LOCUS       NZ_LN831790            22651 bp    DNA     linear   CON 08-APR-2024
DEFINITION  Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 =
            NRRL B-24963) chromosome 1.
ACCESSION   NZ_LN831790
VERSION     NZ_LN831790.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Gomez-Escribano,P.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2015) JIC, Department of Molecular Microbiology,
            Norwich Research Park, Norwich, NR4 7UH, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001013905.1-RS_2024_04_08
            Annotation Date                   :: 04/08/2024 03:45:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,096
            CDSs (total)                      :: 7,005
            Genes (coding)                    :: 6,806
            CDSs (with protein)               :: 6,806
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 82 of 199
            Pseudo Genes (incomplete)         :: 160 of 199
            Pseudo Genes (internal stop)      :: 10 of 199
            Pseudo Genes (multiple problems)  :: 49 of 199
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:33:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 642179
            Orig. end                         :: 664830
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN831790.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22651
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="7"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22651
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22651
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12651](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12651)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(101..114)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    complement(979..993)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.8"
                     /tool="antismash"
     misc_feature    979..994
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.43"
                     /tool="antismash"
     misc_feature    2436..2449
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    2699..2713
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    complement(3160..3175)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    4063..4079
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.23"
                     /tool="antismash"
     gene            4306..6165
                     /locus_tag="BN2145_RS04200"
                     /old_locus_tag="ABM27_RS04115"
     CDS             4306..6165
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="BN2145_RS04200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04115"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_049976666.1"
                     /transl_table=11
                     /translation="MPRTTVKLLGSFEVESQGRIITISSGRQRTLLSVLALEAGQLVPT
                     ERLAEHLWGEEPPPSSRTTIRGYILRLRRALSPRTAREARPVIASGRHGYQLLLPPESV
                     DVHQFNSLAARAAAARDSVGENDLLRRALSLWRGPALCDVPGDALHRGVLPALEERRLQ
                     VLERSVEVALARGEHAQAVVELRRLVAEHPLRDGLWGQLMLALYGAGHQSEAVYQYERC
                     RGILAESLGVDPDPRVRELHRLMLVEDPALGAVRQSAPPLPPSGPGRNTEARSASAMRQ
                     DLPSHRLPEAPALFIGREQEQAALSVIAGEEYPGGTRPIIIDGAAGVGKTALALAWAHR
                     AADRFPGGRFYVDLQGFGPADALDPADALMVVLAALGVPPGRLPAGVPARQALLRTRLK
                     GRQALLLLDNAVDAEQVRPLLTGCATVLVTSRDQMRGLVVSDGARRLTLDRLTPVAAQH
                     LLTALIGHERGGAQAEALGDLASLCGCSPLALRAIAESATRWNGLPLEELAAGLRGAPC
                     WLSSLRTGEDRTDPVSVLSWSYDKLGPAPARLYRAFGSYRERRVTAVAAAGFAGVPVSA
                     ATEQLDALARLHLVEERVPGCFDLDELPRAFARLLPRTSDGAG"
     gene            complement(6194..7975)
                     /locus_tag="BN2145_RS04205"
                     /old_locus_tag="ABM27_RS04120"
     CDS             complement(6194..7975)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="BN2145_RS04205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04120"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_047121495.1"
                     /transl_table=11
                     /translation="MKDSRWQLLRPVAARHRRELHSIAAWSLLGALPVLLSGRLVAHAV
                     DHGFLADDAVTGFLTLGGYGAALAVGSFAAWRAMAPMATVAEAVRDHLVRTTVSGGLRR
                     AVAGGVSSGGESVTALTSQTENARQILAALLMSAPSTGLTAAAALVGVVSLAPVSGLLA
                     LLPALTVGVVVVVRLSRSWRLRYSASLAADEHMTEQIAQRVQGLRDVVACGATRRARED
                     TDHAVDAQADAAAAVARASGARVGAVALGARLPLIALLVTAPWLSAQGALTPGELVGAV
                     TYLVSSLEPALRSLVQSVGNLALELGTVLARLTEYHREPKPGRVAESAPGTGTDGRCRR
                     RPAAPEPVPPDIELTLRAVTFRRGEGTDPPVLDRVCVTLPAGGHLAVVGPSGAGKSTLA
                     DLVCGLERPESGQVLLGGVPLPDLDPAWLRRSIALVPQEAYVFAGTVRDNLGYLAPEAD
                     DDRLDRAIEALDITALLAELGGYDGELRRPDLLSPAQRQLLTLARVYLSPARIVILDEA
                     TCHLGIAAEQRVERAFAQRGGTLVVIAHRMPSAARAQQVLVVDAGTVHSGTHRELLRTC
                     ATYADLVGHWGETGAPP"
     gene            complement(7972..9732)
                     /locus_tag="BN2145_RS04210"
                     /old_locus_tag="ABM27_RS04125"
     CDS             complement(7972..9732)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="BN2145_RS04210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04125"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_047121496.1"
                     /transl_table=11
                     /translation="MRYTDRLLAQTVRAAGGHSAGLLAVAALDPLARLVLPAALAAAVD
                     AVVTGRTAWRQVLSACAVLAVSTACEAARETLQTTAEARGARALRRRLLHRVWDLGVTA
                     QARFDTGDVLSRVMESTAGAAAVTPVLVSTMSLLGTSVGGLVALFLIDVGLGLFFLAGV
                     LLTWWLLRWFVPLAGRVTLEYQEAQSDLSSRFVGALTGLRTIRASGTADRETARILTPL
                     SRLTAAGRGFWAAQRGAAWRIGLIMPVMQLGVLALAGHSLLHGRISHGEMLAAAGYLAL
                     ATGLMKQTAVFARLARARAGADRVGAVLRAGTAAGGRRPLTPGPGRLELRGVALCAKGR
                     PVLRGIDFTVPAGTEVALVGPPDSGASALARVAGGLVPADQGTVLLDDVPLHEVRPGEL
                     RDAIAYAFERPLLVGETLRDALTYTDRPPAAGRLAASLRAVHAEEFTARLPRGLETPVR
                     RLRLSGGEFQRLGLARAACRDARLVILDDALSSVDTVTEARVGTALGRLLADRTRLVVT
                     HRAATAARADLVAWLDAGTLRALAPHAVLLRDPAYRAIFRCGEEGDTASPSKPAHSSDG
                     PTAATVRTRT"
     gene            complement(9841..9972)
                     /locus_tag="BN2145_RS38260"
     CDS             complement(9841..9972)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN2145_RS38260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_258958031.1"
                     /transl_table=11
                     /translation="MEHDEKTPYETPAVYGLGAFAEETGLYGVRNDEEINWHFDYWT"
     CDS_motif       complement(9898..9972)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MEHDEKTPYETPAVYGLGAFAEETG"
                     /locus_tag="BN2145_RS38260_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(9841..9897)
                     /prepeptide="core"
                     /locus_tag="BN2145_RS38260_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-0.20"
                     /molecular_weight="2339.5"
                     /monoisotopic_mass="2338.0"
                     /core_sequence="LYGVRNDEEINWHFDYWT"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MEHDEKTPYETPAVYGLGAFAEETG"
                     /leader_location="[9897:9972](-)"
     misc_feature    complement(9929..9944)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            complement(10001..10516)
                     /locus_tag="BN2145_RS04215"
                     /old_locus_tag="ABM27_RS04130"
     CDS             complement(10001..10516)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="BN2145_RS04215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04130"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_078647986.1"
                     /sec_met_domain="PF13471 (E-value: 6.1e-24, bitscore: 82.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPVLPSRPLRPRLAVRIRVRLLVLVARVLAKRSPQCIRRVMTA
                     FSAGTRAAGHGEARQARDEVLSVSTRCCGPSACLPRSIAVALLCRSRGTWPTWCVGVVA
                     APPFRAHAWIEVAGEMVDEPVDSACYRRFFAVEPAPARGFGHRGQGLGRSAAGGRPETR
                     SARSESPR"
     gene            complement(10513..10770)
                     /locus_tag="BN2145_RS04220"
                     /old_locus_tag="ABM27_RS04135"
     CDS             complement(10513..10770)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="BN2145_RS04220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04135"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_029380935.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-20,
                     bitscore: 71.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4e-12, bitscore: 44.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPLMAEQVSVVETEYGMVLLDERTGEYWQLTPSASTIVARLRDG
                     GGVEEAVVALTRAFDVNEETARRDTLALVERLVQLQVMTR"
     aSDomain        complement(10522..10755)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BN2145_RS04220_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="6.10E-23"
                     /identifier="RREFam002.1"
                     /label="BN2145_RS04220"
                     /locus_tag="BN2145_RS04220"
                     /protein_end="83"
                     /protein_start="5"
                     /score="71.7"
                     /tool="antismash"
                     /translation="AEQVSVVETEYGMVLLDERTGEYWQLTPSASTIVARLRDGGGVEE
                     AVVALTRAFDVNEETARRDTLALVERLVQLQVM"
     gene            complement(10774..12651)
                     /locus_tag="BN2145_RS04225"
                     /old_locus_tag="ABM27_RS04140"
     CDS             complement(10774..12651)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="BN2145_RS04225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04140"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_047121497.1"
                     /sec_met_domain="Asn_synthase (E-value: 5.2e-28, bitscore:
                     97.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPCVPRWFFVMLPDSDEAAALADRLPDTGTRRIPHASGRPWLVV
                     ALPGEQIVTGEAGADRVAVLGYSSATPAGLRTAAERAGSVEAFDALSHTLAGGFHLAAS
                     VGGRLRVQGSAAGVRRVFHTVLGGITVASDRADVLADLGGHRYDPTTLAIRLLRTLPHP
                     LGEQPLWQGVDHVPPESYLRIDADGRGAMMRRWWRRPEPHLTRRDGARLLRTALADAVA
                     VRTQAGGVVHCDISGGLDSTPITWFAAQGSARIVAATAYNADPGGTDDLRWARRALAVM
                     PSVQHRVLSLDKLPGFFEGVSEVDTRWDEPTAACLAAPRMRANIEDALSHTARMYLNGL
                     GGDHVLRGLPAWEHTLFRSRPWLAWQRARTNRMLSGESIATTARGLLDRRGYAQWLHAA
                     AASARREPSKDHRIGFDWDQPFAWPLWMTQDALRAVRGRIEELSATVEPLGQGRADHSE
                     LAMVRDGARVVRGTSQLGADAGLPFEAPLLDDRVVEACLAVRREERVSPLEIKPLMKEA
                     MRGLLPDDFLVRTTRAGGSPQSVRGYAAHHAELLDLCEASPLTDLGIIEIGALRRHNRP
                     QAGHRPDGHLVTTVNCALFLRNQVRGCAATPGVAHALPSESGPARALEE"
     gene            complement(13280..>14260)
                     /locus_tag="BN2145_RS04230"
                     /old_locus_tag="ABM27_RS04145"
                     /pseudo=""
     CDS             complement(13280..>14260)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1229: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129856.1"
                     /locus_tag="BN2145_RS04230"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04145"
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RIVLACAGPGIPPVVQVARDLRISADTVRKWRRRFLAERLDGLAD
                     EPRPGRPPTIGVDQVEAVVVATLEEIPKNATHWSRRSMAEHSGLSKSTVGRIWRKFQLK
                     PHLTDTFKLSTDPLFVEKVYDVVGLYFNPPEGAVVLSVDEKSQIQALDRSQPALPIMPG
                     MPERRTHDYVRDGLTTLFAAYVATGEVISSLHRRHRAAEFKKFLIKIDKEVPAHLQIHL
                     ICDNYGTHKTPAIRNWLARHPRFHMHFTPTGSSWINQVERWFGFLADQKIRRGAHKNVQ
                     ALEADIRAWVKDWNADPKPFIWTKTAEEILDSLAQFCRRISGAGH"
     gene            complement(14282..15007)
                     /locus_tag="BN2145_RS04235"
                     /old_locus_tag="ABM27_RS04150"
     CDS             complement(14282..15007)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057714.1"
                     /locus_tag="BN2145_RS04235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04150"
                     /product="DUF2470 domain-containing protein"
                     /protein_id="WP_029380938.1"
                     /transl_table=11
                     /translation="MRDNDTWTAEPATAQRARSVIAAAWSCAVTAEGGREELVGAHTMA
                     EDGRLFLEVAEDSPLLGAALCAPRGEPSAVLEFADVAPVPVRNRIRARLWLAGHLAVAD
                     GRLAFQPTRVVLRRHSGAVVVGLEEFAAAAPDPLATAEARLLTHLADCHGDAVERLTRL
                     VDAGSLHGAVRVRPLAVDRHGLTLRIERARSHGDVRLPFHVPADTVAQLTERVHVLLTQ
                     AAAAACPRAPRQQRTDAGN"
     misc_feature    15018..15036
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 34.2"
                     /tool="antismash"
     misc_feature    complement(15023..15041)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            complement(15093..15701)
                     /locus_tag="BN2145_RS04240"
                     /old_locus_tag="ABM27_RS04155"
     CDS             complement(15093..15701)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521290.1"
                     /locus_tag="BN2145_RS04240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04155"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_029380939.1"
                     /transl_table=11
                     /translation="MAANQGGRTRRRLSTEERREQLLAVGARLFSESPYDDVWIERVAE
                     IAGVSRGLLYHYFPAKRDFFAAVVERESERMLRMTAAVPGVPVREQLAAGLDAYLEYVA
                     AHADGYRAFHRADASGDEAVRRVYRRALAAQERQILAALAADPEFGPAFAERPGVRLAV
                     RGWLAFTTAVCLEWLRGPDPTREQVRDLCARALLGALAR"
     misc_feature    15753..15770
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.55"
                     /tool="antismash"
     gene            15820..17352
                     /locus_tag="BN2145_RS04245"
                     /old_locus_tag="ABM27_RS04160"
     CDS             15820..17352
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389325.1"
                     /locus_tag="BN2145_RS04245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04160"
                     /product="cytochrome P450"
                     /protein_id="WP_029380940.1"
                     /sec_met_domain="p450 (E-value: 2.3e-78, bitscore: 262.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGTTKGPAGDGPPRGFRSAELGWPELHRIPRPPHRLPLLGDVLG
                     AHGSTPVQDTLRYARQLGPIFRRRAFGKEFVFVWGAGLVADLADEARFAKHVGLGVANL
                     RPVAGDGLFTAYNHEPNWQLAHDVLAPGFSREAMAGYHRMMLDVAQRLTARWDRAQAAG
                     RAVDVPGDMTRLTLETIARTGFGHDFGSFEHSRPHPFVTAMVGTLSYAQRLNTVPAPLA
                     PWLLRRASRRNAADIACLNRTVDDLIRARRTAPGQGDLLDRMLETAHPVTGERLSPENV
                     RRQVITFLVAGHETTSGALSFALHHLSRQPEVAARARAEVDRVWGDTAEPAYEQVARLR
                     YVRRVLDETLRLWPTAPAFAREAREDTVLAGAHPMRRGAWALVLTPMLHRDPRVWGPDA
                     ERFDPGRFDAAAVRSRPPHTFKPFGTGARACIGRQFALHEATLVLGLLLRRYELRPDPG
                     CRLRVTERLTLMPEGLRLHLARRTAGVTPPPLEPAARDGGSAPRCPVRGAGD"
     gene            complement(17314..18144)
                     /locus_tag="BN2145_RS04250"
                     /old_locus_tag="ABM27_RS04165"
     CDS             complement(17314..18144)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389329.1"
                     /locus_tag="BN2145_RS04250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04165"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_162183938.1"
                     /transl_table=11
                     /translation="MSDHMADRAALRGDCARCFGLCCVALPFAASADFAKDKKAGTPCP
                     NLRDDHRCGIHARLRQQGYTGCTVYDCFGAGQRVSQITFGGRDWRSGPPEHARRVFDLF
                     PVVRQLHELLWYLTEALTLPAARPVHADLRRARLRTERLADGTPEELAALDVAAHRQEV
                     NVLLLRTSELVRAGTRGRKKNRRGADLMGARLRGADLRGADLRGALLIAADLTGADLRG
                     ADLIGADLRDTDLTDADLTGAFFLTQPQLNAARGGAETRLPESVARPAHWTAGR"
     misc_feature    18136..18150
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(18219..19124)
                     /locus_tag="BN2145_RS04255"
                     /old_locus_tag="ABM27_RS04170"
     CDS             complement(18219..19124)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389328.1"
                     /locus_tag="BN2145_RS04255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04170"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_029380942.1"
                     /transl_table=11
                     /translation="MSGTQTLAGRFEAHRRHLQAVAYRMLGSLAEAEDAVQEAWLRLSR
                     TDAAGQADGIGNLGGWLTTVTGRICLDMLRARAARREEPMDDRPAAFVPDPLLRPLPHD
                     DPEQEALHADAVGLALLVVLETLEPAERLAFVLHDMFAVPFDDIALVVERSPAATRQLA
                     SRARRRVRAATPAADPDLGRQKKVLEAFLAASREGDFDALLALLHPEVVLRADAGSVVR
                     GAAATKLVHGARAVAEQAAMFSPFAHAARPALVNGAIGAVTVIEGRPLAVMGVTVADGR
                     ITGMYILADPRRLARLDLPA"
     gene            complement(19177..19920)
                     /locus_tag="BN2145_RS04260"
                     /old_locus_tag="ABM27_RS04175"
     CDS             complement(19177..19920)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978056.1"
                     /locus_tag="BN2145_RS04260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04175"
                     /product="PIG-L deacetylase family protein"
                     /protein_id="WP_029380943.1"
                     /sec_met_domain="PIG-L (E-value: 1e-25, bitscore: 89.6,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPTITPLEPMPGDWQRALAVVAHPDDLEYGCSAAIAAWTDEGR
                     EVAYLLATRGEAGIDTLAPAECAVLREREQRASAAVVGVSRVEFLDHRDGVVDYGIALR
                     RDIAAAIRRHRPELVITLNHRDTWGGAAWNTPDHVAVGRATLDAAADAGNRWIFPELAE
                     QGLEPWNGVRWVAVAGSSTPTHAVDATPGLERAIRSLLEHRTYIEALTDEDPESYARAF
                     LTGSAKATGERFGDRPAVAFELFGR"
     gene            complement(19990..21294)
                     /locus_tag="BN2145_RS04265"
                     /old_locus_tag="ABM27_RS04180"
     CDS             complement(19990..21294)
                     /NRPS_PKS="Domain: Abhydrolase_1 (50-242). E-value:
                     6.9e-18. Score: 57.1. Matches aSDomain:
                     nrpspksdomains_BN2145_RS04265_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327690.1"
                     /locus_tag="BN2145_RS04265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04180"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_029380944.1"
                     /sec_met_domain="PF00561 (E-value: 8.2e-17, bitscore: 60.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVSYRQPGVVLTDRRFTVPLDHDDPAGETIELYAREVVASDKAH
                     QDDLPWLVHLAGGPGLGAMRPIGRQAWLDRALRDYRVLLLDQRGTGASTPATRQTLPLR
                     GGPAAQAEYLTHFRADSIVRDCEAIRREVTGGAPWTVHGQSFGGFCAVTYLSLAPEGLR
                     TVLVTGGLPSLDAHADDVYRAAYPRVERKVAAHYARYPQDVACARRIADHLLTHDVTLP
                     GGYRLTVEAFQSLGILLGTGDGSHRLHHLLADAFVRTPHGPELSDAFQEQARNLLSYAG
                     RPLYALVHEAIYGQGERPTAWSAERVRAEFPQFDAARSLAGDAPLLFTGESVHPWMFDC
                     DPALRPLRETAELLAARTGWRPLYDPARLAANEVPVAAAVYHDDMYVDTAHSLRTARAI
                     RGLRTWVTDEFEHDGVRVEGPRVLDRLLALARDEI"
     aSDomain        complement(20569..21144)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN2145_RS04265_Abhydrolase_1.1"
                     /evalue="6.90E-18"
                     /label="BN2145_RS04265_Abhydrolase_1.1"
                     /locus_tag="BN2145_RS04265"
                     /protein_end="242"
                     /protein_start="50"
                     /score="57.1"
                     /tool="antismash"
                     /translation="WLVHLAGGPGLGAMRPIGRQAWLDRALRDYRVLLLDQRGTGASTP
                     ATRQTLPLRGGPAAQAEYLTHFRADSIVRDCEAIRREVTGGAPWTVHGQSFGGFCAVTY
                     LSLAPEGLRTVLVTGGLPSLDAHADDVYRAAYPRVERKVAAHYARYPQDVACARRIADH
                     LLTHDVTLPGGYRLTVEAFQSLGILLGTG"
     gene            complement(21394..22419)
                     /locus_tag="BN2145_RS04270"
                     /old_locus_tag="ABM27_RS04185"
     CDS             complement(21394..22419)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994822.1"
                     /locus_tag="BN2145_RS04270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS04185"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_029380945.1"
                     /transl_table=11
                     /translation="MAQSVGIKDVARAAGVSVGTVSNVINRPETVATETRARVLSAIDR
                     LGYVRSESARQLRAGRSRIMGLLVLDMGNPFFVDVARGAERAARGAGLGVMVCNSAQSP
                     GEEAEYLSLFAEQRVRGVLLTPADATGRNIEGFRRHGIPFVLVDRVAEGATECSVSVDD
                     VAGGALAVRHLVDAGHRSFAYVSGPPGLNQVRDRRTGALNALAEAGLGPEALRELPTER
                     LDVAAGRDAGARLLGLADRPTAVFCANDLLALGVLQAMYAAGVGVPDDLAIVGYDDIEF
                     AAAAAVPLTSVRQPAVAMGALAAELLLEETESHGAGRTHEHRRVVLQPELVVRRSSLAA
                     R"
ORIGIN
        1 gctggcggga ggcgtcggcc gagctggccg ccgaggccgc cgccgacggg aactcccgtt
       61 caccgtaccg cggcctggcc cggttcgaac cgggcgacgc cgaactgttc ttcggccgcg
      121 accaactcct ggagcggttg accgagctga accacaagca ccgcttcacc gctgtcttcg
      181 gcccctccgg cagcggcaag tcctcgctgc tgcgcgccgg cctgatcccc cggctgcgga
      241 caccgcgtac cggcgaggac ggtggggacc gccccaccac gcccgcggcc gtacggatcc
      301 tcacgcccgg tgcggacccg ctgcgcacac acaccgaccg gctcatcccc gtacccgaca
      361 ccgacgccga cacctggctg gtcgtcgacc agttcgagga gctgtacacg ctcggcgccg
      421 ccccggccga ccgggacgcc ttcgtcgacc gcctcgtcac cgccacggac gccggcagcc
      481 atctgcgcgt cgtcatcgcg gtgcgggccg acttcctcgg ccgctgcacc gaacaccccg
      541 gcctcacggc cgcgttgcag gacgcgacgc tgttcgccgg gccgatgagc cgcgcggagc
      601 tgcgggaggc catcgtccgc ccggccgccg catacggcct gatcgtcgaa cgcaccctga
      661 ccgaccgtct cctggccgag gtcgaaggcg cgccgggcgg actgccgctg atgtcgcacg
      721 ctctgctgga gacctggcgc caccgcagcg gccgcaccct gaccgagacc gcgtacgagg
      781 cggccggcgg gctgcacggc gccgtcgtcc gtacggccga gcaggtgtac ggagagctca
      841 ccgcgcccca gggcgagctg gcgcgccgca tcctgctccg cctcgtcgcc cccggcggcg
      901 acggcacgcc ggacatgcgc cgccccaccg agcacgcgga actcgacttc ggcagccccg
      961 ccgacacccg agtggtattg gaacggctgg tccgagcccg tctcatcacc ttcgacgacg
     1021 gcaccgtcga tctagcccac gaagccctca tcaccgcctg gccccgcctg cgcgcgtggg
     1081 tggacgccga acgcgaccgg ttgcgtctcc accgtgccct ctccgaggcg gcccgcacct
     1141 ggcaggcact cggccgcgag gacgccgcac tctacgccgg ctcccggctg tccgccgctc
     1201 gcgacgcctt cccgcagagc ccggtgcggc cgcacggcac cgcccgcgcg ctcagcgagc
     1261 accacgaagg ccagtgcggt gacgaactca ccccgctgga gcggcggttc ctcaccgcct
     1321 cgctccggcg ccggcaccgt gccgcacgac tgcgccgtac cgtcgtggcc gtactcgccg
     1381 cgttcgctct gctcgccacc ggcaccgccg tcgtcgctct ccgggccggc gccacagcgc
     1441 aggccgaacg ggacaacgcc gtcttcggcc gcctcaccgc cgaggccgac cgtgtccggc
     1501 agacccacgc cgggctggcc gcccggctgg acgtcgccgc gctccgcatg cgctccaccc
     1561 cggacctgcg gacccggctg gcctcggacg cgggtcgggc actggccacc cggctacccg
     1621 cccacgacgg tgtcggcagc tccgtggcgt acgcgcccga cggccgcacc ctcgtcagcg
     1681 gcggccacga cggcaccgtt cggttgtggg acaccgccgc gtggccggga tcggcggacg
     1741 gaccagaagg catgggccgg ccgctgggcc ggccgctgcg cctgcgtacc ggaccggtcg
     1801 gcgcggtcgc cttcgcgccg ccgcacggcg acctgctggt ggccgccggc cgaggcggcg
     1861 ccatccagct gtgggacgta cgcgaccggg agcggccccg cgtcgtcggc cgaccgtcgg
     1921 tcagccacga cgggcagaac atcgtctcgg tcgcgttcgc ccccgacggc cggaggctgg
     1981 caaccgccgg cgacgacggc acggtacggc tgtgggacgt gcgcgacccg gaccgccccg
     2041 cgccgctcgg cgcacccgcc gaggccgacg cctccgatac aggcagcgtc cgcgctgtcg
     2101 cattcgcccc ggacgggcgc accctcgcca cggccggcta cgacggcgcc gtacggatgt
     2161 ggcggttcag cgaggacgac gggatcgcgc cgctcggccg gccgctgcgc gcgcacaccg
     2221 cacccgtctg ggcactggcc ttctcgccgg acggccggac gctggccacg gccggcttcg
     2281 acgagaccgt gcggctgtgg gacgccttcg gcccggaccg tcccgcgccg ttgggagagc
     2341 cgctcacccg gcacaccgcg cccgtgatgt ccgtggcctt cagtcccgac ggcgagaccc
     2401 tggcgaccgc gggcgaggac gactcggcca tcctgtggaa cgtggccaac cccgcgtacc
     2461 cgcagcagat cggggagccg ctggccggcc acacggaggc tgtgtgggag gtggccttca
     2521 gccgcgacgg ccgtaccctc gccagcaccg gggccgacgg cagcgtcctc ctctggcacc
     2581 ggccgccgac cgtcctcacc gacttcacca atccactcac cgccgtcgcc tacagccccg
     2641 acggccgtct gttcgccgcc gccagcaccg acgacgcgct gatccgcctg tgggacgtgg
     2701 atgcgcccgg ccacccgcgc cggattccgc gtgcgctcac cggccacgag gacgaggtgc
     2761 tggccgtcgc gttctccccg gacggccgca gggtggccag cggctcgaag gacggcacca
     2821 tacggctgtg ggacgtctcc gtgcccgaac gccccgcccc gctcggtgtc cccctggacg
     2881 cgcacgacgg cggcgcccgc accgtcgcgt tctccccgga cggccgcacg ctggccaccg
     2941 gcggaggcga cgacacggcg cggctgtggg acgttcgccg accggaccgc gtacggccgc
     3001 tcggcgaacc gctgcgcggc cacgcggacc ccgtcacctc cgtggccttc tcccccgccg
     3061 gccgcacggt ggccacgggc agcgaagacg gcacggtacg actgtggcac acaggcgacg
     3121 gggcgcgggc acggcctgcg ggggcaagcc tcaccgggca cgacgacacg gtcaacacgg
     3181 tggccttcgc ccctgacggc aggacactgg cgacgggcag cgacgaccgt acggtgcggc
     3241 tgtggaatgc tgcgcaagcg gaccgtgtgc gtccggtggg gaacgaactg gccgggcacc
     3301 gcggaccggt caggtccgtg gccttcgcgc ccgacggcaa gacactggca accggcagcg
     3361 gcgaccatac ggtccgcctg tggaacgtgg ccgatccggc ccgcgccgag cccgccggcc
     3421 aggaactcac cggccatctc aacaccgtca cctccgtcgc gttcagcccg gaaggcgaca
     3481 ctctcgcctc cgccagctac gacctgacgg cccgggtgtg gaccctggac gcgcaccgcg
     3541 cggcggacta cgtctgcgac cgcaccggtg gcgtgctcca ccgcgccgaa tgggaggagc
     3601 acctgccgca actccggtac cgggaggtgt gcgaggggcg ttagggggcg gtcagacgcc
     3661 gagcaaccgg ccggctgcgg gtaggcccga ccggtcgaag tcctccagga cgtgctcgag
     3721 ttcctcggac ggcggccgtg ccggggccag gtgggccgac atctcttccg atcgtccagc
     3781 atgccgccct gcctgtccct ccgcctcgct cccgcagtca ccgaccgcca gtaccgtccg
     3841 gctgacacca cggcgatccc ccccgcttgg acatccgacg gcctttctcc acgccgagac
     3901 cctgccttcg cggatctgcg ccggcaccgt ggaccggatc agcgcggcat gaattgttca
     3961 gccacccggc ccgcggtggt gaacaacgcc cgttggccgg gagagcccat ccaggggtgt
     4021 acacaccccg aagggcgaga tttttccgcg gcggaagagg gctgctgaac aatccggcga
     4081 acgctggaat cggtgccaag gagccatccg gcaccggtgc ccgtgatgcg gcagaccttc
     4141 cacgaagggg ggtctgccgg gtccttcggc gccgcatcgt gtcgtccacc gtccgtcacc
     4201 ctccactcat cgctactgga aggtatccgc gggcggtcga ttgggcggtc agctcctcgc
     4261 gacgggcacc gccgtgggga ggctcgtcat gacgaaggga atcccatgcc tcgcacaacg
     4321 gtcaaactgc tgggctcatt cgaagtggag agccaggggc gcatcatcac catctcgtcg
     4381 ggcaggcagc ggactctgtt gtcggtactc gcgctggaag cgggacagtt ggtcccgaca
     4441 gaacggctcg ccgaacacct atggggagag gagcctccac cgtcctcgcg caccaccatt
     4501 cgtggctaca tcctgcggct gcgccgggcg ctttccccac ggaccgcgcg ggaggcgcga
     4561 cccgtcatcg cttcggggag acacggttac cagttgttgc tgccgccgga gtccgtcgat
     4621 gtccaccagt tcaacagcct tgcggcccgt gccgccgccg cccgtgactc ggtcggggag
     4681 aacgacctgc tccgcagggc cctgtcgctg tggcgtggac cggcattgtg cgacgttccg
     4741 ggtgacgcac tgcaccgtgg agttctgccc gcactagagg agcggcggct ccaggtgctc
     4801 gagcgcagtg tcgaagtcgc cctcgccagg ggcgagcacg cgcaagcagt cgtcgagctg
     4861 cggcggctgg tcgccgagca tccccttcgg gacggcctgt ggggccagtt gatgctggca
     4921 ctctacggag cgggccacca gtccgaggcc gtgtaccaat acgagcgttg ccgcggcatc
     4981 ctcgccgagt cgctcggcgt cgacccggat ccccgggttc gcgaactcca ccgcctgatg
     5041 ctggtggagg acccggcgct cggtgccgta cgacagtcgg cgccgccgtt gcccccgtcc
     5101 gggccgggac ggaacacgga ggcccggtcc gcgtcggcga tgcggcagga cctgccctcg
     5161 caccggctcc ccgaggcccc cgccctcttc atcggacgcg agcaggaaca agcggcgctc
     5221 tcggtgatcg cgggcgagga gtacccagga ggcacccggc cgatcatcat cgacggcgcc
     5281 gccggtgtgg gcaagacggc cctcgccctc gcatgggcgc accgggcggc cgaccggttt
     5341 cccggtgggc ggttctacgt cgacctccag ggtttcggac cggcggacgc tctcgatccg
     5401 gctgacgctc tgatggtggt tcttgccgcc ctcggcgtcc ctccgggccg gctgcccgcc
     5461 ggggtgcccg cgcggcaggc gcttctgcgc acccgtctga agggccggca agccctgctg
     5521 ctgctggaca acgcggtcga tgccgagcag gtgcgccctc tgctcaccgg ctgtgcgacc
     5581 gtgctggtga ccagccggga tcagatgcgc ggtctggtcg tctccgacgg cgcgcgacgc
     5641 ctcacgctgg accggctgac gccggttgcg gcacagcacc tgctcaccgc tctcatcgga
     5701 cacgagcgcg gtggtgcgca ggccgaagcg ctcggtgact tggcaagcct gtgcggttgt
     5761 tctcctctgg cgctgcgcgc gatcgctgag tccgcgaccc gctggaacgg gctcccgctc
     5821 gaagaactgg ccgcaggact gcgcggcgcc ccttgctggc tgtcctctct tcgcaccggt
     5881 gaggacagga ccgacccggt gtcggtgctc agctggtcct acgacaagct gggtcccgcc
     5941 cccgcccggc tgtaccgcgc cttcggttca taccgggaac gccgagtcac cgcggtggcg
     6001 gcggcagggt tcgccggggt cccggtgtcg gcggcgacgg aacaactcga tgcgttggca
     6061 cgtctgcacc tggtggagga gcgagtgccc ggctgcttcg acctcgatga actgcccagg
     6121 gcgttcgccc gcctgctgcc gcggacctcg gacggggcgg ggtgacctga ggtggatggg
     6181 gcgcggcccg gggtcagggc ggcgccccgg tctcccccca gtggcccacc aggtcggcgt
     6241 aggtggcgca agtccgcagc agttcccggt gcgtgccgct gtgcaccgtg cccgcatcca
     6301 ccaccaggac ctgctgtgcc cgggcggctg agggcatccg gtgggcgatc accacgagcg
     6361 tgccgccgcg ctgcgcgaag gcgcgctcca cacgctgctc ggccgcgatg ccgaggtggc
     6421 aggtcgcctc gtcgaggatc acgatcctgg ccggggacag atagaccctg gccagggtca
     6481 gcaactgccg ttgcgcgggg gagagcaggt cgggccgcct cagctcgccg tcgtatccgc
     6541 ccagctccgc caggagcgcg gtgatgtcca gggcttcgat cgcccggtcg aggcggtcgt
     6601 cgtccgcctc cggcgcgagg tatccgaggt tgtcccggac ggtgccggcg aagacatacg
     6661 cttcctgagg taccagtgcg atgctgcggc gaagccacgc ggggtcgagg tccggcagcg
     6721 gtacaccgcc caacagcact tggcccgact cgggacgctc cagcccgcac acgagatcgg
     6781 ccagtgtcga cttgcccgcg ccgctcggtc cgacgaccgc caggtggccg cctgcgggaa
     6841 gagtgacgca gacccggtcg agcacgggcg ggtcggtccc ctcaccccgg cggaaggtca
     6901 ctgcacgcag ggtgagctcg atgtccgggg gcacgggctc gggggcggcg ggccggcgtc
     6961 ggcaccgccc gtcagtgccg gtccccggcg cactctccgc cacccgcccg ggcttcggct
     7021 cccggtgata ttcggtgagc ctggccagca ccgtgccgag ttccaaggcc aggttgccca
     7081 ccgactggac cagggagcgc agtgcgggct cgagagagga gaccaggtag gtgaccgctc
     7141 ctaccaactc gccgggtgta agggcaccct gcgccgacag ccagggcgcg gtcaccagca
     7201 gggcgatcag cgggaggcgg gcgccgagcg cgacggcgcc gaccctggcg ccgctcgccc
     7261 gggcgaccgc ggcggcggcg tcggcctgcg cgtccacggc gtggtcggtg tcttcccggg
     7321 cccgcctggt ggccccgcac gctacgacgt ctcgcaggcc ctggactctc tgcgcgatct
     7381 gctcggtcat gtgctcgtcg gcagccagtg acgccgagta gcgcaaccgc caggagcggg
     7441 aaagccgcac caccaccacc actccgaccg tgagcgcggg cagcagcgcg agcagtccgc
     7501 tgacgggcgc caggcttacc actccgacga gagccgccgc cgctgtcaga cccgtcgagg
     7561 gcgctgacat caacagcgcc gccaggattt gcctggcgtt ctccgtctgg ctggtgagcg
     7621 ctgtgaccga ctcgcctccg gaacttacgc ctccggccac cgcgcggcgc agcccgccgg
     7681 ataccgttgt ccgcaccagg tggtcgcgca ccgcctcggc cacagtcgcc atcggggcca
     7741 tcgcgcgcca tgcggcgaag gaacccactg cgagcgccgc gccgtacccg ccgagcgtca
     7801 ggaacccggt gaccgcgtcg tcggccagga agccgtggtc tacggcatgg gccaccaacc
     7861 tgccggagag cagcaccgga agagccccga gcagcgacca cgcggcgatg gagtgcagtt
     7921 cccggcggtg ccgggccgcc accgggcgca gtagctgcca tctggagtcc ttcatgtccg
     7981 tgtcctgact gtcgctgcgg tcggaccgtc ggagctgtgt gctggtttcg agggggaggc
     8041 tgtgtcccct tcctccccac accggaagat cgctcggtag gccgggtccc gcagcagcac
     8101 agcgtgcggc gccagcgcgc ggagggtgcc ggcgtccagc caggccacca gatcggcacg
     8161 ggccgccgtg gccgctctgt gggtgacgac cagccgggtg cggtcggcca gcaggcgccc
     8221 aagcgcggta ccgactcgcg cctcggtcac ggtgtccacg ctggagagcg cgtcgtcgag
     8281 gatcaccaga cgggcatcgc ggcaagccgc ccttgccaag cccaggcgct ggaactcgcc
     8341 gccggacagt cgcagccggc gcaccggcgt ctccagccct cggggcagcc gcgctgtgaa
     8401 ctcctcggcg tgcacggcgc gcaggctcgc cgccagacgc ccggcggcgg gtggccggtc
     8461 ggtataggtg agcgcgtcgc gcagggtctc gcccaccagc aacggccgtt cgaaggcata
     8521 ggcgatcgcg tcgcgcagtt ccccgggtcg cacctcgtgc agggggacat cgtcgagcag
     8581 gacagtcccc tgatcggcgg ggaccagtcc cccggccacc ctggcgagcg cggatgcgcc
     8641 cgagtccggc gggcctacga gggccacttc ggtgccggcg ggaacggtga agtcgatccc
     8701 gcgcagcacg ggccgtccct ttgcgcacag tgccacccca cgcagctcca gtcgccctgg
     8761 tcctggtgtc agcgggcgcc ggcccccggc cgcggttccc gctcggagca cggcgcccac
     8821 gcggtcggcg ccggcccgcg ccctggccag acgggcgaag accgcggtct gtttcatcag
     8881 ccccgtggcg agggcgagat acccggcagc agccagcatc tccccgtggc tgatccggcc
     8941 gtgcaacaaa ctgtgcccgg cgagcgcgag taccccgagc tgcatcaccg gcatgatcag
     9001 gccgatccgc caggccgcgc cgcgctgcgc ggcccagaat ccacgcccgg ctgcggtgag
     9061 ccgggaaagc ggcgtcagga tgcgggccgt ctcgcggtcg gccgttcctg aggcgcggat
     9121 cgtccgcagt ccggtcagcg cgccgacgaa ccgtgaggag aggtcgcttt gggcctcctg
     9181 gtactcgagg gtcacccggc ccgccagtgg gacgaaccaa cgcagcagcc accaggtcag
     9241 cagcacgcct gcgaggaaga acaggccgag cccgacgtcg atgagaaaga gcgcgaccag
     9301 cccgcccacc gaggtgccca acaaggacat cgtgctcacc agcacgggag tgacggccgc
     9361 agcgccggcc gtcgactcca tgactcggct gagcacgtcc ccggtgtcga acctcgcctg
     9421 cgcggtgaca ccgagatccc acacacggtg cagcaacctg cggcgcagtg cccgcgcgcc
     9481 ccgagcctcg gcggtcgtct gcaaagtctc acgggccgct tcgcaggctg tcgacaccgc
     9541 gagcaccgcg cacgccgaca ggacctgcct ccaagcggta cgccccgtga cgaccgcgtc
     9601 cacggcagcg gccagcgccg cgggcagcac caggcgggcc agcgggtcca aggcggccac
     9661 cgcgagcagg cccgcgctgt ggccgccggc tgcgcgcacg gtctgcgcca ggagccggtc
     9721 ggtgtaccgc actggtgagc ctcctcgtcg aagaacggcg tgaaccggtg cggtgcggcg
     9781 gacgccgtgc gtccgccgca ccgctgtggt cagaccctca tccgcgcaat gtccgcggca
     9841 tcaggtccag tagtcgaagt gccagttgat ctcctcgtcg ttgcgcaccc cgtacaggcc
     9901 cgtctcctcg gcgaacgcgc ccaatccgta caccgcaggg gtctcgtacg gcgtcttctc
     9961 gtcgtgctcc atggggttct ccttccgttg tcccgccgcg tcaacgcggc gactcactcc
    10021 tggccgaccg ggtctccggt cgacccccgg ccgctgaccg gccgagtcct tgtccgcggt
    10081 gtccgaagcc ccgggccgga gccggctcca ccgcgaaaaa cctccggtag caggcgctgt
    10141 cgaccggctc atcgaccatc tcgccggcca cctcgatcca ggcgtgcgcg cggaagggcg
    10201 gggcggccac cacccccacg caccaggtgg gccaggtccc gcgtgacctg cacagcagtg
    10261 ccaccgcaat cgacctgggc aggcatgccg agggcccgca gcaccgcgtg ctgacgctga
    10321 gcacttcgtc cctggcctgt cgcgcctccc catggccagc ggcgcgtgtg cccgcgctga
    10381 acgccgtcat cacacgccgg atgcactgcg gtgagcgctt ggccagcact cgcgccacca
    10441 gcacgagcag gcgcacccgg atccgcaccg cgagtcgtgg ccgcagtggc cggctgggga
    10501 gtacaggagt cgtcaccgtg tcatcacctg gagctgtacc agtctctcca ccagcgcgag
    10561 cgtgtctctg cgggcggtct cctcgttcac gtcgaaggcg cgggtgagcg ccacgaccgc
    10621 ctcctcgaca ccgcctccgt ctcgtagcct ggccacgatg gtcgatgcgc tcggtgtcaa
    10681 ctgccagtat tcaccggtac gttcgtcgag caggaccatc ccgtactcgg tctcgaccac
    10741 ggagacctgc tcggccatga gtggtgtcat gactcattcc tcaagggccc gggcgggccc
    10801 ggactcggac gggagcgcgt gtgcgacacc gggcgtcgca gcgcatccac gtacctggtt
    10861 gcgaaggaac agggcacagt tgacggtggt gaccaggtgg ccgtccggtc ggtgacccgc
    10921 ctgcggtctg ttgtgccggc gcagtgctcc gatctcgatg attccgaggt cggtgagcgg
    10981 agaagcttcg cacaggtcga gcagctccgc gtggtgggct gcgtatccgc gcacgctctg
    11041 cgggctgccc ccggcccgcg tcgtccggac caggaagtca tccggcagca ggccgcgcat
    11101 cgcctctttc atcaagggct tgatctccag cggagacact cgctcctcgc gcctgacggc
    11161 caggcacgcc tccactaccc ggtcgtcgag cagcggtgcc tcgaacggca ggcccgcgtc
    11221 cgcacccagt tgactcgtgc cgcgcaccac gcgggcgccg tcccgcacca tcgccagctc
    11281 ggaatggtcc gcacggccct ggcccaaggg ctcgaccgtg gcactcagct cctcgatcct
    11341 gccgcgtacc gcccgcagcg catcctgcgt catccacagc ggccaggcga acggctggtc
    11401 ccagtcgaat ccgatgcggt ggtccttcga cggctccctg cgtgccgagg cggcggcggc
    11461 gtgcagccac tgcgcgtagc cgcgccggtc aagcaagcca cgcgctgtcg tggcgatcga
    11521 ttcgccgctc agcatgcggt tggtccgggc tctctgccag gccagccagg gccgactacg
    11581 aaagagggtg tgctcccaag cgggcagccc gcgcagcaca tggtcgccgc ccaagccgtt
    11641 cagatacatc cgcgccgtat ggcttagggc gtcctcgatg ttcgcccgca tgcgcggcgc
    11701 cgcgaggcag gcggctgtcg gctcgtccca ccgggtgtcc acctcggaca ccccttcgaa
    11761 gaagccgggg agcttgtcga gcgacagcac gcggtgctgc accgacggca tcaccgccag
    11821 agcccgcctc gcccagcgca ggtcgtccgt gccgcctgga tccgcgttgt acgcggtcgc
    11881 cgccacgatc cgggcggagc cctgagccgc gaaccaggtg atcggggtgg agtccagacc
    11941 gcccgagatg tcgcagtgca ccacgccgcc cgcctgggta cggaccgcaa ccgcgtccgc
    12001 caacgcggta cgcagcagtc gggcgccgtc ccggcgcgtg aggtgcggct cgggacgccg
    12061 ccaccatcgc cgcatcatcg cgccgcggcc gtccgcgtcg atgcgcaggt acgactcggg
    12121 cggcacgtgg tccacgccct gccacaacgg ttgttcgccg agcgggtggg gcagggttcg
    12181 cagcagccgg atcgccagtg tggtcgggtc gtaccgatgc cctcccaggt cggccaggac
    12241 gtcggcccgg tcggaagcga cggtgatgcc gccgagaacg gtgtggaaga cccggcgcac
    12301 cccggcggcg ctgccctgga cgcgcagccg cccaccgacc gaggccgcca ggtggaaccc
    12361 gcctgccagc gtgtgagaaa gagcatcgaa cgcctcaacg ctgcccgcgc gttccgctgc
    12421 cgtgcgcagc ccggccggtg tggccgagga gtagccgaga acagcgaccc ggtcggcccc
    12481 cgcttcaccc gtgacgatct gttcaccagg cagtgcgacg accagccacg gcctgcccga
    12541 ggcgtgcggg atccggcgcg ttcccgtgtc gggcagccgg tccgcgagcg ccgccgcctc
    12601 gtcgctgtcc ggcagcatca cgaagaacca ccgcgggacg cagggttcca tgacttccct
    12661 cctccactag gcacggccgg agccgggcct gtcacaggcg tcggccaccc ggcgccatca
    12721 ggtgacacca ccgtcgcagc gccctgtggc ggcagcgtgg ttcccgggtt gtcatccggt
    12781 tgtccgtgcg cagcgcgctg ctgggcatcc cggcccaact cccggtatgg aaggtccccc
    12841 gctccaagag cgcgaggacc ttccataccg ggcacttcgg cccggacggg tatggctgca
    12901 cggcatccgg ttcttattgc ggtccggtgc agccggcggc gtccttcgac ctgggcgctc
    12961 gacccggagc accaacacgg gaggcgcggc gtgaggccga gggtggagcc tcgcacgcga
    13021 cctgctccgc cggggcagtg gatcgccgac gcccggcggt tctacgcccg cggggacacc
    13081 gcgggaacat ggacgaggac tgcgtcgagc agccagtgcc gcggcaggcg acgttcgttc
    13141 gcccgtcgag gagcggcgtc cgctgcgcgt tctcggtgtg ccggccggga gccttcgcgc
    13201 tggacggacg cgggttcggt cggtgcggcg ggaacgcgtg ccgggcgtcg ccacggggcg
    13261 gacgttgcct gccggagcac tagtgtcctg cgccggagat tcgtcggcag aactgggcga
    13321 gggagtcgag gatctcctcg gcggtcttcg tccagatgaa cggcttgggg tctgcgttcc
    13381 agtccttgac ccaggcacgg atgtcggctt cgagggcctg gacgttcttg tgtgcgccgc
    13441 ggcggatctt ctggtcggcc aggaagccga accaccgctc gacttggttg atccacgagg
    13501 agccggtcgg ggtgaagtgc atgtggaagc gtgggtgtct ggccagccaa ttcctgatgg
    13561 caggcgtctt gtgggtgccg tagttgtcgc agatcaggtg gatctgcagg tgcgcgggta
    13621 cctccttgtc gatcttgatc aggaacttct tgaactccgc tgcccggtgc cggcggtgca
    13681 gggagctgat gacctcgccg gtggcgacgt acgcggcgaa cagggtggtc aggccgtcgc
    13741 ggacgtagtc gtgggtgcgc cgctcgggca tgcccggcat tatcggcagc gccggctggg
    13801 agcggtccag ggcctggatc tgggacttct cgtccaccga gaggaccacc gcgccctcag
    13861 gcggattgaa gtacaggccg acgacgtcgt agaccttctc cacgaacaac gggtccgtgg
    13921 acagcttgaa ggtgtccgtc aggtgcggct tgagctggaa cttccgccag atgcggccca
    13981 ccgtggactt cgacaggccg ctgtgttcgg ccatcgacct gcgcgaccag tgcgtggcgt
    14041 tcttcgggat ctcctccagc gtggcgacca cgaccgcctc cacctgatcg acaccgatcg
    14101 tgggaggccg acccggccgg ggctcgtcgg ccaggccgtc cagccgctcg gccaggaacc
    14161 gccgccgcca cttgcggacc gtgtccgcgg agatccgcag gtcccgggcc acctggacga
    14221 cgggcgggat gccaggaccc gcacaggcca acacgatccg acgaactatc ggcgcaagac
    14281 actagttccc ggcgtccgtg cgctgttgcc gcggggcccg cgggcaggcg gccgcggccg
    14341 cctgcgtgag cagcacgtgc acgcgctcgg tgagctgggc gacggtgtcg gcgggcacgt
    14401 ggaagggcag tcgtacgtca ccgtgggagc gggcgcgctc gatgcgcagt gtcaggccgt
    14461 gccggtcgac ggcgaggggg cgtacgcgga ccgcgccgtg gaggctgccc gcgtccacga
    14521 gccgggtgag gcgctcgacc gcgtcgccgt ggcagtcggc gaggtgggtc agcagccggg
    14581 cctcggccgt ggccagcgga tcgggcgcgg cggcggcgaa ctcctccagg ccgacgacca
    14641 cggcaccgga atgccggcgc agcaccacgc gcgtcggctg gaacgccagc cggccgtccg
    14701 cgacggccag atggccggcg agccagagcc gggcgcggat gcggttgcgg accgggacgg
    14761 gtgcgacgtc ggcgaattcc agcaccgcgg acggctcccc acggggcgcg cagagggcgg
    14821 ccccgagcag cgggctgtcc tcggccacct ccaggaacag ccggccgtcc tcggccatgg
    14881 tgtgtgcccc gaccagctcc tcgcggccgc cctccgcggt caccgcgcag gaccacgcgg
    14941 cggcgatcac ggagcgggcc cgttgcgccg tggcgggctc ggccgtccag gtgtcgttgt
    15001 ccctcatccc gtcctcctta ggtaaggctc acctaaccta tcggagatcg agggtggggc
    15061 caaccacacc cctcgctttc tcgagggacc tgtcagcgcg cgagggcacc cagcagggcg
    15121 cgcgcacaca gatcgcgcac ctgctcccgg gtgggatccg ggccgcgcag ccactccagg
    15181 cacaccgcgg tggtgaaggc cagccagccg cgcaccgcca gccgtacccc gggccgctcc
    15241 gcgaaggccg ggccgaactc gggatcggcg gccaaggcgg cgaggatctg ccgttcctgc
    15301 gcggccagcg cccgccggta gacccgccgc accgcctcgt cgcccgacgc gtcggcgcgg
    15361 tggaaggccc ggtagccgtc ggcgtgcgcc gcgacgtact ccaggtaggc gtcgagaccg
    15421 gcggcgagct gctcgcgcac cgggacgccc ggcacggcgg ccgtcatccg cagcatgcgc
    15481 tcgctctcgc gctccacgac ggccgcgaag aagtcgcgct tggccgggaa gtagtggtac
    15541 agcaaccccc gggagacccc ggcgatctcg gcgacccgtt cgatccacac gtcgtcgtac
    15601 gggctctccg agaagagtcg cgccccgacc gccagcagct gctcccggcg ctcctcggtg
    15661 ctgagcctgc ggcgcgtgcg cccgccctgg ttcgcggcca tgcccgcact gtacttgacg
    15721 ccgattcagc aacgggacga gactgaagcg cgttgttgaa cccgtgtaca gcaccctacg
    15781 ggcgtcgcga agcgccgccg gatcgaagga gatcgcgcca tggcggggac gacgaaagga
    15841 ccggccgggg acgggccgcc gaggggattt cgcagcgccg agctgggctg gcccgagctg
    15901 caccgcatcc cgcgtccccc gcaccggctc cctctgctcg gcgacgtgct cggcgcgcac
    15961 gggagcactc ccgtgcagga caccctgcgc tacgcgcggc agctcgggcc catcttccgg
    16021 cgccgcgcgt tcggcaagga gttcgtgttc gtgtggggcg ccgggctggt ggccgatctg
    16081 gcggacgagg cgcgcttcgc caaacacgtc ggcctcggag tggccaatct gcggccggtg
    16141 gccggggacg ggctgttcac cgcgtacaac cacgaaccga actggcagct cgcccacgat
    16201 gtgctggccc cgggtttcag ccgcgaggcc atggcggggt accaccggat gatgctggac
    16261 gtggcgcagc ggctgaccgc tcgctgggac cgcgcccaag cggcgggccg ggcggtggac
    16321 gtgccgggcg acatgacccg actgaccctg gagacgatcg cccgcaccgg gttcggccac
    16381 gacttcggct ccttcgagca ctcccgcccg caccccttcg tcaccgcgat ggtgggcacc
    16441 ctctcctacg cccagcggct caacaccgtg ccggcgccgc tcgccccctg gctgctgcgc
    16501 cgcgcgagcc gccgcaacgc ggccgacatc gcctgcctca accgcacggt cgacgacctg
    16561 atccgcgccc gccgcaccgc gcccggccag ggggacctgc tcgaccggat gctggagacg
    16621 gcccaccctg tcaccggaga gcggctgtcg cccgagaacg tccgccgcca ggtcatcacc
    16681 ttcctggtgg cgggccacga gacgacgtcg ggcgcgctct ccttcgccct gcaccacctc
    16741 tcccggcagc ccgaggtcgc ggcccgcgcc cgcgccgagg tcgaccgggt gtggggggac
    16801 acggcggagc cggcctacga gcaggtggcc aggctgcgct atgtgcgccg ggtgctggac
    16861 gagacgctgc ggctgtggcc gaccgcgccg gccttcgccc gggaggcgcg cgaggacacg
    16921 gtgctggcgg gcgcccatcc gatgcggcgc ggcgcctggg cgctcgtgct cacgccgatg
    16981 ctgcaccgcg atccgcgggt gtggggcccg gacgccgagc ggttcgatcc cggccggttc
    17041 gacgccgcgg ccgtacggtc acgtcccccg cacacgttca agccgttcgg gacgggcgcg
    17101 cgggcgtgca tcgggcggca gttcgcgctg cacgaggcga ccctggtcct cgggctgctg
    17161 ctgcgccgct acgagctgcg gcccgatccc ggatgccggc tgcgggtcac cgagcggctg
    17221 acgctgatgc cggagggact gcggctgcac ctggcccggc ggaccgccgg tgtcacgccc
    17281 ccgcccctgg agccggccgc ccgcgacggc ggctcagcgc cccgctgtcc agtgcgcggg
    17341 gcgggcgact gactccggca gccgggtttc ggcaccgccc cgggcggcgt tgagctgcgg
    17401 ctgcgtcagg aagaacgcgc cggtcaggtc ggcgtccgtc agatcggtgt cgcgcaggtc
    17461 cgcgccgatc aggtccgcgc cccgcaggtc cgcaccggtc aggtcggcgg cgatgagcaa
    17521 ggccccgcgc aggtccgcgc cgcgcaggtc ggcgcccctg aggcgggcgc ccatcaggtc
    17581 cgctccgcgg cggttcttct tccggccccg cgtgccggcg cggaccagtt cgctggtgcg
    17641 cagcaggagg acgttcacct cctgccggtg cgcggccacg tccagcgcgg ccagttcctc
    17701 aggagtgccg tcggcgagcc gctcggtgcg cagccgggcg cggcgcaggt cggcgtggac
    17761 cgggcgggcg gccggcaggg tgagcgcctc ggtcagatac cacagcagtt cgtgcaactg
    17821 gcgcacgacc gggaacaggt cgaacacgcg gcgggcgtgc tcgggcgggc cggaccgcca
    17881 gtcccgcccg ccgaaggtga tctgcgagac ccgctgcccg gcgccgaagc agtcgtagac
    17941 cgtgcagccg gtgtagccct gctgccgcag ccgcgcgtgg atgccgcagc ggtggtcgtc
    18001 acggaggttg gggcacgggg tgcccgcctt cttgtccttc gcgaagtccg cggaggcggc
    18061 gaacggcagg gcgacgcagc acagtccgaa gcaccgcgcg cagtcgccgc gcagcgccgc
    18121 ccggtccgcc atatgatccg acatgtcgat catcatagaa accagcgggt cgtggaagcc
    18181 acgggcccgc cgcagccggc gcgtaccggc gggccacctc aggccggcag gtccaggcgg
    18241 gcgagccgcc gcggatcggc caggatgtac atgccggtga tccggccgtc ggcgacggtg
    18301 acacccatga ccgccagcgg acgcccctcg atgacggtga ccgcgccgat cgcgccgttg
    18361 accagcgccg gccgcgcggc atgggcgaac ggggagaaca tggccgcctg ttccgccacc
    18421 gcccgggcgc cgtggaccag cttggtcgcg gcggcacccc gtacgacgga cccggcgtcg
    18481 gcgcgcagga cgacctccgg gtggagcagg gcgagcagcg cgtcgaagtc tccctcccgc
    18541 gaggccgcca ggaaggcttc gagtaccttc ttctgccggc cgaggtcggg gtcggcggcc
    18601 ggggtggcgg cgcgcacccg gcgccgggca cggctggcga gctggcgggt ggcggccggg
    18661 ctgcgttcca ccaccagggc gatgtcgtcg aacggcacgg cgaacatgtc gtgcagcacg
    18721 aacgccagtc gctcggccgg ttcgagggtt tcgaggacca ccaggagggc caggcccacc
    18781 gcgtcggcgt gcagcgcctc ctgctcgggg tcgtcgtgcg ggagtggccg gagcagcggg
    18841 tccgggacga aggcggcggg acggtcgtcc atcggctcct cacggcgtgc ggcgcgggcg
    18901 cggagcatgt cgaggcagat gcggccggta acggtggtca gccagccgcc gaggttgccg
    18961 atgccgtccg cctggccggc cgcgtcggtg cggctcagcc gcagccaggc ttcctggacg
    19021 gcgtcctcgg cctcggccag cgagccgagc atccggtagg ccaccgcctg aaggtgcctg
    19081 cggtgcgcct cgaaccgtcc ggccagcgtc tgcgtaccgc tcatgtggtt cccctcaccc
    19141 gttctccccg catgtgctct ccccctcccc cgccgcctac cggccgaaca gttcgaaggc
    19201 caccgcgggg cggtcgccga accgctcccc cgtggctttg gcactcccgg tgaggaaggc
    19261 gcgggcgtag ctctcggggt cctcgtcggt cagcgcctcg atgtaggtgc ggtgttccag
    19321 cagggagcgg atcgcgcgct ccaggcccgg ggtggcgtcc acggcgtgcg tgggcgtact
    19381 ggacccggcg acggcgaccc accgcacgcc gttccagggt tcgaggccct gctcggcgag
    19441 ttcggggaag atccaccggt ttccggcgtc ggccgccgcg tcgagggtgg cgcggccgac
    19501 ggccacgtgg tccggggtgt tccaggcggc gccgccccag gtgtcccggt ggttgagggt
    19561 gatcaccagc tcgggccggt gacggcggat cgcggcggcg atgtcgcggc gcagggcgat
    19621 gccgtaatcg acgacgccgt ccctgtggtc gaggaactcc acccgcgaca cgccgaccac
    19681 ggcggcgctc gcccgctgtt ccctctcccg caggacggcg cactcggcgg gcgccagcgt
    19741 gtcgatgccc gcctcgcccc gggtcgcgag cagataggcg acctcgcggc cctcgtcggt
    19801 ccaggccgcg atcgccgcgg agcagccgta ctccaggtcg tccggatggg ccaccaccgc
    19861 gagggctcgc tgccagtcgc cgggcatggg ctccagcggt gtgatcgtcg gctcggtcat
    19921 gtccgcagac tagcccgcgc ccgagccacc gcacctccgg gtttcccccc gtcgcaccat
    19981 cgccgcccct cagatttcgt cgcgggcgag cgcgagcagc cggtccagga cgcgggggcc
    20041 ctcgacgcgg acgccgtcgt gctcgaactc gtcggtcacc caggtgcgca ggccccggat
    20101 cgcgcgggcc gtccgcaggg agtgggcggt gtcgacgtac atgtcgtcgt ggtagacggc
    20161 cgccgcgacc ggcacctcgt tggcggcgag gcgggcgggg tcgtacaggg gccgccagcc
    20221 ggtgcgggcg gcgaggagtt cggcggtctc gcgcagcggg cgcagcgccg ggtcgcagtc
    20281 gaacatccac gggtggaccg actcgccggt gaagagcagc ggggcgtcgc ccgccaggct
    20341 ccgggcggcg tcgaactgcg ggaactcggc gcggacccgc tcggccgacc aggcggtggg
    20401 gcgctcgccc tggccgtaga tcgcctcgtg gaccagggcg tacagggggc ggcccgcgta
    20461 cgacagcagg ttccgcgcct gctcctggaa cgcgtcggac agctcggggc cgtgcggggt
    20521 gcggacgaag gcgtccgcca ggaggtggtg caggcggtgg ctgccgtcgc cggtgcccag
    20581 caggatgccg agggactgga acgcctcgac ggtgaggcgg tagccgccgg gcagggtcac
    20641 gtcgtgggtg agcaggtggt cggcgatgcg gcgggcgcat gcgacgtcct gcgggtagcg
    20701 ggcgtagtgg gcggcgacct tccgctcgac gcgggggtag gcggcccggt agacgtcgtc
    20761 ggcgtgggcg tcgagcgagg gcaggccgcc ggtgacgagg acggtccgca gtccctcggg
    20821 ggccagggac agataggtga cggcgcagaa gccgccgaag ctctggccgt ggacggtcca
    20881 gggggcgccg ccggtgacct cgcgccggat cgcctcgcag tcccggacga tggagtcggc
    20941 gcggaagtgc gtgaggtact cggcctgcgc ggcggggccg ccgcgcagcg ggagcgtctg
    21001 ccgggtggcg ggggtggagg caccggtgcc gcgctggtcg aggaggagga cgcggtagtc
    21061 gcgcagggcg cggtcgagcc atgcctgcct gccgatgggc cgcatcgccc cgaggccggg
    21121 gccgccggcg aggtggacca gccagggcag gtcgtcctgg tgcgccttgt cgctcgcgac
    21181 gacttcgcgc gcgtacagct cgatcgtctc ccccgcgggg tcgtcgtggt cgaggggcac
    21241 ggtgaagcgg cggtcggtga ggacgacgcc gggctggcgg tagctgacgc tcaacggggc
    21301 tcccggaacg gatggaactt tcggcgccca gttcagcaca cggccccgcg gccgcccgct
    21361 ccgggacccg cggggggtcc ggccgggcgg cggtcagcgg gcggccaggc tggagcgccg
    21421 taccaccagt tccggctgga ggacgacccg gcggtgctcg tgggtccggc cggcgccgtg
    21481 cgactcggtc tcctccagca gcagctcggc ggcgagcgcc cccatggcga cggcgggctg
    21541 ccgtacggag gtgagcggga cggccgccgc ggcggcgaac tcgatgtcgt catagccgac
    21601 gatcgcgagg tcgtcgggga cgccgacacc ggcggcgtac atggcctgca ggacgccgag
    21661 ggcgagcagg tcgttggcgc agaagacggc ggtcggccgg tcggccaggc ccagcaggcg
    21721 ggcgccggcg tcgcggcccg cggcgacgtc gagccgttcg gtgggcagct cgcgcagcgc
    21781 ctcgggcccg aggccggcct cggcgagcgc gttcagggcg ccggtgcggc ggtcgcgcac
    21841 ctggttgagg ccgggcgggc cgctgacgta cgcgaaggag cggtgcccgg cgtccaccag
    21901 gtgccgtacc gcgagggcgc cgcccgccac gtcgtcgacg gagaccgagc actcggtggc
    21961 gccctcggcg acgcggtcga cgagcacgaa ggggatgccg tgacgccgga agccctcgat
    22021 gttgcggccg gtggcgtcgg ccggggtgag cagcacgccc cgtacgcgct gctcggcgaa
    22081 gagcgacagg tattcggcct cctcgcccgg gctctgggcg ctgttgcaga ccatcacgcc
    22141 gagcccggcc ccgcgtgcgg cccgctcggc accgcgggcc acgtcgacga agaacgggtt
    22201 gcccatgtcg agcacgagca ggcccatgat ccggctgcgg cccgcgcgga gctggcgcgc
    22261 ggactcgctg cggacatagc cgagccggtc gatcgcggac aggacccgcg cgcgcgtctc
    22321 ggtggcgacc gtctccggcc ggttgatgac gttcgagacc gtgccgacgg agactccggc
    22381 ggcacgggcc acgtccttga tacccaccga ctgggccatc ggacagggac ctccagggtc
    22441 gggctagggg ggcgacgggt ggtggtgcgg ccggaggagc ttcacattac cgtcgttccg
    22501 tcccaccacg gccgggtggt gcctccccgt gcccgagggg cggggtgccg gtgggtcagg
    22561 cgaggtggaa gacctcggtg aggggcttca tcgcctcgtc ggggcgggct ccgtcgaggg
    22621 attcgaagaa gggggccatc tcggcctgcc a
//
