggctgatag ttagattaat actatcagcc ttataattat
    14941 gtgactctga gtccgtctcg ctccgtgagg tgcgagacaa aacaaccacc cgtttgacgg
    15001 attttcatga tttcaaattt atattcttcg aaaatctctt caaatcacgt cagctctatc
    15061 tgcaatctca aaacagtgtt ttgagcaacc tgtggctagc tacctagttt gctctttgat
    15121 tttcattgag tattagtctc tagtgtttgt ttagcgtctt aaagagacat ttgagaagat
    15181 tagaaacagt tctctctttt ctcctagtat aatgattggt aggaagggag agagaagatg
    15241 aaatcaatga gaatcttatt tttgttagct ttaattcaaa tcagtttgag tagctgtttc
    15301 ctatggaagg aatgcatctt gtcctttaaa caaagtacag cttttttcat cggaagcatg
    15361 gttttcgttt caggaatctg tgctggagta aattatcttt atactcgtaa gcaagaagtc
    15421 catagtgtcc tagccagtaa gaagtcggtg aagctttttt acagtatgtt actcttaatt
    15481 aatttgttag gagctgttct tgttttgtca gataacttgt tcatcaaaaa tacgctgcag
    15541 caagaattag ttgacttttt attgccatcc ttctttttcc tatttgggct agatttgctg
    15601 atttttttac ccttgaaaaa atacgtgcgc gattttcttg ctatgctgga cagaaaaaag
    15661 acagtgttgg tgactatttt agcaacactt cttttcttaa gaaatccaat gaccattgtc
    15721 tcacttctga tttatattgg actgggcttg ttttttgcag cctatcttgt cccaaattcg
    15781 gttaagaagg aagtttcctt ttatggtcat attttccgag atcttgtatt ggtcattgtt
    15841 acgctcattt tcttttagag aaagcctgtt ttttatggat gttatgatga taagtttagt
    15901 aggaaaatag acacaaaaga aaagtttttg gtataataag agtatgtaca caaaaaatga
    15961 agaagagttg caagccttag gggagcgttt gggccatcta ttagcaaaga atgatgtttt
    16021 aatcttaact ggagaactgg gtgcaggtaa aacgaccttt actaaaggac ttgcaaaagg
    16081 attacagatt tctcaaatga ttaaaagtcc cacctatact atcgtgagag agtatgaagg
    16141 tcgacttcca ctttatcacc tagatgttta tcgtattgaa ggagatgctg attctatcga
    16201 cttggatgag tttatctttg gtggcggcgt gactgttatt gagtggggaa atctcttagg
    16261 agatgccttg ccagatgctt atttagaatt ggaaattcta aaagaagcag atggacgccg
    16321 tttaaatttt caggcaaagg gtttgcgtgc tgagaaattg ttagaggagc ttcaatatgg
    16381 agtatgaatt gctcattagg gaagcagagc ccaaagatgc agctgaatta gtggcctttt
    16441 taaatcgtgt gagtttggag acagacttta ccagcctaga cggagatggt attctcttga
    16501 ctagtgagga gatggaaata ttcctcaaca agcaagctag ttcggacaat cagataacct
    16561 tacttgcatt cttaaatggc aaaattgctg gtattgtaaa tattacagct gatcggcgta
    16621 agagagtccg tcatattgga gatctcttca ttgtgattgg aaaaagatat tggaataatg
    16681 gcttgggaag tttgttgcta gaagaagcga tagagtgggc acaagcaagt ggcattctgc
    16741 gtcgtctcca actgactgtc caaactcgta atcaagcagc agtccatctt tatcaaaagc
    16801 atggctttgt cattgaaggt agccaagagc gtggggcata tatagaagaa gggaaattta
    16861 tcgatgttta cttgatgggt aaactgatag gttagtagaa atatggttaa aaaaattatt
    16921 ggaatggtgc tagctttact ttctgtaact gtagtaggag taggtgtttt tgcttatact
    16981 atttatcaac aagggacaga aaccttagct aaaacctata aaaaaatcgg cgaagaaacc
    17041 aaggttattg aagcgactga acctctaacc attctgttaa tgggagtgga caccggaaat
    17101 gttgaacgaa ctgaaacttg ggtcggtaga agtgatagca tgatcttgat gacagtgaat
    17161 cctaaaacga aaaaaacaac aatgatgagt ttagagcggg atattctgac gcgcattgaa
    17221 tcagggaatg gtcaggctca tgaagcgaaa ctgaactcag catatgcaga tggtggagca
    17281 gagcttgcta tagaaaccat tcaaaaaatg atgaatatcc atattgatcg ctatgtgatg
    17341 gtcaatatga gagggttgca aaaactagtg gatgcagtag gaggtattac agtcaataat
    17401 atcctaggtt tcccaatttc tatcagtgac caagaagaat ttaatactat ttctatcggt
    17461 gttggggagc aacatattgg gggagaagaa gccctagtct atgcacgaat gcgttaccaa
    17521 gatcctgagg gggattatgg tcgtcaaaaa cgtcaacgtg aagttattca aaaagtcatg
    17581 gaaaaagctc tcagtttaaa tagcattggt cattatcaag agattctaaa agctttgagt
    17641 gacaatatgc agaccaatat tgatttgtct gcaaaaagta tccctaactt gctaggctat
    17701 aaagattcat ttaaaaccat tgaaactcag cagttgcagg gtgaaggaga gatacttcaa
    17761 ggtgtttctt accagattgt ttcgagagca catatgttgg aaatgcaaaa tatactccga
    17821 cgttctttgg gacaagaaga agttactcag cttgaaacca atgcggtttt atttgaagat
    17881 ttatttggca gagcacctgt tggtgatgaa gataattaac ttttgataca aataaaaaat
    17941 caatcgtagg aaaattcctg cgattttttc aaaaaaatac gaatagatag gtaggaggaa
    18001 acatgaaagc agaaatcatt gctgttggaa cagagatttt gacaggacag attgtcaaca
    18061 ccaatgccca gtttttgtcg gaaaaactag ctgagattgg ggtagatgta tattttcaga
    18121 cggctgtagg agacaatgaa gttcgtctct tgtctttgct tgagattgcc agtcaacgta
    18181 gcagtctggt gattttgaca ggcggtttgg ggccaactga ggacgaccta accaaacaaa
    18241 ccctagctaa atttttaggg aaagcattag tctttgatcc tcaggctcag gagaagttgg
    18301 atatcttttt tgccctgcga ccagactatg cccgaacacc gaataacgaa agacaagctc
    18361 aaattgtaga aggagcgatt ccactgccaa acgaaacagg actggctgtt ggaggaaaat
    18421 tagaagtaga cggagtgacc tatgtcgtcc ttccaggtcc gccaagtgaa ttgaaaccca
    18481 tggtcttaaa ccaacttcta cccaagttga tgacagggaa caagctgtat tcccgagttc
    18541 ttcgtttctt tgggattggc gagagccagt tggttacgat tttggctgat ttaattgata
    18601 atcagatcga tcctaccttg gccccttatg ccaagacagg agaagtcact ctacgtctgt
    18661 caacaaaggc tagcagtcaa gaagaggcga atcaagcgct ggatatcttg gaaaatcaaa
    18721 tcttggactg ccagactttc gaaggaattt ctttacgaga cttttgctat ggttatgggg
    18781 aagaaactag tttagccagc attgtggtag aagaactgaa aaggcaaggg aaaaccatcg
    18841 cggctgcaga gagtttgacg gcaggtcttt tccaagctac cgtggcgaat ttttctggag
    18901 tttcaagtat atttgagggt ggttttgtga cctatagctt ggaggaaaaa tcaaggatgt
    18961 tggatattcc tgccaagaat ttggaagaac atggtgtggt gtctgaattt acagctcaga
    19021 agatggctga gcaggcacga agcaagaccc agtctgattt tggaattagt ttgactggag
    19081 tggcaggacc agatagccta gaaggacacc cagttgggac agtcttcata ggcttggcgc
    19141 aagatcaagg aactgaggtt atcaaggtta atattggagg cagaagccga gcagatgtac
    19201 gtcacattgc ggttatgcat gcctttaacc tagttcgcaa ggctttatta agtgactaac
    19261 ttttgatata atagtagata ggtctgagga tcattagaat gtaggagaat agaatggcga
    19321 aaaaaccaaa aaaattagaa gaaatttcaa aaaaatttgg ggcagaacgt gaaaaggcct
    19381 tgaatgacgc tcttaaattg attgagaaag actttggtaa aggatcaatc atgcgtttgg
    19441 gtgaacgtgc ggagcaaaag gtgcaagtga tgagctcagg ttctttagct cttgacattg
    19501 cccttggctc aggtggttat cctaagggac gtatcatcga aatctatggc ccagagtcat
    19561 ctggtaagac aacggttgcc cttcatgcag ttgcacaagc gcaaaaagaa ggtgggattg
    19621 ctgcctttat cgatgcggaa catgcccttg atccagctta tgctgcggcc cttggtgtca
    19681 atattgacga attgctcttg tctcaaccag actcaggaga gcaaggtctt gagattgcgg
    19741 gaaaattgat tgactcaggt gcagttgatc ttgtcgtagt cgactcagtt gctgcccttg
    19801 ttcctcgtgc ggaaattgat ggagatatcg gagatagcca tgttggtttg caggctcgta
    19861 tgatgagcca ggccatgcgt aaacttggcg cctctatcaa taaaaccaaa acaattgcca
    19921 tttttatcaa ccaattgcgt gaaaaagttg gagtgatgtt tggaaatcca gaaacaacac
    19981 cgggcggacg tgctttgaaa ttctatgctt cagtccgctt ggatgttcgt ggtaatacac
    20041 aaattaaggg aactggtgat caaaaagaaa ccaatgtcgg taaagaaact aagattaagg
    20101 ttgtaaaaaa taaggtagct ccaccgttta aggaagccgt agttgaaatt atgtacggag
    20161 aaggaatttc taagactggt gagcttttga agattgcaag cgatttggat attatcaaaa
    20221 aagcaggggc ttggtattct tacaaagatg aaaaaattgg gcaaggttct gagaatgcta
    20281 agaaatactt ggcagagcac ccagaaatct ttgatgaaat tgataagcaa gtccgttcta
    20341 aatttggctt gattgatgga gaagaagttt cagaacaaga tactgaaaac aaaaaagatg
    20401 agccaaagaa agaagaagca gtgaatgaag aagttccgct tgacttaggc gatgaacttg
    20461 aaatcgaaat tgaagaataa gctgttaaag cagtggagaa atccgctact ttttcgattt
    20521 ttgattcaag tttttagatt atatatagta gcttgaaata agatatgaac aactttatta
    20581 ggaaagtcaa attaatttct agaaatgttt tagcagctac agcgtactat tccaaactca
    20641 accaactata atagatcgaa actagaatag tacacatcta cttctaaaac attgttaaaa
    20701 atcgatttga ctgtccttat ttcattccgc tatatataag tttgctgttt cttgtcgctc
    20761 ctctggaaag ctgatataat agctttatga ataaaaaacg aacagtggac ctgatacatg
    20821 gtccgattct tccctcgctc ttaagcttca cctttccaat cttgctatca aatatttttc
    20881 aacagctcta taacactgct gatgtcttga ttgttggacg atttcttggt caagaatcct
    20941 tggctgcagt aggagcgacg acagcgattt ttgacctgat tgtaggcttt acacttggtg
    21001 ttggcaatgg catggggatt gtcattgctc gttattatgg ggctcggaat ttcactaaaa
    21061 tcaaggaagc agtagcagcc acctggattt taggtgctct tttgagcatt ctagttatgt
    21121 tgctgggctt tcttggcttg tatcctctct tgcaatactt agatactcct gcagaaattc
    21181 ttcctcaatc ttatcaatat atttctatga ttgtgacctg tgtaggtgtc agctttgctt
    21241 ataatctttt tgcaggcttg ttgcggtcta ttggtgacag tctagcagcc ctgggatttc
    21301 tgattttctc tgccttggtt aatgtggttc tggatctcta ttttattacg caattgcatc
    21361 tgggagttca atccgcagga cttgctacca ttatttcgca aggtttatca gcggttctct
    21421 gcttttatta tattcgtaaa agtgtgccag aactcttgcc acagtttaaa catttcaaat
    21481 gggacaaaag cttgtacgcg gatctcttgg agcaaggttt ggctatgggc ttgatgagtt
    21541 caattgtatc tatcggcagt gtgattttac agttttctgt taatacattt ggtgcagtga
    21601 ttattagtgc ccagacggca gctcgacgca ttatgacctt tgcccttctt cctatgaccg
    21661 ctatttctgc atcaatgacg acctttgctt ctcagaatct aggagctaag cgacctgacc
    21721 gtattgttca aggtcttcga atcggcagtc gtttaagtat atcctgggca gtttttgttt
    21781 gtattttcct cttttttgcc agtccagctt tggtttcctt cttggctagt tcgacagatg
    21841 gttacttgat agaaaatgga agtctctatc tgcaaatcag ttcaaccttt tatcccattt
    21901 tgagcctctt gttgatttat cgcaattgct tgcagggctt ggggcaaaag atccttcctc
    21961 tagtttctag ctttattgaa ctaatcggaa aaatcgtttt tgtggttttg attattcctt
    22021 gggcaggata taagggtgtt atcctttgtg aacctcttat ctgggttgcc atgacagttc
    22081 aactgtactt ctcattattc cgtcatccct tgataaaaga aggcaaggca atcttggcaa
    22141 ccaaagtgca atcctagttg gatttactga ataaaatcca tttcctctag tgaaaatcga
    22201 aaaaacttgt gttctcgtct ttagtttggt gttgaaaata gtttaacaga cttttgactt
    22261 cttttatatg atataataaa gtatagtatt tatgaaaagg acatatagag actgtaaaaa
    22321 tatacttttg aaaagctttt tagtctgggg tgttattgta gatagaatgc agaccttgtc
    22381 agtcctattt acagtgtcaa aatagtgcgt tttgaagttc tatctacaag cctaatcgtg
    22441 actaagattg tcttctttgt aaggtagaaa taaaggagtt tctggttctg gattgtaaaa
    22501 aatgagttgt tttaattgat aaggagtaga atatggaaat taatgtgagt aaattaagaa
    22561 cagatttgcc tcaagtcggc gtgcaaccat ataggcaagt acacgcacac tcaactggga
    22621 atccgcattc aaccgtacag aatgaagcgg attatcactg gcggaaagac ccagaattag
    22681 gttttttctc gcacattgtt gggaacggtt gcatcatgca ggtaggacct gttgataatg
    22741 gtgcctggga cgttgggggc ggttggaatg ctgagaccta tgcagcggtt gaactgattg
    22801 aaagccattc aaccaaagaa gagttcatga tggactaccg cctttatatc gaactcttac
    22861 gcaatctagc agatgaagca ggtttgccga aaacgcttga tacagggagt ttagctggaa
    22921 ttaaaacgca cgagtattgc acgaataacc aaccaaacaa ccactcagac cacgttgacc
    22981 cttatccata t
//
