LOCUS       NZ_CP011509            10900 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Archangium gephyra strain DSM 2261 chromosome, complete genome.
ACCESSION   NZ_CP011509
VERSION     NZ_CP011509.1
KEYWORDS    RefSeq.
SOURCE      Archangium gephyra
  ORGANISM  Archangium gephyra
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Archangium.
REFERENCE   1  (bases 1 to 12489432)
  AUTHORS   Sharma,G. and Subramanian,S.
  TITLE     Genome assembly of Archangium gephyra DSM 2261
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12489432)
  AUTHORS   Sharma,G. and Subramanian,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2015) Protein Science and Engineering, Institute
            of Microbial Technology, Sec-39 A, Chandigarh, Chandigarh 160036,
            India
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: HGAP Pipeline v. SMRT v2.3.0
            Coverage                          :: 79.3
            Sequencing Technology             :: PacBio
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001027285.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:37:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,001
            CDSs (total)                      :: 9,898
            Genes (coding)                    :: 9,822
            CDSs (with protein)               :: 9,822
            Genes (RNA)                       :: 103
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 28 of 76
            Pseudo Genes (incomplete)         :: 45 of 76
            Pseudo Genes (internal stop)      :: 6 of 76
            Pseudo Genes (multiple problems)  :: 3 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1049060
            Orig. end                         :: 1059960
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10900
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10900
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10900
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5900](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5900)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(144..797)
                     /locus_tag="AA314_RS04355"
                     /old_locus_tag="AA314_00895"
     CDS             complement(144..797)
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020480697.1"
                     /locus_tag="AA314_RS04355"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog.;
                     Presence of a B(12) (cobalamin)-binding domain implies
                     dependence on cobalamin itself, in one of its several
                     forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00895"
                     /product="cobalamin-dependent protein"
                     /protein_id="WP_047854413.1"
                     /transl_table=11
                     /translation="MTTDTIAAIRASYLSAQLAGNRREALRLLVDEGILRGIPVPTLHL
                     DVIQKAQWEIGRMWQENEISVAQEHMATAISQLALSHLYRHLQRDPPNGRVVLVSCVEG
                     ELHELGARMASDFLEMAGFDVRFLGANVPTEHLVREVLESKPDLLAFSVTMTYHLPALR
                     QAVAAVREVAPALPMAVGGLAFTWVPGVEAELGVPFFGKDARELVAAACRMFEV"
     gene            1048..1842
                     /locus_tag="AA314_RS04360"
                     /old_locus_tag="AA314_00896"
     CDS             1048..1842
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002620156.1"
                     /locus_tag="AA314_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00896"
                     /product="hypothetical protein"
                     /protein_id="WP_047854414.1"
                     /transl_table=11
                     /translation="MRSPTRTPDWLLERILLGELPPEELARARARLLEEPEGAARLAAL
                     EADTAATLVRHPSADVARRVASQARRLQARGERPARRFPSLTAALVPALAAAALVLLVR
                     PPAAGPVAPEAPVEETRVKGLEPRITIHRQRDGAAEVLVDGALAASGDVVQLAYVAAGR
                     AHGVILSVDGRGTVTLHAPESGTGSVPLAPAGTHALPGAYALDDAPGFERFFLVTAEAP
                     FALEEVLAAARSLAGRSEARTSPLPLPSRYMQASFTLEKSSP"
     gene            1839..4178
                     /locus_tag="AA314_RS04365"
                     /old_locus_tag="AA314_00897"
     CDS             1839..4178
                     /GO_function="GO:0004197 - cysteine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013374235.1"
                     /locus_tag="AA314_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00897"
                     /product="caspase family protein"
                     /protein_id="WP_047854415.1"
                     /transl_table=11
                     /translation="MSATRVLALLCVLLAVPALAETGPVRRLALLVGVNDGGPERVRLR
                     YAVSDARSFDKVLGELGGVAAADRRVLVDVGRAGLLEALGELRARTEAARGSGASRVEV
                     LVYYSGHSDEEGLLLKGERLGYGELRRALNALPADVRIAVLDSCASGAFARAKGGTRRP
                     AFLVDSGNKVKGHAILTSSSEDEVSQESDRLGASYFTHHLISGLRGAADATRDGRVTLN
                     EAYQFAFHETLARTEKTRGGAQHPAYDIELAGSGDLVMTDLRATSAGLYLAEALEGRLF
                     VRDEAGTLVVELQKLPGRPAELGLAPGRYQVRREVESGASEASFTLVEGQRTPLAPASF
                     QAIPLEATVSRGGPEVAPGAPEVDVALLDPELLERASVSEAPGLYQMQSYTRVPVSLSL
                     IPQLSTNVLKPPIWRVENQLAFGVVNGGRAVRVRGAALSLVANWYEEEAHGLLLSSGFN
                     VVKGEASGLMASPAANIALGEVEALQLAVGTNVAGGDVRVGQLAVGVNVAARSVWGVQL
                     AAGGNVAGGSLGGIQGSVGLNVTRGDFAGLQGAVGGNVAGGSVRGVQWAVGVNRASDVM
                     GLQAALLNVGGDVTGAQLGLINVARVVTGVQLGLVNVSEEVKGMPVGLLSFEKKGQFHV
                     ELYGSDIQLTNLAVKFGGKYLYTALLGGIGPDDRLERFSLGLGLGLHLPLGERLWLDGD
                     VAGSTVLRVRDPFGGSSNVLGQGRVMLGVQLFERFALFGGPTYNVYFAGSERDRYALTT
                     LPSREQEVSESTWVRYWPGVQLGIRM"
     gene            complement(4191..4997)
                     /locus_tag="AA314_RS04370"
                     /old_locus_tag="AA314_00898"
     CDS             complement(4191..4997)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AA314_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AA314_00898"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_047854416.1"
                     /transl_table=11
                     /translation="MSLAGFQRALSALVISPALRAEVAALPEPELPTQLASLELTERER
                     RRLHALARDAGMKVTTLLHRANRLSMLTNTLPRTCEAMAHPRLQPLVQRYWREHPPTSV
                     MYVREARRFAGFLQELLRSGELVHPPLAELLEAELALLELGKSGLALPAVPETPPEGDS
                     LEEARPRLGPWCRVLPFRMEPRMLLRSGGAVTLPESLPDEERYLLLTSVTPGQVVPRGL
                     DMMRGRVLRASTGEHSVAWLRAELGCPSSLFLELAREGWLLLGPAQ"
     gene            complement(5001..5900)
                     /locus_tag="AA314_RS04375"
                     /old_locus_tag="AA314_00899"
     CDS             complement(5001..5900)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016970.4"
                     /locus_tag="AA314_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00899"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_053066084.1"
                     /sec_met_domain="DUF692 (E-value: 2.3e-51, bitscore: 173.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQRRARLGVGLSYQGSLRDFVREHLEAYDFLEVIPDIFWTEERG
                     PDGALRFRENAEGLRLLDWVAARRPLVAHSVGMSLGSAEGGFSPDYVAQLARWQRRYHF
                     AWLSEHLSFTRLPHGPGEHMDLGVMLPVPYDEDTLELLAGRVAEVRRAVDAPFLLENNV
                     FYYQLPEQELSEPAFLRRLGERTGSGLLLDLHNLHTNARNHGFSPLDFLEALDLSQVVE
                     LHIAGGSEWEGFYLDAHSGACPEPVWELLEQVLPRLPNLGGVVFEMFGNYVPLLGTDVL
                     LGELRRLRDVLERHGGRP"
     gene            complement(5905..6087)
                     /locus_tag="AA314_RS04380"
                     /old_locus_tag="AA314_00900"
     CDS             complement(5905..6087)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AA314_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AA314_00900"
                     /product="hypothetical protein"
                     /protein_id="WP_047854417.1"
                     /transl_table=11
                     /translation="MTTTHSVPETLELDNDLLDTVTGGTGGTVLVPTEECPTCVSGVDP
                     TVLSSQHQNLLAGDL"
     misc_feature    complement(6092..6105)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.61"
                     /tool="antismash"
     misc_feature    complement(6098..6107)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.77"
                     /tool="antismash"
     gene            6200..6595
                     /locus_tag="AA314_RS04385"
                     /old_locus_tag="AA314_00901"
     CDS             6200..6595
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AA314_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AA314_00901"
                     /product="hypothetical protein"
                     /protein_id="WP_047854418.1"
                     /transl_table=11
                     /translation="MGICTLLGLLGGLFLIGWVALAVFFWRREREASRRHKEQLRLLGT
                     EELLARARNWGPMNRHEDLPAVVEFRSLLEQHRYEEMLQGWRALTASLFALEEHVSSAG
                     PQFYDSDSFRVLRDYVEVLHERQQRGE"
     gene            complement(6619..7761)
                     /locus_tag="AA314_RS04390"
                     /old_locus_tag="AA314_00902"
     CDS             complement(6619..7761)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022732.4"
                     /locus_tag="AA314_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00902"
                     /product="DUF3089 domain-containing protein"
                     /protein_id="WP_047861442.1"
                     /transl_table=11
                     /translation="MRNKLQRLLSATLLVCTLLLVLLGMNFASIFLWSVTPRTPFSEAR
                     APTPPDYSRPSTWSALPELHDLADTVPPSSPALEQSQAPVDVFYIHPTTYIGGEWNGPV
                     DDATLNEATDRVATLIQASAFNACCAIYAPRYRQANMTAFTGPVEKGQAALDLAYRDVA
                     AAFRYWREHFNRGRPFILAAHSQGTVLARRLLHETVSGTPLRHQLVAAYLIGIPMPEDT
                     LQRSLPDIPFCDSPEQTGCLISWNARTANATERIQVREPVLDAAPSPGPFLCVNPLTWR
                     HDTEPASWEQNPGAVFLEATPPQVMPGLTGAQCKKGKLEVLIRGDMPRDFMSRLLDHAM
                     GEGNHHPVEFQLFYMSIRRNAAERVAAFLRSNATPNTRDP"
     gene            complement(7767..8606)
                     /locus_tag="AA314_RS04395"
                     /old_locus_tag="AA314_00903"
     CDS             complement(7767..8606)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AA314_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AA314_00903"
                     /product="hypothetical protein"
                     /protein_id="WP_147332960.1"
                     /transl_table=11
                     /translation="MQSVRMQLIPTASLTDATRSELWDFTSRFVETDRQDWGRKLGAHA
                     EVILFRERGSGGLVGMAAVDFQEVSHEGRRVHIILTSSVLLDERYRGQNLLQRAGLVCF
                     LRTRLRHPLAPIYWFFVTFSYKSYLLLAFNFAEFWPRPDQAMPHWEQGLMDTLARQWYG
                     DAWDSTQGVVHHQAGKKLRAGVASISEPDLTQPHIRFFNARNPLYHEGELLVCMAPLTW
                     RNWRSILGNGLRRLMRRRPARAPQLASVTPLRVPAAKTSDTLALEESGARSKLAQHG"
     gene            complement(8664..9383)
                     /locus_tag="AA314_RS04400"
                     /old_locus_tag="AA314_00904"
     CDS             complement(8664..9383)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002611717.1"
                     /locus_tag="AA314_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00904"
                     /product="hypothetical protein"
                     /protein_id="WP_047854420.1"
                     /transl_table=11
                     /translation="MASKISDEWKVLPHGPLEQLSDNLWRVEGSLPGMSLKRVMTVVRR
                     GDGSLVIHSAIALADKERRELEALGSPSVLLVPNQGHRLDAPAYKKRYPSLRVFAPSGG
                     RQAIAEVVPVDGAYEDFPADDTVRLEMLHGVKAGEGAMFVRSKDGLTVVLNDCLFNMDR
                     KKDPLGWFFTTVLGSAPGPRVSRLVKLMFVQDKKALRADFERFAQLPGLVRLIVSHEKV
                     AHGAEAASALRQAATYL"
     misc_feature    10176..10185
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    10262..10275
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.28"
                     /tool="antismash"
     misc_feature    10429..10444
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.82"
                     /tool="antismash"
     misc_feature    10477..10493
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.19"
                     /tool="antismash"
     misc_feature    complement(10539..10556)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.19"
                     /tool="antismash"
     misc_feature    complement(10639..10657)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     misc_feature    complement(10764..10777)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     misc_feature    10866..10881
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.26"
                     /tool="antismash"
ORIGIN
        1 gacggcgtcc tcgcccccga agcgccgcgc ccgctcctcg ccgtagcggg cgaaccagaa
       61 gggatcgtcg tagagctccg agacggacgc ctcggccagc cgctgcatgc ggcgctccac
      121 ctcacgggcc aacgactgca tgcctagacc tcgaacatcc tgcaggccgc ggccaccagc
      181 tcgcgcgcgt ccttgccgaa gaaggggaca cccaattccg cctccacccc gggaacccag
      241 gtgaaggcca acccccctac ggccatgggc agtgccggtg ccacctcccg caccgccgcc
      301 accgcctggc gcaacgcggg caggtggtac gtcatggtga ccgagaacgc cagcaaatcg
      361 ggtttcgact ccagcacctc gcgcaccagg tgctcggtgg gaacgttggc acccaggaaa
      421 cggacgtcga agcccgccat ctccaggaag tcgctggcca tgcgggcgcc cagctcgtgc
      481 agctcgccct ccacgcacga caccagcacc acgcggccgt tgggcgggtc tctctgcagg
      541 tggcggtaga ggtgcgacag ggccagctgg gagatggcgg tggccatgtg ctcctgggcc
      601 acggagattt cattctcctg ccacatgcgg ccgatctccc actgggcctt ctggatgacg
      661 tccaggtgca gggtggggac gggaatgcct cggaggattc cctcgtccac gagcaggcgc
      721 agggcctccc ggcgatttcc cgcgagttgg gcggagaggt acgacgcgcg tatcgcggcg
      781 atggtgtcgg tggtcacgga tgaagatcgc gaggggggag ggggcacggt actcgggtcg
      841 gttcactcct agaagcgcgg gctgctcgat ttcccaggca gtcaacaacg gcacgaaggc
      901 gggttacgtc cgggtgcttc gctcgcctgc ttgaaagttg ggagaccaag ggcccggaac
      961 gccctcggga agaaaagcgc ggggaagagg gagacgaggt aacagcccgg ggcgggcgcg
     1021 gtgttccctt ctccggcagg aggccgcatg cgttccccga cccgcacccc cgactggctt
     1081 ctcgagagga tcctcctggg ggagctccct cccgaggagc tcgcccgcgc ccgggcccgc
     1141 ctcctggagg agccggaggg ggccgcccgg ctcgccgcgc tcgaggcgga caccgccgcc
     1201 acgctggtcc ggcacccgtc ggcggacgtc gcccggcggg tggcctccca ggcccgccgc
     1261 ctccaggccc ggggggagcg tccggcgcgc cgctttccct ccctcaccgc cgccctcgtg
     1321 ccggcgctcg cggccgcggc gctcgtcctc ctcgtgcggc ccccggcggc cggcccggtg
     1381 gccccggagg cgccggtgga ggagacgcgg gtgaagggcc tggagccgcg gatcaccatt
     1441 catcgtcagc gggacggggc ggccgaggtc ctcgtggacg gggcgctcgc ggcctccggg
     1501 gacgtggtgc aactggccta tgtggccgcg ggccgggccc atggcgtcat cctctcggtg
     1561 gacgggcgcg gcaccgtcac cctgcacgcc cccgagtccg gtacgggctc ggtgccgctg
     1621 gccccggcgg gcacccacgc gctgcccggc gcctacgcgt tggacgatgc cccgggcttc
     1681 gagcgcttct tcctcgtcac cgccgaggcc cccttcgcgc tggaggaggt gctcgccgcc
     1741 gctcgctcgc tcgctggccg ttccgaggcg cgcacctcgc cgttgcccct gccttcgcgg
     1801 tacatgcagg cctccttcac gctggagaag tcctccccat gagtgccacg agagtcctcg
     1861 ccctgctgtg tgtgctgctg gcggtgcccg cgctcgcgga gacgggcccg gtgcggcggc
     1921 tggcgctgct cgtgggtgtc aacgacgggg ggcccgagcg ggtgcggctg cgctatgcgg
     1981 tgtccgacgc gcgctccttc gacaaggtgc tgggggagct ggggggagtg gccgccgcgg
     2041 accggcgcgt gctggtggac gtggggcgcg cggggctgct ggaggcgctg ggagagctgc
     2101 gtgcgcgcac cgaggcggcc cggggctcgg gggcctcgcg cgtggaggtg ctggtgtact
     2161 actcgggcca ctcggacgag gagggcctgc tgctcaaggg cgagcgcctg ggttatggcg
     2221 agctgcgccg ggcgctcaac gcgttgcccg cggacgtgcg catcgcggtg ctggacagct
     2281 gcgcctcggg ggccttcgcc cgggcgaagg gaggcacccg tcggccggcc ttcctggtgg
     2341 actcgggcaa caaggtgaag ggccacgcca tcctcacctc ctccagcgag gacgaggtgt
     2401 cacaggagtc ggacaggctg ggcgcctcgt acttcaccca ccacctcatc tccgggctgc
     2461 gcggcgcggc ggatgccacg cgggatgggc gggtgacgct caacgaggcc taccagttcg
     2521 ccttccacga gacgctggcg cgcacggaga agacgcgggg cggggcgcag cacccggcgt
     2581 atgacattga gctggcgggc tcgggggacc tggtgatgac ggacctgagg gcgacgtcgg
     2641 cggggctgta tctcgccgag gcgctggagg gccggctctt cgtgcgggac gaggcgggca
     2701 cgctggtggt ggagctgcag aagctgccgg gccggcccgc ggagctggga ctggcgcccg
     2761 ggcgctacca ggtgcggcga gaggtggaga gcggggcctc cgaggcgagc ttcacgctgg
     2821 tggaggggca gcgcaccccg ttggcgccgg cgagtttcca ggcgattccg ttggaggcca
     2881 cggtgtcgcg gggggggccg gaggtggcgc ccggggcccc cgaggtggac gtggccctgt
     2941 tggatcccga gctcctggag cgtgccagtg tctccgaggc gccggggctg taccagatgc
     3001 agagctacac gcgggtgccg gtgtcgctga gcctcattcc gcagctgagc accaacgtgc
     3061 tgaagccgcc gatctggcgg gtggagaacc agctcgcgtt cggcgtggtg aatggaggga
     3121 gggcggtgcg ggtgaggggc gcggcgctgt cgctggtggc caactggtac gaggaggagg
     3181 cgcacggcct gctgttgtcc tcgggcttca acgtggtgaa gggggaggcg agcgggctga
     3241 tggcgtcccc ggcggcgaac atcgcgctcg gggaggtgga ggcgttgcag ctggcggtgg
     3301 ggacgaacgt ggcgggcggg gacgtgcggg tggggcagct ggcggtgggg gtgaacgtgg
     3361 cggcgcgctc ggtgtggggc gtgcagctgg ccgcgggcgg caacgtggcg ggagggagcc
     3421 tcggtggcat ccaggggagc gtgggtctca acgtgacgcg gggggatttc gcgggcctgc
     3481 agggggcggt gggggggaat gtggcggggg gctcggtgcg gggcgtgcag tgggcggtgg
     3541 gcgtcaaccg cgcgagtgac gtgatgggcc tgcaggcggc gctgttgaac gtgggcgggg
     3601 acgtgacggg ggcgcagctg ggcctcatca acgtggcccg ggtggtgacg ggcgtgcagc
     3661 tcggcctggt gaacgtctcc gaggaggtga agggcatgcc cgtggggttg ctctccttcg
     3721 agaagaaggg gcagttccac gtggagctgt acggcagcga catccagctc accaacctcg
     3781 cggtgaagtt cggcggcaag tacctgtaca cggcgctgct gggggggatt gggccggatg
     3841 accggttgga gcgcttcagc ctgggattgg ggctggggct gcacctgccg ctgggcgagc
     3901 gcctgtggct ggacggggac gtggcgggaa gcacggtgct gcgcgtgagg gacccgtttg
     3961 gaggcagctc caacgtgctg ggccaggggc gggtgatgct cggggtgcag ctcttcgagc
     4021 gcttcgcctt gttcggcggg cccacctaca acgtgtactt cgccgggagt gagcgggacc
     4081 ggtacgcgct caccacgctg ccgtcgcggg agcaggaggt gtcggagagc acctgggtgc
     4141 ggtactggcc cggcgtgcag ctcggcatcc ggatgtgagg agggcgtggc ctactgcgcc
     4201 ggaccgagga ggagccatcc ctcgcgggcc agctccagga agagcgagga cgggcagccg
     4261 agctccgcgc gaagccatgc gacggagtgc tcgccggtgc tggcccgcag gacgcgtccc
     4321 cgcatcatgt ccaagcctct cgggaccacc tggccgggcg tcacgctggt gaggagcagg
     4381 tagcgctcct cgtctggaag ggattccggc agcgtgacgg cgcctcccga gcgcagcagc
     4441 atccgaggct ccatccggaa ggggaggacg cggcaccacg ggccgagcct tggccgggcc
     4501 tcctccagcg agtctccctc gggcggcgtc tccggcacgg cgggcagggc gagccccgac
     4561 ttccccagct ccagcagggc cagctccgct tccagcagct cggcgagggg cgggtgcacg
     4621 agctcgcccg agcgcagcag ttcctggagg aacccggcga agcgccgggc ctcgcgcacg
     4681 tacatgacgc tggtgggggg gtgctcccgc cagtagcgct gcaccagggg ctggagcctg
     4741 gggtgggcca tggcctcgca ggtgcgaggc agcgtgttgg tgagcatgct cagccggttg
     4801 gcgcggtgga ggagcgtcgt caccttcatc cccgcgtccc gcgccagggc gtgcagccgg
     4861 cgccgctcgc gctccgtcag ctcgaggctc gccagctgcg tgggcagctc cggctccggg
     4921 agcgcggcca cttccgcccg cagggcgggg gagatgacga gtgcggagag cgcccgttgg
     4981 aagccggcca gggacatggc tcagggcctc ccgccgtggc gctccagcac gtcgcgcagc
     5041 cgccgcagct cgcccaggag cacgtcggtg ccgagcagcg ggacgtagtt gccgaacatc
     5101 tcgaagacga cgccgcccag gttcggcagt cgcgggagca cctgctccag cagctcccac
     5161 acgggctcgg gacacgcgcc cgagtgtgca tccaggtaga agccctccca ctcggagccg
     5221 ccggcgatgt gcagctccac cacctgcgag aggtccagcg cctccaggaa gtcgagcggc
     5281 gagaagccgt ggttgcgcgc gttggtgtgc aggttgtgga ggtccaacag gagcccgctg
     5341 ccggtgcgct ctcccaggcg ccgcaggaag gccggctcgc tcagctcctg ctcggggagc
     5401 tggtagtaga agacgttgtt ctccaggagg aagggggcgt ccacggcccg ccgcacctcg
     5461 gcgacacgtc cggcgagcag ctccagcgtg tcctcgtcat agggcactgg cagcatcacc
     5521 ccgaggtcca tgtgctcgcc gggaccgtgg ggcagacggg tgaaggacag gtgctcgctg
     5581 agccaggcga agtggtagcg ccgctgccag cgggccagct gcgcgacgta gtccggggag
     5641 aaacctccct cggcgctgcc cagcgacatg cccaccgagt gcgcgaccag cgggcggcgc
     5701 gcggccaccc aatcgagcag ccgcagcccc tcggcgttct cccggaagcg cagggcgccg
     5761 tcggggcccc gctcctccgt ccagaagatg tccgggatga cttccaggaa gtcgtaggcc
     5821 tccaggtgct cgcgcacgaa gtcgcgcagc gagccctggt aggacagtcc gactcccagt
     5881 ctggcccggc gctggctcaa gggactacag gtcgccggcc agcaggttct ggtgctggga
     5941 gctcagcacc gtcgggtcca cacccgacac gcacgtgggg cactcctcgg tgggaaccag
     6001 gacggttccg ccggtccctc ccgtcacggt gtccagaagg tcgttgtcca gctcgagggt
     6061 ctcgggaacg gagtgggtcg tggtcatgca gtcatagtaa aaaatgacag ccccgacagt
     6121 caagaccacc ctgtaacagg aaccggagtg gggacggcga gccgctgtgg agcggggcgg
     6181 tttggggtaa ctctccgcca tgggtatctg cacgctgctc ggactgctgg gcgggttgtt
     6241 cctgatcggg tgggtggccc tggcggtctt cttctggcgc agggagcggg aggcgagccg
     6301 tcgccacaag gagcaattga ggctgctcgg caccgaggag ctcctggcgc gtgcgcgcaa
     6361 ctggggcccg atgaaccgtc acgaggacct gccggcggtg gtggagttcc gctctttgct
     6421 cgagcagcac cgctacgagg agatgctgca gggctggcgc gcgctcacgg cgtccctgtt
     6481 cgctctggag gagcacgtgt cgagcgccgg cccccagttc tacgacagcg attcgttccg
     6541 cgtgttgcgc gactacgtgg aggtcctcca cgagcgccag cagcgagggg agtagccacg
     6601 gggtagcccc cagcgtcctc aggggtcccg tgtgttcggg gtggcgttcg agcggaggaa
     6661 cgccgccacc cgctcggccg cgttgcggcg gatgctcatg tagaagagct ggaactccac
     6721 gggatggtgg ttgccctcgc ccatggcgtg gtcgagcagc cggctcatga agtcccgtgg
     6781 catgtctccg cggatgagga cctccagctt tcctttcttg cactgcgcgc cggtgaggcc
     6841 tggcatcacc tggggcggtg tcgcctcgag gaacacggcc cctgggttct gctcccacga
     6901 ggctggctcc gtgtcgtgcc gccaggtcag gggattcaca cagaggaacg gccccggtga
     6961 gggcgccgcg tccagcaccg gctcgcgtac ctggattcgc tccgtggcgt tggcggtccg
     7021 tgcgttccag ctgatgaggc agccggtctg ctccggcgag tcgcagaagg ggatgtcggg
     7081 gaggctccgc tggagggtgt cctccggcat cggaatcccg atgagatacg cggcgacgag
     7141 ctggtggcgg agcggcgttc cgctcacggt ctcgtgcagg aggcgtctgg cgagcacggt
     7201 tccctggctg tgcgccgcga ggatgaaagg ccgtccgcga ttgaagtgct cccgccagta
     7261 gcggaacgcc gcggcgacgt cccggtaggc gaggtccaac gcggcctggc ccttctccac
     7321 cggcccggtg aaggcggtca tgttggcctg ccggtaccgg ggggcgtaga tggcacagca
     7381 ggcgttgaag gcactggctt gaatgagcgt cgccacccgg tcggtggctt cgttgagggt
     7441 ggcgtcatcg acgggcccat tccactcgcc gccgatatac gtggtggggt ggatgtagaa
     7501 gacatccacg ggcgcctggg actgctcgag ggccgggctc gacggcggca ccgtgtccgc
     7561 gaggtcgtgg agctcgggaa gcgcgctcca ggtggagggc cgggagtagt cgggcggggt
     7621 gggcgcacgc gcttcgctga acggggtcct gggggtgacc gaccacagga agatggacgc
     7681 gaagttcatc cccaggagca ccagcagcag ggtgcagacc aggagggtgg cggagagaag
     7741 gcgctggagc ttgttccgca tcgtcgtcac ccgtgctggg cgagcttgct ccgcgcgccg
     7801 ctttcctcga gagccagggt gtccgaagtc ttcgcggccg ggacccggag cggtgtcacg
     7861 gaggcgagct ggggggcacg agccggacgc cggcgcatca accgccgcag gccgttgccc
     7921 aggatggagc gccagttgcg ccaggtgagc ggcgccatgc agaccagcaa ctccccctcg
     7981 tggtagagcg ggttgcgcgc gttgaagaac cggatgtggg gctgcgtcag gtccggctcg
     8041 gagatggaag ccactccggc cctgagcttc ttgccggcct ggtggtgaac cacgccctgg
     8101 gtggagtccc aagcgtcgcc gtaccactga cgcgccagcg tatccatcag cccctgctcc
     8161 cagtgcggca tcgcctgatc gggccttggc cagaactcgg cgaagttgaa ggcgagcagc
     8221 aggtagctct tgtagctgaa cgtgacgaag aaccaataga tgggggccag ggggtgccgg
     8281 agtcgcgtgc gcaggaagca caccagcccg gcgcgttgga ggaggttctg gccgcggtag
     8341 cgctcgtcga gcaggacgct cgaggtgagg atgatgtgga cgcggcggcc ctcgtgggag
     8401 acctcctgga agtccaccgc cgccatgcct accagtccgc ccgagccccg ctcccggaac
     8461 aggatgacct ccgcgtgagc gccgagcttg cgcccccagt cctggcgatc ggtctcgacg
     8521 aagcgcgagg tgaagtccca cagttccgac cgcgtcgcgt ccgtcagcga cgccgtcggg
     8581 atgagctgca tgcgtaccga ttgcatgtgg ctcatcctca cccttctgtt aactgccgta
     8641 caccccccgc caccgtttgg cgctcaaaga taggtcgcgg cctgtcgcag ggcactcgcg
     8701 gcctcggcgc catgggccac cttctcgtgc gagacgatga gccgcacgag cccgggcagc
     8761 tgcgcgaagc gctcgaagtc cgcccggagc gccttcttgt cctggacgaa catgagtttg
     8821 accaggcggg acacgcgggg gcccggcgcc gagccgagta ccgtggtgaa gaaccagccg
     8881 agcggatcct tcttgcggtc catgttgaag aggcagtcgt tgagcacgac cgtcagcccg
     8941 tctttcgagc gcacgaacat ggccccttcg cccgccttca cgccgtgcag catctccagg
     9001 cggaccgtgt cgtcggcggg aaaatcctcg taggctccat cgacggggac gacctcggcg
     9061 atggcctggc gaccgccgct tggagcgaac acgcgcaggg acgggtagcg tttcttgtag
     9121 gcgggggcgt ccaggcggtg cccctggttg gggacgagga gcaccgaggg ggagcccaac
     9181 gcctcgagct cacgccgctc cttgtcggcg agggcgatgg cgctgtggat gacgagcgag
     9241 ccatcgccgc ggcgcacgac ggtcatgacg cgcttgagcg acatgcctgg cagcgaaccc
     9301 tcgacgcgcc acaggttgtc ggagagctgt tccagcggcc catggggtag caccttccac
     9361 tcatcggaaa ttttcgaggc catgggggcg ctaccctagc aggcggccga agcacacccg
     9421 cgactgcgtc gagcgcttgc gagaccccgg cacaagtaag gagcgcgggg acgacaacga
     9481 ggaggggcat ggcaggagcc atgtcggcga tgcagcgtgg tggcttgcga ttcctccgta
     9541 cggatacgac ttggagtcag atccgcgagg ggtcgagcgt gggcggggat cagcaatgcc
     9601 ggatgccctg gaggccgcag gacgagtgct tggtccttcg gttgctcatc gcgcgcctgg
     9661 gagaaccagc gggaagaaga aggcggagaa gcgtgttgac tcccaacgcg gcggtggtag
     9721 aagccgcctc ccctcggacg gaaagacgaa gccgcactgg cggcgggatc aaccggacgg
     9781 gttgaacgaa ggaataggga gtcggaagta cggggttgac tcccaacgcg gcggtggtag
     9841 aagccgcgcc ccctcggacg gaaaagcgaa gtcgcactgg cgacagaggc cccggacgaa
     9901 gcagtgaacg agacgaaata cgaagtcggc gagcgaagtt gactcccaac gtggtggtgg
     9961 tagaagccgc ctcccctcga agcggcgaaa gccgaagcgg ggtggaagag agagtcaacg
    10021 aagcgagttg acacgggaag cggaagcgaa gtagattccg cgccccctcg accggaagaa
    10081 acaaagcgca gcggcgcggt gttgactcca gacgaggcga agcagcaaag caaagcggca
    10141 acggccgctt gacagcaaag cggcttcgaa ataaagaagg cggccccgaa gttgaacagg
    10201 gtgcagccgg gaagtagaaa cacggtagca cacaagtcgc ggcggcaaca agcggctcgg
    10261 tctttgaaaa ccaaatagca agcccaagaa gaagacgatt gcggaaaccg cagtcaattc
    10321 taaacggcac ctcaagagag tcggcgtgag tcgattccga ggtgccctga acagcgaagt
    10381 caggagttcc ttagccggac cctggcgatg ccggttcaaa acacttcaaa ttacaattgg
    10441 agagtttgat cctggctcag aacgaacgct ggcggcgtgc ctaacacatg caagtcgagc
    10501 gcgaatggag caatcctagt agagcggcgc acgggtgcgt aacacgtgga taatctgcct
    10561 gggtgtctgg gataaccagt cgaaagattg gctaataccg gataagcccc cgggagcttc
    10621 ggctcttgag ggaaaaggtg gcctctgtat acaagctatc acatccagat gagtccgcgg
    10681 cccatcagct agttggcggg gtaatggccc accaaggcaa cgacgggtag ctggtctgag
    10741 aggacgatca gccacactgg aactgagaca cggtccagac tcctacggga ggcagcagtg
    10801 gggaattttg cgcaatgggc gaaagcctga cgcagcaacg ccgcgtgtgt gatgaaggtc
    10861 ttcggattgt aaagcacttt cgaccgggac gaaaaccctg
//
