LOCUS       NZ_JVCZ01000014        20876 bp    DNA     linear   CON 16-JUN-2024
DEFINITION  Streptococcus parasanguinis strain 540.rep1_SPAR, whole genome
            shotgun sequence.
ACCESSION   NZ_JVCZ01000014
VERSION     NZ_JVCZ01000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus parasanguinis
  ORGANISM  Streptococcus parasanguinis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 155602)
  AUTHORS   Roach,D.J., Burton,J.N., Lee,C., Stackhouse,B., Butler-Wu,S.M.,
            Cookson,B.T., Shendure,J. and Salipante,S.J.
  TITLE     A Year of Infection in the Intensive Care Unit: Prospective Whole
            Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic
            Transmissions and Novel Microbiota
  JOURNAL   PLoS Genet 11 (7), e1005413 (2015)
   PUBMED   26230489
  REMARK    Erratum:[PLoS Genet. 2017 Apr 14;13(4):e1006724. doi:
            10.1371/journal.pgen.1006724. PMID: 28410416] Publication Status:
            Online-Only
REFERENCE   2  (bases 1 to 155602)
  AUTHORS   Salipante,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2014) Laboratory Medicine, University of
            Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABYSS v. 1.3.5
            Genome Coverage                   :: 13x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001071295.1-RS_2024_06_16
            Annotation Date                   :: 06/16/2024 18:04:27
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,247
            CDSs (total)                      :: 2,184
            Genes (coding)                    :: 2,147
            CDSs (with protein)               :: 2,147
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 8, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2 (5S, 23S)
            partial rRNAs                     :: 8 (16S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 15 of 37
            Pseudo Genes (incomplete)         :: 21 of 37
            Pseudo Genes (internal stop)      :: 7 of 37
            Pseudo Genes (multiple problems)  :: 5 of 37
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:49:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 21159
            Orig. end                         :: 42035
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JVCZ01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20876
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10876](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10876
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(270..283)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.24"
                     /tool="antismash"
     misc_feature    complement(329..345)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.94"
                     /tool="antismash"
     gene            1076..1978
                     /locus_tag="ADG88_RS02365"
     CDS             1076..1978
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032537.1"
                     /locus_tag="ADG88_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_014712989.1"
                     /transl_table=11
                     /translation="MSEKNKVETKKKERLKENIMGYSFLAPALILLFIFLVIPVGMVIY
                     YAFTDYYLLTPEDRKFVGLQNFMRLAQDPIFIKSFLNTLKFVVWIIPVQLGAALGMALI
                     VNKKRKGNMFFKVAFFAPVVMSLVVISILWLYLLNPNNGLLNALLNKIGISSQPFLTSP
                     KQAMYAIVFVSAWQGAGYQMLLFLGGMQNIPQDIYEAAELDGFSKWAQFRYITMPLLKP
                     TALFVLLTTLISAFKLIVQPMVMTQGGPLNSTITMVYYIYQQGFTDRLVGYSSSIALVF
                     TTLIGMISLVQRRVLKEDD"
     gene            1980..2825
                     /locus_tag="ADG88_RS02370"
     CDS             1980..2825
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819520.1"
                     /locus_tag="ADG88_RS02370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_161800641.1"
                     /transl_table=11
                     /translation="MKRLKPTTILEYVLLILLAGLFLFPMIWMVVSAMKPEADVYKNLT
                     SWKAFLPSFNPADWFKPYQEVLARFSILTYLGNSIFYAGTFALGSIIVNALAGFAFAKI
                     NFTGKKILFGFLLALLIIPMETVLIPQFTIINSLGLVNNRLAVIIPGLASVFNIYLFRN
                     FFIAIPEEIIESAKIDGASILRIFFKIMLPMSKPAVATVGVLSFISSWNDYIWPLMVLT
                     DSSKFSMQVAITTINTTQPVYINQVMAVLTISTIPLILVYIVAQKYIIQGLGGSGTGIK
                     "
     gene            2835..4289
                     /locus_tag="ADG88_RS02375"
     CDS             2835..4289
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017573.1"
                     /locus_tag="ADG88_RS02375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="WP_049474225.1"
                     /transl_table=11
                     /translation="MKESIRKANQYIDENRVKVNQQYRGAFHLLPPIGWMNDPNGFVYF
                     LGEYHLFYQFYPYDSVWGPMHWGHAKSKDLLHWEELPVALAPSESYDKDGCFSGSAIVK
                     DDKLYLLYTGHVDDEEKREETQCLAVSTDGITFEKIPTNPVIHAQHIEGIADIADFRDP
                     KVFEYQGNYYAVVASKTPDDRGQILLFASSNLVDWTFTSVLLEGEKGQGIMWECPDFFP
                     LDGKWVLILSPIEMERQQEKYWNLNSTVAFIGDMNWETGRFHVDSYDEIDGGLDFYAPQ
                     TCQGPNGERYMVAWMQMWHRSIPSHDLAHRWAGSMTLPRKLSLKDGRLVQELPESVKEH
                     FLVKHFPETIVKGNQITIPAREKQTLFELDAKPGRSFILGYGDETDPDCVLQLIYDASQ
                     KRFSLSRDQFGHPISGKEDPAFQSRWIQLDAEKDHHFSIIRDTNSIEVFVDGKTLSMTF
                     YETSQNPVYTLTADEGVDWVVKTYQK"
     gene            complement(4346..5620)
                     /locus_tag="ADG88_RS02380"
     CDS             complement(4346..5620)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002962148.1"
                     /locus_tag="ADG88_RS02380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-hydroxycarboxylate transporter family protein"
                     /protein_id="WP_049474226.1"
                     /transl_table=11
                     /translation="MKKLNEINISGVSLPLYAFIVIVLAVTIAMGKLPLNMLGLTLLLV
                     VMGHFLYFIGEKLPIMNSYLGGGSVFTLLGATLLATFHVIPANIITATKGFLGDSFGFL
                     DFYIAALICGAILGMNRNLLVKASARFIPVSLVTMVIGALSVGIVGSLLGQGFGHSILY
                     VSFPQMVGGMGAGILPLSKIYAANLHGSQAAIFSQLAPATTLGNILAIIGAVLIVKVFA
                     DSPYNGHGVLIPVNKDELKKEKLTLDPTQIGVGMMFAFSIFLLGVICNAFVPKIHSYAF
                     MIIIVFILKAFNAVPKPLENCVVMFNQVIMTNLTHAVLAGIGLSLIDLSTLAKAMTWQF
                     ILLSLTSVLAMGLASAVIGKLVGLYPVETAIGSGMINNSMGGTGNIAVLSASDRMEMIA
                     FAQMANRLSGAIILILGGLLASVLS"
     gene            complement(5642..7264)
                     /locus_tag="ADG88_RS02385"
     CDS             complement(5642..7264)
                     /EC_number="4.1.1.101"
                     /GO_function="GO:0043883 - malolactic enzyme activity
                     [Evidence IEA]"
                     /GO_process="GO:0043464 - malolactic fermentation [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002962147.1"
                     /locus_tag="ADG88_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malolactic enzyme"
                     /protein_id="WP_049474227.1"
                     /transl_table=11
                     /translation="MKSHEILNNPFLNKGTAFTMEERKELGLIGLLPPYVQTIEEQAEQ
                     AYQHFLRKPSDLEKRLFLMEIFNTNRTLFYYLFNQHIVEFNPIVYDPVIADTIEQYSEL
                     FVDPQYAAYLDINHPENIEEILKNAAGDRDIRLIVATDAEGILGIGDWGVQGVDISVGK
                     LMVYTAAAGIDPACVMPLVIDAGTNREELLNNPMYLGNRHERVRGEKYDAFIDQFVQTA
                     GKLFPKLYLHWEDFGRSNAADILNRYKKEIPTFNDDIQGTGIVVLGGIFGAMDITGEKL
                     TDQVYLCYGGGSAGAGIADRVHAEMVAEGLSPEEAYKRFFMIDKQGLLFDDMEDLTPAQ
                     KPFAKKRADFEGKGDMTNLLEVIKTVKPTILVGTSTNPGAFTKEVVEAMCENTERPVIF
                     PISNPTKKLEATAQQVIEWSDGKAFVATGVPSGTISYKGVDYEIGQANNALIYPGLGLG
                     MLASEAKLLTDEMIGAAAHSLSGIVNSGQPGAPVLPPFQYVADVSIKVAEAVAKKAQEQ
                     GLAQAKETDMAKAVRDLKWYPKY"
     gene            7437..8321
                     /locus_tag="ADG88_RS02390"
     CDS             7437..8321
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017577.1"
                     /locus_tag="ADG88_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_049474228.1"
                     /transl_table=11
                     /translation="MNIRDLEYFYQLSKLKSYTDVAHYFQVSQPTVTYAIKRLEDHYAC
                     QLVEKSSSNRVLHLTQPGKVLANHAREVLIEIEKTEKAVERSKKNLLRIGLPPLITSDI
                     MKKFGTHDEELEIFRQSQLVQLGSRDLMRLLVRGDLDFSLLGSLEPISHAHLTSQLLYK
                     KEFFVIVSKDHPLADRKEISFKEVLKETFILLDEHHVHMTAFKHLNARFDDLAQSTVVL
                     TDSNLVLSFIEENLGIGLMTDLTLFPEYPNLVKIPLVEEEKTVFYISYAYPNEGEPQAL
                     LSSFIERLEKCEK"
     gene            8474..9814
                     /gene="xseA"
                     /locus_tag="ADG88_RS02395"
     CDS             8474..9814
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /locus_tag="ADG88_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_049474229.1"
                     /transl_table=11
                     /translation="MSNYLSVSSLTKYLKLKFDKDPYLERVYLTGQVSNFRKRPNHQYF
                     SLKDEKAVIQATVWAGVYRSFGFELEEGMKINVIGRIQLYEPSGSYSIVIEKAEPDGVG
                     ALAIQFEQLKKKLTEEGLFQDRWKQALPQFPRKIGVITSQSGAVIRDIITTVSRRFPSV
                     EIVLYPTKVQGEGASSEVVANIQRANQRDDLDVLIIGRGGGSIEDLWAFNEEAVVRAIF
                     ESRIPIISSVGHETDTTLADFVADRRAATPTAAAELATPVTKLDLLSHLQKQENRMATA
                     MSNRLAYNRERLAKLSQSVIFRQPERLYDGYLQKIDQLQLRLKQGMRDAYGQGANQLQG
                     LRHRLEAMSPLHRIERYQDRLLQDKRILTNRMEQVLKEQKIKVQGLSEALLMLDTSRII
                     ARGYAMVKQDDQVLDSVAKVKEGDPLSLIMRDGQLEVEVKHVERKEI"
     gene            9792..10004
                     /locus_tag="ADG88_RS02400"
     CDS             9792..10004
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004219945.1"
                     /locus_tag="ADG88_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_003006013.1"
                     /transl_table=11
                     /translation="MSKEKKFEENLADLEAIVQKLESGDVALEEAITEFQKGMKLSKEL
                     QDTLDQAEKTLVKVMQADGTEADLA"
     gene            10001..10876
                     /locus_tag="ADG88_RS02405"
     CDS             10001..10876
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732419.1"
                     /locus_tag="ADG88_RS02405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_049474230.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.2e-53, bitscore:
                     172.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQEEKRNRVEQAVRSFYEEKAVALHLVESVLYSVQAGGKRLRPL
                     LLLELLEAFGQELTEAHFQVAGALEMIHTGSLIHDDLPAMDNDDYRRGQLTNHKKFGED
                     LAILAGDALFLDPFGLIAASALPDAVKVSLILELSDASGSRGMVAGQVLDMEGEHKQLT
                     LAELQTIHANKTGRLLAYPFIAAGLILELQADIAQLLEKIGKKLGLAFQVRDDILDLVA
                     DFEALGKTPQKDLVAEKSTYPALLGLEESKALLTSELDACEDLLDQITAACDFDPRAIK
                     KLIEGLRIDG"
     gene            10869..11687
                     /locus_tag="ADG88_RS02410"
     CDS             10869..11687
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014712995.1"
                     /locus_tag="ADG88_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_049474231.1"
                     /transl_table=11
                     /translation="MAKERVDVLAYKQGLFDTREQAKRGVMAGLVVAVINGERFDKPGE
                     KIDEATELKLKGEKLKYVSRGGLKLEKALNQFGLSVEGKIAIDIGASTGGFTDVMLQNG
                     ASQVFSVDVGTNQLAWKLRNDPRVVSMEQFNFRYAEPDDFEATPSFASIDVSFISLDLI
                     LPALHRILAENGQVVALVKPQFEAGREQIGKNGIIKDPKIHLAVLEKVAAFAGIHGFAV
                     MGVDYSPIQGGHGNIEFLMYLEKKEEKTKPTSEQLEAVVELAHKEFKHEE"
     gene            11677..12111
                     /locus_tag="ADG88_RS02415"
     CDS             11677..12111
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732421.1"
                     /locus_tag="ADG88_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arginine repressor"
                     /protein_id="WP_003006022.1"
                     /transl_table=11
                     /translation="MKSKNIRLEKIRRFIRDHEVGTQEEIVEHLKEEGISATQATVSRD
                     IKELGIVKRPLKDMTYVYELPRKHHQGIGMIESNILSHRRMGEYVNFTMVPGTAPLVKR
                     RLREIYKEHIFSIVADDDTILLIAYSAPEAENILKSIFGW"
     gene            12118..13776
                     /gene="recN"
                     /locus_tag="ADG88_RS02420"
     CDS             12118..13776
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896130.1"
                     /locus_tag="ADG88_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA repair protein RecN"
                     /protein_id="WP_049474232.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIEEISLNFEKGMTVLTGETGAGKSIIIDAMNMM
                     LGSRATTDVIRHGAPKAEIEGLFTVESNRHLTALFEEQGLEWTDELIIRREILQNGRSV
                     SRINGQMVNLSVLKAVGQHLVDIHGQHDQEELMRPQLHIAMLDEFGDTAFFQTKDAYRQ
                     TFEDYKRLRKQVVELQRNQQENKARIEMLEFQIAEIEAAALEVDEDLRLEQERQRLLNH
                     KMIADTLTNAYTMLDAEDFSSLSNVRSAMNDLESIEEYDPSYKELSSQLSETFYALEDI
                     TKRLEDVVDGLEFDGNRLMQVESRLDLIHSITRKYGGQVKDVLEYLAQITKEYSLLTGS
                     DLSSEDLEKELKRLEKNLVTLAQDLSDQRHALAQALENEIQQELADLYMDKARFQVRFS
                     KAKFNREGNEAVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKEGKTSIVFD
                     EVDTGVSGRVAQAIAAKIHKIGQNGQVLAISHLPQVIAAADYQFYIEKISDEHSTVSTV
                     RLLNREERIEEIAKMLAGEDLTEAARQQAEQLLKR"
     gene            13797..14525
                     /locus_tag="ADG88_RS02425"
     CDS             13797..14525
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017584.1"
                     /locus_tag="ADG88_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_049474233.1"
                     /transl_table=11
                     /translation="MSTYFVVGDIHGKAQMLEELMTEWDGKAQLVFLGDLIDRGENSKR
                     SIEIVKDYVDHHGAVCLSGNHEYMFLAWLDNPEERYDHYRRNGGDTTINSLLGRPLDAP
                     VDGIADAQAVENAVPDLVAFIRSLPFDYETETYYFVHAGVDLTLENWRETSDYQKVWIR
                     KPFHEAENHTGKWIVFGHTPVYGLLNEPVGTENLWISDQKMGVDGGAVYGGVLHGLLLD
                     DHGIVHDHVLHNTGFSAADD"
     misc_feature    14563..14572
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            14615..15448
                     /locus_tag="ADG88_RS02430"
     CDS             14615..15448
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002925543.1"
                     /locus_tag="ADG88_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DegV family protein"
                     /protein_id="WP_049474234.1"
                     /transl_table=11
                     /translation="MANIKIVTDSSITIEPEVVEEYGITIVPLSVMVDGVLYSDSELGE
                     GDFLRLMQSSKNLPKTSQPPVGVFAEVYEKLAADGAHIVSIHMSHALSGTVEAARQGAT
                     LSGAEVTVIDSGFTDQAMKFQVVEAAKLAKEGADLDTVLARIEEVKEKTELYIGVSTLE
                     NLVKGGRIGRVTGLLSSLLNIRVVMEMKDHQLEPIVKGRGNKTFKKWLDELVEKLSHSK
                     VAEIGISYAGTPEWANEMKAQLQSLVEKAIPVLETGSIIQTHTGENAFAVLVRYE"
     gene            15559..15834
                     /locus_tag="ADG88_RS02435"
     CDS             15559..15834
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /locus_tag="ADG88_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_003006038.1"
                     /transl_table=11
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVDAVFAAVSEYLSKGEKVQL
                     IGFGNFEVRERAARKGRNPQTGKEIKIAASKVPAFKAGKALKEAVK"
     misc_feature    15835..15847
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     misc_feature    16192..16205
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.95"
                     /tool="antismash"
     gene            16290..16736
                     /locus_tag="ADG88_RS02440"
     CDS             16290..16736
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003002443.1"
                     /locus_tag="ADG88_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_003006041.1"
                     /transl_table=11
                     /translation="MNALHRHEEERVEEVLQNLRAKGIRITDTRRAVLSYLVASHEHPS
                     AEKIYRDLLPQFPSMSLATVYNNIKVLIDEGVVSEIKVRNDTTTYFDFMGHDHLNVVCE
                     KCGRIADVDIEVPDLREEAASQSGYQITKTQMTVYGICPDCQKN"
     misc_feature    16751..16765
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            16865..17869
                     /locus_tag="ADG88_RS02445"
     CDS             16865..17869
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ADG88_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_049474235.1"
                     /transl_table=11
                     /translation="MKKLENFSWKMWHVYTLIAVAVFFIGSLCSFFYVKDADYIVHERN
                     YIYVGKGQRLTNYEKVKGLDTGFPILALSLKNTDEDGYDDQIAVGHNYIAFQDSKLGNV
                     NQNEKDSEEYFKIRYYLIGEEKGEGHTIDVFKIIQKLGYKTIYGNMESTMYSDGKDEYV
                     RVKVTDKESIYFNLRTQKESKKRPKKTIQYGYKGIYRALSNPDFITKNFDEEESNTKIS
                     WPWVHYKQPKKKMTTTNDSSYSTSDSSEEKPEDSKLLSILKKYGFLLVLEEDRNLSSSQ
                     SLVSKLFPDATHFVWFIDDDYTRDGHNEYIHNIEELIQVVDEEKVEKVYGNEE"
     gene            17859..18653
                     /locus_tag="ADG88_RS02450"
     CDS             17859..18653
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ADG88_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_152903619.1"
                     /transl_table=11
                     /translation="MKNEKLKSCLVLVGFLALISICFYRNLETNIKGLYKSNHYPGEIK
                     ITSLSLSTQDKLGIDVNYVYSEKVNGKVISIPLKRRMKVEQFVIPYYPYLGKEGRYGMT
                     GDSIGMYAEEYSVYGPILEKALELNPDSKKLEQEIQNKINQNSTLKGSKITLKFTTFSQ
                     LSNYYRVRWLGEYEKESMKKNRTVLGGWYQFPVEDALEYNALYVQISLPKGVDKESIHL
                     KDELNTLLQKTSLPNGIYALDTSTELPTARAMIFNGKVKERD"
     gene            18656..19180
                     /locus_tag="ADG88_RS02455"
     CDS             18656..19180
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732429.1"
                     /locus_tag="ADG88_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_049474237.1"
                     /transl_table=11
                     /translation="MSEIQKDTGLSLAWELGLYIFLIFSFLALPFYNDLAISNPNNSQI
                     FLFLDNNPVFGGEAFEDLVNFYFIILLLLLVTLPILAFFIHNFFEKKGYPFLASLQSLL
                     IHVSCVVMFVYAVFSLSVQKDHYSFSSGFYVCLLIYLFHIYSNLRDIKKMIEYRNSATK
                     TANEAEILSKE"
     misc_feature    19236..19250
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            19345..20382
                     /locus_tag="ADG88_RS02460"
     CDS             19345..20382
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ADG88_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_049474238.1"
                     /transl_table=11
                     /translation="MKKLENFSWKIWHILSLVAVTVLMVGGIWSFLYLKEAVHVVSDRN
                     YDYVGRGQRLLENRIISEEATGIPILAYSFKKEDKNNAPYYTIGSQYIALQDSKLISGE
                     DKKKDANEYFRIRYYELGQEKGEGHTIDVLKLVQKMGYDSIEGNMRSSMFTDGKDEYVA
                     FNVTKNNLLFVNLNKGEIAETDPKMIVDYGYSGFYQILPAPKFETKKYSLDRNKIDVGG
                     CWIDYEYDDEDEKVETSSSSTERLDRNGVKVKDSKLLTLLKKYRHLLILKQNLTMEEEK
                     TVIKSLFPDADHFSWSISAPYTKSGQKEIVRNAEEFKKIIKEERVEEELEREFEKTFQE
                     GPDDD"
     misc_feature    20584..20595
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.67"
                     /tool="antismash"
ORIGIN
        1 gcctatgcaa aatcaaaagt gattgctcct ttggatgatt atctaaaaga cgataatatg
       61 gatgatgtac tggacagtat taaacaacag ggaacttatg atggtaaatt ttatgcattt
      121 ggttattcag aatccaatgt aggtgtttac tataataaga aaatgtttaa agaagcaggg
      181 attgacgaag ctagtttacc aaccctagaa aaaccatgga catggtctga gtttaatgcc
      241 attgctaaga aattaaaaga tcattttaac aaaccagcga ttgatttccg tttgaattca
      301 aacgatgaga tgttgccata tgcttacatg cctcttattt ggtcaaatgg tggatctgtt
      361 gtgaattcta aaggaacaaa agcggaaggc tacttcaata gcaaggaaag tgttgaagct
      421 gttcaattta ttcaagatct tgtgaaggat ggatatacga cagttagtcc tgttgaaaaa
      481 ggttttgaaa ccggtgaata tcctatggtt ctgagcggtt cttggacgat tgcagaccta
      541 caaacaaatt acaaagatat tgattttggt attcttcctt atccagtttc agataaaacg
      601 aagaaattgg tatcaccttc aggtagttgg caattagccg ttacaacaaa atctgataaa
      661 aaagaagcag ccgctgaatt tgttaagttt gctacaaata ctgaatctag tgaaattcta
      721 agcttaggta acagtgttct tccaatcaga aaatcaacaa ttaaaaatat taaggacaaa
      781 gtatctgagc caatgcgttt cttgatggaa caaaatgcta aaacggctca tgctcgtcca
      841 gttgtagtag cttatccaca agtttcacgc gctttccaac aagcaatgca agatatcagc
      901 tattataaag ataatccaga tgtacaaaaa gtattagatg ctcgtgcgaa agaaatgcaa
      961 acagcaatcg accaatcttt aaataaatag ttgacattca aaaaggtgga aggtaagtta
     1021 tggaatgtac cttccacctt attttattta atagtttcat cttaggagac gaacaatgag
     1081 cgaaaaaaat aaagtcgaaa caaaaaagaa agaacgcctt aaagaaaata ttatgggcta
     1141 tagcttttta gctccagctt taatattact tttcatcttt ttagtgatac ctgttggtat
     1201 ggtgatctat tatgccttta cagattatta cctattaacg cctgaggata gaaaatttgt
     1261 aggactacaa aattttatgc gcttagcaca agatccaatc tttataaaaa gcttcttgaa
     1321 taccttgaaa tttgtagttt ggattattcc agtgcaactt ggtgcggctc tcgggatggc
     1381 cttaattgtt aataagaaac gtaaaggaaa tatgttcttt aaggtagcat tttttgctcc
     1441 tgttgtgatg tctcttgtcg ttatttctat cctctggtta tacttgttaa atccaaataa
     1501 tggtttgctc aatgctctac tgaataaaat tggtatttct tcacaaccat tcttgacaag
     1561 tccaaaacaa gccatgtatg ctattgtatt tgtttctgca tggcagggtg caggttatca
     1621 aatgttgtta ttccttggag gaatgcaaaa tattccacaa gatatttatg aggcggcaga
     1681 gttggatgga ttttcaaaat gggctcaatt tagatatatc acgatgcctt tattgaaacc
     1741 aactgccttg tttgtactct tgacaacatt gatttcagca tttaaattga ttgtacaacc
     1801 aatggttatg actcaaggtg gtccattgaa ctcaacaatc actatggtat attacattta
     1861 tcaacaaggt ttcactgacc gtcttgttgg ttactcaagt tcgattgcct tagtatttac
     1921 aacattgatt ggtatgatta gtcttgtaca acggcgagtt ttgaaggagg atgattagga
     1981 tgaaacgttt aaaaccgact actattttag aatatgtttt attaattcta ttagcaggcc
     2041 tctttctatt tcctatgatc tggatggtgg tttcagcaat gaagccagaa gcagatgtgt
     2101 ataagaattt aacaagttgg aaagcattct tacctagttt taatccagct gattggttta
     2161 aaccttacca agaagttctt gcccgtttta gtattctaac atatctaggg aacagtattt
     2221 tttatgcagg aacatttgca cttgggtcta ttatagtaaa cgccttagcg ggatttgcat
     2281 ttgcaaaaat taattttaca ggtaaaaaaa ttctgtttgg ctttttattg gcattgttaa
     2341 tcattccgat ggaaacagtg ttgattcctc aatttacaat tattaattca cttggcttag
     2401 tcaataatcg tttagcggtt attatccctg gattagctag tgtctttaat atttatcttt
     2461 tccgaaactt ctttattgcc attccagaag aaattatcga atctgcaaaa atagatggtg
     2521 caagtatctt acggatcttt ttcaagatta tgttgcctat gtcgaaaccg gcggttgcaa
     2581 cagttggtgt tctttccttt atttctagtt ggaatgatta tatctggccg ttgatggttt
     2641 taaccgattc gtcaaaattt tcaatgcagg tggcgattac aaccattaat acaactcaac
     2701 cagtttatat caatcaagta atggctgttt tgacaatttc tacgattcca cttattctag
     2761 tatatatcgt agcacaaaaa tatattattc aaggtctagg tggatctggt acaggtatta
     2821 agtaggtgat cagtatgaag gaaagcattc gaaaagcaaa tcagtatatc gatgaaaaca
     2881 gggtaaaggt taaccagcaa tatagaggag catttcattt gctacctcca atcggctgga
     2941 tgaacgatcc aaatggcttt gtttatttcc ttggggaata ccatttgttt taccaattct
     3001 atccctatga tagtgtttgg ggtcccatgc attgggggca tgccaaatca aaagatcttc
     3061 tccattggga agaactgcca gtagctttag cgccaagtga aagctatgat aaggatggct
     3121 gcttctcggg tagtgctatt gtgaaagatg acaagctcta tttgctgtat acgggtcatg
     3181 tagacgatga ggaaaagcga gaagagacgc agtgtcttgc ggtgtcgaca gatggcatta
     3241 cctttgaaaa aatccccact aatccagtga tccatgctca acatattgag gggatcgcag
     3301 atattgcaga ttttcgtgat cctaaagtat ttgaatacca aggaaactat tacgctgtcg
     3361 ttgcttctaa gacaccggat gacagaggtc aaattctcct atttgcctca agtaatctag
     3421 tagattggac ctttacatca gtccttctag aaggtgaaaa agggcaaggg attatgtggg
     3481 agtgtcctga tttcttccct ttagatggca aatgggtctt gatcctgtct cccattgaaa
     3541 tggaaaggca gcaagaaaaa tactggaatt taaattcgac ggttgccttt atcggtgaca
     3601 tgaattggga aacggggcgc tttcatgtcg attcctatga tgaaatagat ggtgggttgg
     3661 atttctatgc tcctcaaact tgtcaaggac caaatggcga acgatacatg gttgcctgga
     3721 tgcaaatgtg gcaccgttcc atccctagtc atgatttagc tcataggtgg gcaggtagta
     3781 tgactcttcc aagaaaattg tccttgaaag acggacgatt ggttcaggag ttacctgagt
     3841 cagtgaaaga acactttctt gtaaagcatt ttccagaaac cattgttaag ggaaatcaga
     3901 tcacgatccc agctagagag aaacaaacct tgtttgaact agatgccaaa ccgggtcgct
     3961 cctttatcct tggatatggt gatgaaactg atcctgattg tgtcttgcaa ttgatttacg
     4021 acgcctctca aaaacgcttt agcttgagtc gagaccaatt tgggcacccc atttctggaa
     4081 aagaagatcc agcatttcaa tcgagatgga ttcagttgga tgctgaaaag gatcatcatt
     4141 tttcaatcat tcgcgatacc aactccatcg aagtattcgt ggatggtaaa actctctcga
     4201 tgacttttta tgaaacgagt caaaatcccg tctataccct cacggcagat gaaggggttg
     4261 attgggtcgt gaaaacctat caaaaatagg atacaaaagc ctcctaaaga aaaaaagaca
     4321 agttctatga cttgtctttt tttctttacg agaggacaga agcgaggagt cctcccagaa
     4381 tgaggatgat agccccgctc agtcggttgg ccatttgggc gaaggcgatc atttccatac
     4441 gatcagatgc ggagagaaca gcgatatttc cggttcctcc catcgagtta ttgatcatac
     4501 cagatccgat agcagtctcc actggataca atccaaccag ttttccgatc acagcagatg
     4561 caagccccat agctagaaca gatgtcaagc ttaggagaat gaattgccag gtcatcgcct
     4621 tagcgagagt tgaaaggtca atcaaggaaa gaccgatccc agctaggact gcatgggtaa
     4681 ggttggtcat aatgacttgg ttgaacatga ccacacagtt ttccaaaggt tttgggacag
     4741 cattgaaagc tttcaggata aagacgatga taatcatgaa ggcataactg tggatttttg
     4801 gaacaaaggc attgcagatg accccgagaa gaaaaatact aaaggcaaac atcattccaa
     4861 ctccgatttg ggtcggatca agggtgagtt tttctttttt caattcatct ttattgacgg
     4921 gaattaagac accgtgacca ttgtagggac tatctgcaaa tactttgacg atcaaaacag
     4981 caccaataat ggcaaggata ttaccaagtg tagtagcggg tgccaattga gagaagatgg
     5041 ctgcttggct tccgtggaga ttggcagcgt agatctttga aagaggcagg attccagctc
     5101 ccattcctcc gaccatttgt gggaaggaaa catagagaat cgaatgtcca aatccttgtc
     5161 ccaaaaggct tccaacgatc ccaaccgaga gagccccaat gaccatggtg accaaggaaa
     5221 caggaataaa gcgagcggaa gcttttacca agagatttcg attcatccct agaatagccc
     5281 cacaaatcaa ggctgcgata taaaaatcaa gaaagccaaa ggaatctccc aaaaagccct
     5341 tggtggctgt gataatgttt gctggaataa catggaaggt cgctagaaga gtagctccaa
     5401 gtagggtgaa gacggatccc ccacctaggt aagaattcat gattggaagt ttttcaccga
     5461 taaagtagag aaagtgcccc atgacgacca aaaggagggt taatccaagc atattgagtg
     5521 ggagtttccc catagcaatc gtcaccgcga gaacgatgac gatgaatgcg tatagaggaa
     5581 gactgacacc ggaaatgttg atttcattca attttttcat ggatgttcag tcagctcctt
     5641 attagtattt aggataccat ttaaggtcac gtacagcttt ggccatatct gtttctttag
     5701 cttgtgcaag cccttgttct tgagctttct tggcaacagc ttcagctacc ttgatagata
     5761 cgtcagctac atattggaat ggtggaagga ctggcgcacc tggttgccct gaattgacaa
     5821 taccggacaa tgagtgagca gctgccccaa tcatttcatc tgtcaacaat ttggcttcag
     5881 aggccaacat accaagacca agacctgggt agatcaaagc gttattggct tgaccgattt
     5941 catagtccac acctttgtag ctgatggttc ctgaagggac accggtagcg acaaaggctt
     6001 taccgtctga ccattcaatg acttgttggg ctgttgcttc caatttcttg gttgggttag
     6061 aaattgggaa gatcactggg cgttcagtgt tttcacacat ggcttcaacc acttctttag
     6121 tgaaggcacc tgggtttgta gaagttccga ccaagattgt tggtttcact gttttgatca
     6181 cttcaagaag attggtcata tcgcctttac cttcgaagtc agcacgtttt ttagcaaatg
     6241 gtttttgagc tggcgtcaaa tcttccatat cgtcaaacaa aagaccttgt ttatcgatca
     6301 tgaagaaacg tttgtaagct tcttctggag aaagtccttc ggcaaccatt tcagcgtgaa
     6361 cacggtctgc gataccagca ccagcagaac caccaccata gcaaaggtaa acttggtctg
     6421 ttaatttttc accagtgata tccatcgctc caaagatacc acccaagaca acgatcccag
     6481 ttccttgaat atcatcgttg aaagttggga tttctttctt gtaacggttc aagatatcag
     6541 ccgcatttga acgaccgaag tcttcccagt gaaggtacaa tttagggaaa agttttccag
     6601 ctgtttgaac aaattgatcg ataaaggcat cgtatttttc accacggaca cgttcatgac
     6661 ggtttccgag atacattgga ttattcaaca attcttcacg gttggtacca gcatcgatga
     6721 caagaggcat aacgcaagct ggatcaattc cggctgctgc agtgtagacc atgagttttc
     6781 caacagagat gtcaacccct tggacacccc agtcaccgat accaaggatt ccttctgcgt
     6841 cagttgcaac aatcaagcgg atatcgcgat cgccagccgc atttttcaat atttcttcga
     6901 tattttctgg gtggttaata tcaaggtaag cggcatattg tgggtctaca aagagttcag
     6961 aatattgttc aatggtgtct gcgatcactg gatcatagac gattgggttg aactcaacga
     7021 tgtgttggtt aaagaggtag tagaaaagag tacggtttgt attgaaaatt tccatcaaga
     7081 aaagacgttt ttcaaggtct gatggtttgc gcaagaaatg ttggtaagct tgttcagctt
     7141 gttcttcgat ggtttgaaca tatggaggaa gaagaccaat caggccaagt tctttacgtt
     7201 cttccattgt gaaagcagtt cctttattta agaaaggatt gtttaaaatt tcatgtgatt
     7261 tcattgcgaa atactcctca taaataattt atctgtaaga ttttttctca cgcaagccat
     7321 tatagtcttc ggtaattctt atagtcaact tcccttgtcc ttataaaaaa attttataag
     7381 taagagtttt gtgttagaat gaaggaaatg gaaattgtag aaatagaggg atagagatga
     7441 atatccgaga cttggaatat ttttatcaac tgtcgaaatt aaagtcttat acagatgtgg
     7501 cgcattattt tcaagtgagt caaccgactg tgacctatgc catcaagcgt ttagaggacc
     7561 actatgcttg tcagttggta gaaaaatctt cttctaatcg tgtcttgcac ctaactcagc
     7621 cggggaaggt tttagccaat cacgcgcgag aagttttaat cgaaatcgaa aagacagaaa
     7681 aagctgttga acgaagtaaa aagaatctgt tgcgcattgg actaccgcca ttgatcacca
     7741 gcgatatcat gaaaaaattt gggacgcatg atgaagagct tgagattttt cgtcaatcgc
     7801 aattggtgca actaggttcc agggatttga tgcgtttgtt ggtgcgtgga gatttagatt
     7861 ttagtctgtt gggaagctta gagcccattt cgcacgcgca tttgaccagt cagctcttgt
     7921 ataaaaaaga attttttgtg attgtttcaa aggatcatcc actagcagat cgcaaggaaa
     7981 tttcttttaa agaggtgtta aaggagacct tcattctgtt agatgagcat catgtccaca
     8041 tgacggcttt taaacacttg aatgctcgct ttgatgattt ggcccagtct actgttgtct
     8101 tgactgattc caacttggtc ttgagtttca tcgaagaaaa tttgggaatt ggtctcatga
     8161 cggatctgac tctctttcca gaatatccaa atcttgtcaa aattccgctg gttgaagagg
     8221 aaaaaacagt cttctatatt agttatgcct atccaaatga aggggaaccc caagcgcttc
     8281 taagctcttt tattgaacgg ttagagaagt gtgaaaaata aggaagctgg tgtcaaacag
     8341 acaaatagaa agtgtcttga ataaaatgag gcttgtagag aaaggaaatt catgatttcg
     8401 ctttgtctgc cagccttttt tggtgttttt tggtataatt aaacttgatc atattctgca
     8461 gaaaggagtt cctatgtcca actatttatc cgtatcaagt ttgaccaaat atttgaaatt
     8521 aaaatttgat aaggatccct atttggaaag ggtttatctg acagggcagg tctccaattt
     8581 ccgaaaacgt cccaaccacc agtatttttc attaaaagat gaaaaagcgg tcattcaggc
     8641 aacggtctgg gctggagttt atcgaagctt tggttttgag ctagaagaag gcatgaagat
     8701 caatgtcatc ggtcgcattc agctctatga gccaagtggg agttattcca ttgtcattga
     8761 aaaggctgag ccagatgggg taggggcctt ggccatccaa tttgagcaac tcaagaaaaa
     8821 gttgactgaa gaagggctct ttcaggaccg gtggaagcaa gctctgccac aatttccaag
     8881 aaagatcggg gtcatcacca gtcaaagtgg ggccgtgatt cgcgatatta tcacaacggt
     8941 gagccgacgc tttcctagtg tagagattgt gctctacccg accaaggttc agggtgaagg
     9001 cgcatctagt gaggtggttg ctaatattca aagggccaac caacgggatg atttggatgt
     9061 tttgattatc ggtcgtgggg gtggttcgat tgaagatctc tgggccttta atgaagaagc
     9121 agtggtgcga gccatctttg aatcgcggat tccgattatc tccagtgttg gacatgagac
     9181 agatacgact ctggccgatt ttgtagcaga ccgacgagcc gctactccga cagccgctgc
     9241 tgaattggcc actccagtaa cgaagttgga tctcttgtcc catttgcaaa agcaggaaaa
     9301 tcgcatggca acagcgatgt ccaatcgctt ggcctataat cgtgaacgtt tggccaaatt
     9361 aagtcaatcg gttattttta gacagcctga aagactctat gatggctacc tacaaaagat
     9421 tgaccagttg caattgcgtt tgaaacaagg aatgcgtgat gcttatggac aaggggccaa
     9481 tcaactgcaa ggtctgcgtc atcgcctaga agccatgtct cctttgcatc gcatcgagcg
     9541 ctaccaagat cgcctgctcc aagataagag aatcttaacc aaccgaatgg aacaagtcct
     9601 aaaagagcaa aagatcaagg tgcaaggctt atcagaagct ctcttgatgc tcgataccag
     9661 tcggattatt gcgcgtggct atgccatggt taagcaagac gatcaggtcc tagactcggt
     9721 tgcgaaagta aaagaagggg acccgctatc actcatcatg agagatggcc agttagaagt
     9781 agaggtaaaa catgtcgaaa gaaaagaaat ttgaagaaaa tttagcagat ttggaagcca
     9841 tcgtccaaaa attggaaagt ggtgatgtgg ctcttgaaga agccattaca gaattccaaa
     9901 aaggaatgaa gttgtcaaaa gaattgcaag ataccttgga tcaagcagag aaaaccttgg
     9961 tcaaggtcat gcaggcagat ggtactgaag cggatctagc atgagacaag aagaaaaacg
    10021 aaatagagta gagcaagcag ttcgctcttt ttatgaggag aaagccgttg ccctccattt
    10081 agtggagtcg gtcctgtatt cggtccaggc aggtggaaaa cgcctgcgcc ccttgctcct
    10141 tctagaattg ttagaggcct ttggacagga attgacggag gctcactttc aagtagcagg
    10201 ggctttggag atgatccata caggaagtct cattcacgat gatctgccag ccatggacaa
    10261 tgacgattac cgtcgagggc aattgaccaa ccacaagaaa tttggagaag acttggcgat
    10321 tttagcagga gatgcgcttt ttctcgatcc ctttgggctg atagctgcca gtgcccttcc
    10381 tgatgcggtc aaggtctcct tgatcctcga attgtcggat gcttccggta gtcgtggaat
    10441 ggtagctggc caagtccttg atatggaagg ggagcacaaa cagctcacgt tagcagaatt
    10501 gcagaccatc catgccaata agacaggacg cctccttgcc tatcctttca tcgcagctgg
    10561 tttgatttta gagttgcaag cagacattgc tcagctctta gaaaaaatcg ggaaaaaatt
    10621 aggcctggct tttcaagtgc gggatgatat tttggatttg gtcgctgatt ttgaagcttt
    10681 ggggaagact cctcaaaagg acttagtagc tgaaaaatcg acctatccag ccctgttagg
    10741 attggaagaa tcaaaagctt tgctgacaag cgaattagat gcttgcgagg acttgttgga
    10801 tcagattaca gctgcttgcg actttgatcc gcgagcgatc aagaaattaa tagaaggatt
    10861 acgaatagat ggctaaggaa agagtggatg tattagccta taaacaaggc ctatttgata
    10921 cccgcgaaca agctaaaaga ggggtgatgg caggtcttgt cgttgccgtt atcaatggtg
    10981 agcgcttcga taaaccgggt gaaaaaattg atgaagcaac cgagttgaaa ttaaagggtg
    11041 aaaagctcaa atatgtcagc cggggcggtc ttaaattaga aaaagccctg aaccaatttg
    11101 gtttatctgt agagggtaaa attgccattg atatcggggc ttctacaggt ggctttacag
    11161 atgtcatgct gcaaaacgga gccagccagg tcttttcggt ggatgtcggg accaatcagt
    11221 tggcctggaa attgcgcaat gatcctcgag tggtctcgat ggaacagttc aatttccgct
    11281 atgccgagcc agatgatttt gaagcgacac cgagctttgc gagtatcgat gtcagcttta
    11341 tttccttgga cttgattctg ccagcccttc accggatttt ggcagaaaat ggacaagtcg
    11401 tggccttggt caaacctcag tttgaggcag gacgcgaaca gatcgggaaa aatgggatca
    11461 ttaaggatcc taagattcat ttagctgtcc ttgaaaaggt cgctgcattt gcagggatac
    11521 atggctttgc ggtaatggga gtggattatt cccctatcca aggaggccat ggcaacatcg
    11581 aatttttgat gtatctagaa aaaaaagaag agaaaacaaa gccaacttca gagcagctgg
    11641 aggctgttgt ggagctggca cacaaggaat ttaaacatga agagtaagaa tatcagatta
    11701 gaaaaaattc gccgcttcat tcgcgatcat gaagtgggga cccaagaaga gatcgtcgaa
    11761 catttgaaag aagaaggcat ctcagcaacc caagcgacag tatcacggga tatcaaagaa
    11821 ttgggcatcg taaaacgtcc tctgaaagac atgacctatg tctatgaatt gccacgcaag
    11881 catcaccaag ggattgggat gattgaaagc aatatcttgt ctcatcgtcg gatgggagaa
    11941 tatgtcaatt tcaccatggt tccagggacg gctcctctag tcaaacgtcg cttgcgggag
    12001 atttataagg agcatatctt tagtattgtt gcagatgatg acacgatctt actgatcgcc
    12061 tattcagctc cagaagcaga gaatatcctc aaatcaatct ttgggtggta agagcctatg
    12121 ctattagaaa tttcgattaa gaactttgcc attatcgaag agatttcctt aaattttgaa
    12181 aagggaatga cggtactgac aggggaaaca ggtgcaggga aatccatcat tatcgatgct
    12241 atgaacatga tgctgggaag ccgtgcaacg acggatgtca ttcgacacgg agccccaaaa
    12301 gcggaaatcg aaggtctctt caccgttgag agcaatcgcc acttgacggc tctctttgaa
    12361 gaacaaggac tagagtggac cgatgaattg atcatccgcc gagagatcct gcaaaatgga
    12421 cgaagtgtca gccggatcaa tggtcaaatg gtgaatttgt ctgtcttaaa ggcagtcggc
    12481 caacatttgg tggacatcca tggccagcat gatcaggaag aactcatgcg cccccaattg
    12541 catatcgcca tgttggatga atttggagat accgcctttt tccaaaccaa agacgcttat
    12601 cgtcagacct tcgaagacta caaacgcctg cgcaaacaag tggtggaact ccagcgcaac
    12661 cagcaggaaa acaaggcccg tattgagatg ttggagtttc agattgcaga gattgaggca
    12721 gctgccttgg aagtggatga ggacctgcgt ctggagcaag aacgccaacg cctgctcaat
    12781 cacaagatga ttgcagatac cctaaccaat gcctatacta tgctggatgc agaagacttt
    12841 tcgagcctct ccaatgttcg ctcagccatg aatgatctgg aaagcatcga agaatatgat
    12901 cccagctaca aagagctctc aagccaatta tcggaaacct tctatgccct tgaggatatt
    12961 accaagcgct tagaagatgt ggttgatggt ctggagtttg acggtaatcg cctcatgcag
    13021 gtggaatcgc gtttggattt gattcactct atcacgcgca agtatggtgg ccaagtcaag
    13081 gacgtcttgg aatacctggc gcaaatcacc aaagaatata gcctcctcac cggaagtgac
    13141 ctctcgtctg aggacttgga aaaagagctc aaacgtttgg aaaagaattt ggtcaccttg
    13201 gctcaagatt tgagtgatca gcggcatgct ttggcccaag ctttggaaaa tgaaatccag
    13261 caagaattgg cagacctcta catggacaag gcgcgttttc aagtacgttt tagcaaggct
    13321 aagtttaatc gtgagggaaa tgaagctgtc gaattttaca tttcgaccaa cccaggtgag
    13381 gactttaaac cccttgtcaa ggtagcatct ggcggagaat tgtcacgctt gatgttggcc
    13441 attaaatctg ctttttctcg aaaagaagga aaaaccagta tcgtctttga cgaggtggat
    13501 acaggagtct ctgggcgcgt ggcccaagcc atcgcagcga aaattcataa gattggtcaa
    13561 aatggccagg tgcttgccat ttctcacctg cctcaagtca tcgctgcagc ggattatcaa
    13621 ttctatattg agaaaatcag tgatgaacac tcaaccgtat ctacagtgcg cttgctcaat
    13681 agagaagaac gaatcgaaga gattgccaag atgctcgcag gagaggatct aacggaggct
    13741 gcccgtcaac aggcagagca acttctcaag cgttaagaga aagaaggttt gaaacaatgt
    13801 caacatactt tgtagtcgga gatattcacg gaaaagccca aatgctagaa gagctcatga
    13861 cagagtggga tggaaaagct caattagtct ttttagggga tttgatagat cgaggtgaaa
    13921 acagcaaacg atcaattgaa atcgtaaaag actacgtaga ccaccacgga gctgtttgcc
    13981 tttctgggaa tcacgagtac atgtttttag cttggttgga caatccagaa gagcgttacg
    14041 atcactaccg aagaaatggt ggcgatacga ccatcaactc tctgttaggt cggccgctcg
    14101 atgctcctgt agatgggatt gcggatgcgc aagccgtaga gaatgccgtc cctgacttgg
    14161 tggccttcat ccgcagtttg ccctttgact atgagacaga aacctattac tttgtccatg
    14221 ccggtgtgga tctaaccctt gaaaattggc gagaaaccag tgattaccaa aaagtttgga
    14281 tccgaaaacc attccatgaa gcggagaatc atacaggcaa atggatcgtc tttggacata
    14341 caccagtcta tggactgctc aatgagccgg tcggtactga aaatctttgg atttcagatc
    14401 agaaaatggg tgtcgatgga ggcgcagtct atggtggagt cctccatgga ttgctcttgg
    14461 atgatcacgg cattgtccat gaccatgtcc ttcacaatac aggtttttct gctgcagacg
    14521 actgaggaag caggaatgga tatctttcac tgcaaaaccc tgtgtttttt gatataatga
    14581 aagcagaaca ttcttaggaa gagtatagaa atatatggca aatattaaaa tagttacaga
    14641 ctcatctatt acaattgagc ctgaagtggt tgaagaatat ggcattacca ttgtgccact
    14701 ttctgttatg gtagatggag tcctttattc cgacagtgag ttgggtgaag gggacttctt
    14761 gcgcttaatg cagtctagca aaaatcttcc aaagactagc caaccacccg ttggagtctt
    14821 tgcggaggtg tatgaaaagt tagcagcaga cggagctcat atcgtttcaa ttcatatgtc
    14881 tcatgccttg tcaggaaccg tagaggcagc tcgtcaaggg gcaaccttgt caggggcaga
    14941 agtaactgtg attgatagtg gctttacaga ccaagctatg aagttccaag tggttgaggc
    15001 agctaagttg gctaaagaag gagcagatct agacaccgtt ttagctcgta ttgaagaagt
    15061 caaagaaaag acagagttgt atatcggcgt atctaccttg gaaaatctag ttaaaggtgg
    15121 tcggattggc cgtgttaccg gacttttgag ctcgcttctc aatatccgtg tggtgatgga
    15181 aatgaaggac catcaattag aaccaatcgt caagggacgt ggaaacaaga cctttaagaa
    15241 atggttggat gagctggtag agaaactatc ccacagcaag gtggctgaga tcgggatttc
    15301 ttacgcaggg acaccagaat gggccaatga aatgaaggct cagttgcaat cgctcgttga
    15361 aaaagcaatc cctgttctcg aaactggatc gattattcaa acccatacag gtgagaatgc
    15421 atttgcagtt ttggtgcgct acgaataagc tgaataaatg tttgaaaaaa caggtttagt
    15481 acttgaccta aaggcttttt ttagatatta tagtactgtt aaggcgtaaa gcctaaaaaa
    15541 atttggagga tttgttaaat ggctaacaaa caagatttga tcgcaaaagt ggcagaagct
    15601 acagaattga ctaaaaaaga ttcagcagca gctgttgacg ctgtattcgc agcagtttca
    15661 gaataccttt caaaaggtga aaaagttcaa ttgatcggtt tcggtaactt cgaagttcgt
    15721 gaacgtgcag ctcgtaaagg tcgcaaccca caaactggta aagaaatcaa aatcgcagct
    15781 tctaaagttc cagcattcaa agctggtaaa gctcttaaag aagcagttaa ataattgcat
    15841 tttgaaaagc catcctagat ttctaggatg gtttttttgt tggacagctc tataggataa
    15901 gggtataata ggaaaaaaga aggagagaga aaagaccatg cgattcattt taggcctctt
    15961 tgccttgttg tttatccgac ctattttgta tctattgaaa gggctgtggt tcgtactgga
    16021 attttgcttt atgatcctcg tggtcaaaat gatcctagga accgtgcgct ggatgaccag
    16081 ttggatcggt tgagagtaga tgaatctatt tcaggctcgt gaatcaatgt cccccggaca
    16141 taaactcgct tttcggtttt caggctcatg aaaaaaatgt ccactggaca tttttttaat
    16201 taaaagcatt ctaaatagtg atttattttg aaacatgcta taataggggt aacgaatcga
    16261 ttaaatcata ttggaaaggg gggatcatag tgaacgcatt gcatcgtcat gaagaagagc
    16321 gcgtggaaga agtcttgcaa aatttgcgtg ccaagggtat tcggattact gatacccgca
    16381 gagcagttct ttcctattta gtggcgagtc atgaacatcc aagcgctgag aagatctatc
    16441 gcgatttatt gcctcagttt ccaagcatga gtctagcaac tgtctacaac aatatcaagg
    16501 ttttgattga tgagggggtt gtttctgaga tcaaggttcg caatgatacc acgacctatt
    16561 ttgatttcat ggggcatgac catttgaatg tggtgtgtga aaaatgtggt cgtatcgcag
    16621 atgtggatat cgaagtccca gatcttcgtg aagaagcagc cagtcaaagt ggctaccaga
    16681 tcaccaaaac ccagatgacg gtctatggca tttgccccga ctgtcagaaa aattaatgtg
    16741 agagaaacca gagccgtcag gctctttttt gatgcaatga gaatatacct atattttaac
    16801 taggagaaaa atagggaaaa tcatgatata atatactttc acgatcaaac aaaaggagaa
    16861 cgagatgaaa aagctagaga atttttcttg gaaaatgtgg cacgtttata ccttgattgc
    16921 tgtggctgta ttttttattg gtagcctttg ttcattcttt tacgtaaaag atgcagacta
    16981 tattgttcat gagcgaaatt atatttatgt tggaaaaggg caacggttga cgaactatga
    17041 aaaagtaaag ggactagata caggattccc aattttagct ctttcattaa aaaatacaga
    17101 tgaagatggt tatgatgatc aaattgctgt cggacataac tatatagcct ttcaagattc
    17161 taagctgggt aatgttaatc aaaatgaaaa agattcggaa gaatatttta aaattcgtta
    17221 ttatctgatt ggagaagaaa aaggagaggg gcataccatt gatgtcttta aaattattca
    17281 gaaactgggt tataaaacga tttatggaaa catggagtca accatgtact ctgatgggaa
    17341 ggacgagtat gtcagggtga aagtgacaga taaggaatcc atctatttta atcttaggac
    17401 gcaaaaggag agtaaaaaac gtccgaagaa aacgatacaa tatggttata aaggcatcta
    17461 tagggccctg tctaatccag atttcattac gaagaacttc gatgaagagg aaagcaacac
    17521 gaaaatttct tggccatggg ttcactataa acagccaaag aagaaaatga ctaccacaaa
    17581 cgatagtagt tattcaactt cagacagtag tgaagaaaaa cctgaagata gcaaacttct
    17641 ttcaatatta aaaaaatatg gatttctcct tgttttagaa gaagacagaa atttatctag
    17701 tagccagtca ttagtgtcga agctatttcc ggatgcaact cactttgttt ggtttattga
    17761 tgatgactat acaagggatg gtcataacga atatatccac aatattgagg aattaatcca
    17821 agtagttgat gaagagaaag ttgagaaagt atatggaaat gaagaatgaa aaactaaaaa
    17881 gctgtctcgt tctagttggc tttttggctc ttatcagtat ttgtttttat agaaatttgg
    17941 aaacaaacat caaaggactc tataaaagca atcattatcc aggtgagata aagatcacca
    18001 gtctttccct atctactcaa gataaattgg gaatagatgt caattatgtt tattctgaga
    18061 aggtcaatgg aaaagtcatt tctattccat taaagagacg aatgaaggtt gaacaatttg
    18121 ttattccata ttatccttat ttgggtaaag aaggtcgtta tggaatgact ggggattcga
    18181 ttggaatgta tgctgaggag tatagtgtat atggtccaat tcttgaaaaa gcactcgagc
    18241 tcaatcctga cagtaagaaa ttggaacagg aaattcaaaa taaaatcaat caaaactcta
    18301 cgttaaaagg ctctaaaatc actttgaaat ttacaacttt cagtcaatta tcaaattatt
    18361 atagagttag atggctcggt gaatatgaga aagaatcaat gaagaagaat cgtaccgtac
    18421 ttggaggctg gtatcaattt ccagtagagg atgcattaga atataatgcc ttgtatgttc
    18481 aaatttcgct accaaaaggt gtcgataaag aaagtataca tctgaaggat gagttgaata
    18541 cacttttaca aaaaacgagc ttaccaaatg ggatttatgc tcttgatacc tcaactgaac
    18601 tacccacagc tcgagctatg atttttaatg gaaaggttaa agaaagggat taaacatgtc
    18661 agaaatacaa aaggatactg gacttagtct agcttgggaa cttggattgt atattttcct
    18721 aattttttca tttctagctt tgccatttta caatgatcta gctatttcaa atccaaataa
    18781 ttcacaaatt tttctctttc tggacaataa ccctgtgttt gggggtgaag cgtttgagga
    18841 tcttgtaaat ttttatttta tcattttact tttactatta gtaaccttac ctatccttgc
    18901 ttttttcatt cataatttct ttgaaaaaaa gggataccca tttttagcta gtttacagtc
    18961 tttgttgatt catgtatctt gtgtagtaat gttcgtttat gcggtgtttt ctttgtcagt
    19021 tcagaaagat cactatagct ttagctcagg tttctatgtc tgcttactca tttatttgtt
    19081 tcatatttat agcaacttac gtgatataaa aaagatgatt gaatatcgaa attctgctac
    19141 caaaacagct aatgaggcag aaatcttatc aaaagaatag ttctatattg tgaatgtttg
    19201 ttgaagacaa aaagaagcaa gctattttca aaccagagcc gtcaggctct tttttgtatg
    19261 gtaaaaccac actaggatag tgaaggaaaa ataggagaaa tcatgatata atatactttt
    19321 gaaatcaaac aataggagaa cgagatgaag aagctggaga atttttcttg gaaaatatgg
    19381 catattcttt ccctagttgc cgtgaccgtt ctaatggttg gcggtatttg gagcttcctt
    19441 tacctaaaag aagcagtaca tgttgtgagt gatagaaatt atgattatgt tggtagagga
    19501 caacggttat tggaaaatcg aatcattagt gaagaggcca ccggaattcc aatattggct
    19561 tatagtttta agaaagaaga taaaaataat gccccatatt atactatcgg atcccaatat
    19621 atagcccttc aagattctaa actaatcagt ggcgaagata agaaaaaaga cgcaaatgaa
    19681 tattttagaa ttcgatatta tgaattgggt caagagaaag gagaaggtca taccattgat
    19741 gttttaaaac tcgttcaaaa aatgggttac gactcgattg aaggaaacat gcgaagtagc
    19801 atgtttacag atggaaaaga tgagtatgta gctttcaatg ttacaaaaaa taatctccta
    19861 tttgtgaatc tgaacaaggg agaaatcgca gagacagatc caaaaatgat tgttgattat
    19921 ggttacagtg gattttatca aatattgcct gcacccaaat ttgagacaaa aaaatacagt
    19981 cttgatagaa ataaaataga tgtaggagga tgttggatag attatgaata tgatgatgaa
    20041 gatgaaaaag tagaaacttc ctcaagttct acggagagat tagatcgcaa tggtgtgaag
    20101 gtgaaggata gtaaactctt aaccctacta aaaaaatatc gccatctctt gattttaaaa
    20161 caaaacctca ctatggagga ggaaaaaact gtcatcaaga gtttgtttcc tgatgcagat
    20221 catttcagtt ggtctattag cgctccttat acaaagagtg ggcagaaaga aatcgttcgg
    20281 aatgctgaag aatttaaaaa gattataaag gaggaaagag ttgaagaaga gttggaacgt
    20341 gaatttgaaa aaacatttca agaagggcca gacgacgatt agtgatcggt caaaagcctt
    20401 tctagtggtt atctgcttcc tactgtttct aggattctat ttttatagaa atttagacgc
    20461 taacctaaaa ggtttctatg atagtagaag tttccgggga gatatacaga ttacaggttt
    20521 ctcttggact cgtcccaatg ccggtccgga tgtgaatttt atctattctg aaacggttga
    20581 agggaaaaag atttccattc ctttgaaaaa atcagtcaga tttaaacact tggtgatgcc
    20641 gtattctaat aagattgatt tagctgaaaa cctaggaata gaaaatacct atgatgattt
    20701 tgatagagcc tatttgccta ttatagagaa gggatttgaa ttcagtactg agcgaatcga
    20761 gcttgaagca gaattagata aaaaaatgaa cgagtatagt gcttttagcg gctcttggat
    20821 tgaaataagc ttatcccccg ttaagaaacg aggtaacaat tatttcagtt tgatgg
//
