LOCUS       NZ_BBNO01000002        22235 bp    DNA     linear   CON 19-AUG-2024
DEFINITION  Streptomyces lydicamycinicus strain TP-A0598, whole genome shotgun
            sequence.
ACCESSION   NZ_BBNO01000002
VERSION     NZ_BBNO01000002.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces lydicamycinicus
  ORGANISM  Streptomyces lydicamycinicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Komaki,H., Hosoyama,A., Igarashi,Y. and Tamura,T.
  TITLE     Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite
            Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide
            Compounds
  JOURNAL   Microorganisms 8 (3), 370 (2020)
   PUBMED   32155704
  REMARK    DOI:10.3390/microorganisms8030370 Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a
            producer of anti-MRSA antibiotic lydicamycins
  JOURNAL   Stand Genomic Sci 10, 58 (2015)
   PUBMED   26380643
  REMARK    DOI:10.1186/s40793-015-0046-5 Publication Status: Online-Only
REFERENCE   3  (bases 1 to 866216)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Newbler v. 2.6
            Genome Coverage                   :: 93x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000829715.2-RS_2024_08_19
            Annotation Date                   :: 08/19/2024 02:08:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,323
            CDSs (total)                      :: 7,237
            Genes (coding)                    :: 7,092
            CDSs (with protein)               :: 7,092
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 54 of 145
            Pseudo Genes (incomplete)         :: 123 of 145
            Pseudo Genes (internal stop)      :: 9 of 145
            Pseudo Genes (multiple problems)  :: 39 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:07:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 297876
            Orig. end                         :: 320111
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBNO01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22235
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22235
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22235
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12235](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12235)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(572..1510)
                     /locus_tag="TU31_RS06660"
                     /old_locus_tag="TPA0598_02_02530"
     CDS             complement(572..1510)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152001.1"
                     /locus_tag="TU31_RS06660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02530"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_042151758.1"
                     /transl_table=11
                     /translation="MTLTDEDCLAETLAFNKQFEAAAASRPAREGTPDAALLATLRRNR
                     LGGDTPPVRLPHGQDRVIAGGVTVRIFVPDHVEGVYLHFHGGGWAFGAADGQDERLWRL
                     AEQARLAVVSVDYRLAPEHPFPAGPDDCETAARWLVRHAAAEFGTQRLLVGGESAGAHL
                     AVVTLLRLRDRHGITGAFRAAHLLFGPYDLSMTPSQRAFGSKRLLSNTDTLRRSYELFT
                     PGTGPEQRRDPEVSPLFADLAGLPPARIVVGTEDPLLDDSLFLAGRWQAAGAPVHLGVV
                     AGAMHGFTLFPLTITERELRREREFLSTTGR"
     gene            complement(1672..2472)
                     /locus_tag="TU31_RS06665"
                     /old_locus_tag="TPA0598_02_02540"
     CDS             complement(1672..2472)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999943.1"
                     /locus_tag="TU31_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02540"
                     /product="Fpg/Nei family DNA glycosylase"
                     /protein_id="WP_042150642.1"
                     /transl_table=11
                     /translation="MPELPDVEAFRGILASCAQGRRIRRTEVYDAGVLHGVSAGRLRRE
                     LTGRRFAEPERRGKWLLARTDGPTVLLHFGMTGELVCATPAEPVHAHDRVVFTVTGGRQ
                     LRYRDQRKLQGLWLVDEAGLDRMLRDQGPDAATLTRQGLGAVLAGRRGSLKPVLMDQSA
                     LAGLGNLLVDEILWRARLHPARRAGALSADEHGRLYTELRRTLRSAVRAGRVPPRGSWL
                     TGRRDDPVASCPRCGTALCRKRLAGRGTVWCPDCQPDGTAGGET"
     misc_feature    2476..2491
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(2477..3202)
                     /locus_tag="TU31_RS06670"
                     /old_locus_tag="TPA0598_02_02550"
     CDS             complement(2477..3202)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961905.1"
                     /locus_tag="TU31_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02550"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_042150643.1"
                     /transl_table=11
                     /translation="MSAASTPSPHSPPGARPTTTGRGRPPKLDQARTVEVALALLDEVG
                     LDALTMRRLAEAMDVRAGALYRYFATKHELLTAMAEVLLADCLDRPLRSPEWSERVAEL
                     ARRMRTALLGHRDGARVYAGTHATGAHTLGFADALIGVLREAGFAADDAGRAALTVVHF
                     TLGHTLEEQAARQGADAGPADPARLRAAVTPGQYPHLATALPVLTSTDFTAHFEFGLGL
                     LLQGLRAPGPGTAPPGTGG"
     misc_feature    3242..3258
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            3307..4956
                     /locus_tag="TU31_RS06675"
                     /old_locus_tag="TPA0598_02_02560"
     CDS             3307..4956
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089902.1"
                     /locus_tag="TU31_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02560"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_042151762.1"
                     /transl_table=11
                     /translation="MATEREARVRDAAAEADEVDVLVVGAGPTGLMLGAELALGGVRVQ
                     ILERRTAAQRDSRALTLHPRSIELMDQRGLVERFLSHGRTVPEWHFAGLDTRLDFSTLD
                     TRHGYTLFLAQARTEHLLAERARELEVPVRRGYEVVGLRQDAGGDGGCGDGQGGPAAAG
                     GVEVDVRGPGGGLRTVRARYVVGCDGGRSAVRQAAGIAFPGTDETLTGVLGDFAVVDPA
                     ALDRARAHGVLVAPLEADGPANGPAEGRTGGLTRLVLIDPRRMRTPSAEPLTPEEFRSS
                     LVDLCGTDCGVARPRWLSRFGNATRLAARYRAGRVLLAGDAAHIHFPAAGQGLNTGLQD
                     AMNLGWKLAAEIHGWAPPGLLDSYHAERHPVGRAVTENTEVQTLLMELTRLPPYQRPAA
                     ALRTLLTELLGIEEVNRRLAGRISALDTVYPPTATDADALAGRRMPDIALTAAGSAAVR
                     AHELLPPGRFVLLDLAGDEQLRRTVTPGWGPRVTALTVTHHDHRTDLDGVREILLRPDG
                     HIAWATRTPALSDRRTERHRALTDWAGTPAQG"
     gene            complement(5002..5760)
                     /locus_tag="TU31_RS06680"
                     /old_locus_tag="TPA0598_02_02570"
     CDS             complement(5002..5760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089897.1"
                     /locus_tag="TU31_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02570"
                     /product="hypothetical protein"
                     /protein_id="WP_042150645.1"
                     /transl_table=11
                     /translation="MRRKTAFLGALALTGGLVAFAPSGAHAITGVITYHTRPDNRPHEI
                     LDPGDDHCYGVGDGYGEVDNDTPTDLVLYNGRDCTGSVVTVVPARGWLTARFGSLQLSS
                     DGPREEAPSADEDRRDDQDGRDDQDRGDDQDRRDDQDRRDDQDRRDDRDRSDSPDRSDD
                     RDPAADDRDPAVGDRPNRSDGQDPADRPDSSGSSDPSDDLDHSDHPGDSQDLDRSENRD
                     QPASSASPVDPVNAGTPGRHGRPGRPGAAG"
     gene            complement(6057..8183)
                     /locus_tag="TU31_RS06685"
                     /old_locus_tag="TPA0598_02_02580"
     CDS             complement(6057..8183)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981083.1"
                     /locus_tag="TU31_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02580"
                     /product="nuclease-related domain-containing DEAD/DEAH box
                     helicase"
                     /protein_id="WP_042150647.1"
                     /transl_table=11
                     /translation="MAAGSAPGGSAGASAGRRAQQARRQERLLREQWQAARARAERWEA
                     ASEGERRVAAQLLMLVERGWRLLVDRRWPGTRAANVDMLLIGPGGVFVIDVKNWRAAPE
                     TCGGRLRAGGFSRDEHRRKLLAVTKAAESAVASLGMSPVAVRPLLAFAGHRVDAELGRV
                     RLLGEREIGPALLSERTRLSAESVRALTEHLERVFPEYEAPAAAPTPDAATPGSASRIA
                     DAASDGLFDLDGLRDAALDEARRAPIERWMTFLDPDQLALVRRNWAGPARISGPAGTGK
                     TVIALHRAAYLAQRTNGRILYVTFANNLPRVQATFLKTMAPAVADRVDFRSLHSWAQEY
                     LRDRGVPVHLHKEKAETAFSFAWKHVGRNSCLTEIDPQHPYWREEIDYVIKGRGITSFD
                     AYAALPRRRRRAGLRRPHRQAVWSLYEAYEAQRTERAVHDFNDVLSLALAEAAGRIGHS
                     AYTAVVVDEVQDLTLVGVRLLHALVGDAPNGLLLVGDGQQAVYPGGFRLSDAGIDIRGD
                     RGQVLRANYRNSKEIVDTALSVVAEDAFEDLDGLRTPGRRDIDLTYHDGEVQRAVLPTT
                     AAHDEALLTALRGLTPQELAGSAVLCPAKRAIEHYQRLLTRAGLRVCSLDRYDGHPVEA
                     VKLGSYRRAKGLEFKRVYLPQHDTPPPMGTPDGRTPAETAHERAELARSQLYVAMTRAR
                     DVLWLGSVRPVREN"
     misc_feature    complement(8097..8099)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8326..8520)
                     /locus_tag="TU31_RS06690"
                     /old_locus_tag="TPA0598_02_02590"
     CDS             complement(8326..8520)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949726.1"
                     /locus_tag="TU31_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02590"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_042150649.1"
                     /transl_table=11
                     /translation="MTDSLRWSKSSYSNNGGQCIEWAPEHAAATGEFLVRDSKDPNGPQ
                     LALTRQGFAALVEFAKSQG"
     gene            complement(8517..9353)
                     /locus_tag="TU31_RS06695"
                     /old_locus_tag="TPA0598_02_02600"
     CDS             complement(8517..9353)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045692.1"
                     /locus_tag="TU31_RS06695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02600"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_042150651.1"
                     /transl_table=11
                     /translation="MNRKELTPDSSPQAAFGARLRSSREARGWTQDELAELMGYSSTHV
                     SAVETARKPPTLRFSRSADRTFGTEGTVDTFERQWREIRHGSLLEGFPEYVGHEGRAAE
                     IRLYEVGIIPGLLQTPEYASVLAGSAVKRGAITPEQADERVSLIAERQAALVRTRPPLI
                     FVVLDESCIRRPIGGPAVMDAQLARLVEFAELPNTVLHVAPFDMGERRPFDLPITVLTL
                     PDRSLMSYAESAQRGHLERESTSVLPILTAYHQLQADARSQAASVAMINDLRKGTP"
     misc_feature    complement(8535..8537)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9349..9364
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.15"
                     /tool="antismash"
     misc_feature    complement(9349..9366)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.54"
                     /tool="antismash"
     misc_feature    complement(9428..9444)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            9485..9658
                     /locus_tag="TU31_RS38475"
                     /old_locus_tag="TPA0598_02_02610"
     CDS             9485..9658
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS38475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_02_02610"
                     /product="hypothetical protein"
                     /protein_id="WP_158894275.1"
                     /transl_table=11
                     /translation="MDVGLPEDADPEGPERADDSDSDSDSDSDSETLTHLRARVHQDYA
                     RRQRHGQLGRSL"
     misc_feature    9497..9499
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9655..9828
                     /locus_tag="TU31_RS39055"
                     /old_locus_tag="TPA0598_02_02620"
     CDS             9655..9828
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644052.1"
                     /locus_tag="TU31_RS39055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02620"
                     /product="hypothetical protein"
                     /protein_id="WP_181018557.1"
                     /transl_table=11
                     /translation="MSCTTCDTLRAVLAVAERHGDRSKAVDCRVLLRRHPEHDDVPVEG
                     KAEREAERKGEP"
     gene            complement(10001..12235)
                     /locus_tag="TU31_RS06700"
                     /old_locus_tag="TPA0598_02_02640"
     CDS             complement(10001..12235)
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604221.1"
                     /locus_tag="TU31_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02640"
                     /product="terpene synthase family protein"
                     /protein_id="WP_042150653.1"
                     /sec_met_domain="T1TS (E-value: 3e-81, bitscore: 269.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYTPHPARLNPHLETARTHSRKWARDLGMLEGSGIW
                     EEKDLDAHDYALLCSYTHPECDADALSLVTDWYVWVFFFDDHFLEKFKRTLDRKGGKEY
                     LDRLPAFMPMDLAAPLPEPANPVEAGLADLWMRTVPQMSMDWRRRFAESTEHLLNESLW
                     ELSNINIHRVPNPVEYIEMRRKVGGAPWSAGLVEYATGAEVPASVAASRPLRVLRDTFS
                     DAVHLRNDLFSYQRETEDEGELSNGVLVLENFLDCTTQEAADAVNDLITSRLQQFENTV
                     LAELPPLFLEKGLDPASCAKVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGAAADSSRPW
                     SPFSFGGLGTSAADLKTALATAGALRLRSGTHLPHQTVGPSQLPEFCMPFTTTLSPHLE
                     GARLRLIDWAHRMGLLQPQPGVPLSDIWDEPAMVRHDLALCAAGIHPDATPEQLDLDAA
                     WLAWGTYADDYYPAVFGRTRDLASAKVCTERLSALMPLDSGTAPPEPVNALERGLADLW
                     SRTTAGMAPEARRAFRETVDTMTASWLWEIGNQIQHRIPDPVDYIEMRRATFGADLTMS
                     LSRLAHGRRVPPEVYRSGPLRSLENAAADYAGLMNDVFSYQKEIEYEGEVHNGILVVQT
                     FFGCDYPTALHIVDDLMTSRMREFQHVAAHELPVVYDDFQLSPEAREAVDGYVRELEHW
                     MAGILIWHRDCRRYRASELRHPTGSPGRLGAPTGLGTSAAGLFRSAVKAG"
     gene            complement(12390..13238)
                     /locus_tag="TU31_RS06705"
                     /old_locus_tag="TPA0598_02_02650"
     CDS             complement(12390..13238)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089894.1"
                     /locus_tag="TU31_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02650"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_042150655.1"
                     /sec_met_domain="RimK (E-value: 7.7e-08, bitscore: 27.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRICLLTADPGHPLLAAVTGLLTPDHRVETLDPGAAGPGPDLSAL
                     ADVYLLKARTPRALALAALLEEHGAPVLNSAAATARCQDRVAMAAVARAAGLPFAATRA
                     VATLGELAAAGAPDGPLVIKSRFSRRRDLVTRADSAVRLRELAADWAEEPVVVQDFTPN
                     SGWDHKLWVVDGQLFAALRRSELAPDGRGPNLPLPVGELPAGWTAAALQVGEVFGLDVY
                     GVDLLDAGGGAPLIVDINAFPGIRGQAGAPEALAALALRTAARGRAGGADERKVSQVSE
                     K"
     gene            complement(13235..14248)
                     /locus_tag="TU31_RS06710"
                     /old_locus_tag="TPA0598_02_02660"
     CDS             complement(13235..14248)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089893.1"
                     /locus_tag="TU31_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02660"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_042150657.1"
                     /sec_met_domain="RimK (E-value: 1.1e-07, bitscore: 27.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLCFLVEEQYRHDGMPLEVIHQLRAWDHQVDVVWPGRSLIRISE
                     AIRAGSHDAWVLKTVSGGPGLTLLEAAASVGLTTVNDVRAIRGVRDKALAAVIARSKGL
                     PVPVTYAAARPEEFAEIAEAEFPLVVKPADGSSGRAVRLVATPDRLLEPGGPDGPAGGL
                     LIAQPYVPNSGTDLKVYSVAGELYATERCSPLHPAHAVRERQVPLTPEVARITAEIGAV
                     FGLDLYGVDILLGPDGPVVVDINDFPSFRQVPDAVARVSAAVLDLARNGARGREAFGGE
                     TSVREDAPDTRAAGRTGAPAPPSTARTSAAAAPPPPFTASPVPRPTRPAASIGGGR"
     gene            complement(14420..15259)
                     /locus_tag="TU31_RS06715"
                     /old_locus_tag="TPA0598_02_02670"
     CDS             complement(14420..15259)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-267). E-value:
                     1.5e-30. Score: 98.6. Matches aSDomain:
                     nrpspksdomains_TU31_RS06715_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059054.1"
                     /locus_tag="TU31_RS06715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02670"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_042151766.1"
                     /sec_met_domain="PF00561 (E-value: 6.8e-27, bitscore: 90.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.9e-17, bitscore:
                     58.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFSAHDGTTLAYHVSGDGPPLICLPGGPMQDSAYLGDLGGLAA
                     HHRLIRLDLRGTGGSAIPADPASYRCDRLVDDVEALREHLGLESVDLLAHSAGANLAVL
                     YAGRHPDRVGKMALITPSVLAVGLVITGDLRRETARLRHEEPWFAPAFAALEALVAGKP
                     ADDCRERIAPFFYGRWDAAAQSHRAAEDGQRNAAAAAVFGAEGAFDPEATRAALAAFGR
                     PVLLLAGEVDLGAPPPAMAEFTDLFPHARLVVQPGAGHFPWLDDPGRFAAATTAFLA"
     aSDomain        complement(14459..15199)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS06715_Abhydrolase_1.1"
                     /evalue="1.50E-30"
                     /label="TU31_RS06715_Abhydrolase_1.1"
                     /locus_tag="TU31_RS06715"
                     /protein_end="267"
                     /protein_start="20"
                     /score="98.6"
                     /tool="antismash"
                     /translation="PPLICLPGGPMQDSAYLGDLGGLAAHHRLIRLDLRGTGGSAIPAD
                     PASYRCDRLVDDVEALREHLGLESVDLLAHSAGANLAVLYAGRHPDRVGKMALITPSVL
                     AVGLVITGDLRRETARLRHEEPWFAPAFAALEALVAGKPADDCRERIAPFFYGRWDAAA
                     QSHRAAEDGQRNAAAAAVFGAEGAFDPEATRAALAAFGRPVLLLAGEVDLGAPPPAMAE
                     FTDLFPHARLVVQPGAGHFPWLDDP"
     gene            15464..15985
                     /locus_tag="TU31_RS06720"
                     /old_locus_tag="TPA0598_02_02680"
     CDS             15464..15985
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089892.1"
                     /locus_tag="TU31_RS06720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02680"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_107070632.1"
                     /transl_table=11
                     /translation="MDREQSGGPVTHKAVPFDDLDRKIVAALIDNGRASFAEIGTAIGL
                     SSTAVKRRVDRMRENNVITGFTATVRPAALGWLTEAYVEVYCDSAAPPRRLAEVVRNHP
                     EIAAAMTVTGGADALLHVRATDVEHFEEVLERIRTEPFIRKTISYMVLSHLLPDSPEAG
                     ARQSSEGTVR"
     misc_feature    16176..16189
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.54"
                     /tool="antismash"
     gene            16240..17064
                     /gene="ddaH"
                     /locus_tag="TU31_RS06725"
                     /old_locus_tag="TPA0598_02_02690"
     CDS             16240..17064
                     /EC_number="3.5.3.18"
                     /GO_function="GO:0016403 - dimethylargininase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ddaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059544.1"
                     /locus_tag="TU31_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02690"
                     /product="dimethylargininase"
                     /protein_id="WP_245698440.1"
                     /transl_table=11
                     /translation="MSRVSRPRRYLVCEPRHFAVHYAINPWMRADVPVDTALAGRQWET
                     LMGTYRAHGHTVETVPPVPGLPDMVFAANSALVVGGRVFGSHFHAPQRRPESTEYETWF
                     KAAGYDVYRPESPCEGEGDLVPAGRFILAGTGFRTTPAAHREVQEFFGMPTIGLQLVDP
                     YFYHLDTALFVLDESPETGEAHIAYYPEAFSSGSREVLRRLFPDAVLATREDAMAFGLN
                     SVSDGRHVFVAPQATGLIAQLSAHGYVPVPVDLSEFHKAGGGIKCCTQEIRS"
     gene            17061..18296
                     /gene="rocD"
                     /locus_tag="TU31_RS06730"
                     /old_locus_tag="TPA0598_02_02700"
     CDS             17061..18296
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (37-358). E-value: 8.4e-102.
                     Score: 332.6. Matches aSDomain:
                     nrpspksdomains_TU31_RS06730_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089890.1"
                     /locus_tag="TU31_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02700"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_042150662.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-116, bitscore:
                     385.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTRTVPAQAPRSSAELIQAESPVLAHNYHPLPVVVARAEGVW
                     VEDVEGRRYLDMLAGYSALNFGHRHPALIEAAHRQLDQLTLTSRAFHNDRLAGFAEGLA
                     ELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPADRATIVVAGGNFHGRTTTIVGF
                     SDDDTARVGFGPFAPGFRTVPYNDLAALEAALDETTAAVLIEPIQGEAGVLIPDDGYLT
                     GVRELTRRNGCLFIADEIQSGLGRTGTTLAVEHESVVPDMLLLGKALGGGIVPVSAVVA
                     RREVLGVLGPGQHGSTFGGNPLAAAVGSAVIELLATGEFQRRAAELGAVLRDGLAALTG
                     KGVTGFRARGLWAGVDIDPALGTGREISERLLKEGVLVKDTHGSTIRLAPPLTITDGEL
                     TSALGSLERALG"
     aSDomain        17172..18134
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TU31_RS06730_Aminotran_3.1"
                     /evalue="8.40E-102"
                     /label="TU31_RS06730_Aminotran_3.1"
                     /locus_tag="TU31_RS06730"
                     /protein_end="358"
                     /protein_start="37"
                     /score="332.6"
                     /tool="antismash"
                     /translation="VARAEGVWVEDVEGRRYLDMLAGYSALNFGHRHPALIEAAHRQLD
                     QLTLTSRAFHNDRLAGFAEGLAELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPA
                     DRATIVVAGGNFHGRTTTIVGFSDDDTARVGFGPFAPGFRTVPYNDLAALEAALDETTA
                     AVLIEPIQGEAGVLIPDDGYLTGVRELTRRNGCLFIADEIQSGLGRTGTTLAVEHESVV
                     PDMLLLGKALGGGIVPVSAVVARREVLGVLGPGQHGSTFGGNPLAAAVGSAVIELLATG
                     EFQRRAAELGAVLRDGLAALTGKGVTGFRARGLWAGVDID"
     gene            complement(18403..18801)
                     /locus_tag="TU31_RS06735"
                     /old_locus_tag="TPA0598_02_02710"
     CDS             complement(18403..18801)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TU31_RS06735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TPA0598_02_02710"
                     /product="hypothetical protein"
                     /protein_id="WP_042150663.1"
                     /transl_table=11
                     /translation="MTRSKLLRALTVAGTIALSAVATTPAAHAAADACTHDWSGPQICI
                     AADGQNGTANPGHVTASWTNPPKSRKSATVYLYQPDGYTYSFKAKRSGGEIVGHTVPGI
                     QSDGNLCVRFKGSSHKACIDIRNRNGSF"
     misc_feature    complement(18891..18904)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            complement(18924..19523)
                     /locus_tag="TU31_RS06740"
                     /old_locus_tag="TPA0598_02_02720"
     CDS             complement(18924..19523)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556212.1"
                     /locus_tag="TU31_RS06740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02720"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_042150664.1"
                     /transl_table=11
                     /translation="MDLDEARTRILDAAEKLFYDRGIQSVGMDELRTAAGVSLKRLYQC
                     FPAKHDLVETYLRRRDTRWRTALAEYVDAHADGPAGRPLAVFDWLGEWFAEDGFRGCAF
                     LNACGELGATSDRVGRVAREHKEALLAYVTGLVRAVPVAEPEALARQLVLLIDGAIAGA
                     ALMGEPGAARQARTAAAVLIEAAGCGGANGVPHKGN"
     misc_feature    complement(19546..19559)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(19549..19567)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.13"
                     /tool="antismash"
     misc_feature    complement(19580..19593)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            19619..20077
                     /locus_tag="TU31_RS06745"
                     /old_locus_tag="TPA0598_02_02730"
     CDS             19619..20077
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134804.1"
                     /locus_tag="TU31_RS06745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02730"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_042150665.1"
                     /transl_table=11
                     /translation="MAPRAPFPPFDEPGARQKVQAAEDAWNTRDPERVALAYTEDSVWR
                     NRDTFLTGRDEIVAFLRRKWARELDYALRKELWSYSGNRIAVRFQYECHDAAGQWWRSY
                     GNELWEFDADGLMRRREAGIHDVAITEADRRIFGPRAEEERGHPLPFR"
     gene            20309..21838
                     /locus_tag="TU31_RS06750"
                     /old_locus_tag="TPA0598_02_02740"
     CDS             20309..21838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089881.1"
                     /locus_tag="TU31_RS06750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TPA0598_02_02740"
                     /product="IPT/TIG domain-containing protein"
                     /protein_id="WP_052718837.1"
                     /transl_table=11
                     /translation="MSTNLLAPAQTLLEPATSPGPVRATAAPVTFLAVTTIPVGSNPVG
                     LAFIPNGDLYVANSGSSNVQTIDTATDTVIGAAIPTGTTPAWLTVAPNGNAYVPNNISN
                     NVTVIDTATSTVLTTIALSGGPAAAAVIPSGNVYVSRFGANSVQEISTATNTTVGAAIP
                     TGSGPVGIAVAPNGKAYVANRNGNSVTVIDTNTATVVTTIPGFNQPNFVAIGPSGDAYV
                     ANIGSNNVSVIDTTTDTIATTIPVGTNPWGITVGPDGNAYTANRGSNNVSVIDTTTNTT
                     IGAPIPVGSQPIALVVAPNNKVYVTNIAGASVSVIQFDPTISSITPNSGPVTGGTVVTI
                     TGTNLTGASVDIGGNPATGVTVNATGTQLTATTPPGVPGPADVTVTTPGGSTTLVGGFT
                     YFVPVHATSLTATPALTKLFPPHVYFPFLTATLTDQVTGLPVPNQPILFKAGSNVLGIA
                     NTDAQGVARVNETLTLTLILLNGGYEVSFAGAATPTAILSPSSDTAPVIEP"
     misc_feature    21996..22011
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    21997..22011
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.83"
                     /tool="antismash"
ORIGIN
        1 ggtgcggcac caggcgatga ggtaccactt gccgtttgcg gtgagcagtc cggccggttc
       61 caccgcgcgg tcgcttacgc gtcctgccgc gtcggtgtag gacagccgca gcaccgtgtg
      121 ggtggtgagg gcctgttcca ccgcggtgcg gaccgtggtg tgggcgggcg ggggcagcgt
      181 gacgatccgg gcggcgagtt gctgtgcggc cgccgaggcg gggccggaca gcgaagccgc
      241 gatcttctgg gccgccgtgc gggccgcggc ggcgtacggg gcggcggcgt cggccgcggc
      301 cagggcgacg gccagggccg aggcttcctc ggtggtgaag tggatcgggg gcagggtcat
      361 ttccgggtcg atcgaccagc cgccgccccg cccgggggtg gtgcgtaccg ggacaccggt
      421 ctccatcagc gcctggaggt cgcgctgcac cgtgcgcgtg ctcacctcga accgcgcggc
      481 gagcgccgcg accgtcagcg gccgcggcgc cgccgcacgc aactcttcca ccagcgcata
      541 gagccgggca gtgcggttca tccgggcgac gctaccgtcc cgtggtggac aggaattccc
      601 gttcgcgccg cagttcgcgc tcggtgatgg tcagcgggaa gagggtgaag ccgtgcatgg
      661 cgccggcgac gacaccgagg tgtacgggcg caccggccgc ctgccaccgc ccggccagga
      721 acagcgagtc gtccagcagc ggatcttcgg taccgacgac gatccgtgcg ggtggcagac
      781 cggcaaggtc ggcgaagagc ggtgagacct cggggtcacg gcgttgttcc ggccccgtgc
      841 cgggtgtgaa cagctcgtag ctccgccgca gcgtgtccgt attgctcagc agccgctttg
      901 atccgaacgc gcgctggctc ggcgtcatgg acaggtcgta ggggccgaag agcagatggg
      961 cggcccggaa cgcgccggtg atgccgtgcc ggtcgcgaag gcgcagcagc gtcacgacag
     1021 cgaggtgggc accggccgat tcgcccccga ccagcagccg ttgggtgccg aactcggccg
     1081 cggcgtgccg caccagccac cgggcggccg tctcgcagtc gtcgggcccg gcggggaacg
     1141 ggtgttccgg cgcgaggcgg tagtccacgc tgaccacggc cagccgggcc tgctcggcga
     1201 gtcgccacag ccgctcgtcc tgtccgtccg cggcaccgaa cgcccagccg cctccgtgga
     1261 agtgcagata gacgccttcc acgtgatccg gcacgaagat ccgtaccgtc actccgcccg
     1321 cgatgacgcg gtcctggccg tgcggcagcc ttaccggtgg tgtgtcgcca ccgagccggt
     1381 tgcgccgaag ggtggccagc agggctgcgt ccggcgtccc ttcgcgcgcc gggcggctcg
     1441 cggctgcggc ctcgaattgc ttgttgaatg ccagggtctc ggcgaggcag tcctcatcgg
     1501 tgagcgtcat accgcccacg ctcgcagccg tccgcgacaa cgccctgtca ccctttcctg
     1561 gtgagccgcg ccacacttct gtctgccgcc tgccgcctgc cgcctgccgc gtcaccgccc
     1621 cgctccgctg accgcgtgca cggcaccagg cgccgtgcgg cggaacggag ttcaggtctc
     1681 gcccccggcg gtcccgtcgg gctggcagtc ggggcaccac accgtgccgc ggcccgcgag
     1741 acgcttccgg cacagcgccg tgccgcagcg cgggcagctc gccacggggt cgtcgcggcg
     1801 tcccgtgagc caggatccgc gcggcggtac gcggcccgcg cggaccgccg accgcagggt
     1861 gcggcgcagc tccgtgtaca gccggccgtg ctcgtcggcg gagagcgcac cggcccgtcg
     1921 ggcggggtgc agccgggcgc gccacaggat ctcgtcgacg agcagattgc cgagcccggc
     1981 cagtgccgac tggtccatga ggaccggctt gaggctgccg cgccgcccgg cgagcaccgc
     2041 cccgagcccc tgacgggtca gcgtcgccgc atccggcccc tggtcgcgca gcatccggtc
     2101 cagcccggcc tcgtcgacca gccacaggcc ctggagtttc cgctggtcgc ggtagcgcag
     2161 ctggcgtccg ccggtcaccg tgaacaccac ccggtcatgg gcgtgcaccg gttcggcggg
     2221 ggtggcgcac accagctcac cggtcatccc gaagtgcagc agcacggtgg ggccgtcggt
     2281 gcgcgcgagc agccacttgc cgcgccgctc cggctcggcg aaccggcggc cggtcagctc
     2341 gcggcgcagc cgcccggcac tcaccccgtg cagcacgccc gcgtcgtaca cctcggtccg
     2401 ccggatgcgc ctcccctgtg cacaggaggc caggattccg cggaacgcct cgacgtcggg
     2461 cagctcgggc atggcgtcac ccgccggtcc ccgggggcgc ggtgccgggc ccgggggcgc
     2521 gcaggccctg gaggagcagc cccagcccga attcgaagtg ggcggtgaaa tccgtgctgg
     2581 tcaacaccgg caacgcggtg gcgagatggg ggtattggcc gggggtcacc gccgcgcgca
     2641 gccgtgccgg gtccgccggg ccggcgtccg cgccctggcg cgcggcctgc tcctccaggg
     2701 tgtggccgag ggtgaagtga acgaccgtga gggcggcccg gcccgcgtcg tcggcggcga
     2761 agcccgcctc ccgcagcacg ccgatgaggg cgtcggcgaa accgagggtg tgtgcgccgg
     2821 tggcgtgcgt accggcgtag acgcgggcgc cgtcgcggtg accgaggagc gccgtgcgca
     2881 tccggcgggc cagttcggcc acccgctcgc tccattccgg cgaccggagc ggccggtcga
     2941 gacagtcggc cagcagcact tcggccatcg cggtcagcag ttcgtgcttg gtggcgaagt
     3001 agcggtagag cgcaccggcc cgtacgtcca tggcctcagc cagccgccgc atggtgagcg
     3061 cgtccagccc gacctcgtcc agcagcgcca gggccacctc gacggtccgc gcctggtcga
     3121 gcttcggggg ccggccccgc ccggtggtgg tgggccgggc gccgggaggg ctgtgcgggc
     3181 tgggggttga cgcggcgctc atggccctca ttatagtgaa cgacgttcac gtgaacagcg
     3241 ttcactaaat agcgggcaga aaggcggggg cagccgatgg atgccgcttt cgagagcgag
     3301 gccgagatgg cgaccgagcg ggaggcccgg gtgagggatg ccgctgccga ggccgacgag
     3361 gtcgatgtgc tcgtggtggg tgcgggaccg accgggctga tgctcggtgc cgagctggca
     3421 ttgggcggcg tacgggtgca gatccttgag cggcggaccg cggcccagcg ggattcacgg
     3481 gcgctgaccc tgcacccgcg cagcatcgag ctgatggacc aacggggcct ggtggaacgc
     3541 ttcctgtcgc acggccgcac cgtcccggaa tggcacttcg ccggactgga cacccggctg
     3601 gacttcagca cgctggacac ccggcacggc tacaccctgt tcctcgccca ggcccggacc
     3661 gaacacctgc tggcggagcg cgcccgcgaa ctggaggtgc cggtccggcg cggatacgag
     3721 gtggtcgggc tgcgccagga cgccggcggt gacggaggct gcggcgacgg gcagggcggg
     3781 cccgcagccg cgggcggtgt cgaggtggac gtccgcgggc ccggcggcgg cctgcggacc
     3841 gtccgcgcac ggtatgtggt cggctgcgac ggcggacgga gcgcggtgcg gcaggccgcc
     3901 ggcatcgcgt tccccggcac cgacgagacc ctgaccggcg tactggggga tttcgcggtc
     3961 gtcgacccgg cagccctcga ccgtgcgcgc gcccatggcg tcctggtcgc cccgctggag
     4021 gcggacggac ccgcgaacgg cccggcagag gggcggaccg gcggcctcac ccggctcgtc
     4081 ctcatcgacc cgcggcggat gcgcacaccg tccgccgaac cgctgacacc ggaggagttc
     4141 cgcagctccc tggtggacct ctgcggcacc gactgcgggg tggcgcggcc ccgttggctg
     4201 tcgcggttcg gcaacgccac ccgtctcgcc gcccgttacc gcgccggacg cgtcctgctg
     4261 gccggcgacg ccgcccatat ccacttcccg gccgccgggc agggcctcaa caccgggctc
     4321 caggacgcga tgaacctggg ctggaagctc gccgccgaga tccacggctg ggccccgccc
     4381 ggactgctcg acagctacca cgccgaacgg catccggtcg gacgcgcggt caccgagaac
     4441 accgaggtcc agacgctact gatggagctg acccggctcc ccccgtacca gcgcccggcc
     4501 gccgcgctgc gcacgctgct gacggaactc ctgggcatcg aggaggtcaa ccgccgcctg
     4561 gccgggcgga tttccgcgct cgacacggtc tatccgccca ccgccaccga cgccgacgcc
     4621 ctggcgggac gccggatgcc cgatatcgcc ctgacggcgg ccggctccgc ggccgtccgc
     4681 gcccatgagc tcctcccgcc cggccggttc gtcctgctgg acctcgcggg tgacgagcag
     4741 ctgcggcgga ccgtcacccc gggctggggt ccccgggtga ccgccctgac cgtcacccac
     4801 cacgaccacc gcaccgacct cgacggggta cgggagatcc tcctgcgccc cgacggccat
     4861 atcgcctggg ccacccgcac accggccctg tcggaccgcc gcaccgagcg ccaccgcgcc
     4921 ctgaccgact gggccggtac ccccgcccag gggtagcccg gcggcctcgg gccgtccgcc
     4981 cctcagcccc gtctccccac ctcagcccgc cgcccccggg cgtcccggtc gtccatggcg
     5041 ccccggggtc cccgcgttga ccgggtccac cggacttgcc gaacttgccg gctggtcgcg
     5101 gttctccgag cggtcgaggt cctgcgagtc ccccgggtgg tcggagtggt ccaagtcgtc
     5161 cgaggggtcg gagctgccgg aggagtccgg gcggtccgcg gggtcctggc cgtcagagcg
     5221 gttcgggcgg tcgccgacgg cggggtcccg gtcatcggcg gcggggtctc ggtcgtcgga
     5281 acggtccggg ctgtccgagc ggtcccggtc atcgcgacga tcctgatcgt cccgacggtc
     5341 ctggtcatcg cgacggtcct ggtcgtcccc acgatcctga tcgtcccgac catcctggtc
     5401 atcgcgacgg tcctcgtcag cggagggggc ctcctcccgg gggccgtccg agctcagctg
     5461 gaggctgccg aacctcgcgg tgagccagcc gcgggcgggc acgacggtca ccacggagcc
     5521 ggtgcagtcg cggccgttgt acaggacgag gtcggtgggg gtgtcgttgt ccacctcgcc
     5581 gtagccgtcc cccactccgt agcagtggtc gtcgccgggg tcgaggatct cgtgcggccg
     5641 gttgtcgggc cgggtgtggt acgtgatgac gccggtgatg gcatgcgcgc cggagggagc
     5701 gaacgcgacg agccccccgg tgagagccag cgcaccaagg aaagcggtct tgcgtcgcac
     5761 agtcggaact cctgtcagcc atggcggcgg gccggtcctg ggccaggccc ttacgggatg
     5821 tcgccatgtg gggttcccga cgccctctcg ggatattccc accgaagggg agattcaccg
     5881 tgcagcagga cattacgggt ggcatcggcg gttcgggaga ggcgacgggg gccggcgacg
     5941 gggccggggc tggccgtccg cgccaccgcc ccatcgccct cgcccaagcc ctctcccaag
     6001 ccctcgcctt cgcccgtacg ggcccgcccg ccgcgccgcc ggccgcctcc cgtcactcag
     6061 ttctcccgca ccggccggac gctgcccagc cagaggacgt cgcgggcgcg ggtcatggcg
     6121 acgtagagct gactacgggc cagttcggcg cgctcgtggg cggtttcggc gggggtgcgg
     6181 ccgtccgggg tgcccatggg cggcggggtg tcgtgctgcg gcagatagac gcgcttgaat
     6241 tccaggccct tggcacggcg gtaactgccg agtttgacgg cctccaccgg gtgcccgtcg
     6301 tagcggtcca gtgagcagac ccgcaggccg gcccgggtga ggaggcgctg gtagtgctcg
     6361 atggcgcgct tcgcggggca gaggacggcg gaaccggcca gctcctgcgg ggtcaggccg
     6421 cgcagcgcgg tcagcagcgc ctcgtcgtgc gcggcggtcg tgggcaggac ggcgcgctgc
     6481 acctcgccgt cgtggtaggt caggtcgatg tcccgacggc ccggggtgcg cagcccgtcg
     6541 aggtcttcga aggcgtcctc ggcgaccacg gagagcgcgg tgtccacgat ctccttgctg
     6601 ttgcggtagt tggcacgcag cacctggccg cggtcgccgc ggatgtcgat gcccgcgtcc
     6661 gagaggcgga acccgcccgg gtagacggcc tgttggccgt cgccgaccag gaggagaccg
     6721 ttgggggcgt cgcccaccag ggcgtgcagc aggcgcaccc cgacgagggt caggtcctgg
     6781 acctcgtcca cgacgacggc cgtgtacgcg ctgtgcccga tccggccggc cgcctcggcg
     6841 agcgcgaggg agagcacatc gttgaagtcg tggacggcac gctcggtgcg ctgcgcctcg
     6901 tacgcctcat acagggacca gacggcctgc cggtgcgggc ggcgcagccc ggcgcggcgg
     6961 cgacggcgcg gcagcgcggc gtacgcgtcg aaggaggtga tgccgcggcc cttgatgacg
     7021 tagtcgatct cctcccgcca atacgggtgc tgcggatcga tctcggtcag gcagctgttc
     7081 cggccgacgt gtttccaggc gaagctgaag gccgtctccg ccttctcctt gtgcaggtgg
     7141 accggaactc cccggtcgcg caggtactcc tgtgcccagg agtgcaggct gcggaagtcg
     7201 acccggtcgg ccaccgccgg ggccatggtc ttcaggaagg tggcctggac acggggcagg
     7261 ttgttggcga acgtgacgta caggatgcgg ccgttggtgc gctgggcgag gtaggcggcg
     7321 cggtgcaggg cgatgaccgt cttgccggtg ccggccgggc cgctgatcct ggccggaccg
     7381 gcccagttgc gccgtacgag ggcgagctgg tccgggtcga ggaaggtcat ccaccgctcg
     7441 atgggcgccc ggcgcgcctc gtcgagcgcg gcatcccgca gcccgtcgag gtcgaagagg
     7501 ccgtcggacg ccgcgtccgc tattcgggag gcggagcccg gagtggcggc gtccggggtg
     7561 ggggcggcgg ccggcgcctc gtactcgggg aagacccgct ccagatgctc ggtgagggca
     7621 cggacggact cggcggacag ccgggtgcgc tccgacagca gcgccggccc gatctcccgc
     7681 tcgcccagca gccgcacccg gcccagctcc gcatcgaccc gatgccccgc gaaggccagc
     7741 agcggccgca ccgccaccgg cgacatcccc agcgacgcca ccgcgctctc ggcggccttg
     7801 gtgaccgcga gcagcttgcg gcggtgctcg tcgcgggaga accccccggc ccgcagccgg
     7861 ccgccgcagg tctccggtgc ggcccgccag ttcttgacgt cgatgacgaa gactccgccg
     7921 gggccgatca gcagcatgtc cacattggcc gcgcgggtgc ccggccagcg ccggtccacg
     7981 agcagccgcc agccccgctc gaccagcatc agcagctggg cggcgacccg ccgctccccc
     8041 tcactcgccg cctcccagcg ctcggcccgc gccctggcgg cctgccactg ttcccgtaac
     8101 agccgctcct gccgacgggc ctgctgcgcc cgccggcccg ccgacgcacc cgccgacccg
     8161 cccggtgcac tccctgccgc catcgctcgc cccctcaccg ctcgcccccg aaggcatggg
     8221 ccatgaacca catgggtcat gaaccatagg tcgatggcac atgacgcgga agtgcgcacg
     8281 ggcggggcac gggcgcatgg caggaagagt ccgcggggag gcgggtcacc cctgggactt
     8341 ggcgaactcc acgagcgcag cgaacccctg acgggtcagc gcgagctgcg gaccattcgg
     8401 atccttgctg tcacggacca ggaactcacc ggtggccgcc gcgtgctccg gagcccactc
     8461 gatgcactgt ccgccgttgt tgctgtacga ggacttggac cagcggaggg aatcggtcac
     8521 ggggtgccct ttcgtaagtc attgatcatg gccactgatg ccgcttggga gcgagcgtcg
     8581 gcctgtagct gatggtaggc cgtcagtatg ggcagcaccg aggtgctttc ccgttcaaga
     8641 tggccccgtt gggcggattc ggcgtaggac atgagtgagc ggtccggcag cgtcagcacc
     8701 gtaatcggca gatcgaatgg ccggcgctcc cccatgtcga acggggcgac gtggagcacg
     8761 gtgttcggca gttcggcgaa ctcgacgagc cgcgccaact gggcgtccat gacggcgggt
     8821 ccgccgatgg gccgacggat gcagctctcg tccagcacca cgaagatcag cggcgggcgc
     8881 gtccggacca gcgccgcctg tcgttccgcg atgagcgaca cccgttcgtc cgcctgctcg
     8941 ggcgtgatcg ctccgcgctt gacggcgctc ccagcaagca cggacgcgta ttccggggtc
     9001 tggagcagac cagggatgat gcccacttcg tacagccgga tctccgccgc ccggccctcg
     9061 tggccgacgt actcagggaa gccctccagc aggctgccgt gccggatctc gcgccactgc
     9121 cgttcgaacg tgtccacggt gccttcggtg ccgaaggtgc ggtcggcgct gcgcgaaaaa
     9181 cgcagagtag ggggtttccg cgcagtttcc accgccgaga cgtgcgtact ggaatatccc
     9241 atcagctcgg cgagctcgtc ctgcgtccag ccgcgcgcct cccgtgagct gcgcaggcgc
     9301 gccccgaagg cggcttgcgg actactgtcc ggcgtcaact ccttgcgatt cacagggctt
     9361 tcaccaacgc ttccccctcc ttcgacaggt tgaatgactc ccgaccctag gccactctgg
     9421 ccgcccttgg tagtggaatg actacggaga ggagcgggcg ttgagtggcc cagaggatgc
     9481 agcggtggac gtcggcttac cggaagacgc ggacccggag ggccccgaac gggccgatga
     9541 cagcgacagc gacagcgaca gcgacagcga cagcgagacc ctgacgcacc ttcgtgcgcg
     9601 agtgcaccag gactacgcgc ggcggcagcg ccacggacag ctggggaggt cgctatgagc
     9661 tgcacgacgt gcgacacctt gcgggccgtg ctggcggtgg ccgagcggca cggtgaccgg
     9721 tcgaaggccg tcgactgccg ggtgttgctg cggcggcacc cggaacacga cgacgtgccg
     9781 gtcgagggga aggccgagcg ggaggccgag aggaaggggg aaccgtgagg cccctggacg
     9841 cggagaaggc caccgcggac cccttcgcgg gcacgccgta cgaggcgagt cccgaggggt
     9901 ggtggacgaa gcacggtgga gcactggacg tggaatccgg cgtgatccac ctcccgaccg
     9961 gtcctggcct gccgccgtgc ctcgtcccgg aatgccggtg ctacccggcc ttcacggccg
    10021 accggaagag gccggccgcc gaggtgccca ggccggtcgg cgcacccaga cggcccggcg
    10081 aacccgtcgg atggcgcagc tcggaggccc ggtagcgccg gcagtcgcgg tgccagatga
    10141 ggatgccggc catccagtgc tccagctcgc ggacatagcc gtccaccgcc tcgcgcgcct
    10201 ccggcgagag ctggaaatcg tcgtagacga cggggagttc atgggccgcg acatgctgga
    10261 actcccgcat gcgcgaggtc atgaggtcgt cgacgatatg cagcgcggtc gggtagtcgc
    10321 agccgaagaa ggtctggacg acgaggatgc cgttgtggac ctctccctcg tattcgatct
    10381 ccttctggta cgagaagaca tcgttcatca ggccggcgta gtcggcggcg gcgttctcca
    10441 gtgagcgcag cgggccggag cggtagacct ccggcgggac ccgccggccg tgggcgagcc
    10501 ggctcaggct catggtgagg tcggcgccga acgtcgcccg gcgcatctcg atgtagtcga
    10561 ccgggtcggg gatgcggtgc tggatttggt tgccgatctc ccacagccag ctggcggtca
    10621 tggtgtcgac ggtttcgcgg aacgcccggc gcgcctcagg agccataccg gccgtcgtac
    10681 gggaccacag atccgccagc ccgcgttcga gggcgttgac cggctcgggt ggcgccgtcc
    10741 cggaatcgag cggcatgagg gccgacagcc gctcggtgca caccttcgcc gaggcgaggt
    10801 cgcgagtgcg gccgaagacc gccggatagt agtcgtcggc ataggtgccc caggccagcc
    10861 aggcggcgtc caggtccagc tgctccgggg tggcgtccgg gtggatgccc gccgcgcaca
    10921 gtgccagatc gtgccggacc atcgcgggct cgtcccagat gtcggagagc ggcacaccgg
    10981 gctgcggctg aaggaggccc atacggtgcg cccagtcgat gagccgcagc cgcgcgccct
    11041 ccaggtgcgg gctgagggtg gtggtgaacg gcatgcagaa ctcgggcagt tgggacggtc
    11101 cgaccgtctg gtgcgggagg tgggtgccgc tgcggaggcg gagcgcaccg gccgtggcca
    11161 gggcggtttt caggtccgcc gccgaggtgc cgaggccgcc gaaggagaag ggcgaccagg
    11221 gccgcgagct gtcggccgcc gccccgccgc cgttcatgta gcggctggag cgcatatgcc
    11281 attcgtggcc gccggactgc cagtcctgga gccccttggc gtaggccagc accttcgcgc
    11341 aggaggccgg atcgagcccc ttctccagga agagcggggg gagttcggcg aggaccgtgt
    11401 tctcgaactg ctgaagccgg gaggtgatca gatcgttgac cgcgtccgcc gcctcctggg
    11461 tggtgcagtc caggaaattc tccagtacca ggacgccatt gctcagctcg ccttcgtcct
    11521 ccgtctctcg ttgataggag aagagatcgt tccgcagatg gacggcgtcg gaaaaggtgt
    11581 cccgtagcac ccgcagtggc cgggacgcgg cgacggacgc gggcacctcg gcgccggtcg
    11641 catactccac caggcccgcc gaccagggcg cgccaccgac cttgcggcgc atctcgatgt
    11701 attcaacggg gttgggcacc cggtggatat tgatattgga caattcccac agagactcat
    11761 tgagcagatg ctcggtgctt tcggcgaacc gccgccgcca gtccatggac atctgcggca
    11821 ccgtgcgcat ccacaggtcg gcgagcccgg cctcgaccgg gttggccggc tccggaaggg
    11881 gcgcggccag gtccatcggc ataaaggcgg gcagccggtc cagatactcc ttgccgccct
    11941 tccggtccag cgtccgcttg aatttctcca ggaagtggtc gtcgaagaag aagacccaga
    12001 cataccagtc ggtcaccagc gaaagcgcgt cggcgtcgca ctccgggtgg gtgtaggaac
    12061 acagcagggc gtaatcgtgg gcgtcgagat ccttctcttc ccagatgccc gagccctcca
    12121 gcattcccag gtcgcgggcc cacttcctgg aatgcgtacg cgcggtctcc agatgcggat
    12181 tcaaccgcgc cggatggggc gtatagaaat ggggcaattc aaatggctga gtcaccgttg
    12241 ctggcctctt ccctgcgtac ggaaggaagg cgcggtggat cacgcccccc tgacggggct
    12301 gcgctacccc ggggcccggc gccttaggcc ttacggagga ggagcttctg cctccactcc
    12361 ccttcggttc ggagcgacac caactgggtt catttctcgc tgacttgtga cacttttctt
    12421 tcgtccgccc cgccggcccg gccgcgcgcc gcggtgcgca gggcgagcgc cgccagcgcc
    12481 tccggggcac cggcctggcc gcggataccg ggaaaggcat tgatgtccac gatgaggggc
    12541 gcaccgcccc cggcatcgag cagatccacc ccgtagacgt ccaggccgaa gacctcgccc
    12601 acctggagcg cggcggcggt ccagccggcg ggcagctcac cgaccggcag cggcaggttc
    12661 ggaccgcggc cgtcgggggc cagctccgag cggcgcagcg cggcgaagag ctgcccgtcg
    12721 accacccaca gcttgtggtc ccagccactg ttcggggtga agtcctggac caccaccggc
    12781 tcctcggccc agtcggcggc cagttcccgc agccgtacgg cgctgtcggc gcgggtcacc
    12841 aggtcccggc ggcggctgaa ccggctcttg atcaccagcg ggccgtccgg ggcaccggcc
    12901 gcggccagct cccccagggt ggccacggcg cgggtggccg cgaacggcag ccccgccgcg
    12961 cgcgccaccg ctgccatcgc cacccggtcc tggcaccggg cggtcgccgc cgccgagttg
    13021 agcaccggtg cgccgtgctc ctccaggagc gcggcgagcg ccagcgcccg gggcgtccgt
    13081 gccttgagga gatagacatc ggcgagcgcg gagaggtccg ggcccggccc tgcggcgccc
    13141 gggtccaggg tttcgacccg gtgatccggc gtcagcaggc cggtgaccgc ggccagcagc
    13201 ggatgcccgg ggtccgcggt gagcagacag atcctcaccg gccgccgccg atcgacgccg
    13261 cgggcctggt gggacggggc acgggcgacg cggtgaacgg gggcggcggg gcggccgccg
    13321 cgctcgtccg cgcggtggac ggcggggccg gggcaccggt ccggccggcc gcccgcgtgt
    13381 ccggtgcgtc ctcccgtacg gacgtctctc ccccgaacgc ctcccgcccc cgcgccccgt
    13441 tccgggccag gtccaggacc gcggcggaca cccgggcgac cgcgtccggc acctgacgga
    13501 agctggggaa gtcattgatg tcgacgacca ccgggccgtc cgggccgagc aggatgtcga
    13561 ccccgtagag gtcgaggccg aagacggcgc ctatctcggc ggtgatccgg gcgacttcgg
    13621 gcgtcagcgg cacctgccgt tcgcgtaccg cgtgtgcggg gtgcagcggg gagcaccgct
    13681 cggtcgcgta cagctcaccg gcgacgctgt agaccttcag atccgtaccg gagttgggga
    13741 catagggctg ggcgatcagc agccccccgg ccggtccgtc cgggccgccc ggctccagca
    13801 gccggtccgg cgtcgccacc agccgcacgg cgcgcccgga actgccgtcc gcgggcttca
    13861 ccacgagcgg gaactccgcc tcggctatct ccgcgaactc ctcgggacgg gccgccgcat
    13921 acgtcaccgg gaccggcagc cccttgctgc gggcgatcac cgcggccagc gccttgtccc
    13981 gtacgccacg gatggcccgg acgtcgttca ccgtggtcag cccgacggaa gcggccgctt
    14041 ccaggagcgt caggcccgga ccgccggaga cggtcttgag gacccaggca tcgtggctgc
    14101 cggcccggat cgcctcggat atccggatca gcgagcggcc gggccacacc acgtccacct
    14161 ggtggtccca ggcgcggagt tggtggatca cctccagcgg catgccgtca tggcggtact
    14221 gctcctccac caggaagcag agtctcatcg ggcaccctcg tcatcgccgc acgtccaccg
    14281 accgtccggc agatccatga cataccagga tcccatgcgc ggctcgccgg ggtcggtgca
    14341 cccacgcacc gggccccggc tcgcccacgg gcgcacccga cgggccgccc ctgcccgact
    14401 ccgacgccta cgcctacgcc tacgccagga acgccgtggt ggccgccgcg aagcgcccgg
    14461 gatcgtcgag ccacgggaag tgcccggcgc cgggctgaac gacgaggcgg gcgtgcggga
    14521 acaggtcggt gaactccgcc atcgcaggcg gcggggcgcc caggtctacc tcaccggcga
    14581 gcagcagcac cggccgcccg aaggcggcga gcgccgcgcg ggtggcctcc gggtcgaagg
    14641 caccttcggc gccgaagaca gccgcggccg ccgcgttccg ctggccgtcc tccgcggccc
    14701 ggtgcgactg cgccgccgcg tcccaacgcc cgtagaagaa cggcgcaatg cgctctcggc
    14761 agtcgtccgc cggcttgccc gcgacgagcg cctccaaggc cgcgaacgcg ggggcgaacc
    14821 acggctcctc gtggcggagc cgcgcggtct cgcgccggag gtctccggtg atgacgagcc
    14881 cgacggccag cacactgggc gtgatcagcg ccatcttgcc gacacggtcg gggtggcggc
    14941 ccgcgtacag caccgcgaga ttcgcgccgg cactgtgcgc gagcagatcg acgctttcca
    15001 ggccgaggtg ctcgcgcaac gcctccacat cgtcgacgag ccggtcgcag cggtaggagg
    15061 ccgggtccgc cggtatcgcg gagccgccgg taccccgcag atccagcctg atcagccggt
    15121 ggtgcgcggc cagaccgccg aggtcgccga ggtatgcgga atcctgcatc ggtccccccg
    15181 gcaggcagat cagcgggggt ccgtctccgg acacgtggta ggcgagcgtg gttccgtcat
    15241 gcgcggagaa ggtgggcatg gcggcgacct tgtcagcggc gtccgtgcgg agcaactggt
    15301 ttccgctgcc cgcacgtcgg acggcaaggc caccgcccgg ccgccggaaa ccgcccggtc
    15361 gtcccacgcc gccggaccgt cccgctccgc ccaccggagc ggccccgtcc acctccgctc
    15421 ccggtgtcgc taccgtgagg cgacgcaacg gagcaggacc gggatggacc gggagcaatc
    15481 gggaggccca gtgacccaca aggccgtgcc cttcgacgac ctcgaccgca agatcgttgc
    15541 ggcgctgatc gacaacggcc gggcgagctt cgcggagatc gggacggcga tcgggctgtc
    15601 gtccaccgcg gtgaagcggc gagtggaccg gatgcgggag aacaacgtga tcacggggtt
    15661 caccgccacc gtccgcccgg ccgcgctggg ctggctgacc gaggcgtatg tcgaggtgta
    15721 ctgcgacagc gcggcgccgc cccgccggct cgcggaggtg gtgcgcaacc acccggagat
    15781 cgcggcggcg atgacggtca ccgggggcgc ggatgcgctg ctgcacgtcc gggcgaccga
    15841 tgtggagcac ttcgaggagg tgctcgaacg catccggacc gagccgttca tccgcaagac
    15901 gatcagttac atggtgctgt cccatctgct gccggacagc ccggaggcgg gcgcccggca
    15961 gtcctccgaa gggaccgtcc gctgaggcgc ccggtgcgcg cggcccgtca cagccgccgc
    16021 aggcccgggc caccggccgc acaagcggaa tccgggacga gagcgcgcag caaagctgcg
    16081 tgagcgcgcg catacacgca gcattactgc gccgctcagc agcatttgtt tcttgtggcc
    16141 cgaatccctc gctccttacc ttggaagcat tcggggtgac gctctgtgac ccctggtcac
    16201 cccgcattgc ccgaggagcg aagggatcgt cccgtgccga tgagtcgtgt gtcgcgcccc
    16261 cggcgctatc tggtctgcga gcccagacac ttcgccgtgc attacgcgat caacccatgg
    16321 atgcgggccg acgtgcccgt ggacaccgcg ctcgcggggc gccagtggga gacgctgatg
    16381 ggcacctacc gcgcccatgg gcacaccgtg gagacggtgc ccccggtgcc cggcctgccg
    16441 gacatggtgt tcgcggcgaa ctccgcgctg gtcgtgggcg gccgggtctt cggctcgcac
    16501 ttccacgccc cgcagcggcg gccggagtcc acggagtacg agacctggtt caaggcggcc
    16561 ggctacgacg tctaccggcc ggagtcaccg tgcgagggcg agggcgatct cgtcccggcc
    16621 ggccgcttca tcctggccgg caccggcttt cgcaccaccc cggcggcgca ccgcgaggtg
    16681 caggagttct tcggcatgcc gacgatcggc ctccagctgg tggacccgta cttctaccac
    16741 ctggacaccg cgctcttcgt gctcgacgaa tcgccggaga cgggcgaggc gcatatcgcc
    16801 tactaccccg aggcgttctc gtccggcagc cgtgaggtgc tgcggcggct gttccccgac
    16861 gcggtgctcg ccacccggga ggacgccatg gccttcggcc tcaactccgt ctccgacggc
    16921 cgccatgtct tcgtcgcccc gcaggcgacc ggcctgatcg ctcagctcag cgcgcacggc
    16981 tatgtccccg tccccgtcga cctgtcggag ttccacaagg ccggcggcgg catcaagtgc
    17041 tgcacccagg agatccgctc atgaccgctc ccacccgtac cgtcccggcc caggctcccc
    17101 gttcgtccgc ggagctcatc caggccgaga gcccggtgct cgcgcacaac taccacccgc
    17161 ttcccgtggt ggtcgcgcgc gccgaagggg tctgggtcga ggacgtcgag gggcgccgct
    17221 acctcgacat gctggccggc tattcggcgc tcaacttcgg ccatcgccat ccggccctga
    17281 tcgaggccgc gcaccgtcag ctcgaccagc tcaccctcac ctcgcgggcg ttccacaacg
    17341 accggctcgc cggtttcgcc gagggcctcg ccgagctgac cggcctggac atggtgctgc
    17401 cgatgaacac cggcgccgag gcggtggaga gcggcatcaa ggtggcccgc aagtgggcgt
    17461 acgacgtcaa gggcgtcccg gcggaccgcg cgacgatcgt ggtggcgggc ggtaacttcc
    17521 acggccggac gaccaccatc gtcggcttct ccgacgacga caccgcccgg gtcggcttcg
    17581 gccccttcgc ccccggcttc cgcaccgtcc cctacaacga cctcgccgcg ctggaggcgg
    17641 ccctggacga gacgacggcc gccgtgctga tcgagcccat ccagggcgag gcgggcgtcc
    17701 tgatccccga cgacggctac ctcaccggcg tacgcgaact gacccggcgc aacggctgtc
    17761 tgttcatcgc cgacgagatc cagtccgggc tgggccgcac cggcaccacc ctcgcggtcg
    17821 agcacgagtc cgtggtgccg gacatgctgc tgctcggcaa ggcgctcggc ggcggcatcg
    17881 tcccggtctc cgcggtcgtc gcccgccgcg aggtgctcgg cgtgctcggc cccggccagc
    17941 acggctcgac cttcggcggc aacccgctgg cggcggcggt cggttcggcc gtgatcgagc
    18001 tgctcgccac cggcgagttc cagcgccgcg ccgccgaact cggtgccgta ctccgcgacg
    18061 gcctggccgc gctgaccggc aagggcgtga ccggcttccg ggcccgcggc ctgtgggccg
    18121 gtgtcgacat cgaccccgcc ctgggcaccg gccgggagat cagcgaacgc ctgctgaagg
    18181 aaggtgtgct ggtcaaggac acccatggct cgacgatccg gctggccccg ccgctgacca
    18241 tcaccgacgg ggaactgacg tcggccctgg gcagcctgga gcgggcgctg ggctgacccg
    18301 gcacccggct cagttcggca cgcacggagc ggccgcggct cgtccgagcc gcggccgctc
    18361 cgcgtcctgg gccgttgccc gtgcgtccgg cccctgtggc ccctagaagg agccgttacg
    18421 gttgcggatg tcgatgcacg ccttgtgcga gctgcccttg aaccgcacgc agagattccc
    18481 gtcggactgg atgcccggga cggtgtggcc gacgatctcg ccgccggacc gcttcgcctt
    18541 gaacgagtag gtgtaaccgt ccggctggta gaggtagacg gtcgcggact tccggctctt
    18601 gggcgggttg gtccaggaag cggtgacgtg accggggttg gccgtcccgt tctggccgtc
    18661 ggccgcgatg cagatctgcg gacccgacca gtcatgggtg caggcgtccg cggcggcgtg
    18721 cgcggccggg gtggtggcga cggcgctcag cgcgatcgtt ccggcgacgg tcagggcgcg
    18781 gagcagcttc gaacgggtca tgtgtggggg gagtcctctc ctcggagtac gggcgaagac
    18841 gcgaaaaatc ccgccacgaa tggggcgtgg cgggcaccgc gtgcacgtag ttgatcttag
    18901 tcgatattcg aactcacgtg ccctcaattt cccttgtgcg gcaccccgtt cgcaccgcca
    18961 caccccgccg cctcgatgag cacggcggcc gcggtacggg cctgccgggc ggcgccgggc
    19021 tcacccatca gcgcggcccc ggcgatcgcc ccgtcgatca gcagcaccaa ctgccgtgcc
    19081 aacgcctccg gttcggccac cggcaccgcc cgcaccagac cggtcacata cgccagcagc
    19141 gcctccttgt gctcccgcgc gacccggccg acccggtcgg aggtcgcccc cagctccccg
    19201 cacgcgttga ggaaggcgca gccgcggaag ccgtcctccg cgaaccactc gcccagccag
    19261 tcgaagaccg cgagcggccg gcccgcgggg ccgtcggcgt gcgcgtcgac gtactcggcg
    19321 agtgcggtgc gccagcgggt gtcgcgccgg cgcaggtagg tctcgacgag gtcgtgcttg
    19381 gcggggaagc actggtagag gcgcttgagc gacacccctg cggcggtgcg gagttcatcc
    19441 atccccacgg actggatgcc gcggtcgtag aacagcttct ccgcggcgtc gagtatccgc
    19501 gtacgggctt cgtcgaggtc catggcactt ccggggcttt ccaggagaac ggtcgttctc
    19561 tacactagcc gaccaagaga gaacgatcgt tctccgctct tgagaaaggg agtccgccat
    19621 ggcgccacgc gcacccttcc ccccgttcga cgagccgggc gcacggcaga aggtgcaggc
    19681 ggccgaggac gcctggaaca cccgcgaccc ggagcgggtc gccctcgcct acaccgagga
    19741 ctcggtctgg cggaaccgcg acaccttcct caccggccgc gacgagatcg tcgccttcct
    19801 gcgccggaag tgggcccggg agctggacta cgccctgcgc aaggagctct ggtcgtacag
    19861 cggcaaccgg atcgcggtgc gcttccagta cgagtgccat gacgcggccg ggcagtggtg
    19921 gcgcagctac ggcaacgagc tgtgggagtt cgacgcggac gggctgatgc gccgccggga
    19981 ggcaggaatc cacgacgtcg cgatcacgga ggcggaccgg cgcatcttcg gaccacgggc
    20041 ggaggaggag cgtggccacc cgcttccgtt ccgctgaccg cccggcgccg gacaactccc
    20101 cctgggtaaa ggctgggaga agccgcgaaa cgtagacaag gcggaggttt cgccgcccct
    20161 cggcgtggga agcaaggaat cgaccgacca atgggctgcc catccctcct cggggatgcg
    20221 cggcccatcg cttttttgcg acgtcgggcc tgtggttgtg gcgccccgga gcgggatctc
    20281 cggacggccc cccacagaag gggtccacat gagcacgaat ctcttggcac cggcgcagac
    20341 tctgctggag ccggccacct cgcccggccc ggtgcgggca acggcggcgc ccgtgacgtt
    20401 cctggccgtc acgacgatcc cggtcggcag caacccggtc gggctggcgt tcatccccaa
    20461 cggcgacctc tacgtcgcca actccgggtc gagcaatgtg cagaccatcg acaccgccac
    20521 ggacaccgtc atcggcgccg cgatccccac cggcaccaca ccggcctggc tgaccgtcgc
    20581 tcccaacggc aacgcctacg tccccaacaa catctccaac aacgtgacgg tgatcgacac
    20641 cgccaccagc accgtcctca ccacgatcgc gctcagcggc gggcccgccg cggcggcggt
    20701 catccccagc ggcaacgtct acgtgagccg cttcggggcg aacagcgtgc aggagatctc
    20761 caccgccacc aacaccaccg tcggcgccgc gatccccacc ggcagcggcc cggtcgggat
    20821 cgcggtcgcc cccaacggca aggcctatgt cgccaaccgg aacggcaaca gcgtgacggt
    20881 gatcgacacc aacaccgcca ccgtcgtcac cacgatcccc ggcttcaatc agccgaactt
    20941 cgtggcgatc ggccccagcg gggacgccta cgtcgccaac atcgggtcga acaacgtgtc
    21001 cgtgatcgac acgaccacgg acacgatcgc gaccacgatc cccgtcggca ccaacccgtg
    21061 gggcatcacg gtcggccccg acggcaacgc ctacacggcc aaccgcggct cgaacaacgt
    21121 gtcggtgatc gacaccacca ccaacaccac catcggcgcc ccgatccccg tcggcagcca
    21181 gccgatcgcc ctggtggtcg cgcccaacaa caaggtctac gtcaccaaca tcgccggggc
    21241 cagtgtcagc gtcatccagt tcgacccgac gatcagcagc atcaccccca actcggggcc
    21301 cgtcacgggc ggcacggtgg tgacgatcac cggcaccaac ctgaccgggg cgagcgtcga
    21361 catcggcggc aaccccgcga ccggcgtgac cgtcaacgcc accggtacgc agctcaccgc
    21421 gaccactccg cccggagtgc cggggcccgc ggacgtcacc gtcaccaccc ctggcggcag
    21481 caccactctg gtgggcggct tcacctactt cgtccccgtc cacgccacct cgctgaccgc
    21541 gaccccggcg ctgacgaagc tgttcccgcc gcacgtgtac ttcccgttcc tgacggccac
    21601 gctgaccgac caggtcaccg gccttccggt gcccaaccag ccgatcctgt tcaaggccgg
    21661 cagcaacgtc ctgggcatcg ccaacaccga cgcccaaggc gtcgcccggg tgaacgagac
    21721 gctcaccctg acgctcatcc tcctcaacgg cggctacgag gtcagcttcg ccggcgcggc
    21781 caccccgacg gccatcctgt cgccgtccag cgacacggca ccggtcatcg agccctgatc
    21841 ccgccagttc accggcctga ccacccagcg gcacctacgg gagcgccccc cgtacgtgcc
    21901 caccgccggc cccccggaac cggacggcca ggctccagaa gttcccccgg tcgatttacc
    21961 caactccttg gcagggaagg gcagtcggcg tatcttggaa tgaccgttcc aagatacgtg
    22021 agcgggaccg agcgaccctg cgttccttcc tccggtgacg gcgaaacgag cagcacagcc
    22081 atgcccgaca tcaagcactt caaccccgag atcgtgctcg acgaagcgat ccaggtcttc
    22141 tggcggcacg ggctgccgac gaccggcatc caggcgctgg tcagcgcgac cggagtgagc
    22201 cgctccagcc tctatgcgac cttcggcaac aagga
//
