LOCUS       NZ_CMIW01000001         7561 bp    DNA     linear   CON 27-NOV-2024
DEFINITION  Streptococcus pneumoniae strain SMRU3003, whole genome shotgun
            sequence.
ACCESSION   NZ_CMIW01000001
VERSION     NZ_CMIW01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001092805.1-RS_2024_11_27
            Annotation Date                   :: 11/27/2024 00:58:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,159
            CDSs (total)                      :: 2,109
            Genes (coding)                    :: 1,938
            CDSs (with protein)               :: 1,938
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 171
            CDSs (without protein)            :: 171
            Pseudo Genes (ambiguous residues) :: 0 of 171
            Pseudo Genes (frameshifted)       :: 69 of 171
            Pseudo Genes (incomplete)         :: 100 of 171
            Pseudo Genes (internal stop)      :: 55 of 171
            Pseudo Genes (multiple problems)  :: 44 of 171
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:52:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7561
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CMIW01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..7561
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     gene            <1..202
                     /locus_tag="AD046_RS12700"
     cand_cluster    1..7561
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7561
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[407:2561](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      408..2561
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     CDS             <3..202
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018372120.1"
                     /locus_tag="AD046_RS12700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_050115854.1"
                     /transl_table=11
                     /translation="SLFIIGHMGLFFYTKIGSIISIVDLPTTNIIEPYFLGRTFVLPIF
                     LSKKCSWEGDRLIWEGSPVFV"
     gene            408..2561
                     /gene="comA"
                     /locus_tag="AD046_RS00010"
                     /old_locus_tag="ERS022513_00001"
     CDS             408..2561
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="AD046_RS00010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_00001"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_000668293.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.8e-43, bitscore:
                     140.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1125.2,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            2574..3923
                     /gene="comB"
                     /locus_tag="AD046_RS00015"
                     /old_locus_tag="ERS022513_00002"
     CDS             2574..3923
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="AD046_RS00015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_00002"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_050115856.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGTSLAGQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAEINLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            4093..4800
                     /gene="purC"
                     /locus_tag="AD046_RS00020"
                     /old_locus_tag="ERS022513_00003"
     CDS             4093..4800
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312208.1"
                     /locus_tag="AD046_RS00020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS022513_00003"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043300.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQELK"
     gene            4811..4945
                     /locus_tag="AD046_RS13205"
     CDS             4811..4945
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429437.1"
                     /locus_tag="AD046_RS13205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000429436.1"
                     /transl_table=11
                     /translation="MENLRLSTKRTQAEKVPQTFSLCRELGELTDVYEIVWEKLQGLK"
     misc_feature    complement(5016..5029)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     misc_feature    5727..5741
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    6487..6497
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 gtcgcttttc attataggtc atatgggact ttttttctac acaaaaatag gctccataat
       61 atctatagtg gatttaccca ctacaaatat tatagagcca tattttctag gtagaacgtt
      121 tgttctgcct atttttttat ccaaaaagtg cagttgggag ggagataggc tcatttggga
      181 aggaagtcca gtttttgttt agggattggg gtaagatagt tgttatcaga tgagtttata
      241 ctcttcgaaa atcaaattca aaccacgtca acgtcgcctt gccgtatata tgtgactgac
      301 ttcgtcagtc ctatctacaa cctcaaaaca gtgttttgag cagcctacgg ctagtttcct
      361 agtttgctct ttgattttca ttgagtatta gggaaaagga gatgaatatg aaatttggga
      421 aacgtcacta tcgtccgcaa gtggatcaga tggactgcgg tgtagcttca ttagccatgg
      481 tttttggcta ctatggtagt tattattttt tggctcactt gcgagaattg gctaagacga
      541 ccatggatgg gacgacggct ttgggcttgg tcaaggtggc agaggagatt ggttttgaga
      601 cgcgagccat taaggcggat atgacgcttt ttgacttgcc ggatttgact tttccttttg
      661 ttgcccatgt gcttaaggaa gggaaattgc tccactacta tgtggtgact gggcaggata
      721 aggatagcat tcatattgcc gatccagatc ccggggtgaa gttgactaaa ctgccacgtg
      781 agcgttttga ggaagaatgg acaggagtga ctctttttat ggcacctagt ccagactata
      841 agcctcataa ggaacaaaaa aatggtctgc tctcttttat ccctatatta gtgaagcagc
      901 gtggcttgat tgccaatatc gttttggcaa cactcttggt aaccgtgatt aacattgtgg
      961 gttcttatta tctgcagtct atcattgata cctatgtgcc agatcagatg cgttcgacac
     1021 tagggattat ttctattggg ctagtcatcg tctacatcct ccagcaaatc ttgtcttacg
     1081 ctcaggagta tctcttgctt gttttggggc aacgcttgtc gattgacgtg attttgtcct
     1141 atatcaagca tgtttttcac ctccctatgt ccttctttgc gacacgcagg acaggggaga
     1201 tcgtgtctcg ttttacagat gctaacagta tcatcgatgc gctggcttcg accatccttt
     1261 cgattttcct agatgtgtca acggttgtca ttatttccct tgttctattt tcacaaaata
     1321 ccaatctctt tttcatgact ttattggcgc ttcctatcta cacagtgatt atctttgcct
     1381 ttatgaagcc gtttgaaaag atgaatcggg ataccatgga agccaatgcg gttctgtctt
     1441 cttctatcat tgaggacatc aacggtattg agactatcaa gtccttgacc agtgaaagtc
     1501 agcgttacca aaaaattgac aaggaatttg tggattatct gaagaaatcc tttacctata
     1561 gtcgagcaga gagtcagcaa aaggctctga aaaaggttgc ccatctcttg cttaatgtcg
     1621 gcattctctg gatgggggct gttctggtca tggatggcaa gatgagtttg gggcagttga
     1681 ttacctataa taccttgctg gtttacttta ccaatccttt ggaaaatatc atcaatctgc
     1741 aaaccaagct tcagacagcg caggttgcca ataaccgtct aaatgaagtg tatctagtag
     1801 cttctgagtt tgaggaaaag aaaacagttg aggatttgag cttgatgaag ggagatatga
     1861 ccttcaagca ggttcattac aagtatggct atggtcgaga cgtcttgtcg gatatcaatt
     1921 taaccgttcc ccaagggtct aaggtggctt ttgtggggat ttcagggtca ggtaagacga
     1981 ctttggccaa gatgatggtt aatttttacg acccaagtca aggggagatt agtctgggta
     2041 gtgtcaatct caatcagatt gataaaaaag ccctgcgcca gtacatcaac tatctgcctc
     2101 aacagcccta tgtctttaac ggaacgattt tggagaatct tcttttggga gccaaggagg
     2161 ggacgacaca ggaagatatc ttacgggcgg tcgaattggc agagattcga gaggatatcg
     2221 agcgcatgcc actgaattac cagacagaat tgacttcgga tggggcagga atttcaggtg
     2281 gtcaacgtca gagaatcgct ttggcgcgtg ctctcttgac agatgcgccg gtcttgattt
     2341 tggatgaggc gactagcagt ttggatattt tgacagagaa gcggattgtc gataatctca
     2401 tggctttgga caagaccttg attttcattg ctcaccgctt gactattgct gagcggacag
     2461 agaaggtagt tgtcttggat cagggcaaga ttgtcgaaga aggaaagcat gctgatttgc
     2521 ttgcacaggg tggcttttac gcccatttgg tcaatagcta gaaagaggag aggatgaaac
     2581 cagaattttt agaaagtgcg gagttttata atcgtcgtta ccataatttt tccagtagtg
     2641 tgattgtacc catggccctt ctgctcgtgt ttttacttgg ctttgcaact gttgcagaga
     2701 aggagatgag tttgtccact agagctactg tcgaacctag tcgtatcctt gcaaatatcc
     2761 agtcaactag caacaatcgt attcttgtca atcatttgga agaaaataag ctggttaaga
     2821 agggggatct tttggttcaa taccaagaag gggcagaggg tgtccaagcg gagtcctatg
     2881 ccagtcagtt ggacatgcta aaggatcaaa aaaagcaatt ggagtatctg caaaagagcc
     2941 tgcaagaagg ggagaaccac tttccagagg aggataagtt tggctaccaa gccacctttc
     3001 gcgactacat cagtcaagca ggcagtctta gggctagtac atcgcaacaa aatgagacca
     3061 tcgcgtccca gaatgcagca gctagccaaa cccaagccga aatcggcaac ctcatcagtc
     3121 aaacagaggc taaaattcgc gattaccaga cagctaagtc agctattgaa acaggtactt
     3181 ccttggccgg tcagaatcta gcctactctc tttaccagtc ctacaagtct cagggcgagg
     3241 aaaatcccca aactaaggtt caggcagttg cacaggttga agcacagatt tctcagttag
     3301 aatctagtct tgctacttac cgtgtccagt atgcaggttc aggtacccag caagcctatg
     3361 cgtcagggtt aagcagtcaa ttggaatccc ttaaatccca acacttggca aaggttggtc
     3421 aggaattgac ccttctagcc cagaaaatct tggaggcaga gtcaggtaag aaggtacagg
     3481 gaaatctttt agacaagggg aaaattacgg caagtgagga tggggtgctt catcttaatc
     3541 ctgagaccag tgattctagc atggttgcag aaggtgccct actagcccaa ctttatccat
     3601 ctttggaaag agaagggaaa gccaaactca cagcctatct aagttcaaaa gatgtagcaa
     3661 gaatcaaggt cggtgattct gttcgctata ctacgactca tgatgccggg aatcaacttt
     3721 ttctagattc tactattaca agtattgatg cgacagctac taagactgag aaagggaatt
     3781 tctttaaaat cgaggcggag attaatctaa cttcggagca ggctgaaaaa cttaggtacg
     3841 gggtggaagg ccgtctacag atgattacgg gcaagaaaag ttatctacgt tattatttgg
     3901 atcaattttt gaacaaagag taatgttcgt gtttttagag ttaaataatt tttaaactgt
     3961 gagaaagatt cttcttgcag ttttttcttt acaatttttg aaaaacatct gctatttatt
     4021 cggttaaatt cttgtgtttt ttggtttttt gtggtaaaat gtgctcaagt aatacgaaag
     4081 gcgaacttta aaatgtcaaa acaattgatc tattcgggaa aagctaaaga tatctataca
     4141 actgaggatg aaaatcttat tatttcaact tacaaggacc aggcgactgc tttcaacggt
     4201 gtcaagaagg agcagattgc aggtaaggga gtcttgaata atcagatctc atcttttatt
     4261 tttgagaaat taaatgcggc tggtgtggcg actcactttg tggagaaact ttcagacacg
     4321 gaacaactca ataaaaaggt taagattatt cctttggaag tcgtgctccg caactatact
     4381 gctggttcct tttcaaaacg ttttggtgtg gatgagggaa tcgccttgga gactccgatt
     4441 gtcgaatttt actacaaaaa tgatgatttg gatgatccat ttatcaatga tgagcatgtg
     4501 aaattcctac agattgcgga tgaccagcag attgcctact tgaaggaaga aacgcgtcgt
     4561 atcaatgaac tattgaaagt ctggtttgct gagattgggc ttaaattgat tgactttaag
     4621 ctagagttcg gttttgacaa ggatggcaag attatcttgg cagacgaatt ttcaccagat
     4681 aactgccgct tgtgggatgc tgatggcaac cacatggata aggatgtttt ccgtagagga
     4741 ttgggagaac taaccgacgt ttatgagatt gtttgggaaa agttgcagga attgaaataa
     4801 tctgtttgca atggaaaacc ttcgtctctc aactaaaagg actcaggctg aaaaggtccc
     4861 ccagaccttt tcactctgta gagaactagg tgaactaaca gatgtttacg aaattgtctg
     4921 ggaaaagttg cagggtttaa aataacaacc tcaaggctgt ttgggaatat tgcaagagct
     4981 gaaataaagg aataagaatt gatggataaa cgtatttttg ttgaaaaaaa ggctgatttt
     5041 caggtcaagt cagagagttt ggttagagag ctccagcaca acttgggact gtcaagcttg
     5101 aaaagtattc gtattgtgca agtatatgat gtatttgact tggctgagga cttgtttgca
     5161 cctgcagaga agcacatttt ctctgagcag gtaaccgacc atgttttaga tgaagtatct
     5221 gtgcaggcgg atcttgctaa ctatgctttc tttgccattg aaagtctgcc agggcagttt
     5281 gaccagcgtg cagcttcgtc acaggaagcc ttgcttttgt tgggaagttc gagtgacgtg
     5341 acagtcaaca cagcccaact ttacttggtg aataaagata ttgatgcgac tgagttggaa
     5401 gctgtcaaaa actacctgct caatccagtt gattctcgtt tcaaggatat cacgacaggg
     5461 attgccaagc aggagttttc agagtcagac aagatcattc caaaattgac tttctttgaa
     5521 agctatacag cagaagactt tgctcgctac aaggccgaac aagggatggc catggaagtg
     5581 gatgatttgc tctttatcca agactacttt aagtcaatcg ggcgcgtgcc aactgagact
     5641 gaactcaagg ttttggacac ttactggtct gaccactgcc gtcatacgac ttttgagaca
     5701 gagttgaaac acatcgactt ttcagcttct aaatttcaaa agcaattgca gtcaacctat
     5761 gacaagtata ttgccatgcg cgaggaatta ggtcggtctg aaaaaccaca aaccttgatg
     5821 gatatggcga ctattttcgg tcgttatgag cgtgctaatg gacgattgga tgatatggaa
     5881 gtctctgacg aaatcaatgc ctgctcagtt gaaattgaag tggacgttga tggtgtcaag
     5941 gaaccttggc ttctcatgtt taaaaacgaa acccacaacc atccaacaga aattgagcca
     6001 tttggtggag cggctacctg tattggtgga gctattcgtg atccgttgtc aggccgttcc
     6061 tatgtttacc aagccatgcg tatttcaggt gctggtgata ttacagcacc gatttcggaa
     6121 actcgcgctg ggaaattgcc acaacaagtc atttctaaaa cagcagctca tggttattct
     6181 tcatatggta accagattgg gcttgcaaca acctacgttc gtgaatactt ccacccaggc
     6241 tttgtagcta aacgtatgga acttggtgcc gttgttggtg cggctcccaa gggcaatgtt
     6301 gtccgtgaaa aacctgaagc aggtgatgtg atcatccttc tcggaggcaa aacaggtcgt
     6361 gatggtgtcg gtggtgcgac gggctcttct aaggttcaaa cagttgagtc tgtagagact
     6421 gctggtgctg aggttcaaaa aggaaatgcc atcgaagaac gcaagattca gcgcctcttc
     6481 cgtaatggca atgtcactcg tctgatcaag aagtccaatg actttggggc aggcggtgtc
     6541 tgtgtggcta tcggtgaatt ggcagacggt cttgaaatcg acctcaacaa ggtgcctctt
     6601 aaataccagg gcttgaatgg tacagaaatt gccatctctg aatcacaaga acggatggcg
     6661 gtcgtggttc gtcctgaaga tgtggatgcc ttcgttgccg aatgtaacaa agaaaatatt
     6721 gatgctgttg tggtggcgac agtaactgaa aaaccaaatc ttgtcatgca ctggaatggt
     6781 gagacaatcg ttgacttgga gcgtcgtttc cttgacacca atggtgtgcg cgtggttgtc
     6841 gatgccaaag ttgtggacaa ggatgtcaaa ctcccagaag agcgtcaaac atctgctgaa
     6901 acactggaat cagataccct tacggttcta tctgacctca accatgcaag tcaaaaagga
     6961 ttacagactg tctttgactg ctctgttgga cgctcaacgg ttaatcaccc acttggtggt
     7021 cgttaccaac tcacaccaac tgaggcatct gtgcagaaat tgccagttca acacggtgtg
     7081 actcatactg cgtcggtcat tgctcaaggt ttcaacccat atgtagctga atggtctcca
     7141 taccacggtg ctgcttatgc ggttatcgaa gcaactgctc gtttggtggc tgctggtgcc
     7201 aactggtcta aggctcgttt ctcttaccaa gaatatttcg agcggatgga caagcaagca
     7261 gagcgttttg gtcagccagt agccgccctt ctaggctcta ttgaagctca gattcaactt
     7321 ggcttgccat ctatcggtgg taaggactcc atgtctggta cctttgaaga attgaccgtt
     7381 ccgccaacct tggttgcctt tggggtgacg acggcagata gccgtaaggt gctctctcca
     7441 gaatttaaag ctgttgggga aaatatctac tacatcccag gtcaagccct ctctgcagag
     7501 attgattttg acttgattaa gaaaaatttt gctcagtttg aagccatcca agctgaccat
     7561 a
//
