LOCUS       NZ_BBNO01000007        28416 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000007
VERSION     NZ_BBNO01000007.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 900839)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 585168
            Orig. end                         :: 613584
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28416
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..28416
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28416
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:18416]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18416
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(75..89)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(172..1542)
                     /locus_tag="TU31_RS25090"
                     /old_locus_tag="TPA0598_07_05180"
     CDS             complement(172..1542)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004985436.1"
                     /locus_tag="TU31_RS25090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05180"
                     /product="sensor histidine kinase"
                     /protein_id="WP_042158427.1"
                     /transl_table=11
                     /translation="MHRVSQGGWKSRGPRLWAAVRGIPHTLRADLWTVARDPLPRLRWL
                     GRLPHAHVVLAAVLMGWLNAVQGEGDFGPAVMTSVLVLAALQSGAVVLALSRPVPAWWL
                     STIALFLARNVGSLKVSHAPLWSWSIPGISLHALVLFLLALRVRPRIAAEALGFSLLAA
                     VAALVFVTPAPEPTLPGAAAPVLQTSAQDVTVVQDVVTFTLAVVVGTSLRGRRVARTQL
                     VEQEVLTAGERARRTLLEERNRIARELHDVVAHHMSVISIQAQVAPHLVKDPTDELKEN
                     LAGIRGSAVEALTELRRVLGVLRSEEALADGVRHTPQPTLGRLDELVGTVRGAGLRVTT
                     EITGEVRPLSPGVELSAFRIVQEALSNALRHAPGAKVRVALGYRSGGLTIRVANTAPDR
                     PAPPSPGAGHGLLGMHERTAMLGGELATGPTPDGGYEVTAILPTQAAQPADPREPAP"
     gene            complement(1544..2704)
                     /locus_tag="TU31_RS25095"
                     /old_locus_tag="TPA0598_07_05190"
     CDS             complement(1544..2704)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145924.1"
                     /locus_tag="TU31_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05190"
                     /product="acyltransferase"
                     /protein_id="WP_042158429.1"
                     /transl_table=11
                     /translation="MRELIRRIAAATPADRDRGVDALRALAILGVMLGHWLVTALVADS
                     GTVRVVSPLHQLPYLTPVSWLLQTLAVFFLVGGQMAATSHAATRARGGTYRRWLGARTA
                     RLFRPVVAMLAVWSVVAGALLVAGAGLDTVWTLGKLALSPLWFLLVFAALTAATPLVAR
                     LHPLWPLAVVLHIDLIRFGLGGPAWLGWTNVAAGWLVPYCLGAAWARGGLRGRATAWVL
                     LLGGAATTAGLVLWAGYPAAMVGVPGAGISNLNPPTLAAVTFGLAQCGAALLLLGPLRR
                     LLQRPAVRAAVALLNLSAMTLFLWHQTAMMAVTAVGLLTGGFLPGLHTLPDGAGWVLAR
                     LVWLPVFALALMVCWAAFRTYEQGRRRGATVVRAGRPAEARAVRRA"
     gene            complement(2697..3665)
                     /locus_tag="TU31_RS25100"
                     /old_locus_tag="TPA0598_07_05200"
     CDS             complement(2697..3665)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091926.1"
                     /locus_tag="TU31_RS25100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05200"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_042158431.1"
                     /transl_table=11
                     /translation="MASRPRGSRPLRTLLAAFVVTSVVVPVSGAARPAAVPAPAPKALA
                     PLRSATPGALAERYAVNRAGIRAAERMAEGHGDRARAEALRGMAGPARQFLFFDGRNGG
                     RTTEVFGDLARAERIAVLVPGSDTHLDRYARLRSGALALQRELGGRSAVLAWVGYRTPS
                     TVSPDVLTPGRAAEAAPGLRAFVGAVAKLRPTARLSVLCHSYGAVVCGRAASGLNVADL
                     VLFGSPGAGVENVSALHTPATVWAGRGDDDWIADVPHGQLQLPFGTLGLGADPVTPEFG
                     ARVFAAGPGGHSDYLKPGSVSLRNLARIVSGQAPSEERSDA"
     gene            3801..4562
                     /locus_tag="TU31_RS25105"
                     /old_locus_tag="TPA0598_07_05210"
     CDS             3801..4562
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS25105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_07_05210"
                     /product="MFS transporter"
                     /protein_id="WP_052719039.1"
                     /transl_table=11
                     /translation="MGGVIHHARRGPAAGTVDAPGRPPAPLLAVCAGYFMVILDVTVIN
                     VAVPVVGRDLSASLTGIQWITDGYTLVFAGLLLTGGALGGRPAQCALIATVALLTTVLN
                     EAGRRGWADPLILTGAGLCLLSAVAFVLRERLARTPVLPLRLLCSRPMSGAAAIGLLFN
                     FAFYGMIFTASLSFQHHRGLSALRTGLALFPAVAMTMFASVLSGRLARRTGHRPLVVTG
                     MLLGGRRPGSGLRPASRPGCGRAWPSAPLRI"
     gene            4770..5399
                     /locus_tag="TU31_RS25110"
                     /old_locus_tag="TPA0598_07_05220"
     CDS             4770..5399
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091443.1"
                     /locus_tag="TU31_RS25110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05220"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_042158434.1"
                     /transl_table=11
                     /translation="MSTLIVTAFITLDGVMQAPGGPDEDVDAGFAHGGWQVPYVDDDFM
                     DLMTGVFERTADHLLLGRKTYDIFATYWPRVTDPDNPIAVKLNSMPKYVASRTLTSLEW
                     NNSQLLAGDAAEAVARLKGQLDGVLMTQGSSDLIRTLQQHDLVDEYRLLINPVILGTGK
                     RLFAEGAAPTAWRLTESRTTGTGVQYCVYQRAGKPEYGTFELDEQD"
     misc_feature    complement(5476..5492)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     gene            5720..6505
                     /locus_tag="TU31_RS25115"
                     /old_locus_tag="TPA0598_07_05230"
     CDS             5720..6505
                     /NRPS_PKS="Domain: Thioesterase (22-246). E-value: 6e-38.
                     Score: 123.5. Matches aSDomain:
                     nrpspksdomains_TU31_RS25115_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091578.1"
                     /locus_tag="TU31_RS25115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05230"
                     /product="thioesterase II family protein"
                     /protein_id="WP_052719061.1"
                     /sec_met_domain="Thioesterase (E-value: 6.4e-38, bitscore:
                     126.8, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.8e-10, bitscore:
                     35.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVAASAVPERVVLAARPQAALRLYCVPPAGAGPDCYLRWAPLLP
                     SWIEPCSVALPGRGTRAAEPSLTDPAYLSARLAAVLDDWTDPRPFAVFGHSAGALLAYE
                     AIRHLRRTHGRLPSLLAVSSLSAPHIDAYSAGLPPRLTAGLEGIRELVGPIPDQLLADA
                     RLMAAACTPLLADCLLLLHYRHRPEPPLDVPLALYGGEHDPVTSVPDLQAWNDLVTTPA
                     PVQLFPGGHTYLQTETKALVDRLTETLDPALYARPVATA"
     aSDomain        5786..6457
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS25115_Thioesterase.1"
                     /evalue="6.00E-38"
                     /label="TU31_RS25115_Thioesterase.1"
                     /locus_tag="TU31_RS25115"
                     /protein_end="246"
                     /protein_start="22"
                     /score="123.5"
                     /tool="antismash"
                     /translation="RLYCVPPAGAGPDCYLRWAPLLPSWIEPCSVALPGRGTRAAEPSL
                     TDPAYLSARLAAVLDDWTDPRPFAVFGHSAGALLAYEAIRHLRRTHGRLPSLLAVSSLS
                     APHIDAYSAGLPPRLTAGLEGIRELVGPIPDQLLADARLMAAACTPLLADCLLLLHYRH
                     RPEPPLDVPLALYGGEHDPVTSVPDLQAWNDLVTTPAPVQLFPGGHTYLQTETKALVDR
                     LT"
     CDS_motif       5984..6043
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TU31_RS25115_0001"
                     /evalue="1.90E-05"
                     /label="NRPS-te1"
                     /locus_tag="TU31_RS25115"
                     /protein_end="108"
                     /protein_start="88"
                     /score="17.2"
                     /tool="antismash"
                     /translation="PFAVFGHSAGALLAYEAIRH"
     gene            6502..8112
                     /locus_tag="TU31_RS25120"
                     /old_locus_tag="TPA0598_07_05240"
     CDS             6502..8112
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091577.1"
                     /locus_tag="TU31_RS25120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05240"
                     /product="MFS transporter"
                     /protein_id="WP_245698694.1"
                     /transl_table=11
                     /translation="MTAAAPARTPAAPVRRAAAAAVVCLGLFMLGLDLTVLNVAVPDLQ
                     GGLDTSTAQVQWIVDGYALVLGGTVLAVGAFTDAWGRRRSFVCGVAVCAGASLGGAVSA
                     QPWQVIAARCIMGAGAALLMPATLAVIHQLFPEARLRSRAIAAWAAVGGMGGLCGPVIG
                     GWLVEHFSWRAAFWINLPLAAVIIVLALLLVPESHARRRAGFDVPGAALSAAGLLVLVW
                     SITESPHRGWTSPAALTGFAAAALLLAAFVRRQLHTPAPMLPLSLLRVPAIGVAAAALA
                     LMSFAMFGALFVLTLYLQGVLGFSPWQAGLRTLPLPAGLALGAVCAVPVRARLGGRVPV
                     VGGLALVTVGFAILATTTPDSDYPHCAAFQLVAGVGAGLVAAAATESVMGSVATERAGL
                     GSAINDATRQVGSALGVAVQGSLLAAVFTSRLTASLTDLHAPAPVAAAARHSMLSVPAQ
                     AMRLPGPLRSSVLSAARRAFTDAMTLTAVVAGAVTLLTAAAAARWLGRPDRPDGTPRAG
                     AARLHGPQPAPREEERPAL"
     gene            8393..8656
                     /locus_tag="TU31_RS25125"
                     /old_locus_tag="TPA0598_07_05260"
     CDS             8393..8656
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (6-69). E-value: 3.1e-13.
                     Score: 41.8. Matches aSDomain:
                     nrpspksdomains_TU31_RS25125_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091576.1"
                     /locus_tag="TU31_RS25125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05260"
                     /product="acyl carrier protein"
                     /protein_id="WP_042158436.1"
                     /sec_met_domain="PP-binding (E-value: 1.8e-11, bitscore:
                     40.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTSAELITSTLTETFDLDPAEVTPERTFEDLGLDSLALVEMGLM
                     LQERTGISLDDVPLRTTLGELAALMDSGTADQALTTAPNSGS"
     aSDomain        8411..8599
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS25125_PP-binding.1"
                     /evalue="3.10E-13"
                     /label="TU31_RS25125_PP-binding.1"
                     /locus_tag="TU31_RS25125"
                     /protein_end="69"
                     /protein_start="6"
                     /score="41.8"
                     /tool="antismash"
                     /translation="LITSTLTETFDLDPAEVTPERTFEDLGLDSLALVEMGLMLQERTG
                     ISLDDVPLRTTLGELAAL"
     gene            8656..9885
                     /locus_tag="TU31_RS25130"
                     /old_locus_tag="TPA0598_07_05270"
     CDS             8656..9885
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (76-408). E-value:
                     3.2e-60. Score: 196.1. Matches aSDomain:
                     nrpspksdomains_TU31_RS25130_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091575.1"
                     /locus_tag="TU31_RS25130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05270"
                     /product="beta-ketoacyl synthase"
                     /protein_id="WP_042158438.1"
                     /sec_met_domain="t2fas (E-value: 1.4e-135, bitscore: 447.8,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.2e-52, bitscore:
                     173.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGQCREAAVTGLGVISPAGIGARATWDSLLTGRSTAARDPGLAG
                     LPVDISCQVPDFDTARLVGRKTSWRLDRFVAMALLAARHAVADAGLDPTEWDASRVGVV
                     IGTGTGSMERYVTEFAKLAAGRPLDISPLAITRSVPNMAAAEIALDLTATGPNFAVSTA
                     CASGSSALGVARDLLRAGTCDLVLAGGAESARHPIPAACFHRMGALSRRTDDPAGACRP
                     FDAARDGFVLSEGAAVLVLERPEHARARGARSRAQLAGYGASCDAYHYAAPDPEGRGAA
                     AALTAALADAGLAPRDIDHVNAHGTGTRLNDLAEARALRAVFPEPPAVTSLKGALGHAI
                     GAAGAIEAAVTVMSLQHDTIPPTANHEDPDLDIDLDIVAKAPRRTPLSAAASTSFGFGG
                     QNAALVFRSA"
     aSDomain        8884..9879
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS25130_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.20E-60"
                     /label="TU31_RS25130_PKS_KS.1"
                     /locus_tag="TU31_RS25130"
                     /protein_end="408"
                     /protein_start="76"
                     /score="196.1"
                     /tool="antismash"
                     /translation="MALLAARHAVADAGLDPTEWDASRVGVVIGTGTGSMERYVTEFAK
                     LAAGRPLDISPLAITRSVPNMAAAEIALDLTATGPNFAVSTACASGSSALGVARDLLRA
                     GTCDLVLAGGAESARHPIPAACFHRMGALSRRTDDPAGACRPFDAARDGFVLSEGAAVL
                     VLERPEHARARGARSRAQLAGYGASCDAYHYAAPDPEGRGAAAALTAALADAGLAPRDI
                     DHVNAHGTGTRLNDLAEARALRAVFPEPPAVTSLKGALGHAIGAAGAIEAAVTVMSLQH
                     DTIPPTANHEDPDLDIDLDIVAKAPRRTPLSAAASTSFGFGGQNAALVFRS"
     CDS_motif       9118..9165
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TU31_RS25130_0001"
                     /evalue="3.40E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="TU31_RS25130"
                     /protein_end="170"
                     /protein_start="154"
                     /score="10.2"
                     /tool="antismash"
                     /translation="GPNFAVSTACASGSSA"
     gene            10001..11293
                     /locus_tag="TU31_RS25135"
                     /old_locus_tag="TPA0598_07_05280"
     CDS             10001..11293
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091574.1"
                     /locus_tag="TU31_RS25135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05280"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_052719040.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.6e-48, bitscore:
                     160.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRRTGATAPRTPRDTGPPPGLRTVTAGPDRADTCSAGPGPETVD
                     ADVPAAVGRTLVGVLGEQVARAAGVERTFARDVAARVARFTLDGGKRTRSQFLWWGLRA
                     CQDRPGAGDVETALRVAAAVELLQTCALIHDDAMDRSPLRRGRPAVHAAFAGQYATPDT
                     AEAAGRFGTAAAVLTGDLALAWADDTVAGIELGAAAGPRVRHLWRAMRMEMVAGQYLDL
                     YGQIAGSRSVALAVRTAYLKSARYSVERPLALGAALAGADEPTTRALGAAGRCAGVAFQ
                     FQDDLLGVFGDQERTGKPSGGDIREGKHTYLLAVGRARAVQRRDRAALALLDRCVGDSG
                     LDAADLERVRAVLVATGAPGLVERRIHRLVARSIRHLDAAAPEPAAAARLRGLFASVAG
                     LRTATGHPRPAARTGSASEPVPARADERGTV"
     gene            11290..12825
                     /gene="crtI"
                     /locus_tag="TU31_RS25140"
                     /old_locus_tag="TPA0598_07_05290"
     CDS             11290..12825
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456520.1"
                     /locus_tag="TU31_RS25140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05290"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_042158441.1"
                     /sec_met_domain="DAO (E-value: 9.4e-18, bitscore: 60.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVKGPTDHVVVVGAGLSGLAAALHLLGAGRQVTVVERAALPGG
                     RAGRIESRGYHLDTGPTVLTMPDLIDEAFAAVGERLTDRMELRALHPAYRARFADGSEL
                     DVHTDAEAMTAEVERFAGPRAADGYRRLRRWLQQLYDVQRHRFIDTNFDSPLQLMHPDL
                     ARLAALGGFGRLDDRIGRFLPDARLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAGV
                     YFPRGGMYALPRAMADAAADAGAAFRYGHPVTRLERTGERITAVVTAQDRIPCDAVVLT
                     PDLPVVHRLLGRRPRRPVRLRHAPSAVILHAGTDRTWPRLAHHTLFFGAAWERTFEELT
                     RTGRLMSDPSLLLTRPTASDPQLAPPGRHLHYILAPCPNTETGPGAGEWRDLAPRYRDS
                     LLAVLERRGLTGIGAAIEEYRMVTPADWTAQGLAAGTPFSAAHTFAQTGPFRPRNLVRG
                     TANAVLAGCGTTPGVGVPTVLISGKLAAARITGLRHPRPAAGSSRPATRGIPA"
     gene            12822..13811
                     /locus_tag="TU31_RS25145"
                     /old_locus_tag="TPA0598_07_05300"
     CDS             12822..13811
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091572.1"
                     /locus_tag="TU31_RS25145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05300"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_042158443.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.6e-122,
                     bitscore: 402.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.4e-64,
                     bitscore: 212.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARELDAAGVTDPGLREAYAHCRRLNARHGKTYFLATRLLPAAR
                     RPAVHALYGFARWADDIVDDPATGHTPADRARALDALHRCLDDGLRGGGSREPVVRAVA
                     HTAAVYGIDHRHFADFMASMRSDLTVTDYPTYADLRRYMHGSAAVMGLQMLPVLGTVVP
                     QEEAVPHAAALGIAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRALLRWSRDTGLP
                     DPRITAALQAAAALTRGVYREAQPGLAMLDPVSRPCIRTAFVLYGAILDAVRDDGYAVL
                     HRRAVVSRRRRAATALGGLARLAATRVTARPPAVRSGRVPHYAQEETP"
     gene            13808..14821
                     /locus_tag="TU31_RS25150"
                     /old_locus_tag="TPA0598_07_05320"
     CDS             13808..14821
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091571.1"
                     /locus_tag="TU31_RS25150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05320"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_042158446.1"
                     /transl_table=11
                     /translation="MTQEVRRAPRLPLRLRRRPELWEQQHPTWRDAKPARIAGAVKAAL
                     ARPSGNWFVLGAARDIGAHRAFGRTVAGVEVVAWRDAGGRLIAGPGACPHLGAPLAQGP
                     VRCGILRCRWHGLALDGAPFAGWEPFPAHDDGLLAWVRLDEAGGERPLPQPVLPDRPRP
                     AGAVAAVYTGTGRCEPEDVVANRLDPWHGAWFHPYSFVDLTVLDTPAEHGAERPDGLTV
                     QVSFKVAGRAVVPVTALFTAPGPRTVVMRILEGEGQGSVVETHATPLGPDDLGRPRTAV
                     VEAIVATSRRPGFALARAAAPALRPLMRAAAGRLWRDDLAYAERRWHLRTSGRHPG"
     gene            complement(14900..16462)
                     /locus_tag="TU31_RS25155"
                     /old_locus_tag="TPA0598_07_05330"
     CDS             complement(14900..16462)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888661.1"
                     /locus_tag="TU31_RS25155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05330"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_042158448.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-07, bitscore:
                     26.1, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 9.4e-12, bitscore: 40.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRHDDGGAARRGRDRRARTVPGPPGRDRAAAGGPEVAVVGGGI
                     AGLSAATALAERGVRVTLYERAGVLGGRLAGWPVRLADGSAATMSRGFHAFFPQYYNLR
                     GLLRRVDPGLGMLRRLPDYPLHHRSGLRDSFARVPRTPPWSALGFVALSPSFTWRDLVR
                     MRPGAALPLLDVRVPQVYQRLDRVSAADFLARIRFPEAARHLAFEVFSRSFFADPRELS
                     AAELVLMFHIYFLGSSEGLLFDVPGEPFPQALWQPLGRYLEGHGVRLCTGTDVTRVAPV
                     AGGGMRVAAGEGADRRFDAVVLALDPGGLRRLVAASPEVADAAWRARIGRLRTAPPFLV
                     SRLWLARRVAADRPGFLGTSGFGSLDNVSVLERWEGEAARWSARTGGSVLELHAYAVAP
                     GADREREQRRLVEQLNAVYPETRGVRIIDRRHEWRADCPLFPVGGFHDRPTVHTPDPRL
                     VVAGDTVRTGFPVALMERAATTGFLAANALLARWGLRGQTLWTVPDRGRSAALRWAAGR
                     AGR"
     gene            complement(16459..17187)
                     /locus_tag="TU31_RS25160"
                     /old_locus_tag="TPA0598_07_05340"
     CDS             complement(16459..17187)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091569.1"
                     /locus_tag="TU31_RS25160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05340"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_042158450.1"
                     /transl_table=11
                     /translation="MALLHDGELTAAFDHASRSYDRLVAVNPGYHGQLRRSARRLGLPR
                     AGRGLRVLDLGCGTGASTAALLAVAPHAEITAVDASAGMLARAAGKPWPPGVSFVHAPV
                     ERLADAGVAGGFDAVFAAYLFRNVTDPDAVLGAVREALVPGGRLAVHEYSLSGGAVPRA
                     VWTAVCTGVLRPAGRLAGDAGLYRHLWRSVLAFDTAAEFTGRLRRAGFRQVRALPLTGW
                     QTGITHTFVAATAGAREEGA"
     gene            complement(17226..18416)
                     /locus_tag="TU31_RS25165"
                     /old_locus_tag="TPA0598_07_05350"
     CDS             complement(17226..18416)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091568.1"
                     /locus_tag="TU31_RS25165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05350"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_042158452.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 7.5e-97, bitscore:
                     320.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQDADAVIVGAGAAGLSLAHRLCAPAAGGRPLRVVLVDAPRGPLT
                     PPERTWCYWEAPGGAFDQALTASWERLRVHGPNGEATAGRPEPFRYKMLRSRDFEALVA
                     ARLAGQDTVVRTEATVESVRDVTGGAEVRGHDAAGRPVALRARWAFDSRPAGRLPPART
                     TLQQHFRGWFVRTRRPAFDPTVADLMDFRTPQPDHGLSFGYVLPLNDCAALVEYTEFSR
                     RTVATAAYERALRHYTGQVLRLGAFRVTAVEQGAIPMTDGRFPRRVGRAVFRIGTAGGA
                     TRPSTGYTFASVQRQTALIAAALLAGRPPVPPPPHNAWHRAMDAVLLRALDSGRVDGAE
                     FFTGLFRTVPMERLLRFLDGRSRLWEDVSIGLRTPVLPMLRTVAELPLLPRRTTVR"
     misc_feature    18600..18616
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.37"
                     /tool="antismash"
     misc_feature    complement(18602..18614)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            18630..19217
                     /gene="sigK"
                     /locus_tag="TU31_RS25170"
                     /old_locus_tag="TPA0598_07_05360"
     CDS             18630..19217
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="sigK"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091567.1"
                     /locus_tag="TU31_RS25170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05360"
                     /product="ECF RNA polymerase sigma factor SigK"
                     /protein_id="WP_042158454.1"
                     /transl_table=11
                     /translation="MPVAARGDRSPAPHTGALETLLTRVSRGDQYAFESLYTAVAGSVL
                     GLVRRVVRDPAQSEEVAQEVLIEVWRSAARFDARQGSAMAWIMTLAHRRAVDRVRSVQA
                     AADRDHRAGMGAYTAPFDEVSEQVERRLEREQVRRCLQQLTDLQRESVTLAYYRGYTYR
                     ETADLLGAALGTVKTRLRDGLIRLRDCLGVSA"
     gene            19214..19966
                     /locus_tag="TU31_RS25175"
                     /old_locus_tag="TPA0598_07_05370"
     CDS             19214..19966
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091566.1"
                     /locus_tag="TU31_RS25175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05370"
                     /product="anti-sigma factor domain-containing protein"
                     /protein_id="WP_042158457.1"
                     /transl_table=11
                     /translation="MSTVDLHTLTGAYALGALSEQESAEFTRHLAQCPACTQEVRELQE
                     TAARLALAVAEVPPAGLRTRVMAALPEVRQLPPRGRHATATVVPLRRGIRFRLPYLAAA
                     ACLVVAALAGGLAVHARNEADQQRDRTVRAEQQAAAVSALMTAPDATFHTTALKGGGSG
                     TVVASKRRGQTAFLYHGLPALSGQRVYELWYSRNGAMEPAGLVRTGSSSGAMLLTGGPQ
                     GADGVGVTAEPPGGSSRPTTTPLAVLRL"
     misc_feature    complement(20067..20082)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    20181..20196
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    20186..20195
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.82"
                     /tool="antismash"
     misc_feature    20296..20310
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.81"
                     /tool="antismash"
     gene            20443..20634
                     /gene="tgmA"
                     /locus_tag="TU31_RS25180"
                     /old_locus_tag="TPA0598_07_05380"
     CDS             20443..20634
                     /codon_start=1
                     /gene="tgmA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979382.1"
                     /locus_tag="TU31_RS25180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05380"
                     /product="putative ATP-grasp-modified RiPP"
                     /protein_id="WP_026169961.1"
                     /transl_table=11
                     /translation="MRPFALSYARPAAKSSTSTPYSYDATRQLNVLPDGRPATCSRAVL
                     LATGTTASTAGSKTHFDD"
     gene            20639..21562
                     /gene="tgmB"
                     /locus_tag="TU31_RS25185"
                     /old_locus_tag="TPA0598_07_05390"
     CDS             20639..21562
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tgmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091558.1"
                     /locus_tag="TU31_RS25185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05390"
                     /product="ATP-grasp ribosomal peptide maturase"
                     /protein_id="WP_042158461.1"
                     /transl_table=11
                     /translation="MTVLVLTCEEDLTADIVVSTLQDLGVPLVRLDPADLPGRVALSAE
                     YADNDFHGYLKSGERMVSLGSLRSVWVRRPGTPGARAAEQSAWITAEAEQALYGMLTST
                     QARWMNHPVAAAQARYKPWQLRLAHRSGFLVPATLVTTFPAMARQFAATHQDLVVKSVS
                     GKHPGDPPMVLPTTRISPDTDFSGVAAGPTLLQQHIPKEADIRLTCVGDHLFAARKKAD
                     PEEVDSRFAHQGTWEPVEVPDAVHRSVNSYMSAAQLAYGAFDFAEDPDGAWWFLECNQG
                     GQFGFIQLETDQPIAQAIATWLAVEP"
     gene            complement(21598..22095)
                     /locus_tag="TU31_RS25190"
                     /old_locus_tag="TPA0598_07_05400"
     CDS             complement(21598..22095)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827748.1"
                     /locus_tag="TU31_RS25190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05400"
                     /product="hypothetical protein"
                     /protein_id="WP_078885939.1"
                     /transl_table=11
                     /translation="MQPPPRRAEPLQRLLFGGVYGSVLASALVAALGHEGRPPDPGYDA
                     LWVALTAAASAAAHGYAHSIAHRTSDDKHVTPSAVRSVLMEWPLVAAMVPTMFALFGAY
                     AEWWGEDGAVDVALTINMVALFGWGVWAARVAGRRWAASFRVGGVDVLIGLLIVIANML
                     IH"
     gene            complement(22252..23517)
                     /locus_tag="TU31_RS25195"
                     /old_locus_tag="TPA0598_07_05410"
     CDS             complement(22252..23517)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607866.1"
                     /locus_tag="TU31_RS25195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05410"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_042158925.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.5e-07, bitscore:
                     26.5, seeds: 790, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEKSPARPASPPVKSCTDDEIWRRVTREVADDLAVDALVRDRAG
                     KPPFDELARLREAGLPALLAPPGPAGRGTDWRTACAVIREIAAADGSIGELLGRHWALS
                     WSARFFGTPERADELELRASAGQWLWGGGIDFPDPEPATGPELTLTPAAEGYLLHGCRS
                     FAAGVAVADRLVLGAVHTDTGESLVVCVDPAHPGVAAAPEHDRLGQRLTAAGRISFDGV
                     PVPADQVLGAVPRDEHALAPFATLAPLALRLALVHVGLGIAEGALAEARDITRAGSHGR
                     AAEGPDEDGYAERPGADPYLLLAYGELVTETRTAAAVVESASEALARGLRAGPGLGVDQ
                     RADIAVLVAAAEAVTSRCAMRLTTRVLELTQGADSAADPLGFDRFWRNARVLTARVSPT
                     TRLRDIGDHYLNGTHPPLTLHS"
     gene            complement(23775..24233)
                     /locus_tag="TU31_RS25200"
                     /old_locus_tag="TPA0598_07_05420"
     CDS             complement(23775..24233)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058273.1"
                     /locus_tag="TU31_RS25200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05420"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_042158464.1"
                     /transl_table=11
                     /translation="MRISARADYAVRAALQLADARDAGPLKAEAIAQAQDIPHKFLEGI
                     LNDMRRGGLVQSRRGGSGGYRLARPAEAISIADVIRVVDGPLVSVRGVRPPELSYTGPA
                     RSLLPLWIALRANVREILDGVTLADVASAELPPQVAELTEHPESWTNP"
     misc_feature    24231..24246
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.63"
                     /tool="antismash"
     gene            24410..24946
                     /locus_tag="TU31_RS25205"
                     /old_locus_tag="TPA0598_07_05430"
     CDS             24410..24946
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091554.1"
                     /locus_tag="TU31_RS25205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05430"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_042158466.1"
                     /transl_table=11
                     /translation="MADKGAPIPVTQPAVLETRGPGSVKVALDVNGVSRVVHLEPRVSL
                     LDALREQMALTGSKKGCDQGTCGACTVWVDGRRVLSCLTLAISCEGREVTTIEGLAEGD
                     ELHPMQRAFLEHDAFQCGYCTPGQIMSAVALLNEGHAGTDAEIAEWMSGNICRCAAYPP
                     IRSAIREVRDRKTGQ"
     gene            24948..25946
                     /locus_tag="TU31_RS25210"
                     /old_locus_tag="TPA0598_07_05440"
     CDS             24948..25946
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091553.1"
                     /locus_tag="TU31_RS25210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05440"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_042158468.1"
                     /transl_table=11
                     /translation="MRAISYTRATDVHSAVEAVTSDPGSSFLAGGTTEIDLLRLDVLRP
                     HRLVDINRLPLTGVEERADGGLLIGALARMSEVAEDRAVVERFPMLSQALLLGASAQLR
                     HMASMGGNLMQRVRCAYYRDPESACNKRVPGSGCSALEGVHRGHAVLGTSEHCIATHPS
                     DLAVALVALDAVVHVEGMDGARTIPVDDFFLLPGDTPEREHPLTPGELITAIEVPALPM
                     ARRSLYLKVRDRESYEFALASAAVALALEDGVVREVRLALGGVATKPWRARRAEDVLVG
                     ERADDAAFTRAATAELAPADTRPMNAFKAELARRTLVRALRTVATTGGGTA"
     gene            25943..28192
                     /locus_tag="TU31_RS25215"
                     /old_locus_tag="TPA0598_07_05450"
     CDS             25943..28192
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607862.1"
                     /locus_tag="TU31_RS25215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_05450"
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_042158471.1"
                     /transl_table=11
                     /translation="MTTGATLEAIGRPVDRVDGPAKVTGHGRYSAEITLPNTAYAALVG
                     ARTASGRITGIRTEAAERADGVLAVLTHQNLPKIAGRPALLPSLAGHAAPGESFFPLQD
                     DVVHYFGQPVAVVIADSLERAHFAARQLHVDYDRRPSVTTLDEGRDQAYEPEAIFAGFL
                     PARSVRGDVEAGFQAATQRLDATFHFAANHHNPIEPSATTAVWDGDRLTLYDATQGIVA
                     TQSTVAALLGIPPSKVRVRASFVGGGFGCKAMIWPHVTLAALAAREVGRPVKLALTREQ
                     MFTSCGHREEQEQRIELGATDDGRLTALRHHKLSLTSPFDEWAEPSLGMAGQVYACPHY
                     EGVYRLIRSNTMTPTFTRGPGETTGMYAMECVMDELAHRIGVDPVQLRLRNHAEADPHT
                     GHPWSSDGAEECYRRGAARFDWQSRNPEPRSERDGNRLIGKGMATAGYPVLFPMQPQRA
                     RARLYADGTAVVQAGTQEFGTGAGTAMTQVAADGLGVALRNVRFEYGDTDLPNVAAAVG
                     SAGAGMISAAVYTAATTLRDQMIEQAIADPGSPLHQADPATVVVREGRMQLRDRPDTGE
                     SYRSLMARHFMTDLEALGSWSPPPQDLPYGLATFGAQFAEVAVDPDLGTVRVRRMVGAF
                     APGRVLNAKTARSQVVGGMLWGLGQALLEGSSTDPRDGRWANASLGEYLVPVNADAPDV
                     AVEFVEVPDTVVNPLGVKGLGEVGMVGAAAAIANAVFHATGYRARELPIRIEHLL"
ORIGIN
        1 tccggacgtc catcaggacg acgtccgggg cgagccggtc gacctgggcg agggcgtcga
       61 ggccgtcgac ggcctggccg atgacctcga tatcgggttc ggcgttgagc agcaccgtga
      121 agccctgacg gaccatcatc tggtcgtcgg cgatcagcac gcggatggtc gtcatggggc
      181 gggctcacgg gggtcggcag gctgcgcggc ctgggtgggc agaatcgcgg tcacttcgta
      241 accgccgtcg ggggtggggc cggtggcgag ttcgccgccg agcatggcgg tgcgctcatg
      301 catccccagc aggccgtggc cggcgcccgg cgagggcggg gcgggccggt ccggcgcggt
      361 gttggcgacc cggatggtga gaccgccgga ccggtacccg agggccaccc gcaccttcgc
      421 gccgggcgca tgccggagcg cgttgctgag cgcctcctgg acgatacgga acgccgacag
      481 ctcgactccc ggggacagcg ggcgcacctc accggtgatc tcggtggtga ccctgagccc
      541 ggctccccgc accgtgccga ccagttcgtc cagccggccg agagtgggct gcggggtgtg
      601 ccgcacgccg tccgccaggg cttcctccga gcgcagcacg cccagcaccc gccggagttc
      661 ggtcagcgcc tcgacggcgc tcccgcggat gcccgcgagg ttctccttga gctcgtcggt
      721 ggggtccttg accaggtgcg gggcgacctg ggcctggatg gatatcaccg acatgtggtg
      781 ggcgaccacg tcgtgcagtt cgcgggcgat ccggttgcgc tcctccagca gggtgcgccg
      841 ggcccgctcc ccggcggtga gcacctcctg ctcgacgagc tgggtacggg ccacccggcg
      901 gccgcgcagc gaagtgccca ccaccaccgc gagcgtgaag gtcacgacgt cctggacgac
      961 cgtcacgtcc tgggcggagg tctggaggac cggagcggcc gcacccggca gggtcggctc
     1021 cggtgccggc gtcacgaaga ccagggcggc caccgccgcc aggagcgaga accccagcgc
     1081 ctcggccgcg atgcgggggc ggacccgcag cgcgagaagg aacagcacca gggcgtgcag
     1141 cgagatgccc gggatgctcc aggaccacag cggggcgtgg ctgaccttga gcgaaccgac
     1201 gttcctggcc aggaagagcg cgatcgtcga cagccaccag gcgggcaccg gacgggacag
     1261 cgcgaggacc acggcacctg attggagcgc cgcgagcacc aggacggacg tcatcacggc
     1321 cggcccgaaa tccccttcac cctgcaccgc gttgagccag cccatgagca ccgcggccag
     1381 caccacatgg gcgtgcggca gccggcccag ccagcgcaac cggggcagtg gatcgcgagc
     1441 caccgtccac agatccgcgc gcagggtatg cggaatcccc cgcacggccg cccacagccg
     1501 cggccccctg ctcttccaac ccccctggct cacacggtgc atcctaagca cgccgcaccg
     1561 ccctggcctc agcgggacgc cccgcccgga ccaccgtggc gccgcgccgc cgcccctgtt
     1621 cgtacgtgcg gaacgcggcc cagcacacca tcagcgcgag cgcgaacacc ggcagccaga
     1681 ccagccgggc gaggacccag ccggcgccgt cgggcagggt gtgcagaccg ggcaggaacc
     1741 caccggtgag cagaccgacc gcggtgaccg ccatcatcgc ggtctgatgc cacaggaaga
     1801 gcgtcatcgc cgagaggttc agcagcgcca ccgccgcccg gacggcgggg cgttggagca
     1861 gccgccgcag cgggccgagc agcagcaggg ccgccccgca ctgggcgaga ccgaaggtga
     1921 ccgccgcgag agtgggcggg ttgaggttgg agatgccggc gccgggcacc ccgaccatgg
     1981 cggccgggta accggcccac aggacgagtc ctgcggtggt cgcggcgccg ccgagcagca
     2041 gcacccaagc cgtcgcccgg ccccgcagcc cgccccgggc ccaggccgcg cccaggcagt
     2101 acggcaccag ccagccggcc gccacattgg tccagccgag ccaggccggg ccgccgagcc
     2161 cgaaccggat cagatcgatg tgcaggacga cggcgagtgg ccacagcgga tgcagccggg
     2221 cgaccagcgg agtcgccgcc gtcagcgcgg cgaacaccag caggaaccag agcggggaca
     2281 gcgccagttt gccgagtgtc cagacggtgt ccagaccggc cccggcgacg agcagcgcgc
     2341 ccgccaccac gctccagacg gccagcatgg ccaccacggg ccggaacagc cgagccgtcc
     2401 gggcgccgag ccaccggcgg taggttccgc cccgggcacg ggtggcggca tggctcgtcg
     2461 ccgccatctg accgcccacc agaaagaaga ccgccagggt ctggagaagc caggagaccg
     2521 gggtgaggta gggcagctga tggagggggc tgacgacccg cacggtgccg ctgtcggcga
     2581 ccagggcggt caccagccag tggccgagca tcaccccgag aatggcgagc gcacgcagcg
     2641 cgtcgacgcc gcggtcacgg tcggccggtg tcgcggcggc gatccgccgg atgagctcac
     2701 gcatcgcttc tctcctcgga aggggcctgg ccggacacga tccgggcgag gttccgcagg
     2761 gacacggagc cgggcttgag gtagtcgctg tggcctcccg ggcctgccgc gaagacccgg
     2821 gcaccgaact cgggcgtgac cgggtcggcg cccaacccga gcgtgccgaa gggaagttgc
     2881 agctgcccgt gcggcacatc ggcgatccag tcgtcgtcgc cccggccggc ccacacggtc
     2941 gccggggtgt gcagcgcgga gacgttttcg acgcccgcgc cggggctgcc gaacagcacc
     3001 aggtccgcga cgttcagccc tgacgcggcc cggccgcaga ccacggctcc gtacgaatgg
     3061 cagagcaccg agagccgggc cgtgggacgc agcttcgcca cggcgccgac gaaggcgcgg
     3121 agtccgggag cggcctccgc cgcgcggccg ggggtgagca catcgggact caccgtgctc
     3181 ggcgtccggt accccaccca ggcgagcacg gcggatcggc cgcccaactc ccgctggagc
     3241 gccagcgcac cggaccgcag acgtgcgtac ctgtcgaggt gggtgtccga ccccggcacc
     3301 agtacggcga tccgctcggc ccgtgccagg tcgccgaaga cctcggtggt gcggcctccg
     3361 ttgcggccgt cgaagaacag gaactgccga gcagggccgg ccatcccgcg cagcgcctcg
     3421 gcccgcgccc ggtcgccgtg gccctcggcc atccgctccg ccgcacggat gcccgcacgg
     3481 ttgacggcgt agcgctcggc gagcgcgccg ggtgtggcgg accgcagcgg agcgagggcc
     3541 ttgggggcgg gtgccgggac ggccgcgggg cgggccgcac ccgacacggg caccaccacc
     3601 gaggtgacga cgaaagcggc gagcagagtg cgcagcggac ggctgccgcg cgggcgggac
     3661 gccatgatga ctggtccttc cgtaccggaa gccggtcgtg gcttccggta ccgaagctat
     3721 ggagcagggc acttggtcga cgtcccgccg gggagcgtac ttccgtcgta gctctcaggt
     3781 atcaggggta gggggcatcg gtgggcggcg tgatccacca cgcccggcgc ggaccggccg
     3841 ccggcacggt cgacgcgccg ggccggccgc cggctccgct tctcgcggtc tgtgcgggct
     3901 acttcatggt catcctggac gtgaccgtca tcaacgtcgc ggttccggtg gtgggacggg
     3961 acctgtccgc ctcgctcacc gggatccagt ggatcaccga cggctacacc ctggtcttcg
     4021 ccggtctgct gctcaccggt ggcgcgctgg ggggccggcc ggcccagtgc gcgctgatcg
     4081 ccacggtcgc cctgctcacc accgtcctca acgaggccgg acgacggggc tgggccgacc
     4141 cgctgatcct caccggagcc ggtctgtgtc tgctgtcggc cgtcgcgttc gtcctgcgcg
     4201 agcgcctggc ccggaccccc gtgctgcccc tgcggctgct gtgctcccgt ccgatgagcg
     4261 gggccgcggc catcgggctc ctcttcaact tcgccttcta cggcatgatc ttcaccgcca
     4321 gcctctcctt ccagcaccac cgcggcctga gcgcgctgcg caccgggctc gccctcttcc
     4381 cggcggtggc catgaccatg ttcgcctccg tcctgtccgg gcggctggcc cgccgtaccg
     4441 gccaccgacc gctcgtggtc accggcatgc tcctgggcgg ccgccggccc ggatccggac
     4501 tacggccggc ttcccggccg ggctgcggac gagcatggcc atcggcgccg ctgcgtatct
     4561 gatggctgcc gcgctcgcgt tcttctgcgt cccgccgaag gggcaccgcc aggccgccgg
     4621 ctgacgggcg gcgcgccgcg acgtacggac tgcggcgata tgtcgtggta tgtagccagg
     4681 gccggccggt cgcgcggcga gcgatgagtt ctcgccggcc cgggagtcca cccctgtacc
     4741 ggcagattcc gcacccgaag ggcagcacca tgagcacact gatcgtcacc gcgttcatca
     4801 ccctggacgg cgtcatgcag gcccccggcg gcccggacga ggacgtcgac gcgggcttcg
     4861 cgcacggcgg ctggcaggtc ccgtatgtcg acgacgactt catggatctc atgaccgggg
     4921 tcttcgagcg caccgccgac catctcctgc tcggccggaa gacctacgac atcttcgcca
     4981 cctactggcc ccgcgtcacc gacccggaca acccgatcgc cgtgaagctc aacagcatgc
     5041 ccaagtacgt cgcctcgcgc accctgacca gcctggagtg gaacaactcc cagctgctcg
     5101 cgggcgacgc cgcggaggcg gtcgcacggc tcaaggggca gctcgacggg gtgctcatga
     5161 cgcagggcag cagcgacctc atccgcaccc tccagcagca cgacctcgtc gacgagtacc
     5221 ggctgctgat caacccggtg atcctcggca ccggcaagcg gctgttcgcc gagggcgccg
     5281 cccccaccgc ctggcggctc acggaatccc gcaccaccgg cacgggcgtc cagtactgcg
     5341 tctaccaacg ggccgggaag cccgagtacg gcaccttcga gctcgacgag caggactgag
     5401 gacacggccg ggctcccggc tcccgcgcgc cggccggccc ggctgccgcc gttggtgtca
     5461 gaggggggcg gcgccttgcg tggtgtgtgg agtgcggggg cgggggaggg cagggtcggc
     5521 gtgggcaccg gtccggtgtc cggccggagg tctccggacc ccgccggccg gcgggccgcg
     5581 cggccggaac gccccgggcc gacggccgca cccggccggt ccggggcggc cggcggtgca
     5641 cgggcggagc ccggaccagt ggagcgcgag gcgaagggcg tgtgtcgtgg gtgtcggttt
     5701 cgcagaagag tcgacgtcgg tgacggtagc ggcgtcggcg gtgccggagc gtgtcgtgct
     5761 ggccgcccgt ccgcaggcgg cgctgcgctt gtattgcgtg ccgcccgccg gggccgggcc
     5821 ggactgctat ctgcgctggg cgccgttgct gccgtcctgg atcgagccct gctccgtggc
     5881 actgcccggc cgtggcaccc gcgccgcgga accctcgctg accgaccccg cgtatctgag
     5941 cgcccggctc gccgcggtgc tggacgactg gaccgacccc cggccgttcg cggtcttcgg
     6001 acacagcgcg ggcgccctgt tggcctacga ggcgatccgc catctgcggc gcacccacgg
     6061 ccggctgccg tcgctgctgg cggtgtcctc actgtccgcg ccgcatatcg acgcctacag
     6121 cgccggcctg ccgccccggc tgaccgccgg gctggaaggc atccgcgaac tcgtcggccc
     6181 gatccccgac caactcctcg ccgacgcccg tttgatggcc gcggcctgca cccccctgct
     6241 ggccgactgt ctgctgctcc tgcactaccg gcaccgcccc gagccaccgc tcgacgtgcc
     6301 gctggccctc tacgggggtg aacacgaccc cgtcaccagc gtgccggacc tccaggcctg
     6361 gaacgacctg gtcaccacac cggccccggt ccagctcttc cccggcgggc acacctacct
     6421 ccagacggag acgaaagccc tggtggaccg gctcacggag accctggacc cggccctgta
     6481 cgcccgcccc gtggcgacgg catgacggcc gccgcgccgg cccgcacacc ggccgcaccc
     6541 gtacgccggg cggcagcggc cgccgtggtg tgcctcggac tcttcatgct gggcctggat
     6601 ctgacggtcc tcaatgtcgc ggtgcccgac cttcagggcg gcctcgacac ctccaccgcg
     6661 caggtccagt ggatcgtcga cggctacgcc ctggtcctgg gcggcacggt gctggccgtg
     6721 ggcgccttca ccgacgcctg gggccggcgg cgttccttcg tctgcggggt ggcggtctgc
     6781 gcgggcgcct cgctgggcgg cgcggtctcc gcgcagccgt ggcaggtgat cgccgcacgc
     6841 tgcatcatgg gggccggggc cgcgctgctg atgccggcga cgctggcggt catccaccag
     6901 ctgttccccg aggcccggtt gcgcagccgg gcgatcgccg cctgggccgc ggtcggcggc
     6961 atgggcggcc tgtgcggtcc ggtcatcggc ggctggctgg tggagcactt ctcctggcgc
     7021 gccgccttct ggatcaatct gccgctcgcc gccgtcatca tcgtcctggc cctgctcctg
     7081 gtacccgagt cccatgcccg gcggcgcgcc ggcttcgatg tgcccggcgc cgcgctgtcc
     7141 gccgcgggcc tgctggtcct ggtgtggtcc atcaccgaga gcccgcaccg cggctggacc
     7201 agcccggccg cgctgaccgg attcgccgcc gccgcgctgc tgctggccgc gttcgtccgc
     7261 cgccagctgc acacccccgc accgatgctc ccgttgtccc tgctgcgggt accggccatc
     7321 ggggtggccg cggcggctct ggcgctgatg tccttcgcca tgttcggcgc gctgttcgtg
     7381 ctgacccttt acctccaggg ggtgctgggc ttcagcccct ggcaggccgg gttgcggacg
     7441 ctgcccctgc cggccgggct ggcgctcggc gcggtgtgcg cggtgccggt acgggcacgg
     7501 ctgggcggcc gggtccccgt cgtgggcgga ctggccctgg tgacggtcgg tttcgcgatc
     7561 ctggcgacca ccaccccgga ctccgactac ccgcactgcg cggccttcca gctggtggcg
     7621 ggggtcgggg ccgggctggt ggcggccgcg gccaccgaat cggtgatggg ctcggtcgcc
     7681 accgaaagag ccggactcgg ctcggccatc aacgacgcca cccgccaggt cggttccgcc
     7741 ctcggggtgg ccgtgcaggg ctccctgctc gcggccgtct tcacctcccg gctcaccgcc
     7801 tccctcaccg atctgcacgc ccccgcgccg gtggccgccg cggcccggca cagcatgctg
     7861 tcggtccccg cacaggcgat gcggctgccc ggcccgctgc gcagcagtgt gctgtccgcc
     7921 gcgcgacgcg ccttcacgga cgccatgacg ctcaccgccg tcgtcgccgg agccgtcacc
     7981 ctgctcaccg ccgcggccgc cgcacgctgg ctgggccggc cggaccgccc ggacggcacg
     8041 ccccgggccg gcgctgcccg gctccacgga ccgcagccgg cgcccaggga agaagagcgt
     8101 ccggcgctat agagcgataa gtcactcgtt cagaggtgcc ttcatgaccc tggccggagg
     8161 agacggtcgg cgacagtaga gcgcgagccc gaccctgcgc accggccccc ggtgccggcc
     8221 gcccccgccc gcctggagcc acgatgcaca ccccgtccgc accagcacct cccacggtgc
     8281 cccgggctcc tgccgcgcgg cctcgcggcg cccgtccgca gcgactcctc gcgcccggac
     8341 ggcgccccgc ccgcggcggc cggcaccccc accccaaccg aaggagccac ccgtgcccac
     8401 cagtgcagag ctgatcacca gcaccctcac cgagaccttc gacctcgacc cggccgaggt
     8461 cacccccgag cgcaccttcg aggacctcgg cctggactcc ctcgcgctgg tcgagatggg
     8521 cctgatgctc caggagcgca ccgggatctc gctggacgac gttccgctgc ggacgaccct
     8581 cggcgaactc gccgcgctga tggacagcgg tacggccgac caggccctga ccaccgcgcc
     8641 gaacagcggc agctgatgtc cggtcagtgc cgtgaggccg ccgtcaccgg cctgggcgtc
     8701 atcagcccgg ccgggatcgg tgcacgggcc acctgggact ccctgctcac cggccggtcc
     8761 accgccgccc gggacccggg gctggcgggg ctgccggtgg acatctcctg ccaggtgccc
     8821 gacttcgaca ccgcgcgcct ggtcggcagg aaaacctcct ggcggctgga ccgtttcgtc
     8881 gccatggcgc tgctcgccgc ccggcacgcc gtcgccgacg ccggtctcga ccccaccgag
     8941 tgggacgcct cgcgggtcgg cgtggtcatc ggcaccggca ccggcagcat ggagcgctac
     9001 gtcaccgagt tcgccaagct cgcggcgggc cgcccgctgg acatctcgcc cctcgccatc
     9061 acccgcagcg tgcccaacat ggcagccgcc gagatcgccc tcgacctgac ggccaccggg
     9121 cccaacttcg ccgtctccac cgcctgcgcc tccggcagca gcgccctcgg cgtggcccgt
     9181 gacctcctgc gcgccgggac ctgcgacctc gtgctggccg gcggcgcgga atccgcccgc
     9241 caccccatcc ctgcggcctg cttccaccgc atgggcgccc tgtcccggcg tacggacgac
     9301 cccgcgggcg cctgccgccc cttcgacgcc gcacgcgacg gcttcgtcct ctccgaaggc
     9361 gccgccgtcc tggtgctgga acgcccggag cacgcccgcg cccgcggtgc gcgatcgcgc
     9421 gcacaactgg ccggctacgg ggcgagctgc gacgcctacc actacgcggc tcccgacccc
     9481 gagggccggg gagcagcggc cgccctcacc gcggccctgg ccgacgccgg actggcgccc
     9541 cgggacatcg atcacgtcaa tgcgcacggc accggcaccc gcctgaacga ccttgccgaa
     9601 gccagggccc tgcgcgccgt cttccccgag ccgcccgccg tcacctccct caagggcgcg
     9661 ctcggccacg ccatcggagc ggcgggcgcc atcgaggcgg ccgtcacggt catgagcctc
     9721 caacacgaca ccatcccgcc caccgccaac cacgaggacc ccgacctcga tatcgacctg
     9781 gacatcgtgg ccaaggcacc tcgccgcacg cccctgtccg ccgccgccag cacctccttc
     9841 ggcttcggcg gccagaacgc cgccctcgtc ttccggtccg cctgaccacg gaccggaccg
     9901 cgcacggccg ccgtgccgca ccccgtcgca cccggcggcg ggctcccggt acgcggcccg
     9961 ccgccgacct ccgccgaccg acgcgacgag aggaaccacg atgcgccgtc gtaccggggc
    10021 caccgcgccc cgcacgccgc gcgataccgg cccgccgccc ggtctccgta ccgtgacggc
    10081 cggaccggac cgtgctgaca cctgctcagc cggtcccgga ccggagaccg tcgacgcgga
    10141 tgtaccggcc gccgtgggac ggacgctcgt cggcgttctc ggcgagcagg tcgcgcgggc
    10201 ggccggggtc gagcgcacct tcgcacggga cgtcgccgcc cgggtcgcgc gcttcaccct
    10261 ggacggcggc aagcgcaccc gctcccagtt tctgtggtgg gggctgcggg cctgtcagga
    10321 ccgcccgggc gccggtgacg tggaaacggc gctccgggtg gccgccgccg tcgaactcct
    10381 ccagacgtgt gcgctcatcc acgacgacgc catggaccgg tcaccgctgc gccgcggccg
    10441 gcccgcggtg catgccgcgt tcgccggtca gtacgcgaca ccggacaccg cggaagcggc
    10501 cgggcggttc ggcaccgccg ccgccgtact caccggcgat ctcgccctcg cctgggcgga
    10561 cgacacggtc gccggtatcg aactcggcgc ggcggccggc ccgcgggtgc ggcacctctg
    10621 gcgggcgatg cggatggaga tggtggccgg tcagtacctc gacctctacg gccagatcgc
    10681 cggctcccgc tccgtggcgc tggccgtccg caccgcgtac ctcaagagcg cgcggtattc
    10741 ggtggagcgg ccgctggccc tcggcgcggc gctggccggg gccgatgagc ccaccacccg
    10801 cgccctcggt gccgccggcc gctgtgccgg ggtggccttc cagttccagg acgatctgct
    10861 gggggtgttc ggggaccagg agcggaccgg caaaccgtcc ggcggcgaca tccgggaggg
    10921 caagcacacc tatctgctcg cggtcggccg ggcccgcgcc gtgcagcgcc gcgaccgggc
    10981 ggctctcgcg ctcctcgacc gctgtgtcgg tgacagcggg ctggacgccg ctgacctgga
    11041 gcgggtgcgc gccgtcctcg tcgccaccgg cgcccccggc ctcgtcgagc ggcgcatcca
    11101 ccggctggtc gcccgcagca tccgccatct ggacgccgcc gccccggaac ccgccgcggc
    11161 cgcccggctg cgcggcctct tcgcttccgt cgccggcctc cgcaccgcca ccggccaccc
    11221 gcgcccggca gcacgaaccg gcagcgcatc cgagcccgtt cccgcccggg cggacgaaag
    11281 gggcaccgta tgagaaccgt caagggcccc accgaccatg tggtggtggt cggcgccggt
    11341 ctctccggac tggccgccgc gctgcatctg ctcggcgccg gacggcaggt gacggtcgtc
    11401 gagcgggcgg cgctgcccgg cggccgggcc ggccgtatcg aaagccgcgg ctaccacctc
    11461 gacaccggac cgaccgtgct gaccatgccg gacctcatcg acgaggcgtt cgccgcggtc
    11521 ggcgagcgcc tcaccgaccg gatggagctg cgggccctgc accccgccta ccgcgcccgg
    11581 ttcgccgacg gcagcgaact ggacgtccac acggacgcgg aagccatgac ggccgaggtc
    11641 gaacggttcg ccggcccccg ggccgccgac ggctaccgcc ggctgcgccg ctggctccag
    11701 cagctgtacg acgtccagcg ccaccgcttc atcgacacca acttcgactc accgctccag
    11761 ctgatgcacc cggacctggc ccgcctcgcc gcactcggcg gcttcggccg gctcgacgac
    11821 cggatcggcc gcttcctgcc cgacgcccgg ctgcgcaggg tcttctcctt ccaggcgctg
    11881 tacgccgggg tcccgcccgc gcgcgccctg gccgcctacg ccgtgatcgc ctacatggac
    11941 accgtcgccg gggtgtactt cccccgcggc gggatgtacg ccctgccccg ggccatggcg
    12001 gacgcggccg ccgacgccgg tgccgccttc cgctacggac accccgtcac ccggctggaa
    12061 cgcaccggcg aacggatcac ggcggtggtc accgcgcagg accgcatccc ctgcgacgcg
    12121 gtggtcctca cccccgatct gccggtcgtg caccggctgc tcggccggcg cccccgccgc
    12181 ccggtccggc tccgccacgc accgtccgcg gtgatcctgc acgccggcac cgaccggacc
    12241 tggccgcggc tggcgcacca cacgctcttc ttcggcgccg cctgggagcg gaccttcgag
    12301 gaactcaccc gcaccggccg gctgatgagc gacccctcgc tgctgctcac ccgccccacc
    12361 gcctccgacc cgcaactcgc cccgccgggg cggcacttgc actacatcct ggcgccctgc
    12421 cccaacaccg agaccggccc gggagccggg gagtggcgcg acctcgcccc ccggtaccgc
    12481 gacagcctgc tcgccgtcct cgaacgccgg ggactcaccg gcatcggcgc cgccatcgag
    12541 gagtaccgca tggtcacccc ggccgactgg acggcacagg ggctcgccgc cggaacgccg
    12601 ttctccgccg cccacacctt cgcgcaaacc ggtcccttcc gcccccgcaa cctcgtacgc
    12661 ggcacggcca acgccgtact ggcgggctgc ggcaccaccc caggggtcgg cgtccccacc
    12721 gtcctgatct ccggcaagct cgccgcggcc cggatcaccg gcctgcggca cccacgtccc
    12781 gccgccggtt cgtcccgccc cgccacgaga ggcatcccgg catgaccgca cgcgaactcg
    12841 acgccgcagg cgtcaccgac cccggcctcc gtgaggccta cgcccactgc cgccggctca
    12901 acgcccggca cggcaagacc tacttcctcg ccacccggct gctgcccgcg gcccgccgcc
    12961 cggccgtaca cgccctgtac ggcttcgccc gctgggccga cgacatcgtc gacgaccccg
    13021 ccaccggcca cacccccgcg gaccgcgccc gggcgctcga cgccctccac cgctgcctcg
    13081 acgacggact gcggggcggc gggagcaggg aaccggtggt gcgcgcggtg gcgcacaccg
    13141 cggcggtgta cggcatcgac caccgccatt tcgccgactt catggcctcg atgcgcagcg
    13201 atctgacggt gacggactat ccgacctacg ccgacctgcg gcgctatatg cacggctccg
    13261 ccgcggtgat ggggctccag atgctgccgg tgctcggcac cgtcgtaccg caggaggaag
    13321 ccgtgccgca cgccgcggcc ctcggcatcg ccttccagct caccaacttc ctgcgcgatg
    13381 tcggcgagga cctcgaccgg ggccgcgtct acctccccgc cgacctgctc gcggcgcacg
    13441 gcgtcgaccg cgcactgctc cggtggagcc gggacaccgg cctcccggac ccgcggatca
    13501 ccgcggccct tcaggcggcc gccgcactca cccgaggcgt ctaccgcgag gcgcaacccg
    13561 gcctcgccat gctcgacccg gtctcccgcc cctgtatccg caccgcgttc gtcctctacg
    13621 gcgccatcct cgatgccgtg cgcgacgacg gatacgccgt gctgcaccgc cgcgccgtgg
    13681 tctcccgccg acgccgcgcg gccaccgccc tcggcggtct ggcccgtctc gccgccaccc
    13741 gtgtcaccgc ccggccgccc gcggtgcggt ccggccgggt gccgcactac gcgcaggagg
    13801 aaaccccatg acccaggagg tccgccgggc cccgcgcctc ccactccggc tgcgccgccg
    13861 gcccgagctg tgggaacagc agcaccccac ctggcgcgac gcgaaacccg cgcgcatcgc
    13921 cggcgccgtc aaggccgccc tcgcccgccc gtccggcaac tggttcgtcc tcggcgcggc
    13981 ccgcgacatc ggagcgcacc gtgccttcgg ccgcaccgtc gccggggtcg aggtggtcgc
    14041 ctggcgggac gccggcggcc gcctgatcgc cggccccggg gcctgcccgc acctcggcgc
    14101 gcccctcgcc cagggacccg tacgctgcgg catcctgcgc tgccggtggc acggactcgc
    14161 cctggacggc gccccgttcg ccggctggga acccttcccc gcccatgacg acggactgct
    14221 ggcctgggta cggctcgacg aggcgggcgg cgaacggccg ctgccgcagc ccgtgctgcc
    14281 cgaccggccg cgcccggcgg gcgccgtcgc cgccgtctac accggcaccg gccggtgcga
    14341 acccgaggac gtggtcgcca accgcctcga cccttggcac ggcgcctggt tccaccccta
    14401 ctccttcgtc gacctcaccg tgctcgacac ccccgcggag cacggtgcgg aacggcccga
    14461 cggcctcacc gtccaggtgt ccttcaaggt cgccggacgc gcggtggtgc cggtcaccgc
    14521 gctgttcacc gccccggggc cccgtacggt ggtgatgcgc atcctggagg gcgaagggca
    14581 gggatccgtg gtggagaccc atgccacgcc cctgggcccg gacgacctgg gacgcccgcg
    14641 caccgcggtc gtcgaagcga tcgtcgccac ctcccggcgc cccggcttcg ccctggcccg
    14701 cgcggccgcg cccgccctgc gtccgctgat gcgggccgcc gcgggccggc tgtggcggga
    14761 cgatctggcc tacgccgaac gccgctggca cctgcgcacc agcggccggc atccgggctg
    14821 acaccgggct gcgggccgtc gcccggcccc gtcgagccgc tgctcgcagg cccgccgcct
    14881 ggaccgcagc gcgtcccggt caccgcccgg cccgcccggc cgcccaccgc agggccgctg
    14941 accgcccccg gtccggcacg gtccacaggg tctggccgcg caggccccag cgtgccaaca
    15001 gcgcgttcgc cgcgaggaat ccggtcgtcg cggcccgctc catcagcgcc accgggaacc
    15061 cggtccgcac cgtgtcgccc gcgaccacca gccgggggtc gggggtgtgc acggtgggcc
    15121 ggtcgtggaa gccgcccacc gggaacaggg ggcagtccgc ccgccactca tggcggcggt
    15181 cgatgatccg gacaccgcgg gtctccgggt agacggcgtt caactgctcc accaggcggc
    15241 gctgttcacg ttcccggtcg gctcccgggg cgacggcgta ggcgtgcagt tcgagcaccg
    15301 agccgccggt acgggcggac caccgggccg cctcgccttc ccagcgctcc agcacgctga
    15361 cattgtccag ggacccgaaa ccgctggtgc ccaggaaacc cggccggtcg gcggccaccc
    15421 gacgcgccag ccacagccgc gacaccagga acggcggcgc cgtccgcagc cgcccgatcc
    15481 gcgcccgcca ggcggcatcc gccacctcgg gtgaggcggc gacgagccgg cgcagcccgc
    15541 ccgggtccag cgccagcacc accgcgtcga accggcggtc cgcaccctcc ccggccgcga
    15601 cccgcatccc accacccgcc accggcgcga cccgcgtcac gtccgtgccc gtgcacaacc
    15661 ggacgccgtg cccttccaga taccggccga ggggctgcca cagcgcctgc ggaaacggct
    15721 caccgggcac atcgaacagc agcccctcac tggagccgag gaagtagatg tggaacatca
    15781 acaccagctc cgcggccgac agttcccgcg ggtccgcgaa gaagctccgg gagaagacct
    15841 cgaacgcgag atgacgcgcg gcctcgggaa accggatacg ggcgaggaag tccgcggcgc
    15901 tgacgcggtc caggcgctga tagacctgcg gcacccgtac gtccagcagc ggcagcgcgg
    15961 cgccggggcg catccgtacc aggtcccgcc aggtgaagct gggactgagc gccacgaagc
    16021 ccagtgcgct ccagggtggt gtccggggca cccgggcgaa gctgtcccgc aggcccgacc
    16081 ggtggtgcag cggatagtcg ggcagccgtc tgagcatccc cagccccggg tcgacccgac
    16141 gcagcagccc ccgcaggttg tagtactggg gaaagaacgc atggaagccg cggctcatgg
    16201 tcgccgccga accgtcggcg agccgcaccg gccagcccgc cagccggccg ccgaggactc
    16261 cggcacgttc gtacagcgtc acccgcaccc cgcgctcggc cagcgcggtc gcggcggaga
    16321 ggcccgcgat cccgccgccg accaccgcca cctccggacc gccggccgcc gcccggtccc
    16381 gccccggtgg ccccggcacc gtccgggccc gccggtcacg tccacgtcgc gcggccccgc
    16441 cgtcatcgtg tcgaggtgtc acgccccctc ctcgcgggcg ccggccgtgg cggcgacgaa
    16501 ggtgtgggtg ataccggtct gccagccggt cagcggcagg gcccgcacct gccggaagcc
    16561 cgcccggcgc agccgcccgg tgaactccgc ggcggtgtcg aacgcgagga cgctgcgcca
    16621 cagatggcgg tacagtccgg cgtcccccgc gagccgcccg gccggccgca ggacgccggt
    16681 gcacaccgcc gtccacacgg cgcggggcac cgctccgccg gacagtgagt actcatgaac
    16741 ggccagccgc ccgcccggca ccagggcctc ccgtaccgcc ccgaggaccg cgtccgggtc
    16801 cgtgacattg cggaacaggt acgcggcgaa gacggcgtcg aagccaccgg ccaccccggc
    16861 gtcggccagc cgttccaccg gtgcgtgcac gaaggagacc ccgggcggcc agggcttgcc
    16921 ggcggcccgc gccagcatgc cggccgaggc gtcgacggcg gtgatctcgg catgcggggc
    16981 gacggcgagc agcgccgccg tcgaggcgcc ggtgccgcac cccagatcca gcacccgcag
    17041 tccacggccc gcgcgcggca gccccaaccg ccgggcggaa cgccgtagtt ggccgtggta
    17101 gccggggttc accgcgacca gccggtcata gctgcgggac gcatggtcga aggcggcggt
    17161 cagttcgccg tcgtgcagca gggccatgga tgtctcctcc ggtgacgggg cgagagcggg
    17221 cggggtcacc gcacggtggt gcggcggggc agcagcggga gttcggcgac ggtgcggagc
    17281 atgggcagca ccggggtgcg caggccgatg ctgacgtcct cccacagccg ggagcggccg
    17341 tcgaggaacc gcagcagccg ctccatcggc accgtgcgga acagcccggt gaagaactcg
    17401 gcgccgtcca cccggccgct gtccagcgcc cgcagcagca cggcgtccat cgcccggtgc
    17461 caggcgttgt gcgggggagg gggcaccgga ggacggccgg ccagcagcgc ggccgcgatc
    17521 agcgccgtct gccgctgcac ggaagcgaag gtgtacccgg tcgacggacg ggtggcgccg
    17581 ccggcggtcc cgatccggaa caccgcccgg cccacccggc gtgggaagcg gccgtcggtc
    17641 atcgggatcg cgccctgctc aacggccgtg acacggaagg cacccagccg cagcacctgc
    17701 ccggtgtagt ggcgcagggc ccgctcgtag gcggcggtgg ccacggtgcg ccgggagaac
    17761 tccgtgtact ccaccagcgc cgcacagtcg ttgagcggca gcacataccc gaaggacaga
    17821 ccgtggtcgg gctgcggggt acggaagtcc atcagatccg cgaccgtggg gtcgaacgcc
    17881 gggcgccggg tgcggacgaa ccagccccgg aagtgctgct ggagggtggt ccgcgccgga
    17941 gggagccgcc cggccggccg ggagtcgaag gcccagcggg cccggagggc caccggccgc
    18001 ccggccgcgt cgtgcccccg cacctcggcc ccgccggtga cgtcccgtac ggactccacc
    18061 gtcgcctcgg tccggaccac ggtgtcctgt ccggcgagcc gggcggccac cagggcctcg
    18121 aagtcacgcg accgcagcat cttgtaccgg aagggctcgg gccgccccgc cgtcgcctca
    18181 ccgttgggcc cgtgcacccg cagccgttcc cacgacgcgg tcagggcctg gtcgaacgcg
    18241 ccacccggcg cctcccagta acaccaggtc cgctccggcg gggtgagcgg cccccgcggt
    18301 gcgtcgacca gcaccacccg cagcggccgg ccgccggccg ccggtgcgca cagccggtgg
    18361 gccagcgaca gcccggccgc tcccgcgccc acgatgacgg catccgcgtc ctgcacgccc
    18421 ggtcctctcg ccgcccgatg cccccgcgac gatctttccg cagtcccggg ccgggaggcg
    18481 gcatccgacg cgcgggaatc cggggcgcgt tgtgtccgcc gccccgggtg cggttccttg
    18541 gcgggcgtcc gcaagaatcc tctcccgacc aatccaggtg tcgcccggcg ccgaatcact
    18601 cgtgaccacg tcacgtaacg gaggtgtcca tgcccgtcgc agcccgcggc gaccgatccc
    18661 ccgcaccgca taccggtgcc ctggaaaccc tgctcacccg cgtctcccgc ggcgaccagt
    18721 acgcgttcga gagtctctac acggcggtgg ccggctccgt actgggcctg gtgcgccggg
    18781 tggtacggga tccggcgcag tccgaggagg tcgcgcagga ggtgctgatc gaggtgtggc
    18841 ggtccgcggc ccgcttcgac gcacggcagg gcagcgccat ggcctggatc atgactctgg
    18901 cgcaccgtcg cgccgtggac cgggtgcgct ccgtccaggc ggcggccgac cgcgaccacc
    18961 gggccggcat gggcgcctac accgccccct tcgacgaggt cagcgagcag gtcgagcggc
    19021 ggctggagcg cgagcaggtg cgccgctgcc tccagcaact caccgacctg caaagggagt
    19081 cggtgacgct cgcttattac cgcggctaca cctaccggga gaccgccgat ctgttgggcg
    19141 ccgcgctggg cacggtcaag acacgactgc gggacggact catccggctc cgcgactgcc
    19201 tgggggtgtc ggcatgagca ccgtcgatct gcacacactg acgggtgcct acgcactggg
    19261 cgcgctctcc gagcaggagt ccgccgagtt cacccgccat ctggcgcagt gcccggcctg
    19321 cacccaggaa gtgcgggaac tccaggagac cgcggcccgg ctggcgctgg ccgtggccga
    19381 ggtgcccccg gccgggctgc gcacccgggt gatggccgcc ctgcccgagg tcaggcagct
    19441 gccgccgagg gggcgccatg cgaccgcgac cgtggtcccg ctgcgccggg gcatacgctt
    19501 ccggctgccg tacctcgcgg ccgccgcctg tctggtggtc gccgccctcg ccggcgggct
    19561 ggccgtccac gcccggaacg aggccgacca gcagcgggac cgcaccgtcc gcgccgagca
    19621 gcaggccgcc gcggtcagtg ccctgatgac cgccccggac gccaccttcc acaccaccgc
    19681 gctcaagggc ggcggcagcg gcaccgtcgt cgcttccaag cggaggggcc agaccgcctt
    19741 cctctaccac ggcctgccgg cgctctccgg tcagcgggtg tacgaactct ggtacagccg
    19801 caacggcgcg atggagcccg ccggactcgt gcggaccggc agctcctccg gcgcgatgct
    19861 gctgaccggc ggcccccagg gcgcggacgg cgtcggcgtc acggcggaac ccccgggcgg
    19921 ctccagccgg cccaccacca cgccgctggc cgtcctccgg ctgtgacctc cggccccacc
    19981 ggatccgacc ccggccgccg gcccccgaca cgggccggcg gccggcccac gcggtcgcca
    20041 tgccatgcgg cggacacccc gtgctgcgtg acgcgtctca ctgacatcgg ctgaccgtgg
    20101 acctcgtcgc cgcccttctg gaggcacccc tgtgccccac gcgatcggcg gggtgcgccc
    20161 ggagtagcgc cccgaacggg tacaccgttc tttgacggcc ggtcagcctc gcccctgcgg
    20221 gcgggccatg acgcgttttt gtgccctctt gcctactcgg tgacacatga cggagacagc
    20281 gcgtacgtgc tcgccgcttt tcagtcaagt ggaacgctgg aaacgagcaa aagaggcaac
    20341 taactgacca gattgtcgcg tcttccgtgc agagtcataa gaaggggctt tccacccctg
    20401 ccccgtgcca ggggctcgga aaccggtctt tgaggagatg gaatgcgacc gtttgcgttg
    20461 agctacgccc gtccggcggc gaagtcatcg accagtacgc cgtacagcta cgacgccacg
    20521 cggcaactca acgtcctccc ggacggacgc ccggccacgt gcagccgggc ggtgctgctg
    20581 gccaccggca ccaccgcctc caccgccggt tccaagaccc acttcgacga ctgagcccat
    20641 gaccgtcctg gtcctgacct gcgaggaaga tttgacggcg gacatcgtgg tgtcgacgtt
    20701 gcaggacctc ggtgtcccgc tcgtccgcct cgaccccgcc gacctgcccg gccgggtcgc
    20761 cctgtcggcg gagtacgcgg acaacgactt ccacggatat ctcaagtccg gcgagcgcat
    20821 ggtgagcctg ggcagcctgc gttcggtatg ggtgcgccgg cccggtaccc ccggggcccg
    20881 cgccgcggaa cagtccgcct ggatcacggc cgaggccgag caggcgctct acggcatgct
    20941 gaccagcacc caggcgcgct ggatgaacca tcccgtcgcg gccgcgcagg cgcgctacaa
    21001 gccctggcag ctccggctcg cccaccgcag cggcttcctc gtgcccgcca cgctggtcac
    21061 cacgttcccg gcgatggccc ggcagttcgc cgccacccac caggacctgg tggtgaaatc
    21121 ggtgagcgga aagcaccccg gtgaccctcc gatggtgctg cccaccaccc gtatcagtcc
    21181 ggacacggac ttctccgggg tggcagccgg gccgaccctg ctccagcagc acatccccaa
    21241 ggaggcggat atccggctga cgtgtgtcgg tgaccatctc ttcgccgccc gtaagaaagc
    21301 cgatccggag gaagtcgaca gccgcttcgc ccaccagggc acctgggagc ccgtcgaggt
    21361 gcccgacgcc gtccaccggt ccgtgaattc ctatatgagt gctgcgcaac ttgcctacgg
    21421 tgcttttgat ttcgccgaag acccggacgg cgcctggtgg ttcctggaat gcaaccaggg
    21481 cggccagttc ggcttcatcc agttggagac cgaccagccc atcgcccagg ccatcgccac
    21541 ctggctcgcc gtggaaccct gaggccggag cggtggctcc gcccgcaccc cgccgcccta
    21601 gtggatcagc atgttcgcga tcacgatgag cagaccgatc agcacatcca ccccacccac
    21661 ccgaaaggac gccgcccagc gccggcccgc cacccgggcc gcccaaaccc cccagccgaa
    21721 cagcgccacc atattgatgg tcagggcgac gtcgaccgcg ccgtcctcac cccaccattc
    21781 cgcgtaggca ccgaacagcg cgaacatggt gggcaccatc gcggccacca gcggccactc
    21841 catcagcacc gaacgcaccg cgctcggggt gacgtgcttg tcgtcgctcg tccggtgcgc
    21901 gatcgagtgc gcgtagccgt gcgccgcggc cgacgccgcg gccgtcagcg ccacccacag
    21961 cgcgtcgtag cccgggtccg gcggtctgcc ctcatggccc agcgcggcca ccagcgcgct
    22021 ggcgagcacc gagccgtaca ccccgccgaa cagcagtcgc tgtaggggct ccgctcgtct
    22081 ggggggcggc tgcacgggta cgctgcggct ttctgacaag gcgccacctc acaggaccga
    22141 cgggcttccc cgctccggga tcaacccccg agatgtagca gcccccggcg ccgatccgtc
    22201 cgaagctgcg ccgacggccc cggcgattta ccaccgcgtg gcgcgccccg gtcagctgtg
    22261 cagcgtcagc ggcggatgcg tcccgttcag gtagtggtca ccgatgtcgc ggagccgggt
    22321 ggtgggggag acccgtgccg tcagtacccg ggcgttgcgc cagaacctgt cgaaacccaa
    22381 cgggtcggca gcggagtcgg cgccctgggt gagttccagg acgcgggtgg tcagacgcat
    22441 cgcgcagcgg ctggtgacgg cctcggcggc ggctaccagc accgcgatat cggcccgctg
    22501 gtcgaccccg agccccgggc ccgcgcggag cccccgtgcc agggcctccg acgccgactc
    22561 gacgacggcc gcggcggtcc gggtctcggt caccaattcc ccgtacgcga gaaggagata
    22621 ggggtccgcg cccggccgct ccgcgtaccc gtcctcgtcc ggcccctcgg ccgcccggcc
    22681 gtgcgacccg gctcgggtga tgtcccgggc ctccgccagc gctccttcgg cgatgcctag
    22741 accgacgtga acgagggcga gccggagcgc cagcggggcg agcgtggcga acggcgcgag
    22801 ggcgtgctca tcgcgcggga cggcgccgag cacctggtcc gcggggaccg ggacgccgtc
    22861 gaagctgatc cggccggccg cggtgagccg ctggccgagg cggtcgtgct cgggggcggc
    22921 cgccacgccg gggtgggccg ggtcgacgca gaccacgagg gactcgcccg tatcggtgtg
    22981 caccgcaccg agcaccagcc ggtcggcgac ggccacgccc gcggcgaacg accggcatcc
    23041 gtggaggagg tatccctccg cggccggggt gagggtgagc tccggcccgg tcgccggttc
    23101 ggggtccggg aagtcgatac cgccgcccca gagccactgt cccgcgctcg cccggagttc
    23161 gagctcgtcg gcccgttccg gggtgccgaa gaagcgtgcg ctccacgaca acgcccagtg
    23221 gcggcccagc agttcgccga tggaaccgtc cgctgccgcg atctcccgga tgaccgcgca
    23281 ggcggtgcgc cagtcggtgc cccgcccggc gggtccgggg ggcgcaagca gcgccggcag
    23341 acccgcctcg cgcagccggg cgagctcgtc gaacgggggc ttgccggccc ggtcgcggac
    23401 cagggcgtcg accgccaggt catcggcgac ttcccgggtg acgcgccgcc agatctcgtc
    23461 gtcggtacag gacttgacgg gcggggaagc ggggcgtgcg ggggacttct ccggcatggt
    23521 gacctgcctc gtcccggccg tgtccggtgc gggcgggcag atcaggccgg cggccgacgg
    23581 gacggaacgc atcggtgcgg gcacgcccac ctcctggctt ccctagtttt cccactggat
    23641 tggtagggaa agaatgcttc cagggccgtg gacggatcaa ggggcgttca agggatggac
    23701 aagcgcgtct tggcatacgg gacatggtcc ggacgcgccg cgctccggac gcgcctcgct
    23761 ccgaacgaca tccgttaggg attcgtccag gactcgggat gctcggtcag ctccgccacc
    23821 tgcggcggca gctcggcgga ggcgacatcg gccagggtca cgccgtcgag gatttcgcgg
    23881 acgttcgccc gcagcgcgat ccacagcggc agcagggacc gggcggggcc ggtgtaggac
    23941 agctccggcg ggcggactcc gcgtaccgac accagcggtc cgtccacgac ccggatgaca
    24001 tccgcgatgc tgatcgcctc cgcgggcctg gccagccggt agccgccgct gccgccgcgg
    24061 cggctctgca ccagcccgcc ccggcgcata tcgttcagaa tgccttcgag gaacttgtgc
    24121 ggaatgtcct gggcctgggc gatggcctcc gccttgagcg gccccgcgtc ccgggcgtca
    24181 gcgagttgca gtgcggcacg cacggcatag tccgctctgg ctgagatccg catgctccgc
    24241 attatcccgc agcggacccg gcatcccgca gggggcccgg cgcggatccg ccgggtgccc
    24301 gggcgccggc cgcccggcac gtctccgccg tccggttgcg agcccggacg accggacgga
    24361 ggctcgacat acggcatgga ctcacggcat cgactccgag gtgagtgtcg tggcagacaa
    24421 aggcgcgccg atacccgtca cccagcccgc cgtcctggag acgcgagggc cgggcagcgt
    24481 gaaggtggcc ctcgacgtca acggtgtctc ccgggtcgtg catctggaac cacgggtgag
    24541 cctgctggac gcgctgcgcg agcagatggc cctcaccggc tccaaaaagg gctgtgacca
    24601 gggaacctgc ggtgcgtgca cggtctgggt cgacggccgc cgggtgctgt cctgtctgac
    24661 cctggccatc agctgcgaag gccgggaggt gaccaccatc gagggcctcg ccgagggcga
    24721 tgagctgcac ccgatgcaac gcgccttcct cgaacacgac gccttccagt gcggctattg
    24781 cacgccggga cagatcatgt cggccgtcgc gctgctgaac gaaggacatg ccgggaccga
    24841 cgcggagatc gccgagtgga tgagcggcaa catctgccgc tgcgcggcct atccccctat
    24901 ccgctccgcc atccgcgagg tgcgggaccg gaagacagga cagtgaggtg cgtgccatca
    24961 gctacacccg cgcgacggac gtgcacagcg ccgtcgaggc ggtgacgagt gaccccggca
    25021 gttccttcct cgcgggcggc accacggaaa tcgatctgct gcggctggat gtgctgcggc
    25081 cgcatcgtct ggtggacatc aaccggctgc cgctgaccgg cgtcgaggag cgtgccgacg
    25141 ggggactgct catcggcgcc ctggcccgga tgagcgaggt cgccgaggac cgagcggtcg
    25201 tggagcgctt cccgatgctg tcccaggcac tgcttctcgg ggcctccgcc cagctgcggc
    25261 acatggcctc catgggcggg aacctgatgc agcgggtgcg gtgcgcctac taccgcgacc
    25321 ccgaatcggc ctgcaacaaa cgcgttccgg ggagcggctg ttccgcactg gagggcgtcc
    25381 accgcggcca tgcggtcctc ggcacgagcg agcactgcat cgccacccac ccctccgacc
    25441 tggccgtcgc cctcgtcgcc ctggacgccg tggtgcacgt ggaaggcatg gacggcgccc
    25501 gcaccatccc cgtcgacgac ttcttcctgc tccccggcga tacgcccgag cgcgaacacc
    25561 cgctcacgcc cggcgaactc atcaccgcga tcgaggtgcc cgcgctcccc atggcgcgca
    25621 gatcgctgta tctgaaggtg cgcgaccgtg agtcctacga attcgccctc gcctcggcgg
    25681 cggtggcgct cgcgctggag gacggagtgg tccgcgaggt ccggctcgcc ctcggcgggg
    25741 tggccaccaa gccgtggcgc gcccgccggg ccgaggacgt cctcgtgggc gagcgcgccg
    25801 acgacgccgc gttcacccgg gccgcgaccg ccgaactggc ccccgccgac acccggccga
    25861 tgaacgcttt caaggcggaa ctcgcccggc ggaccctcgt ccgcgccctg cgcaccgttg
    25921 ccacgaccgg aggcgggacg gcatgaccac cggcgccacc ctcgaagcca tcggccggcc
    25981 cgtcgatcgc gtcgacggtc ccgccaaagt caccggacac ggccgctact cggcggagat
    26041 caccctgccc aacaccgcgt acgccgccct ggtcggcgcc cgtacggcca gcgggcggat
    26101 caccggcatc cgcacggagg ccgcggagcg cgccgacggt gtactcgccg tactgaccca
    26161 ccagaacctg ccgaaaatcg ccggccggcc cgctctgctg ccgtccctgg ccggccatgc
    26221 cgccccgggg gagagcttct tcccgcttca ggacgatgtc gtccactact tcggtcagcc
    26281 cgtcgccgtc gtcatcgcgg actcgctcga acgcgcccac ttcgcggccc ggcagctcca
    26341 tgtcgactac gaccggcgtc cgtccgtcac cactctggac gagggccggg accaggccta
    26401 tgaacccgag gcgatcttcg ccgggttcct tcccgcccgc agtgtgcgcg gcgatgtcga
    26461 agccggtttc caggccgcga cccaacgcct cgatgccacc ttccatttcg cggccaacca
    26521 ccacaacccc atcgagccgt cggccaccac agccgtctgg gacggcgacc ggctcaccct
    26581 ctacgacgcc acccagggca tcgtggcgac ccagagcacc gtggccgcac tgctgggcat
    26641 cccgccgtcg aaggtacggg tccgggcgtc gttcgtcggc gggggattcg gctgcaaagc
    26701 catgatctgg ccgcatgtca ccctggcggc gctggccgcg cgggaggtgg gccggcccgt
    26761 caaactggcg ctcacccggg agcagatgtt cacctcctgc ggccaccgcg aggagcagga
    26821 acagcgcatc gaactcgggg cgaccgacga cggccggctc accgccctgc gccaccacaa
    26881 gctctcgctg acctcgccct tcgacgaatg ggccgaaccc tcgctcggca tggccggcca
    26941 ggtctacgcc tgcccccact acgagggcgt ctaccggctg atccgcagca acaccatgac
    27001 acccaccttc acccgcggcc ccggcgagac cacgggcatg tacgccatgg aatgcgtgat
    27061 ggacgagctc gcccaccgca tcggcgtcga cccggtgcaa ctgcggctgc gcaaccacgc
    27121 cgaggccgac ccgcacaccg gccacccctg gtcgagcgac ggtgcggagg agtgctaccg
    27181 acgcggcgcg gcccgcttcg actggcagtc gcgcaacccc gaaccccgct ccgaacggga
    27241 cggcaaccgg ctcatcggca agggcatggc caccgccggc taccccgtgc tcttccccat
    27301 gcagccgcag cgtgcccggg cccggctcta cgccgacggc accgcggtgg tgcaggccgg
    27361 cacccaggag ttcggcaccg gagcgggcac cgccatgacc caggtcgccg ccgacggcct
    27421 cggcgtcgcg ctgcggaacg tccggttcga gtacggcgac accgacctgc ccaacgtcgc
    27481 ggccgcggtc ggctcggccg gcgccggaat gatcagcgcc gcggtgtaca cggccgccac
    27541 cacgctccgc gaccagatga tcgagcaggc gatcgccgac cccggctccc cgctgcacca
    27601 ggcggaccct gccaccgtcg tcgtccgcga gggccggatg cagctgaggg accggcccga
    27661 cacgggggag agctaccgct ccctgatggc gcgtcacttc atgaccgacc tggaggcact
    27721 gggcagctgg agcccgccac cgcaggatct cccgtacggg ctggccacct tcggcgccca
    27781 gttcgccgag gtcgccgtcg acccggacct cggtacggtc cgggtgcgcc gtatggtcgg
    27841 tgccttcgcc cccggccggg tcctcaacgc caagacggcc cgcagtcagg tcgtcggcgg
    27901 catgctctgg ggcctcggcc aggcgctgct cgaaggcagt tcgaccgacc cccgcgacgg
    27961 ccgctgggcg aacgcgagcc tcggcgagta cctggtgccg gtcaacgccg acgcccccga
    28021 cgtcgccgtc gagttcgtgg aagtgccgga caccgtcgtc aacccgctcg gcgtcaaggg
    28081 cctcggcgaa gtcggcatgg tcggcgcggc ggcggccatc gccaacgccg tcttccacgc
    28141 caccggatac cgggccaggg aactgccgat caggatcgag cacctgctgt aggggcgacc
    28201 ggcccgccgg cgaaggaagg acgtcaccat gcccacggac gcacaccccg gcccgctgcg
    28261 ggtactcgtt ctcggtgcct cgatgcgcac cggatcgacc aacgcccgcc tggcctccct
    28321 tgtggcccgg atggtgacca cggccggcgc caccgtggat ctcgccagga tgcgggaatt
    28381 cgacatgccg ctgtacgacg gtgatgtgga ggagac
//
