LOCUS       NZ_BBNO01000007        23305 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000007
VERSION     NZ_BBNO01000007.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 900839)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 790569
            Orig. end                         :: 813874
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23305
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23305
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23305
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13305]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13305
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(89..102)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.22"
                     /tool="antismash"
     gene            294..1169
                     /locus_tag="TU31_RS25935"
                     /old_locus_tag="TPA0598_07_07020"
     CDS             294..1169
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003853.1"
                     /locus_tag="TU31_RS25935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07020"
                     /product="universal stress protein"
                     /protein_id="WP_107070745.1"
                     /transl_table=11
                     /translation="MVRPLVVGVDGSDASFLALDWAVDEAARHALPLRLVYASRWERYE
                     DTALGLSLKRPAGEVLADNIVGAAVERANLRNADVNVSTQVLGDDPESVLLRESDHVSA
                     VIVGSRGRGAFTGLLLGSVGLAVAGRAHCPVIVVRGDKAGLAGTHERVLLGVGDSAKGS
                     EAVRFAFQEAAARGCALDAVRAWRCPAHESTDHPLLPGDPERYHEGRASAVLDEALEET
                     AGEFPTVRVRRVTVEGPAHKVLLQRSAAADLLVIGAHRRDSHLGLQLGRVAHTALHHAE
                     CPVAVVPQPA"
     gene            complement(1521..2570)
                     /locus_tag="TU31_RS25940"
                     /old_locus_tag="TPA0598_07_07030"
     CDS             complement(1521..2570)
                     /NRPS_PKS="Domain: PKS_ER (26-271). E-value: 3e-09. Score:
                     28.4. Matches aSDomain:
                     nrpspksdomains_TU31_RS25940_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998361.1"
                     /locus_tag="TU31_RS25940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07030"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_042158963.1"
                     /sec_met_domain="ADH_N (E-value: 6.2e-29, bitscore: 95.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.2e-22, bitscore:
                     75.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVYHGPGQSSWDQVPDPGIKDAADAVVRVDAVTICGTDLHIL
                     KGDVPDVATGTVLGHEAVGEVVEVGGDVRTVRPGDRVLVSCICACGRCRFCKEARYGQC
                     LGGGGWVLGHLIDGAQAEYVRVPFADLSVHPLPHSVASNDAVMLADIFPTAYEVGVLNG
                     AVRPGDTVAVIGAGPIGLAAIITARLLSPARIIAVDLAEPRLQAARQLGADAIVKASEG
                     PEDLISDLTDGFGADVAIEAVGVPESFELCTRVVRPGGHIANIGVHGKPATLHLEDLWI
                     KDVTITTGLVDTCTTPVLLRMASAGRLDLSSLVTHTFPLEHMEEAYDVFSTPADSGALK
                     VVLNGPAAP"
     aSDomain        complement(1758..2492)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS25940_PKS_ER.1"
                     /evalue="3.00E-09"
                     /label="TU31_RS25940_PKS_ER.1"
                     /locus_tag="TU31_RS25940"
                     /protein_end="271"
                     /protein_start="26"
                     /score="28.4"
                     /tool="antismash"
                     /translation="DAVVRVDAVTICGTDLHILKGDVPDVATGTVLGHEAVGEVVEVGG
                     DVRTVRPGDRVLVSCICACGRCRFCKEARYGQCLGGGGWVLGHLIDGAQAEYVRVPFAD
                     LSVHPLPHSVASNDAVMLADIFPTAYEVGVLNGAVRPGDTVAVIGAGPIGLAAIITARL
                     LSPARIIAVDLAEPRLQAARQLGADAIVKASEGPEDLISDLTDGFGADVAIEAVGVPES
                     FELCTRVVRPGGHIANIGVHGKP"
     misc_feature    complement(2645..2659)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.9"
                     /tool="antismash"
     gene            complement(2729..3598)
                     /locus_tag="TU31_RS25945"
                     /old_locus_tag="TPA0598_07_07040"
     CDS             complement(2729..3598)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543305.1"
                     /locus_tag="TU31_RS25945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07040"
                     /product="universal stress protein"
                     /protein_id="WP_042158716.1"
                     /transl_table=11
                     /translation="MKDLITVGLDGTLQSLSAALWAAREAELRKARLRLLHAWILLGRE
                     PTGAPPTEAEEDHWPHRITEEAQAAVASSHPDLPVDVSLVRGDPLDALAKAAEQSDLLV
                     LGSRGLGAAARFTLGEIGLELVTRTAIPTILVRAQPDTPPSIGSGNVTVGVSLHAACDG
                     LLAFAFETASRRAVALRAVHGRHLSAYAYNRGGGVDRTAAEESAQIARDELAAALRPWR
                     AKFPDVHVDEQVILESPAPALLHGTANAELLMVGRRHRGRLLPPRIGHVVQAAVHHAPC
                     PVAIVPHD"
     gene            complement(3595..4275)
                     /locus_tag="TU31_RS25950"
                     /old_locus_tag="TPA0598_07_07050"
     CDS             complement(3595..4275)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677303.1"
                     /locus_tag="TU31_RS25950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07050"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_042158719.1"
                     /transl_table=11
                     /translation="MEHRTIGELMTRQVVSVELDTPFKDIAQILADNAVSAVPVLDSLG
                     RPAGIVSEADLLRKAADQPDLSGRTPLPHLEAWERARAEGRTAGELMSAPAVCAHPEWT
                     VVEAARLMEAQNVKRLPVVDETDVLLGIVSRSDLLRVFLRQDKAIQEEISREIIGRTAR
                     LGAAGVAADVVQGKVALHGSVDDPLLTPVLVRMCAGVDGVVSVSEDLKPAIVAGSAEGS
                     AARS"
     gene            4503..5495
                     /locus_tag="TU31_RS25955"
                     /old_locus_tag="TPA0598_07_07060"
     CDS             4503..5495
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009299297.1"
                     /locus_tag="TU31_RS25955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07060"
                     /product="nitroreductase"
                     /protein_id="WP_370682764.1"
                     /transl_table=11
                     /translation="MFTQTLDDTLVKTLVADAVMAPSMHNAQPWHFSYARGSRTFTLSA
                     DLERAMPHADPTTRALHLGCGAALLNLRVAASHAGHRTSTTLLPDPHAPACLAAVRLDD
                     PHEHMDESLPGLHPALRNRHTSRSPFTERQIPENIRATLAETAAREGAQLSFLTTPHRE
                     TVLDLIMHAEGYNRMDDGRDAEQRRWTHDTAAEPAVDDGIPDYAFGPRKRTGSAPLRDF
                     AGRGTVPDRAYADFEERPQLAALSTVGDTPADWLRAGQALERVLLLATLQGLASSFATQ
                     PVEWPDLRWILRDPQSGTGYVHMILRLGYGPMGPRTPRRSVDQVLTIKP"
     gene            6192..7007
                     /locus_tag="TU31_RS25960"
                     /old_locus_tag="TPA0598_07_07080"
     CDS             6192..7007
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-160). E-value: 5e-16. Score:
                     51.1. Matches aSDomain:
                     nrpspksdomains_TU31_RS25960_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940749.1"
                     /locus_tag="TU31_RS25960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07080"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_042158721.1"
                     /sec_met_domain="adh_short (E-value: 7e-32, bitscore:
                     106.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.3e-34, bitscore:
                     115.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEQRVVLVTGGGTGIGAATARLLRTAGHQVVISGRRPEPLRRVA
                     EETGALAHPSDAADPEAVRELVETTVTAYGRLDGVVLNAGIGRGGAVGDTAVEDWEELL
                     RTNLTGPFLLLRAALPHLLAARGAVVGVASVAALRNSVGNAAYATSKAGFLHLCRSLAV
                     DYGPQGLRANAVCPGWVRTEMADQRMARFAAEAGLAGGAEAAYEEANRLTPAGRPGDPE
                     EVAEAIDWLLSPAASYVNGAVLTVDGGVTTVGVGGAAFDYRIEARTPRL"
     CDS_motif       6207..6302
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TU31_RS25960_0001"
                     /evalue="4.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="TU31_RS25960"
                     /protein_end="37"
                     /protein_start="5"
                     /score="9.7"
                     /tool="antismash"
                     /translation="VVLVTGGGTGIGAATARLLRTAGHQVVISGRR"
     aSDomain        6207..6671
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS25960_PKS_KR.1"
                     /evalue="5.00E-16"
                     /label="TU31_RS25960_PKS_KR.1"
                     /locus_tag="TU31_RS25960"
                     /protein_end="160"
                     /protein_start="5"
                     /score="51.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLVTGGGTGIGAATARLLRTAGHQVVISGRRPEPLRRVAEETGA
                     LAHPSDAADPEAVRELVETTVTAYGRLDGVVLNAGIGRGGAVGDTAVEDWEELLRTNLT
                     GPFLLLRAALPHLLAARGAVVGVASVAALRNSVGNAAYATSKAGFLHLCRS"
     gene            7220..8422
                     /locus_tag="TU31_RS25965"
                     /old_locus_tag="TPA0598_07_07090"
     CDS             7220..8422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058172.1"
                     /locus_tag="TU31_RS25965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07090"
                     /product="DUF1266 domain-containing protein"
                     /protein_id="WP_245698714.1"
                     /transl_table=11
                     /translation="MAMWNPLAAVVQPQPSAAWQAPTENERKLYEAKARGDWVGYFDVL
                     ADCDLFISMSRWEADGPDTGPPMSYWSPVVGRWCEVVLTEGVLPAPAPDPVFGLISLGD
                     FAESWGNDERWLAVNPGTPCEAYFPPNPGLWKAHADRGKGSDVQRGTLRTLWVGAPLQG
                     PVAHGLGCGALMNVANGALWNAMGTHGNGYFLERKSLEQWWGVTDRSSWQGALDGLLKG
                     RGVRGPWEFVLEVRSSLSQQFGGQVDPALWRETAEKALLHSAAERGGTVSDAEVAGVKQ
                     LIGRITRYEGRFRADGILTANGRVRSALAWDYGRASCMARWGVGARFTDIPEAEQAVLH
                     VSRLSKMTYNSWEEFAAGYILGRCLHFDDEQFGHWYTQMLHAHQVLATRAESPWRAISW
                     A"
     misc_feature    7238..7240
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8561..9784
                     /locus_tag="TU31_RS25970"
                     /old_locus_tag="TPA0598_07_07100"
     CDS             8561..9784
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019548332.1"
                     /locus_tag="TU31_RS25970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07100"
                     /product="DUF2993 domain-containing protein"
                     /protein_id="WP_245698716.1"
                     /transl_table=11
                     /translation="MVAMLSNESSADSKARVPASRAPQDGPVSNNRGPDVPSAQGGEEP
                     DASSPQGNTAGPDSVTGTGTGSATAADSAAAATAADAGTDNTVTGDQKKHPRAARKPRR
                     IVRRTAKVVVALAVVLAFLALGDRWAVLYAENLAAQQVQKALKLRAEPEVHIDSFPLIG
                     EVLAGNIDHVEVDVPDVDAGPVSVAQVKGTVDDIRIVGSLPSSVKGAVLSRVRGDILLD
                     FKDLNREVGASQIHLMPGPEKNTVLAGGDVPVGDKQAQIRGRAQLQRTGDRGLRMTVRD
                     TRVVVPGLLTYVPGKGGGLQLTAPVADKMDKGELQQATGKRVLPQQMMKGGVLDTLVDH
                     PSLLKPTGIDPSLIQGLQKLREPKVAQKMEFSAQLPDNLPGDIRLRDISVTKNGIRAHL
                     TGKDVPVG"
     gene            complement(10001..11497)
                     /locus_tag="TU31_RS37180"
                     /old_locus_tag="TPA0598_07_07110"
     CDS             complement(10001..11497)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093192.1"
                     /locus_tag="TU31_RS37180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07110"
                     /product="DUF4334 domain-containing protein"
                     /protein_id="WP_245698720.1"
                     /sec_met_domain="T1TS (E-value: 3.4e-11, bitscore: 38.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSSRPHSHPPREIVSIADTCSAALQSMPRLEIWLKERGLPVDTA
                     LVPLMCLQTAFFTPWLPPETCYQMSRLTVWLMAVDNVLDAPDAADAPDTADSAGPDETP
                     TRVRAWHRVLAGHGSDGGSDSDDPMARALAEIARGLHRDGRPELLAVWRKSMHQTLIGM
                     QYERETARTAAAGGGVPRLADYLRHGAWTIGVEQQVTALWALMDEPGLPRRLPVLLGAL
                     REAATAIRLLNDLRGHQREQTEGKTDALAIGLTEQETYQRAEAGLENCRRALAPLTAAG
                     YGSAVALERVALWHARMYHRFDPVRPGRATTSSLPGGPGSAAQARHTPFVPQSREAPDM
                     SIEQEVLDVIASGGQCDNAKLAELFDRLEPVDTDLLLGTWQGGGFEHTSENAALLTKMR
                     WYGKRFVDADHVEPLLCRDEDGTVFSYEEMGLATLREVIYRGKQSTAMVYDQLPIIDHF
                     RRLTDNVLLCVMDKKETPTDFYFHLTRVPASLPQPSGDGR"
     gene            11773..13305
                     /locus_tag="TU31_RS25980"
                     /old_locus_tag="TPA0598_07_07120"
     CDS             11773..13305
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.4"
                     /locus_tag="TU31_RS25980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07120"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_052719050.1"
                     /sec_met_domain="T2TS (E-value: 1.5e-35, bitscore: 118.2,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRALALATRHTLSTQRDNGSWLATPDPRITETALCTLALARSPH
                     PGADRAAERGRAWLANGAVPQNHHPVAHAVETALLSLALDTGGPIDVSHPSFADRTLSA
                     RARLLQAIALYTGRATSGGTGPAALRTLLATAVAALGRLKRWTRVELWSAHALVETHFG
                     DRTSARHAARMVADQQSPSGDFFANPVTTALAALALQAAAPGTAAARRSAEYLLSSQLA
                     DGTWRFSHSDVWDTALTMRAFHGAAAFDRHGLPAAVGFLVAAQNPDGGWPYRSGVESDN
                     DTTAAVLIALGDASGAPGATIRAGLRHLVRQQTADGLWRTWQHAGDPPVDDVVAHVVTA
                     LDRHSGRHRVQLAAARGWLAERLGEQGRWHAGWYRGLPYATAEVLPALDEAVPAGGHPA
                     ARTLAETRNPDGGWPVEGSGPSTPAATGLALAALESGDLLNEELWAPALSYLVETQRDD
                     GTWPGVPLMYGPRPLLTHYPTHTHAFAVGGLIAGQRRLRTAGAATDSAHEEG"
     gene            13334..14749
                     /locus_tag="TU31_RS25985"
                     /old_locus_tag="TPA0598_07_07130"
     CDS             13334..14749
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575283.1"
                     /locus_tag="TU31_RS25985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07130"
                     /product="cytochrome P450"
                     /protein_id="WP_245698721.1"
                     /sec_met_domain="p450 (E-value: 1.3e-73, bitscore: 243.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRIGARLTGGPGRTAADAPADTPTDAGTDAPVAPGRVPLAGHAP
                     WIHRDAPGFVRELRHHGPVTKIYIGPRQVHVVNYHELVRELLTVQARAFDKGAMFDALR
                     VPLGDGLITAAGDRHLRRRRLMQPAFHHDRIAGYARIMSERSLARAAAWEPGTTLDLVP
                     EIHRLTLDILLRTLFADPQDPELRTAVKEWLSVKYHSMRLALSPLHAWAERLPLLAGWR
                     PPHAGPLRRLVAVQHRIIETYRADGRDRGDLLSMLLATGGPDDALTDAEVTDELITLFL
                     AGTGTVSASLAWALHEISRRPDVQRGIHDELDAVLAGRAPGFEDLPALVYTRQVLTEVL
                     RLHPPSWLLMRRAVRPVTLGGVRLSPGAEVFFSPYALHRDPQLYENPDDFAPERWSHDA
                     AAKAPRHTYLPFGAGSRLCIGEEFAWTELTLALAAFTAHRRLTPAGSTPVRALVGTVLR
                     PDRLPLTAHARPS"
     gene            14808..15593
                     /locus_tag="TU31_RS25990"
                     /old_locus_tag="TPA0598_07_07140"
     CDS             14808..15593
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (20-184). E-value: 7e-11. Score:
                     34.3. Matches aSDomain:
                     nrpspksdomains_TU31_RS25990_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454365.1"
                     /locus_tag="TU31_RS25990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07140"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_078885948.1"
                     /sec_met_domain="adh_short (E-value: 5.3e-35, bitscore:
                     116.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 8.8e-31, bitscore:
                     103.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHAQTSGDGPQSGRLRDRVALVTGGASGIGASCARRLAAEGAV
                     VVVADLDEDGATRVARQITAASGTALPRRIDVTDPDSVTRVVTEAATLRDGLQIAVNSA
                     GINGPLSPLAELPPADFDTVMKVNLYGVFHAMRCQLPAMAATGGVIVNLASIAAHAGFR
                     GHAAYAAAKQGVLALTRTAAREYADHGIRVVSVSPGIVDTPMVTSLPPGATDGLLTAVP
                     LRRTAQPAEVAALIAFLVSDDASYVTGSDHVVDGGYLAK"
     aSDomain        14868..15359
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS25990_PKS_KR.1"
                     /evalue="7.00E-11"
                     /label="TU31_RS25990_PKS_KR.1"
                     /locus_tag="TU31_RS25990"
                     /protein_end="184"
                     /protein_start="20"
                     /score="34.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGASGIGASCARRLAAEGAVVVVADLDEDGATRVARQITA
                     ASGTALPRRIDVTDPDSVTRVVTEAATLRDGLQIAVNSAGINGPLSPLAELPPADFDTV
                     MKVNLYGVFHAMRCQLPAMAATGGVIVNLASIAAHAGFRGHAAYAAAKQGVLALTRTAA
                     R"
     CDS_motif       14874..14951
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TU31_RS25990_0001"
                     /evalue="7.50E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="TU31_RS25990"
                     /protein_end="48"
                     /protein_start="22"
                     /score="21.8"
                     /tool="antismash"
                     /translation="LVTGGASGIGASCARRLAAEGAVVVV"
     CDS_motif       15264..15320
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TU31_RS25990_0002"
                     /evalue="2.60E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="TU31_RS25990"
                     /protein_end="171"
                     /protein_start="152"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LASIAAHAGFRGHAAYAAA"
     gene            15904..16017
                     /locus_tag="TU31_RS38145"
     CDS             15904..16017
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0043419 - urea catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012756.4"
                     /locus_tag="TU31_RS38145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="urease subunit gamma"
                     /protein_id="WP_107070747.1"
                     /transl_table=11
                     /translation="MIETVQVEATFSEGTKLVTIREKVSSLSRMTRSSVQR"
     misc_feature    16267..16282
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            16435..17409
                     /locus_tag="TU31_RS25995"
                     /old_locus_tag="TPA0598_07_07150"
     CDS             16435..17409
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS25995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_07_07150"
                     /product="hypothetical protein"
                     /protein_id="WP_042158724.1"
                     /transl_table=11
                     /translation="MSHDRTHSARTSRRTPPTGRARRAALITATALIAVPLAGAPATAW
                     AADDAPPKTPFYKTDQEVLKYLEEGNQGKRHLEDTAAIQGYPVNGRDTEEITLDQVKGK
                     GYSPEQAVQDAQKKLEGFGSTPGFENYGTEERPNSKEDKDPGWLGNWDAKSICGQSNDM
                     LAKGGKKLTCGFVGKIDQKYPVMVTTDRVPGGTKLTYVTEASVGAEDKEVKGWKVGGKL
                     TINAYPENKGPAGEVSGEYNQSTETTKKWMSLARSQREFTVPDGVEGGTFQAHANAGWY
                     IGYIVQKIDNTDGKAEKIVAIPARVLIQAPNDEVPLTWVGQGE"
     gene            complement(17598..18803)
                     /locus_tag="TU31_RS26000"
                     /old_locus_tag="TPA0598_07_07160"
     CDS             complement(17598..18803)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004947151.1"
                     /locus_tag="TU31_RS26000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07160"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_042158727.1"
                     /transl_table=11
                     /translation="MGLRVKIGLVITAAAALAAAATGVQVPGKLQDQACEVSMARLSFA
                     YRDYVQSGRALFDMKIDSTGLPAPLRNKLKDAHQATYVEDRNGTARIWAARTEDGKTFS
                     LPPFPVPTVAGLDQALWQAGAFGTAVATLGGLALATRLGRRLRHSATSATRIADGDLDV
                     RLPENGDDEIAQLTRAVNTMADALAARLEAEREVTANIAHELRTPVAGLVAAAGLLPSG
                     KPEDMVKERAGRVRDLMEDVLEVARLDGGTEQADIHTVQAGTLAQRAVRAATADRTVDV
                     SVRTIADAWVETDPRRVERVLTNLVTNALRHGQEPVVVEVDGARIAVSDHGPGFPDDLV
                     AHGPQRFRTGAQGKGLGLGLTIAVGQAQVLGAHLTFTRATDGGARAVLDLTSAVRQPPE
                     SP"
     misc_feature    18795..18808
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.71"
                     /tool="antismash"
     gene            complement(19039..19659)
                     /locus_tag="TU31_RS40650"
     CDS             complement(19039..19659)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013855.4"
                     /locus_tag="TU31_RS40650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_078885976.1"
                     /transl_table=11
                     /translation="MPAWRSSSGPGHRIPKKPGDDRPLTDSQRRIARALRQLTEQADYP
                     PSIREIADAAALSASTVAYHLPPACPGTPRDRHPRPAPKPPVAGAVSGQEPQRRLASPV
                     VSGDLSAMRPAAWPVGLRPWRGSSCAGDSPGLRERSVGVHTAQRWWRRDTLHNTCREGD
                     IPGVVFDVFDVAVALARSVVPGAGCYEASSYRGPGGGWAMPIS"
     gene            complement(19598..19807)
                     /locus_tag="TU31_RS37190"
                     /old_locus_tag="TPA0598_07_07180"
     CDS             complement(19598..19807)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836441.1"
                     /locus_tag="TU31_RS37190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07180"
                     /product="hypothetical protein"
                     /protein_id="WP_107070748.1"
                     /transl_table=11
                     /translation="MTDLSWVPRTRPAGRRGPGLINVLRRTLQRLSVRIATHPYRASLP
                     GRAPAARMALKQRTWAPDTEEARR"
     gene            complement(19804..20808)
                     /locus_tag="TU31_RS26010"
                     /old_locus_tag="TPA0598_07_07190"
     CDS             complement(19804..20808)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607549.1"
                     /locus_tag="TU31_RS26010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07190"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_042158732.1"
                     /transl_table=11
                     /translation="MLIGEVARRSGVSARMLRHYESLGLVRPSGRTGSGYREYSAEDIR
                     RIFHIESLRSLGLSLREIGRALDDPGFTPSALVDDLIRQTHERIAAETELLTRLRRIDA
                     ADPAGWEGVLQVVALLQALGSKSADARQRAALSSVDEVPVPVEALVEAALSETEPNVAG
                     ALRWALARAGDGGPALLAEGLGSPVAAVRERAVQSLAEMPGDEATARLRDALAHPDVVV
                     RGYAALALGTRGMADAIPTLIDMIVEGRNDTDAADALSVLASDTATADRIATGLVDRLA
                     HDTTKAPARGRLAQALAGIPGTTAARALVKLSHDEDRAVALTAAYLIQLRDAR"
     gene            complement(20812..21483)
                     /locus_tag="TU31_RS26015"
                     /old_locus_tag="TPA0598_07_07200"
     CDS             complement(20812..21483)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677016.1"
                     /locus_tag="TU31_RS26015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07200"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_042158735.1"
                     /transl_table=11
                     /translation="MTITRQDTDGMRALEGLEDDRSSVRLRAALAVGTTPDPRFVDKLI
                     ERCAIEPEFLVRDMLTWALTRHPVSMTLPELVREVRSERVQARSQALHTLSKIGDRQAW
                     PAITPALLCDADDEVARSAWRAAVVLVPEGEESALAAVLATQLGRGERETQLSLSRALV
                     ALGEVILPALHTATTAPGPRVRAHALATQRLLRDPDTGFEFAIDEAKRVVALGGSGQVG
                     R"
     misc_feature    21596..21612
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     gene            complement(21719..22414)
                     /locus_tag="TU31_RS26020"
                     /old_locus_tag="TPA0598_07_07220"
     CDS             complement(21719..22414)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (2-161). E-value: 2.1e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_TU31_RS26020_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058633.1"
                     /locus_tag="TU31_RS26020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_07220"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_042158972.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-24, bitscore:
                     83.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 9.8e-07, bitscore: 24.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVHGACVRDGSWWWHRTAELLQERGVPSVAPALPSCGEAGL
                     PGGAGGPGLPEDVAAVRQALLDSDEPTVVVAHSYGGIITAEAAAGVGSVRHLLLVSSYL
                     PEVGQSLSEFGDGSPAPFLDVDPEAGTFGVRPELLVDTFLQDCDPEVQAQAADHLARQS
                     VQVTGQPVGAAAWQQVPSTYLICTQDRGTPPHLQREFARRAGSVVKLDAGHHPFLSQPA
                     AVRDLLLSL"
     aSDomain        complement(21932..22408)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS26020_Abhydrolase_1.1"
                     /evalue="2.10E-10"
                     /label="TU31_RS26020_Abhydrolase_1.1"
                     /locus_tag="TU31_RS26020"
                     /protein_end="161"
                     /protein_start="2"
                     /score="32.6"
                     /tool="antismash"
                     /translation="VVFVHGACVRDGSWWWHRTAELLQERGVPSVAPALPSCGEAGLPG
                     GAGGPGLPEDVAAVRQALLDSDEPTVVVAHSYGGIITAEAAAGVGSVRHLLLVSSYLPE
                     VGQSLSEFGDGSPAPFLDVDPEAGTFGVRPELLVDTFLQDCDPEVQAQAADHLAR"
     misc_feature    complement(22589..22603)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 cctcgcagtg acccgtagcg tcctcggtgt ggtcgcacgc cgtcttcagg ccacacggct
       61 tcgtctcgcc gatatgtgcg ggcccggagc aagcagcatg ccggcaccct cgtgaaggca
      121 gccaggcgac gctctccgta catgcccggg acacggagtg cttcgacggc tgctgcaagg
      181 agagccgagc gacccacccg tcccactcca tccggccctg ctccccgacg gctgacgctg
      241 caacgatgac gtagcgggca cttcttcgct gatctgggaa ggcggtgggg acgatggtgc
      301 gccccctggt cgtcggcgtc gacggatcgg atgcgagttt cctggcgctc gactgggccg
      361 tggacgaggc tgcccgccac gcactgccgc tgcgtctggt gtatgcctcc cggtgggagc
      421 gttacgagga cacggcgctc gggctgagcc tgaagcgtcc tgccggggaa gtactcgccg
      481 acaacatcgt cggggccgcg gtcgaacgcg ccaacctgcg caacgcggac gtcaatgtct
      541 ccacacaggt cctgggggac gacccggagt ccgtgttgct gcgtgaatcc gaccatgtgt
      601 ccgcggtgat cgtcggctcg cgcggtcgcg gcgcgttcac cggcctgttg ctgggatcgg
      661 tcggactggc agtcgcaggc cgggcccatt gccccgtgat cgtcgtacgc ggagacaagg
      721 cggggctcgc agggacgcat gagcgcgtcc tgcttggcgt cggcgactcg gccaaaggct
      781 cggaagccgt ccgattcgcc ttccaggaag cagcagcccg tggctgcgcc ctcgatgccg
      841 tccgcgcctg gcgctgtccc gcgcacgaga gcaccgacca cccgctgctg cccggggatc
      901 cggagcgcta ccacgagggc cgggcatcgg ccgtgctgga cgaggcgctg gaggagacgg
      961 ccggtgagtt tccgacggtg cgggtacggc gcgtcacggt tgagggcccg gcccacaagg
     1021 tgctgctgca gcgctccgcc gccgcggatc tgctggtgat cggagcacac cgccgtgaca
     1081 gccatctggg gctccaactg gggcgtgtgg cgcacaccgc tctgcaccac gcggagtgcc
     1141 ccgtagcggt cgtgcctcag ccggcgtgaa cgcagtcaga cggtccaagg ggtcgtcacg
     1201 ggccgggacc tgaccgtacg cgggcttgcg gcgcaggcca gtgcggccac tccggtcggt
     1261 gacgggatga cgggatgacg gactatgaaa actcgcgcgt ccgaccggcg tcagtcctca
     1321 actcctcgtc ctcatgaggt ggttgccctt ggtgcatgcg agcccatgac gcgaatgcgc
     1381 cggccggtga tccgcgtcgg gtggatggcg atccattggt gacggccgtc gcccacccaa
     1441 gggcaggtgt gcgcatgctc ctccagacgg cgggacggtg tcagcggcgg tcgtggctcg
     1501 cccaggggtt gcggctgcgg tcatggggcg gcgggcccgt tcaggacgac cttgagcgcg
     1561 ccgctgtcgg ccggggtgga gaagacgtcg taggcctctt ccatatgctc aagggggaac
     1621 gtgtgggtaa ccagcgacga caggtcgagc cgtcccgctg acgccatccg cagcagcacc
     1681 ggggtcgtgc aggtgtccac gagcccggtg gtgatggtca cgtccttgat ccacagatct
     1741 tcgaggtgca gcgttgccgg ctttccatgg acgccgatgt tggcgatgtg tccgccaggg
     1801 cgtacgacgc gggtgcacag ctcgaagctc tccggcaccc ctaccgcctc gatggcgaca
     1861 tcggcaccga acccgtcggt gaggtccgaa atcaggtctt cggggccctc cgaggccttg
     1921 acgattgcgt ccgctccgag ctgacgagcc gcctgtagac ggggctcggc caggtcgacg
     1981 gcgatgatcc gggcggggga gaggagccgc gccgtgatga tggcagccag cccgatgggc
     2041 cccgcaccga tcacggcgac ggtgtcgccc ggccggacgg ccccgttcaa gacccccacc
     2101 tcataagccg tggggaagat gtcggccagc atgaccgcgt cgttgctcgc cacggaatgc
     2161 ggcaggggat ggacggacag gtcggcgaag ggaacgcgta cgtattcggc ctgggccccg
     2221 tcgatcaggt gcccgagcac ccagccgccg cctcccaggc actggccgta ccgcgcttcc
     2281 ttgcagaagc ggcagcggcc gcaggcgcag atgcacgaga ccagcacccg gtcgcccggc
     2341 cggacggtcc gtacgtcacc gccgacctcc acgacctcgc cgacggcctc gtgccccagc
     2401 accgtgcccg ttgccacgtc gggcacatcg cctttgagga tgtgcaggtc cgtgccgcag
     2461 atcgtgacgg cgtcgacgcg gacgacggcg tcggcggcgt ccttgatgcc aggatccggg
     2521 acctggtccc aggaggactg tccgggcccg tgatagacga gtgccttcat gatgcgcatc
     2581 tccctgcacg aggaaggtga gttgccttca tggccagcct cgggctgagt gcgtaggcgg
     2641 cacatgggcc ggtcggcccc gacgcggggt gcatcggccc caacaacact ccacggtgcc
     2701 tccccacggg gcgtgctgtg ccatgggatc agtcgtgagg gacgatcgct accggacacg
     2761 gggcgtggtg cacggctgcc tgtacgacgt ggccgatgcg agggggcaac aggcggccgc
     2821 ggtgccgacg gccgaccatc agcaattccg cgttcgcggt gccgtgcaga agtgccggcg
     2881 ccggactctc caatatcacc tgctcgtcga cgtgcacgtc cggaaacttc gccctccacg
     2941 ggcgcaatgc cgcagccaac tcgtctcgtg cgatctgagc cgattcctcg gcagcagtcc
     3001 ggtccactcc gccgccgcgg ttgtaggcgt acgcagacag atgtctgccg tgcacggcgc
     3061 gcagcgcgac ggcccgccgg gaggcggttt cgaaggcgaa ggccagcagg ccgtcgcagg
     3121 cggcgtgcag actgacgccg accgttacat tgccgcttcc gatactgggc ggggtgtccg
     3181 gctgggcacg gacaagaatc gtcgggatgg cggtgcgggt caccagctcc agaccgatct
     3241 ctcccagggt gaagcgtgcg gcggcgccca ggcctcgcga gccgagaacc agcaggtccg
     3301 actgttcagc cgccttggcc agggcgtcca acgggtctcc gcggaccaag ctcacgtcca
     3361 ccggaaggtc cgggtgggac gatgccaccg ctgcctgagc ctcctcggtg atccggtgcg
     3421 gccagtggtc ctcttccgct tccgtgggcg gcgcgccggt tggctcccgg ccgagcagga
     3481 tccaggcgtg cagaagccgc agccgcgcct tgcgcaactc cgcctcccgc gccgcccaca
     3541 gcgcggcgga cagggactgg agggtgccgt ccagaccgac cgtgatgagg tccttcatga
     3601 gcgtgctgcg ctcccttcgg ccgagccggc gacgatggcc ggcttcaggt cttcggagac
     3661 cgagacgacg ccgtcgacgc cggcgcacat gcggacaaga acgggggtca ggagaggatc
     3721 gtccacggag ccgtgcagtg ccaccttccc ctggacgacg tcggcggcca cgcctgccgc
     3781 gccgagacgg gcagtgcgcc cgatgatctc ccgagagatc tcctcctgga tcgccttgtc
     3841 ctggcggagg aagacgcgca gcagatcgct gcggctgacg atgcccaaca gcacgtccgt
     3901 ctcatcgacc acgggcagac gcttcacgtt ctgtgcctcc atcagccgtg ccgcctccac
     3961 cacggtccat tccggatgag cgcagacggc cggagcggac atgagctcgc cggcggtgcg
     4021 cccctcggcc cgggcccgct cccacgcctc aaggtggggc aatggtgtcc tgccggagag
     4081 atcgggctgg tcagccgcct tccgcagcag gtcggcctcg gagacgatcc cagccggcct
     4141 gccgaggctg tcgagtaccg gcacggcact caccgcgttg tccgcgagga tctgcgcgat
     4201 gtccttgaac ggcgtatcga gctcaacgct cacgacctgc ctcgtcatga gctcacctat
     4261 cgtgcggtgc tccatctccg gctcccttca ccgtggcgga ccacgcatcg ctccacttct
     4321 tcagcgtggc cggagcaggg gccgtcccgg catgagccac tcggccccat cggcccgccg
     4381 gcaggcccga aaggcccgag tggcctgagg caagggacct atggcccctg acacgaccag
     4441 atcggccccg caaggctgaa ggagcccacc gatccaccgt ccgccccgtc ctggaggccc
     4501 cggtgttcac ccagaccctc gacgacacgc tggtgaagac cctcgtcgcc gacgccgtca
     4561 tggcgccgtc catgcacaac gcccagccct ggcacttcag ctacgcccgc ggcagccgta
     4621 cgttcaccct ctccgccgac ctagagcgcg cgatgccgca cgccgacccc acgacccgag
     4681 ccctgcacct gggctgcggc gccgcgctgc tgaacctgcg agtggccgca tctcacgccg
     4741 ggcatcgcac ctcaacgacc ctcctccccg acccgcacgc cccggcgtgc ctggccgccg
     4801 tgcggctgga cgaccctcat gagcacatgg acgagtccct ccccggcctc catcccgccc
     4861 tccgcaaccg ccacaccagt cgctccccct tcacggaacg ccagatcccg gagaacatcc
     4921 gcgccactct cgccgagacc gcggcccgag aaggggcaca gctgagcttc ctcaccaccc
     4981 cgcaccgcga gaccgtgctc gacctgatca tgcatgccga gggctacaac cggatggacg
     5041 acggccgcga tgccgaacag cgccgctgga cccacgacac cgcggccgaa ccagcggtcg
     5101 acgacggcat cccggactac gccttcggac cccgcaagcg caccggctcg gcccctctca
     5161 gggacttcgc cggccggggc accgtgcccg accgcgccta cgccgacttc gaggaacgcc
     5221 cccaactggc agcgctcagc accgtgggcg acaccccggc cgactggcta cgcgccggtc
     5281 aggcgttgga gcgggtcctg ctcctggcca ccctccaagg gctcgccagc tccttcgcga
     5341 cgcagcccgt cgaatggccg gatctgcgat ggatcctgcg cgacccgcag tccggcaccg
     5401 gttatgtgca catgatcctg cgcctggggt acggcccaat gggccccagg accccgcgac
     5461 gctcggtgga tcaggtgttg acgatcaaac cgtgatgctt gccggacggg ttcagcacgt
     5521 cgattgccat gctccgggtc acacgacagc gatctcccgt ccgccgccgg ggcggtcccg
     5581 ctccacacct gaccccgccg caatctccgg cttgcctgcg cctgcgcctg ccgcctgagc
     5641 ggaaggaccc cactaccagt acctcgtccg ctagccgaac agctggctga tgccgcctcg
     5701 gccatctgct ccgctccaca tcatggcccc cacccaaaag gggaaccaac gcgcctgctc
     5761 cggcagcagt ggagcggcca ttaaccagac gagcggcagg acagcgaacg tcaggcagca
     5821 acacaagcca cgtttgccag aagcggacga gtctcgcgaa tccgtagtca tctcgtgaaa
     5881 gtaagcggtg cctacgacgc gcgcatgagt acccgtactt acggcggtca cttgcggtag
     5941 ctctgggagg tcctccgtgg tcggatctgc ggccgtggcc ggccggtgac gccgcaagcc
     6001 tccgccgtca caccgctcca tcgattcatc gccgctttgc tcgccgctgc ccttcgcccg
     6061 cggtccttcc tcgccccgca accggccgcg gtgccgacgg gagcggcacc cggtcggccc
     6121 ggcggtgccg gcgctccgta tgctcgcggc gcggggaacc ggaagctgac caccttcgga
     6181 ggcgaacgac catgtcggaa cagcgtgttg tcctggtgac gggcggggga acgggaatcg
     6241 gggccgccac cgcccggctg ctgcgcacgg ccgggcacca agtcgtgatc tccgggcggc
     6301 ggcccgagcc actgcgccgg gtggccgagg agaccggagc gctggcccac ccttccgacg
     6361 ccgccgaccc cgaggccgtg cgcgagctcg tggagacgac ggtgacggcg tacgggagac
     6421 tcgacggtgt ggtgctcaac gccggaatcg ggcggggtgg cgcggtcggc gacaccgcgg
     6481 tcgaggactg ggaagagctg ctacggacca acctcaccgg cccgttcctg ctgctgcgtg
     6541 ccgcgctgcc gcatctgctg gcggcccgtg gcgcggtggt cggggtcgcc tcggtcgccg
     6601 cgctccgcaa cagcgtcggc aacgccgcct atgcgacgtc caaggcgggt ttcctccacc
     6661 tctgccgctc cctcgccgtg gactacgggc cgcaggggct gcgggccaac gcggtgtgcc
     6721 cgggctgggt gcgtacggag atggccgacc agcggatggc gcggttcgcg gcggaggcgg
     6781 ggctcgcggg cggtgccgag gcggcatacg aggaggcgaa ccggctgact cccgccggac
     6841 ggccgggcga tccggaggag gtcgccgagg cgatcgactg gttgctgtcg ccggccgcgt
     6901 cctacgtcaa cggggccgtc ctcaccgtcg acggcggagt gaccacggtc ggcgtcggcg
     6961 gtgccgcctt cgactaccgg atcgaggcgc gcaccccgcg cctgtaacgg actatcggac
     7021 aggcctggtg acctgtccgg ctgcgcatcc ggtcacggaa cgcgtgctcc ctgccgacat
     7081 ggggctgaca tggggcggaa ggccgtgccg ctgttgagaa gcagggcgcg gccgggcgcg
     7141 cgaccagagg agccttgtcc gcattccgac gctgtcccgc tgcgttatcg ctcctgcgcg
     7201 ctttgtaagg ttcatgtcca tggcgatgtg gaacccatta gcggccgtgg tccagccgca
     7261 gccttcagcg gcctggcaag cgccgaccga gaacgagcga aagctttacg aggcaaaggc
     7321 gcgcggtgac tgggttggat acttcgatgt gctcgccgac tgcgacctct tcatctcgat
     7381 gtcccggtgg gaggccgacg ggcctgacac gggtccaccg atgtcctatt ggagcccggt
     7441 cgtcggccgg tggtgcgaag tcgtcctgac cgaaggcgtc ctgccggccc ccgcgcccga
     7501 tccggtgttc ggcctcatct ccctgggcga cttcgccgaa tcgtggggca acgatgaacg
     7561 gtggctggca gtcaacccgg gcactccgtg tgaggcgtac ttcccgccca atccggggtt
     7621 gtggaaggca catgcggacc gggggaaggg gtcggacgtg cagcgtggca ctctgcgaac
     7681 cctgtgggtg ggcgccccgc tccagggacc cgtcgcccac gggcttgggt gcggggcgct
     7741 gatgaacgtc gccaacggtg ccctgtggaa cgccatgggc acccatggca acggctactt
     7801 cctggagcgc aaaagtctgg aacagtggtg gggagtgacc gaccgaagca gctggcaagg
     7861 tgcactggac ggcctcctca aaggcagggg tgtcagaggc ccgtgggagt tcgtactgga
     7921 ggttcgcagc tccctgtccc agcagttcgg gggccaggtc gatccggcac tgtggcggga
     7981 gacggctgaa aaggcgttgc tccacagtgc tgccgaaaga ggcggtaccg tctccgacgc
     8041 cgaggtcgcc ggggtgaagc aactgatcgg ccgtatcacg cgctacgaag gccgttttcg
     8101 cgcggacggc atccttaccg ccaacggtcg cgtgcggtcc gcgctggcgt gggactacgg
     8161 acgggcttcc tgcatggccc gctggggagt cggcgcccgc ttcacggata tcccggaggc
     8221 tgaacaagcc gtattgcacg tctcacgtct gagcaagatg acctacaact cctgggagga
     8281 attcgcggcc ggctacatcc tcgggcgctg cctgcacttc gacgacgagc aattcgggca
     8341 ctggtacacg cagatgctcc acgcccatca agtgctggcc acccgcgccg aaagcccctg
     8401 gcgggccatc tcctgggcct gacacgtgta gggccacccc ccgcaacccc ctcgatccac
     8461 gcggcgctcg ggcacggcgc cgactccgac ttcggcgccc gctgcgtagg tatctcgaag
     8521 actgtgcacc acttggttcg agtgcctggg ctgtggtcgc atggtggcga tgctctccaa
     8581 cgaatcttcc gcagactcca aggcgcgggt acccgcgagc cgtgctcccc aggacggccc
     8641 ggtctcgaac aaccggggcc cggatgtgcc gtcggcccag ggcggcgaag agccggacgc
     8701 ctcgtcgccc cagggcaaca ccgccggccc cgactccgtt acaggcaccg gcaccggcag
     8761 cgccaccgcc gctgactcag ctgctgccgc aaccgcagcc gacgcaggca ctgacaacac
     8821 ggtcaccggc gaccagaaga agcacccgcg ggccgcgcgc aagccgcggc ggatcgtgcg
     8881 gagaactgcg aaggtggtcg tcgcgctggc cgtcgttctt gcgtttcttg cgctcgggga
     8941 ccggtgggcc gtgctctacg cggagaacct ggcggcgcag caggtgcaga aggcgctgaa
     9001 gctgcgcgcc gagcccgagg tgcacatcga cagcttcccg ttgatcgggg aggtgctcgc
     9061 gggcaacatc gaccatgtcg aggtcgacgt ccccgatgtc gacgccgggc cggtctccgt
     9121 cgctcaggtg aaggggacgg tggacgacat ccggatcgtc ggcagcctgc cgtcctcggt
     9181 caagggtgcg gtgctgagcc gggtgcgcgg tgacatcctg ctggatttca aggacctgaa
     9241 ccgcgaagtc ggcgcgtcac agatccactt gatgcccggc cctgagaaga acacagtgct
     9301 ggccggcggc gacgtgccgg tgggcgacaa gcaggcccag atccgggggc gcgcacagtt
     9361 gcagcgcacc ggggaccgtg gcctgcgcat gaccgtgcga gacacgcgcg tggtggtgcc
     9421 cggcctgctc acgtacgtac cgggcaaggg cggtggcttg cagctgactg cacccgtcgc
     9481 cgacaagatg gacaagggcg agctgcaaca ggcgaccggg aagcgcgtcc ttccgcagca
     9541 gatgatgaag ggcggtgtgc tggacacact cgtggaccat ccttcgctgc tcaagcccac
     9601 cggcatcgat ccctcgctca tccagggcct acagaagctc cgggagccga aggtcgcgca
     9661 gaagatggag ttctccgctc agctgccgga caacctgccg ggcgacatcc ggctgcgcga
     9721 catctccgtg accaagaacg gtattcgggc gcatctgacc ggcaaggacg taccggtggg
     9781 ctagcgggct cgtgcatggt tggcggtaag gcgtcgagtt cctgatcgtc ggccatggtc
     9841 gtgtggtggg gaacgcgtct cgtgcagcga tcatcagcga ccggaggatc agggggctgt
     9901 cggctagcgt gatcgcaccc accgcgggtg cggaccgtcc ggtcgatggc gagggcaacg
     9961 cgacaatcag tgccctcgcc caaccctggt cataggctcg ctatctgccg tcgccggatg
    10021 gctggggcag cgacgcgggt acgcgggtga ggtggaaata gaagtccgtg ggggtttcct
    10081 tcttgtccat cacacacaac aggacgttgt cggtgagccg gcggaaatgg tcgatgatgg
    10141 gcagctggtc gtagaccatc gcggtggact gcttgccgcg gtagatgacc tcgcgcaacg
    10201 ttgcgaggcc catctcctcg tacgagaaga ccgtcccgtc ctcgtcgcgg cacagcagcg
    10261 gctccacgtg atcggcgtcg acgaaccgct tgccgtacca ccgcatcttc gtcagcagcg
    10321 cggcgttctc gctggtgtgc tcgaacccgc caccctgcca ggtgccgagg aggagatcgg
    10381 tgtcgaccgg ttcgagccgg tcgaagagct ctgccagctt cgcgttgtcg cactgccctc
    10441 cggacgcgat gacgtccagg acttcctgct cgatgctcat gtccggggcc tcccttgatt
    10501 gggggacgaa cggtgtgtgg cgggcctgcg cggcgctgcc cggtccgccc ggcagggatg
    10561 aggtggtggc ccggccgggt cgtacggggt cgaaacggtg gtacatccgc gcatgccaga
    10621 gcgccacccg ctccagtgcc accgcggaac cgtacccggc cgcggtgagc ggagccagtg
    10681 cccgccggca gttttcgagc cctgcctcgg cgcgctggta cgtctcctgc tcggtcaggc
    10741 cgatggcgag tgcgtcggtc ttcccttcgg tctgttcccg ttggtggccg cgcaggtcgt
    10801 tgagcagacg gatggcggtc gcggcctcgc gcagcgcgcc gagcagcacg ggaaggcgcc
    10861 ggggcagacc tggctcgtcc atgagggccc acagggcggt gacctgttgt tcgacgccga
    10921 tggtccaggc gccgtgccga agatagtccg ccagccgggg cacgccgcca ccagccgccg
    10981 ctgtccgggc cgtctcgcgt tcgtactgca tgccgatgag cgtctgatgc atgcttttcc
    11041 gccagacggc gaggagttcg ggccggccgt cgcggtgcag accccgggcg atctccgcca
    11101 gagcgcgcgc catgggatcg tcgctgtcgc tgccgccgtc gctgccgtgc cccgcgagga
    11161 cccggtgcca ggcccggacg cgggtcgggg tctcatccgg gcccgcggag tccgctgtat
    11221 ccggtgcgtc cgctgcatcc ggtgcgtcca ggacattgtc gaccgccatc agccagaccg
    11281 tgagccggga catctggtag caggtctccg gcggcagcca aggggtgaag aacgcagtct
    11341 gaagacacat caggggaacc agtgcggtgt ccacgggcag cccgcgctct ttgagccaga
    11401 tctccagtcg cggcatgctc tgcaatgcgg cggagcatgt gtccgctatg gagacgatct
    11461 cccggggagg gtggctgtgc ggtcgcgaag agtccacacc gtcaggctac gtcccgtgct
    11521 catgcgtgtt ccggcgctcc gttgcttttc ggcacgcacc cgggccggtg cacacgccgc
    11581 agccgcgtcg cctcgcccgc ccacccggtg ggccggcagc gcgtcgggcc gtcgtccact
    11641 ccagtgagtc acgccggtga agcacgccta cgaagcggaa gcggaactcg ggaagacagg
    11701 ggttagatgt caacaggacc tgcgttaccg tccctgccgg acgcgcatct atcgcccacg
    11761 ctcgccacac gggtgagccg tgcgctggcc ctcgccaccc ggcacaccct ctccacccag
    11821 cgggacaacg gttcatggct ggccaccccc gaccctcgca tcactgagac cgcactctgc
    11881 acgctggcgc tggcgcgctc tccgcacccc ggcgccgacc gagccgccga gcggggcagg
    11941 gcgtggctcg ccaacggtgc agtcccgcag aaccaccatc cggtggccca cgccgtggag
    12001 accgcgctgc tgtccctggc cctggacacc ggcggcccca tcgacgtgag ccacccctcc
    12061 ttcgcggacc ggacgctgtc ggcccgcgcc cggctcctcc aggccatcgc tctgtacacc
    12121 ggccgagcga ccagtggcgg caccggtccc gccgcactgc gcaccctgct ggccaccgcg
    12181 gtcgcagccc tggggcggct caagcgctgg acccgggtgg aactctggtc tgcgcacgca
    12241 ctggtggaga cccacttcgg cgaccggacg tccgcccggc acgccgcccg aatggtcgcc
    12301 gaccagcaat ccccatcggg cgacttcttc gccaatcccg tcaccaccgc tctcgcggcg
    12361 ctcgcgctcc aggccgccgc ccccggcacg gccgccgccc gccgctccgc ggagtacctt
    12421 ctcagcagcc aactcgccga cgggacctgg cgcttttcgc acagcgatgt ctgggacacc
    12481 gcgctgacca tgcgcgcctt ccacggcgcg gcggccttcg accgccacgg actgccggcc
    12541 gccgtcgggt tcctggtcgc ggcacagaac ccggacggcg gctggccgta ccggtcgggc
    12601 gtcgagtccg acaatgacac caccgctgcc gtcctgatcg ctctgggcga cgcaagtggc
    12661 gcgcccggcg cgacgatccg ggccgggcta cgccacctgg tccgacagca gacggccgac
    12721 ggtctctggc ggacctggca gcacgccggg gaccctccgg tggacgacgt ggtggcgcat
    12781 gtcgtcaccg cactggaccg ccactccggc cgccatcgcg tgcaactggc agcggcgcgt
    12841 ggctggctcg ccgaacgcct cggcgaacag ggacgctggc acgccgggtg gtaccggggg
    12901 ctgccgtacg ccaccgccga ggtccttccc gccctcgacg aggcagtacc tgcgggaggc
    12961 catccggccg cccggactct ggccgaaacc cgtaatcccg atggtggttg gcccgtcgaa
    13021 gggtccggcc ccagcactcc cgccgcaacc ggactggcgc tcgcggccct ggaaagcggc
    13081 gacctgctca acgaggaact ctgggcgccg gcgctctcct accttgtgga gacccagcgc
    13141 gacgacggca cctggccggg cgtaccgctc atgtacggcc cgcgaccgct cctcacgcac
    13201 taccccaccc acacccatgc gtttgccgtc ggtggcctca ttgccgggca gcgccgtctc
    13261 cgaaccgctg gggcggccac cgactccgct cacgaggagg gctgacatgc ggccgggcac
    13321 gagaaggacc ggcatgagca gaatcggtgc acggctgacc ggcggaccgg gacgtaccgc
    13381 cgccgatgcc cccgccgata cccccactga tgccggcacc gatgcccccg ttgcccccgg
    13441 ccgagtgccg ctggccgggc acgctccgtg gatccaccgt gatgctccgg gcttcgtccg
    13501 tgagctgcgg caccacggac cggtgacgaa gatctacatc ggcccccggc aggtccacgt
    13561 cgtcaactac cacgaactcg tccgggagtt gctgaccgtg caggcccgcg ccttcgacaa
    13621 gggcgcgatg ttcgacgccc tgcgcgtgcc tctcggcgac gggctgatca ccgccgccgg
    13681 cgaccgccac ctccgccgcc gtcggctgat gcaacccgcc ttccaccacg accggatcgc
    13741 cggctacgcc cgcatcatgt ccgaacggtc cctggcacgg gccgccgcct gggaacccgg
    13801 taccactctc gacctggtgc cggagatcca ccgcctgacg ctcgacatcc tgctgcgaac
    13861 cctcttcgcg gatccccagg accccgaact gcgcaccgcc gtcaaggagt ggctgtccgt
    13921 caagtaccac tcgatgcgcc ttgccctctc cccgctgcac gcctgggcgg aacgccttcc
    13981 gctgctggcg ggatggcggc cgccgcacgc cggcccgctg cgtcggctgg tggccgtcca
    14041 gcaccgcatc atcgagacct accgtgccga cggccgggat cgcggtgatc tgctctcgat
    14101 gctcctggcc acgggcggcc cggacgatgc cctgaccgac gccgaagtga ccgacgaact
    14161 gatcaccctg ttcctggccg gtaccggcac cgtcagcgcg tcgttggcct gggcgctgca
    14221 cgagatctcc cgtcgccccg acgtccaacg gggtatccac gacgaactcg acgccgttct
    14281 cgccggacgg gcccccgggt tcgaggatct tcccgcactg gtctacacac gacaggtgct
    14341 gaccgaagtg ctgcggctgc atccgccgtc gtggctgctg atgcgccgcg cggtgcggcc
    14401 ggtcaccctc ggcggcgtac ggctctcccc gggcgccgag gtgttcttca gcccgtacgc
    14461 cctgcatcgc gatccgcaac tgtacgagaa cccggacgac ttcgctcctg agcgctggtc
    14521 gcacgacgcc gccgcgaagg cgccgcgtca cacctatctg cccttcggag cgggcagccg
    14581 gctgtgcatc ggggaggagt tcgcctggac cgaactgacc ctggcgctgg ccgcgttcac
    14641 cgctcaccgg cgcctgacac cggccggctc cacccccgtg cgggccctgg tcggcaccgt
    14701 cctgcgcccg gaccggctgc cgctcacggc ccatgcccgc ccgtcctgat ccacacggcc
    14761 tcccacacat ccctccacac gcttgccccc cttgccagga gccgcacatg ccagcacacg
    14821 cacagacgtc aggtgacgga ccgcagtccg gtcgactacg ggaccgggtc gccctggtga
    14881 ccggcggcgc ctccgggatc ggcgcctcgt gtgcgcggcg actggccgcg gaaggcgctg
    14941 tggtggtggt cgcggacctc gacgaggacg gggcgacccg cgtggcccgg cagatcaccg
    15001 cagccagtgg caccgccctg ccccgccgca tcgacgtcac cgacccggac agcgtcaccc
    15061 gcgtcgtcac ggaagccgcc accttgcgcg acggcctgca gatcgcggtc aacagcgccg
    15121 gaatcaacgg ccccctcagt ccactggccg aactcccgcc cgccgacttc gacaccgtga
    15181 tgaaggtgaa tctgtacggc gtcttccacg cgatgcgctg tcagctcccc gcgatggccg
    15241 ccacgggtgg cgtcatcgtc aaccttgcct ccatagcagc acatgcgggc ttccgagggc
    15301 acgccgccta cgcagccgcc aagcagggtg tcctcgccct gacccggacc gcggcgcgcg
    15361 aatacgccga ccacggcatc cgggtcgtgt cggtatcacc aggcatcgtc gacaccccta
    15421 tggtcacctc gctgccgccc ggagccaccg acggcctcct caccgccgtc cccctgcggc
    15481 gcaccgcgca gccggccgaa gtcgccgcac tcattgcgtt cctggtgtcc gacgacgctt
    15541 cgtacgtgac gggcagcgac catgtcgtcg acggcggcta cctggccaag tagccgaccg
    15601 gaacacttgc gggaagatcc gcggcagctg ggcagctggg cagccgggcg cggcctgtgc
    15661 ccttccgcgt tatcgcgacc tggtacgtca cggcactgcc cctcccaact gccggggtct
    15721 gcccggacgg ttcggtcgcc gtgggaacgg aggcaggcca tggaggcttc gccccggctg
    15781 ccgggcaagg ccaggtccca gcgcaacagc ccaggacaga agtcctcggc aggggcgaac
    15841 gcagggaacg gtgcacctga ctccgcatga gcaagagcgc tcagtgatgg aggagttccc
    15901 gaaatgatcg agaccgtgca ggtggaggcc acgttctccg aggggacgaa gctggtcaca
    15961 atccgggaaa aggtctcctc cctctcgcga atgacacgct cctctgtcca aaggtagagc
    16021 cgcagcccga gacggtcttg agtcgctcgc ggcatctttc tgctggtcaa ggcccctccg
    16081 ccggaattcc cccgtctgca ctgccacctg cgctcggaaa accgccggga aaggcaatac
    16141 ctgaggcgta ggccacccga tagatacgga ttcgctcccc tcagatacgg gttcgctccc
    16201 ctcgcgttcg cctcactctg agttgactgg gagatgcgcg ggcaagtcgc tcaatgggga
    16261 ccatgcgtca actcatggaa acttgcggaa gttaccgggg agtccgggga acccatagtg
    16321 agcagcggcg ctctccctaa atgccaaagg gcggaaacct ccgtgccgca atcttcaggc
    16381 gagttcggga acaggctgat gcatcagcca cccggcacaa ggaaggaaaa agagatgtca
    16441 cacgacagga cacactcggc ccgcacttcc cgccgcacgc caccgacagg gagagcccgg
    16501 cgtgccgccc tcatcaccgc gaccgcactc atcgcggtcc cgctcgctgg tgctcccgct
    16561 acggcctggg ccgccgacga cgcgcccccc aagaccccct tctacaagac cgaccaggag
    16621 gtcctcaagt acctcgaaga gggaaaccag ggaaagcggc acctcgaaga cacggcagcc
    16681 atccagggct acccggtcaa cggtcgggac accgaggaga tcacgctcga tcaggtgaag
    16741 gggaaggggt attcacccga gcaggcggtc caggatgccc aaaagaagct ggagggcttc
    16801 ggttccaccc ctggtttcga aaattacggc acggaagaac gcccgaacag taaggaggac
    16861 aaggatcctg gctggctggg taactgggat gcgaagtcca tatgcggcca gtccaacgac
    16921 atgctcgcga agggaggcaa gaagctgacg tgtggctttg tgggaaagat cgaccagaag
    16981 tacccggtga tggtgaccac ggacagggtt cccggtggga cgaagctcac ctacgtgacc
    17041 gaggccagcg tcggcgcgga agacaaagag gtcaagggct ggaaggtggg cggcaagctc
    17101 accatcaacg cctacccgga aaacaagggg cccgctggcg aagtctccgg cgagtacaac
    17161 cagtcgaccg aaaccacgaa gaagtggatg agcctggcca ggagccaaag ggaattcacc
    17221 gtcccggacg gagtggaggg cggaacgttc caggcgcacg cgaacgccgg gtggtacatc
    17281 ggatacatcg tccaaaagat cgacaacacc gatggaaagg cggaaaagat cgtcgcgatt
    17341 cccgcacgtg tgctcatcca ggcgccgaac gacgaagttc cccttacgtg ggtcgggcaa
    17401 ggagagtagg gcctgatcgg tagcggctgg tcacgagtcg gatgttcttg ctgtggctgg
    17461 tgtgatcacg gcgtcggagc cgtcctggac agcccgctca cccgggctga gcccgcggta
    17521 gttcggcaga ttgatccccg ccttgcgctg cgaagcgctc ggggaggatg gtccttctgt
    17581 ggggctcggg ggccggttta cgggctctcg ggtggctggc gtacggcgct ggtcaggtcg
    17641 aggaccgccc gcgcaccgcc gtcggtcgca cgggtgaagg tcaggtgtgc gcccaggact
    17701 tgggcctggc ccaccgcgat ggtcaacccc agtccgagtc ccttgccctg cgcgccggta
    17761 cggaaccgct gagggccgtg ggcgaccaag tcgtcgggga agccggggcc gtggtcggat
    17821 accgcgatcc gtgccccgtc cacctccacc acgacgggtt cctgtccgtg gcgcagggcg
    17881 ttggtgacca ggttggtcag gacgcgttcc actcgccggg ggtcggtttc cacccacgcg
    17941 tccgcgatgg tccgtaccga tacgtccacg gtgcggtcgg cggtcgcggc acgtaccgct
    18001 cgctgggcca gcgtccctgc ttgcacggtg tggatgtcgg cctgttcggt cccgccgtcc
    18061 agccgggcga cttccaggac gtcttccatc aaatctctga cacggccggc gcgttctttg
    18121 accatgtcct cgggcttgcc ggaggggagg aggccggcgg cggcgaccag gccggcaacg
    18181 ggggtgcgca gttcgtgagc gatgttcgcg gtcacctcgc gttcggcctc aaggcgtgcg
    18241 gcaagggcgt cggccatggt gttgaccgcc cgggtgagct gggcgatttc gtcgtcgccg
    18301 ttctcgggca gtcgtacgtc caggtcgccg tcggcgatcc gggtggcact ggtggccgag
    18361 tgcctcaggc ggcggcccag gcgggtggcc agggccaggc cacccagcgt ggcgactgcg
    18421 gtcccgaagg cgcctgcctg ccacagcgct tggtccaagc cggcaacagt ggggaccgga
    18481 aaggggggca gcgagaaggt cttcccgtct tctgtgcgcg ctgcccagat ccgcgcggtg
    18541 ccgttgcggt cctccacata ggtggcctga tgcgcatcct tgagcttgtt gcgcaggggg
    18601 gcgggcaggc cagtggagtc gatcttcatg tcaaacagtg cccggccgga ttgcacgtaa
    18661 tcgcggtagg cgaaggagag gcgagccatc gacacttcgc aggcttgatc ctgcagcttt
    18721 cccggcacct gcaccccggt ggcggccgcc gcgagcgccg cagcggccgt aatgaccaaa
    18781 cctatcttga cacgcaaacc catgcttgcc cctctgtaca caatctcccg ccggagggcc
    18841 agcgccccgc gtaccgggcc attccgccgc cgaggacgcc ctctcgatgc tgcgcaccat
    18901 cgtcagcgaa tgggcagcgc aggccgagga gggagagacg gtgtgggcac cgcccggtgg
    18961 ccgggagatg acgccggacc gaggcacact gtccgtgccg gcgggcatac cgacctccca
    19021 gggagacaac ctcgacgttc agcttattgg catggcccag cccccgccgg gaccgcggta
    19081 cgaggaagcc tcgtagcagc ctgccccggg gacgaccgac cgagccagag ccactgccac
    19141 gtcgaagacg tcgaagacga cgccggggat gtccccttca cgacaggtgt tgtgcagggt
    19201 gtcgcgcctc caccacctct gagctgtgtg aactccaacc gaacgctcgc ggagcccggg
    19261 agaatctcct gcgcaagagc tgccgcgcca cggtcgaagc ccgacgggcc aagccgccgg
    19321 ccgcatagcc gacaggtcgc cggacacgac cgggctcgcg agtctccgct ggggttcctg
    19381 gccgctcacc gcacctgcca cgggcggctt cggtgcgggg cgtgggtggc gatcccgggg
    19441 cgttccaggg catgcaggtg gcaggtggta ggcgactgtc gaggcggaca gggcggccgc
    19501 gtcggcgatc tcccgtatcg acggcgggta gtcggcttgt tcggtcagct gccgcagggc
    19561 ccgggcgatc cggcgctggc tgtcggtgag ggggcggtca tcgccgggct tcttcggtat
    19621 ccggtgccca ggtccgctgc ttgagcgcca tgcgggcagc tggtgcccgg ccggggaggc
    19681 tcgcccggta cgggtgcgtg gcgatccgta cggacagccg ctgcaaggtg cggcgcagga
    19741 cgttgatcag tccgggcccc cgccgtcccg cgggccgcgt acgcggcacc caggagaggt
    19801 ccgtcaccgg gcatcgcgta gctgaatgag gtacgccgca gtaagcgcaa cggcacggtc
    19861 ctcgtcatgc gacagcttca cgagggcacg tgcggctgtg gtccccggga ttcccgccag
    19921 cgcctgggcc agccgtccgc gtgcaggcgc cttggtggtg tcgtgggcga ggcggtcgac
    19981 gagcccggtc gcgatccgat ccgccgtcgc ggtgtcgctc gccagcacgc tcagtgcatc
    20041 ggctgcgtcg gtgtcgttcc ttccctccac gatcatgtcg atgagcgtcg ggatcgcatc
    20101 ggccattccg cgtgtcccga gcgccagagc cgcatagccg cggaccacga cgtcggggtg
    20161 tgcgagagcg tcccgcagcc gggcggtggc ctcgtcgccg ggcatttcgg cgagggactg
    20221 aacggcacgt tcccgcaccg cggccaccgg tgagccgagg ccctccgcca gcagtgccgg
    20281 gccgccgtcg ccggctcgcg ccagcgccca tcgaagggct cctgcgacgt tcggctccgt
    20341 ctcgctcagt gccgcctcga ccagggcctc caccggcacc ggaacctcgt cgaccgagga
    20401 aagggccgcg cgctggcgtg cgtcggcgct cttcgacccc agtgcctgga ggagcgcgac
    20461 gacctggagg acgccctccc agccggcggg gtctgcggca tcgatccggc gcagccgcgt
    20521 gagcagctcg gtctccgccg cgatgcgttc gtgcgtctga cggatgaggt cgtcgacgag
    20581 tgccgagggc gtgaagccgg gatcgtccag cgcgcgcccg atctcgcgca gcgacagccc
    20641 cagcgaccgc aggctctcga tatggaagat ccgccggatg tcctccgcgg agtactcccg
    20701 ataaccggag cccgtacgac ccgaaggccg caccaggccg agcgactcgt agtgccggag
    20761 catgcgggca ctgaccccgg accgccgcgc cacctcaccg atcaacacgt cctaccgtcc
    20821 cacctggccg gacccgccga gggccacgac gcgcttcgcc tcgtcgatcg cgaactcgaa
    20881 tccggtgtcc gggtcgcgca gcagccgttg tgtggcgagc gcgtgcgcgc gcacgcgcgg
    20941 tccgggtgcc gtcgtcgcag tatgcagtgc cggcagaatc acttcaccca gcgcgaccag
    21001 cgcgcggctg agactcagct gagtctcccg ctcaccgcgc ccgagctgcg tcgccagcac
    21061 cgcggccaag gcggattcct cgccttccgg cacgagcacg accgcggccc gccaagcgct
    21121 ccgcgccacc tcgtcgtcgg cgtcgcacaa cagcgccggt gtgatcgccg gccaggcctg
    21181 ccggtccccg atcttggaca gcgtgtgcag cgcctggctc cgtgcctgca cacgctccga
    21241 gcggacttcg cggaccagct cggggagcgt catggacacc gggtggcggg tgagcgccca
    21301 ggtcagcatg tcccggacca agaactccgg ctcgatcgca caccgctcga tgagcttgtc
    21361 gacgaagcgc gggtcaggcg tcgtgccgac cgccagagca gcccgcagtc gcacggacga
    21421 acggtcgtcc tccaacccct caagcgctcg catcccatcg gtgtcctgtc gcgtgatcgt
    21481 cattgagacc acctcctcgg caagcagtga agaccctgac accgtgtcaa ggtcaaacac
    21541 ggcccgccgc acgatcaccg gtcacacgct gcgtcccgtt cccgaccgca gacggatacc
    21601 ccgacggcgg atcgccgtcc gcacggtaaa caaggaacgg ggggcggcct ttgccggcga
    21661 cgtgatgctg gccggccctc ggaccgagtc aagggctgcc ggtagcttcc cgctgccgtc
    21721 acaggctcag cagcaggtcc cggaccgcag caggctggga caggaacggg tggtggccgg
    21781 cgtcgagttt gacgacgctg ccggcccggc gggcgaactc gcgctgtagg tgcggcgggg
    21841 tgccgcggtc ctgggtgcag atgaggtacg tcgagggcac ctgctgccat gcggccgccc
    21901 cgaccggctg cccggtcacc tgcacgctct ggcgggcgag gtggtccgca gcctgcgcct
    21961 ggacctcggg gtcgcagtcc tggaggaacg tgtccacgag cagctcgggg cggaccccga
    22021 aggtgccggc ctcggggtcg acgtcgagga acggggcggg gctgccgtcc ccgaactccg
    22081 acaggctctg cccgacctcg ggcaggtagc tggagaccag cagcaggtgg cgcaccgacc
    22141 cgacgcccgc tgcggcttcc gcggtgatga tgccgccgta gctgtgggcg actacaacgg
    22201 tcggctcgtc gctgtccagc agtgcctgcc gcaccgccgc gacgtcctcg ggcagccccg
    22261 gaccgccggc gcccccgggc aggcccgcct cgccgcagct cggcagcgcc ggggccacgc
    22321 tcggcacccc tcgctcctgc aacagctcgg cggtgcggtg ccaccaccac gacccgtccc
    22381 gtacgcacgc accgtgcacg aacacgaccc tcatcgccat ctccaagtcg gtctcgactg
    22441 cccccaggcc ggcttcccga tcatcatggc ccgggtctcg tctcggtagg cccaggtggg
    22501 gaatagcctt gagtctccag tgactggaga cagcagagtg ggggacatgg acgttacgac
    22561 cctctactcg atcggggagc tttcccggcg gaccggcttg tccgtgagga ccatccggtt
    22621 ctactccgat tcgggggtgg tagcgccgac cacccgaagt cccgccggct atcggctcta
    22681 cgacctcgac gcactgcttc gtctggaact cctccgcaca ctacgcgagc tgggtatgaa
    22741 cctggccacg attcaacggg tactggatcg cgagctctcc gtggcggaag tcgccgcggc
    22801 gcacgccgat gccatagacg tccagatccg ggtgctgcaa ctgcgtaaga gcgttctgcg
    22861 agcggtggcc agacgcgggg ccagtcccga ggagaccaag ctcatgcaca ggctcacgca
    22921 gttgtccggc gcggaacgcc gacggttgat cgacgatttc gtggagggca cgttcggcac
    22981 cgtggatgcc gacccggcgg cggtggccat ggttcgcgct gccactccag acctccccgg
    23041 tgatccgtcc agcgagcagg tcgccgcgtg ggtggaactc gctgagctgg tcggcgacga
    23101 ggacttccgg gcgcggatgc gccggacggc caggtggcag gccgccgggc gcaggctcga
    23161 catcgagagc ggtgccggag aggaactgat ggagctcacc cgccggaagg tggccgcggc
    23221 catggagtcg ggcatcgatc cgctcagcga cagggccgca cccgtcattg acgacctcat
    23281 acaccgcttc gccgaggtgt tcgcg
//
