LOCUS       NZ_LN831790            10201 bp    DNA     linear   CON 08-APR-2024
DEFINITION  Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 =
            NRRL B-24963) chromosome 1.
ACCESSION   NZ_LN831790
VERSION     NZ_LN831790.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Gomez-Escribano,P.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2015) JIC, Department of Molecular Microbiology,
            Norwich Research Park, Norwich, NR4 7UH, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001013905.1-RS_2024_04_08
            Annotation Date                   :: 04/08/2024 03:45:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,096
            CDSs (total)                      :: 7,005
            Genes (coding)                    :: 6,806
            CDSs (with protein)               :: 6,806
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 82 of 199
            Pseudo Genes (incomplete)         :: 160 of 199
            Pseudo Genes (internal stop)      :: 10 of 199
            Pseudo Genes (multiple problems)  :: 49 of 199
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:33:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3683198
            Orig. end                         :: 3693399
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN831790.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10201
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="23"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10201
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10201
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5201](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5201)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(450..463)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.16"
                     /tool="antismash"
     gene            complement(700..1305)
                     /locus_tag="BN2145_RS16830"
                     /old_locus_tag="ABM27_RS16565"
     CDS             complement(700..1305)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133142.1"
                     /locus_tag="BN2145_RS16830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16565"
                     /product="hypothetical protein"
                     /protein_id="WP_029381074.1"
                     /transl_table=11
                     /translation="MLTIHADSRGRALAVEGAWIAEAGPLEEVAAARPGARLRRWPGIL
                     TPGLVNPYGDELLEGAYHPDPREADELGTEPLTGRALAALAPDEARWGASARRGLQRML
                     SHGTVAVACGELRIRAVRDAVHRSGLAVVGRIGRPGGVPSLDPYACGAPVTFAPPRERG
                     SAARFAVFDVPDEAALAERGAAACVATVVAGRLVYRRR"
     gene            complement(1314..2510)
                     /gene="mqnC"
                     /locus_tag="BN2145_RS16835"
                     /old_locus_tag="ABM27_RS16570"
     CDS             complement(1314..2510)
                     /EC_number="1.21.98.1"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mqnC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437621.1"
                     /locus_tag="BN2145_RS16835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16570"
                     /product="cyclic dehypoxanthinyl futalosine synthase"
                     /protein_id="WP_029381075.1"
                     /sec_met_domain="PF04055 (E-value: 1.5e-17, bitscore: 63.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKADLQPILDRAAAGGRITPDEALALYRDAPLHALGAAADAVR
                     RRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAPPKSDKGWTRDLDDILRRCAETV
                     ELGGTQIMFQGGHHPDFGVEYYEKHFAAIKKEFPQLVIHSLGASEVEHMARISGVSVEE
                     AITRIRDAGLDSFAGAGAELLPERPRKAIAPLKESGERWLEIMEIAHRLGVESTSTMLM
                     GTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPENNHLKGRTQATIFEYLRMIAIA
                     RLFLDNVAHIQGSWLTTGKEVGQLSLHYGADDLGSIMLEENVVSSAGARHRSNRLEIID
                     LIRKAGRVPAQRSTTYEHLVVHDDPANDPVDDRVVSHISSTAIEGGTAHPELKLLASN"
     gene            complement(2581..3474)
                     /locus_tag="BN2145_RS37155"
     CDS             complement(2581..3474)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445156.1"
                     /locus_tag="BN2145_RS37155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_049976671.1"
                     /transl_table=11
                     /translation="MYHGRIDPRREHSATNMQTSNDMGTGRHRRPAEAFTGHLMPPDWN
                     WDPAEELAFMLRDALEEQPPGDPYPEASVTAPAPGTPLGNLQEITAELPPLKDSPKGHR
                     KVREPRRINGRRAVSHFLAASVAAIACAVSVFGGVFSYESLLRSAASRTGSDMVSWWPF
                     LVYGPWMVASLSVLRAALYQRRAVHSWSVVLFFSCMAMLLCVAQLPVTLVDAATATLPG
                     LASLACFQQLVRQITLTRPPRRVIPRHRLRPMPVPDPGEPARTTARESASLPKQRTSAM
                     VRGGEERVRRTGLGGA"
     misc_feature    complement(3836..3851)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.99"
                     /tool="antismash"
     misc_feature    3845..3858
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.04"
                     /tool="antismash"
     gene            complement(3905..4714)
                     /locus_tag="BN2145_RS16850"
                     /old_locus_tag="ABM27_RS16580"
     CDS             complement(3905..4714)
                     /EC_number="3.4.23.43"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328431.1"
                     /locus_tag="BN2145_RS16850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16580"
                     /product="prepilin peptidase"
                     /protein_id="WP_047121841.1"
                     /transl_table=11
                     /translation="MSVLPAVVAAALWGAATGALLPRAAYRFSVPPDESWRTECPAGHP
                     VRGWLGPARCGPCAAAGAPPQAPPGAPPGSGTGPSYGPGAPAFATATLVVCAALAAATG
                     PRPELAVWLLLAPAGVLLAAVDLRVRRLPDLLTLPLAGAALALLGLAARVPGHAGGWTT
                     ALLGSLALGGGYFVLFLLNPEGMGFGDVKLALGAGAVLGWYGWATLALGAVAGLLLGAL
                     YGWALVAVRRGGRGTAVPYGPFLIAGALLGVLAGACRHGPFPFLVPA"
     gene            complement(5001..5201)
                     /locus_tag="BN2145_RS16855"
                     /old_locus_tag="ABM27_RS16585"
     CDS             complement(5001..5201)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944279.1"
                     /locus_tag="BN2145_RS16855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16585"
                     /product="hypothetical protein"
                     /protein_id="WP_029381078.1"
                     /sec_met_domain="strepbact (E-value: 1.3e-14, bitscore:
                     53.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLTPQVETAEMSEADLDNIAGGLAAGASAGVFAEVDAVAAVCAG
                     VGVGVNVEGVSADVVAHVAAL"
     misc_feature    complement(5220..5236)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    complement(5372..5383)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.29"
                     /tool="antismash"
     misc_feature    5681..5696
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            complement(5693..6541)
                     /locus_tag="BN2145_RS16860"
                     /old_locus_tag="ABM27_RS16590"
     CDS             complement(5693..6541)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383949.1"
                     /locus_tag="BN2145_RS16860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16590"
                     /product="menaquinone biosynthesis protein"
                     /protein_id="WP_029381079.1"
                     /transl_table=11
                     /translation="MDNSRTRPRVGHIQFLNCLPLYWGLARTGTLLDFELTKDTPEKLS
                     EQLVRGDLDIGPITLVEFLKHADRLVAFPDIAVGCDGPVMSCVIVSQVPLERLDGARVA
                     LGSTSRTSVRLARLLLEERIGVRPDYYTCPPDLGLMMREAEAAVLIGDAALRANMLDGP
                     RYGLDVHDLGALWKEWTGLPFVFAVWAARRDYLEREPVITRKVHEAFLASRNLSLQEVD
                     KVAEQAARWEAFDEGTLARYFKTLDFRFGAPQLEAVAEFARRVGPTTGFPADVKVELLQ
                     P"
     gene            6843..7046
                     /locus_tag="BN2145_RS16865"
                     /old_locus_tag="ABM27_RS16595"
     CDS             6843..7046
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014144190.1"
                     /locus_tag="BN2145_RS16865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16595"
                     /product="cold-shock protein"
                     /protein_id="WP_003992177.1"
                     /transl_table=11
                     /translation="MATGTVKWFNAEKGFGFIAQEGGGPDVFVHYSAINASGFRSLEEN
                     QQVSFDVTQGPKGPQAENVTPV"
     gene            complement(7183..7758)
                     /locus_tag="BN2145_RS16870"
                     /old_locus_tag="ABM27_RS16600"
     CDS             complement(7183..7758)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437576.1"
                     /locus_tag="BN2145_RS16870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16600"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_029381080.1"
                     /transl_table=11
                     /translation="MPDDAAALPSRLPLDWIAASLRRERTRAGLSLSELAKRAGIAKST
                     LSQLEAAGGNPSMETIWALAVALGVPFSALVEPPVSSVQVIRAGEGPQVTSERASFVGT
                     LLAACPPGARRDIYRMRAEPGPARESDPHIPGTVEHLVVSTGRMKAGPRGESVELGPGD
                     YMAYRGDVPHTYQALEPGTTFVLIMQHV"
     misc_feature    7822..7835
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.39"
                     /tool="antismash"
     misc_feature    complement(7822..7835)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.91"
                     /tool="antismash"
     gene            7827..8561
                     /locus_tag="BN2145_RS16875"
                     /old_locus_tag="ABM27_RS16605"
     CDS             7827..8561
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437575.1"
                     /locus_tag="BN2145_RS16875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16605"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_029381081.1"
                     /transl_table=11
                     /translation="MRSAQRTSGNSASPPPPPSPARDPELLRDVVLVGLAGGIVGVSFG
                     AISVAGGLPVWVPVVMSLVVYAGSAQFSAVGVLLAGGGPLAAAATGLLLNTRLAAFSLA
                     VAGILGRGWPSRLLGAHLVTDETVAFALAQQDPGRRRAAFWLSGCALFALWNVGVLAGA
                     LAGTALGDTAVYGLDAAFPAVLAALVLPALREDASLRRAALPGAALALAVTPVVPAGVP
                     VLLALAGLLLHRGGARPEGRPA"
     gene            8558..8872
                     /locus_tag="BN2145_RS16880"
                     /old_locus_tag="ABM27_RS16610"
     CDS             8558..8872
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524432.1"
                     /locus_tag="BN2145_RS16880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16610"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_029381082.1"
                     /transl_table=11
                     /translation="MNATVAVILALAAGTYVLRLAGPVLHGRVTLPARVRELLSAGAVV
                     LLVALLATGALTEGGGFAGWARPAGVLAGAVLAWRRAPFAVVVLGAAGVAALLRAVGVE
                     "
     gene            8970..9605
                     /locus_tag="BN2145_RS16885"
                     /old_locus_tag="ABM27_RS16615"
     CDS             8970..9605
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974444.1"
                     /locus_tag="BN2145_RS16885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS16615"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_029381083.1"
                     /transl_table=11
                     /translation="MTDTDHLTATRTFYDAIAEDYAEHFRGQVAGAPQDLEVLAAFARL
                     VGPGAEVADLGCGPGRVTAHLAGLGLRVFGLDLSASMLAVARRENPHLRFEQGSMLELD
                     RPDGSLAGVVSWYSSIHTPAEELPDLFAEFRRVLAPGGHLLLAFQAGDAPLRLDRPFDR
                     PVGLDFQRRRPERMAGLLQDAGFTLHSRTLREPGETESAPQAFLIARR"
     misc_feature    9891..9905
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.21"
                     /tool="antismash"
ORIGIN
        1 tcggcggcgc ctccggcaag gagctggcgg ccacctgcga cagcgcggcg gagctggccg
       61 aggcgtacgg cgcggcgctg gacgcggccg ggtccacgcg ggcggacttc gacatcgagg
      121 gcgacgagct gaccgactcc gcctcggtcg ccctgcggtc gcaggcgatc gcgctgctcc
      181 agcgggaacg gagcggcctg gaggtctcct tcacccttcc ggtgatgccc tccggcctcg
      241 acgccgactc cctggcgctg ctggagtccg ccaacgacca cggcgtccag gtctccacgg
      301 tcaacctcat gaccatgaac tacggcgagt cctggaccgg ggacatgggc gactacgccg
      361 tcacctccgc cgaggccgcc cacacccagc tgcagcgggt cttcggcctg tccgacgcgg
      421 cggcctggaa gggcatggcc ctcacctcga tgatcggcgt caacgatgtc gccggggaga
      481 ccttcaccct ctccgacgcg gcgcaggtgc gcgccttcgc caccgggaag gggatcgcct
      541 gggtgtcggc ctgggcctcc ttccgcgacc ggcggtgcgg cgacgactcg gccggggagg
      601 acgcgtccac cgagtgcagc ggggtggagc aggaggacgg ggcgttcgcc caggcgttct
      661 cggggtgagc ggtacgggcc ccgacgggac ccggcccgtt cagcgccgcc ggtacaccag
      721 gcgccccgcg acgacggtcg ccacgcaggc cgcggccccg cgttcggcga gcgcggcctc
      781 gtcggggacg tcgaagacgg cgaaccgggc cgcggagcca cgctccctcg ggggtgcgaa
      841 cgtcaccggc gcaccgcagg cgtacgggtc gagcgagggc accccgccgg ggcgtccgat
      901 ccggccgacc accgcgagcc cggagcggtg cacggcgtcg cgcaccgcgc ggatgcgcag
      961 ttcgccgcag gccaccgcca ccgtcccgtg gctcagcatg cgttgcagcc cgcgccgggc
     1021 gctggctccc cagcgggcct cgtcgggtgc cagggcggcc agcgcccggc cggtcagcgg
     1081 ttcggtaccc agctcgtcgg cctcgcgcgg gtcggggtgg taggcgccct ccagcagctc
     1141 gtcgccgtac gggttgacga gcccgggggt gaggatgccg ggccaccggc gcagcctggc
     1201 ccccgggcgg gcggcggcga cttcctccag ggggccggcc tcggcgatcc aggcgccttc
     1261 gacggcgagc gcccggcccc tggagtccgc gtggatcgtc agcacgggcg gggtcagttg
     1321 gaggcgagca gcttcagctc ggggtgcgcg gtcccgccct cgatcgccgt ggaggagatg
     1381 tgcgagacca cccggtcgtc gacggggtcg ttcgccgggt cgtcgtggac gacgaggtgc
     1441 tcgtacgtcg tggaccgctg ggccgggacg cggcccgcct tgcggatcag gtcgatgatc
     1501 tccaggcggt tggaccggtg cctggcgccg gccgaggaca ccacgttctc ctccagcatg
     1561 atggagccga ggtcgtcggc gccgtagtgc agggagagct ggccgacctc cttgcccgtg
     1621 gtgagccagg agccctggat gtgggccacg ttgtcgagga acaggcgggc gatcgcgatc
     1681 atccgcaggt actcgaagat ggtcgcctgc gtacggccct tcagatggtt gttctcgggc
     1741 tggtaggtgt acgggatgaa ggcgcggaag ccgcccgtgc ggtcctgtac gtcgcggatc
     1801 atgcgcaggt gctcgatgcg ctcggcgttg gtctcgccgg tgcccatcag catggtggag
     1861 gtcgactcca cgcccagccg gtgcgcgatc tccatgatct ccagccagcg ttcgccggac
     1921 tccttcagcg gcgcgatggc cttgcgcggc cgctcgggca gcagctccgc gccggccccg
     1981 gcgaaggagt cgagcccggc gtcgcggatg cgggtgatcg cctcctcgac gctcaccccg
     2041 gagatccggg ccatgtgctc gacctcgctc gcccccaggc tgtggatgac gagctgcggg
     2101 aactccttct tgatggcggc gaagtgcttc tcgtagtact cgacgccgaa gtcggggtgg
     2161 tggccgccct ggaacatgat ctgcgtaccg cccagttcga cggtctcggc gcagcggcgc
     2221 aggatgtcgt cgaggtcgcg ggtccagccc ttgtcgctct tgggcggggc gtagaaggcg
     2281 cagaacttgc acgccgtgac gcacacgttc gtgtagttga tgttccgctc gatgatgtac
     2341 gtcgcgatgt gctcggtccc ggcgtaccgg cggcggcgta cggcgtcggc ggcggcgccc
     2401 agcgcgtgca gcggggcgtc gcggtacagc gcgagcgcct cgtccggggt gatccgccca
     2461 ccggcggcag cacggtcgag gatgggctga aggtcggcct tctcggtcac cgggcgtccc
     2521 tttcgtaagg gttgtggacg gaccgaacca gcctacgcca gcccttttcc ggggccgacg
     2581 tcaggcgccg ccgagcccgg tccgccggac ccgttcctcg ccgccgcgga ccatggcgct
     2641 ggtgcgctgc ttgggcagcg aggcgctctc gcgggcggtc gtccgggccg gctccccggg
     2701 gtccgggacc ggcatcggcc gcaggcggtg gcgggggatc acccgccggg gcgggcgggt
     2761 cagggtgatc tggcgtacga gctgctggaa gcaggccagg gaggcgagcc ccggcagggt
     2821 cgccgtcgcc gcgtcgacga gcgtgacggg caactgggcg acgcacagga gcatcgccat
     2881 gcaggagaag aagaggacga cggaccagga gtggaccgcg cgccgctggt acagcgcggc
     2941 gcgcagcacg gagagggagg cgaccatcca cggcccgtag accaggaagg gccaccagga
     3001 gaccatgtcg ctcccggtcc gggacgcggc ggaccgcagc agggactcgt acgagaacac
     3061 cccgccgaac acgctgacgg cgcaggcgat ggccgccacc gaggcggcga ggaagtggct
     3121 gaccgcccgg cggccgttga tcctcctggg ctcgcgcacc ttgcggtgcc ccttcgggga
     3181 gtccttcagc gggggcagtt ccgccgtgat ctcctggagg ttgcccaggg gcgtgccggg
     3241 ggcgggggcg gtgaccgacg cctccgggta ggggtcgccc gggggctgct cctccagggc
     3301 gtcccgcagc atgaaggcca gctcttcggc ggggtcccag ttccagtcgg gcggcatcag
     3361 atgaccggtg aacgcttcgg cgggtcgccg gtgccggccg gtgcccatgt cgttggacgt
     3421 ctgcatgttg gtggccgagt gctctcgtcg tgggtcgatt cgtccgtggt acatgacacg
     3481 cggcccgtca ttccgccgac gagagggcgg atgcgtcctg gggggtgccc catcgccggg
     3541 cgggatcgga ttcggattcc agctccgtcg tcaccgtcgg aaaatgccgc ggaatgggtt
     3601 cggtcacctg tagcgtgacg gggagcccgt cccgggtcgg agttctaccg gcagtgcgta
     3661 cggagtgcgc cggggcggga aagtaggtgt acgggcccag catgaccgcg ggccctgtac
     3721 tcctgttccc tcggtgcggg ctggagatca gacccaggag accgtccctg gctgccttcg
     3781 tcatatcccg actaacgccg ccccactcca ccggatgcgc ggcaaatggg tgaacgatta
     3841 cctgtataag taatctcttc gcagggtcgt tcaggcggga tatgcggata gcggaacagc
     3901 ccatctacgc cggtacgagg aacgggaacg ggccgtggcg gcaggcgccg gccagcaccc
     3961 cgagcaaggc cccggcgatc aggaacggcc cgtacgggac ggcggtcccg cgtccgcccc
     4021 gccgcacggc gaccagcgcc cagccgtaca gcgcgccgag caggagaccg gccacggcgc
     4081 ccagcgccag cgtcgcccag ccgtaccagc cgaggacggc gcccgcgccg agggcgagtt
     4141 tcacatcgcc gaagcccatg ccctccgggt tgaggaggaa gagcacgaag tagccgccgc
     4201 cgagggcgag gctgcccagc agggcggtgg tccaccctcc ggcgtgtccc ggcacccgcg
     4261 cggccaggcc gaggagggcg agtgcggcac cggcgagcgg gagggtgagg aggtcgggca
     4321 gccgccgcac ccggaggtcg acggcggcca gcagcacacc ggcgggggcg agcagcagcc
     4381 agacggcgag ttcggggcgg gggccggtgg cggcggcgag ggcggcgcag accaccaggg
     4441 tggcggtggc gaaggcgggg gcgcccggac cgtacgacgg tcccgtcccg gagccgggcg
     4501 gcgctcccgg cggtgcttgg ggcggtgctc cggccgccgc gcacggcccg caccgcgccg
     4561 ggccgagcca gccgcggacc gggtgcccgg ccgggcactc cgtccgccag gattcgtcgg
     4621 gcggtacgga gaaccggtag gcggcgcgcg gcagcagcgc gcccgtcgcc gcgccccaca
     4681 gcgcggcggc gacgacggcc ggcaggacgc tcatcccgct gccgcgccac cgtcgcgccg
     4741 ggtcggcggg gcgggcggga cgcgttcggg cccgccctca cggggccggt gcgggcgggc
     4801 ggtgcggcgt cgcggcatgg cgggcttcct ggcgggtccg gggcgagggg ccggcgggcg
     4861 cgccgagcct actgccccgg caccggacgg ccagggggaa agccgggagc accgcgcacg
     4921 ggcgatggcg tacccggccg gacgccccgg aaaacggcga ggccccggtc cgtgaaggga
     4981 ccggggcctg gcacgactcg tcagagagcg gcgacgtggg cgaccacatc cgccgagaca
     5041 ccctcgacgt tcacaccgac gccgacaccg gcgcacacgg cggcgacggc gtcgacctcc
     5101 gcgaaaacgc ccgcggaagc accggccgcg aggccaccgg cgatgttgtc caggtccgcc
     5161 tcggacatct cggccgtctc aacctggggg gtgaggttca cgacgcacaa ttcccttcgt
     5221 agaaacaaat tgacaacggc ggatctcgcc gaggttcacg aatttctcgg attcccgaac
     5281 ggggctcgtc gccggcgttc cgcgtgccga gatcaaagca cgacgccgga gagacggcca
     5341 gtcaccgggt gtccgtgccc ggattcaccg ggtaaccaat ttcaccagcg tgaggaaaac
     5401 atcaccgaat acccccggtt tccttcacac cgtccggggc cccgcggaac cggcgggcgg
     5461 gtggccggcg atcccggcgc ggacgggtcg tggcaaatcg ggcagcgagt cccgtaattg
     5521 actggcgttc agttcggaga tgaggcaccg gtgaacagtg tgcagatccg tcggattttc
     5581 cgggacggcg gcgaggcggg cgggcggatt cccgcccggg cgggccacca tcggcccccc
     5641 cggctcccgg cgggacccac cgggacccgc ccgctccccc gtcacggctg ggtcacggct
     5701 ggagcagctc caccttcacg tccgccggga agcccgtcgt cgggccgacc cggcgggcga
     5761 actcggcgac cgcctcgagc tgcggggccc cgaagcggaa gtccagggtc ttgaagtacc
     5821 gggcgagggt cccctcgtcg aacgcctccc agcgggccgc ctgctcggcg accttgtcga
     5881 cctcctggag ggagaggttg cgcgaggcga ggaacgcctc gtgcaccttg cgcgtgatga
     5941 ccggctcgcg ctccaggtag tcgcgccggg ccgcccagac cgcgaagacg aacggcaggc
     6001 ccgtccactc cttccacagc gcgcccaggt cgtgcacgtc caggccgtag cgcgggccgt
     6061 cgagcatgtt ggcgcgcagc gccgcgtcgc cgatcaggac ggccgcctcg gcctcccgca
     6121 tcatcaggcc caggtcgggc gggcaggtgt agtagtcggg ccgtacgccg atccgctcct
     6181 ccagcagcag ccgggcgagc cggacggagg tgcgcgaggt cgagcccagc gcgacccggg
     6241 cgccgtccag gcgctccagc gggacctgcg agacgatcac gcacgacatc accgggccgt
     6301 cgcagccgac ggcgatgtcg gggaaggcga cgagccggtc ggcgtgcttg aggaactcga
     6361 ccagggtgat cggcccgatg tcgaggtccc cccgcacgag ctgctcgctg agcttctccg
     6421 gggtgtcctt ggtcagctcg aagtcgagga gcgtgcccgt tctcgcgagc ccccagtaca
     6481 ggggcaggca gttcaggaac tggatgtggc cgacacgcgg ccgggtgcga gaattgtcca
     6541 catcgcgagg ctagccctcg tcccccgcgg tccggcgccg gcccggcagc ggcccggccg
     6601 tccgccgggc gggtggaacg ttcaaacatt cgggtgacgt gatcttgacc tctattgctt
     6661 tccggtgccc gcgtgctacg ctcacagcaa gttgcagttt ggtttccctt gcagtacaga
     6721 gcctgcggag catgtgaccg cgggctctcg tcgttcttgg acgtatgcag ttgtgcagaa
     6781 ttcaactctt cacacttgct ggttctggag cagggcaacc cttttgagcc caaggagggc
     6841 ttatggctac cggaaccgtt aagtggttca acgccgaaaa gggctttggt ttcatcgccc
     6901 aggagggcgg cggccccgac gtcttcgtcc actactccgc gatcaacgcg tccggtttcc
     6961 ggtcgcttga ggagaaccag caggtgtcct tcgacgtcac gcagggtccg aagggcccgc
     7021 aggctgagaa cgtcaccccg gtctgataag cagtacccaa ggagccccgc gccgttccgg
     7081 cgacggggct cctgcccttt cccgccgctt tccggggccg ccccgtccgc ttccggcccg
     7141 tccctcgggc cgccgccccg gtgaattccc ggcgaattct tctcatacgt gctgcatgat
     7201 cagtacgaac gtcgtccccg gttccagcgc ttggtaggtg tgcggcacat ctccgcgata
     7261 cgccatgtag tccccgggcc ccagctctac gctctcgccc cgaggccccg ccttcatccg
     7321 tcccgtactg acgacgagat gctcgaccgt ccccggaatg tgcgggtccg attcccgtgc
     7381 cgggcccggc tcggcccgca tgcggtagat gtcccgccgg gcgccgggcg ggcaggcggc
     7441 cagcagcgtg ccgacgaagc tcgcccgttc cgacgtgacc tggggcccct ccccggcccg
     7501 gatcacctgg accgacgaca ccggcggctc caccagggcg ctgaacggca cccccagcgc
     7561 caccgcgagc gcccagatgg tctccatgct cgggttgccg cccgccgcct ccagctgcga
     7621 cagggtggac ttggcgatgc cggcccgctt ggccagctcg gacagcgaca gcccggcccg
     7681 ggtccgttcg cggcgcaggg aggcggcgat ccagtcgagg ggcaggcggg acgggagggc
     7741 ggcggcgtca tccggcatgt cgttcgctcc atcggtacga tcgttcgtct tgacgaacag
     7801 gggtctcgct gtccatcgta gaaaacatgc gttcggcaca gcgaacaagc gggaactccg
     7861 cctccccgcc gcctcctccc tcgcccgccc gtgatcccga gcttctccgg gacgtcgtcc
     7921 tcgtcggtct cgccggtggg atcgtcggcg tgtcgttcgg cgccatctcc gtcgcgggcg
     7981 ggctgccggt gtgggtgccc gtggtgatgt cactggtggt gtacgcgggt tcggcccagt
     8041 tcagcgcggt cggcgtgctg ctcgccgggg gcggtccgct cgccgcggcg gcgacgggcc
     8101 tgctgctcaa cacccggctg gcggccttca gcctggcagt cgccgggatt ctcggccggg
     8161 gatggccgtc gcggctgctg ggagcccatc tggtcaccga cgagacggtg gcgttcgcgc
     8221 tcgcccagca ggacccgggg cgccgccggg cggcgttctg gctctccggc tgcgcgctgt
     8281 tcgcgctgtg gaacgtgggc gtcctggccg gggcgctggc cggtaccgcc ctcggcgaca
     8341 cggccgtcta cggtctggac gccgccttcc ccgccgtcct ggccgccctg gtgctccctg
     8401 cgctccgcga ggacgcaagc ctgcgccggg ccgccctgcc cggtgccgcg ctggcgctgg
     8461 cggtgacccc ggtcgtcccg gcgggggtgc cggtgctgct ggcgctggcg gggctcctcc
     8521 tccaccgcgg tggcgcccgg cccgaggggc ggcctgcgtg aacgcgacgg tggcggtgat
     8581 cctggcgctg gcggccggga cgtacgtcct gcggctggcc ggcccggtgc tgcacggccg
     8641 ggtcaccctc ccggcgcggg tgcgggagct gctgtccgcc ggggcggtgg tgctgctggt
     8701 cgcgctgctg gccaccgggg cgctgaccga gggcgggggc ttcgcgggct gggcgcgtcc
     8761 ggccggggtg ctggcggggg ccgtactggc ctggcggcgg gcgccgttcg cggtcgtcgt
     8821 cctgggcgcg gcgggcgtgg cggcgctgct gcgggcggtg ggggtggagt gaggacggaa
     8881 atgagtaccc ggcccggccg tcggtggcgg ccggggggtg ggcgggggcg cggcccggct
     8941 gtcggtggcg gccggtaggg tccgcgccca tgaccgacac cgatcacctc accgccaccc
     9001 gcaccttcta cgacgccatc gccgaggact acgccgagca cttccgcggt caggtggccg
     9061 gcgcgcccca ggacctggag gtgctcgccg ccttcgcccg gctcgtcgga ccgggggccg
     9121 aggtcgccga cctgggctgc gggcccggcc gggtgaccgc tcacctggcc gggctggggc
     9181 tgcgcgtctt cggcctggac ctgtccgcct cgatgctcgc cgtcgcccgc cgcgagaacc
     9241 cgcacctgcg cttcgaacag ggctcgatgc tggagctgga ccggccggac gggtcactgg
     9301 cgggcgtggt ctcctggtac tccagcattc acaccccggc ggaggaactc ccggacctgt
     9361 tcgccgagtt ccggcgggtg ctggcgcccg gcgggcatct gctgctcgcc ttccaggccg
     9421 gtgacgcgcc gctccgcctc gaccggccct tcgaccgccc ggtcggcctc gacttccagc
     9481 ggcggcggcc ggagcgcatg gccgggctgc ttcaggacgc cggtttcacc cttcactcgc
     9541 ggacgctgcg ggaaccgggc gagacggagt cggctccgca ggctttcctg atcgcccgcc
     9601 gctgagctcg ggcaccaggg tggccaggcc caccagggcc agggcggcgc ccagccagag
     9661 gggagcgcgc aggccccaca cgtcgatccc gacggccccg agcgaggagc cgacgatgat
     9721 gccgagggtg atgaaggagg agtggacggt gttcaccagc gggccggcgt tgccggtccg
     9781 ctggacccgg gtgatcatcg ccgggttcat ggtcacgccg accaggccga tgcccagcat
     9841 gcacagcacg gccggtgccg gcagatcggc gaggagggcg aagcccgcca ggaacatcgt
     9901 gttcaggacc agaccggcgg ccaggaccgg gacggcgtac cggtcggcga ggcggccgac
     9961 gacggtgttg ccgaccacgg tggcggcgcc gtaggcgatg agcagcaggg ggacggtgcc
    10021 cgcggagaag ccggtgacct ccgtgaggat cgggttgagg tagctgaagg cggagaaggt
    10081 ggcgccgatg accagcatgc tggtggagag caccagccac agcttcgggt tgcggaagac
    10141 accgatctcc tgccggaagc cgccctcgct cgcggcggct tccaggcgcg gcacgcccac
    10201 c
//
