LOCUS       NZ_CP011509            11650 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Archangium gephyra strain DSM 2261 chromosome, complete genome.
ACCESSION   NZ_CP011509
VERSION     NZ_CP011509.1
KEYWORDS    RefSeq.
SOURCE      Archangium gephyra
  ORGANISM  Archangium gephyra
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Archangium.
REFERENCE   1  (bases 1 to 12489432)
  AUTHORS   Sharma,G. and Subramanian,S.
  TITLE     Genome assembly of Archangium gephyra DSM 2261
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12489432)
  AUTHORS   Sharma,G. and Subramanian,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2015) Protein Science and Engineering, Institute
            of Microbial Technology, Sec-39 A, Chandigarh, Chandigarh 160036,
            India
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: HGAP Pipeline v. SMRT v2.3.0
            Coverage                          :: 79.3
            Sequencing Technology             :: PacBio
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001027285.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:37:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,001
            CDSs (total)                      :: 9,898
            Genes (coding)                    :: 9,822
            CDSs (with protein)               :: 9,822
            Genes (RNA)                       :: 103
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 28 of 76
            Pseudo Genes (incomplete)         :: 45 of 76
            Pseudo Genes (internal stop)      :: 6 of 76
            Pseudo Genes (multiple problems)  :: 3 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7604382
            Orig. end                         :: 7616032
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11650
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="35"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11650
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11650
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6650](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6650)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(838..852)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.3"
                     /tool="antismash"
     gene            complement(1210..2115)
                     /locus_tag="AA314_RS29660"
                     /old_locus_tag="AA314_06058"
     CDS             complement(1210..2115)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002626175.1"
                     /locus_tag="AA314_RS29660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06058"
                     /product="hypothetical protein"
                     /protein_id="WP_047858259.1"
                     /transl_table=11
                     /translation="MKRYFGVIVIIAGILIGGVMTYRASSAKALAAQREAEFTRIQSAY
                     LERVGWMRTNPDEASYRQELAPFFKTYFEQIGEHQSRFKLSKDFDAYLVELEKRGEKED
                     RAADRKAYYEYTRKVFDQMREGRYKPEWTATDKGMRLDVVSSDVVKVLNKPQVRLQLAL
                     WGAHREERTDGKVKKMVTSAAFKTQWKLTDERGKLIGEMTGDDPSMKVDYPERFIAEFP
                     PQMVLGHYDMDLVPSEVKKMEITFNVSSRAVSGGDVTATYVWKLDVPSDWRLGAGEQWE
                     GAEVTERAEDEIDPSKAQKK"
     gene            2174..3172
                     /locus_tag="AA314_RS29665"
                     /old_locus_tag="AA314_06059"
     CDS             2174..3172
                     /NRPS_PKS="Domain: Abhydrolase_1 (75-313). E-value:
                     9.2e-11. Score: 33.7. Matches aSDomain:
                     nrpspksdomains_AA314_RS29665_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002626177.1"
                     /locus_tag="AA314_RS29665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06059"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_047858260.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-09, bitscore: 37.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQTTGSVALPVALPLEEGGLLGGAQLAWSAYGERSDDNVAVLLH
                     DLPHSHRALGPVEQAAFQPSGWGTELVGEGRPLDTSTLHVVVPNLLGSPFGSTSPVTVD
                     ARAGLPYGAALPTVTVTDMARAVAAMLRGMKVRHVRALVGVGLGGLVALRLAALFPELP
                     AAVVVLGAARTLPEAQRERLGLARHLLRLDPDFHEGQYTPGHGPKRTLRKQYLEYLRLV
                     HGPAEPALEAEADAFAEGFDANTWALLCTAYAGGDVTDSLAQVRAPVLLVAAAEDALAP
                     PSRVRDTYHLLSAAGVRAHYHELPAPSAHASLLTQVRRLHGPMRDFLRRRS"
     misc_feature    2201..2203
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        2399..3112
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AA314_RS29665_Abhydrolase_1.1"
                     /evalue="9.20E-11"
                     /label="AA314_RS29665_Abhydrolase_1.1"
                     /locus_tag="AA314_RS29665"
                     /protein_end="313"
                     /protein_start="75"
                     /score="33.7"
                     /tool="antismash"
                     /translation="RPLDTSTLHVVVPNLLGSPFGSTSPVTVDARAGLPYGAALPTVTV
                     TDMARAVAAMLRGMKVRHVRALVGVGLGGLVALRLAALFPELPAAVVVLGAARTLPEAQ
                     RERLGLARHLLRLDPDFHEGQYTPGHGPKRTLRKQYLEYLRLVHGPAEPALEAEADAFA
                     EGFDANTWALLCTAYAGGDVTDSLAQVRAPVLLVAAAEDALAPPSRVRDTYHLLSAAGV
                     RAHYHELPAPSAHASL"
     gene            complement(3177..3812)
                     /gene="udk"
                     /locus_tag="AA314_RS29670"
                     /old_locus_tag="AA314_06060"
     CDS             complement(3177..3812)
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002626178.1"
                     /locus_tag="AA314_RS29670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06060"
                     /product="uridine kinase"
                     /protein_id="WP_047858261.1"
                     /transl_table=11
                     /translation="MSSPLVVGIAGGTASGKTTVARKVRDALADCRVAFIDQDSYYRDL
                     SDLTLAERREVNFDHPDAFDTDLLVEHLRELKAGRPIHKPVYDFVTSTRQKHTVRVDPG
                     DMILIEGILVLHMKPVRDEMNVRIYVDTDDDLRILRRLERDIHERGRDFDHVVSQYLRH
                     VRPMHMGFVEPSKHHADIIVPHGGNNDIAIGMLVGALRGRLVNPHLQR"
     misc_feature    complement(3967..3981)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.73"
                     /tool="antismash"
     misc_feature    complement(3984..3999)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.17"
                     /tool="antismash"
     gene            4050..4985
                     /locus_tag="AA314_RS29675"
                     /old_locus_tag="AA314_06061"
     CDS             4050..4985
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002626179.1"
                     /locus_tag="AA314_RS29675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06061"
                     /product="hypothetical protein"
                     /protein_id="WP_047858262.1"
                     /transl_table=11
                     /translation="MQTGVFAGGVRRLGLVVLLLAASGCEPLETAPEPLARRTHAVKDL
                     NTGNGLSLNGLSLNGLSLNGLSLNGLSLQGLATAEFDAWFQLDPELHDAVMKYLVGCAV
                     PSGESRTYTSPTTGRSWSWTGALGLAPDWSNGRPATLAEQRIISACLAAHVDKYELHIS
                     ISVQGLSATGVAIPTPDWELLLYSEKEACFFGNLFNAEGIYAGNDGRPLTDRESTARTC
                     ALSCRRDLNTQPCAPLLRVEQDCARFCTLDAARRFYVSCSYNGISYPAITTRMLRSDIY
                     MCGDGVCQVTEKCGTGESFDNCGRDCGPCP"
     gene            complement(5001..6650)
                     /locus_tag="AA314_RS29680"
                     /old_locus_tag="AA314_06062"
     CDS             complement(5001..6650)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002626180.1"
                     /locus_tag="AA314_RS29680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06062"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /protein_id="WP_047858263.1"
                     /sec_met_domain="DUF692 (E-value: 4.1e-24, bitscore: 84.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPEAAAWQLPWRGLGLSSNLDAADQPHPYRLLAESPGLFDYVE
                     YSAPLSLDETRRHASLFPEMWERRGEVPVLFHPVHLNLYGPELEPVKALADLDAHARAV
                     GSAWVGNDIGWWHAGGQPFPGYLYFTPPFTEAGVRDSVAHALHVQSHLSVPLALENPAA
                     FAKRGELHVLDFLARVHARTGLPLLIDLGHLLSYQLAAGLPLEAGLDGFPLDKVIELHL
                     AGGVITRRNGRGYYVDDHTQPVREELFGLLESLLPRCPSLRAVTFEGDGHPSEVAALTL
                     RRLRKLVPAAPPRPPLTLTPVKEPAPALTRESEPWSLYDIGYGVKAETGSDIEGARAET
                     DFRLAVVAETLDRDWPVSRLLLAGTREGLRAFTASKEFRELFEGLGRSPGHAFASWARR
                     QLRERPDEGAAAAVTFETFLPNAFMTRPAPAPGPGQVGLAEDVRVGSFPVDLTELVFAA
                     KSLRRHLTGRAWACEVLDVSGLESLAQVARRPAPGPWTFVVRRRGRGLEVLPVPPSLLQ
                     VLCSLVQAPRAVEELPAAVLTEGRALGVLRRG"
     gene            6777..8033
                     /locus_tag="AA314_RS50920"
                     /old_locus_tag="AA314_06063"
     CDS             6777..8033
                     /EC_number="3.4.13.-"
                     /GO_function="GO:0070573 - metallodipeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013413.4"
                     /locus_tag="AA314_RS50920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06063"
                     /product="membrane dipeptidase"
                     /protein_id="WP_082175426.1"
                     /transl_table=11
                     /translation="MSIRGTWLCSWMLLGSLGCAALRTPPEETAPPVAPEVVRADLHVH
                     VTMRAALGPLFQGEPGEGVLAGSHAERFVNQVDAAALRRAGVRLILATVWPPPATRPGR
                     GALGEALHQLAELESFTRRNPDFVLAHGAAEARRKLADGQLVLIPAVEGGEGIRRVEDV
                     DLLYAAGARSITLVHFFDNPLADAADDQFGAAVGGLANGRDGGLTPLGAQAVRRMLQLG
                     ILIDVAHASDRTIEEVLAIAGPAGAPLLYSHTGAGWAATRCLSTPLAQRIAAGGGLIGI
                     GLFRSPFQEVPPSERWEGFQPGTCDDDVAHWLHYARQVGPEAVLLGSDFSSAILRARPG
                     GACPQGLRHTGDLPTLFAALEAHGLSRHTLDNSGERLLRLLETVEGRADPSVLPSARKL
                     PVPRDDLFLERVAPLPRNQ"
     gene            8131..8571
                     /locus_tag="AA314_RS29690"
                     /old_locus_tag="AA314_06064"
     CDS             8131..8571
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AA314_RS29690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AA314_06064"
                     /product="hypothetical protein"
                     /protein_id="WP_047858264.1"
                     /transl_table=11
                     /translation="MLAHSVVNGTKTWTTPNGELRLWQPAPHVIVTRFQGAMYDAHLAH
                     LAMMSIEGIVSTQTKTDVFHDWEEMELYATEARTIMTERAIPLAPKLNSLSVLFGSKVV
                     LMGVSLASLKLGGINTYTSREDFEQAVQQAAASRPGTFKPPH"
     gene            8582..9235
                     /locus_tag="AA314_RS29695"
                     /old_locus_tag="AA314_06065"
     CDS             8582..9235
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.4"
                     /locus_tag="AA314_RS29695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06065"
                     /product="HAD hydrolase-like protein"
                     /protein_id="WP_047858265.1"
                     /sec_met_domain="HAD_2 (E-value: 1.1e-31, bitscore: 109.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITNVVFDFDGTIANSRSVVIAAYNQVAEKHRFNPMVEADIPVLS
                     RLSIPERCRKMGVPLLKLPLVMAEVGRTYKNVMGSVVAFDGMLPVLQTLHRHGLTVGII
                     STNNAENIQRFLARNGMEAVVQRIHCSSNMFGKDKVISRYLKTYGLTPEQVLYVGDEER
                     DVVACRKTKLRVLSVSWGFEVLDVLTKAGPDFIAHQPTDILQRVAELNGLPHLA"
     gene            complement(9295..10131)
                     /locus_tag="AA314_RS29700"
                     /old_locus_tag="AA314_06066"
     CDS             complement(9295..10131)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013935153.1"
                     /locus_tag="AA314_RS29700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06066"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_047858266.1"
                     /transl_table=11
                     /translation="MSTRTDEQLMEAARSGDDKAVDELLARHEKQVYRFGLRMCGSEED
                     AREVLQETLLAAFRGIHAFRGGAALSTWLYQVARTYCFRLRRRRAGAPEEFHPLDSPAA
                     THVAVEEAAPDMAAHARQMGEVLQAAILALPEAWREVLILRDVEGLSAEEAAQVVGIEV
                     RALKSRLHRARLQLREHLSTLMGESAQGQAQGCPELAQQLSEFAVQDVDQATCVRLEDH
                     LSRCPRCAQACDSLKRTVSLCRRIPGDEVPAPVRAAVRQALARALPTGNDRDVKGT"
     misc_feature    10164..10178
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.56"
                     /tool="antismash"
     gene            10324..10752
                     /locus_tag="AA314_RS29705"
                     /old_locus_tag="AA314_06067"
     CDS             10324..10752
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015351999.1"
                     /locus_tag="AA314_RS29705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06067"
                     /product="YeeE/YedE family protein"
                     /protein_id="WP_047862475.1"
                     /transl_table=11
                     /translation="MTGFSLPLMGGVLIGLSASLLLLFNGRVAGISGIVGGLLAPSRGE
                     VPWRLAFIAGLVGGGFLVRALLPGAFGQETSSPAPGLTVAAGLLVGLGTHLSNGCTSGH
                     GVCGVSRGSMRSIVATLVFMATGALAVFVLRTLRGGVL"
     gene            10749..11204
                     /locus_tag="AA314_RS29710"
                     /old_locus_tag="AA314_06068"
     CDS             10749..11204
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013935154.1"
                     /locus_tag="AA314_RS29710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_06068"
                     /product="DUF6691 family protein"
                     /protein_id="WP_047858267.1"
                     /transl_table=11
                     /translation="MKTSLSALLAGLLFALGLGVGGMTDPARVRAFLDVTGNWDASLAF
                     VMAGALGTHALLRRFILRHPKPVFAPAFPTASRTKVDRRLLVGAALFGAGWGLSGYCPG
                     PALTSLASGASTALTFVAAMLGGMLLLRLWESSRISHEAVTSSRGGA"
ORIGIN
        1 gatggcttcc tcggcctcca cggagcgggg ctccttgaga tcgaagacct ccgacgtgag
       61 ccaggcgttg gcatctcccc ggggccgcca gtcagcacgc gtgaccttca cgtcgccacc
      121 gacgaggtcg aacatgaaga gcgcgtcctg ctccggatcg aagtggggct cgacggaggc
      181 caacaacatt ggggcgtgag tgaccgcgag gatctgcacc ttgacgtcgg gacgcagctc
      241 actggccacg gacatcaggg acggcaggat gagccgctgc caccggggat gaaggtgtgc
      301 ctccacttcg tccacgagca gcacgaggga tttggatgtc tcctcccgaa gaagctcggc
      361 ggctcgttgg tgttcctccc aggcccagac gagcaggtag gcgagcccga cgatccgtct
      421 gaccgcggcg gatgcgtggg tgagcggaat ggtgccgtag ggcatctcca gcgtggggat
      481 gtcccgcacg tcgtcgatac cgatgcgcgt gggctctcca ggcgtcaagg gctcctgctc
      541 gtgtgcggag agtacccgga ggacacgccg cagacgctcg aagggctccg acctcttgag
      601 ctgccaggac acccagtcgc gaatgagccc gttacacacg gcgcggccat tccgcgccag
      661 accgtcccag agttcttccc gtgagaactc atactctggc agtggcgtat gcatgccgtg
      721 ctgccagcgc aggtcgttac ggatgggatc ccacacggag aagctcccat ccacacgtgc
      781 atagagggtc aggcctggat tgatggcgaa tccactcgaa tcaaccaggt gcggtggaat
      841 ggtctgaaca acggtatggc gcttgccatc gttcctgacg atcgatgcct cgaccctggc
      901 ccttcccggc caatccttcc tgggcagggc ggggagcggc tcccgctcat gggcggtcag
      961 cgcccaccac gccagatcca gcacgaacgt cttgccgaga ccattgtccc cggtcagcag
     1021 gttgagacgc ggggcgaacg agaacgacat ccgagggctc ggccccactc cctccagctt
     1081 cagcccttcg agcatgccgc gtcctcctca cgcgaggagt agcaccgtag cgcgctgaat
     1141 caaggacaga ggcggcgggt ggcaccccga acaggccgcg gtgccacccg cgcgagcgtc
     1201 ccggccgggc tacttcttct gcgccttgga cggatcgatc tcgtcctcgg cccgctcggt
     1261 gacctcggcg ccctcccact gctcacccgc gcccagccgc caatcggagg gcacgtccag
     1321 cttccacacg taggtggccg tgacatcgcc gcccgacacc gcgcgcgagc tcacgttgaa
     1381 ggtgatctcc atcttcttca cctcgctggg caccagatcc atgtcgtagt ggcccagcac
     1441 catctgcggc gggaactcgg cgatgaagcg ctcgggatag tcgaccttca tcgacggatc
     1501 gtcgcccgtc atctcgccga tgagcttccc ccgctcgtcg gtgagcttcc actgggtctt
     1561 gaacgcggcg ctggtgacca tcttcttcac cttgccgtcc gtgcgctcct cgcggtgcgc
     1621 gccccagagc gccagctgca gccgcacctg cggcttgttg agcaccttca ccacgtccga
     1681 gctcaccacg tccaggcgca tgcccttgtc cgtggccgtc cactccggct tgtaacggcc
     1741 ctcgcgcatc tgatcgaaca ccttgcgcgt gtactcgtag taggccttgc gatccgccgc
     1801 gcggtcctcc ttctcgccgc gcttctcgag ctccaccagg tacgcgtcga agtccttgct
     1861 cagcttgaag cggctctggt gctcgccaat ctgctcgaag tacgtcttga agaagggcgc
     1921 gagctcctgc cggtaggagg cctcgtccgg gttggtgcgc atccagccca cgcgctccag
     1981 gtacgcactc tggatacggg tgaactccgc ctcacgctgg gccgcgagcg ccttggcact
     2041 cgaggcgcgg tacgtcatca ccccgccaat gaggatgccg gcgatgatga cgatgactcc
     2101 gaaataacgc ttcacgcgga gatgctcctg tctctgggaa atgacggccg tagtgatatg
     2161 agacctgcct cgcgtgtacc agaccaccgg cagcgtggcg ttaccggttg cacttcctct
     2221 agaggagggc ggcctgctgg gcggggccca gctcgcctgg tccgcctacg gtgagcgctc
     2281 cgacgacaat gttgccgtgc tgctgcacga tctcccgcac tcgcaccggg cgctggggcc
     2341 cgtggagcag gcggccttcc agccctcggg ctggggcacg gagctcgtcg gcgaggggcg
     2401 gcccctggac acctccacgc tccacgtggt ggtgcccaac ctgctcggca gcccctttgg
     2461 ctcgacatcg ccggtgacgg tggacgcgcg ggcgggcctg ccctacggcg cggcgctgcc
     2521 cacggtgacg gtgacggaca tggcgcgcgc ggtggcggcc atgctccgcg gcatgaaggt
     2581 gcggcacgtg cgggcgctgg tgggcgtggg gctcggaggg ctggtggcgc tgcggctcgc
     2641 ggcgctcttc ccggagctgc cggcggcggt ggtggtgctg ggcgccgcgc gcaccctgcc
     2701 cgaggcccaa cgcgagcggc tcggcctcgc gcgccacctg ctgcggttgg atcccgactt
     2761 ccacgagggc cagtacacgc cgggccacgg gcccaagcgg acgctgcgca agcagtacct
     2821 ggagtacctg cggctggtgc acgggcccgc cgagccggcg ctggaggccg aggcggatgc
     2881 cttcgcggag ggcttcgacg cgaacacgtg ggcgctgctg tgcacggcct acgcgggagg
     2941 agatgtcacc gacagcctgg cgcaggtgcg ggcgccggtg ctgctggtgg cggcggcgga
     3001 ggacgcgctg gctcctccgt cccgggtgcg cgacacgtac cacctgctca gcgcggcggg
     3061 tgtgcgggcg cactaccacg agctgcccgc gccgagcgcg cacgcgagcc tgctcaccca
     3121 ggtccggcgg ctgcacgggc cgatgcggga cttcctgcgc cgccgcagct gagccgctag
     3181 cgctgcaggt ggggattgac cagccggccg cgcagcgcgc ccacgagcat cccgatggcg
     3241 atgtcgttgt tgccaccgtg ggggacgatg atgtccgcgt ggtgcttgga gggctcgacg
     3301 aagcccatgt gcatggggcg cacgtggcgc aggtactggc tcaccacgtg atcgaagtcg
     3361 cgcccgcgct cgtggatgtc gcgctcgagc cgccgcagga tgcgcaggtc gtcgtcggtg
     3421 tccacgtaga tgcgcacgtt catctcgtcg cgcaccggct tcatgtgcag cacgaggatg
     3481 ccctcgatga ggatcatgtc ccccgggtcc acgcgcaccg tgtgcttctg ccgggtggag
     3541 gtgacgaaat cgtagaccgg cttgtggatg ggccggccgg ccttcagctc acgcaggtgc
     3601 tccacgagca ggtccgtgtc gaaggcgtcc gggtggtcga agttgacctc ccggcgctcg
     3661 gccagcgtca ggtccgacag gtcccggtaa tacgagtcct gatcgatgaa ggccacgcgg
     3721 cagtcggcga gtgcatcgcg gaccttccgg gcgaccgtcg tcttgccgga agcggtacca
     3781 ccggcgatgc caacgacgag gggtgacgac atgagccgca actaccgcag cagggtgggc
     3841 acgcgcaaga ctgcgtctgg aaccggacaa ttccggcctc gtgccctctg tcggagcccc
     3901 gacacctctc cctcgtactc gaagtcatca cctttactga tttcagccat aagcgcattc
     3961 ttcaatcgga gcgcatcttc ctcgcgacca cgccttcgag gctccccggg cccaggcccg
     4021 gacccatcgc aaccgttggg gggaagccca tgcaaaccgg tgtcttcgcc ggaggtgtcc
     4081 gtcgactggg gctcgtggtg ctgctgctgg ccgcgagtgg ctgtgaaccg ctggaaacgg
     4141 ctcccgagcc gctcgcccgg cggacccacg cggtcaagga cctgaacacc ggcaatggcc
     4201 tgtcgctcaa cggcctgtcc ctcaatgggc tgtcgctcaa cgggctgtcg ctcaacgggc
     4261 tgtccctcca gggactggcc accgccgagt tcgacgcctg gttccagctg gacccggagc
     4321 tgcacgacgc ggtgatgaag tacctggtcg gctgcgccgt cccgtccggg gagagccgca
     4381 cctatacgtc tcccaccacg ggcaggagct ggagctggac gggggccctg gggctcgcgc
     4441 cggactggag caacggcagg cccgccacgc tggccgagca acgcatcatc tccgcctgcc
     4501 tcgccgccca cgtggacaag tacgagctcc acatctccat ctccgtgcag ggcctgagcg
     4561 ccacgggcgt ggccatcccc accccggact gggagctgct gctctactcg gagaaggagg
     4621 cctgcttctt cggcaacctc ttcaacgccg agggcatcta cgccggcaac gacgggcgcc
     4681 cgctcaccga cagggagagc accgcgcgca cctgcgccct ctcctgcagg agggacttga
     4741 acacccagcc ctgcgccccc ctgctgcgcg tcgagcagga ctgcgcgagg ttctgcaccc
     4801 tggatgccgc gcggcgcttc tacgtgtcct gctcctacaa cggcatcagc tacccggcca
     4861 tcaccacgcg gatgctccgc tcggacatct acatgtgcgg ggatggtgtc tgtcaggtga
     4921 ccgagaagtg cggcacgggc gagtcgttcg acaactgcgg cagggactgc ggcccctgcc
     4981 cttgacccgg cccgtgtggc tcagccccgg cgcaacaccc ccagggccct gccctccgtc
     5041 agcaccgcgg cgggaagctc ctccaccgcc cggggcgcct gcacgagcga gcacagcacc
     5101 tgcaacagcg agggcggcac cgggagcacc tccagtcccc tgcccctgcg ccgcacgacg
     5161 aaggtccatg ggcccggagc cggacgccgg gccacctgcg cgagcgactc gaggccactc
     5221 acgtccagca cctcgcacgc ccacgcccgc cccgtgaggt ggcggcgcag cgacttcgcg
     5281 gcgaagacga gctccgtgag gtccaccggg aaggagccca cgcgcacgtc ctcggcgagc
     5341 cccacctgtc ccgggccggg cgccggcgcg ggccgcgtca tgaaggcgtt gggcaggaac
     5401 gtctcgaagg tgaccgccgc cgcggcgccc tcgtccggac gctcgcgcag ctggcgccgc
     5461 gcccaggacg cgaaggcatg tcccggcgag cggcccaggc cctcgaagag ctcgcggaac
     5521 tccttggagg cggtgaaggc acgcagcccc tcgcgcgtgc ccgcgagcag cagccgcgac
     5581 accggccagt cccgatcgag cgtctccgcc accaccgcga gccggaagtc cgtctccgcc
     5641 cgggccccct ctatgtcgct ccccgtctcc gccttcacgc cgtagccgat gtcatagagg
     5701 gaccacggct cgctctcgcg ggtgagggcc ggcgcgggct ccttcaccgg cgtgagcgtg
     5761 agcggaggcc tcggcggggc ggcgggcacc agcttgcgca ggcggcgcag cgtgagggcg
     5821 gccacctcgg acgggtgtcc gtctccctcg aaggtgacgg cgcgcagcga ggggcagcgc
     5881 ggcaacagcg actccagcag gccgaagagc tcctcgcgca cgggctgggt gtggtcatcc
     5941 acgtagtagc cccgcccgtt gcgccgcgtg atgacaccac cggcgaggtg gagctcgatc
     6001 accttgtcca acgggaagcc gtcgagcccc gcctccaggg gcagcccggc ggcgagctgg
     6061 tagctgagca ggtgtcccag atcgatcagc agcggcaggc cggtgcgcgc gtgcacgcgg
     6121 gccaggaagt ccagcacgtg cagctcgccg cgcttcgcga aggcggcggg gttctccagc
     6181 gcgagcggca cggacaggtg cgactggacg tggagcgcat gggccacgct gtcgcggaca
     6241 ccggcctcgg tgaagggagg ggtgaagtag aggtagcccg ggaagggctg cccgcccgcg
     6301 tgccaccagc cgatgtcgtt gcccacccag gcgctgccca cggcgcgcgc gtgcgcgtcc
     6361 aggtccgcga gtgccttcac cggctccagc tcggggccgt agaggttgag gtgcacgggg
     6421 tggaagagca cgggcacctc gccgcggcgc tcccacatct cggggaagag cgaggcgtgc
     6481 cgccgcgtct cgtcgagcga caggggggcg ctgtactcga cgtagtcgaa gagaccgggc
     6541 gactcggcga gcaaccggta ggggtgcggc tggtccgccg cgtcgaggtt gctgctcagg
     6601 cccagcccgc gccaggggag ctgccaggca gccgcttcag ggtggctcat ggagcgtcaa
     6661 ccctacagcg ggcagcgccc attctcagca ctcccgatgc ccggcggccc ctctccctct
     6721 gggagcacga caatccccct gatgctccgg catgctccgc tcccagaggt gaggcgatga
     6781 gcatccgggg tacgtggctc tgttcgtgga tgttgctggg aagcctgggg tgcgccgccc
     6841 tccggacgcc tccggaggag accgctcccc cggtggcacc cgaggtggtc cgggccgatc
     6901 tccacgtgca cgtgaccatg cgcgcggcgc tcgggcccct cttccagggc gagcccgggg
     6961 agggcgtgct ggcgggctcg cacgcggagc gcttcgtcaa ccaggtggac gcggcggcgc
     7021 tgcggcgcgc gggtgtgcgg ctcatcctcg cgaccgtctg gccgcccccc gccacccgtc
     7081 ccggccgcgg cgcgctgggc gaggccctcc accagctcgc ggagctcgag tccttcaccc
     7141 ggcgcaaccc cgacttcgtg ctggcccacg gtgccgcgga ggcgcggcgg aagctcgcgg
     7201 acggacagct cgtgctcatc cccgccgtcg agggcggtga gggcatccgg cgcgtggagg
     7261 acgtggacct gctctacgcc gcgggagcgc ggtccatcac cctcgtccac ttcttcgaca
     7321 acccgctggc cgacgcggcc gatgaccagt tcggcgcggc ggtgggcggc ctcgccaacg
     7381 gacgggatgg aggcctgacg cccctcggcg cgcaggcggt ccggaggatg ctccagctcg
     7441 gcatcctgat cgacgtggct cacgccagtg atcggaccat cgaggaggtg ctcgccatcg
     7501 ccgggcccgc cggcgcgccg ctcctctact cccataccgg ggccggctgg gccgcgacgc
     7561 gctgcctgag cacgcccctc gcccaacgga tcgccgcggg cggagggctg atcggcatcg
     7621 gcctcttccg ctcccccttc caggaggttc ccccctccga acgctgggag ggcttccagc
     7681 cggggacgtg tgacgacgac gtggcccact ggctgcacta cgcgcgacag gtgggccccg
     7741 aggccgtcct gctcggcagc gacttcagca gcgccatcct ccgcgcccgg ccaggaggcg
     7801 cctgtcccca aggcctccgc catacggggg acctgcccac cttgttcgcc gccctcgagg
     7861 cccatggcct ctcccgccac accctggaca actccggcga gcggctgctg cgcctgctcg
     7921 aaacggtgga gggccgggcg gatccctccg tccttccgtc cgctcgcaaa ctccccgtgc
     7981 cacgggacga ccttttcctc gagcgggtgg ctccccttcc ccggaaccaa tgacctatgc
     8041 tcgacgctat aacccctacc ccagcacaca tcggtggcct cgacgcgtca gtccttgctt
     8101 ccggccgccg gctgccgtaa ctcgccccgc atgctcgcgc actcggtcgt gaatggaacc
     8161 aagacctgga ccaccccgaa cggggagctg cggctgtggc agcccgctcc gcacgtcatc
     8221 gtgacgcgct tccagggggc gatgtacgac gcccacctgg cccacctcgc catgatgagc
     8281 atcgagggaa tcgtgtccac ccagacgaag acggacgtct tccatgactg ggaggagatg
     8341 gagctctacg ccaccgaggc gcgcaccatc atgacggagc gcgccatccc gctcgcgccc
     8401 aagctcaact ccctgagcgt gctgttcggc tcgaaggtgg tgctgatggg ggtgtcgctg
     8461 gccagcctca agctgggcgg catcaacacg tacaccagcc gggaagactt cgagcaggcc
     8521 gtgcagcagg ccgcggcctc ccggcccgga acgttcaagc cgccgcactg aggtccgcgt
     8581 catgatcacc aacgtggtgt tcgacttcga cggcaccatc gccaactcga ggtccgtggt
     8641 catcgccgcg tacaaccagg tggcggagaa gcatcggttc aacccgatgg tcgaagcgga
     8701 catccccgtc ttgagcaggc tctccatccc ggagaggtgc cgcaagatgg gcgtcccgct
     8761 cctcaagctg cccttggtga tggcggaggt cggccggacc tacaagaacg tcatgggctc
     8821 ggtggtggcc ttcgacggca tgctgcccgt gctccagacg ctccaccgcc acggcctcac
     8881 ggtcggcatc atctcgacca acaatgccga gaacatccag cggttcctcg ccaggaacgg
     8941 catggaggct gttgtccagc gcatccactg ctccagcaac atgttcggca aggacaaggt
     9001 catctcccgg tacctgaaga cgtacgggct gacccccgag caggtgctct acgtcgggga
     9061 cgaagagcgg gacgtggtgg cctgcaggaa gacgaagctg cgcgtgctgt ccgtgtcgtg
     9121 ggggttcgag gtgctcgacg tcctcacgaa ggcgggcccc gacttcatcg cccatcagcc
     9181 cacggacatc ctccagcggg tggcggagct gaacgggttg cctcacctgg cgtaggcgcg
     9241 ctcgaggatc cgcccggccc cagtgttcgc tggcgttcgg gggcatccgt ttgattacgt
     9301 cccttttacg tccctgtcgt tgccggtggg cagagctcgt gccagcgcct ggcgcaccgc
     9361 cgcgcgcacc ggcgcaggca cctcgtcgcc cgggatacga cggcacagag acaccgtacg
     9421 cttgagtgag tcgcacgcct gggcacagcg cgggcagcgc gacagatggt cctcgaggcg
     9481 cacgcaggtg gcctggtcca cgtcctgcac ggcgaactcc gagagttgct gcgccagctc
     9541 cgggcacccc tgggcctggc cttgagcgct ctcccccatg agggtggaga ggtgctcgcg
     9601 tagctggagg cgcgcgcgat gcagccggct cttgagcgcc cgcacctcga tacccaccac
     9661 ctgcgccgcc tcctcggccg agagaccctc cacatctcgc aggatgagca cctcgcgcca
     9721 ggcctccggc agcgcgagga tggccgcttg caacacctcc cccatctgcc gcgcgtgggc
     9781 ggccatgtcc ggagccgcct cctccacggc aacgtgggtg gccgcgggag aatccagggg
     9841 atggaactcc tcgggggctc cggcgcgccg acggcgcaag cgaaaacagt acgtgcgggc
     9901 cacctgatac agccaggtgg acaatgccgc gccgccccgg aacgcgtgga tgcctcgaaa
     9961 ggccgcgagc agcgtctcct gaagcacctc cctggcgtcc tcctccgagc cgcacatacg
    10021 caggccgaag cggtacacct gcttctcgtg gcgggcgagg agctcatcca cggccttgtc
    10081 gtcacccgag cgcgcggcct ccatcaactg ctcatcggtt cgcgtcgaca tcaccaagcc
    10141 tcctgctcgc tctctcctat cacttctctg tcggagaacg ctcggccgcc aggaggcgct
    10201 cctggccgtc cctccaggct cgggtgaatc cttttcccgg cctcctggct ctcacggagc
    10261 agaggtttcc acatgatttt ccatcagctt ttcgacgccg ggtcctcgac tcgagaggca
    10321 aacatgacag gcttttcgct tcccctgatg ggtggggtac tcatcgggct gagtgcttcg
    10381 ctcctcctcc tcttcaacgg ccgagtggct ggcatcagcg gaatcgtcgg cgggctcctg
    10441 gcccccagcc ggggtgaggt tccctggagg ctggccttca tcgccgggct ggtagggggc
    10501 ggctttctgg tacgcgcgct gctgcccggt gccttcggcc aggagacgtc ttcgcccgct
    10561 cccggcctga cggtggcggc cggcctcctg gtgggccttg gtacgcacct gagcaacggc
    10621 tgtaccagtg gccacggcgt ctgcggcgtc agccgcggct ccatgcgttc catcgtcgcc
    10681 accctcgtct tcatggcgac gggagcactg gccgtcttcg tcctgcgcac gctcagggga
    10741 ggtgtgctgt gaagacgtcc ctctcggcgc tcctggcggg cctgttgttc gcactcgggc
    10801 tcggcgtggg ggggatgacc gatcccgccc gggtgcgggc cttcctcgat gtcacgggga
    10861 actgggatgc cagcctcgcc ttcgtcatgg cgggggcgct cggcacccat gcgctgttgc
    10921 ggcgcttcat cctgcgccac cccaagcccg tcttcgcccc ggcctttccc acggcctcgc
    10981 ggacgaaggt ggaccgccgt ctcctcgtgg gggcggccct cttcggggcc ggctggggtc
    11041 tgtccggcta ctgcccgggt cccgcgctca cctcgctggc gagcggcgca tccacggcgc
    11101 tgaccttcgt ggcggcgatg ctcggaggca tgctcctctt gcgcctgtgg gagagctccc
    11161 gcatttccca cgaggctgtc acctcgagcc gaggaggagc gtgatggccg agcagcgccc
    11221 agctgccgcc gcccctggtg atgcgcctgg aagacgagca ggcacctgtc tggctgttca
    11281 tgcgggtgtg cttctctccg tgcagatctt cggggctggc cccgaggctg atgcgtgcct
    11341 gacaccgcct ctcatatcct gctggtggag actcctcccg ctcttcagcg gcacctgcgc
    11401 ctggcactcg gtccgctcgg cctgcgcctg cattggcccg aggtggggca ggtgctcgag
    11461 tccctggacg gccggagggt cgccgcgatg gtgcttcccc tggcgagcga gggtgggctt
    11521 tccgagcgtc aggccctgcg gctgacgcgg gaggcgcacg cccgcggtgt acccgtgctg
    11581 ctgctcaccc aggagctccc cgaggcggtg cgggtgatgg ccgcccaccc ggtgggcgcg
    11641 gcggacgtgc
//
