Select genomic region:
Overview
1.1
1.2
2.1
2.2
3.1
3.2
4.1
4.2
5.1
5.2
7.1
9.1
12.1
22.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LAQP01000001.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | opine-like-metallophore | 252,530 | 274,628 | High | bacillopaline | other:other
Region 1.2 | NRPS | 318,732 | 365,709 |

NZ_KQ040792.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii | 490,797 | 519,426 |
Region 2.2 | terpene | 608,724 | 629,605 | Low | carotenoid | terpene

NZ_LAQP01000004.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | NRPS,NRPS-like | 1 | 25,578 |
Region 3.2 | terpene-precursor | 363,162 | 384,088 |  |

NZ_KQ040793.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | proteusin | 348,569 | 368,811 |
Region 4.2 | lassopeptide | 386,456 | 411,239 | Low | paeninodin | ribosomal:unmodified

NZ_KQ040794.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | NRPS | 131,234 | 193,787 | High | fusaricidin B | NRPS:Type I+PKS
Region 5.2 | NRPS | 398,045 | 424,750 |

NZ_LAQP01000013.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | NRPS-like | 48,869 | 92,573 |

NZ_LAQP01000015.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | NRP-metallophore,NRPS | 32,153 | 84,430 | High | bacillibactin | NRPS:Type I

NZ_LAQP01000018.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | terpene-precursor | 49,920 | 72,301 |

NZ_KQ040797.1 (Paenibacillus wulumuqiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | NRPS,NRPS-like | 1 | 5,905 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | opine-like-metallophore | 252,530 | 274,628 | High | bacillopaline | other:other
Region 1.2 | NRPS | 318,732 | 365,709 |
Region 2.1 | lanthipeptide-class-ii | 490,797 | 519,426 |
Region 2.2 | terpene | 608,724 | 629,605 | Low | carotenoid | terpene
Region 3.1 | NRPS,NRPS-like | 1 | 25,578 |
Region 3.2 | terpene-precursor | 363,162 | 384,088 |  |
Region 4.1 | proteusin | 348,569 | 368,811 |
Region 4.2 | lassopeptide | 386,456 | 411,239 | Low | paeninodin | ribosomal:unmodified
Region 5.1 | NRPS | 131,234 | 193,787 | High | fusaricidin B | NRPS:Type I+PKS
Region 5.2 | NRPS | 398,045 | 424,750 |
Region 7.1 | NRPS-like | 48,869 | 92,573 |
Region 9.1 | NRP-metallophore,NRPS | 32,153 | 84,430 | High | bacillibactin | NRPS:Type I
Region 12.1 | terpene-precursor | 49,920 | 72,301 |
Region 22.1 | NRPS,NRPS-like | 1 | 5,905 |

No secondary metabolite regions were found in these records:
  NZ_KQ040795.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000014.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000016.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000017.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000019.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000020.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000021.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000022.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000023.1 (Paenibacillus wulumuqiensis)
  NZ_KQ040796.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000026.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000027.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000028.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000031.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000032.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000033.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000034.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000035.1 (Paenibacillus wulumuqiensis)
  NZ_LAQP01000036.1 (Paenibacillus wulumuqiensis)

Compact view
NZ_LAQP01000001.1 - Region 1 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 252,530 - 274,628 nt. (total: 22,099 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
WH45_RS09340: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.82 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0002489.2 |  | 0.52 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000513.3 |  | 0.43 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000571.3 |  | 0.41 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.82 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0002489.2 |  | 0.52 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000513.3 |  | 0.43 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000571.3 |  | 0.41 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.87 out of 27.55
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.23 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.69 out of 27.78
Confidence: medium
Additional weak hits (8):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.01 out of 36.54
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.68 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.17 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.42 out of 31.73
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.61 out of 29.38
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.65 out of 33.14
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.59 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
MexT | Global virulence regulator
RpoN | Regulator of nitrogen assimilation and virulence

NZ_LAQP01000001.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 318,732 - 365,709 nt. (total: 46,978 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase oxidoreductase synthase
WH45_RS09615: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

WH45_RS09650: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

WH45_RS09700: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

WH45_RS09705: riboflavin biosynthesis protein RibD

smcogs
  SMCOG1240: riboflavin biosynthesis protein RibD

WH45_RS09715: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

WH45_RS09720: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

WH45_RS09725: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Hydrolases: dehalogenase hydrolase synthase
WH45_RS09620: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

WH45_RS09705: riboflavin biosynthesis protein RibD

smcogs
  SMCOG1240: riboflavin biosynthesis protein RibD

WH45_RS09710: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: dehydratase
WH45_RS09690: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
WH45_RS09655: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WH45_RS09685: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

WH45_RS09730: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001240.4 |  | 0.64 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.63 | NRPS | enniatin | Fusarium equiseti

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001240.4 |  | 0.64 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.63 | NRPS | enniatin | Fusarium equiseti

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.41 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.01 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.11 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.73 out of 28.19
Confidence: medium
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 21.65 out of 23.43
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.55 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.73 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.50 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.05 out of 32.93
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.50 out of 28.19
Confidence: medium
Additional weak hits (14):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.81 out of 27.55
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.19 out of 21.55
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.53 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.49 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.77 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.47 out of 21.55
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.02 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 28.95 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.99 out of 36.54
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.90 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.05 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.72 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.24 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 318731 - 365709:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS09655: Leu - X
Search NORINE for peptide: strict or relaxed
AMP-binding (315..698): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASVWEPFLLIGGEVNNYGPTENTVVTTS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1338..1735): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNNSFDGSTFDGLMLFGGEINVYGPTEATVCAAA
  Nearest Stachelhaus code(s):
    Val DGFLLGEVCK (79% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
BldD | Development and antibiotic global regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_KQ040792.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 490,797 - 519,426 nt. (total: 28,630 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
WH45_RS02245: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase
WH45_RS02220: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Lyases: cyclase
WH45_RS02195: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

WH45_RS02205: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.62 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001391.3 |  | 0.57 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002110.3 |  | 0.53 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002163.3 |  | 0.52 | other (other) | fusatin, fusatinic acid, 8-oxo-fusatin, 8-oxo-isopentenyladenine | Fusarium pseudograminearum CS3096
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.62 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001391.3 |  | 0.57 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002110.3 |  | 0.53 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002163.3 |  | 0.52 | other (other) | fusatin, fusatinic acid, 8-oxo-fusatin, 8-oxo-isopentenyladenine | Fusarium pseudograminearum CS3096
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for WH45_RS02195

WH45_RS23330
Leader:
MKEQWYDFAGNLEMELNEISLSELSGG
Core:
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
Core with dehydrations:
A E V Q G L Dha Q G N D G K V Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys F Cys

#### antiSMASH-DB 4.0 matches for WH45_RS23330

100.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
77.4%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A+V Q G+S Q G N D G K C T+T W E C +C P T H T C+C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
71.9%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E G+S Q G N D G K C T+T W E C +C P T H T C+C
2
A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
with 96 more sequence matches
Only the first 10 are displayed here.
71.9%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F
30
A E +G+S Q G N D G K C T L T W E C +C P T T C F
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F
30
71.9%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E G+S Q G N D G K C T+T W E C +C P T H T C+C
2
A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
71.1%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C F C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
71.0%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G C T+T W E C +C P T H T C+C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
69.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
E +G L S Q G N D G C T+T W E C G+C P T H T C+C
3
V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
69.7%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G C T+T W E C G+C P T H T C+C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.8%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E G+S+ N D G K C T L T W E C +C P T H T C+C
2
A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
68.4%
NC_023073.1 and 73 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
61.8%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
3
V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F
30
++ L S+G N G K V C T L T W E C G+C P+H T C F
6
I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33
59.4%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F
30
E + +S+G N D G K C T L T W E C +C P T T C+
1
V E T K K I S K G N D G K W C T L T W E C S I C P T K T C W
30

#### MIBiG 4.0 matches for WH45_RS23330

29.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
9
G N D G K V C T L T W E C
21
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
29.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
G N D G K V C T L T W E C
21
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T L T W E C
21
C T L+ E C
28
C T L S K E C
34
WH45_RS23705
Leader:
MKKQELIIAQVSEKELKELAGG
Core:
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
Core with dehydrations:
A E Dha Dhb P N G Dhb P A Dhb I I P V Dha L A I Cys P Dhb Dhb R Cys A Dha I V E Dha Cys N G

#### antiSMASH-DB 4.0 matches for WH45_RS23705

100.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
34
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
1
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
34
76.5%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
3
S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
34
S P G T P A T I I P V S L A I C P T T+C A S+V+ C N G
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N G
33
73.5%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
3
S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N
33
S P G T P A T I I P V S L A I C P T T+C A S+V+ C N
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N
32
with 65 more sequence matches
Only the first 10 are displayed here.
60.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
1
A E S T P N G T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34
+E P T P T+ I P+S L A C P T T+C A S I V C G
1
S E I Q P K W T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
58.8%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
I I P V S L A I C P T T R C A S I V E S C N G
34
I I P+S L A C P T T R C A S I V S C N G
8
I I P I S L A A C P T T R C A S I V S S C N G
30
58.8%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
5
P N G T P A T I I P V S L A I C P T T R C A S I V E S C N
33
P G T P I P+S A I C P T T+C A S I V C N
4
P Q G T P T V T I P I S A A I C P T T Q C A S I V R P C N
32
55.9%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
12
I I P V S L A I C P T T R C A S I V E S C N G
34
I I P+S L A C P T T R C A S I V C N G
8
I I P I S L A A C P T T R C A S I V S P C N G
30
52.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C
32
++T P+ P T I I P V S L A+C P T T C S C
2
D A T P D T H P T T I I P V S L A V C P T T T C R S F S S P C
32
47.1%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
A E S T P N G T P A T--I I P V S L A I C P T T R C A S
27
+ P T P A T I+ V S L I C P T T+C S
1
G D V N P E T T P A T P T I V A V S L G I C P T T K C T S
29
47.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
13
I P V S L A I C P T T R C A S I V E S C N G
34
I P+S L A C P T T+C A S I V C N
11
I P I S L A A C P T T Q C A S I V S P C N D
32
44.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
A E S T P N G T P A T I--I P V S L A I C P T T R C A S I V E S C N G
34
++ P P T I P+S C P T T+C A S+V E C N
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
44.1%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
13
I P V S L A I C P T T R C A S I V E S C N G
34
I P+S A C P T T+C A S+V+ C N G
13
I P I S A A A C P T T Q C A S V V K P C N G
34
42.1%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
A E S T P N G T P A T I--I P V S L A I C P T T R C A S I V E S C N G
34
++ P P T I P+S C P T T+C A S+V+ C N
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38

#### MIBiG 4.0 matches for WH45_RS23705

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I P V S L A I C P T T R C A S
27
+ V S A C P T T+C S
21
V G V S A A F C P T T K C T S
35
17.6%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
19
I C P T T R C A S
27
C P T T+C S
16
F C P T T K C T S
24
11.8%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
15
V S L A I C
20
V S L +C
5
V S L L V C
10
allorf_500346_500489
Leader:
MFTNTAPFA
Core:
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
Core with dehydrations:
Cys P H R I P Dha E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G

#### antiSMASH-DB 4.0 matches for allorf_500346_500489

100.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: allorf_500346_500489_lanthipeptide
Lanthipeptides: allorf_500346_500489_lanthipeptide
1
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
38
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
1
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
38

#### Lanthipeptide(s) for WH45_RS02205

WH45_RS23330
Leader:
MKEQWYDFAGNLEMELNEISLSELSGG
Core:
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
Core with dehydrations:
A E V Q G L Dha Q G N D G K V Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys F Cys

#### antiSMASH-DB 4.0 matches for WH45_RS23330

100.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
77.4%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A+V Q G+S Q G N D G K C T+T W E C +C P T H T C+C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
71.9%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E G+S Q G N D G K C T+T W E C +C P T H T C+C
2
A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
with 96 more sequence matches
Only the first 10 are displayed here.
71.9%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F
30
A E +G+S Q G N D G K C T L T W E C +C P T T C F
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F
30
71.9%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E G+S Q G N D G K C T+T W E C +C P T H T C+C
2
A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
71.1%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C F C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
71.0%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G C T+T W E C +C P T H T C+C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
69.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
E +G L S Q G N D G C T+T W E C G+C P T H T C+C
3
V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
69.7%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G C T+T W E C G+C P T H T C+C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.8%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E G+S+ N D G K C T L T W E C +C P T H T C+C
2
A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
68.4%
NC_023073.1 and 73 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
61.8%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
3
V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F
30
++ L S+G N G K V C T L T W E C G+C P+H T C F
6
I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33
59.4%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F
30
E + +S+G N D G K C T L T W E C +C P T T C+
1
V E T K K I S K G N D G K W C T L T W E C S I C P T K T C W
30

#### MIBiG 4.0 matches for WH45_RS23330

29.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
9
G N D G K V C T L T W E C
21
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
29.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
G N D G K V C T L T W E C
21
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T L T W E C
21
C T L+ E C
28
C T L S K E C
34
WH45_RS23705
Leader:
MKKQELIIAQVSEKELKELAGG
Core:
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
Core with dehydrations:
A E Dha Dhb P N G Dhb P A Dhb I I P V Dha L A I Cys P Dhb Dhb R Cys A Dha I V E Dha Cys N G

#### antiSMASH-DB 4.0 matches for WH45_RS23705

100.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
34
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
1
A E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
34
76.5%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
3
S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N G
34
S P G T P A T I I P V S L A I C P T T+C A S+V+ C N G
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N G
33
73.5%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
3
S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C N
33
S P G T P A T I I P V S L A I C P T T+C A S+V+ C N
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N
32
with 65 more sequence matches
Only the first 10 are displayed here.
60.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
1
A E S T P N G T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34
+E P T P T+ I P+S L A C P T T+C A S I V C G
1
S E I Q P K W T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
58.8%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
I I P V S L A I C P T T R C A S I V E S C N G
34
I I P+S L A C P T T R C A S I V S C N G
8
I I P I S L A A C P T T R C A S I V S S C N G
30
58.8%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
5
P N G T P A T I I P V S L A I C P T T R C A S I V E S C N
33
P G T P I P+S A I C P T T+C A S I V C N
4
P Q G T P T V T I P I S A A I C P T T Q C A S I V R P C N
32
55.9%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
12
I I P V S L A I C P T T R C A S I V E S C N G
34
I I P+S L A C P T T R C A S I V C N G
8
I I P I S L A A C P T T R C A S I V S P C N G
30
52.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E S T P N G T P A T I I P V S L A I C P T T R C A S I V E S C
32
++T P+ P T I I P V S L A+C P T T C S C
2
D A T P D T H P T T I I P V S L A V C P T T T C R S F S S P C
32
47.1%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
A E S T P N G T P A T--I I P V S L A I C P T T R C A S
27
+ P T P A T I+ V S L I C P T T+C S
1
G D V N P E T T P A T P T I V A V S L G I C P T T K C T S
29
47.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
13
I P V S L A I C P T T R C A S I V E S C N G
34
I P+S L A C P T T+C A S I V C N
11
I P I S L A A C P T T Q C A S I V S P C N D
32
44.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
A E S T P N G T P A T I--I P V S L A I C P T T R C A S I V E S C N G
34
++ P P T I P+S C P T T+C A S+V E C N
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
44.1%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
13
I P V S L A I C P T T R C A S I V E S C N G
34
I P+S A C P T T+C A S+V+ C N G
13
I P I S A A A C P T T Q C A S V V K P C N G
34
42.1%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
A E S T P N G T P A T I--I P V S L A I C P T T R C A S I V E S C N G
34
++ P P T I P+S C P T T+C A S+V+ C N
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38

#### MIBiG 4.0 matches for WH45_RS23705

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I P V S L A I C P T T R C A S
27
+ V S A C P T T+C S
21
V G V S A A F C P T T K C T S
35
17.6%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
19
I C P T T R C A S
27
C P T T+C S
16
F C P T T K C T S
24
11.8%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
15
V S L A I C
20
V S L +C
5
V S L L V C
10
allorf_500346_500489
Leader:
MFTNTAPFA
Core:
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
Core with dehydrations:
Cys P H R I P Dha E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G

#### antiSMASH-DB 4.0 matches for allorf_500346_500489

100.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: allorf_500346_500489_lanthipeptide
Lanthipeptides: allorf_500346_500489_lanthipeptide
1
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
38
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
1
C P H R I P S E N R K L K A L F R R Y L F A D G I A W I D Y D V L K G I Y G
38
allorf_514554_514673
Leader:
MLGRLAGEHALPLFLSGVDKGIHRNLASG
Core:
R S H S I T A E I C
Core with dehydrations:
R Dha H Dha I Dhb A E I Cys

#### antiSMASH-DB 4.0 matches for allorf_514554_514673

100.0%
NZ_KQ040792.1:
Lanthipeptides: allorf_514554_514673_lanthipeptide
1
R S H S I T A E I C
10
R S H S I T A E I C
1
R S H S I T A E I C
10

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.33 out of 21.55
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.38 out of 20.01
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.35 out of 28.19
Confidence: medium
Additional weak hits (3):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.15 out of 29.38
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.67 out of 23.43
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

WH45_RS23330 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 3209.4 Da
  Molecular weight: 3211.6 Da
  Number of bridges: 5
WH45_RS23705 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3210.6 Da
  Molecular weight: 3212.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3230.7 Da N = 1
    3248.7 Da N = 2
    3266.7 Da N = 3
    3284.7 Da N = 4
    3302.7 Da N = 5
    3320.8 Da N = 6
allorf_500346_500489 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 4475.4 Da
  Molecular weight: 4478.2 Da
  Number of bridges: 1
allorf_514554_514673 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1061.5 Da
  Molecular weight: 1062.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1080.2 Da N = 1
    1098.2 Da N = 2
WH45_RS23330 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 3209.4 Da
  Molecular weight: 3211.6 Da
  Number of bridges: 5
WH45_RS23705 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3210.6 Da
  Molecular weight: 3212.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3230.7 Da N = 1
    3248.7 Da N = 2
    3266.7 Da N = 3
    3284.7 Da N = 4
    3302.7 Da N = 5
    3320.8 Da N = 6
allorf_500346_500489 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 4475.4 Da
  Molecular weight: 4478.2 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
ArgR | Regulator of arginine biosynthesis genes
ZuR variant 1 | Zinc-responsive repressor

NZ_KQ040792.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 608,724 - 629,605 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
WH45_RS02685: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

WH45_RS02690: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

WH45_RS02715: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

WH45_RS02735: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acyltransferase kinase
WH45_RS02660: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

WH45_RS02705: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.61 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000640.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000664.5 |  | 0.43 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000642.3 |  | 0.43 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000635.3 |  | 0.42 | terpene | carotenoid | Paracoccus sp. N81106
BGC0000648.3 |  | 0.42 | terpene | carotenoid | Myxococcus xanthus
BGC0000646.5 |  | 0.42 | terpene | β-carotein | uncultured bacterium
BGC0000630.3 |  | 0.41 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000634.3 |  | 0.41 | terpene | carotenoid | Brevundimonas sp. SD212

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.61 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000640.3 |  | 0.45 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000664.5 |  | 0.43 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000642.3 |  | 0.43 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000635.3 |  | 0.42 | terpene | carotenoid | Paracoccus sp. N81106
BGC0000648.3 |  | 0.42 | terpene | carotenoid | Myxococcus xanthus
BGC0000646.5 |  | 0.42 | terpene | β-carotein | uncultured bacterium
BGC0000630.3 |  | 0.41 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000634.3 |  | 0.41 | terpene | carotenoid | Brevundimonas sp. SD212

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
WH45_RS02695: PT_phytoene_like
Domain 1 (10 - 278): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → diapophytoene
  FPP → squalene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.09 out of 29.72
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.15 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.95 out of 27.78
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.35 out of 18.57
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.35 out of 27.78
Confidence: medium
Additional weak hits (7):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.65 out of 27.55
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.18 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.79 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.18 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.67 out of 29.38
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis

NZ_LAQP01000004.1 - Region 1 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 25,578 nt. (total: 25,578 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: back translocase
WH45_RS12110: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: ligase synthase
WH45_RS12050: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WH45_RS12055: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WH45_RS12060: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001261.3 |  |  | 0.74 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001833.4 |  |  | 0.63 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001166.5 |  |  | 0.63 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  |  | 0.62 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.66 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001833.4 |  | 0.65 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  | 0.65 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.47 out of 26.06
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.36 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.57 out of 32.93
Confidence: medium
Additional weak hits (5):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.11 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.86 out of 30.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.16 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.36 out of 26.06
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 25578:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Orn) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 22277:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Orn) + (Val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS12050: Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (161..561): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ASWAFDVFIQDREFVSGADINSYGVTEVTVDNLY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (71% 8Å match)
  Stachelhaus code match:
    80% (moderate)

WH45_RS12055: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (505..915): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNTAFDAITFEGFVLVGGELNGYGPTESTTFALT
  Nearest Stachelhaus code(s):
    Val DALFLGGTFK (74% 8Å match)
    Ile DAFFLGVTFK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_LAQP01000004.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 363,162 - 384,088 nt. (total: 20,927 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
WH45_RS13675: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
WH45_RS13715: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

WH45_RS13720: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001725.3 |  | 0.40 | other (other) | oxetanocin A | Bacillus megaterium
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001594.3 |  | 0.37 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000635.3 |  | 0.37 | terpene | carotenoid | Paracoccus sp. N81106

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001725.3 |  | 0.40 | other (other) | oxetanocin A | Bacillus megaterium
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001594.3 |  | 0.37 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000635.3 |  | 0.37 | terpene | carotenoid | Paracoccus sp. N81106

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
WH45_RS13715: PT_FPPS_like
Domain 1 (44 - 308): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.58 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.68 out of 24.78
Confidence: medium
Additional weak hits (8):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.84 out of 39.62
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.08 out of 28.14
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.20 out of 30.22
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.97 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.44 out of 36.54
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.75 out of 32.93
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.12 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.90 out of 29.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_KQ040793.1 - Region 1 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 348,569 - 368,811 nt. (total: 20,243 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Translocases: transporter
WH45_RS04580: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001779.5 |  | 0.41 | ribosomal | siamycin | Streptomyces nodosus
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.40 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.39 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000498.5 |  | 0.39 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000521.3 |  | 0.39 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000561.5 |  | 0.39 | ribosomal | thermophilin 1277 | Streptococcus thermophilus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001779.5 |  | 0.41 | ribosomal | siamycin | Streptomyces nodosus
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.40 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.39 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000498.5 |  | 0.39 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000521.3 |  | 0.39 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000561.5 |  | 0.39 | ribosomal | thermophilin 1277 | Streptococcus thermophilus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19
Confidence: medium
Additional weak hits (7):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.54 out of 20.01
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.59 out of 30.97
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.21 out of 25.88
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.80 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.18 out of 26.06
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.23 out of 20.01
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_KQ040793.1 - Region 2 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 386,456 - 411,239 nt. (total: 24,784 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
WH45_RS04705: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

WH45_RS04745: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Hydrolases: deacetylase hydrolase
WH45_RS04690: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

WH45_RS04735: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.67 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.52 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0002312.2 |  | 0.52 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0002298.2 |  | 0.51 | ribosomal | lassomycin-like peptide | Sanguibacter keddieii DSM 10542
BGC0000571.3 |  | 0.51 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0002825.2 |  | 0.49 | ribosomal | nocapeptin A | Nocardia terpenica IFM 0406
BGC0002322.3 |  | 0.48 | ribosomal | citrocin | Citrobacter pasteurii
BGC0002064.2 |  | 0.47 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10
BGC0001496.3 |  | 0.47 | ribosomal | actinokineosin | Actinokineospora spheciospongiae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.67 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.52 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0002312.2 |  | 0.52 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0002298.2 |  | 0.51 | ribosomal | lassomycin-like peptide | Sanguibacter keddieii DSM 10542
BGC0000571.3 |  | 0.51 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0002825.2 |  | 0.49 | ribosomal | nocapeptin A | Nocardia terpenica IFM 0406
BGC0002322.3 |  | 0.48 | ribosomal | citrocin | Citrobacter pasteurii
BGC0002064.2 |  | 0.47 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10
BGC0001496.3 |  | 0.47 | ribosomal | actinokineosin | Actinokineospora spheciospongiae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for WH45_RS23335

WH45_RS23335
Leader:
MNNEKMQWQAPALEVLEMNETAA
Full core:
G K G W K A I D W V T Y D D A D L Y N P G S
Putative macrolactam:
G K G W K A I D

#### antiSMASH-DB 4.0 matches for WH45_RS23335

100.0%
NZ_CP013023.1 and 2 others:
NZ_KQ040793.1 Lassopeptides: WH45_RS23335_lassopeptide NZ_KQ040798.1 Lassopeptides: WH46_RS23985_lassopeptide
Lassopeptides: AR543_RS24050_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P G S
22
G K G W K A I D W V T Y D D A D L Y N P G S
1
G K G W K A I D W V T Y D D A D L Y N P G S
22
95.5%
NZ_CP013023.1 and 4 others:
NZ_CP013023.1 Lassopeptides: AR543_RS24035_lassopeptide NZ_KQ040793.1 Lassopeptides: WH45_RS23345_lassopeptide NZ_KQ040798.1 Lassopeptides: WH46_RS24000_lassopeptide NZ_KQ040798.1 Lassopeptides: WH46_RS23995_lassopeptide
Lassopeptides: AR543_RS24040_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P G S
22
G K G W K I D W V T Y D D A D L Y N P G S
1
G K G W K V I D W V T Y D D A D L Y N P G S
22
90.9%
NZ_BMMB01000001.1:
Lassopeptides: IEX62_RS00125_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W K A I D W V T Y D D A D L Y N P
1
G K G W K A I D W V T Y D D A D L Y N P
20
with 29 more sequence matches
Only the first 10 are displayed here.
90.9%
NZ_KQ040793.1:
Lassopeptides: WH45_RS23350_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P G S
22
G K G W+ I D W V T Y D D A D L Y N P G S
1
G K G W R V I D W V T Y D D A D L Y N P G S
22
81.8%
NZ_BMMB01000001.1 and 3 others:
NZ_CP013023.1 Lassopeptides: AR543_RS24045_lassopeptide NZ_KQ040793.1 Lassopeptides: WH45_RS23340_lassopeptide NZ_KQ040798.1 Lassopeptides: WH46_RS23990_lassopeptide
Lassopeptides: IEX62_RS00120_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W+ I D W V T Y D D A D L Y N P
1
G K G W R V I D W V T Y D D A D L Y N P
20
77.3%
NZ_AGFX01000048.1 and 1 other:
NZ_JH601049.1 Lassopeptides: WG8_RS27060_lassopeptide
Lassopeptides: KQI_RS28660_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P G S
22
G K G W K I D W V+ D A D L Y N P S
1
G K G W K Q I D W V S D H D A D L Y N P P S
22
72.7%
NC_014622.2 and 26 others:
NC_016641.1 Lassopeptides: HPL003_RS28495_lassopeptide NC_017542.1 Lassopeptides: PPM_RS29155_lassopeptide NZ_CP006872.1 Lassopeptides: PPSQR21_RS25845_lassopeptide NZ_CP020028.1 Lassopeptides: B4V02_RS25945_lassopeptide NZ_CP023711.1 Lassopeptides: CPY53_RS20730_lassopeptide NZ_CP025696.1 Lassopeptides: C0638_RS25110_lassopeptide NZ_CP025957.1 Lassopeptides: C1A50_RS25040_lassopeptide NZ_CP029370.1 Lassopeptides: DI243_RS05990_lassopeptide NZ_CP034141.1 Lassopeptides: EGM68_RS06425_lassopeptide NZ_CP040829.1 Lassopeptides: FGY93_RS02005_lassopeptide NZ_CP041731.1 Lassopeptides: FOA15_RS11830_lassopeptide NZ_CP042272.1 Lassopeptides: FQU75_RS22710_lassopeptide NZ_CP049598.1 Lassopeptides: G7L40_RS02540_lassopeptide NZ_CP084033.1 Lassopeptides: LAZ93_RS06040_lassopeptide NZ_CP085682.1 Lassopeptides: LJR53_RS05900_lassopeptide NZ_CP086373.1 Lassopeptides: LMH85_RS06275_lassopeptide NZ_CP092779.1 Lassopeptides: MJ749_RS05940_lassopeptide NZ_CP097766.1 Lassopeptides: MF620_RS06000_lassopeptide NZ_CP102865.1 Lassopeptides: NWS42_RS19270_lassopeptide NZ_FNYX01000001.1 Lassopeptides: BMY87_RS25010_lassopeptide NZ_JAOYTP010000002.1 Lassopeptides: OIU26_RS08460_lassopeptide NZ_JWJJ01000002.1 Lassopeptides: U707_RS25590_lassopeptide NZ_LNZF01000001.1 Lassopeptides: AVK83_RS26330_lassopeptide NZ_PNXP01000013.1 Lassopeptides: C1I59_RS05635_lassopeptide NZ_PNXQ01000012.1 Lassopeptides: C1I60_RS12180_lassopeptide NZ_POVT01000017.1 Lassopeptides: C1T20_RS25045_lassopeptide
Lassopeptides: PPSC2_RS58945_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W K I D W V+ D A D L Y N P
1
G K G W K Q I D W V S D H D A D L Y N P
20
72.7%
NZ_CP045298.1:
Lassopeptides: GCU48_RS16790_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W K I D W V+ D A D L Y N P
1
G K G W K N I D W V S D F D A D L Y N P
20
68.2%
NC_014483.2 and 10 others:
NC_023037.2 Lassopeptides: X809_RS27480_lassopeptide NZ_CP011420.1 Lassopeptides: VK72_RS27415_lassopeptide NZ_CP017967.2 Lassopeptides: PPYC1_RS06115_lassopeptide NZ_CP017968.3 Lassopeptides: PPYC2_RS06795_lassopeptide NZ_CP073682.1 Lassopeptides: KAI36_RS06145_lassopeptide NZ_CP073683.1 Lassopeptides: KAI37_RS05910_lassopeptide NZ_CP109848.1 Lassopeptides: OF859_RS24335_lassopeptide NZ_CP113973.1 Lassopeptides: OYT09_RS06050_lassopeptide NZ_FOYG01000001.1 Lassopeptides: BM358_RS26180_lassopeptide NZ_PTJM01000055.1 Lassopeptides: C5G87_RS12815_lassopeptide
Lassopeptides: PPE_RS25060_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W K I D W V+ D A D L+N P
1
G K G W K Q I D W V S D H D A D L H N P
20
68.2%
NZ_CP013203.1:
Lassopeptides: ASL14_RS05780_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W K I D W V+ D A D L N P
1
G K G W K E I D W V S D H D A D L V N P
20
68.2%
NZ_CP117876.1:
Lassopeptides: PQ460_RS19030_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G G W K I D W V+ D A D L Y N P
1
G I G W K Q I D W V S E Q D A D L Y N P
20
63.6%
NZ_CAKMMP010000007.1:
Lassopeptides: L6H98_RS13765_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P G S
22
G G W+ I D W++ D A D L Y N P S
1
G I G W R Q I D W I S D H D A D L Y N P V S
22
63.6%
NZ_CP015423.1 and 9 others:
NZ_CP061172.1 Lassopeptides: IAQ67_RS05910_lassopeptide NZ_CP071875.1 Lassopeptides: J4I02_RS06550_lassopeptide NZ_CP092831.1 Lassopeptides: MLD56_RS06365_lassopeptide NZ_JAAMNR010000001.1 Lassopeptides: G9G54_RS05075_lassopeptide NZ_JAFJXZ010000012.1 Lassopeptides: JYU28_RS05205_lassopeptide NZ_JAKVDC010000001.1 Lassopeptides: MKN04_RS01225_lassopeptide NZ_JANAVI010000007.1 Lassopeptides: NLX74_RS16260_lassopeptide NZ_JANAVN010000010.1 Lassopeptides: NLX78_RS16305_lassopeptide NZ_POVS01000014.1 Lassopeptides: C1T21_RS27040_lassopeptide
Lassopeptides: AOU00_RS26345_lassopeptide
1
G K G W K A I D W V T Y D D A D L Y N P
20
G K G W+ I D W V+ D A D+Y N P
1
G K G W R Q I D W V S D H D A D I Y N P
20

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.28 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.41 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.02 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.66 out of 23.79
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78
Confidence: medium
Additional weak hits (19):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.40 out of 21.55
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.45 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.12 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.69 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.42 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.68 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.08 out of 27.78
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.57 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.02 out of 30.22
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.17 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.48 out of 33.14
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.52 out of 30.11
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.35 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.03 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.08 out of 26.12
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 35.63
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

WH45_RS23335 - Class II
  Cleavage pHMM score: -13.10
  RODEO score: 17
  Monoisotopic mass: 2452.1 Da
  Molecular weight: 2453.6 Da
  Number of bridges: 0

RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (386455...411239)
WH45_RS04725
  RRE type: Stand_Alone_Lasso_RRE
  Location: 14 - 94
  Score: 93.9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_KQ040794.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 131,234 - 193,787 nt. (total: 62,554 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase oxidoreductase
WH45_RS05660: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

WH45_RS05685: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

WH45_RS05695: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

WH45_RS05700: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: kinase phosphotransferase
WH45_RS05635: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

WH45_RS05745: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase
WH45_RS05650: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

WH45_RS05720: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Lyases: dehydratase
WH45_RS05675: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
WH45_RS05690: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WH45_RS05705: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

WH45_RS05715: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001152.5 |  | 0.80 | NRPS, PKS | fusaricidin B | Paenibacillus polymyxa
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.67 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001152.5 |  | 0.80 | NRPS, PKS | fusaricidin B | Paenibacillus polymyxa
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.67 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.10 out of 23.79
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.13 out of 18.57
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.38 out of 25.88
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.59 out of 18.57
Confidence: medium
Additional weak hits (15):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.95 out of 29.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.04 out of 29.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.17 out of 39.62
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.75 out of 21.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.56 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.19 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.79 out of 30.97
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.26 out of 36.54
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.74 out of 24.78
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.50 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.72 out of 35.63
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 131233 - 193787:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Thr - D-Val - D-Thr - D-Asn - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS05690: X
AMP-binding (12..386): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    SAMVHFYGISLSDACVGGSLNGYGLSELGNVTLG
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

WH45_RS05715: Thr - Val - Thr - Asn - X
Search NORINE for peptide: strict or relaxed
AMP-binding (462..860): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1502..1895): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNTGFDASTFEGWLIVGGDINGYGPTENTTFSTT
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3661..4059): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (5174..5569): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTYTSTKLIVGGEYNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (6686..7087): X
nrpys: Ala, D-Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LQLTFDFSIPESNLFACGEENIYGPTEATVYATR
  Nearest Stachelhaus code(s):
    Ala or D-Ala DFPNFCIVYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis

NZ_KQ040794.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 398,045 - 424,750 nt. (total: 26,706 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: electron transfer
WH45_RS06790: flavodoxin

smcogs
  SMCOG1134: flavodoxin

Transferases: methyltransferase
WH45_RS06780: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Lyases: cyclase
WH45_RS06785: diguanylate cyclase

smcogs
  SMCOG1025: diguanylate cyclase

Ligases: ligase
WH45_RS06825: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WH45_RS06830: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0000357.5 |  | 0.67 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001240.4 |  | 0.65 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.65 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001133.4 |  | 0.64 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0000357.5 |  | 0.67 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001240.4 |  | 0.65 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.65 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001133.4 |  | 0.64 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.40 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.67 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.28 out of 27.78
Confidence: medium
Additional weak hits (3):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.12 out of 36.54
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.64 out of 28.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 398044 - 424750:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Phe) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS06825: Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (473..860): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAQAFDASVWEMTFIVAGEWNAYGPSETTVCATV
  Nearest Stachelhaus code(s):
    Phe DAWTIAAVCK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

WH45_RS06830: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (17..416): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSSFDAITFEGFILFGGESNIYGPTECTTFSLS
  Nearest Stachelhaus code(s):
    Ile DAFFLGITFK (71% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems

NZ_LAQP01000013.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 48,869 - 92,573 nt. (total: 43,705 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase methyltransferase
WH45_RS15275: methyltransferase

smcogs
  SMCOG1089: methyltransferase

WH45_RS15310: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: peptidase protease
WH45_RS15165: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

WH45_RS15315: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

WH45_RS22915: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Ligases: ligase
WH45_RS15230: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002164.2 |  | 0.62 | NRPS | peramine | Epichloe festucae
BGC0002276.2 |  | 0.62 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001758.4 |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.59 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001166.5 |  | 0.59 | NRPS | HC-toxin | Alternaria jesenskae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002164.2 |  | 0.62 | NRPS | peramine | Epichloe festucae
BGC0002276.2 |  | 0.62 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001758.4 |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.59 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001166.5 |  | 0.59 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.29 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 27.45 out of 33.14
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.95 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.75 out of 28.19
Confidence: medium
Additional weak hits (24):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.00 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.15 out of 29.38
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.46 out of 29.25
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.72 out of 25.88
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.99 out of 27.55
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.83 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.56 out of 36.54
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.67 out of 24.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.61 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.97 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.82 out of 28.14
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.36 out of 32.93
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.95 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.83 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.22 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.12 out of 33.14
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.44 out of 32.93
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.27 out of 29.65
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.84 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 48868 - 92573:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Phe)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS15230: Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (224..636): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LILAFDGSVWDATLAVAGEVNAYGPTECTVCATM
  Nearest Stachelhaus code(s):
    Phe DAWTVAAVCK (76% 8Å match)
  Stachelhaus code match:
    80% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor
ZuR variant 2 | Zinc-responsive repressor

NZ_LAQP01000015.1 - Region 1 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 32,153 - 84,430 nt. (total: 52,278 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
WH45_RS17520: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

WH45_RS17525: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

WH45_RS17585: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase
WH45_RS17570: isochorismatase

smcogs
  SMCOG1027: isochorismatase

WH45_RS17665: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Isomerases: isomerase
WH45_RS17580: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
WH45_RS17565: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WH45_RS17575: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000401.5 |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0000309.5 |  |  | 1.02 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  |  | 1.01 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000343.5 |  |  | 0.85 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0002075.3 |  |  | 0.85 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002695.2 |  |  | 0.74 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0000309.5 |  | 0.79 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  | 0.79 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002695.2 |  | 0.70 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.37 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.03 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.27 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.34 out of 27.55
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.34 out of 27.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.41 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.36 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.20 out of 29.38
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.29 out of 29.25
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.04 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.70 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.61 out of 23.79
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.64 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (22):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.58 out of 28.14
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.70 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.49 out of 36.54
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.90 out of 29.25
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.01 out of 32.93
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.05 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.62 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.78 out of 21.55
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.04 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.95 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.66 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.99 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.60 out of 28.14
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.41 out of 29.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.90 out of 36.54
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.09 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.03 out of 36.54
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 28.19
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.33 out of 20.01
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 32152 - 84430:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ala - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS17565: Ala - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (465..870): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGMTFDISVLELQAITGGEHNQYGPTETTIYSTA
  Nearest Stachelhaus code(s):
    Ala DILQIGQIYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1536..1952): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQIFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

WH45_RS17575: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (32..437): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SASLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (97% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_LAQP01000018.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 49,920 - 72,301 nt. (total: 22,382 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: dehydratase
WH45_RS20255: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase
WH45_RS20240: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001456.3 |  | 0.33 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.31 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3 |  | 0.29 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001647.3 |  | 0.26 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001657.4 |  | 0.23 | NRPS | lysocin | Lysobacter sp. RH2180-5
BGC0000220.4 |  | 0.23 | PKS | enterocin | Streptomyces maritimus
BGC0000692.5 |  | 0.21 | saccharide | apramycin | Streptoalloteichus hindustanus
BGC0000376.5 |  | 0.19 | NRPS | JBIR-34, JBIR-35 | Streptomyces sp. Sp080513GE-23

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001456.3 |  | 0.33 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.31 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3 |  | 0.29 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001647.3 |  | 0.26 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001657.4 |  | 0.23 | NRPS | lysocin | Lysobacter sp. RH2180-5
BGC0000220.4 |  | 0.23 | PKS | enterocin | Streptomyces maritimus
BGC0000692.5 |  | 0.21 | saccharide | apramycin | Streptoalloteichus hindustanus
BGC0000376.5 |  | 0.19 | NRPS | JBIR-34, JBIR-35 | Streptomyces sp. Sp080513GE-23

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
WH45_RS20240: PT_FPPS_like
Domain 1 (535 - 757): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
Additional weak hits (12):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.53 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.95 out of 36.54
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.65 out of 21.55
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.56 out of 36.53
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.83 out of 26.06
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.07 out of 20.01
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.55 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.93 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.93 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.13 out of 35.63
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.44 out of 36.53
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence

NZ_KQ040797.1 - Region 1 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 5,905 nt. (total: 5,905 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
WH45_RS08240: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WH45_RS08245: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001249.5 |  |  | 0.82 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  |  | 0.73 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  | 0.72 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  |  | 0.71 | NRPS | enniatin | Fusarium equiseti
BGC0002135.2 |  |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  |  | 0.66 | NRPS | peramine | Epichloe festucae
BGC0000307.4 |  |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.73 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae
BGC0000307.4 |  | 0.66 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 5905:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WH45_RS08240: X
AMP-binding (163..561): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YFMAVDGFFRDALSMCSGEINLYGPTETTLTTTY
  Nearest Stachelhaus code(s):
    Asp DPRHVSLLAK (53% 8Å match)
  Stachelhaus code match:
    60% (weak)

WH45_RS08245: X
AMP-binding (472..869): X
nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNTMFDISTFEGAILIGGELNSYGPSENTAITLN
  Nearest Stachelhaus code(s):
    Leu DIFALGGVAK (50% 8Å match)
    Trp DIFALGDFRK (47% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor