LOCUS       NZ_LN831790            22167 bp    DNA     linear   CON 08-APR-2024
DEFINITION  Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 =
            NRRL B-24963) chromosome 1.
ACCESSION   NZ_LN831790
VERSION     NZ_LN831790.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Gomez-Escribano,P.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2015) JIC, Department of Molecular Microbiology,
            Norwich Research Park, Norwich, NR4 7UH, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001013905.1-RS_2024_04_08
            Annotation Date                   :: 04/08/2024 03:45:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,096
            CDSs (total)                      :: 7,005
            Genes (coding)                    :: 6,806
            CDSs (with protein)               :: 6,806
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 82 of 199
            Pseudo Genes (incomplete)         :: 160 of 199
            Pseudo Genes (internal stop)      :: 10 of 199
            Pseudo Genes (multiple problems)  :: 49 of 199
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:33:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1624096
            Orig. end                         :: 1646263
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN831790.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22167
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="13"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22167
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22167
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12167](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12167)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            578..1396
                     /gene="pssA"
                     /locus_tag="BN2145_RS07800"
                     /old_locus_tag="ABM27_RS07680"
     CDS             578..1396
                     /EC_number="2.7.8.8"
                     /GO_function="GO:0003882 - CDP-diacylglycerol-serine
                     O-phosphatidyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pssA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387957.1"
                     /locus_tag="BN2145_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07680"
                     /product="CDP-diacylglycerol--serine
                     O-phosphatidyltransferase"
                     /protein_id="WP_029381222.1"
                     /transl_table=11
                     /translation="MPEAAEADDEEEMPLSLRLSIADTLTLGNATCGFMAVYFTTTGIL
                     IPHLSGSQETGMARHSAATAVILMLCAAVFDLFDGLVARKLRSSPMGAELDNLSDLISF
                     GLAPAYFVLVYGMVADDAHQRVAAVGAIVVLLAVVLRLARFSCVTVKDGTFQGMPSPFG
                     ALTVVSIVLLELPFVATVLAVLGTAWLMVSRVEYPKPRGRLAVAMLSWIVLSMGLLAAW
                     AFDAPSGQLLLQTGCALQLVMGAVIPLFATARRVNNFRGNRREARAAQLP"
     gene            complement(1609..2745)
                     /locus_tag="BN2145_RS07805"
                     /old_locus_tag="ABM27_RS07685"
     CDS             complement(1609..2745)
                     /EC_number="2.7.1.31"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008887 - glycerate kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983357.1"
                     /locus_tag="BN2145_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07685"
                     /product="glycerate kinase"
                     /protein_id="WP_029381221.1"
                     /transl_table=11
                     /translation="MDGARGVLVAADKFKGSLTAVEVAERVTAGLRRVAPGVRVEALPV
                     ADGGDGTVAAAVAAGFERREVRVAGPLGDEVTAAFALRGDTAVVEMAEASGLQRLPAGV
                     LAPLTASTHGSGELLRAALDAGARTIVFGVGGSATTDGGAGMLAALGARFLDAGGKPVG
                     PGGGGLADLATADLSGLDPRLASVELVLASDVDNPLTGPKGAPAVYGPQKGASPDDVET
                     LDAALTHYAKVLEDTVGAKAAEYAASPGAGAAGGIGYGALLLGARFRPGIEVMLDVLGF
                     APALERAELVITGEGSLDEQTLHGKAPAGVAAAARAAGKEVVAVCGRLALPAETLGRAG
                     IRRAYPLTEIEPDVEKCIAQAGPILERVAENIARDFLV"
     gene            2905..3978
                     /locus_tag="BN2145_RS07810"
                     /old_locus_tag="ABM27_RS07690"
     CDS             2905..3978
                     /EC_number="3.2.2.-"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994079.1"
                     /locus_tag="BN2145_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07690"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_029381220.1"
                     /transl_table=11
                     /translation="MTSVNGQPRLADRVLGGWLGRIAGNMLGKPVEQGEVWTRDRIDRY
                     LREAGALPLTDYLPEPAGDSDRLALRPEWRGCVRGRIHGSCRDDDVDYAVLGLHLLETH
                     GFGFTTEQVGDLWLLRLPYLQTFTAERAAYRNLANGLKPPLTATYDNPYQEWIGALIRA
                     DIHGWTCPGAPGRAALLARRDAVLSHTGNGVYGAMWAAALISAAFTAPTVREAVEQALA
                     VIPASSRLARTVRRVASLHDAGLTWEETLATVSEETAGLGWIHTVPNAAVLTAGLLYGD
                     GDFTRTITLTVRGGLDTDSNGATAGSVAGVFGGASAIPAQWTDPLRDTVRSAVFGFDGV
                     RISELAERTLRLAGAPA"
     gene            complement(4039..4359)
                     /gene="fdxA"
                     /locus_tag="BN2145_RS07815"
                     /old_locus_tag="ABM27_RS07695"
     CDS             complement(4039..4359)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950253.1"
                     /locus_tag="BN2145_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07695"
                     /product="ferredoxin"
                     /protein_id="WP_029381219.1"
                     /transl_table=11
                     /translation="MTYVIAQPCVDVKDKACIQECPVDCIYEGQRALYIHPEECVDCGA
                     CEPVCPVEAIFYEDDTPQEWAQYKAVNAEFFDELGSPGGASAHGLIERDHPVVAGQPVR
                     TG"
     gene            complement(4537..5688)
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="BN2145_RS07820"
                     /old_locus_tag="ABM27_RS07700"
     CDS             complement(4537..5688)
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431355.1"
                     /locus_tag="BN2145_RS07820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07700"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_047121608.1"
                     /transl_table=11
                     /translation="MPVALGVPTVPPRPAPRRRSRRIQVGSVAVGGDAPVSVQSMTTTR
                     TSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYVFA
                     AIEAGCAAVRVNPGNIKKFDDQVREIARAAKDHGTPIRIGVNAGSLDKRLLQKYGKATP
                     EALVESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAEACDYPLHLGVTEAGPA
                     FQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEVKVGIQILQALGLKERRLEIVSCPS
                     CGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFV
                     KGEVVKTVPESRIVETLIEEAMRIAEQTPRDEADAEGAPAAGG"
     gene            complement(5710..7509)
                     /locus_tag="BN2145_RS07825"
                     /old_locus_tag="ABM27_RS07705"
     CDS             complement(5710..7509)
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566812.1"
                     /locus_tag="BN2145_RS07825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07705"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_029385668.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 1.1e-81,
                     bitscore: 272.7, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.3e-06, bitscore:
                     25.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRLGEIRGPEDLRALTPRQVRALAPQIRRLLVDTCTVTGGHLGP
                     NLGVVELTLALHRVFHSPRDRILWDTGHQTYVHKMLTGRTEDFPTLRRAGGLSGYPSRA
                     ESEHDVIENSHASTVLSWADGLARAHALRGVTDRAVVAVLGDGALTGGMAWEALNNIAA
                     APERPVIVVLNDNGRSYAPTAGALATHLAALRGPDAPRPLFESLGMAYLGPVDGHDIEA
                     LETALRRAAGLGRPVVVHCLTEKGRGHLPAEQDETDRFHAVRAASAKKPGGAPSWTSVF
                     GRELADLAADRPDVVALTAAMLDPTGLSEFARRHPERTIDVGIAEQHAVTAAAGLALGG
                     MHPVVALYATFLNRAFDQLLMDVALHRAPVTFVLDRAGVTGDDGPSHNGMWDLSLLNLV
                     PGLRLAVPRDAATLRRALREALSCHDGPTALRFPKGTSGEDIPAVTTFAGIDVLRRGER
                     PDLLLVSVGAMAATCLDVAGRLAAQGVGVTVVDPRWVKPVAPELVALALEHRLVATVED
                     NGRAGGVGTQIAQALSDAGAAPPVRTFGIPQHFLNHGSRAQVLEAGGLTARHLTRALLE
                     SLPAGRDAAREEAATPSLALGGR"
     gene            complement(7539..8540)
                     /locus_tag="BN2145_RS07830"
                     /old_locus_tag="ABM27_RS07710"
     CDS             complement(7539..8540)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358319.1"
                     /locus_tag="BN2145_RS07830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07710"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_029385667.1"
                     /transl_table=11
                     /translation="MTAGSVVLAQPRGFCAGVRRAIGIVERALDLYGAPVYVRKEIVHN
                     HYIVSELVKRGAVFVDSEEEVPEGAVCVFSAHGVSPGVRTAAAGRGLEVIDATCPLVSK
                     VHQEAVRFARDGRTILLVGHEGHEEVEGVLGEAPDRIVVVETEEDVRRLGLPDDTPVAV
                     LTQTTLSFDETAKVVEALRARFTDLLTPGDDDICYASQNRQNAVKDLARRNDLVLVVGS
                     RNSSNSLRMVEVAREHGAAAHLVPDETHLDEAWLEGVSAIGVSAGASAPEILVHGLVTR
                     LAALGYDRVELQRGIAEDVVFSMPGRLADPVTGRVPRTPLAGEAPLSPGGAA"
     gene            complement(8537..9931)
                     /gene="ptlI"
                     /gene_synonym="penI; pntI"
                     /locus_tag="BN2145_RS07835"
                     /old_locus_tag="ABM27_RS07715"
     CDS             complement(8537..9931)
                     /EC_number="1.14.15.32"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0050467 - pentalenene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000060: Oxidation (88% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penI; pntI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358320.1"
                     /locus_tag="BN2145_RS07835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07715"
                     /product="pentalenene oxygenase"
                     /protein_id="WP_029385665.1"
                     /sec_met_domain="p450 (E-value: 8e-77, bitscore: 257.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEQTTFVAGAAPGAVPVVGHALQMMRHPVNFMTSLSAHGDLVQI
                     KIGPTSAYVPTHPDLLRYVLTNDRIFDKGGVFYDRARDIAGNGLVTCPFADHRRQRRLM
                     QSAFTRTQLKRYATAMHAEIEATTARWHDGMVVDAFPELYGMALRTVGRTLYSTPVSPE
                     LAAGVERAFDVVLNGLFRQMFLPRFIRRLPLPANRRYESNLRFLHRTTQELIDDYRSDG
                     AAHDDLLAALLASRDDDGGRLDDKEIHDQVITVMAAGTETVAGTLTWVFYLLSQHPEIE
                     AALYEEIDTVLGGRAPDWDDLPNLSLADRIISEALRLHPPAWLFTRLTATETELAGRRL
                     PEGTTIVFSPAAVAQYEDAFGNPTAFDPDRWLPDRVSPAARQAFMPFGTGARKCIGDLY
                     ARTEATLGLATILGRWRVTCEPDMDVRPVPLATVYHPRRLRLRLSARTPRPAATPVPAP
                     AGGDPA"
     misc_feature    9925..9938
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.57"
                     /tool="antismash"
     gene            complement(10001..11014)
                     /gene="ptlA"
                     /gene_synonym="penA; pntA"
                     /locus_tag="BN2145_RS07840"
                     /old_locus_tag="ABM27_RS07720"
     CDS             complement(10001..11014)
                     /EC_number="4.2.3.7"
                     /GO_function="GO:0050467 - pentalenene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /gene_synonym="penA; pntA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358321.1"
                     /locus_tag="BN2145_RS07840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07720"
                     /product="pentalenene synthase"
                     /protein_id="WP_029385660.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-80, bitscore: 269.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFHIPLPARQSPDHARADAEQLAWPRSLGLIKSEAAARRH
                     LRGGYADLASRFYPHAIGADLDLGVDLMSWFFLFDDLFDGPRGENPEETKQLTDAVAAA
                     LDGPLPDTAPPIAHGFADIWRRTSEGMTPAWCARSARHWRSYLGGYVDEAESRFRDRPY
                     DSAAQYLAVRRQTIGVQPTVDLAERAGRFEVPHRVFDSAVLSAMLQIAIDVNLMLNDIA
                     SLEKEEARGERNNMVMILRREHGWSESRSISHIQQEVHARLEQFLLLESCLPKVADIYR
                     LDEAEREALERYRTDAVRTVIRGSYDWHRSSGRYDAEFALAVGSQGYLEELGSTAR"
     gene            complement(11154..12167)
                     /locus_tag="BN2145_RS07845"
                     /old_locus_tag="ABM27_RS07725"
     CDS             complement(11154..12167)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182243.1"
                     /locus_tag="BN2145_RS07845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07725"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_029385659.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.7e-60, bitscore:
                     202.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPACLGHSRVTITPALRAAVDRLDHRSRHQAAYHFGWITAGG
                     APTSADSGKAVRPALALLSAEAVGAPAEVALPGAVAVELVHNFSLLHDDLMDGDEERRH
                     RRTVWKLWGPSSAILTGDALLALAQEVLLDTGLPTAAPAARLLARTTRHLIRGQVQDLA
                     FEQRSYVTVEECIDMAAGKTGALMSASAAIGAVLAGAPEATVDALALYGDQVGVAFQLV
                     DDVLGIWGDPAVTGKPVHSDLRSRKKSLPVSHALNRGGPLGDELAAWLTTPGEPHEEEL
                     RRVAGLIETAGGRDWALAEAARRMALAEDALRGAELHAAARDELLALGRFVVDREV"
     gene            complement(12164..13063)
                     /gene="ptlD"
                     /gene_synonym="penD; pntD"
                     /locus_tag="BN2145_RS07850"
                     /old_locus_tag="ABM27_RS07730"
     CDS             complement(12164..13063)
                     /EC_number="1.14.11.-"
                     /EC_number="1.14.11.36"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (5-281). E-value: 1.2e-54. Score:
                     177.8. Matches aSDomain:
                     nrpspksdomains_BN2145_RS07850_TauD.1"
                     /codon_start=1
                     /gene="ptlD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000058: Dehydration, Oxidation (86% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penD; pntD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182242.1"
                     /locus_tag="BN2145_RS07850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07730"
                     /product="neopentalenolactone/pentalenolactone F synthase"
                     /protein_id="WP_029385658.1"
                     /sec_met_domain="TauD (E-value: 1.3e-52, bitscore: 177.8,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVTPIPGAALGAVVRGAQVTGDMDKTQVEQIWAALDAHLVLVFR
                     GHETPSYEEFLAFGRRFGYIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAEWMGW
                     HTDYSFRPCVSQVGFLEAVEVPSSGGGETLFTDMYALYESLSNEERRRLHTYRVRHALR
                     TGYEDTIEEELQGEVSLGESTERIQPEDGTSTIHPLIARNPRTGRQSVYVSTLNTKRIV
                     DLAPDDSRKLLDELLSHAGKPQYTYTHTWQPGDIVMWDQLGTVHAKQPFDPAERRIMRQ
                     VVSIFDDPTDPWHAEVAA"
     aSDomain        complement(12221..13048)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN2145_RS07850_TauD.1"
                     /evalue="1.20E-54"
                     /label="BN2145_RS07850_TauD.1"
                     /locus_tag="BN2145_RS07850"
                     /protein_end="281"
                     /protein_start="5"
                     /score="177.8"
                     /tool="antismash"
                     /translation="IPGAALGAVVRGAQVTGDMDKTQVEQIWAALDAHLVLVFRGHETP
                     SYEEFLAFGRRFGYIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAEWMGWHTDYS
                     FRPCVSQVGFLEAVEVPSSGGGETLFTDMYALYESLSNEERRRLHTYRVRHALRTGYED
                     TIEEELQGEVSLGESTERIQPEDGTSTIHPLIARNPRTGRQSVYVSTLNTKRIVDLAPD
                     DSRKLLDELLSHAGKPQYTYTHTWQPGDIVMWDQLGTVHAKQPFDPAERRIMRQ"
     gene            complement(13098..14909)
                     /gene="ptlE"
                     /gene_synonym="penE; pntE"
                     /locus_tag="BN2145_RS07855"
                     /old_locus_tag="ABM27_RS07735"
     CDS             complement(13098..14909)
                     /EC_number="1.14.13.170"
                     /EC_number="1.14.13.171"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlE"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000057: Oxidation (92% identity)"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penE; pntE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358324.1"
                     /locus_tag="BN2145_RS07855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07735"
                     /product="neopentalenolactone/pentalenolactone D synthase"
                     /protein_id="WP_242513950.1"
                     /transl_table=11
                     /translation="MARAESDDRDETLTIDLEAVREKYRQERDKRSVGRTYQFARGDFS
                     RYARDPYTERQEREPLTDEVDVAVVGAGIGGLLTGAHLRMETGLERIRLIDEAGDVGGT
                     WYWNRFPGVRCDVESYIYMPLLEEIGTIPTEKYSTGPEIFAHLQKIAHKYDLYRDALFQ
                     TAVTELRWDEAAGRWLVSTDRGDRFRARYVAMSIGLMHRPKLPKLPGLETFAGHSFHTS
                     RWDFDYTGGDSTGGLTKLKDKTVGVIGTGSTTVQLAPHLAEWAEQLVIFQRTPAAVDVR
                     GNRPTPPDWADSLEPGWQQRRMENFHALTSGVPQDEDLVQDRWTQTTAKLAAAILPTGD
                     TGGDPKERALAAERADFLKMEELRARIDSVVTDPATAAALKPYYRVYCKRPCFHDSYLQ
                     TFNRPNVTLVDTQGQGVERLTRTGVVANGREYPVDCLVFATGYEHEFSVPYTDRAGYDI
                     IGRDGLKLSEKWADGARTLHGLQVNGFPNCFILSKIQAGRHVNIAYMLSEQTRHLAYIV
                     KSVEERGHRVVEASEAGEKEWVEEILRLASNDIDFLENCTPGLYNNEGDPSSLPLLNSS
                     YGGGSVEFVNILRRWREAGDLAGLELR"
     gene            complement(14870..15694)
                     /gene="ptlF"
                     /gene_synonym="penF; pntF"
                     /locus_tag="BN2145_RS07860"
                     /old_locus_tag="ABM27_RS07740"
     CDS             complement(14870..15694)
                     /EC_number="1.1.1.340"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-177). E-value: 1.3e-11. Score:
                     36.7. Matches aSDomain:
                     nrpspksdomains_BN2145_RS07860_PKS_KR.1"
                     /codon_start=1
                     /gene="ptlF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penF; pntF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182240.1"
                     /locus_tag="BN2145_RS07860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07740"
                     /product="1-deoxy-11-beta-hydroxypentalenate dehydrogenase"
                     /protein_id="WP_029385656.1"
                     /sec_met_domain="adh_short (E-value: 5e-30, bitscore:
                     103.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFRTRTAVVTGAASGIGLALSARFARAGARVVMADVADDALHRR
                     AAELTAQDAQVTAVTADLTDPDAVEQLADTAFGLLGDVDVVCNNAGVLGPVGQPLWEVP
                     LERMRQVFEVNHWAHVLVARAFVPRLLERGRPAHLIHTASMSAFVVGAGSAAYAASKHA
                     DLAVARSLRADLRGTGIRVSVLCPGRVDTPMVQGLTAPRGAGGDTSVSAEDVAGLVWEA
                     LGTDRFYLFSNADAPQRLRDQFDDVWRDISLPPPSPEEEPWPAPKATTAMKP"
     aSDomain        complement(15164..15676)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN2145_RS07860_PKS_KR.1"
                     /evalue="1.30E-11"
                     /label="BN2145_RS07860_PKS_KR.1"
                     /locus_tag="BN2145_RS07860"
                     /protein_end="177"
                     /protein_start="6"
                     /score="36.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAASGIGLALSARFARAGARVVMADVADDALHRRAAELTA
                     QDAQVTAVTADLTDPDAVEQLADTAFGLLGDVDVVCNNAGVLGPVGQPLWEVPLERMRQ
                     VFEVNHWAHVLVARAFVPRLLERGRPAHLIHTASMSAFVVGAGSAAYAASKHADLAVAR
                     SLRADLRG"
     CDS_motif       complement(15602..15670)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN2145_RS07860_0001"
                     /evalue="2.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN2145_RS07860"
                     /protein_end="31"
                     /protein_start="8"
                     /score="16.7"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARFARAGAR"
     gene            complement(15795..17249)
                     /locus_tag="BN2145_RS07865"
                     /old_locus_tag="ABM27_RS07745"
     CDS             complement(15795..17249)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182239.1"
                     /locus_tag="BN2145_RS07865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07745"
                     /product="MFS transporter"
                     /protein_id="WP_029385655.1"
                     /transl_table=11
                     /translation="MTKREGLPPLKESDATPQPSAGTEPAAAGLSGIGLVVVLVGYALS
                     IVDASIVNVALTSISDDLHGGPAALELVVSGYGLTYALGLVLGGRLGDAFGRRRLYAYG
                     LAAFTATSALCGLAPTIEFLVVARLLQGAAAAMLVPQVLATIQAATEGQARARAIGRYG
                     ATAALGMVVGQILGGLLVSLDVAGMGWRSVFAINVPIGVAALLAVRRVPATKADTKPGF
                     DPAGTALFGVTMVCVLAVVVAGPDLGWPLWLWSLLAVAAVGALALVRTERALEARGGSP
                     LLSPSVLSHPGMRRGLAAMVPFSAGFGAFLFVYALIAQGHFGLDGLASGGVLTPFAVAF
                     FAVTLFTPRIAAALGGRIVTLGALVQGIGLLLLALVIWLGWPRPSLGLVLVGIGLFGVG
                     AALTGPTLFRMILADVPRAQAGMGSGVLVTSQQMATALGATVGGTLYVSLDGWLSTASA
                     AVLVLALLTCFAVTVLVISLKLPDPS"
     gene            complement(17308..18159)
                     /gene="ptlH"
                     /gene_synonym="penH; pntH"
                     /locus_tag="BN2145_RS07870"
                     /old_locus_tag="ABM27_RS07750"
     CDS             complement(17308..18159)
                     /EC_number="1.14.11.35"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penH; pntH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182238.1"
                     /locus_tag="BN2145_RS07870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07750"
                     /product="1-deoxypentalenic acid 11-beta-hydroxylase"
                     /protein_id="WP_029385654.1"
                     /sec_met_domain="PhyH (E-value: 2.2e-17, bitscore: 62.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETFSDYVDCTPLLDDREAIDRFYDEHGYLYLRGALDRDLVRTA
                     AEQMLEGLIALGHAAPGTTLDTLTIESFEAVDEVAMHDYVKYDDLWNHPSTLKVWEKVF
                     GEPVFVFKSTTIRYYPSAAGSAEPSFLTPLHQDGFYIGPNKDFRTAWVPLLPTTRDIGG
                     VAVADGSHKKGPREHVVTENFRRFGHPVRGIPPEQLGADEPLLFSPMQPGDVILFHAFM
                     CHKSIPNVSANPAGMRMSMDTRIQPASSHRGFNALTPWPESAKDPSKGVMSKITGTPAT
                     VE"
     gene            complement(18409..19605)
                     /gene="penM"
                     /gene_synonym="pntM"
                     /locus_tag="BN2145_RS07875"
                     /old_locus_tag="ABM27_RS07755"
     CDS             complement(18409..19605)
                     /EC_number="1.14.19.8"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016636 - oxidoreductase activity, acting
                     on the CH-CH group of donors, iron-sulfur protein as
                     acceptor [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="penM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000059: Other (87% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="pntM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182237.1"
                     /locus_tag="BN2145_RS07875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07755"
                     /product="pentalenolactone synthase"
                     /protein_id="WP_029385653.1"
                     /sec_met_domain="p450 (E-value: 2e-18, bitscore: 65.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELPRLPFDNPDIIGIAPQMFALQKEGPIARVRTAGEDAWLVTR
                     YDEVRTLLADRRLALSNPYPERTTKSAARAFMVALMAGDDYHTEAPRHAQMRALLVPRF
                     STRRMRLMKSRIEQHVDELLDELAASTPPVDLHRALSFPLPTMVVCDLLGVPLADRERF
                     GQWARGTFDQSDNQHSANTFQQVVDYMTELVARKRIEPGDDILSELIADKDHALSDAEI
                     AHLGNAVLLFGYETTIVRIDLGTLLLLRNPAQRALLVEKPELAPAAVEEILRLGVGGNG
                     SNAIIPRYAHSDITVGDTVIRAGDAVMLAIGAANYDERAYPGADLFDLTREKPKSHMAF
                     GHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEETLRWQEHRITGGFDEIPVTF"
     misc_feature    complement(19585..19587)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19614..19629)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            complement(20079..21089)
                     /gene="gap"
                     /locus_tag="BN2145_RS07880"
                     /old_locus_tag="ABM27_RS07760"
     CDS             complement(20079..21089)
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0019682 - glyceraldehyde-3-phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173542.1"
                     /locus_tag="BN2145_RS07880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07760"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_029385652.1"
                     /transl_table=11
                     /translation="MTITVGINGFGRIGRSYFRALLASGADIRVAAVNDLTDAKALANL
                     LKYDSVYGPLPQEVVAEGSSLRVGDTVVEVLGERDPAQLPWGRLGVDVVIESTGVFNDA
                     AKARKHIDAGASKVVVSAAAKNADLTLVYGVNDNLYDPEKHTIVSNASCTTNCLAPMAR
                     VLDDALGIECGTMTTIHAYTQDQNLQDGPHADPRRARAANLSTIPTTTNAASAIGLVLP
                     SLQGKLDGFSVRVPVPVGSLTDLTVRVGRETSVEEVNSLFRKAADGDLARILRYTADPV
                     VSADIVRDPASCIFDSLLTQVIDGRHVHVFGWYDNEWGFSNRLIDTTKLVAGVTE"
     gene            21424..21885
                     /locus_tag="BN2145_RS07885"
                     /old_locus_tag="ABM27_RS07765"
     CDS             21424..21885
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357668.1"
                     /locus_tag="BN2145_RS07885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07765"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_029385651.1"
                     /transl_table=11
                     /translation="MTSTQRVPLHDDLDVGDLTQAIENFNRYYIRLPTVQKLSFTTLSV
                     LDTLAHGGPKRLTELARTEQISQPGLTQLVTRLERDGLVERRPDPTDGRAVLVHITDRG
                     RKIGQARHEDRGRHLLPVIARLTPAERRAIAAALPALSRLAELGTQAGR"
     gene            complement(21958..22158)
                     /locus_tag="BN2145_RS07890"
                     /old_locus_tag="ABM27_RS07770"
     CDS             complement(21958..22158)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133221.1"
                     /locus_tag="BN2145_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS07770"
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_029385649.1"
                     /transl_table=11
                     /translation="MAKVTVSLDAQLVVEVMVLAGVGNPQDAVELVVRDYIARGHRTEA
                     KIAERDEALREIDAGPRTNEG"
ORIGIN
        1 ctcagcctgg cccgggcgcg ccgttccggc gccgccaagg ccatcgccgt ccccgccacc
       61 gcgctcgcgg cggggatgct gtggttcttc cgcgaccccg agcgcgagat cgcccagggc
      121 cgggtcatct cgccggccga cggcgtggtg cagagcatca tgccgtggaa ggacggccgc
      181 acccgcgtcg cgatcttcat gagcccgctc aacgtacacg tcaaccgcgc cccgctggcc
      241 ggcacggtga cctcggtgga gcacatcccc ggcggtttcg ttcccgcttt caacaaggag
      301 agcgagaaca acgagcgggt cgtctggcac ttcgacaccg agctcggtga catcgagatg
      361 atccagatcg ccggagcggt ggcccgccgc atcgtcccct acgtgcccga gggcaccaag
      421 gtcgagcagg gtgagcggat cggcctgatc cggttcggct cgcgcgtcga cctctacctg
      481 cccgagggcg tggaggtcgc ggtcgaggtc ggacagaaga ccgtggctgg ggtgactcgc
      541 attgaccgtg attgatccgg agacccaggc gggctgggtg cccgaggccg ccgaggcgga
      601 cgacgaggag gagatgcccc tctcgctccg tctgtcgata gcggacaccc tcaccctggg
      661 caacgccacg tgcggcttca tggcggtgta cttcaccacc accggcatcc tgatcccgca
      721 cctgtcgggc agccaggaga ccggcatggc ccggcacagc gcggccaccg cggtcatcct
      781 gatgctgtgc gcggcggtct tcgacctgtt cgacggcctg gtggcgcgca agctgcgcag
      841 ctcgccgatg ggcgcggagc tggacaacct ctccgacctg atcagcttcg gcctggcccc
      901 ggcgtacttc gtcctggtgt acggcatggt ggcggacgac gcccaccagc gggtggcggc
      961 ggtcggcgcg atcgtcgtcc tgctggcggt ggtgctgaga ctcgccagat tctcctgcgt
     1021 cacggtcaag gacgggacgt tccagggcat gccgtcgccg ttcggcgcgc tgacggtcgt
     1081 gtccatcgtc ctgctcgagc tgcccttcgt ggcgacggtc ctggcggtcc tcggcacggc
     1141 ctggctgatg gtgagccggg tggaataccc caagccgcgg ggccgtctcg cggtggcgat
     1201 gctctcctgg atcgtgctgt cgatgggcct cctggccgcc tgggccttcg acgccccgag
     1261 cggccagctc ctgctccaga ccggctgtgc gctgcagctc gtgatgggcg cggtgatccc
     1321 gctgttcgcc acggcccgcc gggtgaacaa cttccgcggc aaccggcgcg aggcgcgcgc
     1381 ggcgcagctc ccgtagcgcc ccggcgtaca cgaacaggcg aagggccccg gaccgattcg
     1441 gtccggggcc cttcgcctgt ctgcccgcct gtacggcccc tgcccgctcg tccgcccgtc
     1501 ccggccggat gggcgagacc gtcagggccg gcttcggccc gtccgggccc cgctcccggg
     1561 ccgggagcgg ggctcggggc ggcagccctc gggaacggac gggatgcgtc agacgaggaa
     1621 gtcgcgtgcg atgttctccg cgacccgctc caggatcggg cccgcctgcg cgatgcactt
     1681 ctccacgtcc ggctcgatct ccgtcagcgg gtaggcccgg cggatcccgg cccggcccag
     1741 cgtctccgcc ggcagggcga ggcgcccgca caccgcgacg acctccttgc cggcggcccg
     1801 cgcggcggcg gcgacgcccg cgggcgcctt gccgtgcagc gtctgctcgt ccagcgatcc
     1861 ctccccggtg atcaccagct cggcgcgctc cagcgccggg gcgaaaccga ggacgtcgag
     1921 catcacctcg atgccggggc ggaagcgggc gccgaggagg agggcgccgt agccgatgcc
     1981 gcccgccgcg ccggcgcccg gcgaggcggc gtactcggcc gccttcgccc ccaccgtgtc
     2041 ctccaggacc ttcgcgtagt gggtgagggc cgcgtccaga gtctccacgt cgtcgggcga
     2101 ggcgcccttc tgcgggccgt agaccgccgg ggcgcccttg gggccggtca gcgggttgtc
     2161 cacgtcgctc gcgagcacca gttcgacgga ggcgaggcgg gggtccagac cggacaggtc
     2221 ggccgtggcc aggtcggcga ggcccccgcc gcccggcccc accggcttcc cgccggcgtc
     2281 caggaaccgc gctccgagcg ccgccagcat gccggcgccg ccgtccgtgg tggcgctgcc
     2341 gccgaccccg aagacgatgg tgcgcgcgcc cgcgtcgagg gcggcccgca gcagctcccc
     2401 ggagccgtgc gtggacgccg tcagcggggc caggacaccg gccggcagcc gctgcagtcc
     2461 gctcgcctcg gccatctcca cgaccgcggt gtccccgcgc agcgcgaacg ccgccgtcac
     2521 ctcgtcaccc aggggcccgg cgacccgtac ctcccgccgc tcgaacccgg ccgcgaccgc
     2581 cgcggccacg gtcccgtcgc cgccgtcggc caccggcagg gcctcgaccc gcacgccggg
     2641 cgcgacccgg cgcagcccgg ccgtcacccg ctcggcgacc tcgacggccg tcagcgaccc
     2701 cttgaacttg tccgcggcga cgaggacccc gcgggccccg tccactgcag cgtccgccac
     2761 ttgctttccc ctcgctctcc gggccccgcg tacatccccg tacgccgagg ccagtcgcgc
     2821 cgctgtgacc ttaaccggag gacgccctcg ccgtcatgcc cctgcccagc ccctggaccg
     2881 tccggatgcg ggtacaccac caccatgacc tctgtgaacg gacagccgcg gctcgccgac
     2941 cgcgtcctgg gcggctggct gggccggatc gcgggcaaca tgctgggcaa gccggtggag
     3001 cagggcgagg tgtggacgcg cgaccgcatc gaccgctatc tgcgggaggc cggggccctc
     3061 cccctgaccg actatctgcc cgagccggcc ggcgacagcg accggctcgc cctgcgcccg
     3121 gagtggcgcg gctgtgtgcg cggccgcatc cacgggagct gccgcgacga cgacgtcgac
     3181 tacgccgtcc tcggcctgca tctgctggag acgcacggct tcgggttcac caccgagcag
     3241 gtcggggacc tgtggctgct gcggctgccg tacctccaga cgttcaccgc ggagcgggcg
     3301 gcgtaccgca acctcgccaa cgggctgaag ccgccgctga ccgccacgta cgacaacccg
     3361 taccaggagt ggatcggggc cctgatccgg gccgacatcc acggctggac ctgtcccggc
     3421 gccccgggcc gcgccgcgct gctcgcccgc cgggacgcgg tgctgtcgca caccggcaac
     3481 ggggtgtacg gcgcgatgtg ggcggcggcg ctgatctcgg cggcgttcac cgcgccgacc
     3541 gtgcgcgagg cggtggagca ggcgctggcc gtgatcccgg cgagcagccg cctcgcgcgc
     3601 accgtgcgcc gggtggcctc gctccacgac gccgggctga cgtgggagga gacgctcgcc
     3661 acggtgtccg aggagaccgc cgggctcggc tggatccaca cggtgcccaa cgccgccgtc
     3721 ctcaccgccg ggctgctcta cggcgacggg gacttcaccc gcaccatcac cctgaccgtg
     3781 cgcggcgggc tggacaccga ctccaacggc gcgacggcgg gctcggtcgc cggggtcttc
     3841 ggcggcgcct cggcgatccc cgcccagtgg acggacccgc tgcgtgacac ggtccgcagc
     3901 gccgtgttcg gcttcgacgg cgtacggatc agcgagctgg cggagcggac gctgcggctg
     3961 gccggcgccc cggcctgacg gcgggccgcg gcgccggacg ggacgccgcg gcgtccggcg
     4021 tcccgtcccc gccgtggctc agcccgtacg gaccggctga ccggcgacga ccgggtggtc
     4081 ccgttcgatc agcccgtggg cggaggcgcc gccgggcgag ccgagctcgt cgaagaactc
     4141 ggcgttcacc gccttgtact gcgcccactc ctgcggggtg tcgtcctcgt agaagatcgc
     4201 ctcgaccggg cagaccggct cgcaggctcc gcagtcgacg cactcctcgg ggtggatgta
     4261 cagcgcccgc tgtccttcgt agatgcagtc gacggggcac tcctggatgc acgccttgtc
     4321 cttgacgtcg acgcagggct gggcgatgac gtaggtcatg ggactctcct cgtgttctgc
     4381 cgcgggttcg ggtgggagga agtgcgggcg gccggggctg cggggcgggc cgggcgggcg
     4441 catccgggcc gccgccggcc tccgtccggc gggtccggcg cccggcccgg cggcgtcacc
     4501 ggggcccgcg gcggacggac tcggggcggg ggcgtctcac ccgcccgccg ccggcgcgcc
     4561 ctccgcgtcc gcctcgtccc gcggcgtctg ctcggcgatc ctcatcgcct cctcgatcag
     4621 cgtctcgacg attctggact cggggacggt cttgacgacc tcccccttga cgaagatctg
     4681 gcccttgccg ttgccggagg cgaccccgag gtcggcctcg cgggcctcgc cgggaccgtt
     4741 gaccacgcag cccatcacgg cgacgcgcag cggcacctcc atcccctcca gaccggccgt
     4801 cacctcctcg gccagcttgt agacgtcgac ttgagcccgg ccacaggacg ggcaggacac
     4861 gatctccagc cgccgctcct tcaggcccag cgcctggagg atctggatgc cgaccttgac
     4921 ctcctcggcg ggcggcgccg acagggagac gcggatggtg tcgccgatgc cctgggagag
     4981 cagggcaccg aaggcgaccg ccgacttgat cgtgccctgg aaggcgggac cggcctcggt
     5041 gacgcccagg tggagcgggt agtcgcacgc ctcggcgagc tgccggtagg cctcgatcat
     5101 cacgaccggg tcgttgtgct tgacggagat cttgatgtcg cggaagtcgt gctcctcgaa
     5161 gagggacgcc tcccacaggg ccgactcgac cagcgcctcg ggggtcgcct tgccgtactt
     5221 ctgcagcagc cgcttgtcca gggagcccgc gttgaccccg atacggatcg gggtgccgtg
     5281 gtccttggcc gcccgggcga tctccctgac ctggtcgtcg aacttcttga tgttgcccgg
     5341 gttgacccgc accgccgcgc atcccgcctc gatcgcggcg aagacgtact tgggctggaa
     5401 gtggatgtcc gcgatgacgg ggatctggga cttgcgcgcg atgaccggga gcgcgtcggc
     5461 gtcgtcctgc gtggggcagg ccacccggac gatctggcag ccggacgccg tcagctccgc
     5521 gatctgctgg agcgtggccc cgatgtccga cgtacgggtc gtggtcatcg actgcaccga
     5581 gacgggcgcg tccccgccga ccgccacgga cccgacctgg atccgccggc tcctgcggcg
     5641 gggggccggc ctcggcggca ccgtcggcac tccgagtgcg acaggcatga cagttcctcc
     5701 ttgaggttct cagcgtccgc cgagggccag tgagggggtg gcggcctctt cccgggcggc
     5761 gtcccgtccg gcgggcaggg attccagcag cgcacgggtg aggtgccggg ccgtcagtcc
     5821 gccggcctcc agcacctgag cccgtgagcc gtggttcagg aagtgctgcg ggatgccgaa
     5881 ggtgcgcacc ggcggcgccg ctccggcgtc gctcagtgcc tgggcgatct gggttccgac
     5941 gccgccggcc cggccgttgt cctcgacggt ggcgaccagc cggtgctcga gggcgagggc
     6001 caccagttcg ggggcgaccg gcttgaccca gcgggggtcg acgacggtga ctccgacgcc
     6061 ctgcgcggcc agccggccgg ccacgtccag gcaggtggcg gccatggcgc cgacggagac
     6121 caggaggagg tccggccgct ccccccggcg cagcacgtcg atcccggcga aggtggtgac
     6181 cgcggggatg tcctcgccgc tcgtgccctt ggggaagcgc agcgcggtgg gaccgtcgtg
     6241 gcaggacagc gcctcgcgca gggcacggcg cagggtggcg gcgtccctcg gcacggccag
     6301 gcgcaggccg ggcaccaggt tcagcagcga cagatcccac atgccgttgt gcgacggccc
     6361 gtcgtcgccg gtcacgcccg cccggtccag gacgaaggtc accggcgcac ggtgcagcgc
     6421 cacgtccatc aggagctggt cgaaggcgcg gttgaggaag gtggcgtaca gcgcgaccac
     6481 cggatgcatg ccgcccaggg ccaggcccgc ggcggcggtc acggcgtgct gctcggcgat
     6541 gcccacgtcg atggtgcgct ccgggtggcg gcgggcgaac tcgctcagtc cggtcgggtc
     6601 gagcatggcc gcggtcaggg cgaccacgtc cggccggtcg gccgccaggt cggccagctc
     6661 tcggccgaac accgacgtcc aggagggcgc gccgcccggc ttcttggcgg aggcggcgcg
     6721 cacggcgtgg aagcggtcgg tctcgtcctg ctcggccggg aggtggccgc ggcccttctc
     6781 ggtgaggcag tgcacgacca cggggcggcc gaggccggcg gcgcggcgca gcgcggtctc
     6841 cagagcctcg atgtcgtggc cgtccacggg gccgagatag gccatgccca ggctctcgaa
     6901 gagcggccgc ggggcgtcgg ggccccgcag cgcggccagg tgggtggcga gcgcgccggc
     6961 cgtgggggcg taggagcggc cgttgtcgtt cagcaccacg atcaccgggc gttcgggagc
     7021 ggcggcgatg ttgttgagcg cctcccaggc catccctccg gtgagcgcgc cgtcgccgag
     7081 cacggcgacc acggcgcggt cggtcacccc gcgcagggcg tgggcgcggg ccagcccgtc
     7141 cgcccaggac agcaccgtcg aggcgtgcga gttctcgatg acgtcgtgct cggactcggc
     7201 gcgggaggga taccccgaca gtccgcccgc ccggcggagc gtggggaagt cctcggtacg
     7261 gccggtgagc atcttgtgca cgtaggtctg gtgcccggtg tcccacagga tccggtcgcg
     7321 gggcgagtgg aagacccggt gcagggcgag cgtcagctcg acgacgccca gattggggcc
     7381 gaggtggccg ccggtgacgg tgcaggtgtc caccagcagc cgccggatct gcggcgcgag
     7441 cgcgcggacc tgccgcgggg tcagggcccg caggtcctcg gggccgcgga tctcccccag
     7501 gcgcggcatg gcggcacctt ctgtctcctg tggctgcttc atgccgcccc accgggtgac
     7561 aggggggcct caccggccag cggtgtccgc ggcacccggc cggtgaccgg gtcggccagg
     7621 cgtccgggca tggagaacac gacgtcctcg gcgatgcccc gctggagctc gacccggtcg
     7681 tatccgagcg cggccagcct ggtgacgagg ccgtggacca ggatttccgg tgcgctggcc
     7741 ccggcgctga cgccgatggc cgagacccct tcgagccatg cctcgtcgag gtgggtctcg
     7801 tcggggacca gatgggccgc ggcgccgtgc tcccgggcca cctcgaccat gcgcagcgaa
     7861 ttgctggagt tgcgggagcc gacgaccagg accagatcgt tgcggcgggc caggtccttg
     7921 acggcgttct gccggttctg gctggcgtag cagatgtcgt cgtcgcccgg ggtgagcagg
     7981 tccgtgaagc gggcgcgcag cgcctcgacg accttggcgg tctcgtcgaa ggagagcgtg
     8041 gtctgggtga ggaccgccac cggggtgtcg tccggcaggc cgagccgccg tacgtcctcc
     8101 tcggtctcga cgacgacgat gcggtcgggg gcctcgccga ggacgccctc gacctcctcg
     8161 tgcccctcgt gcccgaccag caggatggtc cggccgtcac gggcgaaccg caccgcttcc
     8221 tggtgcacct tggacaccag cgggcaggtg gcgtcgatca cctccagccc gcggccggcc
     8281 gccgccgtcc gcaccccggg ggagacgccg tgcgcggaga acacgcagac cgcgccctcg
     8341 gggacctcct cctcgctgtc cacgaagacc gcgccgcgct tgaccagctc cgagacgatg
     8401 tagtggttgt gcacgatctc cttgcggacg tacaccggtg ccccgtacag gtccagggcc
     8461 cgctcgacga tgccgatggc ccgccggacg cccgcgcaga agccgcgtgg ctgggccagg
     8521 acgacgctgc cggccgtcat gcggggtcac ccccggccgg cgccggcacc ggggtggccg
     8581 cggggcgcgg ggtgcgcgcg gagagcctca ggcgcagccg gcgcggatgg tagacggtgg
     8641 ccagcggtac gggacggacg tccatgtccg gctcgcaggt gacccgccag cggccgagga
     8701 tggtggccag gcccagcgtg gcctcggtac gcgcgtacag gtcgccgatg cacttgcggg
     8761 cgccggtgcc gaacggcatg aacgcctggc gggccgcggg cgagacccgg tccggcagcc
     8821 agcggtccgg gtcgaacgcc gtggggttgc cgaaggcgtc ctcgtactgg gccaccgcgg
     8881 ccgggctgaa gacgatggtg gttccctcgg gcagcctgcg gcccgccagt tcggtctcgg
     8941 tggcggtgag ccgggtgaac agccaggccg gcgggtgcag ccggagcgcc tcggagatga
     9001 tccggtcggc cagggagagg ttcggcaggt cgtcccagtc cggggcgcgg ccgccgagga
     9061 cggtgtcgat ctcctcgtac agcgccgcct cgatctccgg gtgctgggag agcaggtaga
     9121 acacccaggt gagggtgccg gcgacggtct cggtgccggc ggccatcacg gtgatgacct
     9181 ggtcgtggat ctccttgtcg tcgagccggc cgccgtcgtc gtcgcgggag gccagcagcg
     9241 cggcgagcag gtcgtcgtgc gcggcgccgt cgctgcggta gtcgtcgatc agttcctgcg
     9301 tggtgcggtg caggaagcgc aggttgctct cgtagcggcg gttggccggc agcggcaggc
     9361 ggcggatgaa gcggggcagg aacatctggc ggaacagccc gttgagcacg acgtcgaagg
     9421 cccgctccac gccggccgcg agctcggggc tgaccggggt ggagtacagg gtgcggccga
     9481 ccgtgcgcag ggccatgccg tacagctcgg ggaacgcgtc gacgaccatg ccgtcgtgcc
     9541 agcgcgccgt cgtggcctcg atctcggcgt gcatggcggt cgcgtaccgc ttgagctggg
     9601 tgcgggtgaa cgccgactgc atcagccgcc gctgccggcg gtggtcggcg aaggggcagg
     9661 tgaccagacc gttcccggcg atgtcgcggg cccggtcgta gaagacgccg cccttgtcga
     9721 agatgcggtc gttggtcagc acgtaccgca gcaggtcggg gtgggtcggg acgtaggccg
     9781 acgtggggcc gatcttgatc tgcaccaggt cgccgtgggc cgacagcgag gtcatgaagt
     9841 tcaccgggtg gcgcatcatc tgcagggcgt gtcccacgac ggggacggcc ccgggcgccg
     9901 cgcccgcgac gaacgtggtc tgctcggaca tccgttcctc aacttcctgt ctgtgcctgg
     9961 ggtgtgacgg ctgagccggt cgcgcggccc agggcgggcc tcatcgggcg gtgctgccga
    10021 gctcctccag gtagccctgg gagccgaccg cgagcgcgaa ctcggcgtcg tagcggcccg
    10081 aggagcggtg ccagtcgtag gacccgcgga tcaccgtgcg caccgcgtcc gtgcggtacc
    10141 gctccagcgc ctcgcgctcg gcctcgtcga gccggtagat gtcggcgacc ttcggcaggc
    10201 aggactccag cagcaggaac tgttcgagcc gggcgtgcac ctcctgctgg atgtgggaga
    10261 tgctgcggct ctcggaccag ccgtgctccc ggcgcaggat catgaccatg ttgttccgct
    10321 caccgcgggc ctcttccttc tccagggagg cgatgtcgtt gagcatcagg ttgacgtcga
    10381 tggcgatctg gagcatcgcg gagagcacgg cgctgtcgaa gacccggtgc ggcacctcga
    10441 agcggccggc gcgttcggcg aggtcgaccg tcggctgcac cccgatggtc tgccggcgca
    10501 cggcgaggta ctgggccgcg gagtcgtacg gccggtcccg gaagcggctc tccgcctcgt
    10561 cgacgtaacc gcccaagtag ctgcgccagt gccgggcgct gcgcgcgcac caggcgggtg
    10621 tcatgccctc gctggtacgc cgccagatgt cggcgaagcc gtgggcgatg gggggcgcgg
    10681 tgtcggggag ggggccgtcc agcgccgccg cgaccgcgtc ggtgagctgt ttggtctcct
    10741 ccgggttctc gccgcgcggc ccgtcgaaga ggtcgtcgaa gaggaagaac cacgacatca
    10801 ggtcgacgcc caggtccagg tcggcgccga tggcgtgcgg atagaagcgg gaggccaggt
    10861 cggcgtagcc gccgcgcaga tgacgcctcg ccgccgcctc ggacttgatc agcccgagcg
    10921 accgcggcca ggcgagctgc tcggcgtcgg cccgcgcgtg gtccgggctc tgccgggccg
    10981 gcaggggtat gtggaagtcg acgtcctggg gcatgagcgc atccttggat atgggttgcg
    11041 gggggcagcg ggcatggtgg tgccctggcg gggatgctgc gctggtcgga gggtcggggg
    11101 tcgggtgccg gaaaggggcc tgcgggtgag gtggtaaggc ggccggtccg gtgtcagacc
    11161 tcgcggtcga cgacgaaccg cccgagcgcg aggagttcgt cccgcgctgc ggcgtgcagc
    11221 tcggcaccgc gcagcgcgtc ctcggccagc gccatccgcc gggcggcctc ggccagcgcc
    11281 cagtcccggc cgccggcggt ctcgatcagg ccggccacgc gccgcagttc ctcctcgtgc
    11341 ggttcgccgg gggtggtgag ccaggcggcc agctcgtcgc cgagcgggcc gccccggttc
    11401 agtgcgtggc tcaccggcag ggacttcttg cgggagcgca ggtcggagtg gaccggcttg
    11461 ccggtgacgg cggggtcgcc ccagatgccg aggacgtcgt cgacgagctg gaaggcgacg
    11521 ccgacctggt cgccgtagag ggcgagcgcg tccaccgtcg cctccggtgc cccggcgagg
    11581 acggcgccga tcgcggcgct cgccgacatg agcgcgccgg tcttcccggc ggccatgtcg
    11641 atgcactcct cgaccgtgac gtacgagcgc tgttcgaagg ccaggtcctg gacctggccg
    11701 cggatcagat gccgggtggt gcgggccagc agccgggcgg cgggcgccgc cgtcggcagc
    11761 ccggtgtcca gcagcacctc ctgggcgagc gccagcagcg cgtcaccggt caggatggcg
    11821 ctggagggac cccacagctt ccacacggtg cgccggtggc ggcgctcctc gtcaccgtcc
    11881 atcagatcgt cgtgcagcag ggagaagttg tgcacgagct ccacggcgac ggcgccgggc
    11941 agggcgacct ccgccggtgc gccgaccgcc tcggccgaca gcagcgcgag cgccggccgt
    12001 acggccttgc cggagtcggc gctggtgggt gcgccgccgg cggtgatcca gccgaagtgg
    12061 taggccgcct ggtgacgtga gcggtggtcg agccggtcga cggcggcgcg cagcgccggg
    12121 gtgatcgtga cccggctgtg gccgagacag gcgggagcgg tgctcatgcg gcgacctccg
    12181 cgtgccaggg gtcggtcgga tcgtcgaaga tgctgacgac ctggcgcatg atgcgccgtt
    12241 cggccggatc gaagggctgc ttggcgtgga cggtgccgag ctggtcccac atgacgatgt
    12301 ccccgggctg ccaggtgtgg gtgtaggtgt actggggttt gcccgcgtgc gacagcagtt
    12361 cgtcgagcag cttgcggctg tcgtcggggg cgaggtccac gatccgcttg gtgttcaggg
    12421 tgctgacgta gaccgactgg cggccggtgc gcggattgcg ggcgatcagc gggtggatgg
    12481 tggaggtgcc gtcctcgggc tggatccgtt cggtgctctc gccgagggac acctcgccct
    12541 ggagctcctc ctcgatggtg tcctcgtacc cggtgcgcag ggcgtggcgg acccggtagg
    12601 tgtgcaggcg ccggcgctct tcgttcgaca gcgactcgta cagggcgtac atgtcggtga
    12661 agagggtctc cccgccaccg gaggacggca cttccacggc ctccaggaag ccgacctggg
    12721 agacgcaggg gcggaaggag tagtcggtgt gccagcccat ccactcggcg tcgccgacgc
    12781 cgatcttgcg gccgtcctcc accaggttgg agacgatcag gatctcgttg tggtcgggat
    12841 gggcgccgct ggtcagtccg gttttcggga tgtacccgaa gcggcggccg aaggccagga
    12901 actcctcgta ggagggggtc tcgtggccgc ggaagacgag cacgagatgc gcgtcgagcg
    12961 ccgcccagat ctgctccacc tgggtcttgt ccatgtcgcc ggtgacttgg gcgccgcgca
    13021 cgacggcgcc gagagcggcg ccgggtatcg gcgttacgtc catgggcgtt gccgcctttc
    13081 gcgtaagggt ggggtggtca gcgcagttcg aggccggcga gatcgcccgc ctcgcgccag
    13141 cgcctgagga tgttcacgaa ctccaccgag ccgccgccgt agctggagtt gagcaggggc
    13201 agtgagctcg ggtcgccctc gttgttgtag aggccggggg tgcagttctc gaggaagtcg
    13261 atgtcgttgc tggcgagccg gaggatctcc tcgacccatt ccttctcgcc cgcctcggac
    13321 gcctccacga cccggtggcc gcgctcctcg acggacttga cgatgtacgc caggtgccgg
    13381 gtctgctcgc tcagcatgta ggcgatgttg acgtgccggc cggcctggat cttggacagg
    13441 atgaagcagt tgggaaagcc gttcacctgg agcccgtgca gggtgcgcgc cccgtccgcc
    13501 cacttctccg acagcttcag gccgtcgcgg ccgatgatgt cgtagccggc gcggtcggtg
    13561 tacgggacgg agaactcgtg ctcgtagccg gtggcgaaga cgaggcagtc gaccgggtac
    13621 tcccggccgt tcgcgaccac cccggtccgg gtgagccgct cgacgccctg cccctgggtg
    13681 tcgaccaggg tcacgttggg ccggttgaag gtctgcaggt agctgtcgtg gaagcagggc
    13741 cgcttgcagt acacccggta gtacggcttg agggcggcgg cggtcgcggg gtcggtgacg
    13801 acgctgtcga tgcgggcgcg cagctcctcc atcttgagga agtcggcccg ctcggccgcg
    13861 agcgcccgct ccttcgggtc gcccccggtg tcgccggtgg gcaggatggc ggcggccagt
    13921 ttggccgtgg tctgggtcca gcggtcctgg accaggtcct cgtcctgcgg gacaccggag
    13981 gtcagcgcgt ggaagttctc catgcggcgc tgctgccagc ccggttcgag gctgtccgcc
    14041 cagtcgggcg gggtgggccg gttgccgcgc acgtcgaccg cggccggggt gcgctggaag
    14101 atgacgagct gctcggccca ctcggcgagg tggggggcga gctggacggt cgtcgagccg
    14161 gtgccgatga cgccgaccgt cttgtccttc agcttggtca ggccgccggt gctgtcgccg
    14221 ccggtgtagt cgaagtccca gcggctggtg tggaaggagt gcccggcgaa cgtctccagg
    14281 cccggcagct tggggagttt gggccggtgc atcagaccga tcgacatggc cacgtaccgg
    14341 gcccggaacc gatctccgcg gtcggtgctc accagccacc tcccggcggc ctcgtcccag
    14401 cgcagctcgg tgacggcggt ctggaagagg gcgtcgcggt agaggtcgta cttgtgggcg
    14461 atcttctgga gatgggcgaa gatctcgggc ccggtggagt acttctcggt gggtatcgtg
    14521 ccgatctctt cgagcagcgg catgtagatg tagctctcga cgtcgcaccg gacaccgggg
    14581 aagcggttcc agtaccaggt gccgccgacg tcgccggcct cgtcgatcag ccggatgcgc
    14641 tcgaggccgg tctccatgcg cagatgggcg ccggtcagca ggccgccgat gccggcgccg
    14701 acgacggcga cgtccacctc gtcggtgagc ggctcgcgct cctgccgctc ggtgtagggg
    14761 tctcgcgcgt agcggctgaa gtcaccgcgc gcgaactggt aggtgcggcc gacgctgcgc
    14821 ttgtcacgtt cctgccggta tttctccctc accgcttcca ggtcgatggt cagggtttca
    14881 tcgcggtcgt cgctttcggc gcgggccacg gctcctcctc gggggaaggg ggcggaaggg
    14941 aaatatcacg ccatacgtcg tcgaactggt cgcgcagccg ctgcggggcg tcggcgttgc
    15001 tgaagaggta gaagcggtcg gtgccgaggg cctcccacac gagcccggcg acgtcctcgg
    15061 cgctcaccga ggtgtcgccg cccgcgccgc gcggggccgt cagaccctgg accatcgggg
    15121 tgtcgacccg gccgggacac agcaccgaca cccggatgcc ggtgccccgc agatcggcgc
    15181 gcagactgcg ggcgaccgcg aggtcggcgt gtttggaggc ggcgtaggcg gcgctgccgg
    15241 cgccgacgac gaaggcggac atcgaggcgg tgtggatcag gtgggcgggc cggccgcgct
    15301 ccagcagccg ggggacgaag gcgcgggcca ccaggacgtg cgcccagtgg ttcacctcga
    15361 agacctgccg catccgttcc agcggcacct cccacagggg ctgtcccacg gggccgagga
    15421 ccccggcgtt gttgcacacc acgtcgacgt cgccgagcag gccgaacgcc gtgtccgcga
    15481 gctgttcgac ggcgtccggg tcggtcaggt cggcggtcac cgcggtgacc tgggcgtcct
    15541 gtgcggtgag ttcggcggcc cggcggtgca gggcgtcgtc tgcgacgtcc gccatgacca
    15601 cgcgggcacc ggcccgtgcg aagcgggcgc tgagggcgag gccgatgccg ctggccgcgc
    15661 cggtcaccac ggctgtcctg gtgcggaact gcacttggct ctctccgctt ctgcgcgcgg
    15721 gcacgccgca ggacggcgcg ccgttgccaa cgagaaggtg tggatcggat cgcgccgttc
    15781 gaggggcgcg ggtgtcagct cgggtcgggg agcttcagac tgatcacgag aacggtcacc
    15841 gcgaaacatg tcagcagggc gagcacgagc acggccgccg acgccgtcga cagccacccg
    15901 tccagggaga cgtagagggt cccaccgacg gtcgcgccca gcgcggtcgc catctgctgg
    15961 ctggtcacca gcactccgct gcccatgccg gcctgcgcgc ggggcacgtc ggcgaggatc
    16021 atgcggaaca gcgtcgggcc ggtcagcgcc gcgcccacgc cgaagagacc gatcccgacg
    16081 agcacgagcc ccagggaggg acgcggccag cccagccaga tcaccagcgc cagcagcagc
    16141 aggccgatgc cctggacgag ggcgcccagg gtgacgatcc ggccgcccag ggccgccgcg
    16201 atcctcgggg tgaacagcgt caccgcgaag aacgccacgg cgaacggcgt cagcaccccg
    16261 ccggaggcga gcccgtccag gccgaagtgt ccctgcgcga tcagcgcgta gacgaacagg
    16321 aaggcgccga agccggccga gaacggcacc atcgccgcca gccccctgcg catccccgga
    16381 tgggacagca ccgacgggga cagcagcggt gagccgcccc gcgcctccag ggcgcgttcg
    16441 gtgcgtacca gcgccagcgc ccccaccgcg gcgaccgcga gcagcgacca cagccacagc
    16501 ggccagccca ggtcggggcc cgccacgacc acggccagga cacagaccat ggtgacaccg
    16561 aacagcgcgg tgcccgccgg gtcgaagccc ggcttcgtgt cggccttggt cgcggggacg
    16621 cgccggacgg ccagcagggc ggccactccg atcggcacat tgatcgcgaa gaccgaccgc
    16681 cagcccatcc cggcgacgtc cagcgagacc agcagcccgc ccaggatctg accgacgacc
    16741 atgccgaggg ccgcggtcgc gccgtacctg ccgatcgcac gggcgcgcgc ctggccctcg
    16801 gtggccgcct ggatcgtcgc caggacctgg ggtacgagca tggcggcggc ggccccctgc
    16861 agcagccggg ccacgacgag gaactcgatg gtcggggcga gtccgcacag cgccgaggtc
    16921 gcggtgaacg ccgcgaggcc gtaggcgtac agccgccgtc tgccgaaggc gtcgcccagc
    16981 cgtccgccca gcaccaggcc gagggcgtag gtgaggccgt agccggacac caccagctcc
    17041 agtgcggcgg ggccgccgtg gaggtcgtca ctgatcgacg tcagcgccac attcacgatg
    17101 gaggcgtcca cgatggacag ggcgtatccg acgagcacca ccacgaggcc gatgccgctg
    17161 agccccgcgg cggccggttc ggtgccggcc gagggctgcg gtgtcgcgtc ggactctttc
    17221 agagggggga ggccctcgcg tttcgtcatg cgctgcctat ccaggcgtgt gtggggggac
    17281 ggtggaggag ggtgcggggc gacaacgcta ctcgacggtg gcgggggtgc cggtgatctt
    17341 cgacatgact cccttggagg ggtccttcgc ggactccggc cagggggtca gggcgttgaa
    17401 cccgcggtgc gaggaggcgg gttggatgcg ggtgtccatc gacatccgca tgccggccgg
    17461 gttcgccgag acgttgggga tggacttgtg gcacatgaag gcgtggaaga ggatcacgtc
    17521 gcccggctgc atcggcgaga acagcagcgg ctcgtccgcg ccgagctgct ccggcgggat
    17581 gccgcgcacc gggtggccga agcggcggaa gttctcggtg acgacgtgct cgcgcgggcc
    17641 cttcttgtgg ctgccgtcgg cgacggcgac cccgcctatg tcgcgggtcg tcgggagcag
    17701 cggcacccag gcggtgcgga agtccttgtt cgggccgatg tagaagccgt cctggtgcag
    17761 cggcgtcagg aagctcggct ccgcggagcc cgcggcggag gggtagtagc ggatcgtcgt
    17821 cgacttgaag acgaagacgg gctcgccgaa gaccttctcc cagaccttga gggtcgaggg
    17881 gtggttccac aggtcgtcgt acttgacgta gtcgtgcatc gccacctcgt cgaccgcctc
    17941 gaaggactcg atggtgaggg tgtccagcgt ggtgccgggg gcggcgtggc cgagtgcgat
    18001 caggccctcg agcatctgct cggcggcggt ccgcaccagg tcgcggtcca gggcgccgcg
    18061 cagatagagg tagccgtgct cgtcgtagaa ccggtcgatg gcctcacggt cgtcgagaag
    18121 aggcgtgcag tcgacgtagt cgctgaaagt ctccgtcatg gttccttgtc ctcgtgacgt
    18181 ctgtgcgtgg gggcgtcgaa catccgggcg ggccgacggc ttcgatggcg ccgggtgagg
    18241 tggcggtgac gagggacgac cgccggggac ggcggtgctg ccgttcagga gggtggggac
    18301 cggaaccggc cggaaggacg gcccggtgcg cacggcccgg tcttgcggct tgtgccacct
    18361 gtgaccatgg acggtgggcg gctgcggtct tcgcgcgtgc gatgccgctc aaaaggtgac
    18421 ggggatttca tcgaacccgc cggtgatgcg gtgctcctgc cagcgcagcg tctcctcggg
    18481 taccgcgagc cgcaggtcgg gcagtctgcg gaagagccgc tcgaacaccg cggtcagctc
    18541 gatccgggcc agcgtgcggc cgatacagtg ccgggcgccg tggccgaagg ccatgtgcga
    18601 cttgggcttt tcccgggtca ggtcgaacag gtcggcgccg gggtatgccc gctcgtcgta
    18661 gttggccgcg ccgatggcca gcatcaccgc gtccccggcc cggatcaccg tgtcgccgac
    18721 ggtgatgtca ctgtgcgcgt agcggggtat tatcgcgttc gatccgttgc cgcccacgcc
    18781 cagccgcaga atttcctcga ccgcggccgg tgcgagttcc ggtttctcga ccagcagggc
    18841 acgctgggcc ggattgcgca acaacaacag ggtgcccaga tcgatgcgaa caatggtggt
    18901 ctcgtagccg aacaacagca ccgcgttgcc cagatgggca atctccgcat cggacagtgc
    18961 gtggtcttta tcggcgatca gctcggacag gatgtcgtcg cccggctcga ttcgcttgcg
    19021 cgccaccagt tccgtcatgt agtcgaccac ctgttgaaag gtgttcgccg aatgctggtt
    19081 gtcgctctgg tcgaatgtgc ctctcgccca ctgcccgaac cgctcccggt cggccagcgg
    19141 cacgccgagc agatcgcaga ccaccatggt cggcaacggg aacgacagcg cgcggtgcag
    19201 gtcgaccggc ggagtgctgg cggccaactc gtcgagcagc tcgtccacgt gctgctcgat
    19261 ccggctcttc atcaggcgca tccggcgcgt ggagaaccgg ggcaccagca gggcgcgcat
    19321 ctgcgcgtgc cggggggcct cggtgtgata gtcgtccccg gccatcagcg cgaccatgaa
    19381 ggccctggcc gcgcttttgg tcgtccgctc cgggtaggga ttgctgagag cgagccgacg
    19441 gtcggcgagg agcgtcctca cctcgtcgta gcgggtgacc agccaggcat cctcaccggc
    19501 ggtgcgcacc ctggcgatcg gcccttcctt ctgcagcgcg aacatctggg gcgcgatgcc
    19561 gataatgtct ggattatcga acggtaacct cggaagttcc gtcatgcggc catgttcaca
    19621 cggttagatg ttcatgtcaa cgagtagccg gaatcaggga tttcaccggc cgagtcggcg
    19681 taggacgact cttacggtcg gcgcgcgccg gccgccgata gcgcggaatg gatatcgcgc
    19741 aggacgcctt ccggcgcaat gggccgactt tccggtcggt aatgagttga atccccactc
    19801 gtctaaagtc ggagaattgt gccgactcgg cctccgaggc actcccctgc tcttccggca
    19861 cggcaccagg gcgggcaccg gtacggtccc gccgtcggac gccgtcccgc tgccgtgccg
    19921 cggctgacac cggcggacgg cccggctcga tgctccgcgg cggcaacggc acgagcctgg
    19981 ccccctcctc gctgccggcg ggccccccga cccgccggca gcgagccggg cctgaaggcg
    20041 acccggtccc cccgccgtac cgatcccggc tcagtccgtc actcggtcac gcccgcgacc
    20101 agcttggtcg tgtcgatgag gcggttggag aatccccact cgttgtcgta ccagccgaag
    20161 acgtgcacgt ggcggccgtc gatgacctgc gtgagcaggg agtcgaagat gcacgaggcc
    20221 gggtccctga cgatgtccgc cgagaccacc gggtccgcgg tgtagcgcag gatccgcgcg
    20281 aggtcgccgt cggccgcctt gcggaacagc gagttgacct cctccaccga cgtctcacgg
    20341 cccacccgga cggtcaggtc ggtcagcgag ccgacgggga cgggaacccg caccgagaaa
    20401 ccgtcgagct tgccctgcag gctcgggagc accaggccga tcgcgctggc ggcgttggtg
    20461 gtggtcggga tggtgctgag gttggccgcg cgggcacgcc gggggtcggc gtgcgggccg
    20521 tcctgaaggt tctggtcctg cgtgtaggca tggatcgtgg tcatggtgcc gcactcgatg
    20581 ccgagcgcgt cgtcgagcac ccgggccatc ggagccaggc agttcgtcgt acacgaggcg
    20641 ttggagacga tcgtgtgctt ctcggggtcg tacaggttgt cgttgacccc gtagacgagg
    20701 gtgaggtccg cgttcttcgc cgcggcggag acgaccacct tcgaggcccc ggcgtcgatg
    20761 tgcttccggg ccttggcagc gtcgttgaac acgcccgtcg actcgatgac cacgtcgacc
    20821 ccgagacggc cccagggcaa ctgtgcgggg tcgcgctcgc cgaggacctc gaccacggtg
    20881 tccccgaccc tgagcgacga gccttccgcc acgacctcct gcggcagcgg cccgtacacg
    20941 ctgtcgtact tcagcaggtt cgccagggcc ttcgcgtcgg tcagatcgtt gaccgcggcc
    21001 acgcggatgt cggcgccgga cgcgagcagg gcacggaagt agctacggcc gatgcggccg
    21061 aagccgttga ttcccacagt gattgtcatg attgccgtcc tggttgttgg gagcctcgcg
    21121 gtactggctg cgcggggtgt cgtggtccat cacctgccgc cgcgtccgca ccggcgcacg
    21181 gcccggctcg ctgtcctgcg gcgaacggct cgagccgggc ccactgtcca ttcgtcagat
    21241 caccacgcct cacagggcgt gatcgcccac gaccaagatc cactttcgca acaggcccta
    21301 gcgctcttga ggtaggaatg acgcgccgtt gcgccggggt gccgatgccg accccgcacc
    21361 tgcagaaggc gcgggccacg cgatcgatca ggatcttata taagcctgcg atacatttcc
    21421 agggtgactt ctacccagcg tgtccccctg catgacgact tggatgtcgg cgatctcacc
    21481 caggcgatag agaacttcaa ccgctactac atccgccttc ccacggtgca gaagctgtcg
    21541 ttcacgacac tgtccgtgct ggacacactg gcccacggcg gcccgaagcg gttgaccgaa
    21601 ctcgccagga ccgaacagat cagccagccg gggctcaccc agctcgtcac ccggctggaa
    21661 cgggacggac tggtcgaacg ccgccccgat ccgacggacg ggcgcgccgt gctcgtccac
    21721 atcaccgacc ggggccggaa gatcggccag gcccggcacg aggaccgggg ccgtcatctg
    21781 ctcccggtga tcgcccggct gacgcccgcc gagcggcggg cgatcgccgc cgccctgccc
    21841 gccctgtccc gcctcgcgga gctgggcacc caggccggac ggtagggcgc tcgcccgccg
    21901 cgccggggac ggaacggccg gccgccgccg gtcgcgtacc cgtacggccc gtacggctca
    21961 gccctcgttc gtgcggggcc cggcgtcgat ctcccgcagc gcctcgtccc gttcggcgat
    22021 cttggcctcg gtgcggtgac cgcgcgctat gtagtcccgg acgacgagtt ccacggcgtc
    22081 ctgaggattg cccaccccgg cgagcaccat gacttcgacg acgagctggg cgtccaggga
    22141 gacggtgacc ttggccatgc acgggac
//
