LOCUS       NZ_CDME01000015        10351 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Kibdelosporangium sp. MJ126-NF4, whole genome shotgun sequence.
ACCESSION   NZ_CDME01000015
VERSION     NZ_CDME01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium sp. MJ126-NF4
  ORGANISM  Kibdelosporangium sp. MJ126-NF4
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-NOV-2014) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000826545.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:10:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,648
            CDSs (total)                      :: 10,573
            Genes (coding)                    :: 10,470
            CDSs (with protein)               :: 10,470
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 19 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 5 of 103
            Pseudo Genes (multiple problems)  :: 10 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 216017
            Orig. end                         :: 226368
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CDME01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10351
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="2"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10351
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10351
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5351](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(564..578)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            1051..2421
                     /locus_tag="BN1199_RS43285"
     CDS             1051..2421
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BN1199_RS43285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_042195201.1"
                     /transl_table=11
                     /translation="MTTNPNVDAPTASAAPARAQPSARSVGLRLGALFGPVVFGVTAAG
                     VALPDVARELQVTPAAVAWVITAHAVALGVGTALFGRLADALGVRTALLTGAVVILAGT
                     VVCVVSPNLGVLVAGRFLLAAGSGAMASCALTLVASRDPATRPAVLAGFGATMAVFSAS
                     ATLMGGVVTQWLTWRLTVVLPVLSVLVIPFCLVLATRPGSRRPVDAPGAAVLTLTVSAL
                     VVLIQSPSLSLPAWLVVAAAAVVLAGASVLAVRVRSLPTGFLPRALLTDRTYLLAAVVG
                     IGVYGGLFASMWAVPQVLAKQYGWSVLVIGLALLPGAVIGAVLSRLAGLLTSGNGGAKL
                     LTGAAVTSALCLAGAGILGGGWLLLVGGASLGFAAFAVTQVVTTGVMSVRIPPERRGGA
                     LGILNMSFFVGGGVGTAIAGGLSKAMPMTGALAVVAVLPLVSGLLALVLSKRAAQSA"
     gene            2561..3607
                     /locus_tag="BN1199_RS43290"
     CDS             2561..3607
                     /NRPS_PKS="Domain: AMP-binding (79-295). E-value: 2.7e-08.
                     Score: 24.7. Matches aSDomain:
                     nrpspksdomains_BN1199_RS43290_AMP-binding.1"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1199_RS43290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="phenazine biosynthesis protein"
                     /protein_id="WP_042195203.1"
                     /transl_table=11
                     /translation="MSSVFDSQVRKLTHWHFSPETGSPFWLGMRDRLDFDPVADVHSAA
                     DLSRFPDVSEQLRQVPATALIPRGLAQETFRVYDSGGTTGSPKRIVDNAYRTRLTTWAW
                     QRLQEVGIPATGNWLHLGPSGPHVICFDVSRYAAQAGGVFYTVDLDPRWVKHMIATDRP
                     ELAAEYVEHILDQAETILRTQDIAVLNTTPPLLEAICARPELYDLVRSKVHAIIWAGTS
                     ISSENLRQLDEVFFPEAAIVGVYGNSLMGVAPQRPAADSDTYKCVFEPFGDTTQLDLVD
                     DSGSIVEYGQRGRVRLNLVTDEMFLPNILERDTAVRIPPRPGSEVDGLADVQTYRALGD
                     VRIIEGVY"
     aSDomain        2798..3445
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN1199_RS43290_AMP-binding.1"
                     /evalue="2.70E-08"
                     /label="BN1199_RS43290_AMP-binding.1"
                     /locus_tag="BN1199_RS43290"
                     /protein_end="295"
                     /protein_start="79"
                     /score="24.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SGGTTGSPKRIVDNAYRTRLTTWAWQRLQEVGIPATGNWLHLGPS
                     GPHVICFDVSRYAAQAGGVFYTVDLDPRWVKHMIATDRPELAAEYVEHILDQAETILRT
                     QDIAVLNTTPPLLEAICARPELYDLVRSKVHAIIWAGTSISSENLRQLDEVFFPEAAIV
                     GVYGNSLMGVAPQRPAADSDTYKCVFEPFGDTTQLDLVDDSGSIVEYGQRGRV"
     gene            3607..4977
                     /locus_tag="BN1199_RS43295"
     CDS             3607..4977
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012398.4"
                     /locus_tag="BN1199_RS43295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_042195204.1"
                     /sec_met_domain="Aldedh (E-value: 1.5e-10, bitscore: 36.1,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTVVAVDPIIGGKDARSSDRSVLYSVLGAPLADIGMAPRLQAQA
                     ALNQIRADADGVPPDSSIFSTAAQLFADSTVDGQSADEYTASVTASTGLTAATVRQAVR
                     ELVEEIEDLPASTRANLPDTDLGNGFRTRWVARGRVFAGVMASNHPGPNVSWVRALFHG
                     YSVIIRPGSRDPFTPLRLIAALTQAGLPANRIAFLPCAHEVGTFLLRQADRGIIYGGER
                     AVRTWRQDDTVAVRGPGSTKALLDSALTDELVRHLVASASFDGGTRCTNLSALLTSESP
                     AEVADVLAERLSSLPVLPADDPTARLLVVDRKRADQLRTQTADLRHTLNDHSARYDEHD
                     PVVELPDGSFLPRPLVLSADRADHPAVGTELPFPFLVVAPWTPQDGIAPLRGSLVLNLM
                     TQRTDIVDAAVREPSVRKVTMGPVLPWTAVPGIPHDDNYTQFLLEPKGIVDADAIGA"
     misc_feature    3727..3729
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5001..5351
                     /locus_tag="BN1199_RS56735"
     CDS             5001..5351
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017995.4"
                     /locus_tag="BN1199_RS56735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_052479057.1"
                     /sec_met_domain="melC (E-value: 2.9e-28, bitscore: 94.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIDRRDALKIGVMAAASMAAVGTAGVLGAQAIADGGEDSQAHAE
                     KYKGRDISVSEVNGEPVAHIDGVPLHLMKLGDDAYMSALCHYEIVDSPLVAARRAVDEL
                     RGANLLAIAHHV"
     gene            5363..6283
                     /gene="griF"
                     /locus_tag="BN1199_RS43305"
     CDS             5363..6283
                     /EC_number="1.10.3.15"
                     /codon_start=1
                     /gene="griF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020674092.1"
                     /locus_tag="BN1199_RS43305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="grixazone synthase"
                     /protein_id="WP_042195205.1"
                     /transl_table=11
                     /translation="MVHIRKNHLDMTADEKRRFINAVLEIKRRGIYDKFVALHIKVNSR
                     DYIDKESGKRLGHVNPAFLPWHRQYLMRFENELRKVDHRVTLPYWDWTIDHGENSPLWA
                     EEFMGGNGRPGDRRVMTGPFARDNGWRLNISVIPYGPENPALNGHYTTDDRDYLVRDFG
                     TLTPNLPTPAELEQTLALKVYDCPPWNHTSGGVPPYDSFRNHLEGYTKFEWEPRLGKLH
                     GAAHVWTGGHMMYIGSPNDPVFFLNHCFIDKCWAMWAERNPEVPHYLPLVDTKDVPDID
                     TKLGPWHTMTPHDLIDHKKWYHYDS"
     gene            7423..7848
                     /locus_tag="BN1199_RS43310"
     CDS             7423..7848
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1199_RS43310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157529129.1"
                     /transl_table=11
                     /translation="MRRVWLGITVLAVFVLPSCGNPPDGGQPVTSTDSHAPAPVAPTTA
                     QSELHKHLVDLKLLVASGPCAPQECVQRAQSILARSVAIRRTILDSPDRGRLRPAVDIV
                     DRLAGISADQAGDPGIQRQIVEVGVELVDWLGRNVTW"
     misc_feature    8068..8081
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
ORIGIN
        1 ggtcatcgac gcggccgcgc cgcacggcct ggcgccgctc aacgggtcct caccgctggt
       61 cggtgtcgtc ggttacaccc tcggcggcgg actgggcgtg ctggggcgca aatacgggta
      121 cgccgccgac aacgtcgact cggtcgaggt cgtcacgaca agcggtgcgt cactgcgtgc
      181 cgcgccgtcg gagcacgagg acctgttctg ggcgatccgc ggtggcaagg gcaacttcgg
      241 tgtcgtcacg tcgatggaga tcgccctggt ccccgtcgaa cgactctacg gcggcgggtt
      301 gtacttcccc gcgtcgaagg ccgggctggc gctgcacgcg tggcgtgagt gggtcgagac
      361 cgtgccggag gagatgacgt cgtcgctggt gttgctgcgg ctgcccgaca ttcccgacgt
      421 gcccgagttc ctgcgcggcc gtctggttgt gcacgtacgg atctcgttca ccggaagcga
      481 ggaggccggt cgggagttgt tgcgcccgtt gcgtgccttg cggcccgaac gcgacacggt
      541 ggcgatgatg ccgtacacct cgatggccga gatccaccac gacccggtcc atcccctgcc
      601 gtaccacgag cgctgcactg tgctgcgtga gttcgaccgg caggccgcgg acacgctgat
      661 cgaactggcc gggccgtatt ccggctggca ggacgtgatg gtcgaactgc ggcacctcgg
      721 cggcgcgctg ggcaggccgc ccgccgtgcc gaacgccgtc ggccaccgcg acgccgcgtt
      781 caccctgtcc accatcagtg ttcccgacca cgacgagcct gtcctgccgc tggtcgaccg
      841 gatggccagg tggtcgaccg gactgcggta tctcaacttc ctcggcgggc ccagcacagc
      901 gcaccagacc caggacgcct tcgacgcggt gacctatcgc aggctcgcga tggtcaaggc
      961 cacgtacgac ccggcgaacc tgttgcgtgt caaccacaac atccttccgg cggtcgcacc
     1021 gcacacggac cggcagatcg aggagtcggc atgacaacga atccgaacgt cgacgcaccc
     1081 accgcgtcgg cggcgcccgc gcgggcgcaa ccaagcgcac ggtcggtcgg gctgcggctc
     1141 ggtgcgctgt tcggcccggt ggtcttcggg gtgacggccg cgggcgtcgc cctgccggac
     1201 gtcgctcgtg aactacaggt cacaccggcc gcggtggcct gggtgatcac cgcgcacgcg
     1261 gtggctctcg gcgtcggcac agcgctgttc ggcaggctcg ccgacgccct gggcgtgcga
     1321 accgcgctgc tgaccggcgc ggtggtgatc ctcgcgggca cagttgtctg cgtggtgtcg
     1381 ccgaacctgg gtgtgctggt ggcaggccgg ttcctgctcg cggcgggctc cggggcgatg
     1441 gcgtcgtgcg cactgacgtt ggtggcgtcc cgtgatcccg ccacacgacc cgctgtcctc
     1501 gccgggttcg gcgccaccat ggcggtgttc tcggccagtg ccacgctgat gggcggtgtg
     1561 gtgacgcagt ggctgacctg gcgcctgacg gttgtgctgc ccgtgctgtc ggttctggtc
     1621 atcccgttct gcctggtgtt ggccactcgg cccggttccc gacggccggt cgacgcgccc
     1681 ggcgccgccg tgctcacgct cacggtgagc gcgttggtcg tgttgatcca gtccccgtcg
     1741 ttgtcgttgc ctgcctggct ggtcgtcgcg gccgccgctg tggtgcttgc cggtgcgtcg
     1801 gtgctggcgg tccgtgtccg gtcgctgccc accggtttcc tgccgcgggc gctgctcacc
     1861 gaccggacgt acctgctcgc cgccgtggtc gggatcgggg tgtacggcgg gctgttcgcg
     1921 tcgatgtggg cagtcccgca ggtgctggcc aagcagtacg gctggtctgt gctggtgatc
     1981 gggttggcgc tgttgcccgg tgcggtcatc ggcgctgtgc tgtcccggtt ggccggtctg
     2041 ctcacctcgg gcaacggcgg cgccaagctg ctgaccggtg ccgctgtcac gtccgcgctc
     2101 tgccttgccg gtgcggggat tctgggcggt gggtggttgc tgctggtcgg cggcgcgtcc
     2161 ctcggcttcg ccgcgttcgc cgtgacacag gtggtgacga ccggcgtgat gtccgtgcgc
     2221 atcccaccgg agcggcgcgg tggcgcgctg ggcatcctga acatgagctt cttcgtcggc
     2281 ggtggtgtcg gcacggccat cgcgggcggg ctgtccaagg cgatgccgat gaccggggcg
     2341 ctggccgtgg tcgccgtgct gccgttggtg tccggtctgc tcgcactcgt actgtccaaa
     2401 agggcagcac agtccgcctg aacagttcgc ccgaaaaggc cccggctcgc gccggggcct
     2461 tttgcttgcg cgggaataca tccgcgatat ccccgcgata cgcggcgggc acaggatggc
     2521 gggggcaacc ggtcaaacca gggggaaggc aggtcactcg atgagttccg tgttcgacag
     2581 ccaggtgcgc aagctgacgc actggcattt ctcaccggaa acggggtcac cgttctggct
     2641 cggaatgcgg gaccggctgg acttcgaccc ggtcgccgac gtgcacagcg cggcggacct
     2701 gagccggttc cctgatgtga gcgaacagct gcgccaggtc ccggcgacgg cactgatccc
     2761 acgcgggctc gcgcaggaga cgttccgcgt ctacgactcc ggtggcacga ccggatcccc
     2821 gaaacgcatc gtcgacaacg cctaccgcac caggctcacc acgtgggcgt ggcagcggct
     2881 gcaggaggtc ggcattccgg caacgggcaa ctggctgcac ctggggccga gcgggccgca
     2941 cgtgatctgc ttcgacgtct cccgctacgc cgcacaggcc ggtggcgtgt tctacacagt
     3001 cgacctggat ccccggtggg tcaagcacat gatcgccacc gaccggccgg agctggccgc
     3061 cgagtacgtc gagcacatcc tcgaccaggc cgagaccatc ctgcgcacgc aggacatcgc
     3121 ggtgctgaac acgacaccgc cgttgctgga ggcgatctgc gcacggcccg agctgtacga
     3181 cctcgtccgg tcgaaggtcc acgcgatcat ctgggcggga acgtcgatca gctcggagaa
     3241 cctgcggcag ctcgacgagg tcttcttccc ggaggccgcg atcgtcggcg tctacggcaa
     3301 cagcctgatg ggcgtggcac cgcagcgtcc cgccgccgac tccgacacct acaagtgcgt
     3361 gttcgagccg ttcggtgaca cgacccagct cgatctggtc gacgacagcg gatccattgt
     3421 ggagtacggg caacgtggcc gggtccggct gaacctggtg accgacgaga tgttcctgcc
     3481 gaacatcctc gaacgggaca ccgccgtgcg catcccgcca cgaccgggct ccgaggtcga
     3541 cggactcgct gacgtgcaga cctaccgcgc gctcggtgac gtccggatca tcgaaggtgt
     3601 ctactgatgg gcacggttgt cgccgtcgac ccgatcatcg gcggtaagga cgcgcgcagc
     3661 tcggaccgtt ccgtcctgta cagcgtgctc ggcgccccac tcgcggacat cggtatggcg
     3721 ccacggttac aggcgcaggc ggcgctcaac cagatcaggg cggacgcgga cggcgtacca
     3781 ccggactcat cgatcttcag caccgcggcc cagctgttcg cggactccac tgtggatggc
     3841 cagtcggccg acgagtacac ggcgagcgtg accgcgtcca ccgggctcac cgcggccact
     3901 gtccggcagg cagtgcggga gctggtcgag gagatcgagg atctgcccgc gagcacacgg
     3961 gccaacctgc cggacacgga tctgggcaat gggttccgca cccgctgggt ggcgcgcggc
     4021 cgggtcttcg ccggagtgat ggccagcaac caccccggcc cgaacgtgtc gtgggtgcgg
     4081 gcattgttcc acggctacag cgtcatcatc cggccgggca gccgggatcc gttcaccccc
     4141 ttgcggttga tcgccgcgct cacccaggcg ggcctgcccg cgaaccggat cgcattcctg
     4201 ccgtgcgcac acgaggtggg caccttcctg ctgcggcaag ctgatcgagg catcatctac
     4261 ggcggcgagc gcgccgtgcg gacgtggcgt caggatgaca cggtcgccgt ccgagggccg
     4321 gggagcacga aggcactgct ggattcggcg ttgaccgacg aactggtccg gcacctggtc
     4381 gcgtccgcgt ccttcgacgg cggaacgcgg tgcacgaacc tgtcggcgct gctcaccagc
     4441 gagtcacccg ccgaggtcgc cgacgtgctg gccgagcggc tgagctcgtt gccggtcctg
     4501 cccgcggacg atcccaccgc gcggctgctc gtggtcgacc gcaaacgcgc cgaccagttg
     4561 cgcacccaga cagcggacct gcggcacaca ctgaacgacc actccgcacg gtacgacgaa
     4621 cacgatcccg tggtcgaact cccggacggc tcgttcctgc cacgcccatt ggtgttgtcc
     4681 gccgaccggg ccgaccatcc cgcggtcgga acggaactgc cgttcccgtt cctggtcgtc
     4741 gccccgtgga cgccgcagga cgggatcgcg ccgctgcgcg ggtcgctggt gctgaacctg
     4801 atgacgcagc ggaccgacat cgtcgacgcc gccgtgcggg agcccagcgt gcgcaaggtg
     4861 accatgggcc cggtcctgcc atggaccgcg gtcccgggaa tcccccacga cgacaactac
     4921 acgcagttcc tgctcgaacc caagggaatc gtcgacgcgg acgcgatcgg cgcgtgatga
     4981 cagcgaagga aggtactggg gtgtcaatcg accggcgcga cgcgctcaag atcggtgtga
     5041 tggccgcagc cagcatggcc gcggtcggca cagcaggtgt actcggcgca caggccatcg
     5101 cggatggtgg cgaggacagc caagcacacg cggagaagta caagggacgt gacatcagcg
     5161 tcagcgaggt caacggcgaa ccggtcgcac acatcgacgg cgtgccactg cacctgatga
     5221 agctgggcga cgacgcctac atgagcgcgt tgtgccacta cgagatcgtg gacagccccc
     5281 tggtcgccgc ccgccgagct gtcgacgagc tgcgcggcgc caacctgctc gccatcgcac
     5341 accacgtctg agggaaacca ccatggtcca catccgcaag aaccacctcg acatgaccgc
     5401 cgacgagaaa cggcggttca tcaacgcggt actggagatc aaacgcaggg gcatctacga
     5461 caagttcgtc gcgctgcaca tcaaggtgaa ctcacgcgac tacatcgaca aggagagcgg
     5521 caaacgactc gggcacgtca acccggcgtt cctgccgtgg caccgccagt acctgatgcg
     5581 gttcgagaac gaactgcgca aggtggacca cagggtcacg ttgccctact gggactggac
     5641 catcgaccac ggcgagaact caccactgtg ggcagaggag ttcatgggcg gcaacggccg
     5701 ccccggtgac cgtcgagtga tgaccggccc attcgcacgg gacaacggct ggcggctcaa
     5761 tatcagcgtg atcccgtacg gcccggagaa cccagcgctc aacggccact acaccaccga
     5821 cgaccgcgac tacctggtcc gcgacttcgg cacactgacg ccgaacctgc cgacaccggc
     5881 agaactggaa cagacgctgg cgctgaaggt gtacgactgt ccaccatgga atcacacgtc
     5941 gggtggcgtt ccgccgtacg acagcttccg caaccacctt gagggataca ccaagttcga
     6001 gtgggagccc cgactcggca agctgcacgg cgcagcacac gtgtggaccg gcggacacat
     6061 gatgtacatc ggctcaccca acgacccggt gttcttcctc aaccactgct tcatcgacaa
     6121 gtgctgggcg atgtgggccg agcgcaatcc ggaagtgcca cactaccttc ccctggtcga
     6181 caccaaggac gttccggaca tcgacacgaa actgggaccg tggcacacga tgacgccaca
     6241 cgacctcatc gatcacaaga agtggtacca ctacgatagc tgacccaccg gggccaggca
     6301 ggttccgtcg aagtcgggct tggcgcgcaa agcgagcaca tgagggcacg cgcgcaaagg
     6361 gcctcgcgcg caagacgcca cgcgcgcaag aggccttgcg cgtaagtggg caagcgggcg
     6421 agaggccttg cgcgcaagcg catgggtggg cgagaggcct tgcgcgcaag cgcatgggtg
     6481 ggcgagaggc cttgcgcgcg agcgcatggg tgggtttcgt ggttggtttc ctcccgtatg
     6541 gcctgggcga agccatacca cggcgtgtcg ggaggtcggc ctacgaaact ggcgtgccca
     6601 gcgcgaggcg ataccgacct cccggcacgc cgtggtttcc tccggcagga catacgggag
     6661 ggaaccgacc acgcctctct accactggac ccaggaaatc acgtgagcac agccaaccgg
     6721 gtgaacagac cacgtgttgg tctccctctc ggaggcctgc cgtccggcga ggaccttctt
     6781 tttcttgtcg caaaagaaaa aagagatgcc tcgccggcgg gcaggccgcc aagaggggac
     6841 acaacagaca ctcggtttgc cgagccggtt cgctgaaccc gcgtgacttc ctgggtcaag
     6901 tggggcgtgg ggtgcccctc ccgtatggcc tgcccaaggg aaccacaggc tgtcaagagg
     6961 tcggtagggc ctgcgctgtg ggttgggttg cgtaggccga cctcctgaca gccagtggtt
     7021 ggcttcgccc aggccatacg ggagggacac cccacgaacc acacccatgc gctatgcgcg
     7081 caagccaaac acctctccgc tttgcgcgca agccaaacac cgctgcgctc acgcacacgc
     7141 cacacccccg cgctcacccg ctcacgcgca ccccctgcgc attgcgcgca agccacaccc
     7201 cccccgctcg cgcgcatgcg acatgcgcct gcgctcacgt gcgccttgcg caccctgcgc
     7261 tcatacgcgg ctgccgccct tcagccggaa cccgcgcaca ccatccacaa cacgaccgac
     7321 ttcccgactt tgacgggacc ctgccgggtc gggcggcgcg acctacctcg acgggatatc
     7381 gttcgtcgtc ggtagagcac ctgaagaagg gtgagccgct ctgtgcgtcg tgtgtggctg
     7441 gggatcactg ttctcgcggt cttcgtgctg ccgtcctgcg gaaatccgcc ggacggcgga
     7501 caaccggtga cctcgaccga cagtcacgca ccggcacctg tggcgccgac cactgcgcag
     7561 agcgagttgc acaagcacct agtggacctg aagctgctgg tggccagcgg tccctgcgca
     7621 ccgcaggagt gcgttcaacg ggcccagtcg atcctggctc ggtccgtcgc gatcaggagg
     7681 accattctgg acagccccga ccgggggcgg ttgcggcccg cggtggacat cgtggacaga
     7741 ctggccggga tctccgccga ccaggccggt gatccgggga ttcagcggca gatcgtcgag
     7801 gtcggtgtcg agctcgtcga ctggctgggc aggaacgtca cgtggtgagg cggggagcca
     7861 ggcaaggggt cctgactccc cgctcatcca gccctactgg ttccgtgggt ggaacgtgat
     7921 gtagggcctg ctcttgtcga gtgtcgtgtt gaggaagtcg atccgccgac ccacaccgag
     7981 ttcgatcgga ccgagcggca gcgagttgcc gaccttcttc ttcgtcttgt tgttcatccc
     8041 ctcgatgatg tagtcccagt ccgattcggc atgcacgttg ccaccggccc ggctgccgac
     8101 cagggtgatc ggcctgccga tcttgtcggc cgcgttctgg attcgtctgg cctcagcggc
     8161 ggtgatgttg cccaacgacg ccccgccgcc gacttccggc ccacacgcgt tgtgcaccag
     8221 caccggcttg cccgcgacca gcacgaagta cgtgtgcagc ccggcgactg tcatgttgtg
     8281 cgccgtcgcc caccgcgctg tctcctcgcg caggcccgac acgtgaacct gatcgcctga
     8341 cgcggtcgtc aggctgtcac cggcatcgag ttcgtcggcc cgctgccact gccggtcggt
     8401 cgcgttccag aatggatggt cctcggtcgt ggcgaccttc gcgccgtcct gtgtggtcag
     8461 gtccacgacc acatcgtggt gcgaccagac agccgtgact gttctcggcg ctgatgtgcc
     8521 gctctgcgga tcggcggcga gcacttcctc accgaccttg acctcggcga tcggcttggt
     8581 cgttccgtca gccatcacca cgtgggtgtc cccggtgaag ctgcagaacc acctggtgac
     8641 gtcacccgcc gcctcgccgc cctcgtcgag tgccttgccc gccttgccga tcttccctat
     8701 cttgccgatc ttcccgagcg gcaggtcggc gaggatccac aggcacgact cctcaccgtt
     8761 gacgcagccg tcgatgctgc tgatgactcc gagcggggac agctcgaaca gcatctggcc
     8821 gaactcggga ttgtcgagct ccagcatccc gttcatgtcg gcgaacgagc agaacgacct
     8881 gtcattgggc gtgggacgtt gacagattcc cttcgcccag tcgctgagcg cctcctggta
     8941 ctcacccggc cggtagctcg cgccaccggg cagccgtccc ttcagctcgt cgaacgtcgg
     9001 cgcgcgccgg tcgaagatga tcggctggat ccgccagtcc ttgttctgcc cggtcgcgat
     9061 ctcgtagcgc ttctgctcca tccttggccc gatcggcgag agcctgttgg gtggtccggc
     9121 cgcccagacg gacgtctcgc ctttcgtgtg gtggtagtag tcgcacatgt cgcagtacgc
     9181 cccggacggg tcgctgaagg tggtcgggtt gttgttgctg taggtgtacc cgttcatctg
     9241 ttgcgcgtca gccgggttga ggatcgggtc gacggacatg aaccgcccgg tcgacggatc
     9301 gtactggcgt gcgccgagat tcgtcagccc ggtgctcttg tcctgtgtgc caccgacgaa
     9361 tccgtggtcg ttcggccagg ccgtcgcggt acctcgggcc tcgccgaacg gcaactgcct
     9421 gcgtcgggtg acgtcgagct cggccgatcc gatcgagatc tgctcggtgt tctggtggtc
     9481 gcccgcgagc caggtcaact gccccttgcc cgtgcgcatc gcgatgccct tgcccgcgtg
     9541 ggtgtagtag cgcgtgacag tggggttgcc accgctgagg ttgagccgca gttcctgacc
     9601 gtccaggtac accgtcgtgt tgtccggctc gcggcggatg agccggttgc cgtcggcgtc
     9661 gtacacgaac gacgtgctct tgccgtcctg ggtgatcttg cccagcttgc cctcgatgtc
     9721 ccaggtgaac tcctggttgc ccttgcgcgt gacggcaccg gtcaggctgt acttgtactc
     9781 ctcgctcttg tccacgcctg ggccgttggt cgtgacggag ctgagtgcgt gtgcgtgatc
     9841 gggtacgtcg tagttgtacg acttggtcgt gtcgccgcct gccgcgtgct gggtctcgac
     9901 cttccggttc ccggccttgt cgtaggtgta ggagtgccag tagggcgcgg gaccggcgag
     9961 accgttcact gcgggatcgg ccttgcagcc ctcgttgggc ttccacgtcg acacggccgg
    10021 agtccacgcc tcggtggtcc gccggaggta gtcgtgccgg aagcactgga cgtccactgt
    10081 gggcggctgg gcctgcggga cgtccgcgat ggacgtgacc gtcccggccg ggtcgtaggt
    10141 gtagttggtg tccgccacca tcggtgacgt cagttcggcg tccaccactg tccggctcag
    10201 ccgccgggtg tcggtctcgt agtagaacga ctgccagacg cgtttgtcgc ccgtgccttg
    10261 gtgcaaccgg gcgatctcgc cgtaccgggt gtactcggtc gcggtgacgt gctcgaaggt
    10321 cttgccgtcg tacccgcccc agctcctgtt c
//
