LOCUS       NZ_BBNO01000004        21062 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000004
VERSION     NZ_BBNO01000004.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1029288)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 767794
            Orig. end                         :: 788856
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21062
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21062
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21062
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11062](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11062
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(289..1446)
                     /locus_tag="TU31_RS16520"
                     /old_locus_tag="TPA0598_04_06910"
     CDS             complement(289..1446)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969014.1"
                     /locus_tag="TU31_RS16520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06910"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_042154996.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.6e-31, bitscore:
                     103.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.9e-25, bitscore:
                     83.7, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.5e-45, bitscore:
                     148.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRTVFNEDHEAFRETIRAFIEAEVVPVHDEWLAAGQAPRDFYYK
                     LGELGVFGIRVPEEFGGAGIDSHKFEAVMYEETSRAGVSFGGSGVHVLLGLPYIQMLAT
                     DEQKKRFLPKFVSGEEMWALAMTEPGTGSDLAGMKSTAKLSEDGTHYVLNGAKTFITGG
                     VHADRVIVCARTAAPREDDRRFGISLFAVDAKSAGYSVGRKLDKLGLKISDTAELAFVD
                     VKVPVEDLLGEENKGFAYLGLNLASERWGIAFGAYAQAKAAVRFAKEYVQERTIFGKTV
                     ASFQNTKFELAACQAEVDAAEAVADRALEALDAGELTPAEAASAKLFCTEVAHRVIDRC
                     LQLHGGYGFMNEYPIARLYADNRVNRIYGGTSEVMKSIIAKSMGL"
     gene            complement(1576..2217)
                     /locus_tag="TU31_RS16525"
                     /old_locus_tag="TPA0598_04_06920"
     CDS             complement(1576..2217)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093080.1"
                     /locus_tag="TU31_RS16525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06920"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_042154998.1"
                     /transl_table=11
                     /translation="MSNAQSAAPTSRREQILKEAARLFAERGFHGVGVDEIGAAVGISG
                     PGLYRHFAGKDAMLAELLVGISERLLAGGRMRVAEGGGSPEAVLDALIDGHIDFALDDR
                     PLITLHDRELDRLREADRKRVRQLQRQYVELWVEVVRRVHPGPSESRARAAVHAVFGLL
                     NSTPHLGRPGALPGRTEMAELLHRLALGAFGAVAGEPEAGEPVAASVPGA"
     gene            2352..3983
                     /locus_tag="TU31_RS16530"
                     /old_locus_tag="TPA0598_04_06930"
     CDS             2352..3983
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010062850.1"
                     /locus_tag="TU31_RS16530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06930"
                     /product="carboxyl transferase domain-containing protein"
                     /protein_id="WP_042155000.1"
                     /transl_table=11
                     /translation="MEQAPVLGSTADPASDSWRANEAAHRELAAQLREKLAAARLGGGE
                     KARARHTARGKLLPRDRVDALLDPGSPFLELAPLAADGMYGGAAPAAGVIAGIGRVSGR
                     ETVIVANDATVKGGTYYPMTVKKHLRAQEIALENRLPCLYLVDSGGAFLPMQDEVFPDR
                     EHFGRIFYNQARMSGAGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRNQGTIFLGGPPLV
                     KAATGEVVTAEELGGGEVHAKTSGVTDHLAEDDAHALRLVRTIVGTLGERAPLPWTVRT
                     VEEPKADPAGLYGAVPADSRTPYDVREVIARLVDGSRFAEFKAEYGTTLVTGFAHIHGH
                     PVGIVANNGILFSESAQKGAHFIELCDQRGIPLLFLQNISGFMVGRSYEAGGIAKHGAK
                     MVTAVACTRVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNAKISVMGGEQAASVLA
                     TVKRDQLEAHGEEWSAEDEAAFKAPVREQYETQGNAYYATARLWDDGVIDPLETRQVLG
                     LALTACANAPLPQKDSTAPGYGVFRM"
     gene            4001..6004
                     /locus_tag="TU31_RS16535"
                     /old_locus_tag="TPA0598_04_06940"
     CDS             4001..6004
                     /EC_number="6.4.1.2"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605451.1"
                     /locus_tag="TU31_RS16535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06940"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_042155001.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 5e-10, bitscore:
                     34.9, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTNFDTVLIANRGEIAVRVIRTLRALGIRSVAVYSDADAGARHV
                     READTAVRIGPAPAAESYLSVERLLDAAARTGAQAIHPGYGFLAENAGFARAVAAAGLV
                     FIGPSAEAIELMGDKIRAKETVREAGVPVVPGSSGSGLDDGQLAAAAREIGMPVLLKPS
                     AGGGGKGMRLVREEALLADEIASARREARSSFGDDTLLVERWIDRPRHIEIQVLADGHG
                     NVIHLGERECSLQRRHQKVIEEAPSVLLDEATRAAMGEAAVQAARSCGYRGAGTVEFIV
                     PGKDPASYYFMEMNTRLQVEHPVTEMVTGIDLVEWQLRVAAGEPLPYAQEDITLTGHAI
                     EARICAEDPARDFLPTGGTVLALHEPQGGGVRTDSGLSEGGEVGSRYDPMLSKVIAHGP
                     DRASALRRLRAALAETVTLGVTTNAGFLRRLLAHPDVVSGELDTGLVEREAAGLVDGAV
                     PDEVYAAAAAVRQAALEPAVADGGWRDPFSAPNGFRLGGEPAPVRHWLRVPGHDPVPHD
                     VRPTAPAGQLEPGRVRVTVDGVLHTFHHSGDWLGRDGDSWQVTTHDPVAAALRGAAGAH
                     GADTLAAPMPGTVTVVKVAVGDEVAAGQGLLVVEAMKMEHVISAPHAGTVTELDVTAGS
                     TVAMDQILAVVAPHESPDEAAASAPGGGQESA"
     gene            6004..6945
                     /locus_tag="TU31_RS16540"
                     /old_locus_tag="TPA0598_04_06950"
     CDS             6004..6945
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093083.1"
                     /locus_tag="TU31_RS16540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06950"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_042155003.1"
                     /sec_met_domain="HMGL-like (E-value: 6.6e-48, bitscore:
                     159.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAGLPMEIRSEGLPTRVRIHEVGARDGLQNERTVVPTEVKAEF
                     IHRLAAAGLPTVEATSFVHPKWVPQLADAEQLFPLLGDLDPQRLPVLVPNERGLDRALA
                     LGARRIAVFGSATESFAKANLNRTVDEALAMFAPVITRAKDAGVEVRGYLSMCFGDPWE
                     GPVPVAQTVRVCRALLDLGCDELSLGDTIGVATPGHVQTLLAALNEAGVPTSRIGVHFH
                     DTYGQALANTFAALQHGITTIDASAGGLGGCPYAKSATGNLATEDLVWMLHGLGIETGV
                     DLDRLTATSVWMAEALGRPSPSRTLRALSHKE"
     gene            6951..8108
                     /locus_tag="TU31_RS16545"
                     /old_locus_tag="TPA0598_04_06960"
     CDS             6951..8108
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093084.1"
                     /locus_tag="TU31_RS16545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06960"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_181018614.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.3e-38, bitscore:
                     127.1, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.1e-22, bitscore:
                     74.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3e-50, bitscore:
                     166.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDHRLPDELEELRRTVEAFAHDVVAPKIGEYYEQHAFPYEIVQ
                     EMGRMGLFGLPFPEEYGGMGGDYLALGIALEELARVDSSVAITLEAGVSLGAMPVYHFG
                     TEEQKREWLPKLCSGEMLGAFGLTEPDGGSDAGATRTTAVRDGGDWVINGSKCFITNSG
                     TDITGLVTVTAVTGRKDDGSPLISSIIVPSGTPGFTVGAPYSKVGWSASDTRELSFSDV
                     RVPAANLLGEEGRGYAQFLRILDEGRIAIAALATGLAQGCVDESVRYAKERHAFGRAIG
                     SNQAIQFKLADMEMRAHTSRLAWRDAASRLVHGEPFKKEAALAKLYSSEIAVDNAREAT
                     QIHGGYGFMNEYPVARMWRDAKILEIGEGTSEVQRMLIARELGVV"
     gene            8539..9981
                     /locus_tag="TU31_RS16550"
                     /old_locus_tag="TPA0598_04_06980"
     CDS             8539..9981
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576907.1"
                     /locus_tag="TU31_RS16550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06980"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_042155005.1"
                     /transl_table=11
                     /translation="MSVPDGVTGSTTEEPALAPPADSALTSLSTQAARQLATTTKSEPQ
                     MQAITSRWLLKTLPWVDVKGGAYRVNRRLTLRVGRGRVQFEQNGADDIRVIPQTLTELP
                     VLRGYPDTEVLKELAGRFRVREVRPGQVLFEAGQPATEAYLVVHGRFARYTVGKYGEEE
                     VIDVVTDGDQMGDEAIGRPDPRWLSSVRAETAGVLLVLPWDVIREFTDRVPSLAAHLTA
                     YAERQQRPMNRKGEAEVPVQAGHVGEPTLSSGFVDYDLSPREYELSLTQTVLRVHSRVA
                     DLYNDPMDQTQQQLRLTVEEIRERQEWEMVNNREFGLLHNADYGQRISTYTGPPTPDDM
                     DELLSMRRKTRLFLAHPKAIAAFFRQCNKRGLVPGTANVDGHEVPAWRGVPIYPCGKIP
                     ISDTHTSSILALRTGEADQGVVGLHQTGIPEEYQPGLNVRFMGIDPSAVISYLVTAYYS
                     LAILVPDAVGVLENVQIGRNAD"
     gene            10001..11062
                     /locus_tag="TU31_RS16555"
                     /old_locus_tag="TPA0598_04_06990"
     CDS             10001..11062
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093087.1"
                     /locus_tag="TU31_RS16555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_06990"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_042155559.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-52, bitscore: 175.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPPNTAPTWSLPGPPNLAHTLRTRRPDGAVPGLRYRPVAPADP
                     EKAAEIDRRLEAWARALDLFPAQWTGDFTEFQFGRAVVLQHPGAADLERLTVAGKLLLA
                     ENIVDNCYCEEDEGKGGAHRGLGGRLIMAQSALDPLHGTPELEEEWRHGVQADGPLRSY
                     HWALKDYAALATPSQTDRFVHDIARLHLGYLAEAAWAETRHTPRVWEYLVMRQFNNFRP
                     CLSIVDAVDGYELPEALYARPEVQRVTALACNATTIVNDLYSFTRELASDPHHLNLPQV
                     VAANDQRGLKDAYLKSVEIHNQVMAAFERESAPLSATSPLLERYVRSLADWVSGNHEWH
                     ATNTDRYQLPHYW"
     gene            11095..11970
                     /locus_tag="TU31_RS16560"
                     /old_locus_tag="TPA0598_04_07000"
     CDS             11095..11970
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574303.1"
                     /locus_tag="TU31_RS16560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07000"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_042155007.1"
                     /transl_table=11
                     /translation="MTITHADTARTPVPTQSTYQSRVADYWNAEENPVNLELGKIDDLY
                     HHHYGIGDADRSVLNEPDPGRRRELVTGELHRLEHAQAELLASHLGDVSPTDRVFDAGC
                     GRGGGSVVANLRYGCHTDGATISAKQAEFANAQARKRGIDDKVRYHHRNMLDTGFTSGA
                     YAASWNNESSMYVELDLLFAEHARLLRRGGRYVVITGCYNDAYGRASREVSLINAHYIC
                     DIHPRSAYFHAMSRNRLVPVHVEDLTQAALPYWELRREADHLVTGIEETFLTAYRNGSF
                     QYLMIVADRV"
     gene            complement(12020..13624)
                     /locus_tag="TU31_RS16565"
                     /old_locus_tag="TPA0598_04_07010"
     CDS             complement(12020..13624)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093090.1"
                     /locus_tag="TU31_RS16565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07010"
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="WP_042155009.1"
                     /transl_table=11
                     /translation="MRRRRLLFSLLLVAAAGLGTAAVPPQGAAEAAPRAAIPLDRVIPA
                     PASVRDGGDAYTLGDRTRIRVPGGSGEAKRIAGYLAGLLRPATGLALPVTTKDGRDGIV
                     LRLGGSGTGGLGAEGYRLTSDGRAVTVRAARPAGLFHGVQTLRQLLPAEAEGQRAARGP
                     WRIAGGTIADSPRYGYRGAMLDVSRHFFTVAQVKRYIDQLAMYKINRLHLHLSDDQGWR
                     IAIKSWPRLATYGGSTQVGGGRGGYYTKDDYREIVRYAAARYLTVVPEIDMPGHTNAAL
                     ASYAPLNCNGQAPPLYTGTEVGFSSLCVPKQETYDFVDDVIRELAALTPGRYLHIGGDE
                     AHSTSHADYVAFMDKVQPVVAKYGKTVIGWHQLTGAHPAEGAVAQYWGYDKTGAAERQQ
                     VADAARNGTRLILSPADRAYLDMKYDKSTPLGLSWAGYVEARRSYDWDPGRYLQGAPAD
                     SVLGVEAPLWSETLSTSAHIEYMAFPRLPGIAELGWSPASTHDWDDYKVRLAAQGPRWD
                     ALGINYYRSPEVPWPAR"
     gene            13814..14104
                     /locus_tag="TU31_RS16570"
                     /old_locus_tag="TPA0598_04_07020"
     CDS             13814..14104
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574541.1"
                     /locus_tag="TU31_RS16570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07020"
                     /product="hypothetical protein"
                     /protein_id="WP_042155011.1"
                     /transl_table=11
                     /translation="MLERRHRSAEAPHEDLVDHLVRSSPLQRGEAARVVLDVLAYFDET
                     TEEFVRRRHRELQSQGLRNEAIFERIRHEMPHRAVAPPDLSSRQLRRIVYG"
     misc_feature    13863..13878
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            14171..16000
                     /gene="glmS"
                     /locus_tag="TU31_RS16575"
                     /old_locus_tag="TPA0598_04_07030"
     CDS             14171..16000
                     /EC_number="2.6.1.16"
                     /GO_function="GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA]"
                     /GO_process="GO:1901137 - carbohydrate derivative
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="glmS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980526.1"
                     /locus_tag="TU31_RS16575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07030"
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="WP_042155014.1"
                     /sec_met_domain="GATase_7 (E-value: 2.3e-16, bitscore:
                     55.6, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIVGYIGKRDVAPLLLEGLQRLEYRGYDSAGIAIHAKGTGKAA
                     GGLKTAKAKGRVRELESRLPKRFAGSTGIAHTRWATHGAPTDENAHPHRDTEGKVAVVH
                     NGIIDNAADLRARLTAEGVVFASETDTEVLAHLIGRSTAEKLEERVREALRHIEGTYGI
                     AVLHADFPDRIVVARNGSPVVLGIGEHEMFVSSDVAALVSHTRQVVTLDDGEMATLKAD
                     DYRTYTTEGSRTTSAPETVEYAAESYDLGGHDTYMHKEISEQADAVDRALRGRIDDRFS
                     TVHLGGLNLDAREARGVRRVKILGCGTSYHAGQIGAQMIEELARIPSDAEPASEFRYRN
                     PVVDPDTLYVAVSQSGETYDVLAAVQELKRKGARVLGLVNVVGSAIARETDGGIYVHAG
                     PEVCVVSTKCFTNMVVSFALLALHLGRIRDLSVADGKRIIEGLRKLPAQIDEILKGEED
                     IKKLSAAYADAKSMMFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEP
                     AMPTVAIVPDDDLLEKNRAALEEIKARSGRILAVAHQEQEKADHTIVVPKNEPELDPIL
                     MGIPLQLLAYHTALALGRDIDKPRNLAKSVTVE"
     misc_feature    complement(14192..14206)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(16481..17002)
                     /locus_tag="TU31_RS16580"
                     /old_locus_tag="TPA0598_04_07040"
     CDS             complement(16481..17002)
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105726.1"
                     /locus_tag="TU31_RS16580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07040"
                     /product="universal stress protein"
                     /protein_id="WP_018093093.1"
                     /transl_table=11
                     /translation="MAGHEIPEPADRKQVADPMADLEAAEKTRHSCDPAFRHGVVVGFD
                     GSMSSERALAYAIGMARRLGSGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLGLE
                     LACADHLTEVPWILVERGGDICHELEEVGREYEADAIVVGSTHGIVGRIFGSVAGRLAR
                     RAQRPVIVIP"
     misc_feature    17129..17144
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    17131..17145
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.57"
                     /tool="antismash"
     gene            17401..17673
                     /locus_tag="TU31_RS16585"
                     /old_locus_tag="TPA0598_04_07050"
     CDS             17401..17673
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605444.1"
                     /locus_tag="TU31_RS16585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07050"
                     /product="hypothetical protein"
                     /protein_id="WP_078885812.1"
                     /transl_table=11
                     /translation="MSDVVRWGAFSCALVPLVLIFSGASWAGAAGAAAGLAAVTCACRA
                     LLRHSERTAARVRVREVGRHRDRSGRSGTTAHGGGRHSEGRTPVD"
     misc_feature    17698..17712
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.26"
                     /tool="antismash"
     misc_feature    17852..17865
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.23"
                     /tool="antismash"
     gene            18023..19303
                     /locus_tag="TU31_RS16590"
                     /old_locus_tag="TPA0598_04_07060"
     CDS             18023..19303
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006349169.1"
                     /locus_tag="TU31_RS16590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07060"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_042155019.1"
                     /transl_table=11
                     /translation="MSQDSAAVPDAARKLAARRRREIVAVLLFSGGPIFESSIPLSVFG
                     IDRQDAGVPRYRLLVCAGEDAPLRTTGGLELSAPYGLEAISRAGTVVVPAWRSITQAPP
                     PAALDALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVDP
                     RELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGADAANALARRLVVPPRRTASDMGHQRY
                     LDRSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQ
                     WLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGASPAAYRAAYRARR
                     PQNGGPEPALRPERAERPERERAMLGAGSGERYAAAALAGHGLATAEAAEAGKPQSDAY
                     ASRLPESPVGRGPGRPVLPGQRERPVG"
     misc_feature    18701..18703
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19309..19926
                     /gene="orn"
                     /locus_tag="TU31_RS16595"
                     /old_locus_tag="TPA0598_04_07070"
     CDS             19309..19926
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0000175 - 3'-5'-RNA exonuclease activity
                     [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="orn"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542190.1"
                     /locus_tag="TU31_RS16595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_04_07070"
                     /product="oligoribonuclease"
                     /protein_id="WP_042155020.1"
                     /transl_table=11
                     /translation="MNDRMVWIDCEMTGLSLANDALIEVAALVTDSELNVLGDGVDVVI
                     RPPAEALGTMPEVVRQMHTASGLLEELDGGTTLEAAEAQVLAYIKQHVPEPGKAPLCGN
                     SVGTDRGFLLRDMPTLESYLHYRIVDVSSVKELARRWFPRAYFNSPDKNGNHRALADIR
                     ESIAELRYYREAVFVPQPGPDSDTAKAIAAKHVLPAEPQSTP"
     misc_feature    complement(20029..20047)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     misc_feature    complement(20037..20048)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.87"
                     /tool="antismash"
     tRNA            20089..20164
                     /anticodon=(pos:787916..787918,aa:His,seq:gtg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="TU31_RS16600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="TPA0598_04_t0100"
                     /product="tRNA-His"
     gene            20089..20164
                     /locus_tag="TU31_RS16600"
                     /old_locus_tag="TPA0598_04_t0100"
     misc_feature    20705..20723
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.89"
                     /tool="antismash"
     misc_feature    20870..20883
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.16"
                     /tool="antismash"
ORIGIN
        1 gggtggtgaa ggaccggccg tcgcggatgc ggtcgacggt gtagacgatg ggcgcgccgg
       61 ggtctcccgg gcgcaggaag tacgcgtgca gggagtgcgg cggccggtcg gcggggaccg
      121 tgcgcccggc cgcgaccagg gcctgggcgg cgacctggcc gccgaagacc cggggtacga
      181 ccgaggcacg gctctcgccc cggaagatgt cctgctcgat ccgctccagt gcgagcagat
      241 cgagcaggga ccggagtgcg tcgttcacgt gcgcggtgcc cttacggcct agaggcccat
      301 ggacttggcg atgatggact tcatgacctc gctggtgccg ccgtagatgc ggttgacgcg
      361 gttgtcggcg tagaggcggg cgatcgggta ctcgttcatg aagccgtagc cgccgtgcag
      421 ctggaggcag cggtcgatga cgcggtgggc gacctcggtg cagaacagct tggcggaggc
      481 ggcctcggcc ggggtcagct cgccggcgtc cagcgcttcg agcgcgcggt cggcgacggc
      541 ctcggcggcg tccacctcgg cctggcaggc ggccagttcg aacttggtgt tctggaagga
      601 ggcgaccgtc ttgccgaaga tcgtgcgctc ctgcacgtac tccttggcga accggacggc
      661 ggccttggcc tgggcgtacg cgccgaaggc gatgccccag cgctcggagg cgaggttcag
      721 gcccaggtag gcgaagccct tgttctcctc gccgagcagg tcctcgaccg ggaccttgac
      781 gtcgacgaag gccagctcgg cggtgtcgga gatcttcagg ccgagcttgt ccagcttgcg
      841 gccgacggag tagcccgcgg acttggcgtc cacggcgaag agcgagatac cgaagcggcg
      901 gtcgtcctcg cggggggccg cggtgcgggc gcagacgatg acgcggtcgg cgtgcacccc
      961 gccggtgatg aaggtcttgg cgccgttgag gacgtagtgc gtgccgtcct ccgacagctt
     1021 cgcggtggac ttcatgccgg cgaggtcgga gccggtgccc ggctcggtca tcgccagcgc
     1081 ccacatctcc tcgccgctga cgaacttcgg caggaagcgc ttcttctgct cgtcggtggc
     1141 gagcatctgg atgtacggga ggccgagcag gacgtgcacg ccggagccgc cgaaggagac
     1201 gcccgcgcgg gaggtctcct cgtacatcac ggcctcgaac ttgtgcgagt cgatgccggc
     1261 gccgccgaac tcctcgggga cgcggatgcc gaagacgccc agctcaccga gcttgtagta
     1321 gaagtcgcgc ggggcctggc cggcggcgag ccactcgtcg tgcacgggca cgacctcggc
     1381 ctcgatgaag gcgcgtatgg tctcgcggaa cgcctcgtga tcctcgttga acaccgtacg
     1441 gcgcattgct acgtcgcctc ctccaggtcg ccggtccaag cgcatggcta agcgcttgct
     1501 cagcgaaagc taccggccag ttacctaggc tgtccagagg tcaacgaaaa tccgtgcgag
     1561 ccggtgggcc cgcccctagg cgcccggcac cgacgccgcc accggctccc cggcctccgg
     1621 ctcccccgcc accgcgccga aggcacccag cgccagccgg tgcagcagct ccgccatctc
     1681 cgtacggccc gggagcgcgc ccggccggcc gaggtgcggg gtggagttga gcagaccgaa
     1741 gacggcgtgc accgcggcgc gggcccggga ctcggagggg cccgggtgga cccggcggac
     1801 gacctccacc cagagctcca catactgccg ctggagctgg cggacccgct tgcggtcggc
     1861 ctcccgcagt cggtccagct cccggtcgtg cagggtgatc agcggccggt cgtccagcgc
     1921 gaagtcgata tggccgtcga tcagcgcgtc cagcaccgcc tcggggctgc cgccgccctc
     1981 cgcgacccgc atccggccgc ccgcgagcag ccgctcgctg atcccgacca gcagctcggc
     2041 gagcatcgcg tccttgccgg cgaagtgccg gtagaggccc ggaccggaga tgcccacggc
     2101 cgcccctatc tcgtccacgc cgacaccgtg gaagccacgc tccgcgaaga gccgggcggc
     2161 ctccttgagg atctgctcgc ggcggctggt cggggcggcg gactgcgcat tactcatgcc
     2221 gtcgattgta gacagccggg ttagtgctcg ttaacctgaa ggcaatgagg ttaacgccca
     2281 ttaacccgga tggcccggac gccgcggacc gcggcaccgg ggcaggtgat cgagcaaggg
     2341 ggctcgtact gatggagcag gcaccggtgc tggggagtac cgccgatccg gcgtccgact
     2401 cctggcgggc caatgaggcc gcgcaccgcg agctggccgc acagctgcgc gagaagctcg
     2461 cggcggcccg gctgggcggc ggcgagaagg ccagggcgcg gcacaccgcc cgcggcaaac
     2521 tgctgccccg cgaccgggtg gacgccctgc tggacccggg ctcgccgttc ctggagctgg
     2581 cgccgctggc cgcggacggg atgtacggcg gggccgcacc ggccgcgggc gtgatcgccg
     2641 gcatcggccg ggtctccggc cgcgagacgg tgatcgtcgc caatgacgcc acggtcaagg
     2701 gcggcacgta ctacccgatg acggtcaaga agcatctgcg ggcgcaggag atcgccctgg
     2761 agaaccgtct cccctgtctt tacctggtgg actccggcgg ggccttcctg ccgatgcagg
     2821 acgaggtctt ccccgaccgg gagcacttcg ggcggatctt ctacaaccag gcgcggatgt
     2881 cgggcgccgg aatcccgcag atcgccgccg tcctcggatc ctgcacggcc ggtggcgcct
     2941 acgtccccgc catgagcgac gaggccgtga tcgtccgcaa ccagggcacg atcttcctgg
     3001 gcgggccgcc gctggtgaag gccgccacgg gcgaggtggt caccgccgag gagctgggcg
     3061 gcggcgaggt gcacgccaag acctcgggcg tcaccgacca tctcgccgag gacgacgccc
     3121 atgcgctgcg cctggtgcgc accatcgtcg gaaccctcgg cgagcgcgcg ccgctcccgt
     3181 ggaccgtgcg gaccgtcgag gagcccaagg ccgacccggc cggtctgtac ggggcggtgc
     3241 ccgcggactc ccgtacgccc tatgacgtcc gggaggtgat cgcccggctg gtggacggct
     3301 cgcgcttcgc ggagttcaag gcggagtacg ggacgacgct ggtcaccggc ttcgcccata
     3361 tccacggcca cccggtcggc atcgtcgcca acaacggcat cctgttctcc gaatccgccc
     3421 agaagggcgc ccacttcatc gagctgtgcg accagcgcgg tatcccgctg ctgttcctcc
     3481 agaacatctc cggcttcatg gtggggcgtt cgtacgaggc cggcgggatc gccaagcacg
     3541 gcgcgaagat ggtgacggcg gtggcctgca cccgcgtgcc caagctgacg gtcgtcatcg
     3601 gcggctccta cggggcgggc aactactcca tgtgcggacg cgcctattcg ccgcgcttcc
     3661 tgtggatgtg gccgaacgcc aagatctcgg tgatgggcgg cgaacaggcc gcctccgtcc
     3721 tcgcgaccgt caagcgggac cagctggagg cgcacggcga ggagtggagc gccgaggacg
     3781 aggccgcctt caaggcgccg gtccgcgagc agtacgagac ccagggcaac gcctactacg
     3841 cgaccgcgcg gctgtgggac gacggtgtga tcgacccgct ggagacccgg caggtgctgg
     3901 ggctggcgct gacggcctgt gccaacgcgc cgctccccca gaaggacagc accgcgcccg
     3961 gctacggcgt cttccggatg tgagagggat gtccccagca atggtcacca acttcgacac
     4021 cgtgctcatc gccaaccgcg gcgagatcgc ggtccgtgtc atccgtacgc tgcgcgccct
     4081 cggcatccgc tcggtcgccg tttacagcga cgcggacgcc ggtgcccgcc atgtccgcga
     4141 ggccgacacc gccgtacgga tcggtccggc cccggccgcc gagagctatc tgtccgtgga
     4201 acggctgctg gacgcggccg cccggaccgg cgcccaggcg atccacccgg gctatggctt
     4261 cctcgccgag aacgccggct tcgcccgtgc cgtggcggcg gccgggctgg tcttcatcgg
     4321 cccgtccgcc gaggccatcg agctgatggg cgacaagatc cgcgccaagg agacggtgcg
     4381 ggaggccggg gtcccggtcg tgcccggctc ctcgggcagc gggctggacg acggtcaact
     4441 ggccgccgcg gcacgcgaga tcggcatgcc ggtgctgctc aagccgtccg cgggcggcgg
     4501 cggcaagggc atgcggctgg tccgcgagga agcgctgctg gccgacgaga tcgcttccgc
     4561 ccgccgggag gcccgctcct ccttcggcga tgacaccctg ctcgtcgagc gctggatcga
     4621 ccggccccgg cacatcgaga tccaggtgct ggcggacggc cacggcaatg tcatccatct
     4681 cggcgagcgc gagtgctccc tccagcgccg ccaccagaag gtcatcgagg aggccccctc
     4741 ggtcctgctg gacgaggcca cccgcgccgc gatgggcgag gcggccgtgc aggcggcccg
     4801 ctcctgcggc taccggggcg ccggcaccgt ggagttcatc gtcccgggca aggacccggc
     4861 ctcctactac ttcatggaga tgaacacccg cctccaggtc gagcacccgg tcaccgagat
     4921 ggtcaccggt atcgacctgg tggagtggca gctgcgggtc gcggccggcg aaccgctccc
     4981 gtacgcccag gaggacatca ccctcaccgg gcacgccatc gaggcccgga tctgcgccga
     5041 ggacccggcc cgcgacttcc tgccgaccgg cggcacggtc ctcgcgctcc acgagccgca
     5101 gggcggcgga gtgcgcaccg actccgggct ctcggagggc ggggaggtcg gcagccgcta
     5161 cgacccgatg ctgtccaagg tgatcgccca cggtccggac cgggcgagcg cactgcgccg
     5221 gctccgggcc gcgctggccg agaccgtcac cctcggcgtc accaccaacg ccggtttcct
     5281 gcggcggctg ctggcccacc ctgacgtggt ctccggcgag ctggacaccg gcctggtgga
     5341 gcgggaggcg gccggtctgg tcgacggcgc ggtgccggac gaggtgtacg cggcggccgc
     5401 ggcggtacgg caggccgccc tggaaccggc agtggccgac ggcggctggc gcgacccgtt
     5461 ctcggccccg aacggcttcc ggctcggcgg cgagcccgcg ccggtccgcc actggctgcg
     5521 ggtcccggga cacgacccgg tgccgcacga cgtacggccc acggccccgg ccggacagct
     5581 ggagccgggc cgggtacggg tcaccgtcga cggggtgctg cacaccttcc accacagcgg
     5641 cgactggctc ggccgggacg gcgactcctg gcaggtgacc acccacgacc cggtggccgc
     5701 ggcgctgcgc ggtgccgccg gggcacacgg cgcggacacc ctggccgccc cgatgcccgg
     5761 caccgtcacc gtcgtcaagg tcgccgtcgg cgacgaagtg gccgcgggcc agggcctgct
     5821 ggtggtggag gcgatgaaga tggagcacgt catctccgca ccgcacgccg gcaccgtcac
     5881 cgaactcgac gtcaccgcgg gctcgaccgt cgccatggac cagatcctgg ccgtggtcgc
     5941 cccgcacgag agccccgacg aggccgccgc gagcgccccc gggggcgggc aggagagcgc
     6001 ctgatgaccg cagccggact gccgatggag atccgctcgg agggactgcc cacccgcgta
     6061 cggatccatg aggtcggcgc gcgcgacggg ctgcagaacg agcggacggt ggtgcccacg
     6121 gaggtcaagg cggagttcat ccaccggctc gccgccgcgg gcctgccgac cgtcgaggcc
     6181 accagcttcg tccaccccaa gtgggtgccc caactcgccg acgccgagca gctgttcccg
     6241 ctgctgggcg atctcgatcc gcagcggctg ccggtgctgg tccccaacga gcgcgggctg
     6301 gaccgggcgc tggcgctggg ggcccgccgg atcgcggtgt tcggcagcgc caccgagtcg
     6361 ttcgccaagg ccaacctcaa ccggacggtc gacgaggcgc tggcgatgtt cgcgccggtg
     6421 atcacgcggg ccaaggacgc cggggtggag gtgcgcggct atctctcgat gtgcttcggc
     6481 gacccctggg agggcccggt gcccgtcgcg cagaccgtcc gggtctgccg ggcactgctc
     6541 gacctgggct gcgacgaact gagcctgggc gacaccatcg gggtggccac ccccggtcat
     6601 gtgcagaccc tgctggccgc cctcaacgag gccggggtgc ccacctcccg tatcggcgtg
     6661 cacttccacg acacctacgg gcaggccctc gccaacacct tcgccgcgct ccagcacggc
     6721 atcaccacca tcgacgcctc ggcgggcggc ctcggcggct gcccgtatgc caagagcgcc
     6781 accggaaacc tcgccaccga agacctcgtg tggatgctgc acggcctcgg tatcgagacc
     6841 ggggtcgacc tggaccgtct gaccgccacc agcgtgtgga tggccgaggc cctgggccgg
     6901 ccgagcccct cgcgtaccct ccgtgccctc tcccacaagg agtgaccctc atgtccctgg
     6961 accaccgcct gcccgacgag ctggaagaac tccggcgcac ggtcgaggcg ttcgcacacg
     7021 acgtcgtcgc cccgaagatc ggcgagtact acgagcagca tgcgttcccg tacgagatcg
     7081 tgcaggaaat gggccggatg ggcctgttcg ggctgccctt ccccgaggag tacggcggga
     7141 tgggcggcga ctacctcgcg ctcggcatcg ccctggagga gctggcccgg gtcgactcct
     7201 cggtggccat caccctggag gcgggcgtct ccctgggcgc catgccggtc taccacttcg
     7261 gcacggagga gcagaagcgg gagtggctgc ccaagctgtg cagcggtgag atgctcggcg
     7321 ccttcggcct caccgagccg gacggcggct cggacgccgg cgcgacgcgg acgaccgcgg
     7381 tgcgcgacgg cggggactgg gtgatcaacg gcagcaagtg cttcatcacc aactccggta
     7441 cggacatcac cggtctggtc acggtcaccg ccgtcaccgg ccgcaaggac gacggcagcc
     7501 cgctgatctc ctcgatcatc gtgccctccg gcaccccggg cttcacggtc ggcgccccgt
     7561 actccaaggt cggctggagc gcctcggaca cccgcgagct gtcgttctcc gatgtgcggg
     7621 tcccggccgc caacctgctg ggcgaggagg gccgcggcta cgcccagttc ctgcggatcc
     7681 tcgacgaggg ccggatcgcc atcgcggcgc tggccaccgg cctggcgcag ggctgtgtgg
     7741 acgagtcggt gcgctacgcc aaggagcggc acgccttcgg ccgcgccatc ggcagcaacc
     7801 aggcgatcca gttcaagctc gccgacatgg agatgcgcgc ccacacctcc cggctggcct
     7861 ggcgcgatgc cgcgtcccgg ctggtgcacg gcgagccctt caagaaggag gccgcactcg
     7921 ccaagctcta ctcgtccgag atcgcggtgg acaacgcccg cgaggccacc cagatccacg
     7981 gcggctacgg cttcatgaac gagtacccgg tcgcccggat gtggcgggac gccaagatcc
     8041 tggagatcgg cgagggcacc agcgaggtcc agcggatgct gatcgcccgg gagttgggcg
     8101 tcgtctaggg cgtcgcccgg ggcatggccc gggtgaagtg agtggtgggc ggtccggtcg
     8161 catcaggcga ccgggccgcc gccttttttg cgcttgtggc gccggtccgc cccggcccgt
     8221 ccgcccgccc ccgtccgccc ccgcgcccgc cggcgctgct cccgtccgcc cgctcgtccg
     8281 cccggcgccc gtccgccgcg gtgcgcggcc gcgcctgtac cccggtgcgt ccggagcatg
     8341 cggcggcgga agggcgtgcg ggcgcaccac catgatccgt ctgcaacacc cggaggttta
     8401 tgcctcgtgg atgcgaggtc gccccctttc acgccgtacc ggcacagctg tccctcctgt
     8461 ttggcttgct cctgcacgcg gccgctttgc tgaccaccgg ccgttttgct cacgtctgtt
     8521 catgtcccgg gagggaaagt gtccgtaccg gacggcgtca ccggttccac caccgaagag
     8581 cccgctctcg caccacccgc agacagtgcg ctcaccagcc tcagcaccca ggccgcgcgc
     8641 caactggcga ccaccaccaa gtccgagccc cagatgcagg ccatcacctc gcgatggctg
     8701 ctgaagacgc tgccctgggt ggacgtcaag ggcggcgcct accgggtcaa ccggcgcctg
     8761 acgctccgcg tcggccgggg ccgggtccag ttcgagcaga acggcgcgga cgacatcaga
     8821 gtgatccccc agacgctcac cgaactgccg gtcctgcgcg gctaccccga caccgaggta
     8881 ctcaaggagc tcgccggccg cttccgggtc cgggaggtcc ggcccggcca ggtcctcttc
     8941 gaggccgggc agcccgccac cgaggcgtac ctcgtcgtcc acggccgttt cgcccgctac
     9001 acggtcggca aatacggcga ggaggaggtc atcgacgtcg tcacggacgg cgaccagatg
     9061 ggggacgagg cgatcggccg gcccgacccg cggtggctga gctcggtccg ggccgagacg
     9121 gcgggcgtgc tgctggtgct gccctgggac gtgatccggg agttcaccga ccgggtgccg
     9181 tccctggccg cccatctgac ggcgtacgcg gagcggcagc agcgccccat gaaccgcaag
     9241 ggcgaggcgg aggtgccggt gcaggcgggg cacgtcggcg agccgacgct gtcatccggc
     9301 ttcgtcgact acgacctctc cccgcgcgag tacgagctct ccctgaccca gaccgtgctg
     9361 cgggtccaca gccgggtcgc cgatctctac aacgacccca tggaccagac gcagcagcaa
     9421 ctccggctca ccgtggagga gatccgcgag cgccaggagt gggagatggt caacaaccgg
     9481 gagttcggcc tgctgcacaa cgccgactac ggccagcgga tcagcaccta caccggcccg
     9541 cccacccccg acgacatgga cgagctgctg tccatgcgcc gcaagacacg gctgttcctg
     9601 gcccacccga aggcgatcgc cgccttcttc cggcagtgca acaaacgcgg actggtgccg
     9661 ggcacggcga acgtcgacgg gcacgaggta cccgcctggc gcggggtccc gatctacccg
     9721 tgcggcaaga tcccgatcag cgacacccac accagcagca tcctcgcgct gcgtaccggc
     9781 gaggcggacc agggagtcgt cggcctgcac cagaccggca tccccgagga gtaccagccc
     9841 ggcctgaacg tccggttcat gggcatcgac ccgtccgccg tcatcagcta cctcgtcacc
     9901 gcctactact cgctggccat cctcgtgccc gacgccgtcg gagtcctgga gaacgtccag
     9961 atcggccgga acgccgactg accaggtgga gtccctcacc atgagcaccc ccccgaacac
    10021 cgcccccacg tggtcgctgc ccggcccgcc gaacctcgcc cacaccctgc ggacccgccg
    10081 cccggacggc gccgtccccg ggctgaggta ccggcccgtc gcccccgccg acccggagaa
    10141 ggccgcggag atcgaccgca gactggaggc ctgggccaga gcgctggacc tgttccccgc
    10201 gcagtggacc ggggacttca ccgagttcca gttcggccgg gcggtcgtcc tccagcaccc
    10261 cggcgcggcc gacctcgaac gcctcaccgt cgcgggcaag ctgctgctgg ccgagaacat
    10321 cgtcgacaac tgctactgcg aggaggacga gggcaagggc ggcgcgcacc gtggcctggg
    10381 cggccggctg atcatggccc agtcggccct cgacccgctg cacggcaccc ccgagctgga
    10441 ggaggagtgg cgccacggcg tgcaggccga cggaccgctg cgctcgtacc actgggcgct
    10501 gaaggactac gcggcgctcg ccacccccag ccagaccgac cggttcgtcc atgacatcgc
    10561 ccggctgcac ctcggctatc tcgccgaggc cgcctgggcg gagacccggc atacgccgcg
    10621 ggtctgggag tacctggtca tgcggcagtt caacaacttc cgtccctgtc tgtccatcgt
    10681 cgacgccgtg gacggctacg aactgcccga ggcgctctac gcccgccccg aggtccagcg
    10741 ggtcaccgcg ctggcgtgca acgccacgac catcgtcaac gacctgtact ccttcaccag
    10801 ggaactggcg agtgacccgc accatctgaa cctgccccaa gtggtggccg ccaacgacca
    10861 acgcggcctg aaggacgcct acttgaagag cgtcgagatc cataaccagg tcatggcggc
    10921 gttcgagagg gagtcggccc cgctgtcggc cacctcaccc ctcctcgaac gctatgtccg
    10981 gagcctggcc gactgggtgt ccggcaacca cgagtggcac gccaccaaca ccgaccgcta
    11041 ccagctgccc cactactggt agaccgatcc gcgcaccaca gcaaggagcc accgttgacc
    11101 atcactcacg ccgacaccgc ccgcacaccg gtgccgaccc agtccacgta ccagtcccgg
    11161 gtcgcggact actggaacgc cgaggaaaac ccggtcaacc tcgaactcgg caagatcgac
    11221 gacctgtacc accatcacta cggcatcggg gacgccgacc ggtcggtgct gaacgagccg
    11281 gaccccggcc ggcgccggga actggtcacc ggtgaactgc accgcctgga acacgcccag
    11341 gccgagctcc tcgcctccca cctgggcgat gtctccccca ccgaccgcgt cttcgacgcc
    11401 gggtgcggcc gcggcggcgg cagcgtggtc gcgaatctgc gctacggctg ccacaccgac
    11461 ggcgccacga tctccgccaa gcaggccgaa ttcgccaacg cgcaggcccg caagcgcggt
    11521 atcgacgaca aggtgcgcta ccaccaccgc aacatgctcg acaccggctt cacctccggc
    11581 gcgtacgcgg cgtcctggaa caacgagtcg agcatgtacg tcgagctgga cctgctgttc
    11641 gccgagcacg cacggctgct gcggcgcggt ggccgctatg tggtgatcac cggctgctac
    11701 aacgacgcct acgggcgcgc ctcccgtgag gtgtccctca tcaacgccca ctacatctgc
    11761 gacatccacc cgcgctcggc gtacttccac gccatgtccc gtaaccgcct cgtccccgtg
    11821 cacgtcgagg acctgacaca ggccgcgctc ccgtactggg agctgcgccg ggaggccgac
    11881 cacctggtca cggggatcga ggagaccttc ctgaccgcgt accgcaacgg cagcttccag
    11941 tacctgatga tcgtcgccga ccgggtctga cggctccgcg gtccgtgccg ggcgtccgac
    12001 gacgcccggc acggccgtct caccgcgccg gccagggcac ttccggcgag cggtagtagt
    12061 tgatacccag cgcgtcccag cgcggcccct gggcggccag ccggaccttg tagtcgtccc
    12121 agtcatgggt gctcgccggg gaccagccca gctccgcgat gccgggcagc cgcgggaagg
    12181 ccatgtactc gatgtgcgcg gaggtggaga gcgtctcgga ccacaggggc gcctccactc
    12241 cgaggacgga gtccgcgggc gcgccctgga ggtagcggcc cgggtcccag tcgtaggagc
    12301 gccgggcctc gacatagccg gcccaggaca ggcccagcgg cgtgctcttg tcgtacttca
    12361 tgtcgaggta ggcgcggtcc gcgggcgaga ggatcagccg ggtgccgttc cgggcggcgt
    12421 cggcgacctg ctgccgctcc gccgcgcccg tcttgtcgta gccccagtac tgcgcgacgg
    12481 cgccctcggc cgggtgcgcc ccggtcagct ggtgccagcc gatcaccgtc ttgccgtact
    12541 tggccaccac cggctgcacc ttgtccatga aggccacata gtccgcatgg ctggtggagt
    12601 gcgcctcgtc gccgccgatg tggaggtagc ggccgggtgt cagggccgcg agttcgcgga
    12661 tgacgtcgtc cacgaagtcg taggtctcct gcttgggcac gcacagggag ctgaagccga
    12721 cctcggtgcc ggtgtagagc ggcggtgcct ggccgttgca gttgagcggg gcgtaggagg
    12781 ccagcgcggc gttggtgtgg cccggcatgt cgatctcggg gacgacggtc agatagcggg
    12841 ccgcggcgta gcggacgatc tcgcggtagt cgtccttggt gtagtagccg ccgcggccgc
    12901 cgccgacctg ggtggagccg ccgtaggtcg ccagccgtgg ccaggacttg atggcgatcc
    12961 gccagccctg gtcgtcggag aggtgcagat gcagccggtt gatcttgtac atggcgagct
    13021 ggtcgatgta ccgcttgacc tgcgccacgg tgaagaagtg ccgggagaca tcgagcatcg
    13081 cgccccggta gccgtagcgc ggggagtcgg cgatggtgcc cccggcgatc cgccagggcc
    13141 cgcgcgcggc gcgctgcccc tcagcctcgg cgggcagcag ctggcgcagg gtctgcacgc
    13201 catggaagag gccggccgga cgggcggccc tgacggtgac cgcacggccg tcggaggtca
    13261 gccggtagcc ctcggcgccc agcccgccgg tgccgctgcc gccgagccgc aggacgatgc
    13321 cgtcccggcc gtccttggtc gtgacgggga gggcgaggcc ggtggcgggc cgcagcagcc
    13381 ccgccagata gccggcgatc cgcttggcct cgccggagcc gccgggcacc cggatccggg
    13441 tgcggtcacc gagggtgtac gcgtccccgc cgtcgcgtac ggacgcgggc gcggggatca
    13501 cccggtccag tgggatcgcg gcccggggag cggcctcggc ggcgccctgc ggcggtacgg
    13561 cggcggtccc cagccccgcc gccgcgacca gcagcagcga gaacagcagt ctgcgtcgtc
    13621 tcatcgacgg tcccttcggc gaacctcgtg catggcatgg tgcatggcat ggagcgaccg
    13681 aacggtgacc atgcgtaccg tgagcctcga ttccggtcaa ggttcagacc actttccggc
    13741 ccccaaatcg gggacgtgcc cgatagcggg cagatttctt gcgattcctc gcgccgcccc
    13801 gcagtatcta cgggtgctcg aacgccgtca ccgcagcgct gaagcgccgc acgaagacct
    13861 ggtggaccac ctggtgcgca gctcaccgct tcagcgcggg gaggccgccc gggtggtgct
    13921 ggacgtgctg gcgtacttcg acgagaccac ggaggaattc gtccgccgtc gccatcggga
    13981 gctccagtcc cagggactgc gcaacgaggc gatcttcgaa cggatccgcc acgagatgcc
    14041 gcaccgcgcc gtggccccgc ccgatctctc gtcccgccag ctgcgccgca tcgtctacgg
    14101 ctgacgacca cgcccgggac gccgggcagc acgcaccatc gccacaacgc ttttctggga
    14161 gggtcactgt atgtgcggga tcgttggata catcggcaaa cgtgatgtcg ccccgctgct
    14221 cctcgaaggc cttcagcgcc tggagtaccg aggctacgac tccgcgggta tcgccatcca
    14281 cgccaagggc accggcaagg ccgcgggcgg cctgaagacc gccaaggcca agggccgggt
    14341 ccgcgagctg gagtcccggc tgcccaagcg cttcgcgggc tccaccggca tcgcgcacac
    14401 ccgctgggcc acccacggcg cgccgaccga cgagaacgcc cacccgcacc gggacaccga
    14461 gggcaaggtc gcggtcgtcc acaacggcat catcgacaac gccgccgacc tgcgcgcccg
    14521 gctgaccgcc gagggcgtcg tcttcgcctc cgagaccgac accgaggtcc tggcccacct
    14581 catcggccgg tccacggccg agaagctgga ggagcgggtc cgcgaggcgc tgcggcacat
    14641 cgagggcacc tacggcatcg ccgtcctgca cgccgacttc cccgaccgca tcgtggtggc
    14701 ccgcaacggc tccccggtcg tcctcggcat cggcgagcac gagatgttcg tctcctccga
    14761 cgtcgccgcg ctggtctcgc acacccgcca ggtcgtcacc ctcgacgacg gcgagatggc
    14821 cacgctcaag gccgacgact accgcacgta caccaccgag ggctcgcgga ccacgtccgc
    14881 tccggagacc gtcgagtacg cggccgagtc gtacgacctg ggcggccacg acacctacat
    14941 gcacaaggag atctccgagc aggcggacgc ggtggaccgc gcgctgcgcg gccggatcga
    15001 cgaccgcttc tccaccgtgc acctgggcgg cctgaacctc gacgcccgcg aggcgcgcgg
    15061 ggtgcgccgg gtgaagatcc tgggctgcgg cacctcgtac cacgcgggcc agatcggcgc
    15121 gcagatgatc gaggagctgg cccgtatccc ctcggacgcc gagccggcct ccgagttccg
    15181 ctaccgcaac ccggtcgtgg accccgacac gctgtacgtg gcggtctccc agtccggtga
    15241 gacctacgac gtgctggcgg ccgtccagga actcaagcgc aagggcgccc gggtcctggg
    15301 cctggtgaac gtggtcggct cggcgatcgc ccgggagacc gacggcggca tctacgtgca
    15361 cgccggcccc gaggtctgcg tggtctccac caagtgcttc accaacatgg tggtgtcctt
    15421 cgcgctgctc gccctgcacc tgggccggat ccgtgacctg tcggtcgcgg acggcaagcg
    15481 gatcatcgag ggcctgcgca agctgcccgc gcagatcgac gagatcctca agggcgagga
    15541 agacatcaag aagctgtcgg ccgcctacgc ggacgccaag tcgatgatgt tcatcggccg
    15601 ggtgcgcggc taccccgtgg cccgtgaggc ctctctgaag ctcaaggagg tctcctacat
    15661 ccacgccgag gcctacccgg cgtcggagct gaagcacggc ccgctggccc tcatcgagcc
    15721 cgcgatgccg accgtcgcga tcgtccccga cgacgacctg ctggagaaga accgcgccgc
    15781 gctggaggag atcaaggccc gcagcggccg catcctggcc gtcgcccacc aggagcagga
    15841 gaaggccgac cacaccatcg tcgtcccgaa gaacgagccc gagctggacc cgatcctcat
    15901 gggcatcccg ctgcaactgc tcgcctacca cacggcattg gccctcggcc gcgacatcga
    15961 caagccgcgc aacctggcca agtccgtcac ggtggagtaa cccaccccga ccgcctcacc
    16021 gagccggtga ccgtgaaggt ggtccacccc aggaccaccg aagcgagaat tgaggcaccc
    16081 ccacggcgct caaccacctc cgcgaaagcg gcgccggctt aggcgcaaag gccggggctc
    16141 cgcgcgtgcc accagcgcgc ggagccgccg cctccccttt gccggcgtcg cccatacgcc
    16201 ggcgggatgc cgccgccccg ggagccgtca cctcccggcc ggcagcacga agttgccgtg
    16261 cgcgcggccg ccgggcccgt gacgcggcgc gcccacgtga cggttttcta cccctcgcgg
    16321 acgcccggtg cacctggccg cgtcagcgga agtgcggctg cgcacaatcc tcatgacgcc
    16381 cccgcacctg tgtgcatgac ggggaggaag atcgcctgaa gaggcggtgc ggcacggcga
    16441 gttgagcgcc ctccgagggg cgggccgtcc cgagggtgcg tcagggaatc acgatcaccg
    16501 ggcgctgtgc ccggcgggcc agccggccgg ccaccgagcc gaagatccgg ccgacgatgc
    16561 cgtgcgtgga gccgaccacg atggcgtcgg cctcgtactc ccggccgacc tcctccagct
    16621 catggcagat gtccccgccg cgctcgacga ggatccaggg cacctcggtg aggtgatccg
    16681 cacaggccag ctccaggccg agcacttcgg tgcggtgatc cggtacgtcc acgaagacgg
    16741 ggggctcaca gcccgcccag acggtcgtcg gcagccggtt ggccacatgg acgatgatca
    16801 agccggagcc gaggcgccgg gccataccga ttgcatacgc caatgctcgt tcgctcgaca
    16861 tggagccgtc gaagccgacc acgacgccgt gccggaacgc ggggtcgcag gagtggcgcg
    16921 tcttttccgc cgcttcgagg tccgccatgg gatcggcgac ctgcttgcgg tccgcgggtt
    16981 cggggatttc gtgaccggcc attggtgtct cggcgaggac gtcctcttgc ggaggggcga
    17041 acggggaacg gcgattgact tgatccggca gttgactgag ctgactcgcc cgaagtgcgg
    17101 gagccatagt tcaaagagga acgatacgac tgggaatcat cttcccaacc cgatacccca
    17161 agagtacggc gccactcccc cgctgcccag agcccgccac ggacgcgggg cgcccgcgcg
    17221 aggtgggtgg ggcctcgaac gttccccgga gcatgccgga gcgtggcgcg gatggcaatg
    17281 ccccggcctg cccccgtacg tacccctcgc ggtgacccat gatcgtcggc cgcgttgtag
    17341 tagcagcccg tccgagggga gtgcgcggtg ccgttgccgt ccgacagatc acccgaccca
    17401 gtgagcgatg tggtgcgctg gggcgcgttc agctgtgccc tggtgcccct cgtcctgatc
    17461 ttcagcggcg cctcctgggc cggcgcggcc ggtgccgccg ccggtctggc cgcggtgacc
    17521 tgcgcctgtc gcgcactgtt gcggcattcc gaacggaccg cggcccgggt ccgtgtgcgc
    17581 gaggtcggac gacaccggga cagaagcgga cgttcaggga cgacggcgca cgggggcggc
    17641 cggcactccg aagggcgtac gccggtcgat tgaggcgtct gcaagtctgc gcgcgaccgt
    17701 tttcagccaa cttccggccg aggtccacac cttgcccgtg acccccctca accctggtgt
    17761 gagcagggag gaaaggaccg ctgggcatgg ttgtgcccta ctgcgaacgg gcagagccga
    17821 gacgcgtact tcccatgtag gcccgacgag tggaacgctt cgtgatcgaa tgcttcgcgc
    17881 caagttgcca tatcgacata ccagcgggtg gtgaacttgg cactccatcc tcacggaaca
    17941 cagtagattc gatcttggta gcaatggcgg gggaactgtg caggaccgag agggcgagac
    18001 gaccgagggg ggcttaagtg ccatgagcca ggactccgct gccgtaccag atgccgcacg
    18061 caagctcgcc gcccgacgac gccgcgaaat agtcgcggtg ctcctcttca gcggcggccc
    18121 cattttcgag agctccattc cgctctcggt cttcggcatc gaccgacagg acgcaggcgt
    18181 tccgcggtac cggctgcttg tgtgcgcggg cgaagatgcg cctttgcgca cgaccggggg
    18241 gctcgaactt tccgccccct acgggctgga ggcgatctcc cgtgccggga cggtcgtcgt
    18301 accggcctgg cgatccatca cccaggcccc gccgcccgcc gcgctcgacg cgctgcgccg
    18361 cgcgcatgaa gaaggggcca gaatcgtcgg gctgtgcacg ggggcgttcg tcctcgccgc
    18421 ggccggactg ctcgacggcc gcccggccac cacccactgg atgtacgcac cgacgctcgc
    18481 caagcgttac ccgtccgtcc atgtggaccc ccgcgagctc ttcgtcgacg acggcgatgt
    18541 gctcacgtcc gcgggaacgg cggccggtat cgacctgtgt ctgcacatcg tgcgcaccga
    18601 ccacggcgcg gacgccgcga acgcgctggc ccgccggctc gtcgtgccgc cccgccggac
    18661 cgcgtccgac atggggcacc agcgctacct ggacaggtca ttacctgaag agatcggcgc
    18721 cgacccgctc gccgaggtcg tcgcctgggc gctggagcat ctccacgagc agttcgacgt
    18781 ggagacgctg gccgcgcgtg cgtacatgag ccggcgcacc ttcgaccggc gcttccgctc
    18841 gctgaccggc agcgctccgc tccagtggct gatcacccag cgggtgctcc aggcccagcg
    18901 gctgctggag acctccgact attcggtgga cgaggtcgcc ggacgctgcg gcttccgctc
    18961 gccggtcgcc ctgcgcggcc acttccggcg acagctgggc gcctcgcccg cggcctaccg
    19021 tgcggcctac cgcgcgcgcc ggccgcagaa cggggggccc gagccagcgc tcagaccgga
    19081 gcgtgcggag cggccggagc gcgagcgggc gatgctcggc gcgggcagcg gggagcggta
    19141 cgccgccgcc gcgctggccg gccacgggct ggcgaccgcg gaagcggccg aagcgggcaa
    19201 accgcagtcg gacgcctacg cctcccggct gccggaatcc ccggtcggcc ggggtccggg
    19261 ccgccccgtg ctgcccggac agcgggagcg ccccgtaggg tgagatgtat gaacgatcgc
    19321 atggtgtgga tcgactgcga gatgaccgga ctctcgctgg cgaatgacgc gctcatcgag
    19381 gtggccgccc tggtcaccga ctcggagctg aatgtgctgg gcgacggggt ggatgtggtg
    19441 atccgccctc cggccgaggc gctcggcacc atgccggagg tggtgcgcca gatgcacacc
    19501 gcctccgggc tgctggagga gctcgacggc ggtacgacgc tggaggcggc ggaggcgcag
    19561 gtgcttgcgt acatcaagca gcatgtgccg gagccgggga aggcgccgct gtgcggcaat
    19621 tccgtcggca ccgaccgtgg cttcctgctg cgcgacatgc cgacgctgga gagctacctc
    19681 cactaccgga tcgtcgatgt ctcgtccgtg aaggaactgg cccggcgctg gttcccgcgg
    19741 gcctacttca acagtccgga caaaaacggc aaccaccggg cgctggcgga catccgtgaa
    19801 tccatcgcgg aactgcgcta ctaccgggag gcggtcttcg tgccgcagcc cggtcccgac
    19861 tcggacaccg cgaaggccat cgccgccaag cacgtccttc ctgctgagcc gcagtccacg
    19921 ccgtagcaag ccacagggcg cgtgtcgtgc gggtgctcac ggggccaccg tgacccgcac
    19981 gacacgccct cgggcccggg acgcgaaacc tgggcgcgag cacccctccg gaccctgtac
    20041 actttttctc agccggtggg gaaaaagaac cacacagcac cggtcatggt gggtatagct
    20101 cagctggtag agcacctggt tgtggtccag gatgtcgcgg gttcaagtcc cgttactcac
    20161 cccacttcaa ggcccccgac ctcaggtcgg gggccttggc gtttgccggc gtccggccgg
    20221 ccgcccatat aaggggacag aggccggggc ccggagccgg ggccgatgat cacagtcggg
    20281 tgctgtgccg aggggtcgcg gtgatcttca cgggattgcc gagggtgccg ttgacctcac
    20341 agcgggcgat cgcagacatg acaggtcccg gggtgggccg cgacacccgg tcgggacttc
    20401 cgttttccgt cggctgaggc gctgacgtcg tggacgggga gcccgtaccg gagatcccga
    20461 ggtggcgtcc tccgtgacgg gcggaccgcc gccggagatc ccttcgccgt accccggtct
    20521 ccttccgacc ggccgtaggg gcggtgcggg ctgagggcgg gcggtgggaa aggacggcgg
    20581 ggcgcagcgg gtggggggag cccgctgcgc cccggcctgg gggacggacg gtccgtgggg
    20641 gcggaccgcc ggtgggggtc agcccttgta cgcgccgaag gccctggtga agtccagcgg
    20701 cttctgctcg atggaactac aggtcggctg cgcggagttg ccggtgccgc cggggcaggc
    20761 ccggtcccgg gtcgaggacc acatcgacag ccaggccagg tgcttggtcc gggcgaactt
    20821 caccagctcg gtggcgtcgt cgcggcggaa gacctcgttc tggacgtcgt tgacgccgat
    20881 catcggggtc acggccacgg tcttccaggc ggccgcgtcg ctcaggccga gggccttctt
    20941 gagctggccc tgggtggcgg tggcggcctg ggtggcgtag gtgcccatgt cgccgctgta
    21001 ggcagggccg tagtccatcg ccatgatgtt gacggcggag atcttgacgc cgttcttctt
    21061 gg
//
