LOCUS       NZ_BBNO01000003        25417 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000003
VERSION     NZ_BBNO01000003.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 944465)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 303876
            Orig. end                         :: 329293
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25417
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /product="terpene"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25417
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="neighbouring"
                     /product="RiPP-like"
                     /product="terpene"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10228
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5228](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5228
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            55..963
                     /locus_tag="TU31_RS10270"
                     /old_locus_tag="TPA0598_03_02180"
     CDS             55..963
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091736.1"
                     /locus_tag="TU31_RS10270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02180"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_042152478.1"
                     /transl_table=11
                     /translation="MIEARRLHILRAVADHRTVTAAAAALYLTPSAVSQQLAALEQETG
                     HRLVERSARGVRLTAAGDILLTHANAVLAQLERAESELAAYGSGEAGTVTVAAFATGIG
                     LVVAPALTALARTAPGIRVHVQDAEGDASLLMVLDRQVDVAVAVEYRGAPGADDPRLTR
                     VPLYAEPFDAVLPPGHRLADTDRLAVADLAGDPWIGPYPGNPCHDVVVLACEYAGFQPR
                     LEHTSDDFRAVVALASAAAGVALVPRSALRDMDLTGVVVRPVDDVAPTRRVFAAVRRGA
                     EEHPLFRPVLAALREAAASQG"
     misc_feature    74..90
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            1109..2467
                     /locus_tag="TU31_RS10275"
                     /old_locus_tag="TPA0598_03_02190"
     CDS             1109..2467
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091737.1"
                     /locus_tag="TU31_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02190"
                     /product="chloride channel protein"
                     /protein_id="WP_042152481.1"
                     /transl_table=11
                     /translation="MSVGPAGPVGGAPTTAPQDPYALVRTRGYLKLLLVAGAIGVPVCA
                     VAFGFLALVHELEPLIYQDLPRALGFAGPPLWWPVPMLLVAGLLVGLTVRYLPGGGGHE
                     PADGLALSGAPPLSALPGVFLAALASLSFGVVLGPEAPLIALGGGLAAGAVRLLNRNMP
                     AQAAAAVGAAGSFAAISALLGSPLLGAFLLMEVSGLGGPMLGIVLLPGLLASGLGALIF
                     TGLGDWTGLGTYSLALHDIPRAAGPTIPEFGWALVIGLAAGFAATGVRRLARFLKGHVV
                     RHRVPATIVMGLVVGALATAFAAATGKPASEMLYSGQSALGSLFRDSAGYTVGALLLLI
                     LCKGLAYCASLSAFRGGPIFPALFLGAAGGVVLSHLPGLSLTAAFAMGVGAMCVAMLRL
                     PMTSVLLATLLLGKSGLTVMPLVIVAVVVAYVVALRLTPATVPDLPSAAPHPA"
     gene            complement(2491..3159)
                     /locus_tag="TU31_RS10280"
                     /old_locus_tag="TPA0598_03_02200"
     CDS             complement(2491..3159)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091738.1"
                     /locus_tag="TU31_RS10280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02200"
                     /product="SUMF1/EgtB/PvdO family nonheme iron enzyme"
                     /protein_id="WP_042152483.1"
                     /transl_table=11
                     /translation="MDTRTEYEMVAVPPGRVTLSDRRTRRSWPVELAPYRLAPCPVTQE
                     RYAQVTGERPSSAQGDRLPVEGVSWWDAVRFCNALSAQEGLAPAYRLDPDAERIEWDSS
                     AEGYRLPTEAEWEHACRAGTTAARYGRLDDIAWHRGNSHERIHEVGGRQPNAWGLSDML
                     GNVWEWCWDVYDAEVYGSYRVLRGGGWFDERWSCRASVRRRSHPTFRIDDVGFRIARSL
                     "
     gene            complement(3203..4234)
                     /locus_tag="TU31_RS10285"
                     /old_locus_tag="TPA0598_03_02210"
     CDS             complement(3203..4234)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091739.1"
                     /locus_tag="TU31_RS10285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02210"
                     /product="PHP domain-containing protein"
                     /protein_id="WP_107070662.1"
                     /transl_table=11
                     /translation="MEPVEALERIAFLLERQGAVTYRVQAFRTAATVIGALSADELRTR
                     ARSGSLARLKGLGPKTTRVIEEALAGARPEYLTHLEEEAGGPLVEGAQGQRLRQALRGD
                     CHLHSDWSDGGSPVETMARAARDLGHSWCVLTDHSPRLTVARGLTAERLRQQLSLVAEV
                     NERLAPFRLLTGIECDILDDGSLDQEPELLEQLDVVVASVHSKLRMDKGPMTRRLLAAV
                     RNPLVDVLGHCTGRQITGRPRPESQFDAEAVFAACAEHHTAVEINCRPDRFDPPRRLLR
                     LALETGTLFSIDSDAHAPGQLDWQIYGCARAEECGVPPERVINTWTERQLATWTRTGRT
                     PHR"
     cand_cluster    4452..25417
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4452..25417
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[14451:15417](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14452..15417
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     misc_feature    complement(4509..4526)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.87"
                     /tool="antismash"
     misc_feature    4584..4600
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.17"
                     /tool="antismash"
     gene            5001..5228
                     /locus_tag="TU31_RS10290"
                     /old_locus_tag="TPA0598_03_02220"
     CDS             5001..5228
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091740.1"
                     /locus_tag="TU31_RS10290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02220"
                     /product="hypothetical protein"
                     /protein_id="WP_042152485.1"
                     /sec_met_domain="strepbact (E-value: 6.4e-32, bitscore:
                     105.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVQTQEISDSDLDNVSGGLVGGVVGTATSTVDSIAPVSGA
                     VGTATGLVDGVAGTDTAGVVGTASGLVAGL"
     misc_feature    complement(5269..5281)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            5407..6213
                     /locus_tag="TU31_RS10295"
                     /old_locus_tag="TPA0598_03_02230"
     CDS             5407..6213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="TU31_RS10295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02230"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_042152488.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEEIDLPVRFARPQGWLVLTVTVLFVIAASAW
                     AVTGTVSSTLNAPGILTHGQGSYVLQSPVSGQVTAVLEEEGKRVAAHTPVLRVRTAQGT
                     TVVRTLAAGRLTTMVATIGSVVTTGADVASVERIAQADDPLTATLYVPAESGATVPVGA
                     SVDLTVQSVPTQQYGVLRGRVKAVGRTAQSRQRISTFLGSSQLGEEFSQHGQPVAVLVQ
                     LDAAPHTKSGYAWSTSDGPPYAVDSMTPASGAVHLAAQHPIDWLLP"
     misc_feature    complement(5430..5442)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            6210..8495
                     /locus_tag="TU31_RS10300"
                     /old_locus_tag="TPA0598_03_02240"
     CDS             6210..8495
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091742.1"
                     /locus_tag="TU31_RS10300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02240"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_042152492.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.2e-39, bitscore:
                     127.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHDSAAPQQQLPPPVRGRRRSEPAPGARRTRRAAPAPKPKKT
                     KTVRTPTVLQMEAVECGAASLAMVLAHYGRHVPLEELRIACGVSRDGSRASNLLKAARS
                     YGLQAKGMQMEPAALAEVQAPAILFWEFNHYVVYDGTGRRMGRRGVHINDPDKGRRFVA
                     TEDFDTSFTGVALVLEPGESFRKGGRKPGVLGAVPARMRGTTGTLLAALLASLLLVAVG
                     AAVPALSRTYIDMFLIGNQTSLLGPLFASMAAMVALTAVLTGLQQANLLRGRIISSTLT
                     SARFLRHLLRLPVTFFAQRSPADLVQRLQSNDAVAETLARDLAAAGVDGIVVVLYAFLL
                     WTYDPQLTVIGVGIALLNVVAMRIVIRLRATHTQKLRADTARLTNTSYTGLQLIETMKA
                     TGGENGYFRRWAGQHATTLEEQQRLGVPSAALAVVAPTLATLNSAMILWIGGLRAVEGH
                     ISIGLLVAFQALVTRFTAPITRLNGVAGRIQDFAADVARLKDVESFPVDTLYSRPEPEA
                     DTRRLKGHVTLEDITFGYSPLDKPLLTGFSLAVGPGRQVALVGGSGSGKSTVSRLISGL
                     YSPWEGTIRIDGQRLEDLSRSALAASVSFVDQDIFLFEGTVRDNVALWDPSIPDDAVIT
                     ALQDAALYDEVIAPRPDGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSA
                     LDARTEQIIMDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGVVVERGRHEDLVAAGGP
                     YAELVKEH"
     gene            8497..11376
                     /locus_tag="TU31_RS10305"
                     /old_locus_tag="TPA0598_03_02250"
     CDS             8497..11376
                     /GO_function="GO:0015440 - ABC-type peptide transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091743.1"
                     /locus_tag="TU31_RS10305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02250"
                     /product="NHLP bacteriocin export ABC transporter
                     permease/ATPase subunit"
                     /protein_id="WP_042152495.1"
                     /transl_table=11
                     /translation="MSVPPSAVVGPGDTDAVTYALGGLGTPVDCTGLRSVPLEGPHVLW
                     LVTGGSLDLFAVDAAQEGHWHFLGRLEAGTLLLGPVAGPQHTLLGRPSQDCLLRRIPLR
                     ELPRYEYGEYGDTGAFPQYGAQGYGNDPAYGGQGEAPSALEHAFALGTARSLGVLFEAP
                     LDGRPGDEAVADDDILWMPVPPGSVQYGASYGADAAGDLLVDPELWQQMVNQQYRLLSA
                     VDRWIEQLERAHEDRTAAGIKAGETVRERADQALVASIGRAGRGGTTTDRTSDDTTFAV
                     CRTVAEAAGITLTEPPKGGAVNDRITPVERIAVSSRIRTRAVRLQGSWWRTNTGPLVGH
                     RAKSGAPVALLWRRGRYEAVNPVSGLRMRLGKDNADELEPRAVMFYRPLPERPMSLWRL
                     MLFSLRGTRMDVRNLALSGLVTVGLGALVPIATGKVLGEYVPSADKSLIVQVSLAVMIT
                     SVVSAAFMLLQNLTVLRMEGRIESTLQPAVWDRLLRLPTKFFTERSTGELASAAMGISA
                     IRRVLSGLGPVAVQSSTIGAMNLVLLLVYSVPLALAAIAMLLVIGAVFLAMGLWELRWQ
                     RRLVKLGNKLNNQAFQTLRGLPKLRVAAAESFAYAAWAREFARSRELQQKAGRIKNLTT
                     VLNAVYLPVCSLTLFILLAGPARGTMSAASFLTFNTSVTMLLTAVTQITGAFVSAAAAL
                     PMFEQIKPVLDEKPEVRGASAQPGTLSGGIEAKKLSFRYTDDGPLVLDDVSLRVEPGEF
                     VAVVGPSGCGKSTLLRLLIGFDKPSSGSVLYDGQDLAALDQAAVRRQCGVVLQNAQPLT
                     GSILDCICGAEAFTQEEAWAAAEMAGLAEDIKRMPMGLHTMISGGGAISGGQRQRLMIA
                     QALVRRPRILFFDEATSALDNETQRVVSDSTRKLSASRLVIAHRLSTVMDADRVIVMAE
                     GRIVEQGPPAELLADTGGRLHDLVRRQLT"
     gene            11476..11934
                     /locus_tag="TU31_RS10310"
                     /old_locus_tag="TPA0598_03_02260"
     CDS             11476..11934
                     /GO_function="GO:0030551 - cyclic nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091744.1"
                     /locus_tag="TU31_RS10310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02260"
                     /product="cyclic nucleotide-binding domain-containing
                     protein"
                     /protein_id="WP_042152498.1"
                     /transl_table=11
                     /translation="MTMIENMLDELPPDRRRQLTDIAVEVSLPRATRLFEEGRRADRFW
                     IIRSGQVVLDQRVPGRRAAVVETLGRGELLGWSWLFPPYLWHLGAETVGPVEAVEFDAR
                     AIRELCESDPVLGRAMYRYVAKTVADRLHGTRTRLLDLYGPQGSGLDP"
     misc_feature    11486..11501
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(11487..11500)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.83"
                     /tool="antismash"
     gene            complement(<11976..>12065)
                     /locus_tag="TU31_RS39365"
                     /pseudo=""
     CDS             complement(<11976..12065)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014818415.1"
                     /locus_tag="TU31_RS39365"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="deaminase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDPATVPEQAREAAQGTDVRLGGGATTIRQ"
     gene            12323..12940
                     /locus_tag="TU31_RS10315"
                     /old_locus_tag="TPA0598_03_02270"
     CDS             12323..12940
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS10315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_03_02270"
                     /product="hypothetical protein"
                     /protein_id="WP_158894343.1"
                     /transl_table=11
                     /translation="MWWPRRHGPARQAKTPQPTRHRPPSSPWTSLREQLAVFFATWSVT
                     RLVHRDLGLSGVRDMQGLVDAVAVRRNKPITITEVPLPQQVSGFCARGNDRDFIVVDST
                     ANELTRLHVSLHELFHLWEEHPAEDGSAGQLMTEETVRQLLPGLKTGPVLKVLNRSHYD
                     SAHERRAEAFATVMLQRHLELRRDQRTNGFLSSALSHRRSGV"
     gene            12933..14222
                     /locus_tag="TU31_RS10320"
                     /old_locus_tag="TPA0598_03_02280"
     CDS             12933..14222
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519996.1"
                     /locus_tag="TU31_RS10320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02280"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_042152501.1"
                     /transl_table=11
                     /translation="MSESASNVVYLVIAVIDFVIAGWKCLALLRDPTPTLSLITVNFVA
                     SGLVFAMAAPAGYRMLGELTGVPSFATLPVYIGILTCFSLLHLLTMLWDPRLRQSPAVL
                     RRRVTVWSAAYLAAPAVMVVAFCSADLSGPTDPLKFNTNFAGDPLIQVFLAVFLTTLAC
                     GTLNTYRRCRKLNPADPRFRHALRSFGTAMLFVFGYVVCSVPAITLAALGNHALDTVGV
                     LGSTFGSIGALITSYGLSGAAVGAWLRERRDIKALQPLWDLVVEGVDEDLAFSVDSARS
                     HRLAWNVGFNLHRRVIEILDGMRALRPWVSPLPAAAVYAAQEQEASRGTADGRPLSEQD
                     LQAAATAAALRDAAQRLQAARLEAAAQGHAGHPQPPEGPQVALPGEDTPASDERQRLLR
                     VAQALTAPLVTTALQVVRVQRSAAEVPEGQ"
     gene            14452..15417
                     /locus_tag="TU31_RS10325"
                     /old_locus_tag="TPA0598_03_02290"
     CDS             14452..15417
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092344.1"
                     /locus_tag="TU31_RS10325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02290"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_042152505.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.5e-29, bitscore:
                     98.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 5.3e-14,
                     bitscore: 47.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATWPKTLDQAGITDPALRRDYSEQRQLVAHYARAEYTAVRLLLP
                     APLVPDVIAATAFMHHSDNLIDQGPAEERIAALADWESRVHAALKSGEADQPVLRTLLD
                     TLARQPQLRQYVEDFLAGAPLEVQTAGFATERDLQHYIDGYSLPAFLLIACLLGDGAPT
                     APYVAACRTFIEASQRLDFLNDLAEDLAGGRLGIPEELLTRHGLTRTGLTGEDGAAADG
                     LRPLLGDQVRQIRAGLSASYGLVDLVPARNRPFVRALVSIQGLTLRAAARKGTTLLDGS
                     ARPQVAAALRVLAREYAAARRGRDTRPAASVSGPTAGKAV"
     gene            complement(15460..16191)
                     /locus_tag="TU31_RS35850"
                     /old_locus_tag="TPA0598_03_02300"
     CDS             complement(15460..16191)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS35850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_03_02300"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_158894346.1"
                     /transl_table=11
                     /translation="MDASDMHPADGLRAVVAAIDELLRDLDLGRDVIDIDHLSHRTGLP
                     VPRVQALLDDTGEESETVQDSFQDRLVFLRETRRKPDGKTYTLDEIGAGAGISHGQVGY
                     LLNGKRKSPGLDVTRKLEKFFEVEPGFFTATERQALYRALQSTHEQLTHLALLRGKGIN
                     RLAMRSGTSGDSRIDRELRDALSEVLSRPEGEDPEVRELTDRMRSLPSKSRRRVFPLIQ
                     GLLGLARPEHEERPSPGRHNG"
     misc_feature    16327..16339
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    16350..16367
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     misc_feature    complement(16377..16390)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.99"
                     /tool="antismash"
     gene            complement(16570..17814)
                     /locus_tag="TU31_RS10335"
                     /old_locus_tag="TPA0598_03_02320"
     CDS             complement(16570..17814)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150779.1"
                     /locus_tag="TU31_RS10335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02320"
                     /product="MFS transporter"
                     /protein_id="WP_042152508.1"
                     /transl_table=11
                     /translation="MGGRRSLGRQFGWLWAAYGVSTFGTRLAFDAFPLLAVLVLHTGPA
                     AVSLLAAAGPAVGAVVAVPLGPWVEFRRKRPVMIAMDLARCAALLTVPVAFALGLLSFV
                     QLLVVSVVVTAADITFNAAGGACLKALVRPADLLVANSRFESTNWTATVLGPPLGGAAI
                     GLFGPVLTVLADAVSYLLSAVGIRAIGGKEPRPVRTGAPRLHAGDLLEGWRYLLAHPAL
                     RPLFFNTVLVNGLIMATSPLLAVLLLGRLGFAPWQYGLAFAVPCVGGLIGARLARRLVA
                     RFGQHKVLFTAGTLRACWSLGLIFVRPGTAGLVLVMVVELGLIACMGVFNPVFATYRLD
                     RTEPDRVTRTLSAWSVTSKATTAALTGMWGLLAALIGPRSAIAVAGLLMLVTPLLLPRH
                     EHAPQHEREVAGSHL"
     misc_feature    17819..17833
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            17953..18882
                     /locus_tag="TU31_RS10340"
                     /old_locus_tag="TPA0598_03_02330"
     CDS             17953..18882
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020397757.1"
                     /locus_tag="TU31_RS10340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02330"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_042152513.1"
                     /transl_table=11
                     /translation="MDLTAVRTVVAVADAGQFQVAATTLSITQQAVSKRIAALEKDLGV
                     RLFTRTARGARLTIDGQAFLPHARELLRAAERAAASVRPGSRALRIDVIGRRLCPAGLL
                     RDFHRAHPDTELDVVTLFDADAAFAAVRSGTIDASFRAVTLPARRLPDGVEAAWVFDEP
                     IQLLTGPAHPFATARTVTPAQLAGHRIWMPGIVTGTEWAAYYEDLATEFGLTIEVTGPD
                     FGTEPLLDTIADSAALATFVGENTRLVWPADQDLRRVPVHDPTPVYPHSLIWRTDNPHP
                     ALTTLRTYLGSTRPADRADGAWTPRWAR"
     misc_feature    18898..18910
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            <19109..19267
                     /locus_tag="TU31_RS37935"
                     /pseudo=""
     CDS             <19109..19267
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606586.1"
                     /locus_tag="TU31_RS37935"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GRVVASGTPRKVLTPQLPAEVFGVRAAVTGHPLTGDPLIAFDHRE
                     PLPADGG"
     gene            complement(19284..20237)
                     /locus_tag="TU31_RS10350"
                     /old_locus_tag="TPA0598_03_02350"
     CDS             complement(19284..20237)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DIT1_PvcA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003979694.1"
                     /locus_tag="TU31_RS10350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02350"
                     /product="L-tyrosine/L-tryptophan isonitrile synthase
                     family protein"
                     /protein_id="WP_245698484.1"
                     /sec_met_domain="DIT1_PvcA (E-value: 3e-75, bitscore:
                     248.8, seeds: 112, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTRPAPPRPVAPSDIRERCAEVLAALLPYRRTLDTAHGEVPDAF
                     PAHLRRLAGPVAAGEPIIFTLPGFPCKSPNPAKVLGHLPDEGERLALRFLDALCARIAA
                     HHPPGARVVICSDGHVFSDLIQVPDRDIDAYADALRTLIHDEGLTRLDVFDLRDVYGQR
                     LSHDAKRSLVHQRYAPDLETLRSLTRTDEPTRRLYQGITRFLFEDSVAFAGTRSALQRN
                     CRRRAYGVMQRSRAWGELIAAHHPEAFRLSIHPQPRDSAKFGIRLLEAPDVWLTPWHSC
                     VLEHPDGRRELLHRTEAERLGRLVYREGRPSHFMAG"
     misc_feature    complement(19998..20000)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20231..21502)
                     /locus_tag="TU31_RS10355"
                     /old_locus_tag="TPA0598_03_02360"
     CDS             complement(20231..21502)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606588.1"
                     /locus_tag="TU31_RS10355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02360"
                     /product="cytochrome P450"
                     /protein_id="WP_245698485.1"
                     /sec_met_domain="p450 (E-value: 6.1e-18, bitscore: 60.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPSSEPVELYGPEYKRDPYPLYAELRERGPVHRVRFPSGVCAWL
                     VTGYEAAHRALTDPRLGKHHSRGNAAWRARASIMPEPQHSQLQVHLLHQDPPRHTALRR
                     LITDAFAPQRVEALRPRFQAMADALLDGLPDSGGKADLVEVFAARFPFQVLAEVIGLPP
                     EFADRFDRDWGKVVQPVGPEDPGRPAYEARLRGLQQYIADLVRHKRAERGEDLLSRLVA
                     ARDADRIGQEELDSMVFQLLVAGQEPVTHQLTTALVTLLRHPTQLATLAGRPELLPPAV
                     EELLRHDSAFELTTWRFFAEDTELYGTRIPAGDSVIVSLSAANRDDRQFPDADALHFDR
                     TPNPHLAFGHGIHFCPGAALARIELQVALGTLLRRLPDLRLAVPEDELEWTPAVLARGV
                     GRLPVAYGGCPYAGSGANGPDAAC"
     gene            21759..22040
                     /locus_tag="TU31_RS10360"
                     /old_locus_tag="TPA0598_03_02370"
     CDS             21759..22040
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS10360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_03_02370"
                     /product="hypothetical protein"
                     /protein_id="WP_042152524.1"
                     /transl_table=11
                     /translation="MSSSSADRSRPPLRQAVTRLLPARSVIGFLALLVVLGMLSYAAGT
                     AVGPVAPGLHPAGGTRTGESTPTDHGDMGGMHGMGAPAPRPVPVGAPR"
     gene            22037..24439
                     /locus_tag="TU31_RS10365"
                     /old_locus_tag="TPA0598_03_02380"
     CDS             22037..24439
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606590.1"
                     /locus_tag="TU31_RS10365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02380"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_078885679.1"
                     /transl_table=11
                     /translation="MTPDPRPVTPSPDLAPAPVNSTTLTIGGMTCAACVGRVEKKLGRL
                     DGVAASVNLATGRAMVSHPAAVSVTDLISTVEAAGFTARLREPAPEPAPEDGQPPTGRQ
                     DGQDPSDAPETAGPQDPADDGARAEWHRLLVVALLSLPVLVLSMVPAWQFRNWQWLCFV
                     LAAPVAVWGAATFHTRALRGLRHGAATMDTLVSLGVAASFLWSAYALFLGGAGAPGMTM
                     PFSLLPTAGDGTAHVYLEAAVGVPLFVLAGRRMEARARRGTGAALRALAELAAKDVAVR
                     TPEGERRIPVSRLLVGDHFLVRPGERVATDGTVVEGSSALDLSLISGESRPVEVGPGAA
                     AVGGAVNSGGLLEVRADAVGADTQLARITRLVEDAQTGKTKVQRLADAVAAVFVPAVLT
                     VAVSVLGFWLGAGAEPQAAITAAVAVLVVACPCALGLATPTALLAATGRGAQLGILVRG
                     PEALERLRRIDTVVLDKTGTLTTGRMSVTALTPRTGGLDAAAALRLAATVEQGSEHPLA
                     RAVTAYADEQRPDQPLPPVADFSATPGHGVRGTADGRRVEVTRPGDVTGLPAPLPDAVH
                     TAETAGHTAVLVTVDGTPEAVLAIGDALRPDSYRAVDRLRRLGLRPVLATGDRAATARA
                     VAGHLAITEIHAEVRPEDKAALVTTLKEQGGRVAVVGDGVNDAAALALADLGIAMGSGT
                     DAAIGAADVTLVREDLQAIADAVHLARRTLGTIRGNLVWAFGYNLVTLPLAAVGLLSPM
                     PAAAAMSASSLLVVGNSLRLRAWRPGGTGTSARRPHRPRAQARWETR"
     gene            24436..24909
                     /locus_tag="TU31_RS10370"
                     /old_locus_tag="TPA0598_03_02390"
     CDS             24436..24909
                     /GO_function="GO:0016531 - copper chaperone activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540985.1"
                     /locus_tag="TU31_RS10370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_03_02390"
                     /product="copper chaperone PCu(A)C"
                     /protein_id="WP_042152526.1"
                     /transl_table=11
                     /translation="MKRLPLSAVAVPLFTCLVTLNVLALWTATGNAGTPAKLSVPEGRV
                     LIAGGSEATAAFFTIRNTGGADDVLTGVTGPTGHRAMLSRTVDIGNNARKMAMVRTVTV
                     PAGAALRMTPTGLDVMVSPPPRLAPGDRLTFTLHFRHSPPQTVRARAVRPGDG"
     misc_feature    25322..25336
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.71"
                     /tool="antismash"
ORIGIN
        1 ggccgccctc gggggctgac accgcccgcg ggccgctcct gcgagactgg aagcatgatc
       61 gaagcacgac ggctgcacat cctccgtgcg gtggccgacc accgcacggt caccgccgcg
      121 gccgccgcgc tctatctcac gccctcggcg gtctcccagc agctggccgc cctggaacag
      181 gagaccggcc accgtctggt ggagcgcagc gcccgcggcg tccggctgac cgccgcgggc
      241 gacatcctgc tcacccacgc caacgccgtc ctggcacagc tggagcgcgc cgagtcggag
      301 ctcgccgcct acggctcggg cgaggcgggc acggtgaccg tcgcggcctt cgccaccggc
      361 atcggcctgg tcgtcgcgcc cgcgctcacc gcactcgccc gcaccgcccc cggcatccgg
      421 gtccatgtcc aggacgccga gggcgacgcc agcctgctga tggtcctcga ccggcaggtc
      481 gatgtggcgg tggccgtcga ataccggggc gcaccgggcg ccgacgaccc acggctgacc
      541 cgggtcccgc tctacgccga gccgttcgac gcggtcctgc cgcccggcca ccgcctcgcc
      601 gacacggacc ggctggcggt ggccgatctc gccggcgacc cctggatcgg cccctacccc
      661 ggcaacccct gccatgacgt ggtggtcctg gcctgcgaat acgccggttt ccagccgcgc
      721 ctggagcaca cctccgacga cttccgcgcc gtcgtcgcgc ttgcctcggc cgcggcgggt
      781 gtggccctcg tcccccgctc ggcgctgcgc gacatggacc tcacgggggt ggtggtccgc
      841 cccgtcgacg atgtggcccc cacccgccgg gtcttcgccg cggtacgccg gggagccgag
      901 gagcacccgc tgttccgccc ggtgctcgcc gccctccggg aggcggcggc ctcgcagggg
      961 tgaggcaact gccgcgacgg agggccggat ccgccgtgcc ccgcccggcc gcgcccgagg
     1021 tgccggcccg gaccggccat ggcaggctca tcaccgcggc ggcccgggcg ggcgccgggg
     1081 cagccccggt tccgaggagg cgaggcgcat gtcggtcggc ccggccggcc cggtgggcgg
     1141 agcaccgacc accgcgccgc aggaccccta tgccctggtg cgcacgcgcg gatatctcaa
     1201 gcttctgctg gtggcgggcg cgatcggcgt tccggtctgc gccgtcgcat tcggctttct
     1261 cgcactggtc cacgagctgg aaccgctgat ctaccaggac ctgcctcggg cgctcggctt
     1321 cgccggcccg cccctctggt ggccggtccc gatgctgctg gtcgccggtc tcctggtcgg
     1381 gctgaccgtc cgttacctcc ccggcggcgg gggccatgag ccggctgacg ggctggcgct
     1441 cagtggtgcg cccccgctct ccgcgctccc cggtgtgttc ctggcggccc tggcctccct
     1501 cagcttcggc gtggtgctcg gccccgaggc accgctcatc gccctcggcg gcggtctggc
     1561 cgcgggcgcc gtacggctgc tgaaccggaa catgccggcc caggccgccg ccgcggtggg
     1621 cgcggccggc agcttcgcgg cgatcagcgc cctgctcggt tccccgctgc tgggcgcgtt
     1681 cctgctgatg gaggtgtcgg ggctgggcgg cccgatgctg gggatcgtgc tgctgcccgg
     1741 tctgctggcg tccggcctgg gcgcactgat cttcaccggg ctgggggact ggaccgggct
     1801 cggcacctac tcgctcgcgc tgcacgacat ccccagggcc gccgggccga cgattccgga
     1861 gttcggctgg gccctggtca tcgggctggc tgcaggcttc gccgcgaccg gcgtacggcg
     1921 cttggcgcgg ttcctcaagg gacatgtcgt ccggcaccgg gtaccggcca cgatcgtgat
     1981 gggcctcgtg gtgggcgcgc tggcgacggc gttcgccgcg gccaccggca agcccgcctc
     2041 cgagatgctc tattcgggcc agtcggcgct ggggtcgctg ttccgggaca gcgccggcta
     2101 cacggtgggc gcgctgctgc tcctcatcct gtgcaagggc ctggcgtact gcgcgtcgct
     2161 cagcgccttc cggggcggcc cgatcttccc cgcgctgttc ctcggtgcgg cgggcggtgt
     2221 cgtgctgtcc cacctgcccg gactgtcgct caccgcggcc ttcgcgatgg gggtgggcgc
     2281 gatgtgtgtg gccatgctcc ggctgccgat gacctcggtg ctgctggcaa cgctgctgct
     2341 gggcaagagc ggtctgacgg tgatgccgct ggtgatcgtc gccgtggtcg tcgcgtacgt
     2401 ggtggcgctg cgcctcactc cggccaccgt gccggacctg ccgtccgccg caccccaccc
     2461 cgcctgacgg cgaggccgga gccccgcccg tcagagggaa cgcgcgatac ggaagcccac
     2521 gtcatcgatc cggaaggtcg ggtggctgcg gcgccgtacc gaggcccggc agctccagcg
     2581 ctcgtcgaac catccgccgc cgcgcagcac ccggtagctg ccgtagacct cggcgtcgta
     2641 gacgtcccag caccactccc acacattgcc cagcatgtcg gacaggcccc atgcgttggg
     2701 ctgccggccg ccgacctcgt ggatccgttc gtgcgagttg ccgcggtgcc aggcgatgtc
     2761 gtcgagccgc ccgtaccgtg ccgccgtcgt gccggcccgg caggcgtgct cccactcggc
     2821 ctcggtcggc agccggtacc cctcggcgga gctgtcccat tcgatccgct cggcgtcggg
     2881 gtccaggcga tacgcgggtg ccaacccctc ctgcgcggac agggcgttgc agaaccggac
     2941 cgcgtcccac cacgagacgc cctcgacggg gagccggtcg ccctgcgcgc tgctcgggcg
     3001 ctcgccggtg acctgcgcat accgttcctg agtgaccggg cacggcgcga gccggtaggg
     3061 cgccagctcg accggccaac tgcgccgcgt ccgccggtcc gacagcgtca cccgccccgg
     3121 cgggacggcg accatctcgt actccgtgcg cgtgtccatg aggaggcgag cgtaccgccc
     3181 cgcgcggcga cggggagcgc gttcagcggt gcggggtccg gcccgtccgg gtccaggtgg
     3241 ccaactggcg ctccgtccag gtgttgatga cccgctccgg cgggacgccg cactcctcgg
     3301 cacgggcaca gccgtagatc tgccagtcca gttggcccgg tgcgtgggcg tcgctgtcga
     3361 tggagaacag ggtcccggtc tccagcgcca ggcggagcag ccggcgcggg ggatcgaagc
     3421 ggtcgggacg gcagttgatc tccaccgcgg tgtggtgctc ggcgcaggcc gcgaacaccg
     3481 cttcggcgtc gaactgcgat tccgggcgcg gtctgccggt gatctgccgc ccggtgcagt
     3541 gaccgagcac gtccaccagc ggattgcgga ccgcggccag cagccgccgg gtcatcggcc
     3601 ccttgtccat ccgcagtttg gagtgcaccg aggcgaccac cacatcgagc tgctccagca
     3661 gctccggctc ctggtcgagt gagccgtcgt cgaggatgtc gcactcgatc ccggtcagca
     3721 gccggaacgg tgccagccgc tcgttcacct ccgccaccag cgacaactgc tgccgcagcc
     3781 gctcggcggt cagtccgcgg gcgacggtga gcctggggga gtggtcggtc agcacacacc
     3841 aggagtggcc gaggtcgcgg gcggcccgcg ccatcgtctc gaccgggctg ccgccgtccg
     3901 accagtccga gtgcagatgg cagtcgccgc gcagcgcctg acggagccgc tgcccctggg
     3961 ccccctcgac cagcgggccg cccgcctcct cctcaaggtg cgtcagatac tccggccgcg
     4021 cgcccgcgag cgcctcctcg atcacccggg tggtcttggg gcccagccct ttgagccgcg
     4081 ccagcgagcc gctccgggca cgggtgcgca gctcgtcggc ggacagcgca ccgatcaccg
     4141 tcgcggccgt acggaacgcc tggacgcggt aggtcaccgc cccctgccgc tccagcagaa
     4201 aggcgatccg ctccagcgcc tccacgggct ccacgtacgg ctccttcccg gggcgcggcc
     4261 ccgcagcgtc gtttctcacg gtgccccacc cggtgggcgg ctgccaccgg gctgccggtg
     4321 cggggtgcca atcgcccatt accgacgggt ccgaaggcgc tccgttatgc ggttatgtcc
     4381 gttgtccggt tactcgatcc gttcctgatc ctttccgtgg aaatggcata tggatagcgc
     4441 cgataagtcc attccatacg ttcagcaccg ccgataagga ctgtgaactc cgggcgaatc
     4501 gggcgcactt aatgcccttg caacattcgg cgcggctgcg tcggaagggc gcgccggagg
     4561 cgtctgcccg tatcgcgccg aggtgccgta aaaattggcg gccttcaaag aatctgcaca
     4621 ccgaatgtgc agtcggcaca cgctcggccg ccccgtattc ccacgctgac ctgcggctca
     4681 gcggtttggt gacggaatgt ccagttcgcc gaacgggtgc ttgccgaggt ctcggaaaag
     4741 aaaccggagg agatgtgaag aagctgccac caagtcatgg acgggcgtgc acgtcaggta
     4801 tttcgacggg gcgatatcgc ccggatcagc ggctacccga ttagcagcac aacgcgcctg
     4861 catgctttga tccttcgcac tgcgggagtc accccccggt tcccgatttc gggaacccga
     4921 ctgccgctgc cgcgaccggg ccgacccacc ggacggttcg ggcgcgggtt tttcgagata
     4981 ttcatccgaa gggaatcatc atgaactcca ccccccaggt tcagacgcag gaaatctccg
     5041 acagcgacct ggacaacgtg tccggtggcc tcgtcggcgg cgtggtcggc accgccacca
     5101 gcaccgttga ctccatcgcc ccggtctcgg gcgccgtggg caccgccacc ggcctggtcg
     5161 acggtgtcgc cggcaccgac accgcgggcg tcgtcggcac cgcctcgggc ctggtcgccg
     5221 gtctctgagc ccttctgtgc cgctgagcgg cacagccggc tttgaacggt gacaacggca
     5281 ggtcggcgcc ccctccttgc cgatatgccg ggccggctgc cccggtccgc ccggactcca
     5341 tccgggcacc ggggcaccgg ccaccacccg tccgaaccag aacgttgcag ttgagggaag
     5401 agtgtcgtgc agttccgcca acaggccctt tccaaactgc aatcgcccga ggaaatcgat
     5461 cttccggtgc ggttcgcccg cccccagggc tggctcgtgc tgaccgtcac ggtcctcttc
     5521 gtgatcgccg cctccgcatg ggcggtgacc ggcaccgtgt cgtccaccct gaacgcaccc
     5581 ggcatcctca cccacggcca gggcagctac gtcctccaga gccccgtctc gggccaggtc
     5641 accgccgtac tcgaggaaga gggcaagcga gtggccgccc acacgcccgt cctgagggtc
     5701 cgtaccgccc agggcaccac cgtcgtccgt acgctcgccg ccggccggct gaccacgatg
     5761 gtcgccacca tcggctccgt cgtcacgacc ggggcggatg tggcctccgt ggaacgcatc
     5821 gcccaggccg acgaccccct gacggcgacg ctgtacgtac cggccgagag cggcgccacg
     5881 gtgcccgtcg gcgcatccgt cgacctcacc gtccagtccg tgccgaccca gcagtacggc
     5941 gtcctgcgcg gacgggtcaa agcggtcggc aggaccgcgc agtcccgcca gcggatcagc
     6001 actttcctgg gcagcagcca gctcggcgag gagttctcgc agcacggcca gcccgtcgcg
     6061 gtcctggtac aactcgacgc cgccccgcac accaaatccg gctacgcctg gtcgacctct
     6121 gacggcccgc cgtacgccgt cgactccatg acgccggcca gtggcgccgt ccacctggcc
     6181 gcgcagcacc cgatcgattg gctgctgccg tgaccgcccc acacgactcc gccgccccgc
     6241 agcagcagtt gccaccgccg gtccgcggcc gccgccgctc ggaacccgcg cccggcgccc
     6301 gccgcacccg ccgggccgcg cccgccccga agcccaagaa gacgaagacc gtccgcaccc
     6361 ccaccgtcct ccagatggag gccgtggagt gcggcgccgc ctcgctggcc atggtgctgg
     6421 cccactacgg acggcatgtg ccgctcgaag agctgcggat cgcctgcggt gtctcccgcg
     6481 acggctcgcg cgccagcaat ctgctcaagg ccgcccgcag ctacggactc caggccaagg
     6541 gcatgcagat ggaaccggcc gcgctcgccg aggtgcaggc gcccgccatc ctgttctggg
     6601 agttcaacca ctacgtcgtc tacgacggta cgggccgtcg catgggccgc cgcggcgtgc
     6661 acatcaatga ccctgacaag ggccggcgct tcgtggcgac ggaggacttc gacaccagct
     6721 tcaccggcgt cgccctggtc ctcgaacccg gcgaatcctt ccgcaagggc ggccgtaagc
     6781 ccggcgtcct cggcgccgtg cccgcccgga tgcgcggcac gaccggcacc ctgctggccg
     6841 cgctgctcgc cagcctgctg ctggtcgcgg tcggcgcggc ggtgcccgcg ctcagccgga
     6901 cgtatatcga catgttcctg atcggcaacc agacctcgct gctggggccg ctcttcgctt
     6961 cgatggccgc catggtcgcg ctgaccgccg tactgaccgg tctgcaacag gccaacctgc
     7021 tgcgcggccg catcatctcc tccaccctca ccagcgcccg cttcctgcgc catctgctca
     7081 gactcccggt caccttcttc gcccagcgca gcccggccga cctggtccag cggctgcagt
     7141 ccaacgacgc ggtggccgag acgctggccc gtgacctcgc cgccgcgggc gtggacggca
     7201 tcgtcgtcgt cctctacgcc ttcctgctgt ggacctacga cccccaactg accgtcatcg
     7261 gcgtgggaat cgcgctgctc aatgtcgtcg ccatgcggat cgtgatccgg ctgcgggcca
     7321 cccacaccca gaagctgcgc gccgataccg cgcggctgac caacacctcc tacaccggcc
     7381 tccagctcat cgagacgatg aaggccaccg gcggggagaa cggctacttc cgccgctggg
     7441 ccggccagca cgccaccacc ctggaggaac agcagcggct gggcgtgccg agcgccgcgc
     7501 tggccgtggt cgcccccacc ctcgccacgc tcaacagcgc gatgatcctg tggatcggcg
     7561 gactgcgggc ggtcgagggc catatctcca tcggtctgct cgtcgccttc caggccctgg
     7621 tcacccgatt caccgcgccc atcacccggc tcaacggagt ggcgggccgg atccaggact
     7681 tcgccgccga cgtggcccgc ctcaaggacg tcgagagctt ccccgtcgac accctctact
     7741 cgcgccccga gccggaggcc gacacccgcc ggctcaaggg ccatgtgacg ctggaggaca
     7801 tcaccttcgg atacagcccg ctggacaaac cgctgctgac cggcttctcc ctggccgtcg
     7861 gcccgggccg gcaggtcgct ctcgtcggcg gctccggcag cggcaagtcc accgtctccc
     7921 ggctgatctc cggcctctac agcccctggg aaggcaccat ccgcatcgac ggacagcggc
     7981 tggaggacct ctcccgcagt gcgctggccg cctccgtctc cttcgtcgac caggacatct
     8041 tccttttcga gggcacggtc cgcgacaacg tggcgctgtg ggacccgtcc atcccggacg
     8101 acgcggtgat caccgccctc caggacgccg cgctctacga cgaggtgatc gccccccggc
     8161 ccgacggcat ccacagccgg gtcgagcagg acggccgtaa cttctccggc gggcagcggc
     8221 agcggctgga gatcgcccgc gccctggtcc ggcgccccag catcctggtc ctcgacgagg
     8281 tcaccagcgc actggacgcc cggaccgaac agatcatcat ggacaacctg cggcggcgcg
     8341 gctgcgcctg cgtcgtcatc gcccaccggc tgagcacggt ccgcgacagc gacgagatcg
     8401 tcgtcctcga ccacggggtg gtcgtcgaac gcggccgcca cgaggacctg gtcgccgccg
     8461 ggggcccgta cgccgagctg gtcaaggagc actgacgtgt ccgtaccccc gtccgcggtc
     8521 gtgggaccgg gcgacaccga tgccgtcacc tatgcgctgg gcggcctcgg tacaccggtc
     8581 gactgcaccg ggctgcgcag cgttcccctg gagggcccgc atgtgctgtg gctcgtcacg
     8641 ggcggctcgc tggatctctt cgcggtcgac gccgcccagg aggggcactg gcacttcctc
     8701 ggccgcctcg aagcgggcac cctgctgctc ggcccggtcg cgggcccgca gcacaccctg
     8761 ctcggccggc cctcccagga ctgcctgctg cgccgtatcc cgctgcgcga gctgccccgc
     8821 tacgagtacg gggagtacgg cgacaccggg gcgtttccgc aatacggcgc gcagggctac
     8881 ggcaacgacc ccgcgtacgg cggccagggc gaggcgccct ccgcgctgga gcacgccttc
     8941 gcgctgggca ccgcccgcag cctgggcgtg ctgttcgagg caccgctcga cggccgcccc
     9001 ggcgacgagg cggtggccga cgacgacatc ctgtggatgc cggtcccgcc cggcagtgtg
     9061 cagtacggcg cctcctacgg cgcggacgcg gccggcgatc tgctggtgga ccccgagctg
     9121 tggcagcaga tggtcaatca gcagtaccgg ctgctgtccg ccgtcgaccg ctggatcgag
     9181 cagctggagc gcgcccacga ggaccgtacg gcggccggaa tcaaggcggg tgaaaccgtt
     9241 cgcgagcgcg ccgaccaggc gctggtggca tccatcggcc gggccgggcg gggcggtacg
     9301 acgacggacc ggaccagcga cgacaccacc ttcgcggtct gccgcacggt cgcggaggcg
     9361 gccggtatca cgctcaccga gccaccgaag ggcggcgccg tcaacgaccg gatcaccccg
     9421 gtcgaacgga tcgcggtcag ctcgcggatc cggacccgcg cggtccggct ccagggaagc
     9481 tggtggcgga ccaacaccgg ccccctggtg ggccatcgcg ccaagtccgg tgcgccggtg
     9541 gcgctgctgt ggcgccgcgg ccggtacgag gcggtcaacc cggtctccgg gctgcggatg
     9601 cgcctcggca aggacaacgc cgacgagctc gaaccgcgcg ccgtcatgtt ctaccgcccg
     9661 ctgccggagc ggcccatgag cctgtggcgg ctgatgctct tcagcctgcg cgggacccgg
     9721 atggacgtcc gtaatctggc cctcagcgga ctggtgaccg tcggcctcgg cgccctcgtc
     9781 cccatcgcga ccggcaaggt gctcggggag tacgtaccga gcgccgacaa gagcctgatc
     9841 gtgcaggtct ccctggccgt catgatcacc agcgtggtct ccgccgcctt catgctgctt
     9901 cagaacctca ccgtcctgcg gatggagggc cgcatcgaga gcaccctcca gccggccgtg
     9961 tgggaccggc tgctgcggct gccgacgaag ttcttcaccg aacgctccac cggcgagctg
    10021 gccagcgccg cgatgggcat cagcgccatc cgccgggtgc tgtccggcct cggcccggtg
    10081 gccgtgcagt ccagcacgat cggcgcgatg aacctggtgc tgctgctcgt ctacagcgtg
    10141 ccgctggcgc tggcggcgat cgccatgctg ctcgtcatcg gtgcggtgtt cctcgccatg
    10201 ggcctgtggg agctgcgctg gcagcgacgg ctggtcaagc tcggcaacaa gctcaacaac
    10261 caggcgttcc agaccctgcg cgggctgccc aaactgcggg tcgccgcggc cgagagcttc
    10321 gcgtacgcgg cctgggcccg ggagttcgcc cgctcccggg aactccagca gaaggccggc
    10381 cggatcaaga atctgaccac cgtcctcaac gcggtctatc tgccggtctg ctcgctcacc
    10441 ctcttcatcc tgctggccgg cccggcccgc ggcaccatgt cggccgcctc cttcctcacc
    10501 ttcaacacct cggtgaccat gctgctgacc gcggtcaccc agatcaccgg cgcgttcgtc
    10561 tcggccgccg ccgcgctgcc gatgttcgag cagatcaagc cggtgctgga cgagaagccg
    10621 gaagtgcgcg gggccagcgc ccagcccggc accctgtccg gcggcatcga ggccaagaag
    10681 ctctcgttcc gctacaccga cgacggcccg ctcgtcctcg acgatgtctc gctgcgggtc
    10741 gagccgggtg agttcgtggc cgtcgtcggc ccgagcggct gcggcaagtc gaccctgctg
    10801 cggctcctca tcggcttcga caagccgtcc tcgggcagtg tgctctacga cggccaggac
    10861 ctggccgccc tggaccaggc ggcggtgcgc cggcagtgcg gggtggtgct gcagaacgcc
    10921 cagccgctca ccggatcgat cctggactgc atatgcggcg ccgaggcctt cacccaggaa
    10981 gaggcctggg cggccgccga gatggcgggc ctggccgagg acatcaagcg gatgccgatg
    11041 ggcctgcaca ccatgatctc cggcggtggc gcgatctccg gcggccagcg gcagcgcctg
    11101 atgatcgccc aggcactggt ccgccgcccg cggatcctgt tcttcgacga ggccaccagc
    11161 gccctggaca acgagaccca gcgcgtggtc agtgacagca cccgcaagct cagcgccagc
    11221 cggctggtga tcgcccaccg gctgtccacg gtcatggacg ccgaccgtgt gatcgtgatg
    11281 gcggagggcc ggatcgttga gcaggggccc ccggccgaac tgctcgccga caccggtggc
    11341 cggctgcacg atctggtgcg gcgtcagctg acctgacagg gaccgggctg cggcccgccg
    11401 gtgcccggcg ggccgagcca ttcccccgat ccccgcaaag ctccgcatat cgtgcaggca
    11461 gcgagcggag gacgcatgac catgatcgaa aatatgctcg acgagttgcc gcccgaccgg
    11521 cgccgacagc tgaccgatat cgccgtcgag gtgtcgctgc cgcgcgccac ccggctcttc
    11581 gaggagggcc ggcgggcgga ccggttctgg atcatccgca gtggacaggt ggtgctcgac
    11641 cagcgcgtcc ccgggcgccg ggcggcggtg gtggaaaccc tcggccgtgg cgaactcctc
    11701 ggctggtcct ggctgttccc gccctacctg tggcacctgg gagcggagac cgtcggcccg
    11761 gtggaggccg tggagttcga cgccagggcg atccgtgagc tgtgcgaatc cgaccccgtc
    11821 ctcggccggg cgatgtaccg ctatgtggcc aagacggtgg ccgaccggct gcacggcacc
    11881 cgcacccggc tgctcgatct gtatgggccc cagggcagcg gcctcgaccc ctgagggctg
    11941 tcccgcattc cctggcgggc gcacgacgac ggctgctgcc ggatggtggt ggccccgccg
    12001 ccgagccgga cgtccgtgcc ctgcgcggcc tcccgcgcct gttcgggaac ggtggccggg
    12061 tcgccgccga gctcagcgct gtgtccgtgg cggtcaccgc accggggcgg gccgctcccg
    12121 gccccctccg cgcaaggccg cccaggagca ccgggtaact tttggcttgc gcagggcttc
    12181 cgccgccctc gtcccgggag gagggttccg tgcggccctg gcgcaccgac aatccccgac
    12241 ccaccgggct cgcagtcgtc ccggatcgcg taccgttcct tcctcacccc gagcgcagca
    12301 acagctgtag gagtatccgt tcatgtggtg gccccgtcgt catggtccag cgcggcaggc
    12361 gaaaacgccg cagcccaccc gccaccggcc gcccagctcc ccgtggacct cgctccggga
    12421 gcagttggcg gtcttcttcg cgacctggtc cgtcacccgg ctcgtccatc gcgacctcgg
    12481 gctgtccggt gtacgggaca tgcagggact ggtcgacgcg gtggccgtgc gacgcaacaa
    12541 gccgatcacg atcacggaag tgccgctccc gcagcaggtg tccgggttct gcgcccgggg
    12601 caacgaccgt gacttcatcg tggtggattc caccgcgaac gagctgaccc gcctgcacgt
    12661 cagcctgcac gagctgttcc acctgtggga ggagcacccg gccgaggacg gctccgccgg
    12721 ccagctcatg accgaggaga ccgtgcggca gctccttccc ggactcaaga cgggcccggt
    12781 gctgaaggtc ctcaaccgct cgcactacga cagcgcccat gagcggcggg cagaggcctt
    12841 cgccaccgtg atgctccagc gccatctgga actgcggcgc gatcagcgca ccaacgggtt
    12901 cctctcctcg gcgctctccc accggaggtc cggtgtctga gagcgcctcg aacgtcgtct
    12961 acctggtcat cgcggtcatc gacttcgtga tcgccgggtg gaagtgcctg gcactgctgc
    13021 gcgatcccac accgacgctg tccttgatca cggtgaactt cgtggcgtcc ggcctggtgt
    13081 tcgcgatggc cgcacccgcg gggtaccgga tgctggggga actcaccggc gtccccagct
    13141 tcgccaccct ccccgtctac atcggcatcc tgacctgctt ctccctcctc cacctgctca
    13201 cgatgctgtg ggatccccgg ctgcggcaga gcccggcggt gctgcgccgc cgggtcacgg
    13261 tgtggtccgc ggcgtatctc gcggcaccgg ccgtcatggt cgtcgcgttc tgctccgccg
    13321 atctgtccgg gccgacggac cctctcaagt tcaacaccaa cttcgcgggt gatccgctga
    13381 tccaggtatt cctggcggtc ttcctcacca ccttggcctg cggaaccctg aacacctacc
    13441 ggcggtgccg caagctgaac ccggcggacc cccggttccg gcacgcgctg cgctccttcg
    13501 gcaccgccat gctgttcgtc ttcggctatg tggtctgctc cgtcccggcc atcacgctgg
    13561 ccgccctcgg caaccacgcc ctggacacgg tcggggtgct cggctccacc ttcggctcga
    13621 tcggcgccct gatcaccagc tacggcctct ccggagccgc ggtgggtgca tggctgcgcg
    13681 aacgccggga catcaaggcc ctccagccgt tgtgggacct cgtcgtcgaa ggggtcgacg
    13741 aggacctcgc cttcagcgtg gacagcgcac ggagtcatcg cctggcatgg aacgtgggat
    13801 tcaacctgca ccgccgggtg atcgagatcc tcgacgggat gcgcgcgctg cgtccctggg
    13861 tgtcgcccct gcccgcggcc gccgtctacg ccgcgcagga acaagaggcg tcccggggca
    13921 ccgccgacgg ccggccgctc tcggagcagg acttgcaggc ggcggccacc gccgctgccc
    13981 tgcgggacgc ggcgcagcgc ctccaggccg cccggctgga ggcggcggca caggggcatg
    14041 ccggccatcc gcagccgcct gagggaccgc aggtggcgct gcccggcgag gacaccccgg
    14101 cctccgacga acgccaacgg ctgctgcgcg tcgcccaggc gctcaccgcc ccgctggtca
    14161 ccacggcgct ccaggtcgtg cgcgtacagc ggtccgccgc cgaggtgccc gaagggcagt
    14221 agtccgccac ggccgacgtg gccccgctcc cggccggccc ggcagtcccg accattcctc
    14281 ccgcccaggg cgccccggcc cggaagtggc aactcacctc gcggccgggc gacttggggg
    14341 agcgcccacg gcccggtgca ccccgtgtgc ggtgccggcg ccgggacgga tcggtcccct
    14401 cggccgcgat cacctaaggt gaaaccgcac tcgaggaaag gggcgctgac gatggccacg
    14461 tggccgaaga cgctcgacca ggcagggatc accgatcccg cactgcgtcg tgactacagc
    14521 gaacagcgtc agctggtggc gcactacgcc cgcgcggaat acacggccgt gcggctgctg
    14581 cttcccgcgc cgctggtgcc cgacgtcatc gccgcgaccg cgttcatgca ccacagcgac
    14641 aacctcatcg accagggacc ggccgaggag cgcatcgcgg cgctcgccga ctgggagagc
    14701 cgggtgcacg ccgccctcaa gagcggcgaa gccgaccagc ccgtgctgcg gacgctcctc
    14761 gacaccctcg ccaggcagcc tcaactccgg cagtacgtcg aagacttcct cgccggggcg
    14821 ccgctggagg tgcagacggc gggattcgcc acggagcgcg acctccagca ctacatcgac
    14881 ggctattcgc tgcccgcctt cctgctcatc gcctgcctgc tgggcgacgg agcgcccacg
    14941 gccccgtacg tcgccgcgtg ccggaccttc atcgaggcga gccagcggct ggacttcctg
    15001 aacgacctcg ccgaagacct ggccggcgga cgcctcggca tccccgaaga gctcctcacc
    15061 cgccacggcc tgacccgcac cggcctgacc ggcgaggacg gcgccgccgc tgacgggctg
    15121 cgcccgctgc tcggtgacca ggtccggcag atccgcgcgg gtctgtcggc gtcgtacggg
    15181 ctcgtggatc tggtacccgc ccgcaaccgg ccgttcgtcc gggccctcgt cagcatccag
    15241 ggcctcacgc tgcgcgcggc ggcacggaag gggaccacgc tgctcgacgg gtccgcccgg
    15301 ccgcaggtgg cggcggccct gcgggttctc gcccgggaat acgcggccgc gcgtcgtggc
    15361 cgtgacacga ggccagccgc cagcgtgagc gggccaacgg cgggcaaggc ggtctgatcc
    15421 cggagacgga ccgggcggac cggcgacgtc cggttccgtt cagccgttgt gccggcccgg
    15481 ggacggacgc tcctcgtgct cgggccgggc caggcccaac agcccctgga tcaggggaaa
    15541 gacccgcctt ctgctcttgg agggcagcga gcgcatacgg tccgtgagct cccgtacctc
    15601 gggatcctcg ccctcgggcc ggctcagaac ctcggacagt gcgtcccgga gttcccggtc
    15661 gatcctgctg tcgccgctgg tgccgctgcg catcgccagc cggttgatgc ccttgcccct
    15721 gagcagcgcg agatgggtca gctgttcatg cgtcgactgg agtgcccggt acagcgcctg
    15781 acgctcggtg gcggtgaaga agcccggctc gacctcgaag aacttctcca gtttccgggt
    15841 gacatccagc ccggggctct tccgcttgcc gttcaggagg tagccgacct ggccgtggga
    15901 gataccggct cccgcaccga tctcatcgag ggtgtacgtc ttcccgtcgg gcttgcggcg
    15961 ggtctcccgc aggaagacga ggcggtcctg gaaggagtcc tgcaccgtct cggattcctc
    16021 gccggtgtca tcgagcaacg cttgcacgcg ggggaccggg aggccggtcc ggtgcgagag
    16081 gtggtcgatg tcgatgacgt cgcgcccgag gtccaagtcc cggagaagct cgtcgatcgc
    16141 tgcgacgacg gctcgaagac catccgccgg gtgcatgtct gaggcatcca tggcgatggg
    16201 cggtctcctg gtcggtggac agacgggacg gcggcacgct cgcagccgct ccgaggttag
    16261 cggtagccag caccgtacgc catggacggc acaacaattg tgtcaagggg catctttcga
    16321 tggtccgtga agtcgtcacc agcgctcttg agttaaacga ttgttgacaa cgtgggtttg
    16381 gttgaaggat cctcaccaag gcgatgccgc tgaacgaccg gcgggcacgt tgcgcagggg
    16441 gccgctcaca tttcccgcac ctcgcaactg ccgcccttcc cggcgtgtgg tgccgggctc
    16501 cacaggggag agcccggcac cacaccgcct gttgaccgca gccgacgccc cggagggcga
    16561 ccgggccggt cagaggtgac tcccggccac ttcccgttcg tgctgcggcg cgtgctcgtg
    16621 ccgggggagc aggagcgggg tcaccagcat gaggagaccg gcgaccgcga tcgcgctgcg
    16681 gggaccgatg agggcggcca gcaggcccca catcccggtc agggccgcgg tggtggcctt
    16741 gctggtgacc gaccacgcgg acagggtgcg ggtcacccgg tccggttccg tccggtcgag
    16801 ccggtaggtg gcgaacaccg ggttgaacac gcccatgcag gcgatcaacc ccagctcgac
    16861 gaccatgacg agcaccagcc cggcggtgcc cgggcggacg aagatcagcc cgagcgacca
    16921 gcacgcccgc agcgtcccgg ccgtgaacag gaccttgtgc tgtccgaacc gcgcgacgag
    16981 ccggcgggcc agccgtgcgc cgatcagccc gccgacacag ggcaccgcga aggcgagacc
    17041 gtactgccag ggggcgaacc cgagccggcc gagcagaagg acggccagca gcggcgacgt
    17101 ggccatgatc aggccgttga ccaggaccgt gttgaagaac agcgggcgca gcgccgggtg
    17161 ggccaggagg tagcgccacc cttcgagcag atccccggcg tggagccgtg gggcaccggt
    17221 gcgtacgggc cggggctcct tgccgccgat cgcacggatt cccacggccg agagcagata
    17281 gctgaccgca tcggccagca cggtcagcac cggaccgaac agcccgatcg cggccccgcc
    17341 gagcgggggg ccgagcacgg tggcggtcca gttcgtggac tcgaaccggg agttcgcgac
    17401 gagcaggtcc gccggccgca ccagcgcctt cagacaggcg ccgccggccg cgttgaaggt
    17461 gatgtccgcg gccgtgacga cgaccgacac gaccaggagc tggacgaagc tgagcagacc
    17521 gagggcgaac gcgacgggca cggtcagcag cgccgcgcac cgtgccagat ccatcgcgat
    17581 catcaccggc cgcttgcggc ggaactccac ccacgggccg agcggcaccg ccaccaccgc
    17641 ccccaccgcc ggccccgcgg cggccagcag cgacaccgcc gccggcccgg tgtgcagcac
    17701 cagaaccgcg agcaacggaa acgcgtcgaa cgcgagccgg gtcccgaacg tactgacccc
    17761 gtacgccgcc cacagccacc cgaactgccg ccccagcgac cgtctgcccc ccacgcccac
    17821 cacttccctc gatctccgcc cgaacaaccc cacgttgacc gaatccatca aagccagcag
    17881 caagccaccc gatcaaacaa ccaacccacc cggcaggcca caaccacacg ttgtgtgaat
    17941 acactgccgg gcgtggatct caccgccgtg cgcaccgtcg tcgccgtcgc cgacgcggga
    18001 caattccagg tcgccgccac caccctctcg atcacccagc aggccgtctc caagcgcatc
    18061 gccgcgctgg agaaggacct cggtgtgcgg ctgttcaccc gtaccgcgcg cggcgcccgg
    18121 ctcaccatcg acgggcaggc gttcctgccg cacgcccgcg agctgctccg tgccgcggag
    18181 cgggcagcgg cttcggtccg gcccggcagc cgcgcgctgc gcatcgatgt gatcggccgg
    18241 cggctctgcc cggcgggtct gctgcgcgac ttccaccgcg cgcaccccga caccgaactc
    18301 gacgtggtga cactcttcga cgccgacgcg gccttcgccg cggtccgctc gggcacgatc
    18361 gacgcgtcct tccgcgcggt caccctgccc gcgcgccgac tccccgacgg cgtcgaggcc
    18421 gcctgggtct tcgacgagcc catccaactg ctcaccggcc cggcccatcc gttcgccacc
    18481 gcccgtacgg tcacccccgc gcagctcgcc ggacaccgga tctggatgcc cggcatcgtc
    18541 accggcacgg aatgggctgc ctactacgag gacctcgcca ccgagttcgg tctcaccatc
    18601 gaggtgaccg gccccgactt cggcaccgaa ccactcctcg acacgatcgc cgactccgcc
    18661 gcactggcca ccttcgtcgg cgagaacacc cgcctcgtct ggcccgccga ccaggacttg
    18721 cgacgcgtgc ccgtacacga cccgacaccg gtctaccccc actccctgat ctggcgcacc
    18781 gacaaccccc accccgccct caccaccctg cgcacctacc tcggctccac acggccggcc
    18841 gaccgcgcgg acggggcatg gacgccgcga tgggcgcggt gagggacgcc gggggtggcg
    18901 acggtgtcac gccgccaccg gatgcgcgcc ggtgtcagta gacgatggag acgatccggc
    18961 aggcggcttc ggccagttgg cggtcgccgg tgacgcgggc cccggcgaag gcggcggccg
    19021 gtgggatccc gcgggtacac agccgccatg cgttctccgc atccaggtgg acacgggcgg
    19081 cgggccgacc ggtggccggt tcggcaccgg acgggtagtg gcgtccggaa cgccccggaa
    19141 ggtgctgacg ccgcagctgc cggccgaggt gttcggggtg cgcgccgcgg tgaccggcca
    19201 tccgctcacc ggggacccgc tgatcgcctt cgaccaccgg gagccgctgc ccgccgacgg
    19261 cgggtgacgc ccaccccgcc ccctcacccg gccatgaagt ggctcggccg cccctcgcga
    19321 tacaccagcc gtccgagccg ctcggcctcc gtccggtgca gcaactcccg ccgcccgtcg
    19381 ggatgttcca gcacacacga gtgccagggc gtcagccaca cgtccggcgc ttcgagcagc
    19441 cggatgccga acttggccga gtcccgcggc tgcggatgga tggagagccg gaacgcctcc
    19501 ggatggtggg cggcgatcag ctcgccccag gcgcggctgc gctgcatcac cccgtacgcg
    19561 cgccgccggc agttgcgctg aagtgccgaa cgggtgcccg cgaaggcgac ggagtcctcg
    19621 aagaggaacc gggtgatgcc ctggtacagc cgccgggtcg gctcgtcggt acgggtcagg
    19681 gaccgcaggg tctccaggtc cggggcgtag cgctggtgga ccagggaccg tttggcgtcg
    19741 tgggacagcc gctgaccgta gacatcccgc agatcgaaga catcgagccg ggtcaggccc
    19801 tcgtcgtgga tcagtgtgcg cagcgcgtcg gcataggcgt cgatgtcgcg gtcgggcacc
    19861 tggatgagat cgctgaagac atgtccgtcc gagcagatga ccacccgcgc cccgggcggg
    19921 tggtgggccg cgatccgggc gcagagcgcg tccaggaagc gcagggccag ccgttcgccc
    19981 tcatcgggga ggtggcctaa caccttggcc gggttggggg acttgcaggg gaagcccggc
    20041 agggtgaaga tgatcggctc gcccgcagcc accgggccgg cgagccgccg caggtgggcc
    20101 gggaaggcgt cggggacctc cccgtgggcg gtgtccagcg tgcgccggta gggcaggagc
    20161 gcggcgagca cctcggcaca gcgctcccgg atgtcggagg gcgccaccgg acgcggaggc
    20221 gccggtctgg tcagcacgcg gcatcgggcc cgttcgcacc ggagcccgcg tacgggcagc
    20281 cgccgtaggc caccggcagt cggccgacgc cgcgcgccag tactgccggg gtccattcga
    20341 gctcgtcctc cgggacggcg agccgcaggt ccggcagccg tctcagcaag gtgcccaggg
    20401 cgacctggag ttcgatacgg gcgagcgccg cgccggggca gaagtggatc ccgtggccga
    20461 aggcgagatg cggattgggg gtgcggtcga agtgcagggc gtccgcatcg gggaactgcc
    20521 ggtcgtcgcg gttggccgca ctcagcgaca cgatgacgga gtcgcccgcc gggatgcggg
    20581 tgccgtacag ctcggtgtcc tcggcgaaga accgccaggt ggtcagctcg aaggcgctgt
    20641 catggcgcag gagttcctcg acggcgggcg gcagcagttc gggccggccg gccagcgtgg
    20701 cgagctgcgt ggggtggcgc agcagggtga ccagcgccgt ggtgagctgg tgggtgaccg
    20761 gttcctgtcc cgcgaccagt agttggaaga ccatcgaatc gagctcttcc tggccgatcc
    20821 ggtccgcgtc gcgggccgcc acgagccggg agagcaggtc ctcgccgcgc tcggcgcgct
    20881 tgtggcggac cagatcggcg atgtactgct gaagcccgcg cagccgcgcc tcgtacgccg
    20941 gccggcccgg gtcctcgggc cccacgggct ggacgacctt gccccagtcc cggtcgaagc
    21001 ggtctgcgaa ctccggcggc aacccgatga cttcggcgag cacctggaag gggaagcggg
    21061 cggcgaagac ctcgaccagg tcggctttgc cgccgctgtc cgggagcccg tccagcaggg
    21121 catcggccat cgcctggaag cgcggacgca gcgcctcgac ccgctgcggt gcgaaggcat
    21181 cggtgatcag ccggcgcagc gcggtgtgcc gcggcggatc ctggtggagc agatgcacct
    21241 ggagctggga gtgctggggc tcgggcatga tcgaggcgcg ggcccgccag gccgcgttgc
    21301 cccgcgagtg gtgcttgccc agccgggggt cggtgagggc ccggtgcgcg gcctcgtagc
    21361 cggtgacgag ccaggcgcac accccgctgg ggaagcgcac ccggtggacc gggccgcgct
    21421 cccgcagctc cgcgtacagg ggataggggt cgcgtttgta ctccggcccg tacagctcga
    21481 caggttcgga cgatggggac acgatggctc ctcaacggtg ggggtccggc gcgcggttgg
    21541 cgcggcgttg gagtggtcgg gcaacgggcg cgccgagttc ccgccggggg aggtgatttc
    21601 ggccggggcg ggagaagggg ggcacggcgg caccgtccaa acccagttag tcgggcgcgg
    21661 cggccggtga gttccggcgg cggaacggga caaacctcac gtgcgcacaa cccccggatc
    21721 ggccgctgga cgccgccgtc agctgccacg atgacgcgat gtccagctct tcggccgacc
    21781 gcagtcggcc ccctcttcgc caggccgtca cacggctgct gcccgcccgg tcggtcatcg
    21841 gtttcctcgc gctgctggtg gtgctcggca tgctgtcgta cgcggccggg accgccgtcg
    21901 ggccggtggc ccctgggctg cacccggccg gcggcacccg tacgggagag tccacgccca
    21961 ccgatcacgg ggacatgggc gggatgcacg gcatgggtgc cccggccccc cgcccggtgc
    22021 cggtgggagc accgcgatga cgccggatcc gcggcccgtc accccgtcgc cggacctcgc
    22081 ccccgccccg gtcaacagca ccaccctcac catcggcggg atgacctgtg ccgcctgtgt
    22141 gggccgggtc gagaagaaac tcgggcgtct ggacggggtc gccgcctcgg tgaatctcgc
    22201 caccggccgg gccatggtca gccaccccgc ggcggtctcc gtcaccgacc tcatcagcac
    22261 cgtcgaggcg gccgggttca ccgcacggct ccgtgaacct gcccccgagc cggccccgga
    22321 ggacgggcag ccgcccaccg gccgtcagga cggccaggac ccgagcgacg caccggaaac
    22381 cgcaggcccc caggaccctg cggacgacgg tgcccgcgcc gagtggcacc ggctgctggt
    22441 ggtcgccctg ctctcgctcc ccgtcctggt cctgtcgatg gtgccggcct ggcagttccg
    22501 caactggcag tggctgtgct tcgtgctcgc cgcgcccgtc gcggtctggg gcgccgccac
    22561 cttccacacc cgtgcgctcc gcgggctgcg gcacggcgcg gcgaccatgg acaccctggt
    22621 ctccctcggc gtcgccgcct ccttcctctg gtccgcctat gcgctgttcc tcggcggggc
    22681 cggtgcgccg gggatgacga tgccgttcag cctgctgccc accgcgggcg acggcaccgc
    22741 ccacgtctac ctcgaagccg ccgtcggcgt accgctgttc gtgctggccg gacggcggat
    22801 ggaggccagg gcccggcgcg gcaccggcgc cgcgctccgc gcgctggccg aactggccgc
    22861 caaggacgtc gccgtacgga cgccggaggg cgagcggcgc atcccggtga gccggctgct
    22921 ggtcggcgac cacttcctgg tccggcccgg cgaacgggtc gccaccgacg gcaccgtagt
    22981 ggagggcagc tccgccctgg acctgtccct gatcagcggc gagagccgcc ccgtcgaggt
    23041 cggtccgggc gcggcggccg tcggcggcgc ggtcaactcc ggtggcctgc ttgaggtacg
    23101 ggccgacgcg gtgggcgccg acacccaact cgcccgtatc acccggctcg tcgaggacgc
    23161 ccagaccggc aagaccaagg tccagcggct ggccgacgcg gtggcggccg tcttcgtgcc
    23221 cgccgtcctg accgtcgcgg tcagcgtgct gggcttctgg ctcggcgccg gagccgagcc
    23281 gcaggcggcg atcaccgccg cggtggccgt cctcgtcgtc gcctgcccct gcgcgctcgg
    23341 tctggccacc ccgaccgcgc tgctggccgc caccggacgg ggcgcccagc tgggcatcct
    23401 cgtccggggg ccggaggcgc tggagcggct gcgccgcatc gacaccgtcg tcctcgacaa
    23461 gaccggcacc ctcaccaccg gccggatgag cgtcaccgcc ctcaccccgc gtaccggcgg
    23521 cctcgacgcc gcggcggcac tgcggctggc cgccaccgtc gagcagggct ccgagcatcc
    23581 gctggcccgc gccgtcaccg cctacgcgga cgagcagcgg ccggaccaac cgctgccgcc
    23641 cgtcgcggac ttcagcgcca cgccggggca cggcgtccgc ggcaccgcgg acggccgccg
    23701 ggtggaggtc acccggcccg gtgacgtcac cggtctgccg gcgccactgc ccgacgcggt
    23761 gcacaccgcg gagacggccg ggcacaccgc cgtcctggtc accgtcgacg gcaccccgga
    23821 ggccgtgctc gccatcggtg acgccctccg ccccgacagc tatcgcgccg tcgaccggct
    23881 gcgccgcctg ggactgcggc cggtgctggc caccggcgac cgggccgcga ccgcccgtgc
    23941 ggtggccggc catctcgcca tcaccgaaat ccatgccgag gtccgccccg aggacaaggc
    24001 cgccctcgtc accaccctca aggaacaggg cggccgggtc gccgtcgtcg gcgacggggt
    24061 caatgacgcg gcggccctcg cgctcgccga cctcgggatc gccatgggca gcggcaccga
    24121 cgccgcgatc ggcgcggccg atgtgacgct ggtacgcgag gacctccagg ccatcgccga
    24181 cgccgtgcac ctggcccggc gcaccctggg caccatccgc ggcaacctcg tctgggcctt
    24241 cggctacaac ctcgtcaccc tgccgctcgc cgccgtcggc ctgctcagtc cgatgccggc
    24301 cgcggccgcc atgtccgcca gctcactgct cgtcgtgggc aacagcctcc ggctgcgcgc
    24361 ctggcggccg ggcggaaccg gcacgtccgc ccgccgcccc caccgtcccc gggcacaagc
    24421 acgttgggag acccgatgaa acggctgccc ctctcggccg tcgccgtacc gctgttcacc
    24481 tgcctggtga cgctcaacgt cctcgccctc tggaccgcca ccggcaacgc ggggaccccc
    24541 gcgaagctga gcgtccccga ggggcgggtg ctgatcgccg gcggctccga ggccaccgcc
    24601 gcgttcttca ccatccgcaa caccggcggc gcggacgacg tcctgaccgg cgtcaccggc
    24661 ccgaccggcc atcgcgcgat gctcagccgt accgtcgaca tcgggaacaa cgcccggaag
    24721 atggcgatgg tgcgcaccgt caccgtcccg gccggcgccg ccctgaggat gacgccgacc
    24781 ggcctggacg tcatggtcag cccgccgccc cggctcgcgc ccggcgaccg gctcaccttc
    24841 accctgcact tccgccacag cccaccgcag accgtacggg cccgcgcggt acgccccggt
    24901 gacgggtgaa gcggccggag ccacggcggg actcagggac cgggcccgcg cccgtccctg
    24961 aaccccgccg tccgcgggcg agcggcccct caggccacgg cgtccgcgta gacccgcggc
    25021 gcctcggccg cttccggccg ctccgcatcc gccagcagcg cgaccagcgt ctcccgggcg
    25081 cgcgcgaccc gggaccgcac ggtgccgatg ggacagccca tcaccccgga cgccgccgcg
    25141 tacggcagcc ccagcagctg ggtgaggacg aacgcctccc gccgctccgg cgccagcgcc
    25201 gccagcagtt cggccagcgc gacgccttcg tcgaacccgg gcacgccatg cggctgcacc
    25261 cgttccgcgg ccgtctgcca gtcgtccgtc gcggccagcc ggggccgtac cgcatgggac
    25321 cggatacggt ccgccacgac ccgccgggcg atcgtcagca gccaggtccg cgccgaggac
    25381 cggccctcga atcgcggcag actgcgcagc gcccgca
//
