LOCUS       NZ_CP010954            24627 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Sphingobium sp. YBL2 chromosome, complete genome.
ACCESSION   NZ_CP010954
VERSION     NZ_CP010954.1
KEYWORDS    RefSeq.
SOURCE      Sphingobium sp. YBL2
  ORGANISM  Sphingobium sp. YBL2
            Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
            Sphingomonadaceae; Sphingobium.
REFERENCE   1  (bases 1 to 4766421)
  AUTHORS   Yan,X.
  TITLE     The analysis of one genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4766421)
  AUTHORS   Yan,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-FEB-2015) College of Life Sciences, Nanjing
            Agriculture University, Weigang Street #1, Nanjing, Jiangsu 210000,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2014
            Assembly Method                   :: Celera Assembler v. 8.0
            Assembly Name                     :: YBL2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina MiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000943805.1-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 04:34:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,219
            CDSs (total)                      :: 5,153
            Genes (coding)                    :: 5,086
            CDSs (with protein)               :: 5,086
            Genes (RNA)                       :: 66
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 25 of 67
            Pseudo Genes (incomplete)         :: 53 of 67
            Pseudo Genes (internal stop)      :: 4 of 67
            Pseudo Genes (multiple problems)  :: 12 of 67
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 431994
            Orig. end                         :: 456621
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP010954.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from yanxin@njau.edu.cn.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24627
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="hserlactone"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="Autoind_synth"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..24627
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="Autoind_synth"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="neighbouring"
                     /product="hserlactone"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20387
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20387
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10387](+)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10387
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
     misc_feature    507..523
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.18"
                     /tool="antismash"
     misc_feature    897..912
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.81"
                     /tool="antismash"
     misc_feature    complement(1078..1090)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     cand_cluster    2220..24627
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    2220..24627
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12219:14627](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12220..14627
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="2"
     misc_feature    complement(2283..2297)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.72"
                     /tool="antismash"
     gene            3374..3648
                     /locus_tag="TZ53_RS02110"
                     /old_locus_tag="TZ53_02105"
                     /pseudo=""
     CDS             3374..3648
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017182407.1"
                     /locus_tag="TZ53_RS02110"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02105"
                     /product="HU family DNA-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNDAGLADALAADHGISKADARNMGMPSSPPSSILPARVTKCP"
     gene            complement(4044..4673)
                     /locus_tag="TZ53_RS02115"
                     /old_locus_tag="TZ53_02110"
     CDS             complement(4044..4673)
                     /EC_number="4.2.2.n1"
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007682978.1"
                     /locus_tag="TZ53_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02110"
                     /product="lytic transglycosylase domain-containing protein"
                     /protein_id="WP_044660274.1"
                     /transl_table=11
                     /translation="MAGLTRCLRSIATGLILWATPLHADPVADWAGEIAEASARFGIDR
                     LWVEAVMRAESGGRTVWQGKPITSSAGAMGLMQLMPGTWADMRRLHGLGQNPHNPHDNI
                     LAGTAYLAAMNQRFGYPGLFGAYHAGPERYRQFLIKGRPLPPETRAYMMTLASLIGPYP
                     TALPPPSPVANPPPLFIYLAGEPVPEKAEAPGEGRANSDPLFAVRR"
     gene            complement(4661..5233)
                     /locus_tag="TZ53_RS02120"
                     /old_locus_tag="TZ53_02115"
     CDS             complement(4661..5233)
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006465 - signal peptide processing
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041106.1"
                     /locus_tag="TZ53_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02115"
                     /product="S26 family signal peptidase"
                     /protein_id="WP_044660275.1"
                     /transl_table=11
                     /translation="MSRPRDLPLFAWGEALRAARARRRRLRRHAIWIGLGAFALGATIA
                     FPPSPRLVWNATASAPVGFYLVYPGARLARGDMVLARAPYPARLLAARRHYLPMNLPLV
                     KRVIGVPGDIVCARGDGVMLDGKLVARRLLHDSMGRTLPWWEGCEGLRPGRYFLLMDKV
                     PASFDGRYFGPVGEADIIGKASPLWLG"
     gene            complement(5230..5487)
                     /locus_tag="TZ53_RS02125"
                     /old_locus_tag="TZ53_02120"
     CDS             complement(5230..5487)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041107.1"
                     /locus_tag="TZ53_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02120"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_044660276.1"
                     /transl_table=11
                     /translation="MEDHAKERPGAQLRDLAERARVARNTCPYLTAKQAAFHLGIAANT
                     LKRLRHQGRGPLCRMHGGSWRYHVDDLDAWSAAHRSGEGA"
     gene            complement(5663..5983)
                     /locus_tag="TZ53_RS02130"
                     /old_locus_tag="TZ53_02125"
     CDS             complement(5663..5983)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008996391.1"
                     /locus_tag="TZ53_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02125"
                     /product="DUF736 domain-containing protein"
                     /protein_id="WP_013041108.1"
                     /transl_table=11
                     /translation="MAAIGYVTRNGNGFKGQLRTLSIRTDVEIIPNSHKNGSTQPDYRV
                     LASGVEIGAGWIRISETSGKDYVSLSLAAPEFGPRRLYANLGRAAGQDDEDAFAIIWNP
                     AD"
     gene            complement(6506..7159)
                     /locus_tag="TZ53_RS25500"
     CDS             complement(6506..7159)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021581.4"
                     /locus_tag="TZ53_RS25500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2285 domain-containing protein"
                     /protein_id="WP_172668293.1"
                     /transl_table=11
                     /translation="MRRRAASPEVPWTRRHGGFTFAEHPDLPAPEARIIWRADIDPATL
                     PVVIANHSAPVEERIELGQLLPWLRIATDTMGREHAVLSDGLRHLRIDIMAGSLTHTRG
                     AVLLHYEIWGSQMAARRLRTLERFLDLVRTGRFRAPLYPADPVIGRGLALLRVHDARAS
                     GASHREIGKALFGALAVEAGWEGRTDHVRQRVRRMVKSARAMAQGGYRLLMRPK"
     misc_feature    7529..7542
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            7532..7939
                     /locus_tag="TZ53_RS02145"
                     /old_locus_tag="TZ53_02140"
     CDS             7532..7939
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015437.4"
                     /locus_tag="TZ53_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02140"
                     /product="autoinducer binding domain-containing protein"
                     /protein_id="WP_238320101.1"
                     /transl_table=11
                     /translation="MSMHQEAMHFLQCINQVRTRDDMGSVMRVIAEQLGFQYFALTQHV
                     DVVAAGSGVIHIHNYPDRWADFYAANALGITDPVHRACHMTSWGFRWTQMPALIPLTSG
                     DHRHLARGRQAGIGDGFTIPSNIGLASALVV"
     gene            8075..9286
                     /locus_tag="TZ53_RS02150"
                     /old_locus_tag="TZ53_02145"
     CDS             8075..9286
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006954973.1"
                     /locus_tag="TZ53_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02145"
                     /product="IS256 family transposase"
                     /protein_id="WP_011950834.1"
                     /transl_table=11
                     /translation="MTDDRLPLAELMAKTGDGDFLRTIAESVLQIIMEADVDGLVGASR
                     HERSGDRTTWRNGYRDRSLDTRLGTLNLRIPKLRTGAYFPGFLEPRKTVEKALVAVIQE
                     AWIAGVSTRRVDELVQAMGMTGISKSSVSKLCKDIDERVHAFLKRPLTGDWPYLWLDAT
                     YLKVREGGRIVSVAAIIAVAVNTEGKREIVGLHIGPSEAEPFWSSFLKDLARRGLTGVK
                     LVISDAHEGLKAAITRVLSATWQRCRVHFMRNALAYVPKGQNTVVAAAIRQVFLQPDHA
                     AATQVWRQVADQLRTRWPKLGACMDDAEHDVLAYMTFPEQHRVKLHSTNPLERLNKEVK
                     RRADVVGIFPNEDSIIRLVGAVLLEQNDEYQLQHRYMQIEGMAALATPMIEEAQPLQIT
                     PKAA"
     gene            9289..9732
                     /locus_tag="TZ53_RS02155"
                     /old_locus_tag="TZ53_02150"
     CDS             9289..9732
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="TZ53_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02150"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_238320102.1"
                     /transl_table=11
                     /translation="MQPAGHTQFYTTLTDATNIGGQPPGSCTFANAGDRPLREDRLLLA
                     QLLGNYAFDAARRLWSMPRQAMTAPLITDRQRDCVQWAARGKSDWETSQILDISRETVT
                     SHIKEACARYQVNKRILLVGRTLGDGTLTISDIGGWSHPHFWE"
     misc_feature    complement(9791..9805)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            10001..10387
                     /locus_tag="TZ53_RS27815"
                     /old_locus_tag="TZ53_02155"
     CDS             10001..10387
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012967.4"
                     /locus_tag="TZ53_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02155"
                     /product="acyl-homoserine-lactone synthase"
                     /protein_id="WP_337589254.1"
                     /sec_met_domain="Autoind_synth (E-value: 5.9e-08, bitscore:
                     30.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTQRPHILDSFYARLCDAPPPRGGDIFEITRFCLDRNLRAAERR
                     VVRNRLVTAIAEHALENRISRYVAIAEMNWFQQILAFGWQCRPLGAPQWHEGSLLVALE
                     IEMGADTLDRLAEAGIYDQAPMAA"
     gene            10404..11270
                     /locus_tag="TZ53_RS02165"
                     /old_locus_tag="TZ53_02160"
     CDS             10404..11270
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007679471.1"
                     /locus_tag="TZ53_RS02165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02160"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_044662799.1"
                     /sec_met_domain="PhyH (E-value: 2.1e-20, bitscore: 71.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPLPTSASRLIEQLFDQGWSVLPHALPEGVIAALDADLSPSFA
                     ETPFCQGPFYGETTKRFGRLLTRSSHAEALVRHPLITRIARQILAPWCDCIQLNVGQAI
                     AIHPGAPAQAPHRDQDMWQAPKGEIEYLVNIIWPLTPFTADNGATLVWPRSHGAQALLP
                     GPVTDPIAVGMEPGSALILLGSTLHGAGANRTAAVRRAIVTGYSLGWLKPYENPWLAYP
                     PAVARRFSPELAALAGYRQHRPNLGNFEGQCPSVLLTGAPDRPLAAIDALRPDQQDMVA
                     AFAARQS"
     gene            11331..11882
                     /locus_tag="TZ53_RS02170"
                     /old_locus_tag="TZ53_02165"
     CDS             11331..11882
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012610.4"
                     /locus_tag="TZ53_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02165"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_044660278.1"
                     /transl_table=11
                     /translation="MERGYRPGSRLDPAELSAILASSTTPIREALNHLAGEGLVEARSG
                     GGFLVPLIDEPGLKDLYAWSGDIVQLALRSARLSLLRAIELDPDFASGADRAAHLLHRI
                     ASASSNREHGEAMERTNARLHVARIGEEDILGDTGEELQALAHSARAGDIGLLRRTSST
                     YHLRRQRAAAKLLRGIYRDE"
     misc_feature    11917..11931
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.85"
                     /tool="antismash"
     gene            12048..12167
                     /locus_tag="TZ53_RS26595"
     CDS             12048..12167
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017181796.1"
                     /locus_tag="TZ53_RS26595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="benenodin family lasso peptide"
                     /protein_id="WP_126516753.1"
                     /transl_table=11
                     /translation="MERDNDVIELGAVSVETKGPGGITGDVGLGENNFGLSDD"
     CDS_motif       12048..12101
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MERDNDVIELGAVSVETK"
                     /locus_tag="TZ53_RS26595_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       12102..12155
                     /prepeptide="core"
                     /locus_tag="TZ53_RS26595_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="10.20"
                     /molecular_weight="1973.0"
                     /monoisotopic_mass="1971.9"
                     /core_sequence="GPGGITGDVGLGENNFG"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MERDNDVIELGAVSVETK"
                     /leader_location="[12047:12101](+)"
                     /tail_sequence="LSDD"
                     /tail_location="[12155:12167](+)"
     CDS_motif       12156..12167
                     /locus_tag="TZ53_RS26595_lassopeptide"
                     /note="tail peptide"
                     /note="lassopeptide"
                     /prepeptide="tail"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     gene            12220..12876
                     /locus_tag="TZ53_RS25505"
     CDS             12220..12876
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="TZ53_RS25505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_172668294.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 2.8e-14,
                     bitscore: 51.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF13471 (E-value: 7.3e-22, bitscore: 75.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGYTLRDGLSFCRTEGHVIFLDLHADRYFGLRPALDQAFRSLID
                     ANHIDARQCDALLEAGIIIRSPVGIRPAPCPRSHASEARLPIAKPRLSPAYLASALTRR
                     FWWRARLRQLPFSRNIRLIEQRKYGVAPRTAPTDRLAHIDQAYRRAAMIVSARDQCLPT
                     ALSLASWLIALGIRPDLVLGVKLNPFQAHSWVEVDGMVVADDPDQVRPFCPIRII"
     aSDomain        12226..12414
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_TZ53_RS25505_Lasso_Fused_RRE.1"
                     /evalue="1.70E-16"
                     /identifier="RREFam003.1"
                     /label="TZ53_RS25505"
                     /locus_tag="TZ53_RS25505"
                     /protein_end="65"
                     /protein_start="2"
                     /score="51.0"
                     /tool="antismash"
                     /translation="GYTLRDGLSFCRTEGHVIFLDLHADRYFGLRPALDQAFRSLIDAN
                     HIDARQCDALLEAGIIIR"
     gene            12876..14627
                     /locus_tag="TZ53_RS02180"
                     /old_locus_tag="TZ53_02175"
     CDS             12876..14627
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041125.1"
                     /locus_tag="TZ53_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02175"
                     /product="asparagine synthetase B family protein"
                     /protein_id="WP_044660279.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.1e-25, bitscore:
                     87.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERFVAIFAPKPERSPIAPPIRSAISRAEALSVMIDGDDMLVASG
                     GGQVRHLGDDIGMVIGPIFATGKSDPATPPSDVASSGDPSDLHRFSQDYWGNFVAILRD
                     RAAGFHVLRSAFGRLPCFHAVQGDQLILASDMALLSLGGWKSRGVEWSAILRRLALKDI
                     PSPSTCLIGVQELRGGSRLHLTPEGLSVTQTWNPWDRAGRRHWIDDRDEAARMIRRAVS
                     TATRASIMGAKRALLMLSGGIDSSVLAAALGTHGCPFTCFNLASRGAIGDERHYARMVA
                     SHLGAPTIEAQWDAGMVDVSRSHTQDQPNPLARSFMQGTSRLLHEAVGASGADLTIDGG
                     GGDNVFFSLRSIAPVTDAFLRGRSLGEGWSTAKSIAAMADVSTITVLGRAASRAFRQSP
                     AYRWRPMTQFLSPQVMGDTALVPRHPWLEPPSSGETGTAAHIALITAAQGWAEGNDIGS
                     PVRHATPLASQPVVEACLRIPIWWWFRQGQNRVVVRDAFRDRLPAAVVDRRTKGTPDSY
                     IAEIFTANRSIIRAMLLDGHLRRAGLLDLSLLEHVLDGEGYVQGTAYHRIMHLADVEAW
                     VAGQTQD"
     gene            complement(14624..16729)
                     /locus_tag="TZ53_RS02185"
                     /old_locus_tag="TZ53_02180"
     CDS             complement(14624..16729)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041126.1"
                     /locus_tag="TZ53_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02180"
                     /product="Atxe2 family lasso peptide isopeptidase"
                     /protein_id="WP_238320103.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.7e-16, bitscore:
                     58.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRTSIALLAAGVGLLALPSTATADCSDLLPVPAPMTKRRAITAQ
                     DLLGVRDIGRGDGALLGNKSPLGVSPDGRQLAFILIRAEASTNSYCIGLAVMDVKPSAK
                     PRLLDQGGEFIGGTGDYRGVILPTGFPILLAPCWSPDGRWIAFLRRDKGVTQLWTVRAD
                     GGPARAVTHSPVDVEQFAWGPDGRSLIYASRTGQMAERTALAREAVAGFRYDDRYVPMM
                     GDKPMPLATTALSLFRVDPGGGEARPGEEGDRALLGPDPIGYAILPLSARADDGRFIQT
                     EHVTANPASPWALAMFSAAGVKIPCPGEACRGKFAGLWWMSHDGPLLFLRREGWNDRST
                     ALYRWRLGSGPPRRIFVTSDVISGCELAGGDLVCLRQGASVPARIVRIDPGDGRTDLLY
                     DPNPEYRSIRFGRVERLEWRNDLGLEVAGDLALPPDYDGRERLPMIVTTYRSNGFLRGA
                     TGNEYPIHLFAAKGFAVLSLDRPPHVGAINPLNKDWQKLLAENDRDWGERRSMQSSVMT
                     GVQRVIDMGIADPDRTGITGLSDGSSTVGFALINSRRFAAAAISTCCLEPWTVNATIGP
                     AFARKMRSQGFPPATSDDRDYWEPGSMIRNAASIDTPLLMQLADREYLTAIDVFAALRE
                     QGKPVDMYVFPDEFHNKWQPRHRLAIYERNVDWFLYWLQGKKDPDPRKAEQYAIWDRLR
                     LKQPFPP"
     misc_feature    16734..16749
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.43"
                     /tool="antismash"
     gene            complement(16735..19305)
                     /locus_tag="TZ53_RS02190"
                     /old_locus_tag="TZ53_02185"
     CDS             complement(16735..19305)
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1082:
                     TonB-dependent siderophore receptor family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041127.1"
                     /locus_tag="TZ53_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02185"
                     /product="TonB-dependent receptor"
                     /protein_id="WP_044660281.1"
                     /transl_table=11
                     /translation="MSRFSLSALYLSGSIVAAALAVSAPAALAQHSSSIAMVLPAQPLG
                     ASIRELALRSGQTILIDADLVEGVNGPALQGAFTVEAALDRLLAGTGLVWTRIEGSIVI
                     RKGRGSGQDGESGEGASLLGTGSRIRGAPIPSPVMVLDNRAIRDSGLADLGDVARSLPQ
                     SFGGGQNPGVGFNVPSSTGGNVGGGSSVNLRGLGSDATLTVLNGRRVPYDSARQGVDIS
                     AIPLAAVDRIEVVADGASAIYGSDAVGGVVNVILRRDYDGVQTRARIGGSPDGGNFQQQ
                     YGVLAGSRWNGGGGFLTYEYGRNTALMTNQRKYGRIRPDLTLLPASRRHAVAGSIHQDI
                     SDNLTIELDGLYNQRTGEFSYPTSAAANLSVSRITQSYDSYTLAFSGAARLSLGQWQLS
                     LSSSFGKGRTYFQGDTFINDRFLSRAFGRYNNRTMTGEIAGDGPLFGLPGGDAKLALGA
                     GIRANDFAIFRGVGNINNARPSQDSVYAFGEASFPLIGPAQALPLMRSLSLSAALRYER
                     YRGLADVVTPKFGMIYAPTDFLDIKASWGRSFRAPSFIQLYSIEQAILYPITTFGGRGY
                     PAGTTALLIAGGNSDLKPEKARSWSVTMALRPPVLPGASFELSYFHTRYVDRIVNPIPT
                     SALALVNPIYARQISYAPTAAQLAAAIAHASQFLNGAGVPYDPAKVAAIINRANINAGR
                     QTIRGIDAQLAYRTGLANGNIEMSANLTYLDSAQQLLADGPVEQLAGRLFNPPHWRGRG
                     MIGWSKGGFRTAATLSTIGGVKDVRSTPALHIDGMTTIDISARYRFGEEGGLLRGVELG
                     LSVQNILNALSSVVATSLYYDTPYDSTNYSAVGRFIALELVKKW"
     misc_feature    complement(19377..19390)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.75"
                     /tool="antismash"
     misc_feature    complement(19378..19391)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.34"
                     /tool="antismash"
     gene            complement(19383..20390)
                     /locus_tag="TZ53_RS02195"
                     /old_locus_tag="TZ53_02190"
     CDS             complement(19383..20390)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041128.1"
                     /locus_tag="TZ53_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02190"
                     /product="FecR domain-containing protein"
                     /protein_id="WP_044660282.1"
                     /transl_table=11
                     /translation="MTEPGGTEIPQSIHEAAEKWLARRAGQSDPALERDFALWIDADPR
                     HRIAYDLIKRNWQLGTLLQERHVGRNRSLPRAPFWMRQKTHIVAAGLGAAVLLGVASVS
                     LLRSGGPLGISMAAEAAVYETAVGEIRTISLADGSTVILDTASRLRVQLSGSQRRLDLD
                     RGRARFEVAGDERHVFRVRVAGGEIVAHGTMFDVSLIGAHPLVTVIDGSVELHRSDASA
                     ETRAFGPGQSVALDGHRTGQAVSAVEARWVSGMLALDATPLAEAVAAINRYNRIQIRLA
                     EPFAMPLRVTGAFRVRDPEGFARAVAASFHLEVERPDRATILLMAPPKRAGSNM"
     gene            complement(20383..20964)
                     /locus_tag="TZ53_RS02200"
                     /old_locus_tag="TZ53_02195"
     CDS             complement(20383..20964)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1126:
                     extracytoplasmic-function sigma-70 factor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041129.1"
                     /locus_tag="TZ53_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02195"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_044660283.1"
                     /transl_table=11
                     /translation="MIRPASEMARLPLDEGDPLPPEHDRAAFSPDPLASLYREERPSLL
                     RFLSRWTGHDKAEDVIQQVFSRMAGSSDHDGRAIRAPGAYLRQAARNVLRDEARAAERH
                     CAHQHVPIEDLALSGGDPVAALEARDRLVRIEEAVLRLKPLTREIFLACRLDGYSYAEI
                     AERTGLSVRGVEKQMSRAIRQLGRHLRAHD"
     misc_feature    21061..21079
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            21700..21894
                     /locus_tag="TZ53_RS26600"
     CDS             21700..21894
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TZ53_RS26600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157009763.1"
                     /transl_table=11
                     /translation="MMPELRPFKNTKLSNPGMLELIALRIYCPTPRRTLKGAARQQALG
                     GTIRATAAKGTSPCRQDVA"
     gene            22028..23170
                     /locus_tag="TZ53_RS02205"
                     /old_locus_tag="TZ53_02200"
     CDS             22028..23170
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013041065.1"
                     /locus_tag="TZ53_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02200"
                     /product="site-specific integrase"
                     /protein_id="WP_238320104.1"
                     /transl_table=11
                     /translation="MDAPDLRETWRALHPCVRKDARDRVTISAAAGEDHMLSIRTRGKN
                     GIYYIRGTVTLGDKHIIVKEFSSGTSDRDAAAHLMAEHETKLRHRLMFGPAAIVAQGKI
                     ADAFESYLTKAKPPCPSDILRIGKLNGLIGDFSLREPKQAWEHFRRAYLTGHDPAGQDR
                     YRAVFQAAINVHHELHDLPPLRIKAIPFNNERVRFLSKEDRDRLIAAYSPHIQPIITLL
                     AFHGPRIQTALQLPWGVEGVDMEQGSIRLNHSKNAVIRSVPMHPRVMDVLRPIWEKQGQ
                     PTTGHVFLNRFGKPYQDTRKAKTPGGNPIKNQHATACKRAGVEDFTVHDWRHHWASHCV
                     MAGIDLITIMNMGGWKSLRMVQRYSSVSVDHMRESINKLS"
     gene            complement(23189..23836)
                     /locus_tag="TZ53_RS02210"
                     /old_locus_tag="TZ53_02205"
     CDS             complement(23189..23836)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006967591.1"
                     /locus_tag="TZ53_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TZ53_02205"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_044660285.1"
                     /transl_table=11
                     /translation="MIICRNLKKSYSHGGRRKQVFDGVNLTVRRGERIALLGRNGAGKS
                     TLIKLIGGVEMPTSGKITRTMSVSWPLGFAGGFQGSLTGYDNARFIARIYERDYADIRA
                     FVEDFSELGSQLKMPVKTYSSGMRARLAFALSLAIEFECYLIDEIILVGDQNFQQKCRV
                     EMFEKREDRAMIIASHDMGFMRGFCNSAVILHEGTLTKYDDVNLAVDNYSNL"
     misc_feature    23805..23818
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.02"
                     /tool="antismash"
     misc_feature    23936..23948
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    complement(24298..24312)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 20.76"
                     /tool="antismash"
ORIGIN
        1 gactgtcggc ctcgttccat gcgaccgaat tcagtttcgc caattacggg acgatcgaac
       61 cgggccttaa cagctatctc ccttcggtct cgctctcact cggccagagc tattatagcg
      121 gtactgacac taatgccgac aaagcgacga tcagcaacgg cgggagcctg acgaacgcga
      181 tcgatgccgc aatcgcggcc aaggcgctgg ctttcagcaa cagcggtacg atcggttcat
      241 ccctttacgg cgcggccgtc ttgctcaccc aaacggcgca tgagacccgt gacatgacgc
      301 agggtctcta tggggcaatc gatcaggaaa gcctgtcctt tgctaatagc ggtacgttga
      361 acggcagcgc ttatctctat tcgagcgcga ccgccattgc cgtcaccaat agcgggacaa
      421 tcgacgcgcc aatcagcagc cttgtccagc tggatgaccc ggctctgagg atcgaaggca
      481 gcagccaggc caaccagacc gtcgccttca gcaatagcgg gcagatcagc accagccgtc
      541 tgggcgcttc ggcggtttca atcgagagtg atgcgcgatc ggccgagcag caaatgaacg
      601 gctttgacgc ggccgagggc ccgatcgccg gcgaaccaac cacgacgatc aacgtgacca
      661 acagcggcac gctgagcgct gacggcggtg ccagttatcg tcctgcgacc acgccgccct
      721 acccttggta tccttcattc ccggaaagcc ttaccctcgc cgccgcgctc agcatcgatg
      781 cctcgagcgg cggccagtcc agcatcaccg tgaccaatga ggcaggcggg atcatctccg
      841 ccgtcggtgc gacccgcaat gccgccaatg cgcaaaatcc tgtggtcgcg ggcctggaga
      901 atgtcggttc gaccgctttt gttggcagcg cgaatcagat cacgctggtc aatgccggga
      961 cgatccgcgg ccttcaaggc gggattgtgc ctgccagtct gcaggtcgat ccgaccgcat
     1021 ccgaccatga tttcgcaggc cagttcctcg ccggcgcgat ccagacgatc aactcggctg
     1081 acaacgtcac caacctcgcc acgggcgtga tcaccggctc ggtcgatctg ggcgtgttgg
     1141 acgacagaat ggccaattac ggcaccatca acggcaatgt gtatctgggc gaaggcaatg
     1201 accgcttcac ccatggcctg ggcgcgacac tcaacggcac tgtcgatggc ggcaccggca
     1261 ccgacgcact ggtcatcgac atcactggcg gtggcctgct caaccagccg accctcgaca
     1321 agttcgtgaa cttcgaagaa cagtccatca ccggcaccgg caccatcact accgatggcc
     1381 cgctttcgat cgccagcctt gtgctgcgcg acgccaacct taccctggcc gccggacaga
     1441 cgctcaagac cgcaagcgac accagcatcg tctttgcctc cggtaccaac agtctcgcca
     1501 atctcggcac catcgcaggc tccctgaact tcgcagcagg cacgaacagt tttgtcaatc
     1561 tgggcagcat tgcaggaccc gtcacccttg gcggggggag caacagcttc acggtgggtg
     1621 ccggatcctc ggtcagcggg ccggtcatcg ccaatggcac cgacgatctg ctgatcctgg
     1681 cggggggcgg caccgacgcg gcaccgcagg aatcgcgcct gtccggcttc acgggcttcg
     1741 aacgcacgcg gcaggacagc ggcacgctcg ctctgtcggg cgacttcacc accgggcaac
     1801 tgacccttgt cggcggccgc tttatcagcc gcaccggatc ggtgctcaac gctccctcca
     1861 tcctggtcaa ccaaggcgcg acctttggca gcgcggggac cgtcaacggc aatatcatgg
     1921 tgcagggcac cctctccccc ggcgcctctc cgggcacgat gacggtcaac ggcaatgtcg
     1981 cgctggcggg tagctccacc accctgttcg agatgacgcc gaccatcagt gatgcgctca
     2041 tcatcaatgg tacgctcagc atcgcgccgg gtgcgacgct gaagatcacc ggcaatcgtc
     2101 cgctgacccc tggcgtcacc tatgaactga tcaccgccac cagcggcatt accggcagct
     2161 tcgccaccat cgacaaggca tccagcgttg tgggctttgt ccggcagggc gatcacagta
     2221 tcgacctgct gggccagttc gtgcttggca gcggcgccag cggccaggtc acgcagacgg
     2281 tcaattatct gaacgacctg ctgatcgccg gcaccgcaac cagcggcatt ttgaatgcgg
     2341 cgccttcctt gttgctggca gatggtacgg tcaatcaggc agccgccgct cgcctcaacg
     2401 cggaaagcta tgcttccgct tcgcagatcg gcatcgaaaa tggcctggcc atcgcctcgg
     2461 ccctgcgcac cgcctcgacc agcgcgcggg gtgaggaaac gggcctcttc accttcggcc
     2521 agacgctcgg cggctggcgc cgcctccccg gcgacgcggc gctcggcacc gcgcgagcga
     2581 atatctcgac ctatggcgcg cttgccggca tcggtctcgg ctcacagaca gcctcgctcg
     2641 gcgcgttcgt cggctatatc gacgtccgcc agcagatcgg tgcgcttcag gccaggacca
     2701 aggccgaagg tatcatggcc ggcgcagtcg cgcaggcgtc gcttggccgt ttccatgtcg
     2761 ccgcctcgtt cagctacgac ggcagcaagg ccgacaccga ccgcagcctg ctcagcagca
     2821 gcaaactcag cagccattat cgcttgcgca gctggacggc ggatatttcg ctgggccatg
     2881 ccttcgctct gaacgatggc tggagcttcg aacccgaggt cggcttcacg catgtctcct
     2941 cgcgccgcgg cagcgcgagc gagacgggtg atgctgtctg ggcactggat gtccagaggc
     3001 ggcggaccaa ggccagcttc ctgcgcggcg cgctcgaact gcatggcccg gccgaggctc
     3061 gcatcaatcc atggctttcc gcgggcgttc tgcatcagct gagcggcaac agcagcttcg
     3121 cgactgctgc ctatgctggc gtatccgatg acctgactgt cgcgggcgtg agccgcagca
     3181 ggacgctagc cacggtcgga gcaggcgtga acctgcgggt ttcgtcggcg gcaaccctct
     3241 ttttcagcgg caacagcgaa tttggagccg aaagcagcgg tcaaaacctc actgcgggcc
     3301 tgaggatccg tttctgaaga tccaatatta gcaaagcggt gcgcccaact tatcagagaa
     3361 ggttcacgtt cccatgaacg atgccggtct tgccgatgcg cttgccgccg atcacggcat
     3421 ctccaaggct gacgcccgca atatggggat gccgtcttcg ccgccatcgt ccattctgcc
     3481 agcaagggtc acgaagtgtc cctgagcgga ttcggcaagt tcaaggtcag gcacaacccg
     3541 gcccgcgagg gccgcaaccc cgcgaccggt gagacgatcc agatctcggc atcaaggcag
     3601 cctggtttca ccgcagccaa ggccgtcaag gatcagctca accgctaatg ccccagtcaa
     3661 ctgcggtgcc gtggtcatgc gcggcgccga cattacggca ccgagcatcg gtcagacgcc
     3721 accactcaac acccctccca gcgtgcccag gcgacgctag cgcctgccac atcaggccgc
     3781 gcgatcagtc cctgtgccct gccatcacca gcgcccaata tgatcgcgct gaaccaggcg
     3841 cgatgaaaga tcagcgtccc gcttcgatcg ggcaattgat ctgctgatgt cggaaaggca
     3901 catccccaga tgcggtccca gcaatctggg caatcctcag gccaagggca tgcagggttc
     3961 cagggtctga tccacagcag gcggaatccg ggcacagctc agtctgaagc aattgatgca
     4021 gcaagatcgc gacccgatcg ggatcaacgc cgtaccgcga aaagcgggtc ggaattcgcc
     4081 cttccctcgc ccggcgcctc tgccttctcg ggtacaggct ctccggccag ataaataaaa
     4141 aggggcggcg gatttgcgac cggtgagggt ggcggtaacg ccgtaggata gggtccgatc
     4201 agtgatgcga gggtcatcat ataggcgcgc gtttccggcg gcaacggccg gcctttgatg
     4261 agaaattgcc gatagcgctc gggaccagca tgataggcac cgaacagccc cggatagccg
     4321 aagcgctggt tcatggcggc aagataggcg gtgcccgcga ggatattgtc atggggattg
     4381 tgtggattct gcccgagccc atgaagcctt cgcatgtccg cccaggttcc gggcatcagc
     4441 tgcatgagcc ccatggcccc ggcggagctg gtgatgggct tgccttgcca gaccgtgcgg
     4501 ccgccgctct ccgcgcgcat gaccgcctcg acccatagcc ggtcgatccc gaaacgggcc
     4561 gacgcctcgg ctatctctcc ggcccagtcg gcaactgggt cggcgtgcag cggcgttgcc
     4621 cagaggatca gccccgttgc gatcgaccgc aggcatcgcg tcagcccagc catagcgggc
     4681 tcgccttgcc gatgatgtcg gcctctccca ccggcccgaa atagcggccg tcgaaagatg
     4741 ccggaacctt gtccatgagg aggaaatagc ggccgggacg cagaccctcg cagccctccc
     4801 accagggcaa ggtccggccc atgctgtcat gcaggaggcg tctggcgacc agctttccgt
     4861 ccagcatcac cccgtcgccg cgcgcgcaga cgatgtcgcc cggaacgccg ataacgcgct
     4921 ttaccagcgg caagttcatg gggagataat gccgccgcgc ggcaagcagg cgggccggat
     4981 agggcgcgcg cgcgagcacc atgtcgccgc gcgcgagcct tgcccccggg tacaccaggt
     5041 agaaaccgac cggggcgctc gcagtcgcat tccagaccag gcgcggggat ggcgggaagg
     5101 caatggtcgc ccccagcgca aacgcgccca gcccgatcca gatggcatgg cgccgcaggc
     5161 ggcggcgcct tgcgcgtgcc gcgcgcaacg cctcacccca ggcgaaaagc gggaggtcgc
     5221 gaggccgact catgcgcctt ctcccgacct gtgggccgcc gaccaggcat caagatcatc
     5281 gacatgataa cgccagcttc cgccatgcat gcggcagagc ggcccccgcc cctgatggcg
     5341 caagcgcttc agggtgttgg cggcgatccc cagatgaaag gccgcctgct tggcggtcag
     5401 ataggggcag gtattccgcg cgacccgggc gcgctcggcc aggtcccgca gttgggcgcc
     5461 gggccgttcc ttcgcatgat cttccattgc tgttttcctt cgcgacccgg ccccggaagg
     5521 ggcatgtggg tcagatcggc ccatgctggg gcgatccggc ccatcgcggc acggtcggaa
     5581 aatggggggc gcccttttcg acccccgtcg cgatcatccg gtcccggccg catggaaagc
     5641 ggccgggacc ggcgacggac catcagtcag ccggattcca gatgatggcg aaggcatcct
     5701 catcatcctg cccggcggcc cggcccagat tggcgtagag tcggcggggt ccgaattccg
     5761 gggcggcaag gctgagcgat acatagtcct tgccggaggt ttcactgatc cggatccagc
     5821 ccgccccgat ctcaaccccc gacgccagga cgcgatagtc gggctgggta ctgccattct
     5881 tgtggctgtt ggggatgatc tcgacatcgg tgcgaatcga gagggtgcga agctggccct
     5941 tgaagccatt tccgttgcgg gtgacataac cgattgcagc cattttctgt ctcctgtcgt
     6001 gtgcccgcga accatttccg ggcgacagca ggccaggagg gccgggccgc aaaggcctca
     6061 cgcaccgcag gccgaagcgt cagcgaagga ccggccggcc agccttattt ggtccgcgag
     6121 gagccctgcc aggggtgggg aaataaggcg cagccgagcc ggttgcggga gggtgggccc
     6181 ggcccagaag cctgcttttc aaggcgccgg gatggatcgc gcggcagcac aatcgggaaa
     6241 cgatggcatg catggcccgt cagtccgaca accagaaaag aaggccgcgt tgcatcatgc
     6301 cacagttcgc ttcgaacgat tgcatcggca tcatcaagcg ggcgcgcaat tcataggaaa
     6361 ggaggatcat gccgccctcc catccatggg cgtggcggca atggcgggat cagcctcgcc
     6421 ctctccaccc acgccctgcc gggcagcgcg atgcttctcc agcagccagt cggcggcaag
     6481 gctgccctgc cgatcctctg ctctcctatt tcggtcgcat cagcagccga tagccgccct
     6541 gcgccatggc gcgggcggat ttcaccatgc gccgcacgcg ctggcgcaca tggtcggtcc
     6601 ggccttccca gcccgcttcc accgccagtg ccccgaacaa ggctttgccg atttcgcggt
     6661 ggctggcccc cgacgcgcgc gcatcatgga cgcgcagcag cgccaatccc cgcccgatca
     6721 cgggatcagc gggatagagc ggcgcgcgaa accggccagt cctgaccaga tcaagaaagc
     6781 gctcgagcgt tctcaggcgc cgggccgcca tttgcgagcc ccatatctca taatgcagca
     6841 acacagcgcc ccgggtgtgg gtcaggctgc ctgccatgat gtcgattctc agatgccgaa
     6901 gcccatcgct tagcacggca tgttcccggc ccatggtatc ggtcgcgatc cgcagccacg
     6961 gcagcagctg cccaagctcg attctttcct ccaccggcgc agaatggttg gcgatgacga
     7021 caggcagggt cgcaggatcg atatccgcac gccagatgat ccgagcctcc ggtgccggga
     7081 ggtcgggatg ttcagcgaaa gtgaagcccc catggcgacg ggtccacggc acctctggtg
     7141 atgcggctcg cctgcgcatg ccaggcgaca tagtccggat cgcggcgcag ccattcccac
     7201 atcagtcccg cgcgatcgat tccgcgcagc ccggcatagc atgccggatc ctgccaattt
     7261 tcggcggcag gacccgcagc gctccgtctc accgctcgct ttccgggcga accggcggcg
     7321 ctttggccgc tttgaatgat cgaagtcggc gatctttgct gcacggcagc aaatatgtcc
     7381 ccggacagaa aaaaccatga tatgtcagtt tcatgacaaa acctgccggt cggcggcatg
     7441 aggccccgcc tttcggccac aacaatgagg aaaggccgac tgcaggacgc gcggcagctt
     7501 gagatgccgc ctgcggccgg gacgcgtgcg catgagcatg catcaggaag cgatgcattt
     7561 cctccaatgc atcaaccagg ttcggacgcg cgatgacatg gggtccgtca tgcgcgtgat
     7621 tgcagagcag ctgggctttc aatattttgc cctgacccag catgtcgatg tggtcgcggc
     7681 gggcagcggc gtgatccaca tccacaatta tcccgaccgt tgggcggatt tctatgccgc
     7741 gaacgcgctg ggcatcaccg atcccgtcca cagggcctgc catatgacca gctgggggtt
     7801 tcgctggaca cagatgcccg ccctcattcc cttgacgagc ggcgaccaca ggcatctcgc
     7861 acgcggaagg caggcgggga tcggcgacgg ttttaccatt ccctccaata tcgggttagc
     7921 gtccgcgctc gtggtgtaat ttctggtgta gattgagatg atcgcatggg gtggggcatg
     7981 ccccacccca tgcgatttcg atctcggtgg ccaccgggct catcggtaag gtggagttac
     8041 cacacttcac acgcccaccg aggagttgat cccgatgacc gacgacagac taccgcttgc
     8101 cgagctgatg gcgaagactg gagatggaga tttcctgcgc acgatcgccg agagcgtatt
     8161 acagatcatc atggaggccg acgtcgatgg cctggtcggc gctagccgac acgagcgctc
     8221 cggcgaccgg acgacctggc ggaacggcta ccgcgaccgc agcctcgata cccggctcgg
     8281 cacgctcaac ctgaggattc ccaagctacg gaccggcgcc tacttccctg gcttcctgga
     8341 acccaggaag accgtcgaga aggcgctggt cgcggtgatc caggaggcgt ggatcgccgg
     8401 cgtcagcacc cggcgtgtcg acgagctggt gcaggccatg ggcatgaccg gcatctccaa
     8461 atcctcggtg tccaagctgt gcaaggatat cgacgaacgt gtccatgcct tccttaagcg
     8521 gccgctcacc ggcgactggc cctacctctg gctcgatgct acctacctca aggtgcgcga
     8581 gggcgggcgg atcgtcagtg tcgccgcgat aatagccgtt gccgtcaaca ccgagggcaa
     8641 gcgcgaaatc gttggccttc acattggacc ctccgaagcc gagccattct ggtcgagctt
     8701 cctcaaggac ctcgcacgcc gcggactgac cggcgtgaag ctggtcatct ccgatgccca
     8761 cgagggcctc aaggcagcga tcactcgcgt gctcagcgcc acctggcagc ggtgccgcgt
     8821 ccacttcatg cgcaatgccc tggcctacgt gcccaagggc cagaacaccg tcgtcgccgc
     8881 tgccatccgc caggtcttcc tccagcccga ccatgccgcc gcgacacagg tctggcgcca
     8941 ggtcgccgac cagttgcgta cccgctggcc aaagctcggc gcctgcatgg acgatgccga
     9001 gcacgacgtg ctggcctaca tgaccttccc cgagcagcac cgcgtcaaat tacattccac
     9061 caatccactg gaacgcctga acaaggaagt gaagcgccgc gccgatgtcg tcggcatctt
     9121 cccgaacgag gatagcatca tccgcctcgt cggcgccgtc ctgctggagc agaatgacga
     9181 ataccagctc cagcaccgct acatgcagat cgagggcatg gccgcccttg ctacaccaat
     9241 gatcgaggag gcacagccgc tacagattac acccaaggcc gcctgaaaat gcagcccgct
     9301 ggccacaccc aattctacac cacattgacg gacgcgacca atatcggtgg gcagccccca
     9361 gggtcctgca ccttcgccaa tgcgggcgat cgtcccctgc gcgaggacag gctcctcctg
     9421 gcgcaactgc ttggcaatta tgcgttcgat gccgctcggc gactctggtc gatgccccga
     9481 caggccatga ccgcgccgct catcaccgat cggcagcgcg actgcgtgca gtgggcggcg
     9541 cgaggcaaga gcgactggga gaccagccag atattggaca tcagcaggga aaccgtgacg
     9601 agccatatca aggaagcctg tgcacgctac caggtcaaca agcggatatt gctcgtcggc
     9661 cggacgctgg gtgacggaac cctgacgatc agcgacattg gcggctggag ccatccccat
     9721 ttctgggaat agcggcgact cagcctccga accgaccctt gatcgcccat gaccaaggga
     9781 gcttatccat gttgcatatt gtgaaagaac cgttccggcc gctgccggac accgtgttgc
     9841 gcgccatgtt cgcggcccgc aaatccgtct tcgtcgatct cctcaaatgg cagattccgg
     9901 ttctcgacgg ccggttcgag gtcgaccagt ttgacgagaa catgcgcgct acatcatcct
     9961 gtccgaaccc gacggcaccc atctcgcctc ggcgaggctg ctgccgaccc agcgccccca
    10021 tattctcgac agcttctacg ccagattatg cgacgcgcca ccgccgcgcg gcggggacat
    10081 tttcgagatc acccgcttct gcctcgaccg gaacctgcgg gcggccgaac ggcgggtggt
    10141 ccgcaaccgc cttgtgaccg cgatcgcgga gcatgcgctg gagaaccgca tcagccgcta
    10201 tgtcgccatc gccgagatga actggttcca gcagatcctg gcctttggct ggcaatgccg
    10261 gccattgggc gcgccgcaat ggcatgaggg ctcgctgctc gtcgcgttgg agatagagat
    10321 gggcgcggac acgctcgacc ggctcgctga ggccgggatc tatgatcagg caccgatggc
    10381 agcgtgagac gggagacgcg atcatgaccg aaccccttcc cacgagtgcg tcgcgcctga
    10441 tcgagcaatt gttcgaccag ggctggtccg tcctaccgca cgccttgccc gaaggcgtca
    10501 tcgccgcgct ggacgcagat ctctcgccct cttttgcgga gactcccttc tgccagggac
    10561 cattttatgg cgagacgacc aagcgcttcg gacggctgct gacgcggtcg tcccatgcag
    10621 aagccctggt gcggcatccg ctcatcaccc ggatcgcccg gcagattctc gccccctggt
    10681 gcgactgcat ccagctcaat gtcgggcagg ccatcgccat ccaccccggc gcgccggcgc
    10741 aggcacccca tcgcgaccag gatatgtggc aagcgcccaa gggagagatc gaatatctgg
    10801 tcaatatcat ctggccattg acgcccttca ccgccgataa tggcgcgacg ctggtctggc
    10861 cgcgcagcca cggcgcccag gcgctcctgc ccggtccagt cacagatccg atcgcggtcg
    10921 ggatggagcc cggctctgcc ctcatcctgc tgggatcaac cctgcacggt gccggcgcga
    10981 accggaccgc tgcggtgcgg cgcgcgatcg tcacgggcta tagtctggga tggctcaaac
    11041 cctatgaaaa tccttggctt gcctatccgc ccgcagtcgc acgccggttt tctcctgaac
    11101 tggccgcgct cgccggctat cgccagcacc gccccaatct cggcaatttc gagggacagt
    11161 gtccctcggt cctgttgact ggcgcgcctg atcgcccgct ggccgccatc gatgcgctgc
    11221 ggccggacca gcaggacatg gtggcggcct ttgcggcgcg gcaaagctga atcaggatga
    11281 acgccggtcc aacctccgag cgggttcagc agagtctcag gcgcctcatc atggaacggg
    11341 gctatcgtcc cggatcccgt ctcgatcctg cggagctttc cgcaatcctg gcatcgagca
    11401 cgacaccgat ccgggaggcg ctcaaccatc tggcgggcga gggccttgtc gaagcgcgaa
    11461 gcggcggggg cttccttgtg ccgctgatcg acgagccggg cctcaaggat ctctacgcct
    11521 ggtcgggcga catcgtccag ctcgccctgc gtagcgcccg cctttcgctg ctgcgagcga
    11581 tcgaactcga cccggatttc gcatcgggcg cagaccgggc cgcgcacctc cttcaccgaa
    11641 tcgcgagcgc ctccagcaat cgcgaacatg gcgaagcgat ggaacgcacc aacgcccgcc
    11701 ttcatgtcgc gcgtatcggc gaagaagaca ttctgggcga cactggggaa gaattgcagg
    11761 cgctggcgca cagcgcgcgc gccggtgaca tcgggctgct gcgcaggacc tcatcgacct
    11821 atcatctgcg ccgccagcgc gccgcggcaa aactgcttcg cggcatctat cgagacgaat
    11881 aacaggcggg acattccgcc tgcaacttgt cgaagaggaa tatccattcc tcccgatcat
    11941 tccatatgtt cgcgatatcg gatccgtata aatttcggat agggccgtcc gcttcctacg
    12001 ctccatggtg ctgcaaatag tcgcagcaaa accaaggagt gactatcatg gaacgtgaca
    12061 atgacgtgat cgaactcggc gcggtcagcg tggaaaccaa ggggcccggc ggcatcaccg
    12121 gcgatgtcgg gcttggtgaa aataatttcg gcctttccga cgactgaagc gatggcgcgc
    12181 agcttcgcgg ctgcgcgcct cgcccgttcg agacacagaa tgagcggcta tacactgcgc
    12241 gatggtctga gcttctgccg gaccgaggga catgtcattt tcctcgacct ccatgccgat
    12301 cgctatttcg gcttgcggcc agcgctggac caagcgttca gatccctcat cgacgccaac
    12361 cacatcgatg cccggcagtg cgacgcgttg ctggaagcgg gcatcatcat ccggtcgccg
    12421 gtcggtatca ggcccgcccc ctgcccgcgc tcgcatgcat ccgaggccag gctgcccatt
    12481 gcgaagccgc gcctgtcacc agcctatctc gcaagcgccc tgacccgccg gttctggtgg
    12541 cgcgcgagac tgagacaatt gcccttctcg cggaacatcc gcttgatcga acagcgcaaa
    12601 tatggcgtgg cgccacggac agccccgacc gaccggcttg cccatattga tcaggcctat
    12661 cgccgggccg ccatgatcgt ctccgcccgt gaccagtgcc tccccaccgc gctgtcgctc
    12721 gcgtcatggc tgatcgcgct cggcatccgg ccggatctcg tcctgggcgt caagctcaac
    12781 cccttccagg ctcatagctg ggtcgaggtc gacggcatgg tcgtcgccga tgatcccgat
    12841 caggtccgtc ccttctgccc gatcaggatc atctgatgga gagatttgtc gccatattcg
    12901 cgccgaaacc ggaacgcagt cctatcgcgc cgccgatccg gagcgcgatt tctcgcgccg
    12961 aggcgctgtc ggtcatgatc gacggggacg atatgctggt cgcaagcggc ggcggacaag
    13021 tccggcatct gggcgatgat atcggcatgg tcatcggtcc cattttcgcg accggcaaga
    13081 gcgatccggc caccccgccc tcggatgtcg cgtccagcgg cgatccgtca gatctccatc
    13141 gcttcagcca ggactattgg ggtaatttcg tcgcgatcct gcgcgatcgc gcggcaggct
    13201 ttcatgttct gcgttcagcc ttcgggcgcc tgccctgctt ccatgcggtg cagggcgatc
    13261 aactcattct cgcttccgac atggccctgc tgtcgcttgg cggatggaaa tcccgtgggg
    13321 tcgaatggtc cgccatattg cgccgtctgg cgcttaagga tatcccctcg ccctccacct
    13381 gcctcatagg cgtgcaggaa ttgcgtggcg gctcccgtct ccatctcacc ccagaagggc
    13441 tgagcgtcac gcagacatgg aacccatggg accgggctgg caggcgccac tggatcgacg
    13501 accgggacga ggccgcgcgc atgatccggc gcgcggtatc gaccgcgacc cgcgccagca
    13561 tcatgggggc caagcgtgcc ctgctcatgc tgtcgggcgg gatagactcc tccgtgctgg
    13621 ccgccgcgct cggcacccat ggctgcccct ttacctgttt caatctcgcc agccgcggcg
    13681 cgatcggcga tgaacgtcat tatgcccgga tggtcgcatc ccatctgggc gcgccgacca
    13741 tcgaagcgca atgggatgct ggcatggtcg acgtcagccg ttcccatacc caggatcaac
    13801 ccaatcccct cgcccgcagc ttcatgcagg gcacctcccg cctgctccat gaggctgtcg
    13861 gggcgagcgg cgccgatctc acgatcgatg gcggcggcgg ggacaatgtc ttcttttccc
    13921 tgcggtccat cgcgccggtg accgacgcct tcctgcgcgg acgaagcctg ggtgaaggct
    13981 ggtctaccgc caagtcgatc gcggccatgg cggatgtgag cacgattacg gtgcttggtc
    14041 gggcagcgtc acgggcgttc cgccagtcgc cggcctatcg ctggcggcct atgacccaat
    14101 ttctgtcccc gcaggtcatg ggcgacacag ctcttgtacc acgccatccc tggctggagc
    14161 cgccaagcag cggtgaaacc gggacggccg cccatatcgc gctcatcacc gccgcccagg
    14221 gctgggcgga aggcaatgat atcgggagcc cggtgcgcca tgcgacgcct ttggcttcgc
    14281 agccggtcgt ggaagcatgc ctgcggatac cgatctggtg gtggttcaga caaggccaga
    14341 accgggtcgt ggtacgggat gcctttcgcg accgcttgcc agcagccgtc gtcgaccgca
    14401 ggacgaaggg cacacccgac agctatatcg cggaaatctt caccgcgaac cgctccatca
    14461 tccgcgccat gctgctcgac ggacatctgc gccgagccgg actgcttgac ctttccctgc
    14521 tcgaacatgt cctggacggc gagggttacg tccagggcac ggcctatcac cgcatcatgc
    14581 atctcgctga cgtcgaggca tgggtggcgg ggcagaccca ggattaggga ggaaagggct
    14641 gttttaggcg cagcctgtcc cagatcgcat attgctccgc cttgcgcgga tcgggatctt
    14701 tcttgccctg aagccagtag aggaaccagt cgacattgcg ttcgtagatc gccagccggt
    14761 gtcgcggctg ccatttatta tgaaattcat cgggaaagac atacatgtcg accggcttac
    14821 cctgttcgcg caaggcggcg aagacgtcga tcgccgtcag atattctcga tccgccagct
    14881 gcatgagcaa tggcgtatcg atcgacgcgg cattgcggat catcgaaccg ggctcccaat
    14941 agtcccgatc gtcggatgtg gcgggcggga aaccctgcga ccgcatcttc cgggcaaagg
    15001 ccgggccgat ggtggcgttc acggtccagg gttcaagaca gcaggtgcta atcgcggcgg
    15061 cggcaaagcg gcggctgttg atgagggcaa agccgaccgt gctcgatcca tcgctcaaac
    15121 cggtgatgcc ggtgcggtcc ggatcggcaa ttcccatgtc gatgacgcgc tgcaccccgg
    15181 tcatgaccga agattgcatg ctgcgcctct ccccccaatc ccggtcattc tcggccaaca
    15241 gcttctgcca gtccttgttg agcgggttga tcgccccgac atggggcggg cggtccaggc
    15301 tgagaacggc aaagcctttc gcggcgaaca gatggatcgg atattcattg ccggtcgcgc
    15361 cccggagaaa tccgttgctg cgataggtcg tcacgatcat gggcagcctc tctcgtccat
    15421 cataatcggg cggcagggca agatcgccgg cgacttccag gcccaggtcg ttccgccatt
    15481 ccagccgctc gaccctgccg aaccggatgg atcgatattc gggattggga tcgtagagca
    15541 gatcggtacg tccgtctccc ggatcgatcc gcacgatccg cgccggcacg ctcgcgccct
    15601 gacgcaagca gacaaggtcc ccacctgcga gctcacagcc gctgatgacg tcgctcgtaa
    15661 caaatattct ccgtggcggg ccggagccaa gccgccagcg atagagcgcc gtcgaccggt
    15721 cattccagcc ctcacggcgc aggaagagca aggggccatc atgggacatc caccaaagcc
    15781 cggcaaactt gccgcgacag gcctcacccg gacaggggat tttcacgcca gccgcagaga
    15841 acatggccag cgcccatggg ctggccggat tggcggtgac atgctccgtc tggataaagc
    15901 gcccatcatc ggccctcgcc gaaagcggaa ggattgcata gccgatcgga tcggggccca
    15961 gcagcgcccg gtcaccttct tcgccgggcc gggcctctcc cccgcccgga tcgacgcgaa
    16021 acagggacag ggctgtcgtg gcgagcggca tgggcttgtc gcccatcatc ggcacatagc
    16081 gatcatcata acgaaagccg gccacggcct cgcgcgccaa tgcggtccgc tccgccatct
    16141 gtccggtccg gctcgcatag atgagcgacc tgccatcagg cccccaggca aattgctcca
    16201 catcgacggg agaatgggtg acggcccggg cgggaccgcc atcggcacgc actgtccaga
    16261 gctgggtgac acccttgtcc cgtcgcagga aggcgatcca ccggccatcg ggcgaccagc
    16321 acggcgcgag caggatcgga aatcccgtcg gcaggatgac cccgcgataa tcgccggtcc
    16381 cgccaataaa ctctccgccc tgatcgagaa gccgcggctt cgcggatggc ttcacatcca
    16441 tcaccgcaag gccgatgcaa tagctattgg tcgatgcctc cgcccggatc aggataaagg
    16501 cgagctgtct gccgtccggg gaaactccga gcgggctctt gttgccaaga agggcgccat
    16561 cgccccgccc gatgtcgcgc acgccgagca ggtcctgcgc cgtgatggcg cgtcgcttcg
    16621 tcatgggcgc agggaccggc agcaggtcgc tgcaatccgc cgtcgccgtg gaaggcaagg
    16681 cgagaagtcc aacgcccgcg gccagcagcg cgatcgatgt cctgtccatg acgctcacca
    16741 tttcttgacc agttcgagcg cgatgaagcg gccgaccgct gaatagttgg tcgagtcata
    16801 gggcgtgtca taatagaggc tggtcgcgac gaccgaagac aaggcattga gaatattctg
    16861 gaccgagagg ccaagctcga cgccgcgcaa cagcccccct tcctcgccaa agcgataacg
    16921 ggcgctgata tcgatcgtcg tcatgccgtc aatgtgcaga gccggggtgg agcgcacatc
    16981 cttgacgccg ccgatcgtgc tgagcgtggc cgcggtgcgg aagccgccct tgctccagcc
    17041 gatcatgccc ctgccgcgcc agtgcggcgg gttgaacaat cgtcccgcca gttgctcgac
    17101 cggaccgtcc gccagaagct gctgcgcgct gtcgagatag gtgagattgg ccgacatctc
    17161 gatgttccca ttggcaaggc cggtcctgta ggcaagctgg gcatcgatgc cccggatcgt
    17221 ctgacgcccg gcattgatat tggcgcgatt gatgatcgcg gcgacctttg ccggatcata
    17281 gggcacgccc gccccgttca gaaactggct cgcatgggcg atcgccgccg caagctgcgc
    17341 tgccgttggc gcatagctga tctgcctggc gtagatcgga ttgacgagcg ccagcgctga
    17401 cgtcgggatc gggttcacga tgcggtcgac atagcgggtg tggaaatagc tgagctcgaa
    17461 ggacgcgccc ggaaggacgg gcggacgcag agccatggtc accgaccagc tgcgcgcctt
    17521 ttccggtttg aggtcgctat tgcccccggc gatcaacaag gcggtggtcc cggcgggata
    17581 gcccctcccc ccgaatgtcg tgattggata aaggatcgcc tgttcgatcg aatagagctg
    17641 gatgaagctt ggcgcccgga aggatcggcc ccagctcgcc ttgatgtcga ggaaatcagt
    17701 cggcgcgtag atcatgccga atttgggtgt cacgacatcg gcaaggccgc gatagcgctc
    17761 atagcgaagc gcggcgctga gactgaggct gcgcatcagc ggcaaggcct gcgcgggccc
    17821 aatgagcggg aagctggcct cgccaaaggc atagacgctg tcctgcgacg gcctggcgtt
    17881 gttgatattg cccacgcccc tgaagattgc gaagtcgttc gcccggatac ccgcgcccag
    17941 ggccagcttg gcgtccccgc ccggcaagcc gaacaagggg ccgtcgcccg cgatctcgcc
    18001 ggtcatcgtc cggttattat agcgcccaaa ggcccggctc aaaaaccgat cgtttatgaa
    18061 cgtatcaccc tgaaaataag tgcgcccctt gccgaaactg ctcgacaggc tgagctgcca
    18121 ctgccccaac gagagccgcg ccgctcccga aaaagccagc gtgtagctgt catagctctg
    18181 ggtgatccgg ctgaccgata gattggcggc tgcgctcgtg ggataggaaa attcaccggt
    18241 ccgctggttg tagaggccgt ccagttcgat ggtcagattg tcgctgatgt cctgatggat
    18301 gcttcccgcg accgcgtggc ggcggctggc cggcagcaag gtcaggtccg gcctgatccg
    18361 gccatatttg cgctggttcg tcatgagggc agtgttccgg ccatattcat aggtcaggaa
    18421 gccgccgccg ccgttccagc ggctacccgc cagcacgcca tattgctgct ggaaattccc
    18481 gccatcgggc gatccgccga tgcgagcccg ggtttgaacg ccgtcataat cgcgcctcag
    18541 gatcacgttg acgacgccgc cgaccgcgtc cgatccgtaa atggccgagg cgccgtccgc
    18601 caccacctca atccgatcga ccgctgcaag cggaatagcg gaaatgtcga cgccctgccg
    18661 ggccgagtca tagggcacac ggcgaccgtt gagcacggtc agcgtcgcgt cgcttcccag
    18721 gccgcgcaga ttgaccgagg acccgccgcc gacattgccg cccgtgctgg acggcacgtt
    18781 gaaaccgacg cccggattct gcccaccgcc aaagctttgt ggcaggctgc gcgcgacatc
    18841 gccaagatcg gcaaggccgc tgtccctgat ggccctgtta tcgagaacca tcacgggcga
    18901 ggggatcggc gcgccgcgga tgcggctgcc cgtgcccagg aggcttgcgc cctcgccgct
    18961 ttccccgtcc tgcccggacc cgcgtccttt ccggataacg atactgccct cgatccgcgt
    19021 ccagacaaga ccggttccgg caagcagtcg atccagggct gcctccaccg tgaacgcgcc
    19081 ctgcagggct gggccattca ccccctcgac aaggtccgca tcgataagga ttgtctgccc
    19141 ggagcgcagg gccagttcac gaatcgacgc accaagcggc tgagcgggca acaccattgc
    19201 gatgctggaa gaatgctgtg ccagcgctgc cggggcgctg accgcgagcg cagcggcgac
    19261 gatactgccg gacagatata gagcggataa tgaaaatcga gacatttggc cttctccccc
    19321 ttgccgccag tgggcgggac agtggggaga cgccggcttg ctaaaacacc cgacagattt
    19381 ttttacatat tcgatcccgc ccgcttgggc ggcgccatca gcaggatcgt ggcgcggtcg
    19441 ggccgctcca cctcgagatg gaaactggcc gcgacagcgc gcgcgaaccc ttccggatcg
    19501 cgaaccctaa atgcacccgt cacgcgcagc ggcatggcaa agggctcggc cagccggatc
    19561 tgtatcctgt tgtagcggtt gatcgctgcc accgcctcgg caaggggcgt cgcatcgagc
    19621 gccagcatgc ccgataccca tcgcgcctcc accgccgata cggcctgccc ggtcctatgc
    19681 ccatcaagcg cgacgctctg tcccggtcca aacgcccttg tctctgcact ggcatcggat
    19741 cggtgcaatt ccactgaccc atcgataacg gtaaccaagg gatgcgcacc gatcaggctg
    19801 acgtcgaaca tcgtgccatg ggcgacaatc tcgccacccg cgacccgcac acggaagacg
    19861 tgcctctcat ccccagcgac ctcgaaacgc gcccgccccc ggtcgaggtc gagccgccgt
    19921 tggctgccgg acaattgcac gcgaagccgc gaggccgtgt cgaggatgac ggttgatccg
    19981 tccgcaaggc tgatcgtccg gatctcgccc actgccgttt catagacggc ggcctcagcc
    20041 gccatggaaa tgcccaaggg gccgccggac cgcaagaggc tgaccgacgc cacccccagc
    20101 agcaccgcag cgccaagtcc ggcagccacg atatgcgtct tctgccgcat ccagaatggc
    20161 gcgcgcggaa gcgagcggtt ccggccgaca tgccgttcct ggagcagcgt gccgagctgc
    20221 caattgcgct taatcaggtc ataggcgatg cgatgccggg gatccgcatc gatccagagc
    20281 gcaaaatcgc gctccaatgc cggatcggat tgtccggcac gccgcgccag ccatttttcg
    20341 gcggcttcat ggatggattg gggaatctct gtcccgccgg gctcagtcat gcgcccgcaa
    20401 atgccgtcca agctgcctga tcgccctgct catctgcttc tcgacccctc gcacgctcaa
    20461 tccagtccgt tcggcaatct cggcatagct atagccatca agacggcaag ccagaaatat
    20521 ctcgcgggtc aacggcttca atcgcagcac ggcctcctcg atccggacga gccggtcgcg
    20581 cgcctccagc gcggcgacgg gatcgccacc cgaaagcgcc agatcctcga tcggaacatg
    20641 ctgatgcgca caatggcgtt ctgctgccct ggcctcatcg cgcagcacat tgcgcgcggc
    20701 ctggcggaga taggctccgg gtgcccggat cgctcgacca tcatggtccg aacttccagc
    20761 catgcggctg aaaacctgct ggatgacatc ttccgccttg tcatgccccg tccatcgcga
    20821 gaggaaacgc agcagcgagg gccgctcttc ccgatacagg cttgccagcg ggtccggcga
    20881 gaaagccgca cgatcatgct caggcggcag gggatcaccc tcatccagcg gcaggcgcgc
    20941 catttccgaa gcgggccgta tcatggcctg ctcctgctat ttgttctggc ttgcgatccc
    21001 atccgccgct ccctcgcaca agacgaggtt gcgccggata aaaccgggcg ttgagccgcg
    21061 cttgagaacg cgtgtcgatg cctttggcca taaatggctt ggacataaca tcgaccaccc
    21121 ggccgcttcc gcgacgagtc tatccttccc aagcgagggg ctcaaacctc ggcgccttcc
    21181 aacgaaaacg ccacgacaca ttatcgtaat gtcaagtcgg tgcaacaggt tagagaaaga
    21241 tcgaaatcag ctttgttcca ccctgtccgc atcgcccttg gttgaaatag gcacctctga
    21301 cccgccctaa gttcatgtac gaggacagac cggccgtcca cgtcgagcat cggccggggc
    21361 agcggtccca ctatcggcgc atataagtcc gatccgggcc gatccgggcc gatctggacc
    21421 attcccttgc aggtcgcgga aaagcgatag tcaatcatgg cagcggatcg cttctgcatc
    21481 ccccgacgta gggctggccc gcggccaccg tacatcgtca tgaacaggcc aacgcccgat
    21541 gaagaactac aagacccggc tcctgcccga ggagatgagc aggcggctcg agcatctggc
    21601 gacaagttcg ggtcggacgc ggtcggaagt cctggtcaat gcctgtttca acctgcgaca
    21661 ggcgccaagc tctttgccca gtggccgagg agcttgcaaa tgatgcccga acttcgacca
    21721 ttcaagaaca cgaagctttc aaaccccggc atgctcgagc tgatcgccct gcgcatatac
    21781 tgcccgacgc cgcgccgcac actcaaaggc gcagcgcgcc agcaagccct cggtggaacg
    21841 atacgggcaa cggcagcaaa agggacttct ccatgtcgac aagacgtcgc ctaaccaagt
    21901 cacccggcca agccgatgcg acaacgctgc atagggcacc ggcggctggc gaaacgccga
    21961 cggcaactct cctaaccccg cgtgacatcc tgtcgcggct gaacatgcac agcaccgatc
    22021 ccgcaaaatg gatgcgccgg accttcgtga aacatggcgt gccctacatc catgcgtgcg
    22081 gaaagacgcg cgcgacagag tcacaatatc agctgctgct ggagaagatc acatgctctc
    22141 cattcgcacc cgggggaaga acggcattta ttacatccga ggtaccgtca cgcttggcga
    22201 caagcacatc atcgtcaagg agttcagttc aggaacgagt gaccgcgatg ctgcggcgca
    22261 cctgatggcg gaacatgaaa cgaagctgcg gcaccggctg atgttcggcc cggccgcgat
    22321 cgtggcgcaa ggcaaaatag ccgacgcttt tgaaagctac ctgacgaagg caaagccccc
    22381 ctgcccgtcc gacatcctgc gcatcggcaa gctcaatggc ctcatcggcg acttcagcct
    22441 gcgcgaaccc aaacaagcct gggagcattt ccgccgtgcc tatctgaccg ggcacgatcc
    22501 ggcgggccag gatcgctatc gcgccgtgtt ccaggcggcc atcaatgtcc atcacgagct
    22561 gcacgacctc ccgcccctgc ggatcaaggc gatccccttc aacaatgaac gggtgcgctt
    22621 cctcagcaag gaggaccgcg atcggttgat cgcggcctac tcgccacaca tccagccgat
    22681 tatcacactc ctcgccttcc atggcccacg catccagacg gcattgcagc tcccgtgggg
    22741 tgtcgagggc gtcgatatgg agcaaggatc gatccggctt aaccacagca agaatgccgt
    22801 catccggtcc gttccgatgc atccccgcgt gatggatgtg ctgcgtccga tctgggaaaa
    22861 gcaaggtcag ccgacgacgg ggcatgtctt cctcaatcgg ttcggcaaac cctatcagga
    22921 cacgcgcaag gcgaagaccc ccggcggcaa tccgatcaag aaccagcacg ccaccgcctg
    22981 caagcgcgca ggggtagagg atttcaccgt ccatgactgg cgccaccact gggcatcgca
    23041 ctgcgtcatg gccggtatcg acctcatcac catcatgaac atgggcggct ggaagtcgct
    23101 ccggatggta cagcgttatt ccagcgtcag cgtcgaccat atgcgagaat cgattaacaa
    23161 gctaagctaa gtacaaataa atatttgatt ataaatttga gtaattatca actgccaaat
    23221 ttacgtcatc atatttcgtc aacgttcctt catgtagaat cactgcgcta ttgcagaaac
    23281 ccctcatgaa gcccatatca tgcgaagcga taatcatcgc tctatcttcg cgcttttcga
    23341 acatttctac tcggcatttt tgctgaaaat tctgatcgcc aaccaggatt atctcatcga
    23401 ttagatagca ttcgaactct atcgccagcg acagggcgaa ggccaagcgt gcgcgcatgc
    23461 cggaagaata ggttttcacc ggcatcttca gttggctgcc gagttcgctg aaatcctcta
    23521 caaacgcgcg gatgtcggca taatcgcgtt catagattcg cgcgatgaag cgcgcattgt
    23581 cataaccggt caggctaccc tgaaagccgc cggcaaaacc caagggccaa gataccgaca
    23641 tagtacgggt gatcttgccc gaggtcggca tttcgacgcc gccgatcaat tttatcagtg
    23701 tacttttgcc tgcgccgttt cgacccagca aggctatgcg ctcgccccgt ctgacggtca
    23761 ggttcacgcc atcgaacacc tgcttgcgcc ggccgccatg tgagtaggat ttttttaagt
    23821 tgcggcaaat gatcattcga cggtcaatat acggcgcatg cgacggcaca ggatgaggcc
    23881 gatgactaca aagatggcag agcagacgat cggattccaa ggatcataat aagcagtgat
    23941 cttgtcaccc caaatccctt tccgcatcat ctccatcgca ttcacgaaag gagaaaaaag
    24001 cagaaaattc ctagcggcgg gcgtcaccca cgccaccatg ttaaatgctc ctgaaaaggg
    24061 gatcatgatg taagtcgtga caggaataaa tttttctacc gtttccgata cttcagaaag
    24121 cggcgctaga atgaggcata gagagaagca gaacaggcca tatagcatcc agcctgcaat
    24181 cagcagcccg atatcggaag gtatggggaa ttcgccgatt atgatcagaa acagggctat
    24241 gaacagatag gccatcatgc cgccgacaag ttcgattatg aaccgtgcca tgatgaaatc
    24301 gacgaccttg atctggcgat gatagagcag actttgattg acggtaaagg ccgccacgct
    24361 gcgcgcaacg caatgccgga acaaggttag cggtatatag cccgtcgcta cgaatgcgat
    24421 cacgctgacc ccatgttcgg tggcgccgtg ggtgaaatgc catagcagcc cgacaagtcc
    24481 cgcgaacatc aggggctcag ccatgatcca gagaaagccg atattttccc gcccgaagcg
    24541 ggtgatcagt tcgcgaatca tcaaggcgtg gatgactcga acctgcacgc cccagctatt
    24601 gcgcagttgg tttaagctgc cttttgc
//
