LOCUS       NZ_BBNO01000007        24511 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000007
VERSION     NZ_BBNO01000007.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 900839)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 111651
            Orig. end                         :: 136162
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24511
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24511
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24511
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14511](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14511)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(897..911)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     misc_feature    1378..1392
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    2292..2305
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.34"
                     /tool="antismash"
     gene            2576..3718
                     /locus_tag="TU31_RS23030"
                     /old_locus_tag="TPA0598_07_00980"
     CDS             2576..3718
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601852.1"
                     /locus_tag="TU31_RS23030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_00980"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_042157856.1"
                     /transl_table=11
                     /translation="MHPTRKAAVTAAALLVMATSAGCEPGAGATASHRDSAAEPGCPTV
                     LSKAKQAVKKAEEVNAPWRGPTTGPKAVHGKSVVYIAQTLTNPGVAGVAQGVQEAAKIV
                     GWHARTLNGQGTPDGLRAAFKQALRLKPDGIVISGFDPGIAPAEVKKANSAGIPLIGWH
                     AAPAPGPSKDPKLFSNVTSRVEDVAKISADWIIARSNGRAGVVLFTDASVPFAKRKSDL
                     IKKELATCSGTKLLSYTNMPIPEVNRRSIKEVRSLLSRFGRKWTYSAAINDLYFQHAAP
                     ALRAAGKDGAGAPFNIGAGDGDPSAFQRVNGKQFQAATVPEPLSEQGWQIVDEFNRAFT
                     GAPDSGYVAPVHIATATNSGGALSWDSEGYRQAYRKIWGD"
     gene            complement(3776..4447)
                     /locus_tag="TU31_RS23035"
                     /old_locus_tag="TPA0598_07_00990"
     CDS             complement(3776..4447)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317456.1"
                     /locus_tag="TU31_RS23035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_00990"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_078885914.1"
                     /transl_table=11
                     /translation="MKSHARKSQPTASRGRLIAAAVALLAVVASVSVWLAQRNSSADES
                     HSAHLPAANAAPAGPQGGNAGPLSALDKTFLTKVRQAGLWEMPAGRLAQTHASSEAIKR
                     AGMHLLEGHSKLDQLAREDSEALSVPIPDEASAEQQGWVDQLKDARGKAFDQLFVDLLR
                     ASHGKIFITIGEVRATTKNTLIRRLATQTNNTVQDHMDVLEDTGLVTEATLDDVASTIP
                     K"
     misc_feature    complement(4517..4528)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.98"
                     /tool="antismash"
     misc_feature    4525..4537
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            4710..5204
                     /locus_tag="TU31_RS23040"
                     /old_locus_tag="TPA0598_07_01000"
     CDS             4710..5204
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326895.1"
                     /locus_tag="TU31_RS23040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01000"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_042157859.1"
                     /transl_table=11
                     /translation="MAERMAPTRGRDDVDAVTQAVLTASRLLVAVSARSLGEVEERVTL
                     PQLRMLVVLSTRGATKLVTLAELLQVAPSTAMRMVDRLITAGLALRQANPDNRRETLLR
                     LTDEGRRTVEEVTARRRAEISAIVERLAPAQRASLIEALTAFNEAGGEPPVDAAEAHPL
                     G"
     gene            5420..5764
                     /locus_tag="TU31_RS23045"
                     /old_locus_tag="TPA0598_07_01010"
     CDS             5420..5764
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040404.3"
                     /locus_tag="TU31_RS23045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01010"
                     /product="hypothetical protein"
                     /protein_id="WP_042157862.1"
                     /transl_table=11
                     /translation="MQITIRCEGADSAGELAASLHQWLLDEPDARRHAEVRLVGAAPVE
                     GELGFVLDLVQLVVSSGFSAGSLGYTVAQWKKMNAPQLAMSFERNGRTVTVSGTDAEEI
                     ARAIRQLDEE"
     gene            5769..6779
                     /locus_tag="TU31_RS23050"
                     /old_locus_tag="TPA0598_07_01020"
     CDS             5769..6779
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012862.4"
                     /locus_tag="TU31_RS23050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01020"
                     /product="caspase family protein"
                     /protein_id="WP_158894609.1"
                     /transl_table=11
                     /translation="MARLPRFDASYALLIGVSEYQDHEFPEVPAAIHNLAGLRSVLAPS
                     DGGGFPREKCRMVSNPRTGEGMRVAIKRAAESATDVLLLYYVGHGWKVDGDLYLASQSS
                     SPDSIETTGLAYKTVRRLVRSSPAAIRIIVLDCCFSGVATGLLSGTGDLRLREPEVEIL
                     LDEELPDDHADGVCVIASSGPNQPSQDSDGADHTAFTGHFLATLKAATQAGEVRDLETV
                     FDGTKAAMVSAELRHAPLIASMGGARRLALVKSLTAVDPVPVPVPVVVPEAAVVRPPTA
                     ADEAVAAAAVAPGDGPAKLMSWHTPVGSADIFDSALALTLLQQAMAMGGDDEHAG"
     gene            6763..7902
                     /locus_tag="TU31_RS37045"
                     /old_locus_tag="TPA0598_07_01030"
     CDS             6763..7902
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040332.3"
                     /locus_tag="TU31_RS37045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01030"
                     /product="trypco2 family protein"
                     /protein_id="WP_107070734.1"
                     /transl_table=11
                     /translation="MSTPDRKRSGELDRLRVQAEEDFRTYGPQLADRLLTACQRLRATG
                     EGEEALLIAQEAVGIHRELLDRYHCVGTGLAHALLQLGLCLAELGAAEEAVDVLQECIA
                     LSDVLPAPLRPPALRLRCNALECLALILGSSDRTAEAVAASHLAITGYRELYEEDPSVA
                     PELARGLHNLATLLASGAEWEQALVPLEESLAMYEQLSAGGKTALAAERSRAQQLHAVL
                     AGGEGDAGEVAGEALSAYHLAAEADAYSATSGLAGIPAHVEISRVEPADHVAQPHREQR
                     SMDLNRIDLTEAVQAVRDDLRAATESFDGGDLQFDMGPIELEFTVELERDPRARSGVRT
                     WVVTDAGTGRVSAPARHRLTLTLTPRQVAYRSVDVANRM"
     gene            8013..8630
                     /locus_tag="TU31_RS23060"
                     /old_locus_tag="TPA0598_07_01040"
     CDS             8013..8630
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020575914.1"
                     /locus_tag="TU31_RS23060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01040"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_042157867.1"
                     /transl_table=11
                     /translation="MRLTKYTHSCVRLERPGGGALVIDPGVWSEARALHGADAILVTHE
                     HADHVDVLRLKGIGAPVYAPRGADFGGLLDVIEVEPDEEFSAAGFHITAHGGRHARIYG
                     DLPDCANLGYLIDERLYHPGDSLHVPEKPVETLFVPVQASWLRTSEAIDFVRAVKPERA
                     YGIHDAQINERGLHSVNGWLDEEAGGCYRWVPPGASLPCSER"
     misc_feature    8610..8612
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8802..9575
                     /locus_tag="TU31_RS23065"
                     /old_locus_tag="TPA0598_07_01050"
     CDS             8802..9575
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088660.1"
                     /locus_tag="TU31_RS23065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01050"
                     /product="DUF72 domain-containing protein"
                     /protein_id="WP_042157870.1"
                     /transl_table=11
                     /translation="MTVLVGTSGWQYKDWREVLYPRERPQRLWLEEYARHFATVESNAA
                     FYRLPEEKTFADWRDRTPDGFVMAVKASRYLTHIKRLREPQEPVGRLMSRAAALGPRLG
                     PVLLQLPPTLKADAGLLDDCLSCFPAGTRVAVEPRHPSWWTAEVRTVLERRGAALCWAD
                     RGSRPVTPLWRTTDWGYLRFHEGRAEPWPRYGRQALTTWARRIADTWPDRADVYTYFNN
                     DPGGAAVRDATTFARAVTARGRTVSRAPSGRGAAR"
     gene            9646..9930
                     /locus_tag="TU31_RS23070"
                     /old_locus_tag="TPA0598_07_01060"
     CDS             9646..9930
                     /EC_number="3.6.1.7"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088661.1"
                     /locus_tag="TU31_RS23070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01060"
                     /product="acylphosphatase"
                     /protein_id="WP_181018647.1"
                     /transl_table=11
                     /translation="MIRRRVVVSGDVHGVFFRDSCRRTADGLGVAGWVRNLPDGTVEAV
                     CEGEPERVRRLVDWAHEGPPLATVDAVSVREEEPEGLTGFEIRPTPAGF"
     gene            complement(10001..11404)
                     /locus_tag="TU31_RS23075"
                     /old_locus_tag="TPA0598_07_01070"
     CDS             complement(10001..11404)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="TU31_RS23075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01070"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_052719017.1"
                     /sec_met_domain="LANC_like (E-value: 2.7e-38, bitscore:
                     127.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHALCDAASDLAYRVADLLSSPEQVARTAHQALAALPPELSQ
                     PAWQPASLLMGHPGIALLHTRCARNDARYAAIGHAHLAAAVAATTGAGPATVGDLLLPA
                     RLHADAHGGYTRLLARCAEVHAAYVQAHVARLEARRQADGPGLAADDYDVISGLAGEGR
                     GLLLAADHGDERCAQVLHDVLAYLVQMTHPVRPPAADGSHVPGWWCAPDRYLLPRDREE
                     YPRGDFNVGVAHGICGPLALMSLAHRSGHRVPGMADALRRMADWVVSVGHTDDLGMRWP
                     GRVAPAEDAGEPAHPSQERRPPREVGARSRPGWCYGTAGIAWSLYLAGRALGDRRLTAL
                     AEDAVSGLVRRPLDAAVSTDPGFCHGRAGVLHTVSRMAVATGRTEWWARADGLARELVA
                     ECDPRTPFGYRQVVPPSPASGSAPYRVHHPGLLDGAAGIALVLAEYADARRGVVVAEVN
                     GWDAAFLMG"
     gene            complement(11401..14511)
                     /locus_tag="TU31_RS23080"
                     /old_locus_tag="TPA0598_07_01080"
     CDS             complement(11401..14511)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="TU31_RS23080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01080"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_158894612.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.7e-178,
                     bitscore: 587.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.3e-14,
                     bitscore: 47.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.6e-38, bitscore:
                     127.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALVRAAALPLPSDDPPASASLPSGEVTDEEARLHRRIAELAAEP
                     RLMTALSLASASLAEEVDRAVAGEPLRLKSLRRIALSLTKYRSRMSHRPTPFGLFAGVG
                     LAGFGPAPAREPLGAGRTVTRPDAAWLDGVLETLRDVPAVLERSRLTANNLHTVRDGRL
                     VLVDHHDPTGERQLAGSVRHTRVVQVLLAAAARTTPFPRLVEEGRRVFPHAPEGAVEGS
                     ITQLVRGHFLLTDLTPPPDCTAPLDHVRDRLHGVDHPTARELCAIQAELSTLDATSPGS
                     RRARLTAVSARMRALDPAPDVLQTDLSLDLRLTLPSEVAREAAQAATVLWRTSPVHRGT
                     PHLRDYHLAFLEKYGTDRAVPVLELLDEARGLGLPRAYRQPGAVPSPESGERDRVLGEL
                     LMDAARSGVREVVLDEETVRALEPAERGPAPLSMEVGAELVAPDWEALCAGDFRLVLAP
                     QAVSPLAGAMFSRFAPLFGPSGTLIQDLALHAERSAPDDEIPACLAYRPRVARSANVSA
                     VPQWLSHRIPLGAGPAAAETAHDLRLENLAVHADRDGLRLVDGTTGRRVRPLSYSMLNP
                     ANGHLPYVARFLLELGQEGRSFCAPWSWGRWASAPALPRVRHGRTVLSPARWLPDRALR
                     AAADQGDEEWGEQVGRWRRRWDVPRRVLLARGDHRVAVDLDDPLHLPVLRDEVRRAAGL
                     TLVEQCGGRAERQWFRSAEGPHAAEFVFPVFARPDGRGAAPGTRQARPATAPVPLLLDG
                     PDGGRGARTHLPGGEWLYAKLYVPPARQPEVLARHLGALTDPELLRSAGADHWFFLRYE
                     DPAPHIRLRFHGTPESLWPVLLPALHSWARERAAAGLLGTVGLDTYEPEVERYGGPAAL
                     GHAERVFHADSESVVTLLAMAPDQLGDPTLPAALGILDILTRLGTPDEALDWLSGPSVL
                     ERRGEVPRSRKQQVAALLDAHARPGPPAAADGWGVGWSTRGPALAGLREVLSAGATDRD
                     RTARIALSLAHMHCNRLLGPRPELERTAQVTAREALALWLGRRRNNR"
     aSDomain        complement(13795..14061)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_TU31_RS23080_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="2.90E-15"
                     /identifier="RREFam001.1"
                     /label="TU31_RS23080"
                     /locus_tag="TU31_RS23080"
                     /protein_end="239"
                     /protein_start="150"
                     /score="47.7"
                     /tool="antismash"
                     /translation="TANNLHTVRDGRLVLVDHHDPTGERQLAGSVRHTRVVQVLLAAAA
                     RTTPFPRLVEEGRRVFPHAPEGAVEGSITQLVRGHFLLTDLTPP"
     gene            complement(14642..14785)
                     /locus_tag="TU31_RS38750"
                     /old_locus_tag="TPA0598_07_01090"
     CDS             complement(14642..14785)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS38750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_07_01090"
                     /product="hypothetical protein"
                     /protein_id="WP_158894616.1"
                     /transl_table=11
                     /translation="MENVTINLDEFDLDLDMEIMESATTAVKAQDSKLMTQVCRPTTWH
                     CG"
     gene            complement(14982..16130)
                     /locus_tag="TU31_RS23085"
                     /old_locus_tag="TPA0598_07_01100"
     CDS             complement(14982..16130)
                     /EC_number="1.3.1.98"
                     /GO_function="GO:0008762 - UDP-N-acetylmuramate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF010478.0"
                     /locus_tag="TU31_RS23085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01100"
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="WP_275451852.1"
                     /transl_table=11
                     /translation="MRRRGTASCSSPTEGRSSPPRPLPRHDPSTRNGIQEKQEHMRVTH
                     EVPLAPMTTLGLGGPAAVLFELFDPADFPEFVALADASPGRPVCLGEGSNVVVSDAGCE
                     GAVLRMSTKGVRMTGRTDEGRVLVEVQAGHLLGDLVDTTVAEGLTGMEMLVGIPGTTGA
                     TPVQNVGAYGQETADCLVEVTAWDWELGRMVTLDAAACGLGHRTSVFKHSRRWTLLNLV
                     FALRPSELSAPVTYRTVAAALDVPLGSRVPLNEVTQAVLAVRRSKGMVLGCSGTDDRSV
                     GSVFLSPEITPAQADGLRARNAPVNHFPDGSTRVSASWLIRQAGFELSTPIVTGVRISS
                     LHYTLVADEGATAAGFTRAIELVQQEVLRRTGVRLTSELDFL"
     gene            complement(16203..17510)
                     /locus_tag="TU31_RS23090"
                     /old_locus_tag="TPA0598_07_01110"
     CDS             complement(16203..17510)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601817.1"
                     /locus_tag="TU31_RS23090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01110"
                     /product="hypothetical protein"
                     /protein_id="WP_042157875.1"
                     /transl_table=11
                     /translation="MNDTSVLATCLARLSWPPERLAREINRRCGNGTISSKAPYNWLKG
                     ACPRRRLPYIIATILSDHLGEPITVEALWPGHFASAVPPQRRSAAQPRPAAPVQRPAAL
                     DPLTASVDWLVDDDALPPPSRLRGEEIPGVAIEMLTARIQQLRQLDDSGSSGLVLDWAL
                     QDLQWAERLAAKYSYDASTGRQLHRIIAELGQLTAWLTADQGQDELSNSRFLAALGAAR
                     AAGDRPLAAYIISCMSYRAGWAGRAEEALRLIRIARKGSAQEDMGIGHALLATREARAH
                     ASLGDEAACQRALDDAAELSRAGRPSAEPLWAYWLTPAVMVADAGRAWLELGRPKRAES
                     YLTRGIDMLQGSQPRNLLLHSASLAEARLARCELDGAVAAATDALALAEHVSSQRAHAR
                     LMALRRRFVRYDSAVARDIVQRADDLLAAGRARAVC"
     misc_feature    complement(17490..17492)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17715..17730)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(17729..17747)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    17732..17750
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.39"
                     /tool="antismash"
     misc_feature    17735..17751
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.69"
                     /tool="antismash"
     misc_feature    complement(17736..17754)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.18"
                     /tool="antismash"
     misc_feature    17740..17758
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.46"
                     /tool="antismash"
     gene            complement(17787..19073)
                     /locus_tag="TU31_RS23095"
                     /old_locus_tag="TPA0598_07_01120"
     CDS             complement(17787..19073)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088667.1"
                     /locus_tag="TU31_RS23095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01120"
                     /product="MFS transporter"
                     /protein_id="WP_042157877.1"
                     /transl_table=11
                     /translation="MEPRGRTRWAIGGLLAGGIVVNFLDRTAISVASSSIADEFGLDLQ
                     QLGVVLSAFTWSYCLVQLPAGMLVDLLGVSRLTRIASALWAVAGLLTAVAGGVGPIILA
                     RLLLGVAEGPSMVGASKATAAWFPVSERGMATALFDGATKLANMVAFPVLAFVMSEWGW
                     RAGFLFSAAVSVLFTAVWWWGYRDPSEYRSLGPAEREFILRGGARDTDRGGLRQFRAAL
                     RSGRVWVVACGFACYGYTINIVLTWMPEFLQREFHVRLLQSGFYSMVPWAVATVAELAV
                     GGWLVDRLIRRGRDPWVVRRTVLTCGLALGGTIGAAGGAGSPALAVCWMSVSLAGLAIA
                     APVAWGLPGLLAPPGAVGAVSGLMNFLNTAATAGGVLLTGWLAQVSGSFDTPFLFAVGV
                     LAVGVTLYWRALRPASVRDTGPVRELHRV"
     misc_feature    complement(18885..18887)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19288..20286)
                     /locus_tag="TU31_RS23100"
                     /old_locus_tag="TPA0598_07_01130"
     CDS             complement(19288..20286)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088668.1"
                     /locus_tag="TU31_RS23100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01130"
                     /product="2-hydroxyacid dehydrogenase"
                     /protein_id="WP_042157878.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 7.2e-61, bitscore:
                     200.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHSDPQPVKNVLAVVSPHVGGRATGAALAGLFPGRARVTVVE
                     SADEDPAALRAAHLLITGLSPVTAGHLAAAPHLELVQCASHGFDYVDLDAARERGVPVC
                     NIGSSGAEKQNVAEQTFALMLALAKQLVPAHTALVEADWALPRLQQSLTELSGKTLGII
                     GLGHIGEEVARRAVAFDMTIVYTGPRPAGPETEARLGGARHMDLDTLLRTSDYVTLHAP
                     LTDRTHHLLDAERLALLKPTAFVINTARGALIDQDALADALEAGTLAGAGLDVFDPEPP
                     TAALRLLKAPNVVLSPHVAGVTRETLVRIALAAVQNVVGHLEGKPLRDVVS"
     gene            complement(20283..21452)
                     /locus_tag="TU31_RS23105"
                     /old_locus_tag="TPA0598_07_01140"
     CDS             complement(20283..21452)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389355.1"
                     /locus_tag="TU31_RS23105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01140"
                     /product="lactate 2-monooxygenase"
                     /protein_id="WP_042157880.1"
                     /transl_table=11
                     /translation="MAKHWADFQYEIYLQGMTGVVPRLPTDLTRLERLAEQRLGPGPVG
                     YVAGSAGTGSTAVANRAALDRRRIVPRMLRDVQERDLSVEVCGRALPAPLALAPVGVLS
                     IMHPDAESAAARAAAAQGLPYILSSASSTPMEQVAEAMGDGERWFQLYWAKDREVTRSF
                     LHRAKAAGYTALFVTLDTPLLAWRPRDLDQAYLPFLHGVGTANYFSDPAFRAGLAKSVH
                     EDPDAAVRHFVGMFADPAKTWPDLAFLRENWDGPIVLKGILHPDDALRAAEAGVDGVVV
                     SNHGGRQVAGSVAAADALPRVVEAAAGRLTVLFDSGIRTGDDIVKALALGAKSVLVGRP
                     YAYGLGLDGQAGVEHVLRCLLAEFDLTLALSGHASPATLTADDLIEESV"
     misc_feature    21424..21442
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.3"
                     /tool="antismash"
     gene            complement(21587..22048)
                     /locus_tag="TU31_RS23110"
                     /old_locus_tag="TPA0598_07_01150"
     CDS             complement(21587..22048)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601811.1"
                     /locus_tag="TU31_RS23110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01150"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_042157882.1"
                     /transl_table=11
                     /translation="MAKRKLTQAEMPVADHAFYGLVWAGTVLTERVDRALSKAHDLPVS
                     WFEVMLWLASSPDPVPASVLGNSTMLSRSQVSRVVDALQSRGLVTRTPSARDARSVEVS
                     LTPEGHQLFEAADATRRACLTPVFTDLLDQQDLEALSTVWRKLKANKEG"
     misc_feature    22030..22044
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            22143..22991
                     /locus_tag="TU31_RS23115"
                     /old_locus_tag="TPA0598_07_01160"
     CDS             22143..22991
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-180). E-value: 2.6e-16. Score:
                     52.0. Matches aSDomain:
                     nrpspksdomains_TU31_RS23115_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088674.1"
                     /locus_tag="TU31_RS23115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01160"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_042157884.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-34, bitscore:
                     114.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPSSKVVLITGTSSGIGLAAAVAAAQAGWRVVATLRDTGRSGA
                     LRKAAEEAGVELDVRQLDVTDERSVAAAVDGVIADHGRLDAVINNAGAGHLGTLENESV
                     AEVRAVMEVNFFGVLHVSKAALPHLRATGGRLITVTSVGGVIGQPFNEAYCAAKFAVEG
                     YMESLAPVAARLGVAVSVVEPGAVATEFVNNIGVDLAAEVAAAGPYADALQAYLDRTVA
                     QFLNGAQTPAEAAGAVLEALTADRPAFRLQTSDWAREFTGTKLTDLDGSAVLGLTGGWV
                     G"
     aSDomain        22164..22682
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS23115_PKS_KR.1"
                     /evalue="2.60E-16"
                     /label="TU31_RS23115_PKS_KR.1"
                     /locus_tag="TU31_RS23115"
                     /protein_end="180"
                     /protein_start="7"
                     /score="52.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGTSSGIGLAAAVAAAQAGWRVVATLRDTGRSGALRKAAEE
                     AGVELDVRQLDVTDERSVAAAVDGVIADHGRLDAVINNAGAGHLGTLENESVAEVRAVM
                     EVNFFGVLHVSKAALPHLRATGGRLITVTSVGGVIGQPFNEAYCAAKFAVEGYMESLAP
                     VAARLGVAVS"
     gene            complement(23119..24006)
                     /locus_tag="TU31_RS23120"
                     /old_locus_tag="TPA0598_07_01170"
     CDS             complement(23119..24006)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543160.1"
                     /locus_tag="TU31_RS23120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_07_01170"
                     /product="phenylalanine 4-monooxygenase"
                     /protein_id="WP_042157885.1"
                     /transl_table=11
                     /translation="MSTAWQYTPISADGRLGLANQHPGRSDPAYRRRRDALAARAEGHR
                     VGAPYPAVDYTEDEHRTWRAVHQALGPAHHAHACRAVLDAGEDAGIRADRIPQHTEVSA
                     ALTARTGFAFTLAGGVVPNERFLGAMEHGYFHAVQFVRHPAVPLYAPEPDVLHDVFGHG
                     VHLSCARLARLYRLIGQAANRTETAEALDILSRVYWFTLEYGLITEAGTPKALGAALLS
                     SYGEIGAHDGRTVRPLDLRAAAATPYRISGYQPVLYTARSLEHLEDVLGAFCADFDDES
                     ASRLGVPALSRDRA"
ORIGIN
        1 tggaaccagg ttcgggcagg acggcgaggg gagtggccgg ggccggctcg ggctcggggg
       61 cggtggactc gggctcgggg tccgccgggg gcgccgatgc ggcccggtcc ccggtcacct
      121 ccgctgccgg ggacggggcg ccggcgggct ggacggtcag cagcagcgcg gcaggcagcc
      181 agacggtgct ggtgacgccg ccgcccgggg tacggctcag ggtgacccgg atgcccgagc
      241 ggcgggcgag gctgccgacc acgaacaggc cgaggacctt ggtcggtacg aggtcgagcc
      301 gctcccggcg gatcagccgg gagttctcct cgtcgagccg ttccgcgctc atgccgaggc
      361 cgtggtcgat gatctcgatc agggcaccgc cgtccgcggt gatgtcggtg ccgggccgga
      421 cgaccacctc gacgggggtg gcggacgggg agaacgagac cgcgttctcc agaagttcgg
      481 cgagcagcag cgtgaggtcg tcgacgatgt cgggtccgac ggtgacctcg gtctcggacc
      541 gcagggacac ccgctggtag ccctcgatct ggccgagccc cgcccggatg acgttgacca
      601 gagtggtcgg ccgggcctcc acctcggtgt cccggattcc ggcgagcagc atcagactgt
      661 cggcgttgcg ctggaggcgt acggcgatgt ggtcgatgcg gtacatccgc tccaggacgt
      721 ccgggtcggt ctcctcgcgt tccacggcgt cgatcagcat cagctggcgt gaggtgaggt
      781 tgctgacccg gcgtccgacg ttgccgaaca tctcggcgac gttgcggcgg ctgagcacct
      841 gccgctccag cagcgccgcg gcggtgacct gcacctggtt gaacgcctcg gccaggtggc
      901 cgatctcgtc acggaccggg acggggatcg gccgcggccg cagcggggcg cgctccgtcg
      961 aatcgtcgtc ctcgaccctg gcgagttcct cgccggccac gtcgacgacc tgctcggcgg
     1021 cgccggtcag ggccgtcagg ggacgtacca ccgagcgtcg gaccagcacg gagaaggtga
     1081 gccaggaggt gaagccgagc agcgcgaggc cgagcatcgc cagtgcgttg cgcagggcgc
     1141 tcacggagag gctgtcggcc tcgtcggcga tctgctcgat cagcgaccgg gtgatgtcga
     1201 gacgggcccc ggcctgccgg gtgccggcgg ccatcgcctt gcgcagctgc tgcgggctct
     1261 ggccctgcag ggagccgggg tcgatctgga gctccgcgaa ctgggcctcg atgccgttct
     1321 cctcggcatc gcgctcgatc ccgcccaggc gcagcatctg gtccggggtg gcgatccggc
     1381 cgaagcgttc cgtctgttcg tcgaagagct tgtgggcgcc gaccgcgcgg gtgtactcgg
     1441 tgagcgcgtt ggcgtcccgg gtctgggcgg agaacacccc gctctcgaag gccgcatggg
     1501 cggcgtcggc gcgcagcacc gtgtcgagaa ggtgggtgac cgaggacgac gaggagccga
     1561 tgaagcggtc caggccgatg ccgtcgatca ggtagccgac cgcggcggcg tacgcggggt
     1621 cgatgccggc cgccgggacc gagccccgct cggccttgtc gcgcagcacc gcgaggcccc
     1681 ggatgtaggt gagggcccgc gcctcgtcct tgggcaggtc cggtccgaac gcggactgga
     1741 cggcggtgac ctgttcatcg gtcgcctgct gcgcccggcg gtaggcggcg gtggacggca
     1801 gggcggcacc gggccggacc gactcctgtt ccacggacag cagcagcgcc tgccggtgtt
     1861 cggcctggat gtcgttgatc agcctggcga cctgctcgct gtcccgcacc agctccgcgg
     1921 tccggtcggc gtccagggcc ttgtccgtct gcgtggtgac gccgatgccc agcagcacgc
     1981 cgacgaccgc gaccggggcg atcaccagca cattgagctt ccgccggaac ggccatcggt
     2041 ccaggagcgc gctcgtctgc ggacggaacc acggcctcat cggtgaacgc cgggaccggt
     2101 ccggttcgtg tgacgggtcc actgtgtcca cagacaccca ggcctcctta cgacgttctc
     2161 ctgagcggtg accgaggtgt tgttgttgcc gaccgccgac gacgggggac agcgacgctt
     2221 gcggatttcg ttccgaacgc gaacgaaaag attgcgccac atgcccgacc ggccgtgaac
     2281 actaccgctt gtgcacgggc atgcaacaca tgacgaccaa tggccaggtg gtattcaatt
     2341 ctttgtcatg tttggcccgt tgcctcctct gcggagcgca gtgccgttgg atgggccgat
     2401 tggccggatt tcgcgggaag cggggcgcgc ggagcggctc gttccgcacc ggggacttgt
     2461 ggcggacggg cgcgccgtac gttcccgaag gcggctgctg tgccgagcac cgccacccgt
     2521 aacctgtctc cccccacccg aacccgtatc ctcattccgc cctgcgagga gacccgtgca
     2581 ccccacccgc aaggcggccg tgaccgccgc cgcactcctg gtcatggcca cctccgccgg
     2641 ctgtgaaccc ggcgccggcg ccaccgcgtc ccaccgggac tccgccgccg agcccggatg
     2701 ccccaccgtc ctgtcgaagg ccaagcaggc ggtcaagaag gccgaagagg tcaacgcccc
     2761 ctggcggggc cccaccaccg ggcccaaggc cgtccacggc aagtccgtcg tctacatagc
     2821 ccagaccctg accaaccccg gcgtcgccgg cgtcgcccaa ggtgtccagg aagccgccaa
     2881 gatcgtcgga tggcacgccc gcaccctcaa cggccagggc acgccggacg gcctgcgggc
     2941 cgccttcaag caggcactcc gcctcaagcc ggatggcatc gtcatcagtg gttttgaccc
     3001 cgggatcgcc ccggcagagg tcaagaaggc gaattctgcg ggaattccgt tgatcggctg
     3061 gcacgccgcc ccggcccccg gccccagcaa ggacccgaag ctcttcagca acgtcacctc
     3121 ccgggtcgag gatgtcgcga agatcagcgc tgactggatc atcgcccggt ccaacgggcg
     3181 cgcgggcgtc gtcctgttca ccgacgcctc ggtgccgttc gcgaagcgca agtccgatct
     3241 gatcaagaag gaactcgcca cctgctccgg caccaagctg ctgagctaca ccaacatgcc
     3301 cattcccgag gtcaaccgcc ggtccatcaa ggaagtccgc tccctgctgt cccgtttcgg
     3361 ccgcaagtgg acctactccg ccgccatcaa cgacctgtac ttccagcatg ccgcgcccgc
     3421 gctgcgcgcc gcgggcaagg acggcgccgg cgccccgttc aacatcggtg ccggtgacgg
     3481 cgatccgtcg gcgttccagc gcgtcaacgg caagcagttc caggccgcca ccgtgcccga
     3541 gccgctctcc gaacagggct ggcagatcgt cgacgagttc aaccgcgcct tcaccggcgc
     3601 cccggacagc gggtacgtcg cccccgtcca catcgccacg gctaccaaca gcggcggcgc
     3661 actgtcctgg gactccgagg gctaccgcca ggcctaccgc aagatctggg gcgactgacc
     3721 ctccccggca ggcccgcggc ctcccggacc gcgcccatgt cccgtcggcg gatggtcact
     3781 tgggaatggt cgaggcgaca tcgtcgaggg tcgcctcggt gaccaggccg gtgtcctcca
     3841 gcacgtccat gtggtcctgg acggtgttgt tggtctgggt ggccagccgc cggatcagtg
     3901 tgttcttggt ggtggcgcgc acctcgccga tggtgatgaa gatcttgccg tgcgaagcgc
     3961 gcagcaggtc cacgaagagc tggtcgaacg ccttgccccg ggcgtccttc aactggtcca
     4021 cccagccctg ttgttcggcg ctggcctcgt cggggatggg cacgctcagc gcctcggagt
     4081 cctcacgggc cagctggtcg agtttgctgt gtccctccag caggtgcatt ccggcgcgct
     4141 tgatggcctc gctcgatgcg tgcgtctggg cgagccggcc cgccggcatc tcccacagcc
     4201 cggcttgccg gaccttggtg aggaaggtct tgtccagggc gctgaggggg cccgcattgc
     4261 cgccctgcgg cccggccggg gccgcgttcg cggcgggcag atgggccgag tgtgactcgt
     4321 cggcggagct gtttctctgc gcgagccaca cggatacgct cgcgacgacc gcgagaagag
     4381 cgaccgcggc ggctatcagg cggccacggc tcgcggtggg ctgggatttc cgtgcatgag
     4441 atttcatggt gcctcctgat tgcgcgcgag ggtcgccgga gcgctgtcgc ccatggggct
     4501 gttggggcac ggccacgcta acgtttgcat tgagcaaaga agtcgattca gcgacgatgc
     4561 gcaaaacccc ggggcggccg gtgacgatga gctagcatgc cgcccctcgt gcgcgcgggg
     4621 cccaggcccg ggcctcgcga cgtcgaagcc catgaaggaa cacagccggc gtgccgacgc
     4681 cgagagatgc cgggcggtag aaaggggaga tggcggagcg catggccccc acgaggggca
     4741 gggatgatgt ggatgcggtg acccaggcgg tactcacggc gtcgaggctg ctggtcgcgg
     4801 tgtccgcgcg gtcactcggc gaggtggagg agcgggtgac gctgccgcag ttgcggatgc
     4861 tggtggtgct ctccacacga ggtgccacca agctcgtgac cctcgccgag ctcctccagg
     4921 tcgccccgtc gaccgcgatg cgcatggtgg accggctcat cacggcgggg ctggcgctcc
     4981 gtcaggccaa ccccgacaac cggcgcgaga ccctgctccg gctcaccgac gaggggcggc
     5041 gcacggtcga ggaggtcacc gcccgtcgtc gcgccgagat cagcgccatc gtcgaacgcc
     5101 tcgcccccgc gcagcgggcc tcgctcatcg aggcactcac ggctttcaac gaagcggggg
     5161 gcgagccacc cgtggacgcg gcggaggcac acccgctggg atgaggtgct gtcacggtca
     5221 ggacggcagt tgtccctctg cgggacggca gtcgcggcgg ggccgctgtg gcgacaccga
     5281 ggacggcaac gggtggtccg tgcgggggtg ttgggagcgg cgcgcctgag gggcggtcgc
     5341 ggtgtgggca aagtgccgtc cgggcgcacc gccgggctct atgctcggac cacattcgct
     5401 cgcggaccgg aggctcgctg tgcagatcac gattcggtgt gaaggtgcgg actccgcagg
     5461 ggagttggcc gcgagcctcc accaatggct gctcgacgaa ccggatgccc gtcggcacgc
     5521 cgaggtgcgg ctggtcggtg ccgcgccggt cgagggtgaa ctgggattcg tgctcgatct
     5581 ggtgcagctg gtcgtcagct ccggcttcag cgcggggtcc ctgggctaca ccgtcgccca
     5641 gtggaagaag atgaacgccc cgcagctggc gatgagtttc gagcggaacg gccggaccgt
     5701 gacggtgagc ggcacggacg ccgaggagat cgcccgcgcc atccggcagc ttgacgaaga
     5761 gtgaagcatt ggcccgattg ccgcggttcg acgcttcgta tgccttgctg atcggggtgt
     5821 cggagtacca ggaccacgag tttcccgagg tgccggccgc gatccacaat ctggcggggc
     5881 tgcgcagtgt gctcgcaccg tccgacggcg gaggctttcc ccgcgagaag tgccgcatgg
     5941 tctccaaccc gcggacgggt gaggggatgc gggtcgccat caagcgggcg gccgagtccg
     6001 ccaccgacgt actgctgctc tactacgtcg gccatggctg gaaagtcgac ggcgacctct
     6061 atctggcctc ccagtcgtcg agtcctgatt cgatcgaaac cacggggctc gcgtacaaga
     6121 cggtccgccg gctggtccgg agctccccgg ccgcgatccg gatcatcgtc ctggactgct
     6181 gcttcagcgg ggtcgccacg ggactgctga gcggtacggg cgaccttcgc ctcagggagc
     6241 ccgaggtcga gatcctcctc gacgaggagc tgcccgacga ccatgccgac ggtgtttgcg
     6301 tcatcgcctc cagcggcccc aaccagccgt cccaggactc ggacggggcg gatcacacgg
     6361 ccttcacggg gcatttcctc gccaccctga aggccgccac acaggccggt gaagtgcgtg
     6421 atctggagac ggtgttcgac gggacaaagg cggcgatggt gtccgcggag ctgcggcatg
     6481 cgccgttgat cgcttcgatg ggaggggccc gccggctggc gctggtgaag agcctgacgg
     6541 ccgtcgatcc cgtgcccgtt cccgttcccg tcgtggtgcc ggaggccgcg gtcgtccgcc
     6601 ctccgacggc ggcggacgag gccgtggccg cggcggcggt cgcgccgggc gacgggccgg
     6661 ccaaactcat gagctggcac accccggtgg gcagcgcgga catcttcgat tccgcgctgg
     6721 cactgacgct gctgcaacaa gccatggcaa tggggggtga cgatgagcac gccggatagg
     6781 aagcggagcg gggagctcga ccggctccgc gtccaggcgg aggaagactt ccggacctat
     6841 ggcccacagc ttgcggaccg gctcctgacc gcttgtcagc ggcttcgggc caccggtgaa
     6901 ggagaggaag ccctcctcat cgcgcaggaa gcggtgggga ttcaccggga actcctcgac
     6961 cgctaccact gcgtcggcac cgggctggcg cacgcgctgc ttcagctggg gctctgcctg
     7021 gccgagctcg gggcggccga ggaggcggtc gatgtgctcc aggagtgcat cgcgctcagc
     7081 gacgtcctgc cggcacctct gcggccgccc gcgctgcggc tgcgctgcaa cgcgctcgaa
     7141 tgcctcgcgc tgatcctcgg ttcgtcggac cgcacggcgg aggccgtcgc cgcctcgcac
     7201 ctggccatca ccggctaccg ggagctgtac gaggaagacc cgagcgtcgc gccggagctg
     7261 gctcgtggtc tgcacaacct cgccaccctg ctggcctccg gcgccgagtg ggagcaggcc
     7321 ctggtccccc tggaagagtc cctcgcgatg tatgagcagc tctccgcagg gggcaagacg
     7381 gcgctggcgg cggagcggag ccgggcccag cagttgcacg ccgtattggc gggaggagag
     7441 ggggacgccg gggaggtcgc gggcgaagcg ctgtccgcct atcacctggc ggcggaggcc
     7501 gatgcgtact cggccacctc gggactggcc ggcatcccgg cgcatgtaga gatcagtcgt
     7561 gttgaacccg ccgaccacgt cgcacagcca cacagagagc agcggagcat ggacttgaac
     7621 cggattgacc tcaccgaagc ggtgcaggcc gtacgcgatg atctgcgtgc ggccaccgaa
     7681 tcgttcgacg gcggtgacct ccagttcgac atgggaccga tcgagctgga attcaccgtc
     7741 gagctggagc gcgacccccg ggcacgatcg ggtgtccgca cctgggtggt gacggacgcc
     7801 ggcacgggga gggtgtcggc ccccgccagg caccggctca cgctcaccct gacaccgcga
     7861 caggtcgcct accggagcgt cgatgtcgcg aacaggatgt aaaaggaggc cgatccgggc
     7921 caacttcggc cgctcggcga ctccttggag ccctgccgca cggccgctgc ggtgggtcga
     7981 cgcccgtacc ccggacgcgt actctcccca ggatgcgcct caccaagtac acccactcct
     8041 gtgtccggtt ggagcgtccg ggcggcgggg cactggtcat cgaccccggt gtctggagcg
     8101 aggcgcgggc gctgcacggt gccgacgcga tcctggtgac gcacgaacat gccgaccatg
     8161 tcgatgtgct gcggctcaag gggatcggcg caccggtcta cgcacccagg ggcgcggact
     8221 tcggcggcct cctggacgtc atcgaggtgg agccggacga ggagttcagc gcggcgggct
     8281 tccacatcac ggcgcacggc ggccggcatg cccggatcta cggtgacctc cccgactgcg
     8341 ccaacctcgg ctatctgatc gacgagcgcc tctaccaccc cggcgactcg ctccatgtgc
     8401 ccgaaaagcc ggtggagacg ctgttcgtgc ccgtgcaggc gtcgtggctg cgtacgtccg
     8461 aggccatcga cttcgtccgg gcggtcaagc cggagcgggc ctacggcatc catgacgcgc
     8521 agatcaacga acgggggctg cacagcgtca acggctggct cgacgaggag gcgggcgggt
     8581 gttaccgctg ggtgccgccg ggcgcctcgt taccttgctc ggagcggtga gcgcccgctc
     8641 gggacgccgc gagccccgcc cgccgggccc ggctccgggc gggtgacggg cggacgacgg
     8701 gactgtgcgg acccgcctga gggcaggacg cccgcgagat gcccggtgac tgatgtccgc
     8761 cgactgatat gccgtgcccc tgaccgggca ggcatgcgga tatgaccgtc ctcgtcggaa
     8821 cctccggctg gcagtacaag gactggcgcg aggtcctcta cccgcgggag cggccgcagc
     8881 gactgtggct ggaggagtac gcccggcact tcgccaccgt cgagagcaac gccgccttct
     8941 accggctgcc ggaggagaag accttcgcgg actggcggga ccggaccccc gacgggttcg
     9001 tgatggccgt gaaggcaagc cgctatctga cccacatcaa gcggctgcgc gagccgcagg
     9061 aaccggtcgg gcggctgatg tcgcgggccg ccgccctcgg cccccggctc gggcccgtgc
     9121 tgctccagtt gccgcccaca ctgaaggcgg acgccggcct gctggacgac tgtctcagct
     9181 gctttcctgc cggtacccgg gtcgccgtcg agccccgcca cccgtcgtgg tggaccgcgg
     9241 aggtccgtac ggtgctggag cggcggggtg ccgcgctgtg ctgggcggac cgcggttccc
     9301 ggcccgtgac gcccctgtgg cggaccaccg actgggggta tctgcgcttc cacgagggcc
     9361 gcgcggaacc ctggccgcgc tacggcaggc aggcgctcac cacctgggca cggcggatcg
     9421 ccgacacctg gccggaccgg gccgacgtct acacctactt caacaacgat ccgggcgggg
     9481 cggccgtccg cgacgccacc accttcgccc gtgccgtcac ggcccgcggt cgcaccgtga
     9541 gccgtgcgcc gtccgggcgt ggcgccgccc ggtgaccgtg gggccgggat atatctgcgc
     9601 tcggacggcc gggccgggcg aacgaggtga cgaggtgaga cacggatgat ccgcagacgg
     9661 gtggtggtct ccggagatgt gcacggcgtg ttcttccgcg acagctgccg gcgcacggct
     9721 gacgggctgg gggtggccgg ctgggtgcgc aacctcccgg acgggacggt ggaggccgtg
     9781 tgcgagggcg agcccgagcg cgtgcggcgg ctcgtggact gggcgcacga gggtccgccc
     9841 ctggccaccg tcgacgcggt ctccgtacgg gaagaggaac cggaggggct gacgggcttc
     9901 gagatccggc cgacacccgc aggattctga ccggccgggg cacccgggcc cgcttgtcac
     9961 gggccgacgc cccagcccct ccgcacgacg ggcggccggg tcaccccatc aggaacgccg
    10021 cgtcccagcc gttcacctca gctacgacga ctccacggcg ggcgtcggcg tactcggcca
    10081 ggacgagtgc gatcccggcg gcgccgtcca gcagcccggg gtggtgcacc cggtacggtg
    10141 cggaccccga cgcgggggag ggcggcacca cctggcggta gccgaagggg gttcggggat
    10201 cgcactccgc cacgagctcc cgggccagac cgtccgccct cgcccaccac tccgtgcgtc
    10261 ctgtggcgac ggccatccgg ctgacggtgt gcaggacgcc cgcccggcca tgacagaagc
    10321 ccgggtcggt ggacaccgcg gcatcgagcg ggcggcgcac caggccactg accgcgtcct
    10381 ccgccaaggc cgtcagccgg cggtcaccga gtgcccgccc ggccagatac agcgaccagg
    10441 cgatcccggc tgtcccgtaa caccaccccg gccggctcct cgcccccacc tcccggggcg
    10501 gtcggcgctc ctgggacggg tgggcaggct ctccggcgtc ctccgcaggg gcgacgcgac
    10561 cgggccaccg catgcccagg tcgtcggtgt gccccacgct gaccacccag tcggccatac
    10621 ggcggagggc gtccgccatc cccggcaccc ggtgtccgga ccggtgagcc agcgacatca
    10681 gggccagggg cccgcaaatc ccgtgcgcga caccgacgtt gaagtcaccc ctcgggtact
    10741 cctcgcggtc acgggggagg agatagcggt cgggggcgca ccaccacccc ggcacgtggc
    10801 ttccgtcggc cgccgggggc cgcaccggat gcgtcatctg gaccaggtag gcgaggacgt
    10861 cgtggagtac ctgcgcgcac cgctcgtcgc cgtggtcggc cgccagcagg aggccgcggc
    10921 cctcgcccgc caggcccgag atcacgtcgt agtcgtcggc cgccagcccc ggaccgtctg
    10981 cctgccgccg ggcctccaac cgggcgacat gggcctggac atatgcggcg tgcacctcgg
    11041 cgcagcgcgc cagcagccgg gtgtagccgc cgtgcgcgtc ggcgtgcagc cgtgccggca
    11101 gcagcagatc gccgaccgtg gccggaccgg cgccggtggt tgccgcgacg gccgccgcga
    11161 gatgggcgtg cccgatcgcc gcgtaccggg cgtcgttccg ggcgcacctg gtgtgcagca
    11221 gtgcgatgcc cgggtgcccc atcagcagcg acgcgggctg ccaggcgggc tgcgacagtt
    11281 ccggcggcag cgcggcgagc gcctggtgcg ccgtacgggc cacctgctcc ggcgagctca
    11341 gcagatcggc gacgcggtac gcgaggtccg acgcggcatc gcacagcgcg tggggtgcgg
    11401 tcatcggttg ttccgccgcc gtccgagcca cagcgccagc gcctcacggg ccgtcacctg
    11461 cgccgtccgc tccagctcgg gacgggggcc gagcagccgg ttgcagtgca tatgggccag
    11521 gctcagcgcg atccgtgccg tccggtcgcg gtccgtcgca ccggcggaca gcacctcgcg
    11581 cagaccggcc agcgccgggc cgcgggtgct ccaccccacg ccccagccgt ccgccgcggc
    11641 cggcggcccg ggccgggcgt gcgcgtccag cagcgcggcg acctgctgct tccgggaccg
    11701 cgggacctct ccccggcgct ccagcaccga cgggccgctg agccagtcga gcgcctcgtc
    11761 cggggtcccg aggcgggtga ggatgtcgag gatgcccagc gcggccggca gcgtgggatc
    11821 gcccaactgg tcgggggcca tggccagcag cgtgacgacg gactcgctgt cggcgtggaa
    11881 gacgcgctcg gcgtgcccga gggcggccgg tccgccgtac cgctcgactt cgggctcgta
    11941 ggtgtccagg cccaccgtcc cgaggagccc cgccgccgcc cgctcccgcg cccaggagtg
    12001 cagcgcgggc agcagcaccg gccacagcga ctctggcgtg ccgtggaagc gcagccggat
    12061 gtgcggtgcc gggtcctcgt aacggaggaa gaaccagtgg tcggcgcccg cgctgcgcag
    12121 cagttcgggg tcggtgagcg cgccgagatg acgggccagc acctccggct ggcgggccgg
    12181 gggcacatag agcttcgcgt agagccactc gccgccgggc agatgggtgc gcgcgccacg
    12241 gccgccgtcc gggccgtcca acaggagcgg gaccggcgcc gtggcagggc gggcctgccg
    12301 ggtaccgggc gcggctcccc ggccgtcggg ccgggcaaag acgggaaaga cgaactcggc
    12361 ggcatggggg ccctcagcgc tccggaacca ctgccgctcc gcccggcctc cgcactgctc
    12421 caccagcgtc agaccggccg cccgccgcac ctcgtcccgc aagaccggga gatgcagcgg
    12481 gtcgtcgagg tcgaccgcga cgcggtgatc gcccctggcg agcagcaccc gccgaggcac
    12541 atcccagcgc cgccgccacc gcccgacctg ctctccccac tcctcatccc cttggtcggc
    12601 tgccgcgcgc agggcccggt ccggcagcca gcgcgccggg gagagcacgg tccggccgtg
    12661 gcgcacccgc ggcagcgcgg gagccgaggc ccagcgtccc cagctccacg gtgcgcagaa
    12721 ggaccggccc tcctgcccga gctccagcag gaaccgtgcc acgtacggaa gatggccgtt
    12781 ggccgggttg agcatcgagt acgagagcgg gcgcaccctg cggccggtcg tgccgtcgac
    12841 gagccggagg ccgtccctgt ccgcgtggac cgcgaggttc tccaggcgca gatcgtgcgc
    12901 cgtctccgcc gcggcggggc cggcacccag ggggatgcga tgggagagcc actgcggaac
    12961 ggcggagaca ttggcggaac gcgccaccct gggccggtag gcgagacagg ccgggatctc
    13021 gtcgtccggt gcgctccgct ccgcgtgcag cgccaggtcc tgaatcagag tgcccgaggg
    13081 gccgaatagc ggcgcgaatc ggctgaacat cgcccccgcc agcggcgaca ccgcctgcgg
    13141 cgcgagcacc agacggaagt ccccggcgca cagggcctcc cagtccggtg ccaccagctc
    13201 ggcgcccacc tccatgctca gcggggccgg cccgcgctcc gccggttcca gggcgcgcac
    13261 ggtctcctcg tccagcacca cttcccgtac gccactccgc gccgcgtcca tcagcagctc
    13321 gccgaggacc cggtcgcgct ccccggactc gggggagggc acggccccgg gctggcggta
    13381 ggcgcggggc agccccaacc cgcgggcttc gtcgagcagt tccaggaccg gcaccgcacg
    13441 gtcggtgccg tacttttcga ggaaggccag gtggtagtcg cgcagatgcg gagtgccgcg
    13501 gtgcacgggg gaggtccgcc acagcaccgt cgcggcctgt gccgcttccc gggccacctc
    13561 ggacggcagg gtcagccgta ggtccaggga caggtcggtc tggaggacat cgggagcagg
    13621 atccagcgcc cgcatccgtg cggagaccgc ggtcagccgg gcccgccggc tgcccggaga
    13681 cgtggcgtcg agggtgctca actccgcctg aattgcgcac agttcgcgag ccgtggggtg
    13741 gtcgacaccg tgcaaccggt cgcgtacgtg gtcgaggggg gcggtgcagt cgggcggcgg
    13801 cgtcaggtcg gtcagcagga agtggccgcg tacgagctgg gtgatgctgc cctcgaccgc
    13861 gccttcgggc gcatgcggga agacgcgccg gccctcttcc accagccggg gaaacggcgt
    13921 ggtccgcgcc gcggccgcca gcaggacctg gaccacccgg gtgtggcgca ctgaacccgc
    13981 caactgccgc tcaccagtgg ggtcgtggtg gtcgacgagc accagccggc cgtcccgtac
    14041 ggtgtgcagg ttgttggccg tgagtcgcga gcgctccagt acggcgggga catcgcgcag
    14101 cgtctccagt acgccgtcca gccaggccgc gtccggccgg gtcacggtgc gtccggcccc
    14161 gagcggttcc cgggcgggtg ccggtccgaa tccggcgaga ccgaccccgg cgaacaagcc
    14221 gaacggggtg gggcgatggg acatccgtga gcggtatttc gtcagcgaca gcgcgatgcg
    14281 gcgcagtgac ttgagtcgga gcggttcccc ggcgacggcg cggtccacct cctccgcgag
    14341 gctcgcgctg gccaggctca gggccgtcat gagccgtggt tcggcggcga gttccgctat
    14401 ccgacggtgc agccgggctt cttcgtccgt gacttcaccg gacggcaggg acgcggaggc
    14461 cggggggtcg tccgagggca gtgggagggc cgcggcccgt accagagcca ccttcccgca
    14521 ctcgaatctc acatcacccg taccactcac gcctgtcccc gccctgttcc ctgacaccgc
    14581 ttgacccgac gacggtgtgg gtgccgcggg agcgatgtcc cgcggcaccc acaccggtgt
    14641 gtcagccgca gtgccaggtg gtgggccggc agacctgcgt catgagcttc gagtcctgcg
    14701 ccttcacggc ggtcgtggcc gactccatga tctccatgtc caggtcgagg tcgaattcgt
    14761 ccaggttgat ggtgacgttc tccatggtcc cctccaaaga aagataattt aattccggag
    14821 taatcccggt tgttgcggaa atacttcgca accgccgggg tatttcatcc gaggccgcga
    14881 tcttcgtcaa gagcgtttag aacccgcgat agggggcaat tcccctgctc cgggccggtg
    14941 ttcacggtgt cgtctgcctc cgcgacgccc ctcggtcccc gtcagaggaa gtcgagttcg
    15001 gaggtgagcc ggacccccgt gcggcgcagc acttcctgtt gtacgagctc gatcgcccgg
    15061 gtgaaaccgg cggcggtcgc cccctcgtcg gcgacgagtg tgtaatgcag cgaggaaatg
    15121 cggacgcccg tgacgatcgg ggtgctcagt tcgaaaccgg cctgccggat gagccagctc
    15181 gcactcaccc gcgtcgagcc gtcggggaag tggttcaccg gggcgttgcg tgcccgcagg
    15241 ccgtcggcct gggcgggggt gatctcgggg ctgaggaaca cactgccgac cgatctgtcg
    15301 tcggtgccac tacagcccag caccatgccc ttgctccgcc ggaccgcgag caccgcctgg
    15361 gtcacctcgt tcaggggcac ccggctcccg agcgggacat cgagtgcggc ggccaccgtc
    15421 cgatacgtca ccggcgcgct cagctcggac gggcgcagcg cgaagaccag attcagcagg
    15481 gtccaccggc gggagtgttt gaagacactg gtgcggtggc ccagcccgca ggccgcggcg
    15541 tccagtgtga ccatgcggcc caactcccag tcccacgcgg tcacttccac caggcagtcg
    15601 gcggtctcct gaccgtaggc gccgacgttc tggaccgggg tggcgccggt ggtcccgggg
    15661 atccccacca gcatctccat gcccgtgagg ccctcggcga cggtggtgtc gaccaggtca
    15721 ccgagcaggt gtccggcctg cacctcgacc agcacccgcc cctcgtcggt acggccggtc
    15781 atccggacgc ccttggtact catccgcagc accgcgccct cacagccggc gtcgctgacc
    15841 accacattgc ttccttcgcc gagacagacc ggccggccgg gggaagcgtc ggccagcgcg
    15901 acgaactcgg ggaagtccgc ggggtcgaac agctcgaaga ggaccgccgc cggtcctccg
    15961 agccccagcg tcgtcatcgg ggcaagcggt acctcgtgcg tgactcgcat atgttcctgt
    16021 ttctcctgga tgccgttccg tgtcgagggg tcgtgccgtg ggagggggcg cgggggtgag
    16081 gaccggccct cagtgggtga cgagcaggac gccgtcccgc gccgtcgcac gacgagcggg
    16141 ggccggggcc ctgctgacgg tcccggaacg gcacggcagc cgacgggagc tcgtggccat
    16201 tctcagcaca ccgcccgcgc ccggcccgcc gccagcagat cgtcggcccg ttgcacgatg
    16261 tcgcgcgcca ccgcactgtc gtaccgcacg aaccgcctcc gcagcgccat cagccgcgcg
    16321 tgggcgcgct gcgagctgac gtgctcggcc agggccagcg cgtcggtggc ggccgccacc
    16381 gcgccgtcga gctcgcagcg cgccagtcgc gcctcggcca gcgaggcact gtgcagcagc
    16441 agattgcggg gctggctgcc ctggagcatg tcgatcccgc gcgtgagata cgactccgcc
    16501 cgcttggggc gccccaactc cagccaggcc cggccggcat cggccaccat gaccgcgggg
    16561 gtgagccagt acgcccagag cggctcggcc gagggccggc ccgcccggct gagctcggcc
    16621 gcgtcgtcca gggcccgttg acaggccgcc tcgtcgccga gactggcatg ggcccgtgcc
    16681 tcgcgggtgg ccagcagcgc gtggccgatg cccatgtcct cctgtgccga ccccttgcgg
    16741 gcgatacgga tcagccgcag cgcctcctcc gcccggccgg cccatccggc ccggtagctc
    16801 atacaggaga tgatgtacgc ggcgagcggc cggtcaccgg cggcccgtgc ggcgcccagg
    16861 gcggccagga agcgggagtt gctcagctcg tcctggccct ggtccgccgt cagccaggcg
    16921 gtgagctggc cgagttcggc gatgatgcgg tgcagttgcc gtccggtcga cgcgtcgtag
    16981 gagtacttgg cggccagcct ttccgcccac tggaggtcct ggagcgccca gtccagcacg
    17041 agcccgctgc tgccgctgtc gtccagctgg cgcagctgct ggattctggc ggtcagcatc
    17101 tcgatcgcga ccccgggaat ctcctcgccg cgcagccgcg acgggggcgg cagcgcatcg
    17161 tcgtccacca gccagtccac cgacgcggtg agcggatcga gggcggcagg ccgctgcacg
    17221 ggcgcggcgg ggcgcggctg agcggcgctc cgccgttgcg gcgggaccgc ggaggcgaag
    17281 tgcccgggcc acagcgcctc gaccgtgatc ggctcaccga ggtggtcgga caggatcgtc
    17341 gcgatgatgt acggcagccg gcgccggggg caggcgccct tcagccagtt gtacggagct
    17401 ttgctgctga tggtgccgtt gccgcaccgc cggttgatct cacgggccag ccgctccggt
    17461 ggccaggaca agcgggccag gcaggtcgct aatacagagg tgtcgttcat cggcggagca
    17521 cctcggccgc ggtggcgctc gatgccgcgg gaggggtggc cgggaccgtc ggctccggcg
    17581 accgccgggg gtgttccgga gtcaggccgg accggaccgg aatcgggccg acgatgtgca
    17641 tagccgcttt ccacgccccc ctgccgacaa ttgcccagcc atagtaggga ttccctgggg
    17701 tgggaggccg aatctgtgat gaccgacaca gctactgcac acagtatgca agtacaggat
    17761 taaagcatga ggtgcccacc cgggcctcag acccggtgca gctcccggac cgggcccgtg
    17821 tcccgtaccg atgccgggcg cagcgccctc cagtagagcg tgaccccgac cgccagcacg
    17881 ccgaccgcga acaggaaggg cgtgtcgaac gacccgctca cctgcgccag ccagccggtg
    17941 agcagcacac cgcccgcggt ggccgccgta ttgagaaagt tcatcagccc gctgaccgca
    18001 ccgaccgcgc ccggcggtgc gagcagtccg ggcagccccc aggcgaccgg cgcggcgatg
    18061 gccagccccg ccagggagac ggacatccag cagaccgcga gggcgggtga tccggcgccg
    18121 cccgcggcgc cgatcgtgcc accgagcgcg agcccgcagg tcagcacggt tctgcggacc
    18181 acccacgggt cgcggccccg gcggatcagc cggtccacca gccagccgcc cacggcgagt
    18241 tcggccaccg tcgccaccgc ccacggaacc atcgaataga agccggactg caacagccgc
    18301 acatggaact cccgctgaag gaactccggc atccaggtca gcacgatatt gatggtgtag
    18361 ccgtagcagg cgaaaccgca ggcgacgacc cagaccctgc cggaacgcag ggccgcgcgg
    18421 aactgccgca gcccgccccg gtcggtgtcc cgcgccccgc cccggaggat gaactcccgc
    18481 tcggccggcc ccagggagcg gtactcggac gggtcccggt agccccacca ccacacggcg
    18541 gtgaacagca cactgaccgc ggcgctgaac aggaacccgg cccgccagcc ccactcgctc
    18601 atcacgaacg ccagcaccgg gaaagccacc atgttggcca gcttggtggc cccgtcgaac
    18661 agggccgtcg ccatcccgcg ctcactgacc gggaaccacg ccgcggtcgc cttggaggcg
    18721 ccgaccatcg acggaccctc ggccaccccg agcagcagcc gcgccaggat gatcggcccg
    18781 accccgccgg ccaccgcggt cagcaggccc gcgacggccc acagcgcgga cgcgatccgg
    18841 gtgagccgcg agacccccag gaggtccacg agcatgccgg cgggtaactg caccaggcag
    18901 tacgaccacg tgaacgccga gagcaccacc ccgagttgct gaaggtccag cccgaactcg
    18961 tcggcgatcg aggagctagc caccgatatc gccgtacggt caaggaagtt gacgacgata
    19021 ccgccggcga gcagtccgcc gatcgcccaa cgggtacgtc cacggggttc cacgagcgtg
    19081 cgccagcctt tcctggtggg gcctcggagc cgatgccggg cggacgctac tccagtcgcc
    19141 ggggcggcag ccgtcgggcg tgtcgagaaa tggcggtggc acgccaggaa cgcgccaccg
    19201 caccgcccgc tcaggtgtgc gagcccgctg accggcaccc cgaacaatgg ctgaaattca
    19261 ggacggagcg cacccggcgc cccgccgtca cgacacgacg tcccgcagcg gcttgccctc
    19321 cagatggccg acgacgttct gcaccgcggc cagggcgatg cggaccaggg tctcccgggt
    19381 gacgcccgcg acgtgcgggg agagcaccac attcggggcc ttgagcaggc gcagcgccgc
    19441 cgtgggcggt tccgggtcga agacgtcgag cccggccccg gcgagggtgc ccgcctccag
    19501 ggcgtcggcg agggcgtcct ggtcgatgag ggcgccgcgt gcggtgttga tgacgaaggc
    19561 ggtgggcttg agcagggcga ggcgttcggc gtcgaggagg tggtgggtcc ggtcggtgag
    19621 cggggcgtgc agggtgacgt agtcggaggt gcggagcagt gtgtcgaggt ccatgtgacg
    19681 ggcgccgccg agccgggcct cggtctccgg tccggcaggc cgcggtcccg tgtagacgat
    19741 ggtcatgtcg aacgcgacgg cgcggcgggc cacttcctcg ccgatgtggc cgaggccgat
    19801 gatgccgagg gtcttgccgg agagttcggt cagtgactgc tgaaggcgcg gcagcgccca
    19861 gtcggcctcg accagggccg tgtgggccgg gaccagctgc ttggcgaggg cgagcatcag
    19921 ggcgaaggtc tgctccgcca cattctgctt ctccgcgccg ctggagccga tgttgcagac
    19981 cgggacgccc cgctcgcggg ccgcgtccag gtcgacgtag tcgaagccgt ggctggcgca
    20041 ctggacgagc tccagatgcg gtgcggcggc gagatggccc gcggtgaccg gactcagccc
    20101 ggtgatcagc aggtgtgctg cgcgcagcgc cgccggatcc tcgtcggccg actcgacgac
    20161 ggtgacccgg gcccggccgg ggaacaggcc ggccagcgcg gccccggtgg cccggccgcc
    20221 gacatgcggc gagacgacgg cgagaacgtt cttcacgggc tgcgggtccg agtgcggcgc
    20281 ggtcatacgg attcctcgat gaggtcgtcg gcggtcaggg tggcggggct ggcgtgcccg
    20341 gacagtgcga gggtgagatc gaactcggcg agcagacagc gcaggacgtg ctccacgccc
    20401 gcctggccgt cgaggccgag accgtaggcg taaggccgcc ccaccagcac cgacttcgcg
    20461 cccagggcga gcgccttgac gatgtcgtcg ccggtgcgga taccgctgtc gaagaggacg
    20521 gtgagccgcc cggcggccgc ctcgacgacc cggggcagcg cgtcggcggc ggcgacggag
    20581 cccgccacct ggcggccgcc gtggttggag acgaccactc cgtccacccc ggcctcggcg
    20641 gcccgcagcg cgtcatccgg gtgcaggatg cccttcagca cgatcgggcc gtcccagttc
    20701 tcccgcagga acgccaggtc cggccaggtt ttggcggggt cggcgaacat ccccacgaag
    20761 tgccggaccg ccgcgtcggg gtcctcgtgg accgacttgg cgagccccgc ccggaacgcg
    20821 gggtcgctga agtagttggc ggtgcccacg ccgtgcagga acggcagata cgcctggtcg
    20881 agatcgcgcg gccgccacgc gaggagcggg gtgtcgagcg tgacgaacag tgcggtgtag
    20941 ccggccgcct tcgcccggtg cagaaagctc ctggtgacct cgcggtcctt cgcccagtac
    21001 agctggaacc accgctcccc gtcacccatc gcctcggcga cctgctccat gggcgtgctg
    21061 gaggcggagg agaggatgta cggcaggccc tgcgccgcgg cggcccgcgc ggcggcggac
    21121 tccgcgtccg ggtgcatgat cgacagcacc ccgaccggcg cgagcgcgag cggcgcgggc
    21181 agcgcgcggc cgcacacctc cacggacaga tcacgttcct gcacatcgcg gagcatccgc
    21241 gggacgatcc gccggcggtc cagtgcggcc cggttggcga cggcggtgct gccggtgccc
    21301 gcgctgcccg ccacataacc gaccgggccg ggtccgagcc gctgctcggc gagccgctcc
    21361 agccgggtca gatcggtcgg cagccgcggg acgacgcccg tcatgccctg aaggtagatc
    21421 tcgtactgga agtccgccca gtgcttcgcc atccgtacgt cccgcctctc gtcgccgatc
    21481 gttgcgtgct ccccggagat cctggcgaca gtgacaggtc ccgtccaccg cgcagcgcac
    21541 aacacgcggg accgggaact gccggccggc ccacgaattc cccgtatcag ccctccttgt
    21601 tggccttgag cttccgccac accgtgctca gtgcttcgag gtcctgctgg tcgaggaggt
    21661 cggtgaagac cggggtcagg caggcgcgcc gggtggcgtc ggccgcctcg aagagctggt
    21721 ggccttcggg ggtgagggag acctcgacgg agcgggcgtc gcgggccgac ggggtgcggg
    21781 tgaccaggcc gcggctctgg agggcgtcga cgacgcggga gacctggctg cggctgagca
    21841 tggtgctgtt gccgagcacc gaggccggga ccggatccgg gctggaggcg agccagagca
    21901 tcacctcgaa ccaggagacc ggcaggtcat gagccttgct cagggcgcgg tccacgcgtt
    21961 cggtgagcac ggttccggcc cagaccagcc cgtagaaggc gtgatcggcc acgggcatct
    22021 cggcctgggt gagcttcctt ttcgccatgc ggccaggcta ccggttgcgt gtgtgcacac
    22081 ataatgctta aggtgtgtgt acacgcacct aatcaagcct cgtacggccc gaaaggttcc
    22141 ccatgtcttc cccctcgtcc aaggttgttc tgatcaccgg cacgtcctcc ggcatcgggc
    22201 tggccgccgc ggtggccgcg gcgcaggccg gctggcgggt ggtggcgacg ctgcgcgaca
    22261 ccggccgctc cggtgcgctg cgcaaggcgg ccgaggaagc gggcgtggag ctcgatgtcc
    22321 ggcagctgga cgtcaccgac gagcgctccg tcgccgccgc ggtcgacggg gtgatcgccg
    22381 atcacggccg cctcgacgcc gtgatcaaca acgcgggtgc cgggcacctc ggcaccctcg
    22441 aaaacgagag cgtcgccgag gtgcgcgccg tgatggaggt gaacttcttc ggcgtgctcc
    22501 atgtctcgaa ggcggcactg ccgcacctgc gggccaccgg cggccgtctg atcaccgtca
    22561 ccagcgtcgg cggggtcatc ggacagccct tcaacgaggc gtactgcgcg gccaagttcg
    22621 ccgtcgaggg ctacatggag agcctggcgc cggtggcggc ccggctcggt gtggccgtgt
    22681 ccgtggtcga gcccggggcc gtggcgaccg agttcgtgaa caacatcggg gtcgacctgg
    22741 cggccgaggt cgccgccgcg ggcccgtacg cggacgcgtt gcaggcgtac cttgaccgca
    22801 ccgtcgcgca gttcctcaac ggcgcgcaga ctcccgccga ggccgccggg gccgtgctgg
    22861 aggcgctcac cgcggaccgg cccgcgttcc gcctccagac gtcggactgg gcgcgggagt
    22921 tcaccggcac caagctcacc gacctggacg gctcggcggt gctcggcctc acgggtggct
    22981 gggtcggctg atccggcagg cgggacccgc gtgcacgcca ggtgccgggc gggggcgggg
    23041 gcgtgcgtct gacgtatgcg gcatccggcc cggccgggcc gctcatgcgc ggtggcgacg
    23101 gccggtggta cccggtggct acgcccggtc gcgggagagc gccgggacgc ccagccggct
    23161 cgcgctctcg tcgtcgaagt ccgcgcagaa ggcgccgagg acgtcttcga gatgttccag
    23221 ggagcgggcg gtgtagagga cgggctggta gccggagatg cggtacgggg tcgcggccgc
    23281 ggcgcgcagg tccagggggc ggaccgtccg cccgtcgtga gcgccgatct cgccgtagga
    23341 cgacaggagg gcggcgccga gggccttggg ggtgcccgcc tcggtgatca gcccgtattc
    23401 gagggtgaac cagtagaccc ggctgaggat gtcgagggcc tcagcggttt cggtccggtt
    23461 ggcggcctgg ccgatgagcc ggtacagccg ggcgaggcgc gcgcacgaca gatggacgcc
    23521 atgcccgaag acgtcgtgca gcacgtccgg ttcgggcgcg tacagcggaa cggcggggtg
    23581 gcggacgaac tgcacggcat ggaagtagcc gtgctccatc gcccccagga accgctcatt
    23641 gggcaccacc ccgccggcca gtgtgaaggc gaatccggtg cgggcggtga gggcggcgct
    23701 gacctccgtg tgctggggga tccggtcggc gcggatgccc gcgtcctcac ccgcgtccag
    23761 aaccgcacgg caggcgtggg cgtggtgtgc cgggccgagc gcctggtgaa ccgcccgcca
    23821 ggtgcggtgc tcgtcctcgg tgtagtcgac ggccgggtag ggcgccccca cccgatggcc
    23881 ttcggcccgt gcggccagcg catcacgacg gcgccggtag gccgggtcgc tgcggccggg
    23941 gtgctggttc gcgagcccca gccggccgtc ggcggagatg ggggtgtact gccacgccgt
    24001 gctcatgtcc gtcaccttgc tctgccccca ggtgcatccg gcgccgtccg ccgcccaccg
    24061 gcgtctgcgg ggatcggcgg tcgccctcac tttcctcagg atctcatcga acgggccgga
    24121 tggccgggtg gcgggcggcc ggcgaggggc agggggtggg ccgctcgata accgtcgccg
    24181 ctggcgcttg cgctcgcccg cgaaggggta atccatcgca gaaatcagcc tgacggggtt
    24241 cccggggaat tccctttatt gccgctgtat ttgatggtgg cgcgggagcg gtgataatgc
    24301 ggcgaggttt ctcgccaccg gggcggcggt ggccggcgcg gcggctgtcc tggtccgggc
    24361 gaccggtgcc gcagcggctc tgtgacccgc cggaaagctg tgtcccgcat ctattttccc
    24421 gctctccggg tggcccggtg ggcggggcga atggtggcgg tcgtggcacc cgtgcgctcg
    24481 cggtccggcg tggtcgtgca actccgtgcg g
//
