LOCUS       NZ_LN831789            22469 bp    DNA     linear   CON 08-APR-2024
DEFINITION  Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 =
            NRRL B-24963) plasmid pSLE2.
ACCESSION   NZ_LN831789
VERSION     NZ_LN831789.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Gomez-Escribano Juan,Pablo.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2015) JIC, Department of Molecular Microbiology,
            Norwich Research Park, Norwich, NR4 7UH, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001013905.1-RS_2024_04_08
            Annotation Date                   :: 04/08/2024 03:45:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,096
            CDSs (total)                      :: 7,005
            Genes (coding)                    :: 6,806
            CDSs (with protein)               :: 6,806
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 82 of 199
            Pseudo Genes (incomplete)         :: 160 of 199
            Pseudo Genes (internal stop)      :: 10 of 199
            Pseudo Genes (multiple problems)  :: 49 of 199
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:33:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 93530
            Orig. end                         :: 115999
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LN831789.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22469
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22469
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22469
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12469](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12469
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(108..395)
                     /locus_tag="BN2145_RS01145"
                     /old_locus_tag="ABM27_RS01145"
     CDS             complement(108..395)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016826394.1"
                     /locus_tag="BN2145_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01145"
                     /product="hypothetical protein"
                     /protein_id="WP_029380894.1"
                     /transl_table=11
                     /translation="MNRRGIAAAVIGATALFGLTVPAATAAPQALDCTTSVGDTGGWAE
                     CTGSGTWRVRSVCSFADYDRYTQWVTTTKRTRVYASDCTFKIVDVVVQVK"
     misc_feature    complement(460..475)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.72"
                     /tool="antismash"
     gene            806..1093
                     /locus_tag="BN2145_RS01150"
                     /old_locus_tag="ABM27_RS01150"
     CDS             806..1093
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016826394.1"
                     /locus_tag="BN2145_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01150"
                     /product="hypothetical protein"
                     /protein_id="WP_029380893.1"
                     /transl_table=11
                     /translation="MNRRGIAASVIGATALFGLAVPAATAAPQALSCTTSVGNTGGWAE
                     CTGSGTWRVVSICNNERDKYTTWATQSGGTTRRYAVDCSWDIDRVQVEMK"
     gene            complement(1124..1519)
                     /locus_tag="BN2145_RS01155"
                     /old_locus_tag="ABM27_RS01155"
     CDS             complement(1124..1519)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN2145_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ABM27_RS01155"
                     /product="hypothetical protein"
                     /protein_id="WP_157840605.1"
                     /transl_table=11
                     /translation="MTDERANRKMHRVRAKRQRDGWVLQIAGTDEIWIRRLTEAGAAAR
                     SRISEGTDIPLGEIDIQIDIHLDEPLQSRKKEAVQAVLDARRAQERAARAYRDVARSLQ
                     ESGATGAEIALILDVSRQRVSQLLAEK"
     misc_feature    1633..1649
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.75"
                     /tool="antismash"
     gene            <1634..>1867
                     /locus_tag="BN2145_RS37435"
                     /pseudo=""
     CDS             1634..>1867
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611180.1"
                     /locus_tag="BN2145_RS37435"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVKLGIGSAETVRTWNRMPAVDAGQCPGVASEEAAEIKRLKAEER
                     RAEAGQRDPQGGLGFRGRARPAVEALVAFIDEH"
     gene            complement(<1913..>2056)
                     /locus_tag="BN2145_RS37440"
                     /pseudo=""
     CDS             complement(<1913..2056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612078.1"
                     /locus_tag="BN2145_RS37440"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRSVRDAELKMQISRVNADNFSVYGVRKVSRQLHREGRPVARCAV
                     ARM"
     misc_feature    2017..2031
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     gene            2070..2330
                     /locus_tag="BN2145_RS38475"
     CDS             2070..2330
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN2145_RS38475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158810632.1"
                     /transl_table=11
                     /translation="MRTLHASTAAAVFAPPSATTATSGRMTELPTAEWVDWFRRDRWVF
                     GNRNSGAFLPKFAWTGIVRHKLVKGGASMDDPALILQPQLL"
     gene            2848..>3474
                     /locus_tag="BN2145_RS01175"
                     /old_locus_tag="ABM27_RS01165"
                     /pseudo=""
     CDS             2848..>3474
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005176048.1"
                     /locus_tag="BN2145_RS01175"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01165"
                     /product="reverse transcriptase domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNTDALEFALLKAERRVLEMQTKLHCWATDDRDRGFDDLFNLVAD
                     PAFLLVAWDRVRRNRGARSAGVDGQTARSVEDGQGVEAFLDEVRSDLRDRTFRPLPVRE
                     RMIPEPGTAKRRRLGIPTVRDRVVQASLKLVLEPIFEADFLPCSYGFRPKRRAHDALAE
                     AHHFAKNSYEWMVEGDIEACFDSIDHTALMGRMRRRVGDRRVLDLV"
     gene            3512..>3892
                     /locus_tag="BN2145_RS01180"
                     /old_locus_tag="ABM27_RS01170"
                     /pseudo=""
     CDS             3512..>3892
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026834.1"
                     /locus_tag="BN2145_RS01180"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01170"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPCPGQELSVPLVVGTSPWIVSDELWDRLEPLLPQRERRFRYPGR
                     KPLPDREVLCGILYVLHTGIQWEYLPRELGFGSGMTCWRRLRDWNEAGVWQRLHEVLLA
                     ELNAASRLDWSRCVIDSSHVRAL"
     gene            complement(3915..>4304)
                     /locus_tag="BN2145_RS01185"
                     /old_locus_tag="ABM27_RS01175"
                     /pseudo=""
     CDS             complement(3915..>4304)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011600011.1"
                     /locus_tag="BN2145_RS01185"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01175"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LSPVLISMPGIGIRTAARILIDVGDGSGFATAGHLAAYAGLAPVT
                     RSSGSSIRGEHPPRRGNKQLKRAFYLAAFASLSQPESRAYYDRKRREGKHHVAALVALA
                     RRRIDVLFAMLRDGTFYQSPTPATA"
     gene            complement(4328..5566)
                     /locus_tag="BN2145_RS01190"
                     /old_locus_tag="ABM27_RS01180"
                     /pseudo=""
     CDS             complement(4328..5566)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018733410.1"
                     /locus_tag="BN2145_RS01190"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01180"
                     /product="IS110 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTVTCGIDWASDHHDVALVDHEGTLLARARITDDLAGLHQLLELL
                     TTHGDTANAPAPIAIETSRGLLVACLRATGRPVYAINPMAAARYRDRHTVTRKKSDHLD
                     AMVLANILRTDKAAHRPLPDDSELAQAIAVLARAQQDAVWDRTQAGNKLRSHLREYFPG
                     YLAAFQHNREGISSSVARAVLAAAPTPSRQPSSPAPSCARC"
     misc_feature    complement(5489..5491)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<5997..6809)
                     /locus_tag="BN2145_RS01195"
                     /old_locus_tag="ABM27_RS01185"
                     /pseudo=""
     CDS             complement(<5997..6809)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014668711.1"
                     /locus_tag="BN2145_RS01195"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01185"
                     /product="IS110 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTDESGIGVYLGLDVGKGEHHAAAVNRAGKKVFDKPLPNSEPRLR
                     ELFDKLRARHGTVLMVVDQPASIGALPLAVARDAGCQVAYLPGLTMRRIADLYPGEAKT
                     DARDAFVIADAARAMPHTLRAVDPADETVAELAMIAGFDDDLAGESTRIANRLRGLLTQ
                     IHPSLERVLGPRIQHPAVLRLLERFGSPAQIRKAGRRRLVTLIRPKAPRMAERLVEDIF
                     TALDEQSVVVPGTDAAALIVPSLASSLTSVLDQRKLLAARIEELLEAHP"
     gene            <7039..7515
                     /locus_tag="BN2145_RS01200"
                     /old_locus_tag="ABM27_RS01190"
                     /pseudo=""
     CDS             <7039..7515
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012947988.1"
                     /locus_tag="BN2145_RS01200"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01190"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KKVTGQHTGPSPVDRGRAGSKHHLITDGHGTPLAVLLTGGNRNDV
                     TQLLPLLDAIPPVRGRVGRPRRKPDALFADRGYDHDIYRDRVRDRGILPAIARRGTRHG
                     TGLGTYRWVIERSFAWLHGFRRLRIRWERRADIHEAFLKLACCLITHRQLGSLC"
     gene            complement(<7531..7806)
                     /locus_tag="BN2145_RS01205"
                     /old_locus_tag="ABM27_RS01195"
                     /pseudo=""
     CDS             complement(<7531..7806)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026846.1"
                     /locus_tag="BN2145_RS01205"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01195"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRHRPYPSDLSDARWELIGPTLTAWRASRRGKGLDIGRPPEHDL
                     RSIMNAILYVDRTGIPWRYLPHDFAPWETVYGYFAAWQKEGVFDQLN"
     gene            7995..8795
                     /locus_tag="BN2145_RS01210"
                     /old_locus_tag="ABM27_RS01200"
     CDS             7995..8795
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026846.1"
                     /locus_tag="BN2145_RS01210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01200"
                     /product="IS5 family transposase"
                     /protein_id="WP_099053554.1"
                     /transl_table=11
                     /translation="MNHSGIKRSFTAWRASRRGKGLDIGRPPEHDLRSIMNAILYVDRT
                     GIPWRYLPHDFAPWETVYGYFAAWQKEGVFDQLNGLLRRLVRETEGRHGEPSACVLDAQ
                     SVKTSSNVPAAGQGIDAGKKIAGRKRHIGVDTLGLLLAVWVTAASVSDNAGGMHLMSHI
                     AATHPRVTKAWADTGYRTKAIEHGARLGIDVEVVQREPGTKGFKVIPRRWVVERTFGWF
                     MHHRRLARDYETHPHRSEAMIHIAMIDLISRRLTRESTPNWRDT"
     gene            9164..9628
                     /locus_tag="BN2145_RS01215"
     CDS             9164..9628
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016910674.1"
                     /locus_tag="BN2145_RS01215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GtrA family protein"
                     /protein_id="WP_078648026.1"
                     /transl_table=11
                     /translation="MTLTDKAGPQTRSRQLRAEVGRFGVIGGLGWLVDTLTFNFFLNIL
                     GLASVRSGLLASTIAIAFNYLGHRYWTYRSSATVSRSREVGLFALFSVIGMAIQNGVLA
                     ISHYGFGYTSAWADNIAKNMVGLGAATVFRFWAYRNLVFHVTHQSPADAR"
     misc_feature    9209..9211
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9359..9361
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9584..9586
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9813..9830
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.17"
                     /tool="antismash"
     misc_feature    complement(9820..9836)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            9859..9993
                     /locus_tag="BN2145_RS35945"
     CDS             9859..9993
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_103143102.1"
                     /locus_tag="BN2145_RS35945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaxapeptin family lasso peptide"
                     /protein_id="WP_103143102.1"
                     /transl_table=11
                     /translation="MEPQMTELQPEAYEAPSLIEVGEFSEDTLGFGSKPLDSFGLNFF"
     CDS_motif       9859..9945
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MEPQMTELQPEAYEAPSLIEVGEFSEDTL"
                     /locus_tag="BN2145_RS35945_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9946..9993
                     /prepeptide="core"
                     /locus_tag="BN2145_RS35945_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="7.90"
                     /molecular_weight="1614.8"
                     /monoisotopic_mass="1613.8"
                     /core_sequence="GFGSKPLDSFGLNFF"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MEPQMTELQPEAYEAPSLIEVGEFSEDTL"
                     /leader_location="[9858:9945](+)"
     gene            10001..11815
                     /locus_tag="BN2145_RS01220"
                     /old_locus_tag="ABM27_RS01205"
     CDS             10001..11815
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_047121368.1"
                     /locus_tag="BN2145_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01205"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_047121368.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.7e-38, bitscore:
                     125.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTGFLILPDSVGTDALRDRLPLLALRTLRYPSGRPWIVGRWDAE
                     EIMSARVGPVHVVVIGFCPVTTTELTSLISRIHTVSDVNRLVASLPGSFHLVAAVGRQL
                     RVQGSITGLRRIAWAKSDGHTFVSDRTDILADLTNAKIDDSLLATRVACGGMVPPPLRE
                     RSMWLGVNSLPPDRYLLVEGGQRTREVKWWQPPAPETTLAEGACRVREALVSALYSRNP
                     VHGRLSADLSGGLDSTSLAFLAARTTPHLLTHRWAEAEAGNDDGKYAAIAARELPNAEH
                     LVIPQSDIPPVFSDPHLNGDPEQPYLFARTAARAVYTARMLVAHSSTRHIAGHGGDELF
                     YKFPGYLHPLLRRRPLTAIRHIRAHLALSRWDRKATVAQLLDTSGFPDWWKRQADQLTA
                     PPPGGRFPPLGWGFMPLHAQPWVTGEALHAARATLREAAEEAHPLAPDRGQHQYLLALR
                     TTAPAYAQLGRLFERAGVRLDLPYLDDRVVEAALSVRLEERAHPWRYKPLLAEAMRGVV
                     PESIATRVTKGEFSADLSLGLRRNRASVLDFLADSAIAKRGLIDVDTLRRLLLAPQADH
                     SRNIALEHLVGCETWLRTTPKRQDAPAP"
     misc_feature    10076..10078
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    10310..10312
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11612..11614
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        11799..12047
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BN2145_RS01225_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="1.10E-26"
                     /identifier="RREFam002.1"
                     /label="BN2145_RS01225"
                     /locus_tag="BN2145_RS01225"
                     /protein_end="83"
                     /protein_start="0"
                     /score="83.7"
                     /tool="antismash"
                     /translation="MRLHPDIVIAETEDGAVLLHQRTGRYWQLNTTGMAVIESLTSGET
                     LAEITHRMAKRYGLPAEQVRQDVEAVVHQLHAAQIVES"
     gene            11799..12056
                     /locus_tag="BN2145_RS01225"
                     /old_locus_tag="ABM27_RS01210"
     CDS             11799..12056
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="BN2145_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01210"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_029381414.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.9e-26,
                     bitscore: 83.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-16, bitscore: 54.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLHPDIVIAETEDGAVLLHQRTGRYWQLNTTGMAVIESLTSGET
                     LAEITHRMAKRYGLPAEQVRQDVEAVVHQLHAAQIVESTS"
     gene            12053..12469
                     /locus_tag="BN2145_RS01230"
     CDS             12053..12469
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640867.1"
                     /locus_tag="BN2145_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_078648027.1"
                     /sec_met_domain="PF13471 (E-value: 6.7e-29, bitscore: 93.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPAALVKRRKLPFHRRVLPLVAVGVARLLSRTKPARLRAILSY
                     ARRGAAPATVEQAMAARQAVVAVSQRCAGQACLQRSIATALLCRARGSWPTWCTGVRTS
                     PFEAHAWIEAEGRLIGEPYPDGHYRPLLTVPPVS"
     gene            complement(12677..13060)
                     /locus_tag="BN2145_RS01235"
                     /old_locus_tag="ABM27_RS01215"
     CDS             complement(12677..13060)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677285.1"
                     /locus_tag="BN2145_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01215"
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_047121369.1"
                     /transl_table=11
                     /translation="MRAAAVAALALTPLTAPASASSEPHAAQAAIDCPSGYVCIYPEIN
                     FGGQPWVRRAVDGSVKDLPSAIRDRGSSIRNNSDRTARIYEKRNHAGRWVCVTRSGGSI
                     HDLRGYNLNDQTRSLKINRNDCG"
     misc_feature    13070..13087
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            13314..13571
                     /locus_tag="BN2145_RS01240"
                     /old_locus_tag="ABM27_RS01220"
     CDS             13314..13571
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115022.1"
                     /locus_tag="BN2145_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01220"
                     /product="hypothetical protein"
                     /protein_id="WP_029381416.1"
                     /transl_table=11
                     /translation="MSDANVRIPEEARDRLAAIAAAEGMSLRAYLARLAETLLTPEERA
                     VRAEQARAALKEWNGYAPTPAEEQDLDSELDRRLSRAGAR"
     gene            13568..13948
                     /locus_tag="BN2145_RS01245"
                     /old_locus_tag="ABM27_RS01225"
     CDS             13568..13948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020665611.1"
                     /locus_tag="BN2145_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01225"
                     /product="hypothetical protein"
                     /protein_id="WP_029381417.1"
                     /transl_table=11
                     /translation="MSDAVHIVLDDTAMAAAGQGNVLASRLIHRAHAQAGWYLYAPACA
                     LVEADRARPGTAEHLAALPGITVLELDLPAALAVARHDTWAAAHCQYAAQPTPDRPDGA
                     VIATTVPDRWIGEPVRVLDLTP"
     gene            complement(13962..16634)
                     /locus_tag="BN2145_RS01250"
                     /old_locus_tag="ABM27_RS01230"
     CDS             complement(13962..16634)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039366.1"
                     /locus_tag="BN2145_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01230"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_029381418.1"
                     /transl_table=11
                     /translation="MAGRDLRALFSTNDRSLEAGEAFTNRQIQWEIVAAALTAHLRRTA
                     EAGFDVEDMEAPRDNVLVFHGVGGIGKTTLSRKLEAALAGAEHRPAQWGEPTWAGERIL
                     PVRIDLARSAGTDFEQLVLTIRAALSALGRPLPAFDLALRRYWETQHPGEPLEEYLRRG
                     GLAGRFGKAMPQQMQSAMADIAQTLLLPGTIGSAVGQVTGSLVRALRERRQTVRALAGC
                     ARLADLLETEPDLEALSFYPHLLAWELVQLPADKRVTPVILLDTFEDVGDRTHRDLERL
                     IQRVVWLMPNCFFIVTGRSRLQWADPALQGQLDYTGPAAWPGLAVPASTVPAARAGAVR
                     GRGRQVLVGDFSPEDCDDYLARRLSRDGQPLISSEIRQVITGRSHGLPLYLDLSVLRFL
                     EIRRTRQPVPSDFDHDFGALIARTLSDLTPDERHVLRSVSLLDAFDLTLATAAAGLAHQ
                     APAQRLIERPFVRENVFGLWPYHLHGLIRSTLRSADDATDDRWTDGDWQQAAERALAAL
                     GTQWTAAGGRNRMLLVGCLRQGLTLARDYRLELGWLADAAWAYVSDSVWEPIAPPARPG
                     RTGGLETSADALVELLTALARRQREHRSVTASRLAAVTGSGLLPADLHEMGVYYLAKAH
                     RDLGDSAASRHGMQLVADRGGRLAPAARRGLAHLARLAGDFPTAHATAQALGWAGRQHR
                     VEGDILWPHGDMDRAAAAYAAARNQAEQHGVAGERATSQAQRAFAVAFTDPDTADDELH
                     LAEQLLTGLDLRATNLTVRIAALVRDAGTPRGLEAARDLRAESHDAGITAAEAALELAL
                     AFHHAVLGEQDKVRAVTGRLRDLARTGDYAYYADIAHYMGGLPLPGPSAAHWLDGPEAV
                     RARWQRLVHTRRARLRAGG"
     misc_feature    16826..16839
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     gene            16832..17107
                     /locus_tag="BN2145_RS01255"
                     /old_locus_tag="ABM27_RS01235"
     CDS             16832..17107
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039365.1"
                     /locus_tag="BN2145_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01235"
                     /product="hypothetical protein"
                     /protein_id="WP_029381419.1"
                     /transl_table=11
                     /translation="MSDTPSSDFSGLEGGEEQAAEEAIQEVANWYNIQLLTERRAPLPD
                     EERIEELKAGREAALADGAQLATADREEAGRIAAVYAARLKELKEQ"
     gene            complement(17071..18921)
                     /locus_tag="BN2145_RS01260"
                     /old_locus_tag="ABM27_RS01240"
     CDS             complement(17071..18921)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109677.1"
                     /locus_tag="BN2145_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01240"
                     /product="zeta toxin family protein"
                     /protein_id="WP_047121370.1"
                     /transl_table=11
                     /translation="MRLEAPVEDLDACAVLSARESQDVLGSVILPAATASAVPQGRPVV
                     VVVGGQPGAGKTKVADLIQAALGQRGGAVRVGRDLYKAAHRHYAAALAADVRTAGAKVR
                     PDTSRWQTAVEKYVRDHGLDAVVESALADPDEFRESSAAYRRSRHRIEVVALATPEAWS
                     QLGILDRFLAEAASGAGGRYVSWANHDSCAKNMLTTLAVIEAEQLADRITVVTRDSTVL
                     YDNELVEGGWRRRPAAGTAVARGRSRPWTARETAAFHQELARAEVRVHRDVPGEDERLA
                     VIRDARRAAALAEPVRRIAQPRRRAPGVDYHRLSTAEHRWIFDELIVPSYLSGIITRDD
                     PRAVYVMGQPGAGKLLAARMVRRAMRPGTTRLVGDDLKAQHPDYFHLLRDDPRGAGAAI
                     RSDYRAWFAWAEQYVRDRRGDVLVEAAPGSVEEFLASALPFAAAGYSVELVVLAVRAAD
                     SRLATALRYARALQRGGTGRFTSRFGHDTCFSALADIVAVAEQHPQITAITVIRRDGQA
                     LLRHEAGSAGRASWALAAERLRPYTEQEAAAFLRLHHGLCRALPRHREELDEIAALARP
                     LMPARVQPARLGRPHPPVWPLPVPSRTAGYCSLSSFSRAA"
     gene            19027..21246
                     /locus_tag="BN2145_RS01265"
                     /old_locus_tag="ABM27_RS01245"
     CDS             19027..21246
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958342.1"
                     /locus_tag="BN2145_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01245"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_047121371.1"
                     /transl_table=11
                     /translation="MEVSSVPTENELFSAVDALLEEVAQDDLPPPEERKRLREAAGLSQ
                     EQIAKALKSRRETIGNWEAGVTEPRPPKRAAYARLLEGLAARFPAPATDAPATAPAPAI
                     PEAFTGPAPAPALEPVPAPASAPPSPPATSSTRPSASSRRPGAKKATKRPATTAAADGR
                     FENGPLAVVDVDDHGKVVAYCVGGLVLDVPVKSVPALVDWTLREAKLGQPKLSGPGKDA
                     DPLLVLTEAALERYGLPTTLTEEERLAGRLPEGHKVIKQLARAEWKLTKRGFGPWARIY
                     RPAQGSERACVQLCIPSWHALDTRHWGPAGRLPPADLARVLGVYASRVMTPRGSTAVTG
                     LELMTALHPPTRASEPDADGKRHSEHNPGSLGKDAIDPMNWPPCEVPDGHPVLQNLPRF
                     HVRGPGEKLFEEAYDWARPMTDAECTLRHLVGIDVNMAFAAGANGLTVGLGAPTHITNP
                     VFDPKLPGSWLVDLSHVDLSKVKVGKEWVELDGSLLPSPFTPKGERPTGPAWYATPTVA
                     YAAELGYEVRPIEAWVRYDNGRYLDSWYQRLRDAYLATMADLGVDADLAPADFLAAMDG
                     YKSRDPELAIVVSAIKATVKGGLGKLRERPRGEGWRPGEPWRALSRPTWRPDIRAAVIS
                     RTRINLHRKIVKHAAFTGQYPVAILSDCVVYASNGPSPLDFLPYRDGKPLPGGFKLGIN
                     PGLVKHEGTQTVLWGEEVRERFNAPELNLARYIKDGTVTDIDNGE"
     misc_feature    19063..19077
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            21259..21816
                     /locus_tag="BN2145_RS01270"
                     /old_locus_tag="ABM27_RS01250"
     CDS             21259..21816
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828477.1"
                     /locus_tag="BN2145_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABM27_RS01250"
                     /product="hypothetical protein"
                     /protein_id="WP_047121372.1"
                     /transl_table=11
                     /translation="MSLFGDGLEAAVQKAFTRPAPKSAGAQMRYLVKQLKGTKAVAQML
                     RVSQRTVERYVKNQIKKPRPDLAARLEREVKKRWQPQIRAKARQKAATTGGIVIDTRAR
                     LGYTAPIGSTDQDRIRHLTVALPPVYAARLFDAQEAGATDQELQEIAAEALKEIYFQDG
                     GRRAGSLEEVRFTDIEHLEFDL"
     gene            complement(21937..>22303)
                     /locus_tag="BN2145_RS01275"
                     /old_locus_tag="ABM27_RS01255"
                     /pseudo=""
     CDS             complement(21937..>22303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474044.1"
                     /locus_tag="BN2145_RS01275"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="ABM27_RS01255"
                     /product="DUF6233 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VEPAEYRVWVRAPDHVRPVDGVSYDQVPTEYLPKPSVVDQVLGPR
                     RPSGWVIAKAGGRGPGRGGVVHAVDCDEAPAGAPVLPLERAPGRGAAAGHPAVLAVWRG
                     RGTGLRPQGLRARLRRTV"
ORIGIN
        1 ctgccatagg tttatttatc ggcgcggcga ttcgagcgtt catcttcggc attacggccg
       61 gaagcagctg ctaatgacat ctgcccgacg cattcactcg cgaccgttta cttcacctgt
      121 accacgacgt cgacgatctt aaaggtgcaa tccgatgcgt acacccgcgt cctcttggtc
      181 gtggtcaccc actgggtgta ccggtcgtag tcggcgaagc tgcacacgga gcggaccctc
      241 cacgtgccgg agccggtgca ttcggcccac ccgccggtgt cgccgacgct ggtcgtacag
      301 tccagtgcct gcggcgcggc cgtggcggcc ggcacggtca gcccgaaaag agccgtcgcg
      361 ccgataacgg ctgcagcgat acctcgtctg ttcattttta tcctcccctg tgtgtaccgc
      421 agagcgcggc acgcacgcag cttgcatcac cacaacgcag atgatcaacc gcatttgaaa
      481 cgttggcgca aaagccaacg cctcaggcag gagctcaggc cgatcaagcg caatttgcga
      541 gaagagtaac ttttgttcat tttgcgcgac ccctaattgt accttttggg ctctaagtgc
      601 agtttcgcct tcccgggtcc actggatgct cggccaaata ttcggccgat tcagattgtt
      661 ccagcgacgg taaagtcccg atttatctgc tagctcggaa gcgtcgttcc cagccattgt
      721 cttgctagtc cgttgatcat cgaatggtct tcgtgcaggc tgcatgcgtg ccgcgcttcg
      781 cggtgcatac aggggaggat gaaaaatgaa cagacgaggt atcgctgcat ccgttatcgg
      841 cgcgacggct cttttcgggc tggccgtgcc ggccgccacg gccgcgccgc aggcactgtc
      901 ctgcacgacc agcgtcggca acaccggcgg gtgggccgaa tgcaccggct ccggcacatg
      961 gcgcgtggtc tccatctgca ataacgagcg tgacaagtac acgacttggg ccacccagag
     1021 cggtggcacc acacgtcgat acgcggtgga ctgctcctgg gacatcgacc gggttcaggt
     1081 ggagatgaag taagggcaca ccggcccggg cctccagtga atcctatttt tcggctagca
     1141 gttgtgaaac acgctgccga gaaacgtcga ggatcaaggc aatctcagcc ccggtcgctc
     1201 cggactcctg gaggctcctg gccacgtccc gataggctcg ggccgctctc tcctgagcgc
     1261 ggcgtgcgtc aagaaccgcc tgcacagctt cctttttcct gctttgcaga ggctcatcca
     1321 ggtggatatc gatctggatg tcaatctcgc ccaacgggat gtcggtgccc tcggagatcc
     1381 ggctccgggc agccgcacct gcctctgtga gccggcgaat ccatatctca tcggtaccgg
     1441 caatttgcag tacccatccg tctcgctggc gttttgcccg gacgcggtgc atctttctgt
     1501 tcgcgcgctc atctgtcatg aaggagagtc aaccccacct agatgcatct gtcaaggggc
     1561 cctagatgaa gaggctttcg ctgccacgcg atgtactcgc acgacacgcg tccatcgaag
     1621 acgggggaac gatgccgtga agctgggcat cggttccgcc gagacggtgc ggacgtggaa
     1681 ccgcatgccc gcggtcgacg ccggccagtg tcccggggtg gcgtccgagg aggccgcgga
     1741 gatcaagcgg ctgaaggccg aggaacgccg agctgaggcg ggccaacgag atcctcaagg
     1801 cggcctcggt ttccgcggcc gagctcgacc ggccgttgag gctctcgtag cgttcatcga
     1861 cgagcactgg caggtgttcg gagtcgagcc gatgtactgg aggccgaggt cgcatccggg
     1921 cgaccgcgca gcgggccacg ggtctgccct cgcggtgcag ctgccgcgag accttccgca
     1981 ccccgtagac gctgaagttg tcggcgttga cgcggctgat ctgcatcttc agctccgcat
     2041 cccgcacaga ccgagatagc ccgtggctgg tgaggactct gcacgcgtcc accgcggccg
     2101 cggtgttcgc accgccatcc gcgacgacgg ccacgagcgg gcggatgacc gagctcccga
     2161 ccgcggagtg ggtggattgg ttcagacggg accgatgggt attcggcaac cgcaacagcg
     2221 gtgccttcct gcccaagttc gcctggactg gcatcgttcg ccacaagctc gtcaagggcg
     2281 gagcgtccat ggacgacccc gcgctcatac tgcagccgca gttgctgtga ccggtgatcc
     2341 ggttggtcgt tgtgctggcc atgggtgggg gtctcacggt tgacgaggtg catcgctggg
     2401 cggctgggct ggatacgctg catgctcgga tcggccgcta tttccgcagg tcggagccgc
     2461 gcgagcgggc acgccagtat ctggcggata tgggcccggg gtgcagtgcg tgaccgctcg
     2521 cttcgacagg ggcggtcaac tccgaagccg gtctccaact gccggtgggg aggcccacgc
     2581 tgaaggtctg cggcgtaggc gtggtgatgc tgccggggta gtagcgggac gcgacctggc
     2641 cgatcggcac atggtgaacg tgggaaccgc ctgcggtcgc ccggatcttc cggacagccg
     2701 gtccggcgag gagggcaggc ccgttgccgg ccgagggccg caggtggggc ggaggcccgt
     2761 aggagtccga gcggaggaaa gctccgtgca tggcgaagag ggccagcaag tcggcaggga
     2821 ggatgctgca atgccgggag gccgccggtg aataccgacg cgctggagtt cgcgctgctc
     2881 aaggccgagc gccgggtact ggagatgcag accaagctgc actgttgggc gaccgacgat
     2941 cgtgatcgcg ggttcgatga tctgttcaat ctcgttgccg atcccgcgtt cctgctggtc
     3001 gcgtgggatc gggtgaggag gaacaggggc gctcgctcgg ccggagtgga cgggcagacg
     3061 gcccgttccg tggaggacgg gcaaggcgtc gaggcattcc tcgacgaggt gcggtccgat
     3121 ctgagggacc gaaccttccg accgcttccc gtgcgcgaac ggatgatccc cgaaccgggg
     3181 acggccaagc gccgtcggct ggggattccc accgtgcggg accgggtggt ccaggcgtcc
     3241 ctgaagctgg tactggagcc gatcttcgag gcggatttcc tcccgtgttc ctacgggttc
     3301 cgcccgaagc gccgggctca cgacgcgctc gccgaggcgc accacttcgc caagaactcc
     3361 tatgagtgga tggtggaggg ggacatcgag gcgtgcttcg actcgatcga ccacacggcc
     3421 ctgatgggcc gaatgcgtcg ccgagtggga gaccggcgcg tccttgacct ggtttaacaa
     3481 cggctaacac aatgaggcgg atcactgctg cttgccgtgt ccagggcagg agttgagcgt
     3541 tcccctcgtt gtggggacat caccgtggat cgtgtcggat gagctgtggg accgcttgga
     3601 gccgctgctt ccgcagcgtg agcggcgctt tcggtacccg ggtcgcaagc cgctgccgga
     3661 ccgggaggtg ctgtgcggga tcttgtacgt gctgcacacc ggcatccagt gggagtacct
     3721 gcccagggag ctgggcttcg gctcgggcat gacctgctgg cggcggctgc gggactggaa
     3781 cgaggccggc gtctggcagc gactccacga agttctgctc gcagagctga acgcggcatc
     3841 gcgactggac tggtcccgct gcgtgatcga ctcctcccac gtcagggccc taaaaggtgc
     3901 ctctatgggc ttcgtcaagc tgtagccggg gtgggtgact ggtagaaggt gccgtctcgg
     3961 agcattgcga agaggacgtc gatgcggcgt cgggcgagtg cgacgagggc tgcgacgtgg
     4021 tgtttgccct cgcggcgttt ccggtcgtaa taagcacggg actcaggctg ggagagcgag
     4081 gcgaacgcgg ccagatagaa ggcccgtttg agctgcttgt tgccgcgtcg tgggggatgt
     4141 tcaccgcgga tggaggagcc ggagctcctg gtcacgggtg ccaggccggc gtaggcggcg
     4201 aggtggccgg cggtggcgaa gccgctgccg tcaccgacgt cgatgaggat gcgggcggcg
     4261 gtcctgatcc cgatgccggg catcgagatc aggaccgggg aaagagacat ccgatgcagt
     4321 tgatctgtca agcggcgatg gtgagttgtg gggtcggtgt ggtggggaac gcggtgagtt
     4381 cgtcgtaggg ggtgcgcttg gtgaggcagt ggtggaggca gccgagcata cggttgaaga
     4441 ggttgcgctg ggcggcggtg tggcggtctc cgtcggttcg tcgcctgtcg tagtgggctc
     4501 gggcgccggg gaggcggtca ggctggcgaa cgcccagacg tagccgaccg aggccagacg
     4561 ctggttcttg accctgcggg ccatgaccgc gaggcttctg ccggacgccc gggtgaccgg
     4621 tgcggcccgg cgaaggcttt gaggcccttc gcgtcggtga atcgagatcg gtcgtcgccg
     4681 atctcggcga gcacccgggc gccggtgaga gacccgagcc ctggaaagct ggtgatgatc
     4741 tcggcgtccg ggtgcgtgtc aaaagactcc accgtcgctt cggtgaggtc gtcgacgctg
     4801 gtgcaggcgg cttcgagctg tctgagtagg gcgatggcct ggcgtcccat ggcttgctcg
     4861 acctgtgggg gctggcgcat ctgcgggact cgcagggcgt ctcgcagtcg ttcgacttcc
     4921 gcctcgatgc cgcgctggcg gccggccttc ttcagcagcg agcgcagctg ggcgcgggtg
     4981 agcttggctg cctgctcggg gtgggggccg cggccagcac ggcgcgggcg acactgctgc
     5041 tgatcccttc gcggttgtgc tggaaggcag caaggtagcc ggggaagtat tcgcgcaggt
     5101 gggaacggag tttgttgccc gcctgggtgc ggtcccagac cgcgtcctgc tgggcgcggg
     5161 ccaggacagc gattgcttgg gcgagctcgc tgtcgtcggg cagcggccgg tgtgcggcct
     5221 tgtccgtgcg caggatgttc gcgagcacca tggcgtcgag gtggtcggac ttcttgcggg
     5281 tgaccgtgtg gcggtcgcgg tagcgggcgg cggccattgg gttgatggcg tagacgggcc
     5341 ggccggtcgc gcggaggcag gcgacgagga ggccgcggga ggtctcgatc gcgatggggg
     5401 ccggggcgtt cgcggtgtcg ccgtgggtgg tgaggagctc gaggagctgg tgcaggccgg
     5461 cgaggtcgtc ggtgatccgg gcccttgcta acaaggtccc ctcatggtcg accagggcga
     5521 cgtcgtggtg gtcgctggcc caatcgattc cgcaggtgac ggtcatcgtg tcgtgttcgt
     5581 cctctcggtc gggggcgtgc tgctggtcgc agccgtgcgg gggcacgcgt ctccctaatg
     5641 gaagggctca atggccctgc atccgatcag ccgtttgtga ccccagcggc tcacagggcc
     5701 ctcggtctgt tccagagctc ggcagctcca ggcgtggtga gaggtgcccc ctgtgggcgg
     5761 ctcggaccac aagcgtcaac gatccgatca tcggggcgga tgcggccgtc gtacgggctc
     5821 gtgacagtgg acggtcccgg aggccggctc ttgaccaagg gatccagtcc cagggggtgt
     5881 gaacggcttc tccggaaccg accaccgtca cgagaaagtg atgtggggcc cgcagtctct
     5941 ttcagggcct cgatcggccg gggtgggcct ggcggtgccc cgcatcactg cccattaggg
     6001 tgggcctcca gaagctcctc gatccttgcg gcgaggagtt tgcgctggtc aaggacggac
     6061 gtgagggaac tggcgaggct ggggacgatc agtgcggccg cgtcggtgcc cgggacgacg
     6121 acgctctgtt cgtcgagtgc ggtgaagatg tcctccacca gccgctcggc catccgcggt
     6181 gccttcggcc gtatcagggt gaccagtcgt cgccttccgg ctttgcgaat ctgagccggg
     6241 gagccgaacc gctccagcag cctgagcacg gccgggtgct gaatccgtgg gcccaagacc
     6301 cgttccagtg acggatggat ctgagtgagc aggccgcgga gccggttggc gatccgggtg
     6361 gactcgcccg ccaggtcgtc gtcgaagccc gcgatcatcg cgagctcggc gaccgtctca
     6421 tcagcgggat cgaccgcccg cagggtgtgg ggcatcgctc tggcggcgtc cgcgatgacg
     6481 aacgcgtcac gggcatcggt cttggcctca ccagggtaaa gatcggcgat ccgccgcatg
     6541 gtcagcccgg gcaagtaggc gacctggcaa cctgcatccc gggcgactgc caggggcaga
     6601 gctccgatgg aagctggctg gtcgacgacc atcagcacag tcccgtgcct ggcccgcagc
     6661 ttgtcgaaca gctcccgcag cctcggctcg ctgttgggca acggcttgtc gaacaccttc
     6721 ttcccagcgc gattgacagc ggcggcgtga tgttcgccct tgccgacatc cagccccaga
     6781 tagacgccga tgccagattc gtccgtcacg accgtcgctc ccgccctcgc ctgttccccg
     6841 gcctcacctg cggcatcagc gtgccggcat ccacgttacg aagagactgc cgtacccggc
     6901 tgagggatcg gcgctcgtgc ctctaatcag cggtctgcca atgcctccga caccggcgac
     6961 accacctttt cgatcatctc gactgggggc tcaagtcata ccggggccga aggccgggag
     7021 cctccttgcg aggccacgaa gaaggtaacg gggcagcaca cgggcccttc gccggtcgac
     7081 cgcgggcggg ccggctcgaa gcaccacctg atcaccgacg ggcatggcac acccctcgcg
     7141 gtcctgttga ccgggggcaa ccgcaatgat gtcacccagc tgttgcccct gctcgatgcg
     7201 attccgccgg tccgcggccg ggtgggccgt ccgcgccgca agcccgacgc cctgttcgcc
     7261 gaccggggct acgaccacga catctaccgc gaccgggtcc gcgaccgagg catcctgccc
     7321 gcgatcgccc ggcgcggcac gcgacatggc accgggctgg gtacctaccg gtgggtgatt
     7381 gagcgcagct tcgcctggct gcacggcttc cgacgactgc ggatccgctg ggaacgacgg
     7441 gctgacatcc acgaagcgtt cctcaaactc gcctgctgcc tgatcaccca ccgacaactc
     7501 ggctcattgt gttagccgtt gtaagagacc gtttagctgg tcgaagacgc cttccttctg
     7561 ccatgcggcg aagtagccgt agacggtttc ccagggggcg aagtcgtgcg gcaggtagcg
     7621 ccaggggatg ccggtgcggt cgacgtagag gatggcgttc atgatgctgc gcaggtcgtg
     7681 ctcgggcggg cggccgatgt ccagaccctt gcctctccgg ctggcccgcc aggcggtgag
     7741 tgtggggccg atcagttccc agcgcgcatc ggacaggtcg ctgggatacg ggcggtgtcg
     7801 cgtcatgttt cggtagtacc gtcgagcaga ccgcctcccc agggcgcaaa cgaggccaac
     7861 cgggggcgtg ttgggatcag acgggagcga acggaacgaa acgggttgcc gactgtcgac
     7921 acgaatccca cacctcccat cagacacgcc tgccccaaag gtcccgtacc gggccggctc
     7981 gcgaaacgcc agcaatcaac cattccggga taaaacgctc tttcaccgcc tggcgggcca
     8041 gccggagagg caagggtctg gacatcggcc gcccgcccga gcacgacctg cgcagcatca
     8101 tgaacgccat cctctacgtc gaccgcaccg gcatcccctg gcgctacctg ccgcacgact
     8161 tcgccccctg ggaaaccgtc tacggctact tcgccgcatg gcagaaggaa ggcgtcttcg
     8221 accagctaaa cggtctcctg cggcgcctgg tccgggagac cgaaggccgc cacggcgagc
     8281 cgagtgcctg cgtgctggac gcgcagagcg tgaagacctc cagtaatgtg ccggcggcag
     8341 gccagggcat cgacgccggc aagaaaatcg caggccgcaa gcgccatatc ggggtagaca
     8401 ccctcggcct gctcctggcc gtctgggtca ccgcggcgag cgtttccgac aacgccggcg
     8461 gcatgcacct gatgtcccac atcgccgcca cccacccgcg tgtgaccaag gcatgggccg
     8521 acaccggcta ccgcaccaaa gccatcgagc acggcgcccg cctcggcatc gacgtcgaag
     8581 tcgtccaacg cgaacccgga accaaaggct tcaaggtgat cccgcgacgc tgggtggtcg
     8641 agcggacctt cggctggttc atgcaccacc gccgactcgc ccgcgactac gaaacccacc
     8701 cccaccgctc cgaagccatg atccacatcg ccatgatcga cctcataagc cgcagactca
     8761 cccgcgaatc caccccgaac tggcgcgaca cctgaagccc gaaccaaaca accctgccgg
     8821 gataaaacgc tctttaaggc cagcgtacgt gtcgcggatg atcagccgga tgccggacag
     8881 gccacaggcg atcagcaagt gcaggaaggc gagccagcca ggcgccgccc ttagctctgg
     8941 cgccagcaat gccgagggct ctcgcggtgg ccggtcgtat tgatgccgcc ccgtgtagct
     9001 tgctttgtag caggacacaa cgtgggcact cgcgtcctcg cctggccagc ggcacccgta
     9061 ggttatctgg gcgtcagacg gtcaatgcct gcccgtccgg tggttggtat cagcgttggt
     9121 ctaccatcga tcgactgagg caaccaagag atcggcagac gcagtgactc tcacagacaa
     9181 ggctggaccg cagaccagga gccgtcaatt acgggcggaa gtcggcaggt tcggcgtgat
     9241 tggcggccta gggtggcttg tcgacacgct gacattcaac ttcttcctga atattttggg
     9301 actagcctct gtccggtcgg gacttctggc gagcaccatc gccatagcgt tcaactattt
     9361 agggcatcgg tactggacct atcggtcgtc cgccacggta agccgttcac gcgaggtcgg
     9421 acttttcgcc ctctttagtg tcattggcat ggcgatccag aacggcgtgc tcgctatttc
     9481 tcattacgga ttcggatata cttcagcttg ggctgacaat atcgcgaaga acatggttgg
     9541 gctgggagcg gccaccgtct tccggttctg ggcgtaccgc aacttagtat ttcacgttac
     9601 gcatcaatca ccggccgacg cgcgatgacg tgaccagcat aggaggcgaa ccttcgttgc
     9661 gccgcacttc atgatcagcc agtggctcgc ggcgaaatct accttttggt gccggtccgc
     9721 cgacgtccga ccctcactga acagcgaagc tcggcccgac tccgagcaag atcgctctgg
     9781 ctggaaacct tctggatcga gcgcgtgagc gaatgtaggt ttcgtgttga tcgcaacccc
     9841 tgagcatgga ggatcgtcat ggaaccccag atgactgagc ttcagccgga ggcctacgag
     9901 gcgccgtccc tcatcgaggt gggcgagttc tcggaggaca cgctcggctt cggaagcaag
     9961 ccgctggaca gcttcggcct gaacttcttt taggccaaca gtgagcaccg ggtttcttat
    10021 cctgccggac tctgtcggta ctgatgccct ccgcgacagg cttccgttgc tggcgttacg
    10081 cacgcttcgg tacccatcgg ggcggccgtg gatcgtcggc agatgggacg ctgaggagat
    10141 catgtccgcg cgtgtcggcc cggtgcacgt ggtggtgatc gggttttgcc cggtcaccac
    10201 caccgaactg acctcgttga tcagtcggat ccacaccgtc tctgacgtga atcgtttggt
    10261 tgccagtctg cctggaagct tccacctcgt cgccgcggtc gggcggcagt tacgggttca
    10321 gggcagcatc acgggtctac gcagaatcgc ttgggcaaag agcgacggcc ataccttcgt
    10381 ctccgaccgc accgacatac tcgccgacct gacgaacgca aaaatcgacg attctctcct
    10441 cgccacgaga gtggcatgcg gcgggatggt ccccccaccg ctgcgtgaac gcagtatgtg
    10501 gcttggcgtc aactctctgc cgcccgaccg ctatctcttg gtcgagggcg ggcagcggac
    10561 gcgcgaggtg aaatggtggc agccgccagc accagaaacg actcttgctg agggcgcctg
    10621 cagagtcagg gaagctctcg tatcggccct gtacagcagg aaccccgtcc acggccgact
    10681 cagcgcggac ctgtcaggcg ggcttgactc tacctcgctg gcctttctcg ccgcccggac
    10741 cacgcctcat ctactcacac accgctgggc ggaggccgag gcgggcaatg acgacggcaa
    10801 gtatgcggcg atcgcggcgc gggagttgcc caatgctgaa caccttgtca ttccgcaatc
    10861 agatataccg cctgtcttct ccgacccgca cctgaacggc gaccccgagc aaccctatct
    10921 tttcgcgcgg acggctgccc gagccgtgta tacggctcgt atgctagtcg cgcatagttc
    10981 cacgagacat atagccggcc atgggggaga cgaactcttc tacaagttcc ctggatatct
    11041 tcaccctctg ctgcgtcggc gtccactcac cgccatccgg catattcgcg cccatctggc
    11101 gctcagccgg tgggacagga aagccaccgt cgcacaattg ctggacacca gtggtttccc
    11161 ggattggtgg aagcggcagg cggaccaact tactgcacct ccaccaggcg gacgttttcc
    11221 gcctttgggc tggggattta tgcctctgca cgcccagccc tgggtgacag gggaggcgct
    11281 gcacgcggca cgcgccacac tccgcgaggc ggcggaagag gcccaccccc tcgccccgga
    11341 ccgggggcaa caccagtacc tgctggccct gcgtaccacc gcgccggcat acgcacagct
    11401 cggtcgccta ttcgagcggg cgggtgtccg gctggacttg ccatacctgg atgaccgggt
    11461 cgtagaagcg gccctgtctg tccggctgga ggagcgggcc cacccctggc gttacaaacc
    11521 acttctcgcg gaggccatgc ggggtgtcgt cccggagagc atcgctaccc gcgtcaccaa
    11581 gggagagttc agtgccgatt tgagtctcgg gttacgccgg aaccgcgcga gcgtgctgga
    11641 ctttctcgcc gattctgcca tcgccaagag ggggctgatc gacgtcgaca ccctgcgtcg
    11701 cctgcttctc gcgccccagg ctgatcactc ccgaaatata gctctcgaac acctcgtggg
    11761 ctgtgagacc tggctccgca ccaccccaaa gagacaagat gcgcctgcac cctgatatcg
    11821 tcatcgcgga aaccgaagac ggtgcggtcc tactacacca aaggaccggc cgctactggc
    11881 agctgaacac cacgggcatg gcggtcatcg aaagcctgac ttccggtgag accctcgccg
    11941 agatcacgca ccgtatggcc aagcgttacg gcttgcccgc tgagcaggtc cggcaggacg
    12001 tcgaagccgt cgtccatcaa ctacacgcgg cccagatagt ggagagcacc tcgtgagtac
    12061 ccccgccgcc ctggtcaagc gcagaaaact gcccttccat cgcagagtgc tgccgctcgt
    12121 tgctgtcggt gttgcccgcc tcctcagcag gacaaagcct gcacggctgc gagccatcct
    12181 gagctacgca cgacggggtg ccgcgccggc cacggtggaa caggcgatgg ccgcgcgaca
    12241 agcggtcgtc gccgtcagcc aacggtgcgc cggacaggcc tgccttcagc gttccatcgc
    12301 gacggcactg ctctgccggg cgcgtggatc ctggccgacc tggtgcaccg gggtacggac
    12361 cagcccgttc gaagcccatg cctggatcga ggccgaaggt cggctcatcg gcgagccgta
    12421 cccggacggt cactatcggc ctttgctgac cgttcctccg gtttcctgac accggtcgac
    12481 acgaccgacg acggtcggct gccgactcac cgtgcacctc cccggaccac gcccgccgcc
    12541 tgatcgtggc cagccaatgc gagagccagc gaccagacgg cccggccgcc cccaacgcgg
    12601 agacgcccgc ccccgtggag gcccccgggc cgggactggc cggacgcacc gatcccggca
    12661 tgcggcggga ccgggttcag ccgcagtcgt tccggttgat cttcagggag cgggtctggt
    12721 cgttgaggtt gtagccgcgc aggtcgtgga tggatccgcc gctgcgggtg acgcacaccc
    12781 agcggccggc gtggttgcgc ttttcgtaga tgcgggcggt gcggtcggag ttgttgcgga
    12841 tggagctgcc gcggtcccgg atcgcggagg gcaggtcctt cacgctgccg tccacagccc
    12901 ggcgcaccca gggctgcccg ccgaagttga tctcggggta gatgcagacg tagccggacg
    12961 ggcagtcgat cgcggcctgt gccgcatggg gctcgctgga agccgaggcc ggagcggtca
    13021 gcggtgtgag ggcgagggcg gcgacggccg cagcacgcat caggttccta atcacgtact
    13081 acggatactg ctcgccgccc gtgagtagcg tcgcttgcgg cccgcgttca ctccagcgga
    13141 gcagttctcc atggcctccg cgatgcccgg gtccacccgc tgctcgggga cgacggccag
    13201 gtgtgcggcc aatgtgcggc ggcagccgcc cgagtatggc agaccagaac agggcccagt
    13261 actgtgggta cgggtacgta cccgtaccct gcttgtctgg agggagcctg atgatgtctg
    13321 acgcgaacgt ccgtatcccc gaagaggccc gtgaccggct ggcggccata gcggcggcgg
    13381 agggcatgtc gttgcgtgcc tatctggctc ggcttgccga aactctgctc accccggagg
    13441 agcgtgccgt gcgggcggag caggccaggg ccgcgttgaa ggagtggaac ggctacgcgc
    13501 ccactcccgc cgaggagcag gacctcgaca gcgagctgga ccggcggctg tcccgggcgg
    13561 gggcccggtg agcgacgccg tgcacatcgt cctggacgac accgcgatgg ccgcggccgg
    13621 ccagggcaat gtcctggcct cccgcctgat ccaccgcgcc catgcccagg cgggctggta
    13681 cctgtacgcc cccgcgtgtg cgctcgtgga agccgaccgt gcccggcccg gcacggcgga
    13741 gcacctggcc gcgctgccgg gcatcacggt cctcgagctg gacctcccgg ccgccctggc
    13801 cgtcgcccgg catgacacct gggcggcggc acactgccag tacgcggccc agccgactcc
    13861 ggaccgcccc gacggtgcgg tcatcgccac caccgtcccc gaccggtgga tcggtgagcc
    13921 ggtccgcgtc ctggacctca ccccctgacc ccgcgcccgg atcacccgcc ggcgcgaaga
    13981 cgggctcggc gggtatggac gaggcgttgc cagcgggcgc ggacggcttc gggcccgtcg
    14041 agccagtgcg cggcggaagg gccgggcagg ggcaggccgc ccatgtagtg ggcgatgtcg
    14101 gcgtagtagg cgtagtcgcc ggtccgggcc aggtcgcgca ggcggccggt gacggcgcgg
    14161 accttgtcct gctcgccgag gacggcgtgg tggaaggcca gggccagttc cagagcggct
    14221 tcggctgcgg tgatgccggc gtcgtggctc tcggcgcgca ggtcgcgggc ggcttcgagg
    14281 ccgcgcggag ttccggcgtc gcggacgagg gcggcgatcc gcacggtgag gttggtggcg
    14341 cgcaggtcca ggccggtgag gagctgctcg gcgaggtgga gctcgtcgtc cgcggtgtcg
    14401 gggtcggtga aggccaccgc gaaggcgcgc tgggcttggc tggtggcgcg ttccccggcg
    14461 acgccgtgct gctcggcctg gttgcgggcg gctgcgtagg cggcggccgc gcggtccatg
    14521 tcgccgtggg gccagaggat gtcgccttcg acgcggtgct ggcggccggc ccagccgagg
    14581 gcctgggcgg tggcgtgggc ggtggggaag tcgccggcga ggcgggcgag gtgggcgagt
    14641 ccccggcggg cagcgggggc gaggcgcccg cccctgtcgg cgacgagctg catcccgtgg
    14701 cgggaggccg cggagtcgcc gaggtcgcgg tgggccttgg cgaggtagta gacgcccatc
    14761 tcgtgcaggt cggcggggag caggccgctg ccggtgacgg cggcgaggcg ggaagcggtg
    14821 acggagcggt gctcgcgctg gcggcgggcg agggcggtga ggagttcgac gagcgcgtcg
    14881 gccgacgtct ccaggccgcc ggtgcggccc ggccgggcgg gtggggcgat cggctcccac
    14941 acggagtcgc tgacgtaggc ccaggctgcg tcggcgagcc agcccagctc cagacggtag
    15001 tcccgggcca gggtgaggcc ctggcgcagg cagccgacca gcagcatccg gttgcggccg
    15061 ccggcggcgg tccactgggt gccgagggcg gccagtgcgc gttcggcggc ctgctgccag
    15121 tcgccatccg tccagcggtc gtcggtggcg tcgtcggcgc tgcgcagggt ggagcggatc
    15181 agcccgtgca ggtggtaggg ccacagcccg aagacgttct cgcggacgaa gggccgctcg
    15241 atcagccgct gcgcgggcgc ctggtgggcg aggccggcgg cggcggtggc gagggtgaga
    15301 tcgaaggcgt ccagcaggct gacggagcgc aggacgtgcc gttcgtcggg ggtgaggtcg
    15361 gacagagtgc gggcgatcag ggcgccgaag tcgtggtcga agtcggacgg gaccggttgg
    15421 cgggtgcggc ggatctccag gaagcgcagg acggacaggt cgaggtagag gggcaggccg
    15481 tgggaccggc cggtgatgac ctggcggatc tcgctgctga tgagcggctg gccgtcgcgg
    15541 gagaggcggc gggcgaggta gtcgtcgcag tcctcgggtg agaagtctcc gaccaggacc
    15601 tgccgcccgc gccctcgtac ggcgcctgcc cgcgcggccg ggaccgtgga ggcgggcacg
    15661 gccaggccgg gccatgcggc cggcccggtg tagtcgagct ggccttgcag ggcagggtcg
    15721 gcccactgca ggcgcgagcg gccggtgacg atgaagaagc agttgggcat cagccacacc
    15781 acccgctgga tgagccgctc caggtcgcgg tgggtgcggt cgccgacgtc ctcgaaggtg
    15841 tccagcagga tcaccggcgt gacgcgcttg tccgccggga gctggacgag ctcccacgcc
    15901 agcaggtgcg ggtagaagga gagcgcctcg aggtcgggct cggtctccag caggtcggcg
    15961 agccgggcgc acccggcgag tgcgcggacg gtctggcgcc gctcgcgcag ggcgcggacg
    16021 agggagccag tgacctgccc gacggcgctg ccgatggtgc cgggcaggag cagggtctgg
    16081 gcgatgtcgg ccatcgcgga ctgcatctgc tgcggcatcg ccttgccgaa ccggccggcc
    16141 aggccgccgc ggcgcaggta ctcctccagc ggctcgccgg gatgctgggt ctcccagtag
    16201 cggcgcagcg ccaggtcgaa ggcgggcagc gggcggccca gtgcgctcag ggcggcccgg
    16261 atggtcagca cgagctgctc gaagtcggtg ccggcggagc gggcgaggtc gatgcgcacg
    16321 ggcaggatcc gctcaccggc ccaggtgggc tcgccccact gcgctggccg gtgttcggcg
    16381 ccggccagcg cggcctccag cttccgggac agggtggtct tgccgatccc gccgaccccg
    16441 tggaacacga gcacgttgtc gcgcggcgcc tccatgtcct ccacgtcgaa ccccgcctcg
    16501 gcggtgcggc gcaggtgggc ggtgagcgcg gccgcgacga tctcccactg aatctgccgg
    16561 ttcgtgaacg cctccccggc ctccaggctg cggtcgttcg tgctgaacag cgcccgcaga
    16621 tcccgacctg ccacgaccca cccccgaaac gatgatcact tgatgcccaa cctatgcccg
    16681 cgcaagtccc cttggagaag catctcccgc aggcacccgg ctgcgaagga gctctgcccc
    16741 tgctcctggc gcgtcgcggc gctgggccgc tggttccggc cagggagaca atggccgttt
    16801 cacatcaaga tcaacacgaa ggtggtggac cgtgtccgac actcccagct ctgacttctc
    16861 cggcttggag ggcggcgagg agcaggcggc cgaggaggcc atccaggagg tggcgaactg
    16921 gtacaacatc cagctcctca ccgagcgccg cgcgccgttg cccgacgagg agcggatcga
    16981 ggagctgaag gccggccggg aggccgccct cgcagacggg gcccagctgg cgacggcgga
    17041 ccgggaggag gccggccgga tcgccgccgt ctacgcggcg cggctgaagg agctcaagga
    17101 gcagtagccc gcagtcctgc tgggtacggg caggggccag acgggcgggt gcggccggcc
    17161 gaggcgggcc ggctgcaccc gcgcgggcat cagcggccgg gcgagtgcgg cgatctcgtc
    17221 cagctcctcc cggtgccgcg ggagcgcccg gcacaggccg tggtggaggc ggaggaaggc
    17281 cgcggcctcc tgctcggtgt aggggcggag ccgctccgct gcgagcgccc acgacgcccg
    17341 cccggcgctg ccggcttcgt ggcgcagcag ggcctggccg tcccgccgga tcaccgtgat
    17401 ggccgtaatc tgcgggtgct gctcggcgac ggcgacgatg tcggcgagcg cgctaaagca
    17461 ggtgtcatgc ccaaagcggc tggtgaaccg gccggtgccg ccccgctgca gggcacgggc
    17521 atagcgcagc gcggtcgcga gccggctgtc agctgcgcgc acggccagga cgacaagctc
    17581 gacggagtag ccggcggccg cgaacggcag cgcactggcg aggaactcct ccacgctccc
    17641 gggggcggcc tcgaccaaaa cgtcgccgcg ccggtcgcgc acgtactgct cggcccaggc
    17701 gaaccaggcc cggtagtcgg agcggatcgc cgccccggcg cctcggggat cgtcgcgcag
    17761 cagatggaag tagtcggggt gctgggcctt gaggtcgtca ccgaccaacc gggtcgtgcc
    17821 aggacgcatc gcgcggcgga ccatccgggc ggccagcagc ttgcccgcac cgggctgccc
    17881 catgacgtag acggcgcgcg gatcgtcccg ggtgatgatg ccgctcaggt aggacgggac
    17941 gatcagctcg tcgaagatcc accggtgctc ggcggtggag aggcggtggt agtcgacgcc
    18001 cggtgcgcgc cttcggggct gtgcgatgcg gcggaccggc tcggcgagtg cggcggcccg
    18061 cctcgcgtcc cgtatgacgg cgagacgctc atcctcaccc ggcacatcgc ggtgtacgcg
    18121 tacctcggcg cgggcgagct cctggtggaa cgcggccgtc tcccgggccg tccaaggacg
    18181 ggaacgcccg cgggcgacgg ccgtgccggc agcgggccga cggcgccacc cgccctcgac
    18241 gagctcgttg tcgtacagca cggtgctgtc gcgggtcacc acggtgatgc ggtcggcgag
    18301 ctgctcggcc tcgatgaccg cgagcgtcgt cagcatgttc ttcgcgcagg agtcgtggtt
    18361 ggcccacgac acgtaccggc cgcccgcgcc gctggcggcc tcggcaagga agcggtcgag
    18421 gatcccgagc tggctccacg cctctggcgt cgcgagcgcg accacctcga tgcggtgccg
    18481 ggagcggcgg tacgccgccg acgactcacg aaattcgtcg gggtcagcga gggcggactc
    18541 gacgaccgcg tccagaccgt ggtcgcggac gtacttttcg acggcggtct gccagcggct
    18601 ggtgtccggc cgaaccttcg cgccggcggt acggacgtcg gcggccagtg ccgcggcgta
    18661 gtggcggtgg gcggccttgt agaggtcgcg gccgacccgt accgcgccgc cacgctgccc
    18721 gagcgccgcc tggatgaggt cggcgacctt ggtcttcccg gctcccggtt ggccgccgac
    18781 gaccaccacg accggacggc cctggggcac ggcgctcgcg gtggccgcag gcaggatcac
    18841 gctccccagg acgtcctggc tctcgcgggc cgagagcacg gcgcaggcgt ccaggtcttc
    18901 cacgggggcc tccagcctca tcggcttccg tactcgctag atcgttccgc ctcgaccata
    18961 accacaacga gtaatccatg tgaaatccag cgcgaaatcc aatgagcaat tgaggtaggg
    19021 tgtggcatgg aggtgagctc tgtgcccact gagaacgagc tgttcagcgc cgtcgatgcg
    19081 ctgctggaag aggtcgccca ggacgacctt ccgccgcccg aggagcgcaa gcgtctgcgc
    19141 gaagccgccg gactgagcca ggaacagatc gcgaaggccc tgaagagccg acgagagacc
    19201 atcggcaact gggaggcggg cgtgaccgag cctcgaccgc ccaagcgcgc cgcctacgcc
    19261 cggctcttgg aaggcctcgc cgcacgcttc cccgccccgg ctactgacgc gcccgccact
    19321 gccccggcgc cggcgatccc agaggcgttc accggcccgg ccccagcccc ggcactcgag
    19381 ccggttccgg cgcccgccag cgccccgccg tcacctccgg cgacaagcag caccaggccg
    19441 tcggcgtcgt cgcggcgtcc gggtgcgaag aaagcgacga agaggccggc caccacggcg
    19501 gccgcggacg ggcggttcga gaacgggccg ctggccgtgg tcgacgtcga tgaccacggc
    19561 aaggtggtgg cgtactgcgt cggcggcctc gtcctggacg tgcccgtcaa gagcgtcccg
    19621 gccctggtgg actggacgct gcgcgaggcg aagctcgggc agccgaagct gtccgggccg
    19681 ggcaaggacg ccgacccgct gctggtgctc accgaggccg ccttggagcg ctacggcctg
    19741 cccacgacgc tcaccgagga ggagcgcctc gccgggcgcc tgccagaggg ccacaaggtc
    19801 atcaagcagc tcgcgcgcgc ggagtggaag ctgaccaagc gcggcttcgg cccgtgggcg
    19861 cggatctacc gccccgccca ggggtcggag cgggcctgcg tccagctctg catcccctcc
    19921 tggcacgcgc tggacacccg gcactggggc ccggccggtc ggctcccgcc agccgacctc
    19981 gcccgggtcc tgggcgtgta cgcctcgcgg gtgatgacgc cgcgcggctc cacggccgtg
    20041 accggcctgg agctgatgac cgcgctgcac ccgccgaccc gggcctccga gccggacgcc
    20101 gacggcaagc ggcactccga gcacaacccc ggctcgctcg gcaaggacgc catcgacccg
    20161 atgaactggc cgccgtgcga ggtccccgac ggccacccgg tcctccaaaa cctgccccgg
    20221 ttccacgtgc gcggccccgg agagaagctg ttcgaggagg cgtacgactg ggcgcggccg
    20281 atgaccgatg ccgagtgcac cctgcggcac ctggtcggca tcgacgtcaa catggccttc
    20341 gccgccggcg ccaacggcct gaccgtcggc ctcggcgccc cgacgcacat cacgaacccg
    20401 gtgttcgacc cgaagctccc cggctcctgg ctggtcgacc tctcccacgt cgacctgtcg
    20461 aaggtgaagg tcggcaagga gtgggtggag ctggacggca gcttgctgcc gagcccgttc
    20521 acgccgaagg gcgagcgtcc gaccggcccg gcctggtacg cgacgcccac cgtcgcctac
    20581 gcggcagagc tcggctacga ggtgcgcccg atcgaggcgt gggtccggta cgacaacggc
    20641 cgctacctgg atagctggta ccagcggctg cgcgacgcct atctcgccac gatggccgac
    20701 ctgggcgtcg atgccgacct cgccccggcc gacttcctcg ccgcgatgga cggctacaag
    20761 agccgtgacc cggagctggc gatcgtcgtc tcggcgatca aggcgacggt caagggcggc
    20821 ctgggcaagc tgcgcgagcg gccccggggc gagggctggc gccccggcga gccgtggcgg
    20881 gccctgtccc ggccgacgtg gcggccggac atccgggcgg cggtcatctc ccgcacccgg
    20941 atcaacctgc accgcaagat cgtcaagcac gcggcgttca ccgggcagta cccggtcgca
    21001 atcctgtccg actgcgtcgt ctacgcctcg aacgggccga gcccgctgga cttcctgccc
    21061 taccgggacg gcaagccgct gcccggcggc ttcaagctcg gcatcaaccc cggcctggtc
    21121 aagcacgagg gcacccagac cgtcctgtgg ggcgaggaag tccgcgagcg gttcaacgcc
    21181 ccggagctca acctcgcccg gtacatcaag gacggcaccg tcaccgacat cgacaacgga
    21241 gagtaggagt aggccacgat gagcctgttc ggggacggcc tggaggccgc ggtgcagaag
    21301 gcgttcaccc gcccggcgcc caagagcgcg ggcgcgcaga tgcggtacct ggtcaagcag
    21361 ctcaaaggca ccaaggcggt cgcccagatg ctgcgggtct cccagcgcac cgtcgaacgg
    21421 tacgtgaaga accagatcaa gaaaccccgc ccggacctcg ccgcgcgcct ggagcgcgag
    21481 gtgaagaagc ggtggcagcc gcagatcagg gccaaggccc ggcagaaggc ggcgaccacc
    21541 ggcggcatcg tcatcgacac ccgcgcccgc ctcggttaca ccgcgccaat cgggtcgacg
    21601 gaccaggacc gcatccggca cctgaccgtc gccctgccgc ccgtctacgc cgcccgcctc
    21661 ttcgacgcgc aggaggccgg tgccaccgac caggagctcc aggagatcgc ggccgaagcg
    21721 ctcaaggaga tctacttcca ggacggcggc cgccgtgccg gctccctgga ggaggtgcgc
    21781 ttcacggaca tcgagcacct cgagttcgac ctgtagcagc cgcaccccga acagcccgcg
    21841 agcccggacc gcatcggtcc gggctcgctc gcgtatccgc gggggtcgga tgttcatgca
    21901 cgcgtgccgt gttcaacgcc gccctcgcgt cggcggttac ggttcgccga agccgtgctc
    21961 gaagcccttg aggacggagt ccagttccgc ggccgcgcca cacagcgagc acagccggat
    22021 gcccggctgc tgcgccacgt ccaggggccc gctccagcgg cagcaccggc gccccggccg
    22081 gcgcctcgtc gcagtcgaca gcgtgcacga caccgccccg gccgggcccg cggccgccgg
    22141 ccttcgcaat cacccagccc gacgggcggc gcggcccgag gacctggtcc acgacggacg
    22201 gcttgggtag gtactcggtg ggcacctggt cgtacgagac gccgtccacg ggccgcacgt
    22261 ggtccggagc gcggacccag acgcggtact cggcaggctc caccgagtcc ccatactggt
    22321 gaagaggcag tattccgaac gtgcgctatt cggtttcctc tgtacgagca ctaatcagag
    22381 cttcagggca ccaggggacg gctcgttccg ccggtggcca gggctctggg aggtagcggc
    22441 ttacggacct acgatgagcg gcatgttgc
//
