LOCUS       NZ_CMIW01000015        14951 bp    DNA     linear   CON 27-NOV-2024
DEFINITION  Streptococcus pneumoniae strain SMRU3003, whole genome shotgun
            sequence.
ACCESSION   NZ_CMIW01000015
VERSION     NZ_CMIW01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001092805.1-RS_2024_11_27
            Annotation Date                   :: 11/27/2024 00:58:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,159
            CDSs (total)                      :: 2,109
            Genes (coding)                    :: 1,938
            CDSs (with protein)               :: 1,938
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 171
            CDSs (without protein)            :: 171
            Pseudo Genes (ambiguous residues) :: 0 of 171
            Pseudo Genes (frameshifted)       :: 69 of 171
            Pseudo Genes (incomplete)         :: 100 of 171
            Pseudo Genes (internal stop)      :: 55 of 171
            Pseudo Genes (multiple problems)  :: 44 of 171
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:52:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 31890
            Orig. end                         :: 46841
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CMIW01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..14951
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..14951
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14951
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:13596](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..13596)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    4..18
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.11"
                     /tool="antismash"
     gene            complement(181..975)
                     /gene="ccrZ"
                     /locus_tag="AD046_RS09385"
                     /old_locus_tag="ERS022513_01840"
     CDS             complement(181..975)
                     /EC_number="2.7.1.15"
                     /EC_number="2.7.1.229"
                     /GO_function="GO:0004747 - ribokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /GO_process="GO:0051726 - regulation of cell cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ccrZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /locus_tag="AD046_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01840"
                     /product="cell cycle regulator CcrZ"
                     /protein_id="WP_000363002.1"
                     /sec_met_domain="APH (E-value: 1.3e-19, bitscore: 63.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGLA
                     REQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQLS
                     RLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDVRHS
                     NWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTVLSKL
                     YWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            complement(1136..1747)
                     /locus_tag="AD046_RS09390"
                     /old_locus_tag="ERS022513_01841"
     CDS             complement(1136..1747)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /locus_tag="AD046_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01841"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000394036.1"
                     /sec_met_domain="Abi (E-value: 5.2e-21, bitscore: 67.0,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALIIVSLL
                     VTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHLAE
                     VSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSNVPS
                     FIFYLLGGLLLGLAYKKSQNLWVSTLVHMFYNSWPLLYYL"
     gene            complement(1898..2131)
                     /gene="blpZ"
                     /locus_tag="AD046_RS09395"
                     /old_locus_tag="ERS022513_01842"
     CDS             complement(1898..2131)
                     /codon_start=1
                     /gene="blpZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /locus_tag="AD046_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01842"
                     /product="immunity protein BlpZ"
                     /protein_id="WP_000276498.1"
                     /transl_table=11
                     /translation="MYKHLFFLDSKTLDRLTPYILVLASDTIAFNVFVLTFVSAVVFNF
                     LNSMLALMAIFIGAGYVVGFWLLILNENQRAN"
     gene            complement(2173..2862)
                     /locus_tag="AD046_RS09400"
                     /old_locus_tag="ERS022513_01843"
     CDS             complement(2173..2862)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /locus_tag="AD046_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01843"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000760523.1"
                     /sec_met_domain="Abi (E-value: 2e-15, bitscore: 49.1,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNFVW
                     IQNILSLLFSGVMIWILVKTGHGYLFRIPRKKWLWYSILTVLVVVLHISFNVQTAKHVQ
                     STAEGWNVLIGYSGTNFAELGIYVTLFFLTPLMEELIYRGLLQHAFFKHSRFGLDLLLP
                     SILFALPHFLSLPSLLDIFVFATFGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLT
                     FLHRVLG"
     gene            complement(2914..3297)
                     /locus_tag="AD046_RS09405"
                     /old_locus_tag="ERS022513_01844"
     CDS             complement(2914..3297)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398494.1"
                     /locus_tag="AD046_RS09405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01844"
                     /product="hypothetical protein"
                     /protein_id="WP_016398494.1"
                     /transl_table=11
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGVF
                     LLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHIFI
                     VFNVLMYLLSSSQVSLKKNKLSS"
     gene            complement(3926..4258)
                     /locus_tag="AD046_RS09415"
                     /old_locus_tag="ERS022513_01846"
     CDS             complement(3926..4258)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826248.1"
                     /locus_tag="AD046_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01846"
                     /product="immunity protein"
                     /protein_id="WP_224757293.1"
                     /transl_table=11
                     /translation="MLVSTYLFLFSISISSVFQFLLVVINLTSILVTVYLTREMRLREF
                     EDDDLVSPRTNQLMFIGLTGFMSIICLYRGITAGESYQQLIAYIGAILCLIIMLLLIWG
                     LKYYKK"
     misc_feature    4629..4642
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.08"
                     /tool="antismash"
     gene            complement(4778..4897)
                     /locus_tag="AD046_RS09420"
     CDS             complement(4778..4897)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /locus_tag="AD046_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346296.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKIFSKSSKKDTDSTL"
     gene            complement(4900..>4965)
                     /locus_tag="AD046_RS13390"
                     /pseudo=""
     CDS             complement(4900..>4965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863320.1"
                     /locus_tag="AD046_RS13390"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ComC/BlpC family peptide pheromone/bacteriocin"
                     /pseudo=""
                     /transl_table=11
                     /translation="VTGAAGGAILGGVAYAATCWW"
     gene            complement(5001..5150)
                     /gene="blpO"
                     /locus_tag="AD046_RS09425"
     CDS             complement(5001..5150)
                     /codon_start=1
                     /gene="blpO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /locus_tag="AD046_RS09425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="WP_001809846.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-11,
                     bitscore: 37.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMSQFSVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDGC
                     ATTV"
     misc_feature    5158..5173
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            complement(5394..5642)
                     /gene="blpK"
                     /locus_tag="AD046_RS09430"
                     /old_locus_tag="ERS022513_01848"
     CDS             complement(5394..5642)
                     /codon_start=1
                     /gene="blpK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379965.1"
                     /locus_tag="AD046_RS09430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01848"
                     /product="bacteriocin-like peptide BlpK"
                     /protein_id="WP_000379965.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.6e-12,
                     bitscore: 39.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKMMSQFSVMDTEMLACVEGGGCNWGDFAKAGVGGAAVVAALG
                     CAAGGVKYGKILGPWGAAIGGIGGAVVCGYLAYTATS"
     gene            complement(5711..5980)
                     /gene="blpJ"
                     /locus_tag="AD046_RS09435"
                     /old_locus_tag="ERS022513_01849"
     CDS             complement(5711..5980)
                     /codon_start=1
                     /gene="blpJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093248.1"
                     /locus_tag="AD046_RS09435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01849"
                     /product="bacteriocin-like peptide BlpJ"
                     /protein_id="WP_001093248.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.2e-20,
                     bitscore: 63.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMLSQLEVMDTEMLAKVEGGYSSTDCQNALITGVTTGIITGG
                     TGAGLATLGVAGLAGAFVGAHIGAIGGGLTCLGGMVGDKLGLSW"
     gene            <6088..6567
                     /locus_tag="AD046_RS09440"
                     /old_locus_tag="ERS022513_01850"
                     /pseudo=""
     CDS             <6088..6567
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /locus_tag="AD046_RS09440"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01850"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="HEYKAIKRYWKLIQQDSRKLSDKRFYRPTFRMHLTNKEILNKLLS
                     YSEDLKHHYQLYQLLLFHFQNKEPEKFFGLIEDNLKQVHPIFQTVFKTFLKNKEKIVNA
                     LQLPYSNAKLEATNNLIKLIKRNAFGFRNFENFKKRIFIALNIKKERTKFVLSQA"
     gene            complement(6681..7172)
                     /locus_tag="AD046_RS09445"
                     /old_locus_tag="ERS022513_01851"
     CDS             complement(6681..7172)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671992.1"
                     /locus_tag="AD046_RS09445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01851"
                     /product="hypothetical protein"
                     /protein_id="WP_000671990.1"
                     /transl_table=11
                     /translation="MKFQTNNSLYKLMNLIIYLFLLYLFIDLLMKSGILDEQIDKLSEL
                     SNLFTIKIETILTVISVVFTFIATLIEYGFSLFLITLFFDKNKRNFGDILLSKNITLSF
                     SILLCYLFNPSDIKFAYFSVLTVLLIGITNYARFKNLRLTVVFSVPFLFNAIMSIINSF
                     "
     gene            complement(7153..7749)
                     /locus_tag="AD046_RS09450"
                     /old_locus_tag="ERS022513_01852"
     CDS             complement(7153..7749)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000687786.1"
                     /locus_tag="AD046_RS09450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01852"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_000687787.1"
                     /transl_table=11
                     /translation="MKIENESKSYDKCILKNISLEIDKGIYRVEGENGSGKSTLLQLLA
                     GLETFDSGLKNCVSKDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINTFF
                     DNKIGDNYMTASTGTKFKLGLSLIFAKNWDYIFIDETLSTVDARSIDMIAKRLISMKES
                     STIIYVSHNLLNQELISKSQRILIEEGRVYEISNK"
     gene            complement(7746..8228)
                     /locus_tag="AD046_RS11870"
                     /old_locus_tag="ERS022513_01853"
     CDS             complement(7746..8228)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232094.1"
                     /locus_tag="AD046_RS11870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01853"
                     /product="stage II sporulation protein M"
                     /protein_id="WP_001232094.1"
                     /transl_table=11
                     /translation="MRKSGFLIYYVLFCIVCFLLGLLLSFILKNETFATIPPKLELQFT
                     LTVLQANSTNFLLYLFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHALIE
                     IPNFIWYQGMSQYLLYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEGIKL"
     gene            complement(8225..9361)
                     /locus_tag="AD046_RS09460"
                     /old_locus_tag="ERS022513_01854"
     CDS             complement(8225..9361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698829.1"
                     /locus_tag="AD046_RS09460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01854"
                     /product="hypothetical protein"
                     /protein_id="WP_000698828.1"
                     /transl_table=11
                     /translation="MKILSKKECESILGYLNFIGITLLFFVIISLSIYFKSYLPFQGKL
                     FLLFLVVDYATLNRYNMKLPIQSKKINTFYIRKNYIFLYLLAIVKKYYSFQILQSFIYL
                     FILYFLDIIGYFYLSITLCLIAIQIISLILPSLFSIISKLFLFLSIGLLSIEQGQVVIY
                     VILLNYFILVMGILDNHASNFYFKSSRMSQKRFRSSLFILLRFCWLNKGLTFSFILISI
                     LLSYLFWYMMTMLSIDDTKIPILFLYTSIYITLMEAIIGNHKSSIGVDLALLQLSALNH
                     SKMNFFFKNAQLMMLTHLISFLQFSLLLCLIPVTSYSNDIKSILLNLLLIPFNYFIAYV
                     YYKKALFLIKGTVSLLRWSFLVLYCFLIIFVILVGGIR"
     gene            complement(9368..9664)
                     /locus_tag="AD046_RS09465"
                     /old_locus_tag="ERS022513_01855"
     CDS             complement(9368..9664)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837727.1"
                     /locus_tag="AD046_RS09465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01855"
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="WP_000837726.1"
                     /sec_met_domain="Bacteriocin_IId (E-value: 2e-22, bitscore:
                     71.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTKA
                     AATVVNLISAYSTVTAVISIVGAITGVGSIGSGIAATVLYILKKKGAAKAALW"
     misc_feature    complement(10144..10155)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.13"
                     /tool="antismash"
     gene            complement(10207..11100)
                     /locus_tag="AD046_RS09470"
                     /old_locus_tag="ERS022513_01856"
     CDS             complement(10207..11100)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343891.1"
                     /locus_tag="AD046_RS09470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01856"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_000343888.1"
                     /transl_table=11
                     /translation="MDELKREIGYKIKTIRRSCGKTQIDICGDESELTIRQLARIENGQ
                     ALATLPKLLLIADKLGVSLQNIVDVKVIEIPKGFLKLKDELIHSQTYADKGRIERKEAI
                     LEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVND
                     LLIIELYFFCCAMGLEDKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQTEDS
                     LIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQV
                     LVQRILAEKQIDFPTT"
     gene            complement(11121..11315)
                     /locus_tag="AD046_RS13040"
     CDS             complement(11121..11315)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757183.1"
                     /locus_tag="AD046_RS13040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000756776.1"
                     /transl_table=11
                     /translation="MKKVLKYFLVFVFLFLMNIFIFKILATLGFQLIMSEKSYIVLPLF
                     SLIVLYMIDKRIRKKKKSL"
     gene            complement(11724..11849)
                     /locus_tag="AD046_RS13185"
                     /old_locus_tag="ERS022513_01857"
     CDS             complement(11724..11849)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="AD046_RS13185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01857"
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            complement(11852..>11917)
                     /locus_tag="AD046_RS13395"
                     /pseudo=""
     CDS             complement(11852..>11917)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863320.1"
                     /locus_tag="AD046_RS13395"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ComC/BlpC family peptide pheromone/bacteriocin"
                     /pseudo=""
                     /transl_table=11
                     /translation="VTGAAGGAILGGVAYAATCWW"
     gene            complement(11953..12102)
                     /gene="blpO"
                     /locus_tag="AD046_RS09485"
     CDS             complement(11953..12102)
                     /codon_start=1
                     /gene="blpO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /locus_tag="AD046_RS09485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="WP_001809846.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-11,
                     bitscore: 37.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMSQFSVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDGC
                     ATTV"
     misc_feature    12110..12125
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            complement(12346..12594)
                     /gene="blpK"
                     /locus_tag="AD046_RS09490"
                     /old_locus_tag="ERS022513_01858"
     CDS             complement(12346..12594)
                     /codon_start=1
                     /gene="blpK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379965.1"
                     /locus_tag="AD046_RS09490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01858"
                     /product="bacteriocin-like peptide BlpK"
                     /protein_id="WP_000379965.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.6e-12,
                     bitscore: 39.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKMMSQFSVMDTEMLACVEGGGCNWGDFAKAGVGGAAVVAALG
                     CAAGGVKYGKILGPWGAAIGGIGGAVVCGYLAYTATS"
     gene            complement(12663..12932)
                     /gene="blpJ"
                     /locus_tag="AD046_RS09495"
                     /old_locus_tag="ERS022513_01859"
     CDS             complement(12663..12932)
                     /codon_start=1
                     /gene="blpJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093248.1"
                     /locus_tag="AD046_RS09495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01859"
                     /product="bacteriocin-like peptide BlpJ"
                     /protein_id="WP_001093248.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.2e-20,
                     bitscore: 63.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMLSQLEVMDTEMLAKVEGGYSSTDCQNALITGVTTGIITGG
                     TGAGLATLGVAGLAGAFVGAHIGAIGGGLTCLGGMVGDKLGLSW"
     gene            complement(13399..13596)
                     /gene="blpI"
                     /locus_tag="AD046_RS09500"
                     /old_locus_tag="ERS022513_01860"
     CDS             complement(13399..13596)
                     /codon_start=1
                     /gene="blpI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093259.1"
                     /locus_tag="AD046_RS09500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01860"
                     /product="bacteriocin-like peptide BlpI"
                     /protein_id="WP_001093259.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 8.9e-12,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMEQFSVMDNEELEIVSGGRGNLGSAIGGCIGAVLLAAATG
                     PITGGAATLICVGSGIMSSL"
     gene            13894..14481
                     /locus_tag="AD046_RS13325"
                     /old_locus_tag="ERS022513_01861"
     CDS             13894..14481
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855030.1"
                     /locus_tag="AD046_RS13325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01861"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_000205166.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.7e-43, bitscore:
                     138.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTN
                     KEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQTK
                     KDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPSSDF
                     QTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG"
     gene            14426..14887
                     /locus_tag="AD046_RS13330"
                     /old_locus_tag="ERS022513_01862"
     CDS             14426..14887
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="AD046_RS13330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01862"
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /protein_id="WP_309543754.1"
                     /transl_table=11
                     /translation="MVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQV
                     MSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALA
                     STILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMFIIFSFMKPF"
ORIGIN
        1 cagggttttg cttggccata cctgaaacaa aggcaccctt tccacttcca acttccacat
       61 gaatgggatt atcattgcca aacaagtccc gccattttgc cttggcttcc aagggattga
      121 ggaccacata ctggggattt gcctctagta attctgttgc ccctttacga tttctaactc
      181 tcatcttctc tttccatact tgtctcggaa atgacgcaaa ccatgaatct cccgattgac
      241 attttctaaa tcttggttca tataatactt ggaaatctga ctcaaataag acaattgacc
      301 ataccaatac aatttactta ataccgtttg attgtacttg taaccgtagt aggtcaacca
      361 ttccttccac tgatgttctg aaatataatg gcagagcata tgggccacat caaacatgcg
      421 atcggtcaag cgaaccgaat cccaatctac taaataaatc aagccactat ctgtctcaat
      481 ccaattacta tgtcgtacat ctccatggac aatggtcgca tggtcctctc taaatcctgg
      541 aatagtctga cgtaaatcag ccatcacttc actgataaaa tgatttttac gcaaagcatc
      601 tggagccgtt tcctgccaag actgtagtaa atctacaggt gtttccatgg catagcccaa
      661 acgactcaat tgtgtcatca acggacgtga gcgatgaaga cgggttaaaa tattgacgat
      721 ttgcttacga ttcatatcat agggggtcaa tatcttgcct gtcaaccatt cttgagcaca
      781 catatcacgc ccatctgcca aacgacgact ccataataat tgtggagcaa tttgttctct
      841 agctagacca ggtaggattg gagaggtgtt catttttaca aagatgcgct tcccatcagg
      901 atagctaccc atataagcct tgccactttt cccaggtatg ggagtcagtg ttagctcatt
      961 atcacccaaa tccatttctt tcctccgtat aaagtttcct tactattcta ctagtttttg
     1021 gcctattcgt caaccactct aacccgattc tcaaagaaaa gcctctggat tggcttgggt
     1081 atcattatag cttgaaaaag gtaagcaccg tcttctgctt accttttcat aatttttata
     1141 aataatatag gagtggccaa ctgttgtaaa acatgtggac tagagtagaa acccataggt
     1201 tttggctctt tttataagca aggcccagca acaagccccc aagtagataa aaaataaacg
     1261 aagggacatt agaaggtcca tgcatgaaag aaaagagaga ggaagttagc acaagcccta
     1321 accaagaatt gtcaaaaacc gcaccttgaa gaagtcctct gaaaatgagt tcctcctgga
     1381 tggggccaaa aactgaggta gtcaaaatca aagacaggga aattcctctg ctgacttccg
     1441 ccaagtgttg gacccctgag ccagaagaaa cagcgaagaa atgaatataa accagcgtct
     1501 caagtacact tagaagaaag attgcaatga aaagcaaaag ttgtttcttg cttaacatcc
     1561 caaaagaaat catttcaaac tttctagcat aagcaacact cagcgaggtt acaagaagac
     1621 ttacaataat caatgcagat tcattttgaa aaaaatcccc atggttaatc gtataaggaa
     1681 ctgtaatgac aattattagt actaaaaatc caaaacacaa ggcatgaaat ttatcaaaaa
     1741 actccataaa attatcctcc tcaacaaaca gacttcctac acgtcattct ttagttctag
     1801 cctttccaaa acaaaccatt ttatactctt cgaaaatcaa attcaaacca cgtcaacgtc
     1861 gccttgccgt actcaagtac agcctgcggc tagttcccta gtttgctctt tgattttcat
     1921 tgagtattag taaccaaaat ccgaccacat agccagcccc tatgaatata gccattaaag
     1981 ctagcatgga atttaggaaa ttaaaaacca ccgcagatac aaaggttagc acaaaaacat
     2041 taaaagcaat ggtgtcagaa gccaagacta gaatataggg tgtcaaccga tctaaagttt
     2101 tggaatctag gaaaaataag tgtttataca tgatgacctc ctctatggct gaaaagcaag
     2161 ccttttgttt ttttacccca agaccctatg tagaaaagtg agcaaaaacg ggaaggtcgc
     2221 tacaatatta ttgatcacat gcaccgcata ggatggataa atactcttgg tatagcgggt
     2281 caaaccggca aagatgattc caaatgttgc aaagacgaag atatctaaca gactaggcag
     2341 actcaaaaaa tgaggaagag caaacaaaat ggaaggaaga agcaaatcaa ggccaaatcg
     2401 cgaatgctta aagaaggcgt gttgaagtaa tcccctataa atcaactctt ccattagtgg
     2461 agtcaggaaa aacagggtta catagatacc tagctcagca aagttggtcc cactataacc
     2521 aatcaatacg ttccaaccct cagcagttga ctgaacatgt ttagctgtct gaacgttaaa
     2581 agagatatgg agcactacca ctaatactgt caaaatagaa taccaaagcc atttttttct
     2641 tggaatgcga aagagatagc catggcctgt cttaaccaga atccaaatca tgactccgct
     2701 aaatagtaaa ctcaagatat tttgaatcca gacgaaattg ccaatctggg aagaaaattg
     2761 ccaataattt tggacgataa gcgtcagctg agaaagacca aatacgaaaa ataagtaaga
     2821 gaagactgca cttattttga atagaagttg atactttttc atagaaattc ttcctactat
     2881 gacctcacct tgtcaggctc tactgctgta agattaagaa gacagtttgt tctttttaag
     2941 gctaacctga ctactagata atagatacat taagacatta aagacaatga aaatatgtcc
     3001 atagaataaa atcaacctcg catccaaacc aagataaagt ttgattatca aaaagatgag
     3061 caaaagaatt tgaaaccata aggtttttcc aaaaataaat ttgaatcgat ttcgaatatc
     3121 tacttccttg atttttaccg ccaccccttt attagcaaga aggaaaactc ctgcttcaaa
     3181 caaaccactg taaagaacaa gccacccaat agatacgata gagatttgta aaaatgtccc
     3241 taaaagaata tccaacacac tactcaagaa aataacaaaa aataatctgt atttcatatt
     3301 aaatacctcc attcatttat ttcactaaca atttaataga gccttctact caaatatcct
     3361 gtcagaaaag gatagaaagc tactttttat aatacttcaa gccccacatg agcagaagcg
     3421 tgataaacaa gcagagaata cacctatata aacgattagt tgttgataga attctgtttc
     3481 tgaaatacct ctatacaaac aaatgacaaa cataaaatct gccaagccga taaacataag
     3541 ttgattggtt ctaggactaa ccaaatcatc atttacttat atttaagagt atctctttta
     3601 tgttagtgta tgttaacact aaaaaacaag ttaggccaat aatatttaaa atgaacaata
     3661 acggggttaa gtctctaaaa aaattatcta ctgacactac aagaaatact atacatatta
     3721 tagtcgaaac tatctttttc ttatccataa ttatttactc ctttcctaac aaatccaact
     3781 tatcaatcaa gagcgatttt taacataatg tagcagcacc cgttgcaact ttgacaagtt
     3841 tagtatatca ttgtttttta aaatttttca tccaaatctt gaattgtcat cgaaacctcc
     3901 taaattgcaa aaacttcatt agcccctact ttttataata cttcaaaccc caaatgagta
     3961 gaagcatgat gatcaagcaa agaatagcac caatataagc gattagttgt tgataagatt
     4021 ctcctgctgt gatccctcta tacaaacaaa taatagacat aaagcctgtc aagccgataa
     4081 acatgagttg attggttcta ggactaacca aatcatcatc ttcaaactct cttaatctca
     4141 tttccctagt aagataaaca gtaaccaaaa tagaagtcaa gttaataact actaaaagaa
     4201 attggaaaac tgacgaaata gaaatagaaa atagaaatag ataagtagaa acaagcaaag
     4261 gcaactgacc caggaacaat ctcacaaaga atatgattct ttttaatcaa gaaaatcttt
     4321 catttctttt ctttcttttt aattaaagaa aaatagatca taaccgcaat catataggct
     4381 atggtataaa atagattata ccaaatactc tccctaagcg gataaagaaa gatggacatg
     4441 atcagataca gaacgaaaat aatcagtatt tttttcttca taagttttcc tcctaaatgt
     4501 gcgatttatc ttagttgagc aagaacattt acactgctag tatagcactt attttgacct
     4561 tggatcactc aaatcataaa tggtcatcaa aacctcttga attgtaaaaa ttaaaaaagc
     4621 aagcatgaaa aacatacttt cctctttata ttgtattgat accaacttgt ttgtagactt
     4681 ttcatcctgc tatcacatat cattttgaca ggcgaaacaa tattaaagaa actcccctgt
     4741 aaattaagct agcaaataca ggggagaaat ttatttttta gagagtacta tccgtatcct
     4801 ttttggaaga ttttgaaaat atttttctaa ttaagtcatc catataagga ccaaatatac
     4861 caactactaa accaataata aaacttttaa aatccataat taccaccaac atgttgctgc
     4921 ataggctaca cctccaagta tagctccacc tgcagcacca gttacaccta ttcctatagc
     4981 aaatggtccc aatagaaatg tcaaaccgtt gttgcacacc catcaattgc gccatatgca
     5041 acccctgctg cacaactaat ttttcttccc caatcaatat ctccaccttc aacgcaagca
     5101 agcatttcat tatccataac agaaaattgt gacatcattt ttgtattcat atagtatgtc
     5161 acttttcagt tacggaacaa gtttaatata aaaattatca aaaaaacata ggcaataaag
     5221 agaaaaatta atttatcata gattagaaat aatatgacaa aacaattcaa tgatgttaat
     5281 tcaatagtct tttgtttttt atcagagata cttatggata gataaataag ataggtttga
     5341 aaagcgaaga gaataataaa gaatatagcc ttcataaaat ttagctttca tttttatgat
     5401 gtagcggtat aggctaaata tccacaaacc actgctcctc caattcctcc tattgcagcg
     5461 ccccatggtc ctagaatttt cccatatttc actccacccg ctgcacaacc taaagcagca
     5521 actacagctg ctcctccaac acctgctttg gcaaaatctc cccaattgca tccgccacct
     5581 tcaacgcaag caagcatttc agtatccata acagaaaatt gtgacatcat ttttgtatcc
     5641 atgacaaata ctcctttttt aaaaaactaa aataaatcag aatagaatcc tcataatttt
     5701 actataagtc ttaccaactt agtcccaatt tatcaccaac catacctcct aagcatgtta
     5761 atccaccccc aattgcacca atgtgtgctc caacaaatgc accagcaagt ccagctactc
     5821 ctaaagtggc caaacctgct ccagttccac cagttataat tcccgtagtg actcctgtaa
     5881 tcagtgcatt ttgacaatca gtggagctat accccccttc aactttcgca agcatttcag
     5941 tatccataac ctctaactgt gacaacattt ttgtattcat gagactttcg atgaaactga
     6001 ttcatgattt ggacatgcac acgactcata gcacggctaa gatgnaagac tttggtaaca
     6061 aattgaaaat aaaaaggagg tattcatcat gaatacaagg ctatcaagcg ctactggaag
     6121 ctcatacaac aggatagtcg taaactgagt gataagcgat tttatcgtcc tacttttcgt
     6181 atgcacttaa ccaataaaga gattttaaac aagcttttga gttattcgga agacttgaaa
     6241 caccactatc agctctatca actcttgctg tttcactttc agaataagga accggagaaa
     6301 tttttcggac ttattgagga caatcttaag caggttcatc ctatttttca gactgtcttt
     6361 aaaacctttc taaagaacaa agagaaaatc gtcaacgccc ttcaactacc ctattcaaac
     6421 gccaaattgg aagcgaccaa taatctcatc aaacttatca aacgcaatgc ctttggtttt
     6481 cgaaactttg aaaacttcaa aaaacggatt tttatcgctc tgaacatcaa aaaagaaagg
     6541 acgaaatttg tcctttctca agcttagctt ttcttcaacc cactacagtt gacaaagagc
     6601 cgaaaatata agaattacaa gttaacaaaa ccgaaatgat ttcatatcat tattaagtaa
     6661 agaaaaaaat tttagtattt ctaaaaacta tttataatag acattatagc attaaataaa
     6721 aatggtacag aaaacactac tgtcaatctt aaatttttaa atctcgcata atttgttatc
     6781 ccaattagta atactgtcaa tacgctgaaa taggcaaact ttatatccga tggattaaat
     6841 aaataacaaa gtaaaatgct aaaacttaag gttatatttt tagataaaag aatatctcca
     6901 aagttcctct tattcttatc aaaaaataat gtaatcagaa agagagaaaa tccatattca
     6961 ataagagttg ctataaatgt gaaaacaaca gaaatcactg tcaatattgt ttctatttta
     7021 attgtaaaaa gattagatag ttcagataat ttatcaattt gttcatctaa aattcccgac
     7081 ttcatcagta aatcaataaa caaatataaa agaaaaagat aaataatcag attcattaat
     7141 ttgtataaac tattatttgt ttgaaatttc ataaacccgt ccttcctcta ttaaaatcct
     7201 ttgagatttg ctaatcaatt cttgattcaa taaattatga gatacatata taatagtaga
     7261 gctttctttc atggaaatta agcgtttagc aatcatatca atacttcttg catccactgt
     7321 tgataaagtc tcatcaataa aaatataatc ccaattttta gcaaaaatta aggataagcc
     7381 taatttgaat tttgttccag tagatgctgt catatagtta tctccgattt tattatcaaa
     7441 aaaagtatta atttgttctt tatcctcaaa tgatagatgg atttgaaaag aatcacacaa
     7501 caactgcaaa ttttcttcta tagtaaatgg aacaacccca agctgattgg tatcaaggta
     7561 tagtacatct ttggagacac aattctttaa accactatca aaagtctcta gcccagctaa
     7621 aagttgtaga agggtgctct ttcctgaacc attctctcct tcaactctgt aaattccctt
     7681 atcaatctct agtgatatat ttttcaatat acatttatca taacttttag attcattttc
     7741 aattttcata atttaattcc ctctatcaac gctgctaaaa ttaataaaag ataagaaatg
     7801 atataccatt ttaaattact ttttatataa ataagtatat ttttaattcc cctatccttc
     7861 aataatcggt ataaaagata ctgactcata ccttgatacc aaataaaatt cggtatttca
     7921 ataagagcat gaggtaatat tccttttatt gtagctacta ttccaatcat ctgaccagat
     7981 atacccaatt gtattcctaa agatagcaaa tcaaaaagtt gcaataaggg cgaaatcgga
     8041 aaacagaata gatatagcaa aaaatttgta gaatttgcct gtaaaactgt caatgtaaat
     8101 tgtaattcca gtttcggagg tatagtagca aaagtctcat tttttaatat aaagcttaaa
     8161 agtaaaccta gtaaaaaaca gactatacaa aataacacat agtaaatcag aaaaccactt
     8221 tttctcatct aatgccccct actaaaatta caaatattat cagaaaacaa tataaaacca
     8281 gaaaactcca tctcaataaa ctaactgtac ctttaattaa aaatagagct ttcttataat
     8341 agacataggc tataaaataa ttgaatggaa tcaataacaa attcaacaaa atacttttta
     8401 tatcattact ataacttgtc accggaatca aacataacaa caatgaaaat tgtaagaaag
     8461 agattaaatg cgtcaacatc attagttgtg cattcttaaa aaagaaattc attttagaat
     8521 gattaagagc agataattga agtaaagcta gatctacccc aattgaggat ttatgattcc
     8581 ctattattgc ctccattaat gtaatatata ttgaggtata aagaaataat attggtattt
     8641 ttgtgtcatc aattgataac atcgtcatca tataccaaaa tagataggaa agaagaatac
     8701 taatcaaaat aaaagaaaaa gttaaccctt tatttaacca acaaaaacga agcaatataa
     8761 atagactgct acgaaatctt ttttgactca ttcgactgct tttaaaatag aaattactcg
     8821 catgattatc taatatcccc atgactaaaa taaaataatt gagtagtatg acataaatta
     8881 caacttgtcc ttgttctata gacaatagtc ctatagataa aaataagaac aatttactta
     8941 taattgaaaa caaactaggt agaattaaag aaataatttg aatagctatc aaacaaagag
     9001 taatggataa ataaaaatat ccaataatat ctagaaaata caaaataaat aaataaatga
     9061 atgattgtaa aatttggaaa gaataatatt tcttgacaat ggcaagaaga tagagaaaaa
     9121 tatagttttt ccttatatag aaagtattta tttttttact ttggataggc agtttcatat
     9181 tataacgatt caaagtagcg taatctacta ccaaaaaaag taaaaataat ttcccttgaa
     9241 aaggaagata gcttttaaaa tagattgaca aacttatgat aacaaaaaac aaaagggtta
     9301 tcccaataaa attaagataa cctaaaatac tttcacattc ttttttagaa agtattttca
     9361 tctagttcta ccatagagct gctttagcag cacctttctt tttcaatata taaagaactg
     9421 ttgctgcaat acccgaacca atagaaccta ctcctgtgat tgcacctaca attgaaatta
     9481 ctgctgtaac tgtactataa gcactaatca aattgactac agtagcagca gcttttgtcg
     9541 aaattcctaa tgtcccagcc aacataggaa aagaaacaac acctaagctt aaccaactaa
     9601 tgactgctaa cattgctgaa acaataagaa atttattatg aaattccatt cttttagatt
     9661 tcattttagt gtactccttt tgtatattat gtatgtttta ttgagagtta attcgcacat
     9721 gttgtattcc taactctctt caaatgttcg tctatatttt atactacttt tattaacata
     9781 tctataataa ataaattact actacatttt cctagattat caaattactt ttatatcact
     9841 aagactcaat aaaagataat gtctatttaa cttttatacg attactacct cctttttagt
     9901 ttacacttcc tacatcataa ataaacatac tcaaccctca caatctccaa ataactcttc
     9961 tatatcattg aaaattgagt ttcatcctct atactaatgt aggaaaccta ttaaaacatt
    10021 cctttaatcc aatataagaa taccttgttc cattaatctc tacccgatat tatagataga
    10081 accaaattcc tatacttaaa aggacaaata acgttccacc cataataaac ctcctttctt
    10141 tttgagaacg ttttctttat aggtttagta tagcaaaaac atgaaaaaaa caacatgact
    10201 tagaagtcag gttgttggga aatctatctg tttttctgct aaaattctct gaactaatac
    10261 ctgatcgtct agcaattctg ctagagaaat cgccttttca tagaaacttt ctgcctctaa
    10321 aatattcttg tctacaaata aagcatattt tgcctttagc aaaaatagat gaggtcggta
    10381 aaaaacatgt cttgttttag caataatttt ctcaaatgtt tgaatatata tcagactatc
    10441 ttctgtctga atttggataa ataggctcag aagaactttt tccatttgaa ctaggctagc
    10501 cttatcttca tattctgaac atagcaatac tttttgagct aactcctcaa aatgttcttt
    10561 atcttctaat cccatagcac aacaaaagaa atacaattca ataatcaaca aatcatttac
    10621 agaaaaatat ttctttttta ataactgctg gaaatattct tccactaacc ctaaaccgta
    10681 ggtcacatct gaactaccat aaatatcaaa acgagcttgt gtcacatcca caattaactg
    10741 ctcttcctca ggcaaattct cataatagtt ttcatatatt tcctcaagta tagcttcttt
    10801 tcgttcgatt cttcccttat cagcgtaggt ttgagaatga atcagctcat ctttgagttt
    10861 taggaatcct tttggaatct ctataacctt aacatccaca atattctgta atgatactcc
    10921 aagtttatcc gcaatcaata ataatttagg aagtgttgct aaagcttgcc cattttcaat
    10981 acgtgctagc tgacgaatcg tcaactctga ttcatcacca caaatatcta tctgagtttt
    11041 tccacaagat cgcctaatag ttttgatttt ataaccaatt tcacgtttca actcatccat
    11101 agtaatactc cttaagttga ttacaaagat ttctttttct tcctaattct tttgtcaatc
    11161 atatataaaa cgataagcga aaacagcggt agaacaatat aactcttttc actcattatc
    11221 agctgaaatc ccagggttgc tagtatctta aagatgaaaa tattcatcaa aaatagaaaa
    11281 acaaatacta aaaaatattt taaaaccttc ttcatttctt ttcttcaact ttcctaattt
    11341 ctacacctat tttatcgaaa atatatataa aactccaaat aaacacttcg actgcacttt
    11401 ttttggcaaa aaatagacag aacaagagtc ctgcccacta aaaatatgct attgaaagga
    11461 aaatgatttt ttactgacac cctaggcaag cttggaacaa ataaatcatt gatagcaaca
    11521 tttgtgacat cctatttatt acttcaattt ctaatgtccc tgctatttct aagccgcctc
    11581 tggtatgatc tattcctagt cagaatagat aacaccgttc taaattacga ttcatagtta
    11641 ctcctttttt gactcgttac tataagactc ctctttacat gcgcaaaata attttgattc
    11701 agattcatca tttatagttt tgattatttt ttaacagatt tttctgtttt cttctccgaa
    11761 gactttaaaa atttttttct aattaaatca tccatataag gaccaaatat accaactact
    11821 aaaccaataa taaaactttt aaaatccata attaccacca acatgttgct gcataggcta
    11881 cacctccaag tatagctcca cctgcagcac cagttacacc tattcctata gcaaatggtc
    11941 ccaatagaaa tgtcaaaccg ttgttgcaca cccatcaatt gcgccatatg caacccctgc
    12001 tgcacaacta atttttcttc cccaatcaat atctccacct tcaacgcaag caagcatttc
    12061 attatccata acagaaaatt gtgacatcat ttttgtattc atatagtatg tcacttttca
    12121 gttacggaac aagtttaata taaaaattat caaaaaaaca taggcaataa agagaaaaat
    12181 taatttatca tagattagaa ataatatgac aaaacaattc aatgatgtta attcaatagt
    12241 cttttgtttt ttatcagaga tacttatgga tagataaata agataggttt gaaaagcgaa
    12301 gagaataata aagaatatag ccttcataaa atttagcttt catttttatg atgtagcggt
    12361 ataggctaaa tatccacaaa ccactgctcc tccaattcct cctattgcag cgccccatgg
    12421 tcctagaatt ttcccatatt tcactccacc cgctgcacaa cctaaagcag caactacagc
    12481 tgctcctcca acacctgctt tggcaaaatc tccccaattg catccgccac cttcaacgca
    12541 agcaagcatt tcagtatcca taacagaaaa ttgtgacatc atttttgtat ccatgacaaa
    12601 tactcctttt ttaaaaaact aaaataaatc agaatagaat cctcataatt ttactataag
    12661 tcttaccaac ttagtcccaa tttatcacca accatacctc ctaagcatgt taatccaccc
    12721 ccaattgcac caatgtgtgc tccaacaaat gcaccagcaa gtccagctac tcctaaagtg
    12781 gccaaacctg ctccagttcc accagttata attcccgtag tgactcctgt aatcagtgca
    12841 ttttgacaat cagtggagct atacccccct tcaactttcg caagcatttc agtatccata
    12901 acctctaact gtgacaacat ttttgtattc atgatgaata cctccttttt attttcaatt
    12961 tgttaccaaa gtcttaaatt caataaacaa atagattttt tatagtatct ttttgatttt
    13021 cttaaaaaag tatatacgtc tactatcttc ttaaaggtag cagtacctat tttttagtct
    13081 aagatttcaa taatcttgag tatctaaaat atcttaattt cgttattctc cttgcaataa
    13141 aaagttttac tatactattt attaacttgc agaaagcaaa aaatattagt aaataatagt
    13201 ttatagttaa gttttttatt cctaccaatc catcaactaa gtaaagcatc aacgattaca
    13261 taaacgattg ataatataat taaaattttg ctaactatct tattctcatc attcttagat
    13321 aactttgata ttttgtaagt aagtaaataa gacagtaaat taatagcgat aataatacta
    13381 tatttaagaa tcataatctt acaaagagga cataattcct gaacctacac aaataagtgt
    13441 tgctgctccc ccagttatcg gaccagtcgc agcagctaat agtactgctc caatacaacc
    13501 accgattgca gatcctaaat tgcctcttcc tccactaact atttcgagtt cttcattatc
    13561 cataacagaa aattgttcca tcatttttgt attcatgaca aatactcctt ttttcttttt
    13621 ttatttttgt cttgttgtaa ctttgataag tttagtatat catcgttttt taaaattttt
    13681 catccagatc ttgaattgtc atcgaaacgt cttgaattag cttttttatt tcaagccacc
    13741 tctatttcaa gccacctcta aatgtttaaa aaaaataatt tctaatcact tttttaccat
    13801 tcaggaagtt ttaatgacta ttcaagattt cataaaatat gaacttagtt ttatgacata
    13861 atagacctat ccactatatg aaaggaattg ccaatgactt cttataaacg tacatttgtt
    13921 cctcaaatag atgcgagaga ctgtggtgtc gctgccttag cctcgattgc taaattctat
    13981 ggttcagatt tttctctagc tcacttgaga gaacttgcaa agaccaataa agaagggacg
    14041 actgctcttg gcattgtaaa agccgctgat gaaatgggct ttgaaacaag acctgttcaa
    14101 gcagataaaa cgctctttga catgagtgat gtcccctatc catttatcgt tcacgttaac
    14161 aaagaaggaa aactccaaca ttactatgtt gtctatcaaa caaagaaaga ctatctgatt
    14221 attggtgatc ctgacccttc tgtaaaaatc actaaaatgt caaaagaacg ctttttctat
    14281 gaatggactg gagtagctat ttttctagct accaaaccca gctatcaacc ccataaagat
    14341 aaaaagaatg gtctactaag caagcttcct tcctctgatt ttcaaacaaa aatctctcat
    14401 tgcttacatt gttctctcaa gcttattggt cactattatc aatatcggtg gttcttatta
    14461 tctccaagga atcttggatg aatacatccc aaatcagatg aaatcaactt taggaatcat
    14521 ctcagttggt ctggttatca cctatatcct ccaacaagtc atgagctttt ccagagatta
    14581 tctcctaacc gttctgagcc agagattaag cattgatgtg attttatcct atattcgcca
    14641 tatttttgaa cttcccatgt ctttctttgc gacacgtcgt acaggagaaa tcatttcacg
    14701 gttcacagat gctaactcta ttatagatgc cttggcttct accattcttt ctctttttct
    14761 ggatgtttct attctgattc ttgtaggagg agtcttgctg gcacaaaacc ctaatctctt
    14821 cctcctttct cttctttcca ttcctatata catgttcatc atcttttctt ttatgaaacc
    14881 tttttgaaag ttctataatg aagttagcca ccttacctta gtcaagaatt agatgtttca
    14941 ctatgtttga g
//
