LOCUS       NZ_CP011509            10837 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Archangium gephyra strain DSM 2261 chromosome, complete genome.
ACCESSION   NZ_CP011509
VERSION     NZ_CP011509.1
KEYWORDS    RefSeq.
SOURCE      Archangium gephyra
  ORGANISM  Archangium gephyra
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Archangium.
REFERENCE   1  (bases 1 to 12489432)
  AUTHORS   Sharma,G. and Subramanian,S.
  TITLE     Genome assembly of Archangium gephyra DSM 2261
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12489432)
  AUTHORS   Sharma,G. and Subramanian,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2015) Protein Science and Engineering, Institute
            of Microbial Technology, Sec-39 A, Chandigarh, Chandigarh 160036,
            India
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: HGAP Pipeline v. SMRT v2.3.0
            Coverage                          :: 79.3
            Sequencing Technology             :: PacBio
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001027285.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:37:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,001
            CDSs (total)                      :: 9,898
            Genes (coding)                    :: 9,822
            CDSs (with protein)               :: 9,822
            Genes (RNA)                       :: 103
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 28 of 76
            Pseudo Genes (incomplete)         :: 45 of 76
            Pseudo Genes (internal stop)      :: 6 of 76
            Pseudo Genes (multiple problems)  :: 3 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 627276
            Orig. end                         :: 638113
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10837
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10837
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10837
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5837](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5837
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            9..1049
                     /locus_tag="AA314_RS02710"
                     /old_locus_tag="AA314_00561"
     CDS             9..1049
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF028222.4"
                     /locus_tag="AA314_RS02710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00561"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_047854166.1"
                     /sec_met_domain="ADH_N (E-value: 4.5e-20, bitscore: 70.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.5e-08, bitscore:
                     33.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVAVFPKGREVKVIDVPEPRLRSPTQVRVRTLEVGVCGTDKEV
                     VEQKHGKPPEGEDHLIVGHECLGEVVEVGEQVKNLAPGDLVVPRVRRPCPRAECTPCRA
                     GYSDFCVTGEYTERGIQAAHGFCAELFVEEALYLHKVPRELRGVAVLTEPLTIAEKALR
                     EVAHVQTRMPWEKKEGGRAVVLGAGPVGLLGAMALMRAGFQTTMYSRAPKPNPKAEMSE
                     SLGLPYVSSKQHRVEELVKQRGRADVVYEAAGVASVGFELMKALAPNGVYVFTGVPGSE
                     EGELDEGELMKQWVMNNQVVLGTVNAAPEDFEAAVADLGRFRAKWPGGLERLITARHPP
                     RTTPRW"
     gene            1205..1846
                     /locus_tag="AA314_RS02715"
                     /old_locus_tag="AA314_00562"
     CDS             1205..1846
                     /GO_function="GO:0004061 - arylformamidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016115.4"
                     /locus_tag="AA314_RS02715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00562"
                     /product="cyclase family protein"
                     /protein_id="WP_053066028.1"
                     /transl_table=11
                     /translation="MEGVWLDISVPFGEEPSPEGVGEAPRAELPESSAQQAEWLKRAAW
                     MGTYVTAPPSLELDLEDMERLPLTATVGKARVLHLDDVDCIRADSLAEYEPRPGERLLL
                     RTRNSQREWWKRPHEDFVRLSDAAARLLIERQVACVGVDYVSRSGFQADGLAVHQLLRE
                     AGVWIIEGLDLSDVKVGVHELVCLPLNVKAEWGSPARALLRAMRGDSSVG"
     gene            1925..3790
                     /locus_tag="AA314_RS02720"
                     /old_locus_tag="AA314_00563"
     CDS             1925..3790
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631009.1"
                     /locus_tag="AA314_RS02720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00563"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_047854167.1"
                     /transl_table=11
                     /translation="MDGQQKTSRAPAIEDHGVIGDLRTVALVATDGTMDWLCFPHFDSP
                     SVFAALLDPEKGGHFRIAPEVDGERVVHKQFYWPDSNVLVTRFYSPDGVGELVDFMPMG
                     RGGHAGRVREVVRRIRVVRGELAFRVECAPAFNYGRDTHQVRILHGGASFVSETLKLTL
                     VTSVPLETDGRRVTGRFTLHEGQSAVFGLREGAPDSCHDTVMGHEASEALFRSTVDYWR
                     HWVAGCSYTGRWREVVQRSALALKLMTFEPSGAIVAAPTCSLPEAPGGVRNWDYRYVWI
                     RDAAFTVYALLRIGFKKEAGAFMRWLEARIAALPEGAPLPLMYALDGGEVPREQELWHL
                     SGYGGARPVRIGNGAAHQLQLDIYGELMDSVYLYNKHGAPISYDFWRHLRRLVDWVCEH
                     WQERDESIWEVRAGKQNFVYSKMMCWVAVDRAIRLADKRSFPADRARWLRTRDTIFEEI
                     MQKGWCAKRGAFIQSYETMALDSANLLMPLVFFLSPVDPRMLSMLDILRKPPAQGGLAS
                     DGLVFRYDAEATEDGVSRGREGTFNLCTFWMVEAMTRASVTRPDLLDEARLTFERMLGY
                     ANHVGLYAEQTGPSGEALGNFPQALTHLSLISAAYNLDRALGHRD"
     misc_feature    4003..4018
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            4102..5004
                     /locus_tag="AA314_RS02725"
                     /old_locus_tag="AA314_00564"
     CDS             4102..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631010.1"
                     /locus_tag="AA314_RS02725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00564"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_047854168.1"
                     /transl_table=11
                     /translation="MNPLDWNGEQFLEAYLPFGLVMLIAASLWRSLLKWSEPSEEPRPG
                     ELELDPYQVAMLERREGGVRAAVAALVHAGALRFESGVLKAVDGPPLRLLPFERAVYEA
                     VAGGLKEVSQLETKLSRELDRMEEGLRQRGLLLSPEMAERYKYPRFLFYGVALGLGGMK
                     LLVGLWRDKPVGYLVIVILFGMMMGSLLLQGAPRRTKRGDKALAMLRRDNEALRTTAKA
                     DGAWGAMSSGSVAMAVALFGTGLLAASGMGDLRDYLVPPGSGGSDIGGDSGGGGDGGGD
                     GGSSCGGGGCGGCGGGGGD"
     gene            5001..5837
                     /locus_tag="AA314_RS02730"
                     /old_locus_tag="AA314_00565"
     CDS             5001..5837
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002631011.1"
                     /locus_tag="AA314_RS02730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00565"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_047854169.1"
                     /sec_met_domain="DUF692 (E-value: 4.7e-81, bitscore: 271.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPPAGVGLGWRRQLAHYLDEAERVDFVEVLAEHLDPKGPLPEPL
                     KRLKERGVPVVLHGVSLGLGSAEPPERGRLDMLARLAERLGAVCVSEHLAFVRAGGVES
                     GHLLPLPRTGEMLEVLAENVRRAEAALPVPLALENVASLFEWPGEGMTEARWLAGVLER
                     TGVGVLLDVANLYANTLNHGTDAEEVLEAVPRERLAYVHVAGGVKRGGLYHDTHAHGVP
                     EGPLVLLEKLVARVGPVPALLEWDDHFPPPEVLGAELEAMKAAQARGVARWKGGGA"
     gene            5834..6325
                     /locus_tag="AA314_RS02735"
                     /old_locus_tag="AA314_00566"
     CDS             5834..6325
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002639677.1"
                     /locus_tag="AA314_RS02735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00566"
                     /product="hypothetical protein"
                     /protein_id="WP_047854170.1"
                     /transl_table=11
                     /translation="MSARERLAKAQAELARALGMGEPVPAGFDAERVGAAAEALGMKRR
                     RLVQRTWPMLAAALGGDFARSFETWARENPLLGVEPNPLADGRRFAGSLRVAGAFPVEA
                     EEEWIHFELRWRLTKEGGVEARRGVVLKTARVGRAKRRMLAVRLPGGRVLWWSSHRGSR
                     "
     gene            6627..10232
                     /locus_tag="AA314_RS58250"
                     /old_locus_tag="AA314_00567"
     CDS             6627..10232
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="AA314_RS58250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AA314_00567"
                     /product="hypothetical protein"
                     /protein_id="WP_053066029.1"
                     /transl_table=11
                     /translation="MRNEPLAAHPTPPDARPYRGLLAFEPEHRRFFFGRGELERELVLR
                     VRASMGGWGSRFQVVVGASGSGKSSLVLAGLVPRLHEDAREPWDTVVLRPGEAGAPRML
                     EVEEGPGRFSSLGRLRALLSGLHGQGGASTGQGATVAEVLREAKRLREAGPERWLLVVV
                     DQLEELFTQVSTVEEREALMRALWRLAHTPEVRVVVVATLRVDALGRCEHVRVDHEGPQ
                     LESVVYSAAHRLFVGPPRAEQLADVIEGPARVVGLELEPGLVEVLRRDVEQEPGALPLL
                     QHALDQLWERRTGSRLTRAAYEELGGVVGAMARTGDRLYESLPEAERHQARRLLARLVD
                     LREEMSPHARREGLKQLRPEREDEAAAFDAVVEKLVRHRLVVRGEDGGQPPEPWLRLAH
                     EALIRRWGRLVEWVREGRKQEPRASEAETRERERTRYARDVARVLQARRLLEWDLALAV
                     LVLREVAEPERTPEWHPSVLEALHRGAMQPQVLAGHEGRVELAAFSADGERVLTGSADG
                     TARVWRGDGAGEPVVLGGHEGGVWSAELSADGARVLTTSQEGRVRVWRADGAGEPVVLA
                     AYEERVWPAEFSPDGQRVLSVSEDGTVRVGLADGTGEPVMLRGHGGRVLSAAFSADGER
                     VLTASEDGTARVWRADGTGRPGVLVGHAGTVRSAAFSPDGQRVVTASEDGTARVWRADG
                     TGEPVVLVGHAGAVTRAEFSPDGQQVVTASQDGTARVWRVDGTGEPVVLAGHAAAVASA
                     AFSADGQRVVTASEDGTARVWRADGTGASVVLRGHVAEVRSAEFSPDGQRVLTASEDGT
                     ARVWNGLGEPVVLAGHEGAVTRAVFSADGQRVLTASEDGAVRVWRADGAGEPVMLAGPE
                     GEVGAGAFSPDGERVVTASRAGTVRVWRADGAGEPVVLAGYLAMLWPAKLSADGERVLT
                     KSQEGAVRVWRVDGAGGPVVLRGHEEEVWSAEFSPDGQWVLTRSQDGTARVWRADGTGE
                     PVVLAGHTGGVRAAELSADLQRVVTVAEDGTVRVWKADGTGEPRVLVGPEAEVELAAFS
                     ADGQRVLTASRDGTVRVWRADGTGEPMVLRGHEGRVERAAFSADGERVLTASEDGTVRV
                     WRADGTGEPVVLGGPEGRMERAAFSAEGDRVLSVAEDGTVRLWTVGTARLQALLREAVT
                     GSLTPEQRQRYLLETPEEARAGYEQCERERTGLPR"
     misc_feature    complement(10640..10653)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.28"
                     /tool="antismash"
     misc_feature    10691..10704
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
ORIGIN
        1 aggtggcgat gaaggcggtg gccgtgttcc cgaagggccg cgaggtgaag gtcatcgacg
       61 tgccggagcc caggctgcgc tcgcccaccc aggtgcgggt gcgcacgctg gaggtgggcg
      121 tgtgtggcac cgacaaggag gtggtggagc agaagcacgg caagcctccc gagggggagg
      181 accacctcat cgtcggccac gagtgtctgg gcgaggtggt ggaggtgggc gagcaggtga
      241 agaatctcgc gcccggggac ctggtggtgc cgcgggtgcg ccgcccctgc ccccgggccg
      301 agtgcacccc gtgccgggcg gggtactcgg acttctgcgt caccggcgag tacaccgagc
      361 ggggcattca agcggcccac ggcttctgcg cggagctctt cgtggaggag gcgctctacc
      421 tgcacaaggt gccacgcgag ctgcggggcg tggcggtgct gacggagccg ctcaccatcg
      481 ccgagaaggc gctgcgcgag gtggcgcacg tgcagacgcg catgccctgg gagaagaagg
      541 agggcggccg ggcggtggtg ctgggcgcgg ggccggtggg cctgctgggc gccatggcgc
      601 tgatgcgcgc gggcttccag acgacgatgt actcgcgtgc ccccaagccc aacccgaagg
      661 cggagatgtc cgagtcgctg ggcctgccct acgtgtcctc caagcagcac cgggtggagg
      721 agctggtgaa gcagcgcggc cgggcggacg tggtgtacga ggcggcgggc gtggccagcg
      781 tcggcttcga gctgatgaag gccctggccc ccaacggcgt gtatgtcttc accggcgtgc
      841 ccggcagcga ggaaggcgag ctggacgagg gcgagctgat gaagcagtgg gtgatgaaca
      901 accaggtggt gctcggcacg gtgaacgcgg cgccggagga cttcgaggcg gcggtggcgg
      961 acctcgggcg cttccgcgcg aagtggcccg gcggactgga gcggctcatc accgcccgcc
     1021 accccccgag gactacgccg aggtggtgac gggtcggaag ggaagccaca tcaaggacat
     1081 catcgtcttt tcccgggggt gagaaacggg tgacactgcg taggtcccct ctccccctgg
     1141 gagagggtta gggtgagggt ctctcaaccc cagaggacac ccgagtcccg aagaggagaa
     1201 gcacatggag ggagtctggc tggacatctc ggtgccgttc ggtgaggagc cctcgccgga
     1261 gggcgtgggt gaggccccga gggcggagct cccggagagc tcggcgcagc aggccgagtg
     1321 gctcaagcgc gcggcgtgga tggggacgta cgtgacggcg ccgccgagcc tggagctgga
     1381 cctggaggac atggagcggc tgccgctgac ggccacggtg ggcaaggcgc gcgtgctgca
     1441 cctggacgac gtggactgca tccgggccga ctcgctggcc gagtacgagc cgaggccggg
     1501 ggagcggttg ctgctgcgca cgcgcaactc gcagcgcgag tggtggaagc ggccgcatga
     1561 ggacttcgtg cgcctgtcgg acgcggcggc gcggctgctc atcgagcgcc aggtggcgtg
     1621 cgtgggcgtg gactacgtgt cgcgctcggg cttccaggcg gatggcctgg ccgtgcacca
     1681 gctgctgcgc gaggccgggg tgtggatcat cgaggggctc gacttgagcg acgtgaaggt
     1741 gggggtgcac gagctggtgt gcctgccgct gaacgtgaag gcggagtggg gctcgcccgc
     1801 ccgggcgctg ctgcgggcga tgcgcggcga ctcgtccgtg gggtagccgg ggaggcgggg
     1861 actggcctcc cgtcacctcg ggcccaccgg acgcatacat ctcctggacg gggaggtgtc
     1921 ggccatggat gggcagcaga agacgtcccg agctccagcc atcgaggacc acggcgtcat
     1981 cggggacctg cgcacggtcg ccctggtggc gacggacggg acgatggact ggctatgctt
     2041 cccccacttc gacagcccga gcgtcttcgc ggcgctgttg gaccccgaga agggcgggca
     2101 cttccgcatt gccccggagg tggacgggga gcgggtggtg cacaagcagt tctattggcc
     2161 ggacagcaac gtgctggtga cgcgcttcta ctcgccggac ggggtgggcg agctggtgga
     2221 cttcatgccc atgggccggg ggggccacgc gggccgggtg cgcgaggtgg tgcggcgcat
     2281 ccgcgtggtg cgcggcgagc tggccttccg cgtggagtgc gcgccggcct tcaactacgg
     2341 ccgggacacg caccaggtgc ggattctgca cggcggggcg agcttcgtgt cggagacgct
     2401 gaagctgacg ctggtgacgt cggtgccgct ggagacggac gggcggcgcg tcaccgggcg
     2461 cttcacgctg cacgagggac agtcggcggt gttcggcctg cgcgagggcg caccggactc
     2521 gtgccatgac acggtgatgg ggcacgaggc ctcggaggcg ctgttccgga gcacggtgga
     2581 ctactggcgg cactgggttg cggggtgcag ctacacgggg cggtggcgcg aggtggtgca
     2641 gcgctcggcg ctggcgctca agctgatgac gttcgagccc tcgggggcca tcgtcgcggc
     2701 gcccacgtgc agcctgcccg aggcaccggg cggcgtgcgc aactgggact accgctacgt
     2761 gtggattcgc gacgcggcct tcacggtgta cgcgctcttg cgcattggct tcaagaagga
     2821 ggcgggggcc ttcatgcgct ggctggaggc ccgcatcgcg gcgctacccg agggagcgcc
     2881 cttgcccctc atgtatgcgt tggacggcgg cgaagtgccc agggagcagg agttgtggca
     2941 cctgtctggc tatgggggcg cgaggccggt gcgcatcggc aacggggcgg cgcaccagct
     3001 gcagctggac atctacgggg agctgatgga ctcggtgtac ctgtacaaca agcacggggc
     3061 gcccatctcg tatgacttct ggaggcacct gcggcggctg gtggactggg tgtgcgagca
     3121 ctggcaggag cgggacgaga gcatctggga ggtgagggcg gggaagcaga acttcgtgta
     3181 ctcgaagatg atgtgctggg tggcggtgga tcgggcgatc cggctggcgg acaagcgcag
     3241 cttcccggcg gaccgggcgc ggtggctgcg cacgcgcgac accatcttcg aggagatcat
     3301 gcagaagggc tggtgcgcga agcggggcgc gttcatccag tcgtacgaga cgatggcgtt
     3361 ggactcggcg aacctgctga tgccgctggt gttcttcctg tcgccagtgg acccgaggat
     3421 gctgtcgatg ctggacatcc tccgcaagcc accggcgcaa ggagggctgg cgtcggacgg
     3481 gctggtgttc cgctacgacg cggaggcgac ggaggacggg gtgtcgaggg ggagggaggg
     3541 cacgttcaac ctgtgcacct tctggatggt ggaggcgatg acgcgggcga gcgtgacgag
     3601 gccggatctg ctggacgagg cgcggctgac gttcgagcgg atgctgggct acgcgaacca
     3661 cgtgggactg tacgcggagc agacggggcc ctcgggcgag gcactgggca acttcccgca
     3721 ggccctcacg cacctgtcgc tcatcagcgc ggcctacaac ctggatcgtg cgctggggca
     3781 ccgggactga gccgcccgcc gggcgcgctc gtctccaact ggtccaacaa tcggaccagt
     3841 tcgcgcccat cgtcaccgga aggctcctcc gcgcctgcct cccctcgccc tccgggagag
     3901 ggtcagggtg agggggccac ggctcccggg ttgccccggt gtgaggcgcc gcggctccca
     3961 tgagacactc cgggccgggt gtcaccgtcc cgccccccgc gagtcacgcg gatgtcacag
     4021 gaggagccgt tacctccggg gtgttcttcc tgcaagggaa ggcgaaaccc gagaagggcg
     4081 aaggcccgga ggagggaagc catgaacccg ttggattgga atggcgagca gttcctggaa
     4141 gcgtacctgc cgttcggcct ggtgatgctg atcgcggcga gtctctggcg gtccctgttg
     4201 aagtggagcg agccgtcgga ggagccgcgc cccggcgagt tggagctgga cccctaccag
     4261 gtggcgatgc tcgagcggag ggagggcggg gtgagggcgg cggtggcggc gctggtgcat
     4321 gccggggcgc tgcgattcga gagcggggtg ctgaaggcgg tggacgggcc gccgctgcgg
     4381 ctgctgccct tcgagcgcgc ggtgtacgag gcggtggccg gtggactgaa ggaggtctcg
     4441 cagctggaga cgaagctgag ccgggagctc gaccggatgg aggaggggct gcgtcagcgg
     4501 ggcctgctgc tgagtcccga gatggccgag cggtacaagt acccgaggtt cctcttctac
     4561 ggagtggcgc tggggctggg agggatgaag ctgctggtgg ggctgtggcg cgacaagccg
     4621 gtggggtacc tggtgatcgt gatcctcttc ggcatgatga tgggctccct gctgttgcag
     4681 ggcgcgccgc ggcgcacgaa gcggggtgac aaggcgctgg cgatgctgcg gcgggacaac
     4741 gaggcgctgc ggacgacggc gaaggcggac ggggcgtggg gggcgatgag cagcgggagt
     4801 gtggcgatgg cggtggcgct cttcgggacg gggctgctgg cggcctcggg gatgggagac
     4861 ctgcgcgact acctggtgcc gccggggagc gggggttccg acatcggggg tgacagtgga
     4921 ggaggcggcg acggcggagg agacgggggc agcagttgcg gcggcggagg ctgcggcggt
     4981 tgtgggggtg gaggcgggga ttgaagccgc ccgcgggagt ggggctgggg tggaggaggc
     5041 agctggcgca ctacctcgac gaggcggagc gggtggactt cgtggaggtg ctggccgagc
     5101 acctggatcc aaagggcccg ctgccggagc cgctgaagcg gctgaaggag cggggagtgc
     5161 cggtggtgct gcacggggtg tcgctggggc tggggagcgc ggagccgccg gagcgcggga
     5221 ggctggacat gctggcgcgg ctggccgagc ggctgggcgc ggtatgcgtg agcgagcacc
     5281 tggccttcgt gagagcggga ggagtggaga gcgggcacct gctgccgctg ccgcgcacgg
     5341 gggagatgtt ggaggtgctg gcggagaacg tgcggcgggc ggaggcggcg ctgccggtgc
     5401 cgttggcact ggagaacgtg gcgagcctct tcgagtggcc gggcgagggg atgacggagg
     5461 cccggtggct ggcgggggtg ctggagcgga cgggggtggg ggtgctgctg gacgtggcga
     5521 acctgtacgc gaacacgctc aaccacggga cggacgcgga ggaggtgctg gaggcggtgc
     5581 ctcgggagcg gctggcctac gtgcacgtgg cgggaggggt gaagcgcggg ggcctgtacc
     5641 acgacacgca cgcgcacggg gtgcccgagg ggccgctggt gctgctggag aagctggtgg
     5701 cgcgggtggg gccggtgccg gcgctgctcg agtgggatga ccacttccca ccgccggagg
     5761 tgctcggcgc ggagctggag gcgatgaagg cggcgcaggc gcgaggcgtg gcgcggtgga
     5821 agggtggggg cgcatgagcg cgcgcgagag attggcgaag gcgcaggcgg agctggcgcg
     5881 agcgttgggg atgggagagc cggtgcccgc gggcttcgac gcggagcggg tgggagcggc
     5941 ggccgaggca ctggggatga agcgccggag gctggtgcag cggacgtggc cgatgctggc
     6001 ggcggcgttg ggaggggact tcgcgagaag cttcgagacg tgggcgcggg agaatccgtt
     6061 gctgggagtg gagccgaatc cgttggcgga cgggaggcgc ttcgccggaa gcctgcgagt
     6121 ggcgggagcc ttcccggtgg aggcggagga ggagtggatc cacttcgagc tgcgctggag
     6181 gctgacgaag gagggaggag tggaggcgag gaggggcgtg gtgctgaaga cagcccgggt
     6241 gggcagggcg aagcgaagga tgctggcggt gcgtctaccc ggaggccggg tcctctggtg
     6301 gagcagccat cgaggaagtc gctgaatcag cacgatcgag cgctcatctg gcacggatcc
     6361 ggacacatat cccctcgccc tccgggagag ggacggggtg agggtatcga gtgtcccagg
     6421 ttgtgcccgt gtcagctccc tcgccctctg ggagagggtt ggggtgaggg tctggagacc
     6481 cgcttcttca tcatggtgtg tgactccagg tgttgacggg gtaggcccgg tttcactcgt
     6541 gccgcgtctg ctggagaagc tcgcccggct cccggacagc ctgtgtgagg cccctgtcca
     6601 agccccccgg ctgctaagct gcgcccgtgc ggaacgagcc tctcgcggcc cacccaactc
     6661 ctcccgacgc ccggccctac cggggcctgc tggccttcga gcccgagcac cgccgcttct
     6721 tcttcggacg cggcgagctg gagcgcgagc tggtgctgcg cgtccgtgcg tcgatgggag
     6781 gctggggctc gcgcttccag gtggtggtgg gggcctcggg gagcggcaag tcctcgctgg
     6841 tgctggccgg gctggtgcct cgcctgcacg aggacgcgcg tgagccctgg gacaccgtcg
     6901 tgctgcggcc cggcgaggcc ggcgccccgc ggatgctcga ggtggaggag ggcccgggcc
     6961 gcttcagctc gctcggccgg ctgcgcgcgc tgctctccgg actccacggc cagggcggag
     7021 cgtccacggg ccagggggcc accgtcgccg aggtcctccg cgaagcgaaa cggctgcgcg
     7081 aggcggggcc ggagcggtgg ctgctggtgg tggtggatca gctcgaggag ctcttcaccc
     7141 aggtgtccac ggtggaggag cgcgaggccc tcatgcgggc gctgtggagg ctggcgcaca
     7201 cgccggaggt gcgggtggtg gtggtggcca cgctgcgggt ggacgcgctc gggcgctgcg
     7261 agcacgtgcg ggtggaccac gaggggccgc agctggagtc ggtggtgtac tcggcggcgc
     7321 accggctctt cgtgggcccg ccgcgggccg agcagctcgc ggacgtcatc gagggcccgg
     7381 cgcgggtggt ggggctggag ctggagccgg ggctggtgga ggtgctgcgg cgggacgtgg
     7441 agcaggagcc cggagcgctc ccgttgctgc agcatgcgct ggaccagctc tgggagcggc
     7501 ggacggggag ccggctgacg cgggcggcgt acgaggaact gggcggggtg gtgggggcga
     7561 tggcgcgcac gggagaccgg ctctacgagt cgctgcccga ggcggagcgg caccaggcgc
     7621 ggaggctgtt ggcgaggctg gtggacctgc gcgaggagat gagcccgcac gcgcggcgcg
     7681 aggggttgaa gcagctgcgc ccggagcggg aggacgaggc ggcggcgttc gacgcggtgg
     7741 tggagaagct ggtgcggcac cggctggtgg tgcggggcga ggacggggga cagccgccgg
     7801 agccgtggct gaggctggcg cacgaggcgt tgatccgccg gtggggccgg ctggtggagt
     7861 gggtgcggga gggccgcaag caggagccgc gggcgagcga ggcggagacg cgggagcgcg
     7921 agcgcacgcg gtatgcgagg gacgtggcgc gggtgctcca ggcgaggcgg ctgctcgagt
     7981 gggacctggc gctggcggtg ctggtgctgc gcgaggtggc ggagccggag cggacgccgg
     8041 agtggcaccc gagcgtgctc gaggcgctgc accggggggc gatgcagccg caggtgctcg
     8101 cgggccacga ggggcgggtg gagctcgcgg ccttcagcgc ggacggcgag cgggtgctga
     8161 cgggctcggc ggacgggacg gcgcgggtgt ggagggggga cggtgcgggc gagccggtgg
     8221 tgctcggggg acatgaggga ggcgtgtggt ccgcggagct gagcgcggac ggcgcgcggg
     8281 tgctcaccac gtcgcaggag ggacgggtgc gggtgtggag ggcggacggt gcgggcgagc
     8341 cggtggtgct cgcggcgtac gaggagcggg tgtggcccgc ggagttcagt ccggacgggc
     8401 agcgggtgct cagcgtgtcc gaggacggca cggtgcgggt ggggctcgcg gatggcacgg
     8461 gcgagcccgt catgctgcgg ggccatggag gccgggtgct gagcgcggcg ttcagcgcgg
     8521 acggcgagcg ggtgctcacg gcctcggagg acgggacggc gcgggtgtgg cgggcggacg
     8581 gcacgggcag gcccggggtg ctcgtgggcc acgctggcac cgtgcgctcg gcggccttca
     8641 gcccggacgg gcagcgggtg gtgacggcct cggaggatgg aacggcgcgg gtgtggcgag
     8701 cggatggcac gggcgagccg gtggtgctcg tggggcacgc gggcgcggtg acgcgcgcgg
     8761 aattcagccc ggacgggcag caggtggtga cggcgtcgca ggacgggacg gcgcgggtgt
     8821 ggcgagtgga cggcacgggc gagccggtgg tgctcgcggg gcacgcggcg gcggtggcga
     8881 gcgcggcgtt cagcgcggac ggccagcggg tggtgacggc gtcggaggac ggaacggcgc
     8941 gggtgtggcg agcggacggc acgggagcgt ccgtggtgct ccggggacac gtggcggagg
     9001 tgcgctcggc ggagttcagc ccggacggac agcgggtgct cacggcgtcg gaggacggga
     9061 cggcacgggt gtggaatggc ctcggagagc cggtggtgct cgcgggccac gagggcgcgg
     9121 tgacgcgcgc ggtgttcagc gcggacgggc agcgggtgct gacggcctcg gaggacgggg
     9181 cggtgcgggt gtggagggcg gatggcgccg gcgagccggt gatgctcgcg ggcccggaag
     9241 gagaagtggg agccggggcc ttcagtccgg acggcgagcg ggtggtgacg gcctcgcggg
     9301 cggggacggt gcgggtgtgg agggcggatg gtgcgggcga gcccgtggtg ctcgcggggt
     9361 acctggcgat gttgtggccc gcgaagctga gcgcggacgg cgagcgggtg ctcaccaagt
     9421 cccaggaagg ggcggtgcgg gtgtggaggg tggacggcgc gggcgggccc gtggtgctgc
     9481 gaggccatga ggaagaggtg tggtccgcgg agttcagccc ggacgggcag tgggtgctca
     9541 cccggtcgca ggatgggacg gcgcgggtgt ggagggcgga cggcacgggc gagcccgtgg
     9601 tgctcgcggg ccacacggga ggagtgaggg ccgcggagct cagcgcggac ctccagcggg
     9661 tggtcaccgt ggccgaggac gggacggtgc gcgtgtggaa ggcggatggc acgggcgagc
     9721 cgcgcgtgct cgtgggcccg gaagcggagg tggagctcgc ggccttcagc gcggacgggc
     9781 agcgggtgct gacggcgtca cgggacggaa cggtgcgggt gtggagggcg gacggcacgg
     9841 gcgagcccat ggtgctccga ggccatgaag gacgggtgga gcgcgcggcc ttcagtgcgg
     9901 acggcgagcg ggtactgacg gcctcggagg acgggacggt gcgggtgtgg agggcggatg
     9961 gcacgggcga gcccgtggtg ctgggtggac ccgaaggacg gatggagcgc gcggcgttca
    10021 gcgcggaggg cgatcgggtg ctctcggtgg cggaggacgg gacggtgcgc ctctggacgg
    10081 taggcacggc ccggctccag gcgctgctgc gcgaggcggt cacggggagc ctgacgccag
    10141 agcagcgcca acgctacctg ctcgagacgc ccgaagaggc gcgggcaggt tatgagcagt
    10201 gtgagcgcga gaggaccgga ctccctcgtt gatgagcggt gaaggaggag cgcgtcacat
    10261 cctgcatgcc tcgtagtgac gggagaggtg ggttgcgaga gggtaactga gcgagtagtg
    10321 tgcacgcgct gaatgccatc tcgtttgtca ctgcccaccg gttacgtcac gttcctggag
    10381 gaactgaagg caggtatccg tcaggctcag gttcgtgcgg tgcttgcggc gaactccgag
    10441 ctcgtcttgc tgtattggcg gatgggccgg aagctcctgg agcagcagtc acgggaaggg
    10501 tggggtgcac aggtcatcga gcggctcagc gcggatttgc agcgggcctt tccttcgatg
    10561 aagggcttct ccgtgcgtaa cctgaagtac atgcggacct ttgccgaggc ttggcccgat
    10621 gagcgaattg tgcaacaggt tgttgcacaa attccctggg gtcaccacct ccggctactc
    10681 gaccgtgtcc gtgacccgga tcatcgactc ttctacgtgc accaggttct cgagcatggt
    10741 tggtcccgca gcgtgttgat gcatcagatc gaagggggtc ttcacaaacg gcagggacat
    10801 gccatcacca acttcgctcg aacgttgccc tctcctc
//
