LOCUS       NZ_CMIW01000005         6253 bp    DNA     linear   CON 27-NOV-2024
DEFINITION  Streptococcus pneumoniae strain SMRU3003, whole genome shotgun
            sequence.
ACCESSION   NZ_CMIW01000005
VERSION     NZ_CMIW01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001092805.1-RS_2024_11_27
            Annotation Date                   :: 11/27/2024 00:58:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,159
            CDSs (total)                      :: 2,109
            Genes (coding)                    :: 1,938
            CDSs (with protein)               :: 1,938
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 171
            CDSs (without protein)            :: 171
            Pseudo Genes (ambiguous residues) :: 0 of 171
            Pseudo Genes (frameshifted)       :: 69 of 171
            Pseudo Genes (incomplete)         :: 100 of 171
            Pseudo Genes (internal stop)      :: 55 of 171
            Pseudo Genes (multiple problems)  :: 44 of 171
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:52:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 167234
            Orig. end                         :: 173487
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CMIW01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..6253
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..6253
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..6253
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:>6179](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..>6179)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(333..662)
                     /locus_tag="AD046_RS05180"
                     /old_locus_tag="ERS022513_01010"
     CDS             complement(333..662)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /locus_tag="AD046_RS05180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01010"
                     /product="hypothetical protein"
                     /protein_id="WP_000132583.1"
                     /transl_table=11
                     /translation="MTDTDPIKRAQTLITDLNKAYQACKQATADDVRFQEQLNSILGFL
                     AKAETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLILNE
                     NQRAN"
     misc_feature    801..814
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.71"
                     /tool="antismash"
     gene            939..1277
                     /locus_tag="AD046_RS05185"
                     /old_locus_tag="ERS022513_01011"
     CDS             939..1277
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /locus_tag="AD046_RS05185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01011"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_047499348.1"
                     /transl_table=11
                     /translation="MKHMIIQTQKTVYKVNVDDIYYIQTHPTKAHTVQIVTEEASFNML
                     QNLSNLENQCGETLMRCHRNCLVNLDKLKSIDFQERILFLGEEGQYAVKYARRRYREIR
                     QKWLKEGE"
     gene            1282..2019
                     /locus_tag="AD046_RS05190"
                     /old_locus_tag="ERS022513_01012"
     CDS             1282..2019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /locus_tag="AD046_RS05190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01012"
                     /product="response regulator transcription factor"
                     /protein_id="WP_050116081.1"
                     /transl_table=11
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLA
                     EVHEKGDHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFMPLSFRYQVS
                     ALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLET
                     SPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFP
                     NGGSCLIARYKVREVSEAINNLH"
     gene            2033..3373
                     /locus_tag="AD046_RS05195"
                     /old_locus_tag="ERS022513_01013"
     CDS             2033..3373
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099894.1"
                     /locus_tag="AD046_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01013"
                     /product="sensor histidine kinase"
                     /protein_id="WP_001017642.1"
                     /transl_table=11
                     /translation="MNIAWILLYTLVTNGLEIVIFFKVDGIDLTFERIFKAFLFKILLA
                     FVFVMISYIVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRGVS
                     YFVLPFLGQGQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRKEILDKAFQKSLT
                     QINWIMGGYYLVMESLSFFEYEQSIQSKTVRHLILVFYLLFFMGVIKKLDTYLKEKLYE
                     RLEQEQALRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIKEVYGS
                     VLKDSSQKLQNNKYDLGRLVNIRDKALKSLLAGKFLKARDKNIVFNVEVPEEIQVEGMS
                     LLDFLTIVSILCDNAIEASVEASQPHVSIAFLKNGAQETFIIENSIKEEGIDISEIFSF
                     GASSKGEERGVGLYTVMKIVESHPNTSLNTTCQNQVFRQVLTVIHTE"
     gene            complement(3444..3572)
                     /gene="blpC"
                     /locus_tag="AD046_RS05200"
                     /old_locus_tag="ERS022513_01014"
     CDS             complement(3444..3572)
                     /codon_start=1
                     /gene="blpC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358815.1"
                     /locus_tag="AD046_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01014"
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="WP_000358815.1"
                     /transl_table=11
                     /translation="MDKKQNLTSFQELTTTELNQITGGGLWEDLLYNINRYAHYIT"
     gene            complement(3629..4990)
                     /locus_tag="AD046_RS05205"
                     /old_locus_tag="ERS022513_01015"
     CDS             complement(3629..4990)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /locus_tag="AD046_RS05205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01015"
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="WP_050116083.1"
                     /transl_table=11
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKEI
                     TVTSQGEIAPTSVIASIQSTSDNPILANYLVANQVVEKGDLLIKYSETMEESQKTALAT
                     QLQRLEKQKEGLGILKQSLETTTDLFSGEDEFGYHNTFMNFTKQSHDIELGITKTNTEV
                     SNQANLSNSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTGNPHQSILNRYLVAS
                     QGQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVLRTQFL
                     QTASQQQLTVENQLTELKVQLDQATQRLENNTLTSPSKGIVHLNSEFEGKNRIPTGTEI
                     AQIFPVITDTREVLITYYVSSDYLPLLDKGQTVRLKLEKIGNHGTTIIGQLQTIDQTPT
                     RTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTTKKTYFDYFKDKILTHSD"
     gene            complement(5001..>6179)
                     /gene="blpA"
                     /locus_tag="AD046_RS05210"
                     /old_locus_tag="ERS022513_01016"
                     /pseudo=""
     CDS             complement(5001..>6179)
                     /codon_start=1
                     /gene="blpA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_125458604.1"
                     /locus_tag="AD046_RS05210"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_01016"
                     /product="peptide cleavage/export ABC transporter BlpA"
                     /pseudo=""
                     /sec_met_domain="TIGR01193 (E-value: 1e-180, bitscore:
                     596.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNI
                     DSEFVDYLEKSFKLSKYSILQTSLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNT
                     LFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDD
                     LSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQD
                     IKNIDKKVLRRHINYLPQQAYIFNGSILENLTLGGNHMISQEDILKACELAEIRQDIER
                     MPMGYQTQLSDGAGLSGGQKQRIALARALLTKAPVLILDEATSGLDVLTEKKVIDNLIS
                     LTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQSFYHHLFNK"
ORIGIN
        1 caggaggtag ttcgaggatt gaccagtttt gttttacttg tggaattagt tgttggcttg
       61 attaccttcc aagaaaaact agcccttcta gccttactag gagctggttt ggttttacta
      121 gtcttgtatt tgccttatca ggtaaaacgt cagatgcagg actaacattg ctgatacgac
      181 actaaaaaag aagttgagtt cagtctgtct caacttcttt tttgttacta caggataatg
      241 gttggtccgt agagacttat actcttcgaa aatctcttca aaccacgtca gcgtcgtctt
      301 accgtactca agtacagctt gcggctagct tcctagtttg ctctttgatt ttcattgagt
      361 attaacttgg tcttgacttg gtcaaagtgg aagcggtcat aggcccgcca agcggcgcga
      421 gttggagcat ctggatcaag agcgctgagt cccatgagaa gactggaagt ctggtaaaat
      481 ttttccaatt caatcaagaa tcgattatcc actgtttcag ccttggctag aaaaccaaga
      541 atagagttta attgctcctg aaagcggacg tcgtcagcgg ttgcctgttt gcatgcttga
      601 taggctttgt ttaagtcagt aatcaaagtc tgagctcttt tgatagggtc tgtatctgtc
      661 atgagaattc ctcctctaat ctgggtgcca gtcttgattc tagcaactgt gttttgatac
      721 tgtcagtcta tcacttttat ctcctttttc gcctttaaat ctttaattgt cattgaaatg
      781 tcttgaattg cgctgagtga attttatgat aaaatagttg taagctcatc atgatgttgt
      841 agaaaaataa tccttttagg agctttcaaa gactgtttag gattgggtgg gcttgggcta
      901 gaccttttct gttattcttt tcttaggagg agaatccaat gaaacatatg attattcaga
      961 cgcagaaaac agtctataaa gtaaacgtcg acgatatcta ctatatccaa acacatccaa
     1021 ctaaagccca taccgtacag attgttacag aagaagctag ttttaatatg cttcaaaatt
     1081 taagtaatct tgagaaccaa tgtggggaaa ccttgatgag atgtcatcga aattgtttgg
     1141 ttaatcttga taaattaaaa tcgattgatt ttcaagaaag aatccttttt ctcggagaag
     1201 aaggtcaata cgctgtcaag tatgccagac gtcgctatag agaaattcgt caaaaatggt
     1261 tgaaagaggg agagtaagaa gatgagaata tttgttttag aggatgattt ttcccaacag
     1321 actagaattg aaacgacgat tgagaaactt ttgaaagcac atcatatcat tcctagctct
     1381 tttgaggtat ttggcaagcc ggaccaactg ctggctgaag tgcatgagaa gggggaccat
     1441 cagctattct ttttggatat tgagattcga aatgaagaga tgaagggact ggaagtggct
     1501 agaaagattc gggatcggga tccttatgcc ctgattgtct ttgtgacgac tcactcggag
     1561 tttatgcccc tgtcttttcg ctaccaagtg tctgctttgg actacattga taaggccttg
     1621 tcagcagagg agtttgaatc tcggatcgag acagccctcc tctatgccaa tagtcaagat
     1681 agtaaaagtc tggcggaaga ttgcttttac tttaaatcaa aatttgccca atttcagtat
     1741 ccttttaaag aggtttacta tctcgaaacg tcgcccagag cccatcgtgt tattctctat
     1801 accaagacag acaggctgga atttacagcg agtttagagg aggttttcaa gcaggagccc
     1861 cgtctcttgc agtgccaccg ctcttttctc atcaatcctg caaatgtggt gcatttggat
     1921 aagaaagaaa aactgctttt ctttcccaat ggtggaagtt gtctaatcgc ccgttataag
     1981 gtcagggaag tgtctgaggc tattaataac ttacactgag ctaggagaat ttatgaacat
     2041 tgcttggata ttgttgtata cacttgttac taatggacta gaaattgtca tcttctttaa
     2101 ggtggatgga attgatctta ctttcgagag gatttttaag gcctttcttt ttaagatact
     2161 gttggccttt gtttttgtga tgattagcta tatagtagga aatgtttacc tatcttattt
     2221 tatggaaccc ttgtacggca taggcttatc tttcttatta ttgagagggc ttcctaaaaa
     2281 actccttttc ttttatggtc tctttccaat gatattggtg aatctctttt atagaggagt
     2341 ctcctatttt gtgcttccat ttttgggaca agggcaagta tatgatggct actcatttac
     2401 tgggttatgt ataataattt tcaatttctt catttctcta gcttttttga aatggttgga
     2461 ctacgatttt actagcttga gaaaggagat tctcgataaa gcctttcaaa agtccctgac
     2521 tcagattaac tggataatgg gtggctacta tctagtcatg gaaagtctgt ctttttttga
     2581 atatgaacaa agtattcaat caaagactgt tcgccatctc atcctagtct tttacctact
     2641 cttttttatg ggggttatca agaaattgga tacctatttg aaggaaaaac tctatgagag
     2701 attggaacaa gagcaggccc tgcgctatag agatatggaa cgctatagtc ggcatataga
     2761 ggagctttac aaggaagtac ggagttttcg ccatgattat accaacctct tgactagctt
     2821 acgtctgggc attgaagagg aggatatgga gcagataaaa gaggtctatg gctccgtctt
     2881 aaaggattcc agtcagaaat tgcagaacaa taaatatgac ctgggcagat tggtaaatat
     2941 tcgtgataaa gccctcaaaa gtcttctagc agggaaattt ttaaaagcca gagataagaa
     3001 cattgtcttt aatgtcgaag ttcctgagga gattcaggtc gaggggatga gtctacttga
     3061 ttttctaacc attgtgtcta tcctttgtga caatgctatt gaagccagtg tggaagctag
     3121 tcaacctcat gtttcaatcg cctttttaaa aaatggagca caggagacct ttatcatcga
     3181 aaactccatc aaagaagagg gcatcgatat ttctgaaatc ttctcctttg gagccagttc
     3241 taaaggggag gagagaggag ttggtctcta taccgtcatg aagattgtgg aaagccatcc
     3301 taataccagt ctaaatacca cctgtcaaaa tcaagtcttt cgtcaggtac ttactgtgat
     3361 acatacagaa tgatgaaaaa taagaccgag agtacttgtt tctcggtctt atttttttat
     3421 agttgtattg gatgatgaag ttcttatgtg atgtaatgag catatctatt aatgttatat
     3481 aataaatctt cccacaatcc tccacctgta atttggttga gttcggtagt tgttagttct
     3541 tgaaatgaag ttaggttttg tttcttatcc atgttatgat tctccttttt gataagataa
     3601 taaatagtta tagagtgtta tctgaaaatt aatcagaatg tgttaaaatt ttatctttga
     3661 aataatcaaa atatgttttc tttgtagtta cactagtgac gcgaccttgt aagccatatt
     3721 ggatgagttt actatcctcg ttagatagtt ttgcaagagc ggttaattta aagagatttc
     3781 cttgctctgt tctggtagga gtttgatcaa ttgtctgaag ttggccgatg atggtggtgc
     3841 cgtgatttcc aatcttctcc agttttaatc ttacagtttg tcctttatct agtagaggta
     3901 gatagtcaga agatacgtag taagtgatta gtacttctct tgtatctgtg atgacaggga
     3961 atatttgagc aatttctgta ccagttggaa ttctattttt accttcaaat tcgctgttca
     4021 gatgaacgat acctttactt ggggaggtta aggtattgtt ttccaaacgc tgtgtggctt
     4081 gatctagttg tacttttaat tctgttaatt gattctccac agttagttgt tgctgtgagg
     4141 ctgtctgtaa aaactgagtg cggagtactt caattttggt tgctaaactg ttatcataag
     4201 ttgctacact tccgatacca gcttgctgaa ttttgaggct tgcgatagat gattcaagac
     4261 ctgcaatact ttgattaatt tgagataaaa atggctcctc tgcagttcct tgtgtttgtc
     4321 cttgtgaggc tacaagataa cgattcaaaa ttgactggtg cggattgcca gttggtaagc
     4381 gtgctctgtt atttatgata gcatctctca actcttgata ttctccaatt tgttgttgaa
     4441 cttttgtaat ttcttgttca atagctgatg aactgctatt ggaaagatta gcttgatttg
     4501 aaacttcggt gttagtcttt gtgataccca gttcaatatc atgggattgt ttagtaaaat
     4561 tcataaaggt attatggtag ccaaattcat cctcgccaga aaaaagatca gtcgttgttt
     4621 ctaagctttg tttcaaaatt ccaagtcctt ctttttgctt ctcaagtctt tgtaattgag
     4681 ttgctaaggc agttttctga ctttcttcca ttgtttcaga gtatttgatg agtaagtcac
     4741 ctttctcaac tacttgattt gccactaaat aattagcaag gataggatta tcactggtcg
     4801 actgaataga tgcaatgaca cttgtagggg cgatttctcc ttgggaagta acagtaattt
     4861 cttttgtggc aacaagggag aaaatcaaga tgaaagtaaa cagtaatgaa agaggtataa
     4921 ttaacactgt cgcatagtta tggtaacgtc tctgataaaa ctcgacgctt ctaaaaagat
     4981 taggattcat gacattctcc ttatttattg aatagatgat ggtagaagct ttgcgcctgc
     5041 attaactctt ggtgactacc aacttcaatg attttcccct ggtcaagaac aatgacacgg
     5101 ttggttcgtt cggctatact gagacgatgg gctacaaaga gaatggtttt atcagttagg
     5161 gatataagat tatctataac ctttttctca gtcaagacat caagaccgct agtagcttca
     5221 tctagtatta aaacaggagc tttagttaaa agagcacgag cgagagcgat tcgttgcttt
     5281 tgtcctcctg atagaccagc tccatcagag agctgagttt gatagcccat aggcattctt
     5341 tcaatgtctt gacgaatttc agctaattca caagctttta gaatatcttc ttggctaatc
     5401 atatgattac cgcccaaggt taagttttcc aaaatagagc cattaaagat ataggcttgt
     5461 tggggtaggt aattaatatg acggcgcaag acttttttat caatgttttt aatatcctga
     5521 tgattgatgg aaatatgccc tttgtagggt tcaaagaaat tgacaatcat tttggctaaa
     5581 gttgttttac cagaaccact aactccaact aggctaacct tatctccttg tttaatcgtg
     5641 agattaatat ctgttaaggt atctcgtcca aaaccatact tataagaaag gtcatcaaat
     5701 tcaatatcgc ccatcaaaaa atgtgaatga acagggtttt cttgaacttg aaattcagat
     5761 tcgactagat agacttcgtt caaacggtta ttagcgacct tcgcagattg gagtttggtt
     5821 tggaggttga taatattttc cataggagtt gtaaagtaag aaaaaagtgt gttaaaggta
     5881 atcagctgac cgatagaaat tttactcgac atgactaatt gagcgccaaa ccataggata
     5941 aggatattca gaactaattt tgttccctgc tttaaactcg tttgtaaaat agaatattta
     6001 ctgagcttaa aggatttttc caaataatct acaaattcgc tgtctatatt ttgatagcga
     6061 ttttcttcac tcgtgagcga ctttatagtt tcaatcccgt tgatatcttc gataatggca
     6121 gagctaacca tagaattact ttgcatgaca tcatggttca ttttttcaaa aggtttcata
     6181 cccaaatttc aagttgaagt tagccaccca aaagaaattc acttggcgac ttgtagtcca
     6241 agcatttttt agg
//
