LOCUS       NZ_LN831790            10216 bp    DNA     linear   CON 08-APR-2024
DEFINITION  Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 =
            NRRL B-24963) chromosome 1.
ACCESSION   NZ_LN831790
VERSION     NZ_LN831790.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Gomez-Escribano,P.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2015) JIC, Department of Molecular Microbiology,
            Norwich Research Park, Norwich, NR4 7UH, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001013905.1-RS_2024_04_08
            Annotation Date                   :: 04/08/2024 03:45:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,096
            CDSs (total)                      :: 7,005
            Genes (coding)                    :: 6,806
            CDSs (with protein)               :: 6,806
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 82 of 199
            Pseudo Genes (incomplete)         :: 160 of 199
            Pseudo Genes (internal stop)      :: 10 of 199
            Pseudo Genes (multiple problems)  :: 49 of 199
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:33:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 572463
            Orig. end                         :: 582679
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN831790.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    367..382
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.49"
                     /tool="antismash"
     misc_feature    377..391
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    594..605
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            complement(744..923)
                     /locus_tag="BN2145_RS03885"
                     /old_locus_tag="ABM27_RS03800"
     CDS             complement(744..923)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389406.1"
                     /locus_tag="BN2145_RS03885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS03800"
                     /product="hypothetical protein"
                     /protein_id="WP_029384803.1"
                     /transl_table=11
                     /translation="MTTDTGDKPATRRPETGWSTARRLRGHVAPRTWIPAVEDGDPPRT
                     PQPGPDPHIVRGED"
     gene            complement(1226..1645)
                     /locus_tag="BN2145_RS03890"
                     /old_locus_tag="ABM27_RS03805"
     CDS             complement(1226..1645)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040498.1"
                     /locus_tag="BN2145_RS03890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS03805"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_029384804.1"
                     /transl_table=11
                     /translation="MVQYVRDIMTSEPVTVEPQASVVDVARIMRDEDLGAVLVTEGDRL
                     RGLVTDRDLVIRALAEGGDPQQTTVAGACSDDVVTVRPDEELDHVVELMREHAVRRIPV
                     VDEGHPVGIVSLGDMAMERDPESALGDISVARPNT"
     gene            complement(1763..2206)
                     /locus_tag="BN2145_RS03895"
                     /old_locus_tag="ABM27_RS03810"
     CDS             complement(1763..2206)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN2145_RS03895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ABM27_RS03810"
                     /product="hypothetical protein"
                     /protein_id="WP_029384805.1"
                     /transl_table=11
                     /translation="MPDVLCLVESAGVPGSLYGLREGYPVTGHSPVADAHRDGRPVRLG
                     PGDVAGRAESRRAPCGEFSLEALPVRRDGGGCLLSVTEDPGGFGPDARACLERIAEAVK
                     PTGIGWEATGGRGVLLVEAVSAAWGTLPAGGGKQVWCEIPLSR"
     gene            2312..4486
                     /locus_tag="BN2145_RS03900"
                     /old_locus_tag="ABM27_RS03815"
     CDS             2312..4486
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117170.1"
                     /locus_tag="BN2145_RS03900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS03815"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_029384806.1"
                     /transl_table=11
                     /translation="MVVVTDRQSTPGEPAGSGPVVGRSALSLALASMMEEVHAHAGAVY
                     LLSADRRVLEMAVIAGLPRSFAAPWERVPMTARIPVADAVRERRLIWVGGEEEMARRYP
                     RVAVVLPYPFALAALPVAAGSTVYGGVFLTWPGTRPADLSEREREQLAAACDRLALRLK
                     RGAGTRPPAPHQPEPAAAPAVGGVAGSLGALEAVRMAGRLPYGLCSLDAHGRVGFVNPA
                     AAELLGVPADRLLGTPLWAAVPWLNDPVYEDRYRAALLSQHTASFVALRPPGEWLSFRL
                     YPSRNGVSVRIGLARGMSGAGRAGAEAGAGPGRAPAETPSRLVTIAQVLSLAGALTEAA
                     GVQDVVQLVADEIAPTLGSQALVLLGSRAGRMHVLGHRGYPDPYVVERFDGMPLTEHTP
                     GTQVLRTGVPAFLESAEQLEHLYPVRRATPDGFAAWAYLPLIASGRPVGTWVLAYARPH
                     PFPAEERAVLTSLAGLVAQALDRALLFDAKHRLAHGLQEALLPHSLPSLPGIEAAARYL
                     PATRGMDIGGDFYDLMPVEGMAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTAVGQTPEE
                     VMRRTNRLLIDLGSDLFASCLYLRIDPARRRAVLARAGHPPPLLRRPDGRVRVLDLAGG
                     PLLGIDASAAYPASEVDLSPGSLLVLYTDGLVESPGVDFEDALADLGRRLGQAGDLPLD
                     ALADALVRHVAKAEERIDDIALLLLRTREG"
     misc_feature    4496..4509
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.0"
                     /tool="antismash"
     misc_feature    4676..4691
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(4753..4768)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            5001..5216
                     /locus_tag="BN2145_RS03905"
                     /old_locus_tag="ABM27_RS03820"
     CDS             5001..5216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="BN2145_RS03905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS03820"
                     /product="hypothetical protein"
                     /protein_id="WP_029384807.1"
                     /sec_met_domain="strepbact (E-value: 1.5e-32, bitscore:
                     110.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETVEIADTELDNVSGGLAINALNTVTGVVDSVAPVTGL
                     VNGVVDTVEGVTGLNTAPVTGLVAGL"
     gene            5337..6143
                     /locus_tag="BN2145_RS03910"
                     /old_locus_tag="ABM27_RS03825"
     CDS             5337..6143
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="BN2145_RS03910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS03825"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_029384808.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPDELDLPVRFARPQGWLVLSVTVVAMAAASVW
                     AVTGSVASTVSAPAVLTHGQGSYVLQSPVSGQVTAVLAEQGERLPAGAPVLKVRTAEGE
                     TVVRALDAGRVSALAATVGQIVQTGANVAAVEKVAHARDPLYATVYVPAENAAEIRAGA
                     AVDLTVQSVPSQEYGVLRGHVKSVDRSAQSAQQIGAFLGDSQLGEQFTKEGRPVAVTVR
                     LDTSSATKSGYEWSTAGGPPYALTSMTLATGSIRLADQRPVDWLLP"
     gene            6140..8362
                     /locus_tag="BN2145_RS03915"
                     /old_locus_tag="ABM27_RS03830"
     CDS             6140..8362
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="BN2145_RS03915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS03830"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_029384809.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.3e-38, bitscore:
                     128.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDLKTRGRRRAAPPKRTVPKARAKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARGYGLTAKGMQMDLAALAEVTA
                     PAILFWEFNHYVVYDGMGRRFGRRGVYINDPGKGRRFVPLEEFDGSFTGVVLVMEPGEG
                     FTRGGRRPGVLGAMPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDEFLIGHQT
                     SLLGVLFTSMAACVLLTVVLTWLQQANLLRGRLISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAVVVVLYAVLLYTYDPQLTFVGIGVALLNIV
                     AMRVVIRLRATRTAKLRADSARLTNTSYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATFNSALILWIGGMRAVEGHISVGLLVAFQALVARFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFQADPLYGRPDAGDSTRRLQGHVELENITFGYNP
                     LDKPLLSGFDLIVGPGQQVALVGGSGSGKSTVSRLISGLYTPWEGVIRIDGRRIEDIPR
                     GALAASVSFVDQEVFLFEGTVRDNVALWDPSIPDDAVVEALRDAALYDVVMRRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQVVMDNLRKRGCACV
                     VIAHRLSTVRDSDEIVVLQHGTVVERGRHEELVARGGAYAALVRER"
ORIGIN
        1 ttctccccgt cgaggaggcg ggtgacgaac aacgggatga tcttctcggg gaactggcgg
       61 ggaccgtagt tgttggagca gcgggtgatc cgcacgtcca ggccgtgggt ccggtggtgg
      121 gcgagggcga gcaggtcggc ggcggccttg gaggcggagt acggggagct gggccgcagc
      181 gggtccccct ccgtcgccga gccggactcc agggagccgt acacctcgtc ggtggagacg
      241 tgcacgaacg gttccacgcc gtgccgcagc gccgcgtcga ggagcgtctg ggtgcccacg
      301 acgttggtgg tgacgaagtc ggtggcggtg tggatggagc ggtccacatg ggattccgcg
      361 gcgaagtgca ccacctggtc ggcgtcggcc atcagcttgt cgaccagtgc ggcgtcgcgg
      421 atgtcgccct gcacgaagtc caggcggggg tggccgagtt cgaggttgtc cgggttcccg
      481 gcgtacgtca gcttgtccag caccgtgatc cgcggcgctc cgggcgcgtc ggaggcgagc
      541 agcgcgcgga cgtagtggga accgatgaat ccggcggcgc cggtgacgag gaggttcatg
      601 aacgcgtgtg caccttgctg tgtcctgctg ccggcatgcc ggcgacgtta ccagtgagcc
      661 gcgggtggcc tgcgcgtcct cccgtgaccg tcacccgtcc gccgggccgt ggcgcgcggc
      721 ggcacggtgc gcggtgcggg ccgtcagtcc tcgcccctga cgatgtgcgg gtcggggccc
      781 ggctggggcg tgcgcggcgg gtcgccgtcc tcgacggccg ggatccaggt gcgcggggcg
      841 acgtggccgc gcaggcggcg cgcggtcgac cagcctgtct ccggtcggcg ggtggcgggt
      901 ttgtcaccgg tgtccgtggt cacggggcat cgtcttcctt ccgggtgcgg gcgagggacg
      961 cccgtgcggt gccggcgtcg cggcgcggca cggggaaccg gcgccgggtt cccagggatc
     1021 gccggtgtca aacgtcagac cgccgcccgg ccgcgcctcg cccgcacgcg cgcggggccc
     1081 cgccggtggt tcgggccgcg acgtgcgacc ggcctcgcgg caccgtccgt tccggtgcgc
     1141 gcgaggccgg cgggccgcgt gcggccgggc ccgtgggccc ggggcggcgc ggccccgggg
     1201 gcgtggctct gccgccgtgt cgccgttacg tgttcggccg ggccacgctg atgtcgccga
     1261 gcgccgactc cgggtcacgc tccatggcca tgtcgccgag ggagacgatg cccaccggat
     1321 gtccctcgtc gacgaccggg atgcggcgca ccgcgtgctc gcgcatcagc tccaccacgt
     1381 ggtccagctc ctcgtcgggc cggacggtca ccacgtcgtc gctgcacgcg ccggccacgg
     1441 tggtctgctg cgggtcgccg ccctccgcga gcgcccggat caccaggtcc cggtcggtga
     1501 ccagcccgcg cagccggtcc ccctcggtca ccaggacggc tccgaggtcc tcgtcccgca
     1561 tgatgcgggc cacgtcgacg acggaggcct gcggctcgac ggtcaccggt tcactcgtca
     1621 tgatgtcgcg gacgtactgg accatgacgc acctctttcc tcgccttctc ggcgctgtgt
     1681 gctctgccgg tccgggtacc cgcggacgcg gttccggcac gccggggcgg gcgggaaccg
     1741 ggccggtggc ggccggcggc gttcaccggg acagcgggat ctcgcaccac acctgcttcc
     1801 ccccgccggc cgggagggtc ccccaggccg ccgacaccgc ctcgacgagc aggacaccgc
     1861 ggcccccggt ggcctcccag ccgatgccgg tgggtttgac ggcctcggcg atccgttcca
     1921 ggcacgcccg ggcgtcgggg ccgaagccgc ccgggtcctc ggtgacggag aggaggcatc
     1981 cgccgccgtc ccgccgcacg ggcagggcct ccaggctgaa ctccccgcac ggcgcgcgcc
     2041 gcgactcggc gcgtccggcg acgtccccgg ggccgagccg gaccggccgc ccgtcgcggt
     2101 gggcgtcggc cacgggcgag tggccggtga cgggatagcc ctcgcgcagc ccgtacagcg
     2161 acccgggcac accggccgac tccaccaggc acagcacgtc cggcacgccc gcgctgcggc
     2221 cggagccggg ggcttcgagc ggctcgccgt gcgccccggg ccgtcgcgag ggagatttgt
     2281 ccctgggacc gtcgcccggc cgtgcgagga ggtggtcgtg gtgaccgacc ggcagtcgac
     2341 ccccggggag cccgcgggct ccggaccggt ggtcggccgg tccgcgctct ccctggcgct
     2401 ggcctcgatg atggaggagg tccacgcgca cgccggtgcg gtgtatctgc tctccgcgga
     2461 ccggcgggtg ctggagatgg cggtgatagc ggggcttccc cggtcgttcg cggccccctg
     2521 ggaacgggtc ccgatgaccg cgcggatccc ggtggccgac gccgtgcgcg aacggcggct
     2581 gatctgggtc ggcggcgagg aggagatggc ccggcgctat ccgcgggtcg cggtggtcct
     2641 gccctacccg ttcgccctgg ccgcgctccc ggtggcggcc gggtccaccg tgtacggcgg
     2701 ggtgttcctg acctggccgg gcacgcgccc cgcggatctg tccgagcggg agcgggagca
     2761 gctggcggcc gcctgtgacc ggctggcgct ccggctgaag cgcggggcgg ggacgcgtcc
     2821 gcccgcgccg caccagccgg agccggccgc cgcgccggcc gtggggggag tcgccgggtc
     2881 gctcggtgcc ctggaggccg tgcggatggc gggccggctg ccgtacggac tgtgctcgct
     2941 ggacgcgcac gggcgcgtcg gcttcgtcaa tccggcggcg gccgaactgc tgggcgtacc
     3001 ggccgacaga ctgctcggca ccccgctgtg ggcggccgtg ccgtggctga acgacccggt
     3061 gtacgaggac cgttaccggg cggcgctgct cagccagcac acggcctcgt tcgtggcgct
     3121 gcgcccgccc ggcgagtggc tgtcgttccg gctgtacccg agccggaacg gggtgagcgt
     3181 ccgcatcggc ctggcccggg ggatgtccgg ggccggacgg gccggtgccg aggccggcgc
     3241 cgggcccggc cgggcaccgg ccgagacgcc gtcccgcctg gtgaccatcg cgcaggtgct
     3301 gagcctggcc ggggcgctga ccgaggcggc gggcgtgcag gacgtggtgc agctcgtcgc
     3361 ggacgagatc gccccgacgc tgggcagcca ggcgctggtg ctcctcggct cacgggcggg
     3421 ccggatgcac gtgctggggc accggggcta tccggatccc tacgtcgtgg agcggttcga
     3481 cgggatgccg ctgaccgagc acactcccgg cacccaggtc ctgcggacgg gggtgcccgc
     3541 cttcctggag tccgcggagc agctcgagca cctgtatccg gtccggcgag ccaccccgga
     3601 cggcttcgcg gcctgggcct atctgccgct gatcgcctcc ggccgcccgg tgggcacctg
     3661 ggtgctggcc tacgcccggc cgcatccgtt cccggcggag gagcgggcgg tgctgaccag
     3721 cctggccggg ctggtcgccc aggccctgga ccgcgccctg ctgttcgacg ccaagcaccg
     3781 cctggcccac gggctccagg aggccctgct gccgcactcg ctgccgtccc tgccgggcat
     3841 cgaggcggcc gcccgctatc tgccggccac ccggggcatg gacatcggcg gcgacttcta
     3901 cgatctgatg ccggtcgagg gcatggccgc cgcggtgatc ggggacgtgc agggccacaa
     3961 cgtgaccgcg gccgggctga tggggcagat ccgcaccgcc gtccgcgcgt acacggccgt
     4021 cggccagacg ccggaggagg tcatgcgccg gaccaaccgg ctcctgatcg acctgggcag
     4081 tgatctgttc gcgagctgtc tgtacctgcg gatcgacccg gcccgccgac gggccgtgct
     4141 ggcccgcgcg gggcaccccc cgcccctgct gcggcggccg gacgggcggg tgcgggtcct
     4201 cgatctggcc ggcggtccgc tgctgggcat cgacgcgtcg gcggcgtacc ccgcgtcgga
     4261 ggtcgacctc tcccccgggt ccctgctcgt cctctacacc gacggcctgg tggagtcgcc
     4321 cggcgtcgac ttcgaggacg ccctcgccga cctggggcgg cggctcgggc aggccgggga
     4381 cctgccgctg gacgcgctcg ccgacgccct ggtgcggcat gtcgcgaaag cggaggagcg
     4441 catcgacgac atcgccctgt tgctgctgag gacgcgggaa gggtgagaag gcggcgacac
     4501 ggctgtttcc tgcggatatg tcagtatcga tctactccga atcactgaca cacagcaatt
     4561 gatcggtgac gttctgtcga gaacaccgag cggaatcctc gcttcagcga atctgcacat
     4621 cggctgccca acccggtcac cgcccacggg ggatctgcac aagcgcccgg ccccgctcac
     4681 gcctttggga cccaagtgcc ggattcgccg accgagccgc gcggccctcg gcgccccggc
     4741 accgcgccgc atgtgaagaa gtcgccagca agccgtgcgc gcacctgcac caaaaggtgg
     4801 ccgggcggtt cgaaaggcct ggtgggaggc ggtggttgag tggaacggcg ggctggcgcc
     4861 gtgctttgat ccatcgcacc gcgggggccg cgaacggttc cccggaccgg gcgcccggca
     4921 cccgcggccg cggccgtcca tctgtcccca gagggggccg ctcccccctt gtgaatatcc
     4981 atatgaaggg aagttccatc atgaactcca ccccccaggt cgagaccgtc gagatcgccg
     5041 acaccgagct ggacaacgtc tccggtggtc tcgccatcaa cgccctgaac accgtcaccg
     5101 gcgtggtgga cagcgtcgcc ccggtcaccg gcctggtgaa cggcgtcgtc gacacggtcg
     5161 agggtgtcac gggcctgaac accgccccgg tcaccggcct ggtcgccggt ctctgatcgc
     5221 gcccacgcgc taccgaagtc ccggagccgc tccccggctc cgggactctc gggtgccgtc
     5281 acagccccgg cccgcccggg gcggttccgt caagttccgc aggtgaggga aggtccgtgc
     5341 agttccgcca gcaggccctc gccaagctgc agtcgccgga cgagctcgat ctgccggtgc
     5401 ggttcgcccg cccgcagggc tggctcgtcc tctccgtcac cgtcgtcgcg atggccgccg
     5461 cgtccgtgtg ggcggtgacc ggttcggtcg cctccaccgt cagcgcgccc gccgtcctca
     5521 cccacgggca gggcagctat gtgctgcaga gcccggtctc cggccaggtc accgccgtcc
     5581 tcgccgaaca gggcgagcgg ctgcccgccg gcgcgccggt gctgaaggtc cgtaccgccg
     5641 agggcgagac ggtcgtccgc gccctcgacg cgggccgggt cagcgcgctc gccgccaccg
     5701 tcggccagat cgtccagacc ggtgcgaacg tcgccgccgt cgagaaggtc gcccacgccc
     5761 gggaccccct gtacgccacc gtgtacgtcc ccgccgagaa cgccgccgag atccgggcgg
     5821 gcgccgccgt ggacctgacc gtgcagtcgg tgccctccca ggagtacggc gtcctgcgcg
     5881 gccatgtgaa gtcggtggac cgctcggccc agtccgcgca gcagatcggc gcgttcctcg
     5941 gcgacagcca gctcggcgag cagttcacca aggagggcag gccggtcgcg gtgacggtcc
     6001 gcctcgacac ctcctccgcc accaagagcg gttacgagtg gtcgacggcg gggggacctc
     6061 cgtacgccct cacctccatg actctggcca cgggctcgat ccggctggcc gaccagcgtc
     6121 ccgtcgattg gctgctgccg tgaccaccga cctgaagacc cggggcagac gccgtgccgc
     6181 cccgcccaag cgcacggtgc ccaaggcgcg ggcgaagacc gtccgcaccc cgaccgtgct
     6241 gcagatggag gccgtcgagt gcggcgccgc ctccctggcg atggtgctcg gccactacgg
     6301 ccgccatgtc ccgctggagg aactgcgcat cgcctgcggt gtctcccgcg acggctcgcg
     6361 cgccagcaac ctgctcaagg cggcccgcgg ttacggcctg accgccaagg gcatgcagat
     6421 ggacctggcc gccctcgccg aggtgaccgc gccggccatc ctgttctggg agttcaacca
     6481 ctacgtcgtc tacgacggca tgggccgccg cttcggccgc cgcggggtgt acatcaacga
     6541 ccccggcaag gggcgccggt tcgtgccgct ggaggagttc gacggcagct tcaccggcgt
     6601 cgtgctggtc atggagcccg gcgagggctt cacccgcggt gggcgcaggc cgggcgtgct
     6661 gggcgcgatg ccggcccggc tgcgcggcac ggcgggcacc ctgcccgccg cggtgctggc
     6721 gagcctgctg ctggtggccg tcggcgcggc ggtgcccgcg ctcagccgca cctacatcga
     6781 cgagttcctc atcggccacc agacctcgct gctgggtgtg ctgttcacct cgatggcggc
     6841 gtgcgtgctg ctcaccgtcg tcctgacctg gctccagcag gccaacctgc tgcgcggccg
     6901 gctcatctcc tccaccctgt ccagcgcccg cttcctgcgc catctgctac ggctgccggt
     6961 gaccttcttc tcccagcgca gcccggccga cctggtgcag cggctccagt ccaacgacgc
     7021 ggtggccgag accctggccc gcgacctggc ggcggcgggc gtggacgcgg tggtggtcgt
     7081 cctgtacgcg gtgctgctgt acacctacga cccccagctc accttcgtcg gcatcggcgt
     7141 ggccctgctg aacatcgtgg cgatgcgggt cgtcatccgg ctgcgcgcca cccgcaccgc
     7201 gaaattgcgg gcggacagcg cgcggctcac caacacctcg tacaccggtc tgcagttgat
     7261 cgagacgatg aaggcgaccg gcggcgagga cggctacttc cgcaagtggg ccgggcagca
     7321 cgccacgacc ctggaggaac agcagcggct cggcgtgccg agcgcctggc tgggcgtggt
     7381 ggcgccgacg ctcgccacct tcaacagcgc gctgatcctg tggatcggcg gcatgcgcgc
     7441 ggtggagggc cacatctcgg tcgggctgct ggtcgccttc caggcgctgg tggcccgctt
     7501 caccgccccg ctgacccgtc tgaacggcgt cgcgggtcgc atccaggact tcgcggccga
     7561 cgtggcccgc ctgaaggacg tggagaactt ccaggccgac ccgctctacg gccgccccga
     7621 cgccggcgac tccacgcgcc gcctgcaggg ccatgtcgag ctggagaaca tcaccttcgg
     7681 ctacaacccc ctcgacaagc ccctgctcag cggcttcgac ctgatcgtcg ggccggggca
     7741 gcaggtggcg ctggtcggcg gctcgggcag cggcaagtcc accgtgtccc ggctgatctc
     7801 gggcctgtac acgccgtggg aaggcgtgat ccgcatcgac ggccggcgga tcgaggacat
     7861 cccgcgcggg gcgctggcgg cctccgtctc cttcgtcgac caggaggtgt tcctcttcga
     7921 gggcacggtc cgcgacaacg tggcgctgtg ggacccgtcc atccccgacg acgcggtggt
     7981 ggaggcgctg cgggacgcgg ccctgtacga cgtggtcatg cgccgccccg gcggcatcca
     8041 cagccgggtc gagcaggacg gccgcaactt ctccggcggg cagcgccagc gcctggagat
     8101 cgcgcgggcg ctggtgcgcc ggcccagcat cctcgtcctg gacgaggtga cgagcgcact
     8161 ggacgccgag accgaacagg tggtcatgga caacctgcgc aagcggggct gcgcctgcgt
     8221 ggtgatcgcg caccggctca gcaccgtgcg cgacagcgac gagatcgtcg tgctccagca
     8281 cggcacggtc gtggagcgcg ggcggcacga ggagctggtg gcgcgcggcg gcgcgtacgc
     8341 ggcactggtc agggagcggt gagatgacgt ccgtccacga ggaggacctg gtcctcggcg
     8401 cgctcgtccg gctgggcacc cggctggact gcgccggctt cggccggctg gacctggagg
     8461 gtccgcaggt gctgtggctg gtcgcggcgg gcgccgtcga cctgttcgcg gtggacgccg
     8521 cgcagcaggg ccactggcac cacctcggcc ggctggaggc gggttcgctg ctgctcggcc
     8581 cggtcgccgg accgcagcac acactggtgg cccgtccgct gcgcgactgc gtggtgcacc
     8641 gcatcggcct gcgtgagctg taccagccgg cgaccacgca gacctggtcg tacgacgagt
     8701 acggcaatcc gcagtacgtc ccgccggcga cgagcccgct ggagcacgcc ctcgccctcg
     8761 gcgtgggccg cagcctgtcc atcctgttcc aggcgccgat ggccaccgag cgggccgcgg
     8821 cgcccgccgc cgacgacgac gtgttctgga tgcaggtacc gccgggcagc gtgcagtacg
     8881 gcgagctgta cggcgccgag gccgcggccg acctgctgat ggacccggcg ctgtggcaga
     8941 gcatggtcga ccagcagtac cgcctgctga ccacgctgga ccgctggatc gagcagctcg
     9001 agcgcaccca cgagacccgg accgcggagg gcatcaaggc cggtgaggcg gtgcgcgccc
     9061 gggccgaccg gacgctgctg gcggcgatcg gcaagccgtc ggggcagcgg accacggccg
     9121 ccgacgcgga cgcgacgtac gcggcgtgca ggctggtcgc ccgggccgcg ggcatcgcgc
     9181 tggccgagcc cgcgcacagc ggtgcggaga gcgaccggct cgatccggtg gagcgggtcg
     9241 ccgtcgcctc ccgggtgcgc acccgggccg tccgtctcca gggccgctgg tggcgggaga
     9301 acgtcgggcc gctggtgggc cggcgggcgc tgtccggggc gccggtggcg ctgctctggc
     9361 ggcgcggcgg ctatgtggcg gtgcatcccg gctccgggcg ggagacggcc gtggacaagg
     9421 ccaacgccga ggagttcgag ccgcgcgcgg tgatgttcta ccggccgctg cccgaacgcc
     9481 ggctcagccc gctgcggctg atgcggttct gtctgcgggg cacccgcggc gacctgctca
     9541 acctgctggc cagcgggctg gtgacggtgg cgatcggggc gctggtgccc ctggcgacgg
     9601 gcaaggtgct cggcgagttc gtgccgcgcg cccagaccga actgatcgcc caggtctgcc
     9661 tgacggtgat gatcggcggt gtcgtcgcgg cggcgttcat gctgctgcag aacctcacca
     9721 tcctgcggct ggagggccgg atcgaggcca ccctccagcc ggcggtgtgg gaccggctgc
     9781 tgcggctgcc gacgaccttc ttcaccgagc gttccaccgg cgagctggcg agcgccgcca
     9841 tgggcatcag cgcgatccgt cggctgctgg cgggggtcgg cccgacggtc gtccagtcgg
     9901 tgaccgtcgg cgcggtgaac ctggcgctgc tgctgtggtt cagcgtgccg atggcgctgg
     9961 cggcgatcgg catgctcgtc gtgatcgccg cggtgttcct ggcgctcggg ctgtggcagg
    10021 tgcgctggca gcggcggctg gtggtgctca ccaacaagct gaacaaccag gccttccaga
    10081 cgctgcgggg cctgcccaag ctgcgggtcg ccgcggccga gaactacgcg tacgccgcct
    10141 gggcggagcg tttcgcgcac agccgtgagc tccagcagaa ggcgggccgc gtcaagaacc
    10201 tcaacgccgt gctggg
//
