LOCUS       NZ_BBNO01000008        22613 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000008
VERSION     NZ_BBNO01000008.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 724454)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 543836
            Orig. end                         :: 566449
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22613
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="5"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22613
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22613
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12613](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12613
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(249..262)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            425..958
                     /gene="folE"
                     /locus_tag="TU31_RS28650"
                     /old_locus_tag="TPA0598_08_04720"
     CDS             425..958
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088757.1"
                     /locus_tag="TU31_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04720"
                     /product="GTP cyclohydrolase I"
                     /protein_id="WP_042159706.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 6.8e-43,
                     bitscore: 141.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIEEWLKTNVTTDTRALGWYSGPECEDRIVRAYRELLSGYEIDT
                     SKILKTTCLVNGEHTGVVRIQENNFFSICAHHFLPFFGKVNISYVPGDRILGLGKFPRL
                     VQAFSRRFQIQEYLVKDIADEIMSSGGAQAVRVTSSSRHLCMCSRGPSDQTVTTDTSYV
                     AGDQELMARFGLDD"
     misc_feature    complement(444..458)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            1078..2382
                     /locus_tag="TU31_RS28655"
                     /old_locus_tag="TPA0598_08_04730"
     CDS             1078..2382
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601725.1"
                     /locus_tag="TU31_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04730"
                     /product="MFS transporter"
                     /protein_id="WP_042159708.1"
                     /transl_table=11
                     /translation="MRDRKRRGQRRASTSPWKYALATWFAGVLAAVGLGAVAPVGSALR
                     TSLGLSDGAVAWATSSITAVSAALGIPAGWWVRRFGAQRALSWGLFVMSVATVGSAAAG
                     SWGLLLGARIAEGVGYLLVFVAGPVVLTRLTQGGVRSAALALWGTCVPTGLALAAVTGG
                     ALESVWTWNQWLALTALGPLIMAGVLTAVLPRLPRAAVRCAHREAGYWNGALRLGVAYG
                     SLSLVGVAVVMVLPAFLLEERQATAAVTGAVVAVVCLGSAVGGLAASWLLRRGAALSSL
                     VPLGAVMPVACLPAFSAEFPLAVSGGAATLVLVVDGLLISAVFAAVPASVSRAEDVDVA
                     NGILNQLGSVGILLGPPVFGLVIAAAGWGTVAALTLAFGGLGAVLLLTAARTSATGSAA
                     DVSRSPDAPGGGERRNGAEPLAKAADVSKPHRTRP"
     gene            2457..3137
                     /locus_tag="TU31_RS28660"
                     /old_locus_tag="TPA0598_08_04740"
     CDS             2457..3137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601726.1"
                     /locus_tag="TU31_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04740"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_052719094.1"
                     /transl_table=11
                     /translation="MKFDFPLSRDNTYREYCLHCHAEAVTWIVVDGRKRCTCASCGREA
                     ERAVVIDPRISWWTDADGEYWHESAGVFVRDRRAKFLFFQRTAFPYRLTVPAGHVERGE
                     EPQRAAARELWEEVGIRGAHGDLRLVADEYLRGDVCRRGSDAHRWHAFLLEVDEDREAG
                     AQGELTVNEEGEAPVWLTLDQARSCRPTFAVERIIEQYSDRLLDAVPPVSDEREQGPSD
                     GARA"
     gene            complement(3181..4761)
                     /locus_tag="TU31_RS28665"
                     /old_locus_tag="TPA0598_08_04750"
     CDS             complement(3181..4761)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (111-286). E-value:
                     5.7e-15. Score: 47.5. Matches aSDomain:
                     nrpspksdomains_TU31_RS28665_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="TU31_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04750"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_078886036.1"
                     /sec_met_domain="PF00561 (E-value: 2.3e-25, bitscore: 84.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIPRRSMALSAGLLAVTTMVVTVCGAGGAAASRPGDAKGGNTSV
                     PVLPARFTQQKVQWTACGTDVTPKAVPGAQCGWVKVPVDYAAPDGKTVTLRVSRVQAKD
                     HSRRLGSLFFNPGGPGAGGAADVANGNWQAGERARARYDLVGFDPRGIAGSGQIKCPDG
                     VAEEPEDPPRTASQAEKVFADATRRARACQKASGAVLAHMDSVSVARDLDVLRTVLGDA
                     KLNYTGVSYGTFIGQQYMKLFPGKVGRMVLDGVVNPAADLRQVARLDVKTSDDAVRRYA
                     HDLVARGDDRLGATTGEILRRLTTFARELDRKPLHGAGGEEFTDADLSMYLGMAVSGEV
                     SWKRLTTALVAALRGDVTAFDRLDAEASGEGGDEESTPQEEQTEENESMSMSAVLCLDS
                     PSAPKTPEKMLATADAFAKQSPLFGRSYAWQMIDCATWPVAPTGAAEPVRATGAAPVLL
                     VSYTDDQLTPLANARAVHRQLDQSSLLVRKGEGHAAYASEPPSTCTDRAVDRYLVGGEL
                     PGEIAHCAG"
     aSDomain        complement(3904..4428)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS28665_Abhydrolase_1.1"
                     /evalue="5.70E-15"
                     /label="TU31_RS28665_Abhydrolase_1.1"
                     /locus_tag="TU31_RS28665"
                     /protein_end="286"
                     /protein_start="111"
                     /score="47.5"
                     /tool="antismash"
                     /translation="LFFNPGGPGAGGAADVANGNWQAGERARARYDLVGFDPRGIAGSG
                     QIKCPDGVAEEPEDPPRTASQAEKVFADATRRARACQKASGAVLAHMDSVSVARDLDVL
                     RTVLGDAKLNYTGVSYGTFIGQQYMKLFPGKVGRMVLDGVVNPAADLRQVARLDVKTSD
                     DAVRRYAHDLVA"
     gene            5032..5187
                     /locus_tag="TU31_RS38830"
     CDS             5032..5187
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS38830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158894762.1"
                     /transl_table=11
                     /translation="MVGHLQWSGTSSGQVAGAAELGEGGGGDQGKQVFAQDLRRVRRVV
                     APGRHQ"
     misc_feature    complement(5367..5383)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.79"
                     /tool="antismash"
     misc_feature    complement(5530..5544)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.34"
                     /tool="antismash"
     gene            <5608..5910
                     /locus_tag="TU31_RS39970"
                     /pseudo=""
     CDS             <5608..5910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991915.1"
                     /locus_tag="TU31_RS39970"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="histidine kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="SVLVTAAKQYAPLHRAPHQVTDVHELLDSTLLMVLREDRPPHHRR
                     QAGGRGHASRPGHLVAHHRQQTPGGPRFDSAPGDTRFRVRLPPAPPTPLSPQEAS"
     gene            5907..6257
                     /locus_tag="TU31_RS28670"
                     /old_locus_tag="TPA0598_08_04770"
     CDS             5907..6257
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606863.1"
                     /locus_tag="TU31_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04770"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_042159710.1"
                     /transl_table=11
                     /translation="MISPHGIDPSVPPSGTGCAECDAGGGWWFHLRRCAQCGHVGCCDD
                     SPAKHATAHARDTGHPVIRSFEPGETWFYDYDTSDVYASGPPLAPPESHPADQPTPGPA
                     GRVPADWADRLG"
     gene            6431..7570
                     /locus_tag="TU31_RS28675"
                     /old_locus_tag="TPA0598_08_04780"
     CDS             6431..7570
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058926.1"
                     /locus_tag="TU31_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04780"
                     /product="inorganic phosphate transporter"
                     /protein_id="WP_042159712.1"
                     /transl_table=11
                     /translation="MDAVSFLLVAVILTALAFDFTNGFHDTANSMATSIATGALSPRVA
                     VAVAGVLNLAGAFLSTEVAKTISGGIVENSEVSLVMIFAGLIGAILWNLVTWLLGLPSS
                     SSHALFGGLIGAVWVGAGGSAVRFGAIIEKIVIPAVASPVVACVVALLATYLAYVITRR
                     TSRRAVGKGFRAGQVGSASLVALAHGTNDAQKTMGVITLALISTGVLSHGAGPPWWVVL
                     SAGLAISLGTYAGGWRIIRTMGKQLTDIQAPQGFAAETSATAVILASSHMGFALSTTQV
                     CTGSILGAGLGRKLAHVRWGVAGRIAVSWLLTLPAAAAVGGVAAWVADQGDLGVALVAV
                     VAIAAAAAFYVLSRRHPVSPENVNEVPAPEPAPTVKPAA"
     gene            7616..7855
                     /locus_tag="TU31_RS28680"
                     /old_locus_tag="TPA0598_08_04790"
     CDS             7616..7855
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558095.1"
                     /locus_tag="TU31_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04790"
                     /product="hypothetical protein"
                     /protein_id="WP_042159714.1"
                     /transl_table=11
                     /translation="MDINWGTLAGVFAVSLGITAVVVVMFSLGLAAWARAGHGEPASHT
                     SRARHQKAAKATAVLCFASCLAVAAYGIALIVTG"
     gene            complement(7928..8293)
                     /locus_tag="TU31_RS28685"
                     /old_locus_tag="TPA0598_08_04800"
     CDS             complement(7928..8293)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_08_04800"
                     /product="hypothetical protein"
                     /protein_id="WP_158894768.1"
                     /transl_table=11
                     /translation="MRTTTGGPGPTPPTTAGAEALDGLRELQRAIGACFAGADRAVLDG
                     GLATARAAFALALATAWTALVLALAPIDDSHRAALLARRPTGIREPPRTERLTTERDTA
                     PASPSDGLPTYGALAIC"
     misc_feature    complement(8272..8286)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.26"
                     /tool="antismash"
     gene            8470..9285
                     /locus_tag="TU31_RS28690"
                     /old_locus_tag="TPA0598_08_04820"
     CDS             8470..9285
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010470403.1"
                     /locus_tag="TU31_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04820"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_042159718.1"
                     /transl_table=11
                     /translation="MSSVKSVRRRAARTTAVGALAIAACATLLTGSAAAIVNGTDSTER
                     YPFMATIPESAPDQGLYDGTCGASLIDPQWVLTAAHCVQGDGLELDGIVRIGSRHRKSG
                     GTVRAIERTVVHPGYVNGDGKAANKADIALVRLDRPVAQKPVRIAERAGQPGTPTLILG
                     FGTTVDTELRFAERLQQLNTRRSADAECAPDYADRTRLCTTSRVPKAMACFGDSGGPQL
                     QKGRHGRWELIGATSGPGTPGVACSAGPGLYSNVPAYAAWIRKTIKRNT"
     gene            9863..9973
                     /locus_tag="TU31_RS38195"
     CDS             9863..9973
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656044.1"
                     /locus_tag="TU31_RS38195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107070770.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGSFRKKTGLLNSSGNDRLVLSKN"
     gene            10001..11857
                     /locus_tag="TU31_RS28695"
                     /old_locus_tag="TPA0598_08_04830"
     CDS             10001..11857
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602539.1"
                     /locus_tag="TU31_RS28695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04830"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_042159720.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.6e-46, bitscore:
                     154.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETHPGAGRGPGDAHFAVFPDRADAAAVARCFARPQTRTLTYAS
                     GRPWLVGHWHDEDIVTARVGTDALALVGCCPVDSAELERRIGRLRDLSELDAWARSLPG
                     SFHLVAARDGQLRAQGTASGLRLVFHALVDGVRVAATSADVLADALGAEPDEEQVAVRL
                     LWPVPHPLLEAPLWREVTAVPPQDALIVAADGRSVRHSRWWTPPEPTRSLADGAPLVRD
                     ALTGAVDARTRQGGVVSCDLSGGLDSTSITFLAARSPAKVVASTWPGRDPADTDLYWAS
                     QAAGCLPQVEHVVWNADDSPLVYDDLLGIDDLLDEPTIGVMDRSRVLHHLPGLARRGSR
                     LHLTGIGGDHVAWCSEAYYHRLLRRRPLFAVRQLRGFRALWQWPLGGMARALADSRPYG
                     TWLADAARDLRGPLPASVSSGLGWGMAPRLFDWVTPEAERLAGRALRVAAANAVPLHPD
                     RGLHTDLEQIRSCTRIIRQWDRMAARAGVPMASPFFDDRVIEACLAVRPSERVTPWRYK
                     PLLTTAMRGIVPESCLGRTNKAAASMDASNGLREHRGDLLALWEDSRLERLGLVDGEAL
                     RRLAQRPATPGLRDAILYSTIAGEVWLRSLSRPARDRARTAP"
     gene            11928..12182
                     /locus_tag="TU31_RS28700"
                     /old_locus_tag="TPA0598_08_04840"
     CDS             11928..12182
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602540.1"
                     /locus_tag="TU31_RS28700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04840"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_042159722.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.6e-24,
                     bitscore: 81.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.5e-15, bitscore: 50.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALRFGDKISTAATDYGTVLLDERSGQYWELNPTAGLIVTTLLAG
                     GDETAAADALLAEFAIDRTRAEQDVATLVEELRASGLAA"
     aSDomain        11931..12176
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_TU31_RS28700_Stand_Alone_Lasso_RRE.1"
                     /evalue="7.30E-26"
                     /identifier="RREFam002.1"
                     /label="TU31_RS28700"
                     /locus_tag="TU31_RS28700"
                     /protein_end="83"
                     /protein_start="1"
                     /score="81.0"
                     /tool="antismash"
                     /translation="ALRFGDKISTAATDYGTVLLDERSGQYWELNPTAGLIVTTLLAGG
                     DETAAADALLAEFAIDRTRAEQDVATLVEELRASGLA"
     gene            12179..12613
                     /locus_tag="TU31_RS28705"
                     /old_locus_tag="TPA0598_08_04850"
     CDS             12179..12613
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602541.1"
                     /locus_tag="TU31_RS28705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04850"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_042159724.1"
                     /sec_met_domain="PF13471 (E-value: 2.3e-26, bitscore: 87.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPTGVPLARRLAARLVLLPAVVLSFLPPHRIRAVLGL
                     VRRGAAPASAGQAKAARDAMCAVSLRCAGPRGCLPRSLGAALLCRLRGSWPTWCTGVRV
                     VPPFTAHAWIEVDARPVDEGVPDDYFTRLIAVAPVSRPTR"
     gene            12610..14544
                     /locus_tag="TU31_RS28710"
                     /old_locus_tag="TPA0598_08_04860"
     CDS             12610..14544
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656040.1"
                     /locus_tag="TU31_RS28710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04860"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_042159726.1"
                     /transl_table=11
                     /translation="MTAATTKTPDRSTWGAVATMYRLTAGHRASVVVATVLTLAGSALG
                     LAQPLLARNIVDASGHGRTFWPLLALLATLFVTEAATGAVGRFVLERMGEGVVRGLRHG
                     LIARLLRLEMNQYHRHRTGDLISRVSTDTTLLRDVVSQALVDLVTGALAAAGAVVLMAW
                     IDPLLLLLVALTVATAAVVVASLLKGIRAASAHMQGSVGALAAELERALGALPMVRVHR
                     AEEREATRIGERVDAAYDAGVRTAKLASVMSPAVELAVQGSFLLVLVIGGLRVNGHANS
                     LGDLVAFLLYASYLVLPLSSVFRAVGLMQRGMGAYQRIAQALALPAEPEEVVEPAKHAE
                     AVEAVEAVEPAESVEAVERTGPGGCVVHVAPRRVERAGRGEAPALALHDVRFGYVPDRP
                     VLNGVSFTVPHHGQVALVGRSGAGKSTIFALVARFYEPDSGTLLFDGRPAAELSRGACR
                     ARIAVVDQNTHVVHGSLRDNITYAAPDAGDAEVLRVVELARLDGVVRRLPGGLSGVLGE
                     RGNTLSAGERQRVALARALLARPALLLLDEPTSHLDAINETALTTLMKEAAQECALLVI
                     AHRLSTVRHADRIIVLEEGRTVASGSHEELLTTSPSYRALAAGQMLRPAHGTSGADAAT
                     AAHGRRRTP"
     gene            complement(15334..16959)
                     /locus_tag="TU31_RS28715"
                     /old_locus_tag="TPA0598_08_04870"
     CDS             complement(15334..16959)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174246.1"
                     /locus_tag="TU31_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04870"
                     /product="ABC transporter permease"
                     /protein_id="WP_042159728.1"
                     /transl_table=11
                     /translation="MRMLFRLAVADFWDRVRRPAYAVILFAAVGLGYLATPAKEAGWVV
                     MQVGDYRGAYNSAYVGMVVALAGAVWLSLGGFYVVRNAISRDESTGVGRLLAATPLSNL
                     AYLTSKFLSSVLVLGSMLGVLAVTAVVMQLARGEATTVDPVDLLSPFVLIALPIMAFTA
                     AAALLFEAIPFLRAGLGNVLWFFIWAFIAIGGQSPNAPLGGIGVHQVVQSLGDSMKAQG
                     IDPSEAGEFSLGLTLVSKPLKTFEWTGFDPSSAYLLTRCVLILIAVALALVPAFWFPRF
                     DPARGRELQDPSAQSADDRTEDKSTFPAMPVVAIQEEPGAARSDTFGNVPRAQVKLGNS
                     AVRLLVGEVRVLLQGIPLWWWAGVLTLTAVSQMVTPATGVTRILLPLAWIWPVLIWSRL
                     GTQRHEHGVEAILGAYPAAHRRVLAEWGAGLLLTAVAGIGPALRMLTGSDGPGLLHWFL
                     GALFIPSFALALGMLSRTHRLFQAAYLPLWYGTVNGITPLDFMGALRGPDGLPAGMSPA
                     LLIGATVVMLATAFATTAARRVAG"
     gene            complement(16963..17874)
                     /locus_tag="TU31_RS28720"
                     /old_locus_tag="TPA0598_08_04880"
     CDS             complement(16963..17874)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643397.1"
                     /locus_tag="TU31_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04880"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_042159729.1"
                     /transl_table=11
                     /translation="MLELVDITKVYRGGKRAVDSMTMRLDNGMLGLLGPNGAGKSSLMR
                     IASTVTRPTSGRVLFHGTDVVAKPDVLRRALGYLPQDFGVYPNLTSREFLSYLAAAKGL
                     SARSARTRIDELLQLVNLTEAVKRPLGKYSGGMMRRVGIAQALLADPQVIIVDEPTAGL
                     DPEERVRFRNLLSDLAADRVVMLSTHIVSDVESVASDIAVVAQGRLLRRGSPEDLLAAV
                     EGWVWEVLADPGDVPALQQRHLVSRMVRTSSGVRVRLLTHVPPYATAQQVTPDLEDAYL
                     AIVGQVVGRTQEFAGLQHPEGR"
     gene            complement(17867..18301)
                     /locus_tag="TU31_RS28725"
                     /old_locus_tag="TPA0598_08_04890"
     CDS             complement(17867..18301)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090056.1"
                     /locus_tag="TU31_RS28725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04890"
                     /product="hypothetical protein"
                     /protein_id="WP_063770838.1"
                     /transl_table=11
                     /translation="MAGVVLAAGIGLTGCASAEDAKPETKNFSFGGRTLNVRSHGLPTD
                     LVAAERTDVKVTRWFDVGMGADEESSWSLKKGILDLQAKCSKIANCDVRFRVEVPKSLK
                     VLRNGRATDLKGAKNKAAGAMPAATVPVVRSWGQEARHHA"
     gene            complement(18438..18632)
                     /locus_tag="TU31_RS28730"
     CDS             complement(18438..18632)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS28730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_042159730.1"
                     /transl_table=11
                     /translation="MCPGRVELTQGGGTGLVSLRERFAVLGGALEAGAAGNGWRVAGTL
                     PIARVVRTPSAPQYGAEGL"
     gene            complement(19294..20622)
                     /locus_tag="TU31_RS28735"
                     /old_locus_tag="TPA0598_08_04910"
     CDS             complement(19294..20622)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0031167 - rRNA methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007504913.1"
                     /locus_tag="TU31_RS28735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_08_04910"
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="WP_042159731.1"
                     /sec_met_domain="PCMT (E-value: 1.6e-06, bitscore: 23.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAEPKKSLVGEEYEVEVGPVAHGGHCIARTDEGQVLFVRHALPG
                     ERVIARVTDGEEGARFLRTDAVSILEPSKDRVEAPCPFSGPGRCGGCDWQHAAPGAQRR
                     LKSAVIAEQLQRLAGLSPEDAGWDGTVEPAPGDKVAKGEVPAWRTRVQYAVDADGHAGL
                     RKHRSHDIEPVTHCMIAAPGVSELGIEKREWPQIATVEAIAATGSHDRQVILTPRPGGR
                     LPIVELDKPVSVMRVGEKDGGVHRVHGRPFVRERAADRTWRVGNGGFWQVHPKAADLLV
                     EAVMRGLMPKKGDMALDLYCGVGLFAGALAERVGDKGAVLGIESGKRAVEDARHNLQDL
                     DRVRIEHGKVDQILPRTGITDVDLIVLDPPRAGAGKNTVTHLASLTPRRIAYVACDPAA
                     LARDLKYFAEAGYAPRRMRAFDLFPMTHHVECVVVLEKAGKGA"
     misc_feature    20913..20928
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(21288..21302)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    21364..21384
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.36"
                     /tool="antismash"
     misc_feature    22336..22356
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.04"
                     /tool="antismash"
ORIGIN
        1 cgcttacctc aacagccaca ttccagtacg ccccgggcag cttcagcgcc tcgccaaggc
       61 cggacgaaag cccccctcgc cctcgtcctc ttcctcgaag cggtaaagga gttgtgcggt
      121 ggggcgcaat cacctccaca ccccacaagg cgaaaagtga gcgggtgtgc accggcgccc
      181 ggaagggtat ttttgccttt ccatttcggg cgccgcattc ccgccgtccg ttcggttcaa
      241 gcctaagaga aacgtttatt ctccgtgcgg atttaactac ttggctattg gcacatcacc
      301 tgcatattgg tctcatcggg tgtgggccaa tggaggtatg ttctcaacga acacgcatgg
      361 gtggatagtg aaagacctcc accgggttcg gagcccttgg tgtgagcagg aatggaggtc
      421 gcagatgacc atagaggaat ggctcaaaac gaatgtaacc accgacacga gggcactcgg
      481 gtggtacagc ggaccggagt gcgaggaccg tatcgtccga gcctatcgcg agctgctgag
      541 tggctatgag atcgacacct cgaagatcct caaaaccacc tgcctggtga acggcgagca
      601 caccggcgtg gtgcgtatcc aggagaacaa cttcttctcg atctgcgccc accacttcct
      661 gccgtttttc gggaaggtca acatctccta cgtgcccggt gaccgcatcc tcggactcgg
      721 caaattcccg cgtctggtac aggcgttcag ccgccgcttc cagattcagg agtatctcgt
      781 caaggacatc gctgacgaga tcatgtcctc cggcggcgca caagccgtgc gcgtcacctc
      841 cagcagtcgc cacctctgca tgtgcagtcg tggtccgtcc gaccagaccg tcaccaccga
      901 cacctcttat gtggcaggcg atcaggagtt gatggccaga ttcggcctgg acgactgatg
      961 cggactcgcg tggcgggagg tgtactcagt gatccctccc gccacgcggc cttggtcagc
     1021 ccgtccctcg acggccgacc gcgcgggacc acgcgccggc cggcacaagg agaatccgtg
     1081 cgcgacagga agaggcgcgg tcagcgccgc gcgtcgacgt cgccctggaa gtacgcgctg
     1141 gcgacctggt tcgccggcgt gctggcggca gtcggtctgg gtgccgtcgc accggtgggg
     1201 tccgccctgc gtacgtcgct cggcctgtcg gacggtgcgg tcgcatgggc cacctcaagt
     1261 atcacggcgg tgagcgccgc cctcggcatc ccggcgggat ggtgggtccg ccgcttcggt
     1321 gcccaacggg ccctttcctg gggccttttt gtcatgtcgg tggccaccgt cggcagcgcg
     1381 gccgccggct cctgggggct gctgctgggg gcacgtatcg ctgaaggggt cggctatctg
     1441 ctggtgttcg tggcgggtcc ggtcgtgctc acccgcctca ctcagggcgg cgtccggtcg
     1501 gcagcactcg cgttgtgggg cacgtgcgtt ccgacggggc tcgccctcgc cgcggtcacg
     1561 ggcggcgccc tggaatccgt gtggacatgg aaccaatggc tggccctcac cgcactcggt
     1621 ccgctgatca tggccggagt gctcacggcc gtcctgcctc ggctcccgag ggcggcggtc
     1681 cggtgtgcgc accgcgaagc cggttactgg aacggggcgt tgcggctcgg tgtggcgtac
     1741 ggcagcctgt cgctggtcgg tgtcgccgtg gtgatggtgc tgccagcgtt tctccttgag
     1801 gagcggcagg ctacggcggc ggttaccggt gccgtggtgg cggtcgtctg tctggggagc
     1861 gcggtcggtg ggctcgccgc cagttggctg ctgcggcgcg gcgcggccct ctcctcactg
     1921 gtgcccctgg gcgcggtgat gccggtcgcc tgcctccccg ccttctcggc cgaattcccc
     1981 ctcgcggtca gcggcggagc ggccacgctt gtccttgtcg tcgacggact gctgatctcc
     2041 gcggtcttcg ctgccgttcc cgcctcggtg agccgtgcgg aggatgtcga tgtcgccaat
     2101 ggcatcctca accagctcgg cagtgtgggg attctgctgg gaccaccggt cttcgggctg
     2161 gtcatcgctg ccgcggggtg gggcaccgtt gctgccctga ccctggcctt cggcgggttg
     2221 ggcgcggtcc tgctgctgac ggctgcgcgc acgtccgcga ccggttcggc ggccgacgtg
     2281 tcccggtcgc ccgacgcgcc gggtggcgga gagaggcgga acggtgcgga acccttggcg
     2341 aaggcggcgg acgtcagcaa gccgcaccgc acgcgcccct gaccgagcac ggaagtgtgg
     2401 cctgcccgac tgccgtacca gctgatggca gtccttcgcc caggaagggg cacagggtga
     2461 aattcgactt cccgctgtcg cgggacaaca cctatcgcga atactgcctg cactgccacg
     2521 ccgaggcggt cacttggatc gtcgtggacg gaagaaaacg ctgcacctgt gcttcgtgcg
     2581 ggcgcgaggc ggagagagcc gtcgtcatcg atccccgtat ctcctggtgg accgatgcgg
     2641 acggcgagta ctggcacgag agcgccgggg tgttcgtacg cgaccgtcga gcgaagttcc
     2701 tcttcttcca gcggaccgcc tttccttacc gtctgaccgt gccggcgggc catgtcgagc
     2761 gcggggagga accacagcgc gcggccgcgc gggagctgtg ggaggaagta ggaatccggg
     2821 gcgcgcacgg ggatctccgg ctcgttgcgg acgagtattt gaggggagat gtgtgcagaa
     2881 ggggttccga cgcgcatcgt tggcatgctt ttctgctgga ggtcgatgag gaccgggaag
     2941 cgggagccca gggggagctg accgtgaatg aggagggtga ggcgcccgtc tggctcactc
     3001 tcgaccaagc ccgctcctgc cggccgacgt tcgcggtgga acgcatcatc gagcagtatt
     3061 ccgacaggct gctggacgct gtcccgcctg tttctgacga gcgggaacag ggcccttcgg
     3121 acggtgcccg ggcctgacgt tttcgtccca cgccaccgcc gggggcgacc ggcgcccgtc
     3181 tcagccggcg cagtgggcga tctcgcccgg cagctctccc ccgaccagat atctgtcgac
     3241 ggcacggtcg gtgcacgtgg aggggggctc cgaggcgtac gccgcatgcc cctcgccctt
     3301 gcgcacgagg agcgagctct ggtccaactg ccggtgcacc gcccgtgcgt tcgcgagtgg
     3361 agtgagctga tcatcggtgt acgacaccag cagtaccggt gccgcgccgg ttgccctgac
     3421 cggctcggcc gcaccggtgg gggcgaccgg ccacgtcgca cagtcgatca tctgccaggc
     3481 gtaggaacgg ccgaagagcg gcgactgctt ggcgaacgcg tcggcggtgg cgagcatctt
     3541 ctccggggtc ttcggcgcgg acggggagtc caggcacagc accgccgaca tactcatgga
     3601 ctcgttttcc tcggtctgct cctcctgcgg cgtcgactcc tcgtcaccgc cctcgccgga
     3661 tgcctcggcg tccagacgat cgaaggcggt cacgtccccg cgcagggcgg ccaccagcgc
     3721 cgtggtcaac cgcttccagc tcacttcgcc tgacacggcc attcccaggt acatggacaa
     3781 gtcggcgtcg gtgaattcct cgccgccggc cccgtgcagc ggcttccggt ccagttccct
     3841 ggcgaacgtg gtgagcctcc gcaggatctc cccggtggtg gctcccagcc ggtcgtcccc
     3901 gcgcgcgacg aggtcgtggg cgtaccggcg caccgcgtca tcggaggtct tgacgtcgag
     3961 ccgggcgacc tgccgcaggt cggcggccgg attgacgacg ccgtcgagca ccatccggcc
     4021 caccttgccg gggaacagct tcatgtactg ctggccgatg aaggtgccat aggagacacc
     4081 cgtgtaattc agcttggcgt cgcccaggac cgtacgcagc acatccaggt cgcgcgcgac
     4141 gctgacgctg tccatgtgcg cgagaacggc gccgctcgcc ttttggcagg cacgggcacg
     4201 ccgggtcgcg tcggcgaaca ccttctcggc ctgcgatgcg gtacgcggcg ggtcctcggg
     4261 ttcctcggcc acaccgtcgg ggcacttgat ctgcccggac ccggctatgc ctcgtgggtc
     4321 gaagccgacc aggtcgtaac gggcccgggc ccgttccccc gcctgccagt ttccgttcgc
     4381 cacgtcggcc gcaccgccgg ctccgggtcc cccggggttg aagaacagcg accccagccg
     4441 acgactgtga tccttggcct gcacccgcga cacccgcagt gtgacggtct tcccgtccgg
     4501 ggcggcgtag tcgaccggca ccttcaccca gccgcactgc gcgccgggca cggccttggg
     4561 ggtgacatcc gtgccacagg ccgtccactg gaccttctgc tgggtgaagc gcgcgggcag
     4621 caccggaacg gacgtgttcc cgcccttggc gtcgccgggc cgggatgctg cggcgccacc
     4681 ggcaccgcag accgtcacca ccatcgtggt gacggccagc agaccggcgg acaaggccat
     4741 ggatcggcgg gggatgggca tcggcgctct cgctctctcg ctcgtcgccc gcacagcatg
     4801 cgcacaggcg ccgccgggcc gctgtagggc ccatcacagt tggggcggaa ttacgcattg
     4861 tcggcggacg aacgcatttc accctcaggt aggacggggt cacggatggc gaagtcacgg
     4921 atgaacacgt tcagcaagga gacgcaatca gtgagtcatc gccgcacggg atcgcctaca
     4981 agcgggcgat gaatgcgctg atgcaggagg cgatgtggtc gggcacctcc agtggtcggg
     5041 cacctccagt ggtcgggcac ctccagcggc caggtggccg gtgccgccga actcggcgag
     5101 ggtggcggtg gggatcaggg gaagcaggtc ttcgcgcagg atctgcggcg ggtccgccgt
     5161 gtcgtcgctc ccggccggca ccagtagtac gggaacgttg atcgcaccga cccggtccgc
     5221 gaagtcctcg accagcgcct gccgcggcca cgcccgccgg tgaggcgggc gccacgagca
     5281 ccacgcactc cctggatggc gaattgttcg acccgccacg ggggcagcac cgcgcccgtc
     5341 cccacgcccc cctgcctgga acgcactggc aagaaagtta cggtcgtaac atgggagccg
     5401 tggctcctca tcgcgccgcg gccctggtgc tgccccgcgt gctccccgtc gacctgggca
     5461 tcccgacgca aatcgacccg ggcgtgacgc gggctgtcac ccgcgatctg cggcgtcgtg
     5521 acggcgagtt gtaccgcctc gtccgcgcgg agtccggcga gtccgcgctt gccgcactgc
     5581 gtgaactgaa gctgcgtggc gccccgttcg gtacttgtca cggccgccaa gcagtacgcg
     5641 ccactccatc gggcgcccca ccaggtcacc gacgtccatg aactgctgga cagcacgctg
     5701 ctgatggttc tccgcgaaga tcggccccca catcaccgtc gtcaagccgg tgggcgaggg
     5761 cacgcgtccc ggcctggaca tctcgtggcg catcaccgcc aacaaacacc agggggaccg
     5821 cggttcgatt ccgcccccgg ggacacccgc ttccgggtac gcctgccgcc ggccccacca
     5881 accccccttt ccccacagga ggcgtcatga tttccccgca cggaatcgac ccctcggtcc
     5941 cacccagcgg aaccggatgc gccgagtgtg atgccggtgg cggctggtgg ttccatctcc
     6001 ggcgctgcgc acagtgcggc cacgtcggtt gctgcgacga ctcacccgcc aagcatgcga
     6061 cggcccatgc ccgggacacc gggcacccgg tgatccgcag cttcgaaccg ggcgagacct
     6121 ggttctacga ctacgacacc tcggacgtgt atgcctcggg cccgcccctg gctcccccgg
     6181 agagccaccc ggccgaccag ccgacccccg gccccgcggg tcgcgtcccg gcggactggg
     6241 ccgaccgtct gggataggcg gctctccccc acctacgcca tggcgctgac ctggccgagc
     6301 gccgccaccg accggccccg ccgtcgcgtt ggcggcggtc cggagcggca cttagcgtgg
     6361 gagaggacgg cggttggtac atgatccggg ggcccgtgcg gccggaccgc cctcgactcg
     6421 gaggtccggg atggacgctg tctcgttcct gctcgtggcc gtgatcctca cggcccttgc
     6481 cttcgacttc accaacggat tccacgacac cgccaactcg atggccacct ccatcgccac
     6541 cggggcgctg agcccccggg tcgccgttgc cgtcgccggg gtgctcaatc tggccggagc
     6601 cttcctctcc acggaagtgg ccaagacgat ctcgggtggc atcgtcgaga acagcgaggt
     6661 ctccctggtg atgatcttcg ccgggctgat cggggcgatc ctgtggaacc tggtcacctg
     6721 gctcctcggg ttgccgtcca gctcgtccca cgccctgttc ggcgggctga tcggcgcggt
     6781 gtgggtgggg gccgggggct ccgcggtgcg cttcggcgcg atcatcgaga agatcgtgat
     6841 cccggcggtg gcctcgccgg tggtggcctg tgtggtggcg ctgctcgcca cctacctcgc
     6901 ctacgtgatc acccggagga cctcgcgccg cgccgtcgga aagggctttc gcgcgggtca
     6961 ggtcgggtcg gcgtccctgg tggcactggc ccacggcacc aacgacgccc agaagacgat
     7021 gggcgtcatc accctcgcgc tcatctcgac cggggtactc agccatggcg cggggccgcc
     7081 ctggtgggtg gtgctgagcg cgggcctggc gatctcgctg ggcacctacg cgggcggctg
     7141 gcggatcatc cggaccatgg gcaaacagct caccgacatc caggcccccc agggcttcgc
     7201 tgccgagacc agcgccaccg cggtgatcct cgcctcgtcg cacatggggt tcgcgctgtc
     7261 gaccactcag gtgtgcaccg gcagcatcct cggcgcgggg ctgggccgca agctggcaca
     7321 tgtgcgctgg ggagtcgccg ggcggatcgc ggtgtcctgg ctgctgacac tgccggccgc
     7381 ggccgccgtg ggaggcgtgg cggcatgggt ggccgatcaa ggcgacctgg gggtggccct
     7441 ggtggcggtc gtcgccatcg ccgccgcggc ggccttctac gtgctctcgc gccgccaccc
     7501 ggtgagcccg gagaacgtca acgaggtgcc ggcacccgaa ccggccccca ccgtcaagcc
     7561 ggccgcctga gccgccccga ccggccgggc cgccgtccag gaaggggagc acgggatgga
     7621 catcaactgg ggcacactcg ccggggtctt cgccgtcagc ctcggaatca ccgccgtggt
     7681 ggtcgtgatg ttctccctcg gcctggccgc atgggcccgc gccggccacg gggagcccgc
     7741 ctcccacacc tccagagccc ggcaccagaa ggcggccaag gccacagccg ttctctgctt
     7801 cgcctcctgc ctcgcggtcg cggcgtacgg gatcgcgttg atcgtgaccg gttgaggccg
     7861 ttcggggcgc cggactcgtc cggggtgggc gagtccgcgg cggatgagtt ccaccgacca
     7921 ccacgattca gcagatcgcc agggcgccgt acgtcggcaa gccgtctgag gggctggctg
     7981 gtgccgtgtc gcgctcagtc gtcagtcgct cagttcgtgg tggttcccgg atgccggtcg
     8041 gccggcgtgc gagcagcgcg gcgcggtggg aatcgtcgat gggggcgaga gcgaggacga
     8101 gagcggtcca ggccgtggcg agggcgagtg cgaaggcggc ccgggccgtg gcgaggccgc
     8161 cgtccagcac tgctcggtcc gcgcccgcga agcaggcgcc gatcgcgcgc tggagctcgc
     8221 gcaggccatc gagggcctca gccccggcag ttgtaggcgg ggtgggcccg ggcccgcctg
     8281 ttgtggtcct caccagcagc gtgcggcggc cgtgagagct cggcaggaag ccaagtcccc
     8341 attagggggc tatccctacc gtgcatgggc cgctgcctgg accgtgttcg ggcctgctgc
     8401 ccggatggtc cggtggatct tggacacgca gactgaacac atccggttct ccaacagaag
     8461 gaactctccg tgtccagtgt gaagtcggtg cgtcgccgcg cggcgcgcac cactgccgtc
     8521 ggcgctctcg ccatcgcggc gtgcgccacc ctgctgaccg gcagcgccgc agcgatcgtc
     8581 aacgggaccg attccaccga gcgctacccg ttcatggcga cgatcccgga gtcggccccg
     8641 gatcaggggc tttacgacgg tacttgcggg gcgtcgctga tcgatccgca gtgggtgctg
     8701 acggcggccc actgtgtgca gggcgatggg cttgagctgg acggcatcgt ccggatcggc
     8761 agcaggcacc ggaagtccgg aggcaccgtc cgggccatcg agcggaccgt cgtccacccc
     8821 ggctatgtga acggcgacgg aaaggccgcg aacaaggctg acatcgcact ggtccgcctc
     8881 gaccgcccgg tcgcccagaa gcccgtccgt atcgcggagc gggccgggca gccgggcacc
     8941 ccgaccctga tcctgggttt cggcaccacc gtcgacaccg agctgaggtt cgcggagcgg
     9001 ttgcagcagc tcaacacgcg caggagcgcc gacgccgagt gcgcccccga ctacgcggac
     9061 cggacccgtt tgtgcacgac cagccgcgtg cccaaggcca tggcgtgctt cggggactcc
     9121 ggcggaccgc agctccagaa gggccggcac gggcgttggg aactgatcgg agccacctcg
     9181 ggccccggaa ccccgggcgt cgcgtgctcc gccggcccag gcctctacag caacgtgccc
     9241 gcctacgcgg cctggatccg caagaccatc aagcgcaaca cctgatcagc aacagccgcc
     9301 gaccgcatgg gggccgcccc tctcccggcc ttccaagacg cacaacatcc cgcgttcgta
     9361 cgtcgaatgc gccgacgtgg agccggacgc ccctgaggga gcaggtccct cgtcatcgcc
     9421 ttgcgtctca ccgatgaagc cgatccgtcg tcgcccggcg tgaaaggcag cggactggtt
     9481 gtgcagggag cgaggccggg cgctacccgg ctgcgaccac tccgggttcc tgcgcccccg
     9541 tgcgccgggt aagacgacgg ccaactctgc acaggcccaa aggttttttc tgaacggcgc
     9601 cggaacgcag gccctgcggt tgccgattca gtggtgcgca tctatcgagc catttcgagc
     9661 acgagtcgca cgccaattca tacaacccta tttgtggttc ttctgttgcg aggggctgcg
     9721 gggctgcaac tagcttcggt ggcgcgccgc agctcctgtt ccgggttgcc gatgaatccg
     9781 ggcgcagctg ttcatgagcc ggacggccgg ctcgtggccg ggctggggag tggcggcgta
     9841 atccgcatcg aaggagacgg caatgaagaa ggcttacgaa gcgccgacgc tcgtccgact
     9901 gggttcgttc cggaagaaga ccgggctcct gaacagctcc gggaacgacc ggctggtcct
     9961 gagcaagaac tgacggtcga cggctcgctg atccgaagcc atgactgaaa cgcacccagg
    10021 tgcgggcagg ggccccggcg acgcgcactt cgcggtcttt cccgaccgtg cggacgcggc
    10081 cgccgtggcc cgctgcttcg cccgcccgca aacccgcacc ctgacgtacg cctccggccg
    10141 tccctggctg gtgggccact ggcacgacga ggacatcgtg accgctcgcg tcggcacgga
    10201 cgccctcgcc ctcgtcggct gctgtccggt cgactccgcc gaactggagc gccggatcgg
    10261 ccggttgagg gatctctccg aactcgacgc ctgggcacgc agcctgcccg gcagcttcca
    10321 tcttgtggcc gcacgtgacg ggcagctccg ggcgcagggc accgcgtccg gtctgcggct
    10381 ggtgttccac gcgctcgtcg acggtgtgcg ggtggcggcc accagcgccg atgtgctggc
    10441 cgacgcgctg ggcgccgaac cggacgagga acaagtcgcg gtcaggctgc tgtggccggt
    10501 tccccacccg ttgctcgaag caccgctgtg gcgggaggtc accgccgtgc ccccgcagga
    10561 cgcgctgatc gtcgcggcgg acgggcggtc cgtacggcac tcgcgctggt ggacaccccc
    10621 ggagccgacc cggtcgctcg ccgacggcgc ccccctcgtc cgggacgcac tcaccggagc
    10681 cgtcgatgcc cgtacgcggc agggcggcgt ggtcagttgc gatctgtccg gcgggctgga
    10741 ctccacctcc atcaccttcc tggccgctcg gtcgcccgcc aaggtggtgg ccagtacctg
    10801 gccggggcgc gatcccgcgg acaccgacct gtactgggcc tcgcaggccg ccgggtgcct
    10861 gccgcaggtc gagcatgtgg tgtggaacgc cgacgattca ccactggtct acgacgacct
    10921 cctcggcatc gacgacctgc tggacgagcc gaccatcggc gtcatggacc gctcacgggt
    10981 gctgcaccac ctgccgggcc tggcccggcg aggcagccgg ctgcatctga ccggtatcgg
    11041 tggtgaccat gtggcgtggt gctccgaggc gtattaccac cgcctgctgc gcaggcgccc
    11101 gttgttcgcc gtgcggcagc ttcgtgggtt ccgggcgctg tggcagtggc cgctcggcgg
    11161 tatggcccgg gcgctggccg actcccggcc gtacgggaca tggctggcgg acgccgcccg
    11221 cgacctgcgc ggtccgctgc ccgcgtccgt cagcagcggt ctgggctggg gcatggcacc
    11281 gcggctgttc gactgggtca cccccgaggc cgaacggctg gccgggcggg cgcttcgtgt
    11341 tgcggccgcg aacgccgtac cgctgcatcc ggaccggggc ctgcacaccg acctggagca
    11401 gatccgctcc tgtacgcgca tcatccggca gtgggaccgg atggcggcca gggccggggt
    11461 gccgatggcg tcgccgttct tcgacgaccg ggtgatcgag gcatgcctgg cggtccgccc
    11521 gagcgagcgc gtgacgccct ggcggtacaa gcctcttctc accacggcca tgcgcggcat
    11581 cgtgccggag tcttgtctgg ggcgtaccaa caaggccgcg gcgtccatgg acgcgtccaa
    11641 cgggctgcgc gagcaccgcg gtgacctgct ggcgctctgg gaggactcac ggctggaacg
    11701 gctcggcctg gtggacggcg aggccctgcg ccggctggcc cagcggcccg ccacccccgg
    11761 gctgcgcgac gcgatcctct actcgaccat cgccggcgaa gtgtggctgc gcagcctctc
    11821 ccgcccagcg cgggacaggg cccgcaccgc cccctaggcg cttcccccag gcacttcgct
    11881 gcacgccccc atacgcccct atacgtcccc atacgaaagg cacgcatatg gcattgcggt
    11941 tcggtgacaa gatctccacg gccgcgaccg actacggcac ggtcctgctg gacgaacgca
    12001 gcggacagta ctgggagttg aaccccaccg cgggcctgat cgtcaccacc ctgctggcgg
    12061 gcggcgacga aacagcggcg gccgacgcgc tcctcgccga gttcgccatc gaccgcacgc
    12121 gcgccgagca ggacgtagcg accctggtcg aggagctgcg cgcgtcgggg ctggccgcat
    12181 gacgacaccg agtgcactgg aacggcccac cggagtcccc ctcgcccggc ggctggccgc
    12241 ccgactcgtc ctcctccccg ccgtcgtact gtccttcctg cccccgcacc gcatccgtgc
    12301 cgtactcggc ctcgtacgac gaggagccgc acccgcctct gccggccagg ccaaggctgc
    12361 ccgggacgcg atgtgcgcgg tcagcctgcg ctgcgccggg ccgcgcggct gcctgccccg
    12421 ctccctgggg gccgcgctgc tgtgccggct gcgcggcagc tggccgacct ggtgcaccgg
    12481 ggtgcgggtc gtacctccct tcacggcgca cgcctggatc gaggtcgatg cccgcccggt
    12541 ggacgaaggg gtgccggacg actacttcac ccggctcatc gccgtggcac cggtcagccg
    12601 gcccacccga tgaccgcggc caccacgaag acaccggacc gttcgacatg gggtgcggtc
    12661 gccaccatgt accggctcac cgccgggcac cgggcctccg tcgtcgtcgc caccgtgctc
    12721 accctggccg gctccgccct cggactggcc cagccactcc ttgccaggaa catcgtcgac
    12781 gccagcggac acgggcggac cttctggccg ctgctcgcgc tcctggccac gctgttcgtc
    12841 accgaggcgg cgaccggcgc ggtggggcgc ttcgtcctgg aacgcatggg tgaaggcgtc
    12901 gtacggggac tgcgccacgg cctcatcgcg cgcctgctgc ggctggagat gaaccagtac
    12961 caccggcacc gtaccggcga cctgatctcc cgtgtgtcca cggacaccac cctgctcagg
    13021 gacgtcgtgt cccaggcgct ggtcgacctg gtgaccggcg ccctggccgc cgccggggcg
    13081 gtcgtcctga tggcgtggat cgacccgctg ctgctgcttc tggtcgccct gaccgtggcc
    13141 accgccgccg tggtcgtggc ctccctcctc aaaggcatcc gggccgcctc cgcacacatg
    13201 cagggctccg tcggcgccct cgccgccgaa ctggaacgcg cgctcggcgc tttgccgatg
    13261 gtccgggtgc accgcgccga ggagcgcgag gcgacgcgca tcggcgagcg ggtcgacgcg
    13321 gcgtacgacg ccggcgtacg gaccgcgaaa ctcgcctcgg tgatgagccc cgccgtcgaa
    13381 ctcgccgtcc agggctcctt cctgctcgtt ctggtcatcg gcgggctgcg ggtcaacgga
    13441 cacgccaact ccctcggcga tctggtcgcc tttctgctgt acgcctccta cctggtgctg
    13501 ccgttgtcgt cggttttccg ggcggtcggg ctgatgcagc gcggcatggg cgcgtaccag
    13561 cggatcgcgc aggcactggc gctgccggcg gagccggagg aggtcgtgga gcccgcgaag
    13621 catgcggagg ccgttgaggc cgtggaggcc gttgagcccg cggagtccgt ggaggccgtg
    13681 gagcggaccg ggccgggcgg gtgcgtcgtc catgtggcgc cccggcgggt tgagcgggca
    13741 gggaggggcg aggcgccggc cctggccctg cacgacgtcc gattcgggta cgtcccggac
    13801 cggccggtgc tcaacggtgt ctcgttcacc gtcccgcacc acgggcaggt cgccctcgtc
    13861 ggacggtcgg gcgcgggcaa gagcacgatc ttcgcgctgg tggcgaggtt ctacgaaccg
    13921 gactccggaa cgctgctgtt cgacggtcgt cccgcagccg agctgagccg cggagcatgc
    13981 cgggcacgca tcgccgtcgt cgaccagaac acccatgtcg tccacggctc gctccgggac
    14041 aacatcacct acgcggcacc cgacgccggt gatgccgagg tcctgcgggt cgtcgaactc
    14101 gcccggctcg acggggtggt ccgacgactg cccggcggcc tgtccggcgt actcggcgaa
    14161 cgcggcaaca ccctgtcggc cggcgaaagg caacgggtcg ccctggcccg cgccctcctc
    14221 gcccggcccg cactcctcct cctcgacgaa ccgacctccc acctcgacgc catcaacgag
    14281 accgcgctca ccacgctcat gaaggaagcc gcccaggaat gcgccctcct ggtgatcgcg
    14341 caccgtctct ccaccgtccg gcatgccgac cgcatcatcg tgctggagga aggccgcacc
    14401 gtcgcctccg gctcccacga ggaactgctg accaccagtc cctcgtaccg cgcactcgcg
    14461 gccggccaaa tgctccggcc ggcccacggc acgtccggag cggatgcggc gacggccgcg
    14521 cacggacggc gccgaacgcc gtaaccgacg gccgcgtagc gctgggtggt ctggaagctc
    14581 tcgtggccga ggaagtgctg gacctcgtag agcgagactc cctgtggtga acaccacggc
    14641 gtcccggtca agccggtgga tgtggcgttc gagagcctcc aggacgtgag gtgggagcgg
    14701 gacctcccag cggctcttgg aactcttggg gtattccttg atcccgctct tggtgttgcc
    14761 ctccaccacg aacagccgcg agcggcgctg gtcgatgcga tggcggtgca ggccgggaga
    14821 gttcgcccca gcgcagtccg gtgcagaaac cgagcaggca catcgtccgc caggcggcgg
    14881 gggactcgtc gaggatgctc tgcgcctggt cgagcgtccg tcgcctcggt cacgatcgat
    14941 ggccactcgg gcatcggcgt cacccgcgga ccgtcccccc gaggcgctcc cgcatgagag
    15001 cacacttccg cgcagggcgt cgcgcgatcg ggttgtggag cgccgtcatc cggcgacggc
    15061 cttggtgtgg gtcctcagga cccgcgacac atcgaacgac tcggttccgc gggggccggc
    15121 tgcggggccg gctcagaggt tccggctgag ccggccgtaa gcccggacag tggcctcgtc
    15181 ggctcggtcg gactgctgga agcgggacat gtaatggctc acgagggagt gcaggaattc
    15241 attggccgta cgtaactact ctacctcgca acggagttcg gcgacctggc tctcagtggc
    15301 atcaatgacc cgttcgtcac ccacagcgcc ccctcaaccc gccacgcggc gggccgcggt
    15361 cgtggcgaag gccgtggcga gcatcaccac ggtggcacct atcagcagag ccggggacat
    15421 gcccgccggc aggccgtcgg ggccgcgcag ggcgcccatg aagtcgaggg gcgtgatgcc
    15481 gttgaccgtc ccgtaccaca gcggcagata cgccgcctgg aagagcctgt gggttcggct
    15541 gagcatgccc aacgccaggg cgaacgaggg gatgaacaag gcgccgagga accagtgcag
    15601 cagcccgggc ccgtccgatc ccgtgagcat ccgcagggcc ggcccgattc cggccacggc
    15661 ggtgagcaga aggcctgctc cccattccgc cagcacccgc cggtgggcgg ccggataggc
    15721 gccgaggatg gcctcgaccc cgtgctcgtg ccgctgcgta ccgagtcgtg accagatgag
    15781 cacgggccag atccaggcca gcggaagcag gatcctggtg acaccggtcg cgggtgtcac
    15841 catctgggac acggcggtga gcgtcagtac gccggcccac caccacagcg ggatgccctg
    15901 gagcaggacg cgcacctcgc cgacgagcag ccgtactgcc gagttgccca gcttgacctg
    15961 ggctcgcggt acgtttccga acgtgtcgga ccgcgcggca cccggctcct cctggatggc
    16021 cacgaccggc atggccggga acgtgctctt gtcctcggtc cggtcgtcgg cggactgtgc
    16081 cgacggatcc tggagctccc gcccgcgtgc cgggtcgaac cgggggaacc agaaggccgg
    16141 caccagggcc agcgcgacgg cgatcaggat gagcacgcag cgggtgagaa ggtatgcgga
    16201 gctcgggtcg aaccccgtcc actcgaaggt cttcagaggc ttgctgacca gggtgaggcc
    16261 gaggctgaat tcaccggcct cggagggatc gatgccctgc gccttcatgc tgtcgcccag
    16321 ggactgcacc acctggtgga caccgatccc gccgagcggc gcgttcggcg actggccacc
    16381 gatcgcgatg aaagcccaga tgaagaacca gagcacgttt cccaggcccg cccgcaggaa
    16441 cggaatggcc tcaaagagca gggcggccgc cgcggtgaac gccattatcg gcagcgcgat
    16501 caggacgaag gggctcagca gatcgacggg gtcgaccgtg gtcgcctcac cgcgggccag
    16561 ctgcatcacc actgccgtga cggcgaggac gcccagcatg gacccaagta ccaggacgct
    16621 gctcaggaac ttcgaggtca ggtaggccaa gttgctcaac ggtgtggcgg ccagaagacg
    16681 tccgacaccg gtgctctcgt cacgcgagat ggcgttgcgt acgacgtaga aaccaccgag
    16741 cgacagccac accgcgccgg ccagggccac gaccatgccg acgtaggcac tgttgtacgc
    16801 accgcggtag tcaccgacct gcatcacgac ccagccggcc tccttggccg gggtggcgag
    16861 gtagccgagg cccactgcgg cgaagaggat caccgcgtag gcggggcgcc gcacccggtc
    16921 ccagaagtcc gcgacggcga gcctgaagag catccgcatg gtctacctcc cctccgggtg
    16981 ctgcagaccg gcgaactcct gagtcctgcc gaccacttgg ccgacgatgg ccaggtaggc
    17041 gtcctccaga tcgggcgtca cctgctgcgc cgtcgcatac ggcggtacat gggtcagcag
    17101 ccgtacgcgt acgccgctgc tggtgcgtac catgcggctg accaggtgcc gctgctggag
    17161 cgcgggcaca tcgcccgggt cggccaggac ctcccacacc cagccctcca cggccgcgag
    17221 caggtcctcc ggggaaccgc ggcgcagcag gcggccctgc gccaccaccg cgatgtcgga
    17281 ggcgaccgac tcgacgtccg agacaatgtg tgtggagagc atgaccacgc ggtcggcggc
    17341 caggtcactg agcaggttgc ggaagcggac gcgctcctcg gggtcgagac cggcggtggg
    17401 ctcgtccaca atgatcactt gcggatcggc gagcagagcc tgggcgatcc cgacccggcg
    17461 catcatcccg ccggagtact tcccgagggg gcgtttgacc gcctctgtga ggttgaccag
    17521 ttggaggagt tcgtcgatgc gggtgcgtgc ggagcgggcc gagagtccct tggccgccgc
    17581 aaggtaggag aggaactccc gcgaggtgag attggggtag accccgaagt cctgcgggag
    17641 gtagccgagc gcgcggcgca gcacgtccgg cttggcgacc acgtcggtgc cgtggaagag
    17701 gaccctgccg ctggtggggc gggtgaccgt cgaggcgatc cgcatgagtg aggacttgcc
    17761 cgcgccgttg gggccgagca gaccgagcat tccgttgtcc agacgcatcg tcatgctgtc
    17821 cacggcgcgc ttgccgccgc ggtagacctt ggtgatgtcg acgagttcaa gcatggtgtc
    17881 tcgcctcctg gccccaggac cggacaaccg ggacggtggc ggccggcatg gctcccgccg
    17941 ccttgttctt cgcacccttg aggtccgtcg cacggccgtt gcgcagcacc ttcagggact
    18001 tgggcacctc cacccggaag cgcacatcac agttggcgat cttgctgcat ttggcctgga
    18061 ggtcgaggat gcccttcttc agactccagc tgctctcttc gtcggcgccc atgcccacgt
    18121 cgaaccagcg ggtcaccttg acgtccgtgc gttccgcggc gaccaggtcg gtgggaaggc
    18181 cgtgcgacct gacgttcagg gtcctgccgc cgaaggaaaa gttcttcgtc tcgggtttcg
    18241 cgtcttcggc gctggcgcat cccgtgagac cgataccggc ggcaaggacg acgcctgcca
    18301 tgacgttccg cgaccatgta cggggaacca cgattacctc cggttatgtc atcaagtggt
    18361 gtcacctaga ttcgctgtcc gggccgctcg gcacatctgc cgttcggcag agatccgtga
    18421 tccgtcttcc acggcggtca gaggccttcg gcgccgtact gcggcgccga aggcgtccgt
    18481 acgacgcggg cgatgggcag cgtgcccgcg acccgccagc cgttcccggc tgcccccgcc
    18541 tccagcgctc cacccagcac ggcgaaccgc tcgcgcaggc tgaccagtcc ggtgccgccg
    18601 ccctgcgtca gttcgacgcg acctggacac acgccacacc ggctctccca acccttctcc
    18661 cctgacaagc ctggatagcg aaagcccacc gcggactccc ggggccggcg ggcgtgggaa
    18721 cggggtggcg cccctctcct catggcaggg ttgttgagcg tcggggaacc gcgagccatg
    18781 gcaccgtccg agaatgcgac aagtggctgg ccggcccgtc gaacgcgaga tgcatcgcac
    18841 ccggatcggg ctcaccttca gccgccagga cgagaaagac gtacagcctg aggagatgtc
    18901 actcagtgcg acgtctgggg agggccacac cgtccgagcg cctcgtcgta ggcacatggc
    18961 gcctcgcgcc gcgcgaatag aggctgaccg aatcacttcg acctcaatgc cgccaatccg
    19021 cctgacgggc gccggatacc ccggcaacca cggagccgcg tccgcagagc cacacggcca
    19081 cgtcgaacgc cacccgcgta atgtgatgga ccttcaggac gagcgtcaca cgagcgtcaa
    19141 caacccgagg tgctcgctga cacgccttgt gacgccatcg ccgtgcccgc ctgaatccgc
    19201 acgtcaggcg ggtatcgcag acgcgcccgg cgcttcacct gttgggcgaa gggaaacagg
    19261 tcgagcgagc gatgagcatc acaaaaccgc aggtcaggcg cccttccccg ccttctccag
    19321 caccactaca cactccacat gatgcgtcat cggaaacaga tcaaacgccc gcatccgacg
    19381 cggcgcatag cccgcctccg cgaagtactt gaggtcgcgg gccagggccg ccgggtcgca
    19441 ggctacgtag gcgatgcggc ggggggtgag ggaggcgagg tgggtgacgg tgtttttgcc
    19501 ggcgccggcg cggggtgggt cgaggacgat gaggtcgacg tcggtgatgc cggtgcgggg
    19561 caggatctgg tcgaccttgc cgtgttcgat gcggacgcgg tcgaggtcct ggaggttgtg
    19621 gcgggcgtcc tcgacggcgc gcttgccgga ttcgatgccg aggaccgcgc ccttgtcacc
    19681 gacgcgttcg gcgagggcac cggcgaagag gccgacgccg cagtacaggt cgagggccat
    19741 atcgcccttc ttgggcatca ggccccgcat gacggcctcg accaggaggt cggcggcctt
    19801 cgggtggacc tgccagaagc cgccgttgcc gacccgccag gtgcggtcgg cggcccgttc
    19861 gcggacgaag gggcggccgt ggacgcggtg cacaccaccg tccttctctc ccacccgcat
    19921 gaccgagacc ggcttgtcga gttcgacgat ggggaggcgg ccgccggggc ggggggtgag
    19981 gatgacctgt cggtcgtggg agccggtggc ggcgatcgcc tcgacggtgg cgatctgggg
    20041 ccactcccgc ttctcgatgc cgagttcgga gacccccggg gcggcgatca tgcagtgggt
    20101 gaccggctcg atgtcgtggg agcggtgctt gcgcaggccg gcgtgaccgt cggcgtccac
    20161 cgcgtactgg acgcgggtgc gccaggccgg tacctcgccc ttggcgacct tgtcaccggg
    20221 ggcgggctcc acggtgccgt cccagccggc gtcctcgggg gagagcccgg ccaggcgctg
    20281 gagctgttcg gcgatcaccg cggacttcag gcggcgctgg gcgccggggg cggcgtgctg
    20341 ccagtcacag ccgccgcagc ggccggggcc ggagaagggg cagggggcct cgacccggtc
    20401 cttggagggc tccaggatcg agacggcgtc ggtgcgcagg aagcgggcgc cctcctcgcc
    20461 gtcggtgacg cgggcgatga cgcgctcgcc gggcagcgca tgccgtacga agaggacctg
    20521 gccctcgtcg gtgcgggcga tgcagtgacc gccgtgggcg accgggccga cctcgacctc
    20581 gtactcctcg ccgaccagcg acttcttggg ttctgcctgc atggcgggag ggctcctgag
    20641 gtgggtgtga gcggggacgg gggccggcct ccggagggag gccagccgtc aagtctacgt
    20701 cccgtgggcc gtgccccggc ccgtgcgcgg aggaccgcca ccggggcacg gaggaaagcc
    20761 cgcgctactt cttggtggcg gccttctcct tcttcggctg ggcgaccggg ccgcggcgga
    20821 ccgcacccgg agcgttccac tccgcgcgct tacgggcgcg cagcttggcg gcctcggagg
    20881 agtccagctg ccagggcacc gaggtgacca tgacgccggg agtgaagagc aggcgtccct
    20941 tgaggcgcag ggcggactgg ttgtggagca ggtgctcgta ccagtggccg acgacgtatt
    21001 cggggatgta gacggagacg gcgtcgcgcg ggctctggcg gcgcagcgac ttgacgtagt
    21061 cgatgatcgg ccgggtgatc tcgcggtacg gggaggccag gaccttcagc ggcacctcga
    21121 tgccgcggcg ttcccactcc tcccgcaggg ccctggtgtc ggcctggtcc acgtccacgc
    21181 tgaccgcttc gaggctgtcg gagcgcatca gcttggcgta gttcagggcg cgcagggtgg
    21241 gcttgtgcac cttggagacg aggacgaggg agtgcacccg ggaggggcgg accacatcgt
    21301 cgtcgggggt gtcctcggcg gcgatctcgt cggcgacccg gtcgtagtgg cggcggatcg
    21361 cggacatcgt cacgaagaag atgaccatgc cgagcagcgc gacccaggcg ccgtgggtga
    21421 acttggtcag gaggacgacc acgagcacca ggccggtgaa gaagccgccg aaggcgttga
    21481 tggcgcgcga gcggtgcata cggcggcgct tggccgggtc cttctcggtg accagatggc
    21541 ggttccagtg ccggaccatg ccgatctggc tgagcgtgaa agagacgaag acgccgacga
    21601 tgtagagctg gatgagccgg gtggagtccg cgccgtagag gtagacgagg atcgcggcgg
    21661 cgccggccag caggacgatg ccgttggaga acgccagacg gtcaccgcgg gtgtgcagct
    21721 ggcgcggcag atagcggtcc tgggcgagga tcgagccgag cagcgggaag ccgttgtagg
    21781 cggtgttggc ggccaggaac aggaccaggg cggtggcggc ggccaggatg acgaagagga
    21841 ggctgccctt gccgaagacc gcctcggcga cctgcgagat gaccgggttc tgggtgtagc
    21901 cggaaccgat cggcttgccg ttgaggagca ggtcggtggc cgggttctcg gccatcctga
    21961 cgtcggtggc catggccagg ccgatgatgc cgcagaacat ggtgacggcc aggccgccca
    22021 tcagggccag ggtggtcgcg gcgttcttgg acttcggctt gcggaaggcc ggcacaccgt
    22081 tggagatcgc ctcgacgccg gtgagcgcgg cacagccgga ggagaaggcg cgcagcatca
    22141 ggaagatcag ggcgaagccg gccaggccgc cctgttcggc gtggatgctg tagtcggcgg
    22201 tgggggcctt catggtgtcg cccatgacga cgccgcggat cacaccccag gcgatcatga
    22261 tgaagacgcc ggccacgaag acataggtcg ggatcgcgaa gagcttgccc gactccttga
    22321 cgccgcgcag gttcatcagc gtcagcagca cgatgatggc gatcgcgcac agggtcttgt
    22381 gctcgaccac gaatggaatc gcggagccca ggttctccac tccggaggag atggagaccg
    22441 cgacggtcag cacatagtcg acgagcagcg cgctggcgac ggtgagaccg gccttggggc
    22501 cgaggttggt gttggcgacc tcgtagtcgc cgccaccgct cgggtaggcg tgcacgttct
    22561 gccggtacga cgcgacgacg gtgaacatca gcaccacgac cgcgaccgcg atc
//
