LOCUS       NZ_CDME01000004        12596 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Kibdelosporangium sp. MJ126-NF4, whole genome shotgun sequence.
ACCESSION   NZ_CDME01000004
VERSION     NZ_CDME01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium sp. MJ126-NF4
  ORGANISM  Kibdelosporangium sp. MJ126-NF4
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-NOV-2014) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000826545.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:10:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,648
            CDSs (total)                      :: 10,573
            Genes (coding)                    :: 10,470
            CDSs (with protein)               :: 10,470
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 19 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 5 of 103
            Pseudo Genes (multiple problems)  :: 10 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 119876
            Orig. end                         :: 132472
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CDME01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12596
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="1"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12596
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12596
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7596](-)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7596)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     gene            75..524
                     /locus_tag="BN1199_RS12740"
     CDS             75..524
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018685251.1"
                     /locus_tag="BN1199_RS12740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_042183074.1"
                     /transl_table=11
                     /translation="MEISSFTESDRADWEVLARSHHTHFETDVGAEGYERTWRRLLDGD
                     QIRGIAARLDGRMVGIAHYLFHSGVWSAGRCYLADLFVDPEVRRRGVATAMIEWVARDA
                     EEHGAPSLYWNTLDNAPARALYDKLAIFRGHILYTYRRDTTPVRA"
     misc_feature    complement(1046..1060)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            1264..>1962
                     /locus_tag="BN1199_RS58885"
                     /pseudo=""
     CDS             1264..>1962
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033564.0"
                     /locus_tag="BN1199_RS58885"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ISAs1 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDHAADLRELLARIEDPRDARGVRHSLAAVLTLAAVAVAAGARSI
                     AAIWEWAADLPQWALREAGARWDPRRAVFVVPSEPTLRRALSGLDGDALDIVVHAWIAS
                     RHQPGQGPREGEVAAIAIDGKALRGTFARTGGGGVHLLAGISHTVGIVTGCQQLVPVGT
                     SEVAWVESLFQGIDITDVVITADSLHTTRAAARHLTGRGGHYVFVVKKQSRRLHDLVHA
                     LPWARAEQHIT"
     misc_feature    1441..1443
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2058..2411
                     /locus_tag="BN1199_RS58890"
     CDS             2058..2411
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013752.4"
                     /locus_tag="BN1199_RS58890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_369805360.1"
                     /transl_table=11
                     /translation="MTRDRTDRATGTHESHTWVGVTSLPAHLADPARIAALLRGHWQIE
                     NRLHWVRDTAYREDASRVRTGTAPRAMATLRNLAISALRLTGATNIAQALRAMSRDITR
                     PLTLLGIPTTNRL"
     gene            complement(3102..4103)
                     /locus_tag="BN1199_RS12750"
     CDS             complement(3102..4103)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646747.1"
                     /locus_tag="BN1199_RS12750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proline racemase family protein"
                     /protein_id="WP_042183076.1"
                     /transl_table=11
                     /translation="MRAARYFTAVDSHTEGMPTRVITGGVGVVPGDTMAEKRAYFMANL
                     DHIRQFLVNEPRGHAAMSGAILQPPTRPDADTGVIYIEVSGCLPMCGHGTIGVATVLVE
                     TGMVDVVEPVTTVRLDTPAGIVVAEVRVRDGRAESVTIENVPSFALELDASVTVPGIGE
                     VRYDMAYGGNFYAILPIKDLGIPFDKSEKDRMLTAGLRIMDAINADRRPIHPTDPLIGG
                     CKHVQLVAPATATSDARNAMVIHPGWFDRSPCGTGTSARMAQLHARGELGVGQDFVNES
                     LLGTTFTGRLTEETTVGAMTAVVPTVTGRAWITGMAQYLLDPADPFPTGFTL"
     gene            complement(4105..5004)
                     /locus_tag="BN1199_RS12755"
     CDS             complement(4105..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005153898.1"
                     /locus_tag="BN1199_RS12755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_042183078.1"
                     /transl_table=11
                     /translation="MTEEKLGGVIVATALPYAEDPDAPAGLRVDLDRYADHCRWLIENG
                     CRGVGPNGSLGEYSSLTDDERRAVARTAIDAVGDKGIVVVGVHGVGSHQARHWAEVAAQ
                     DGADGVLCLPPTLYRANPSEVIKHFEQVASVGLPVMVYNNPFDTKVDLTPAVLAEIAQI
                     DNVVAVKEFSGDVRRVTEIRDVAPSLTVVAGADDVLVESVLMGATGWFAGFPNVFPAES
                     ARLFSLAMDGKLADARALYESMIGAFRWDSRTEFVQAIKYGMDYVGRYGGPCRPPRGPL
                     SAEQLTALKADMRRAVGA"
     gene            complement(5001..6257)
                     /locus_tag="BN1199_RS12760"
     CDS             complement(5001..6257)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010697119.1"
                     /locus_tag="BN1199_RS12760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD/NAD(P)-binding oxidoreductase"
                     /protein_id="WP_042183080.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-29, bitscore:
                     97.0, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 2.1e-08, bitscore: 27.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 6.4e-08, bitscore:
                     26.4, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVVIGAGPAGISAARAASTRGAHVVLVDSGPSVGGQFFRQPYD
                     RPRTLPGVEHLPSTVVWAIEGRRVHLLSGPADGPDRKARVVDADALVLATGAHDRVVPF
                     PGWDMRGVYTAGAAQILAKEQRLPIGRRVLVAGTGPFLLAVTKSLTDVGADVIAVLEAN
                     SPARWLRAPFAGRHKLGEATRYLAHLARHRIPYRPRTAVVAVHGDGHVQAATVARLDEN
                     WNILSTEQVEADAVCVAHGFTPQLELAVAAGCDLADGFVKVSFTQATSVPGVFAAGEIT
                     GIGGADLAAAEGTVAGIAAVGGRVPHDALRKVRQGRRFAAALAQAYPIGPGWRDWLATD
                     TVVCRCERVTYGALCDAVSTRAATGARTVKLVSRVGLGRCQGRTCLRNAADLTGVAFPE
                     RRPIAAPLRLGELAAEEET"
     gene            complement(6254..6457)
                     /locus_tag="BN1199_RS12765"
     CDS             complement(6254..6457)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646744.1"
                     /locus_tag="BN1199_RS12765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_042183081.1"
                     /sec_met_domain="Fer2_4 (E-value: 4.1e-15, bitscore: 49.1,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVTVDGQTVAVQPGQTIAAVLHSRGSGRIFCGIGVCFDCVVTLN
                     DVPDVRACQRTVADGDTVRTSS"
     gene            complement(6448..7596)
                     /locus_tag="BN1199_RS12770"
     CDS             complement(6448..7596)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225094.1"
                     /locus_tag="BN1199_RS12770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_042183215.1"
                     /sec_met_domain="DAO (E-value: 1e-63, bitscore: 209.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPDVVVVGAGIIGAACAEALSAAGVRVTVIDQGAPAGGTTAAGE
                     GNVLLSDKSPGPELALAQASVARWPKLLATLADLLGPGQAEVEWDAKGGLVVALENADA
                     LAEFAENQRRAGVRAEEITAADAVALEPNLNRDVLAAVHYPDDAQLQPVLAATTLLAAV
                     RRRGGQVRGGVTALGLRPGGLRTSEGFLHCGAVVNACGPWAGRFSREAGAPIDIQPRRG
                     VVLVTSHTSYTVRHKVYDADYVGAVESGAADLQTSTVVESTRAGTILIGSSRERVGFDE
                     TIRVAVLRELARKAVRLFPSLATIPIMRAYGGFRPYAPDHLPVIGPDPRVPGLWHATGH
                     EGAGIGLAAATGHLLADLFLGREPEVDPVPFRVDRPAVMTCA"
     misc_feature    complement(7381..7383)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7717..8295)
                     /locus_tag="BN1199_RS12775"
     CDS             complement(7717..8295)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945565.1"
                     /locus_tag="BN1199_RS12775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_042183082.1"
                     /transl_table=11
                     /translation="MVREQAGQVLAVNLRALRGQAGLSLSELARRSGIAKGTLSQLESG
                     TGNPTIETVFSLSNAFNVPVSSLLTEQTDPGVVLVRSPSLDVLSSNAVDLRLLRRMDLT
                     DTVVEIYDQRVRPGAIQHSDGHPGLEHVTVTAGRLRFGPPDEPYVLDPGDYICFPAHRP
                     HIYEAVDGPVMSVLLLQYPAGAVASPVHS"
     gene            8384..9937
                     /locus_tag="BN1199_RS12780"
     CDS             8384..9937
                     /EC_number="6.1.1.10"
                     /GO_function="GO:0004825 - methionine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023746.1"
                     /locus_tag="BN1199_RS12780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methionine--tRNA ligase"
                     /protein_id="WP_042183083.1"
                     /transl_table=11
                     /translation="MAEAAFISTTIPYVNAQPHLGHAFEYSQADAYARHMASRGMDVYF
                     LSGSDENSLKNVLAAEKEGITARELVDRNVVFFEQMATDLQTKLSRFIRTSVDQDHIDG
                     AVEIWRRMEARGDIYAKDYEGLYCVGCEQFYSPAELVDGKCPEHFTVPDLVSERNYFFR
                     LSNYQEKLLSALESGELKVVPESRLNEVASFVRSGLEDISISRSTGRARGWGIPVPGDE
                     KQVMYVWIDALTNYTNALGWTRDGDEYQKYWVDAAKRVHVVGKGVTRFHAVYWPAMLMS
                     AGLPMPTEVVVHGYITASGQKLSKTTGNVVDPADLVERFGPHAVRYFLLAEFSPFIDGD
                     FSEEKLIARYNADLANGLGNLLSRATSMTVRYRDGVIPEPVEIGDPERSLAEQLATSEQ
                     ASVTAMAGYDHREALARIWDLVRRTNAYVDERAPWHLAKDPAQAAALDTTLHYLAGAVR
                     QLGRLLLPFLPVAGETIVRTLGSEPDKVPGAQNWLDGLAGVQVTKSAALFPRIEAPAAE
                     "
     misc_feature    8419..8430
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     misc_feature    complement(9962..9977)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            10026..10565
                     /locus_tag="BN1199_RS12785"
     CDS             10026..10565
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017985528.1"
                     /locus_tag="BN1199_RS12785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_042183087.1"
                     /transl_table=11
                     /translation="MDITVESRALVVVAGLPGSGKSTLLRRTQANAPIRVLDTDHMRSL
                     LADMLPRTVPYGWYRPLVHVLHAARVLAVVLFSRHPVLVHDPATGAGSRTVFAVIGFLS
                     GRERHFIWIDCTPDEALAGQVARGRVLLKWSFARHMRRSPLVRSRLLAGRRPPGWSSAQ
                     MVDRDVASSGLYLKVA"
     misc_feature    complement(10580..10596)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.23"
                     /tool="antismash"
     misc_feature    10695..10711
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.4"
                     /tool="antismash"
     misc_feature    10717..10733
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.4"
                     /tool="antismash"
     misc_feature    11362..11378
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    12499..12513
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 tgagtacgac aaccgcccac cttccgccgg aactgcgcag cggcggaatc tgatcattgc
       61 ggcaggatgg tcggatggag atcagctctt tcacagaatc cgaccgcgcc gactgggaag
      121 tgctggcccg cagccaccac acccacttcg agaccgacgt cggtgccgaa ggctacgaac
      181 gaacctggcg gcggctgctc gacggtgacc agatccgcgg gatcgccgcg cggctggacg
      241 gcaggatggt cggcatcgcg cactacctgt tccacagcgg cgtctggtca gcggggcgat
      301 gctatctggc ggacctgttc gtggacccgg aagtccggcg gcggggtgtc gcgacggcga
      361 tgatcgagtg ggtggcgcgg gacgccgagg agcacggcgc cccaagcctg tactggaaca
      421 cgttggacaa cgctcccgct cgcgcgctgt acgacaaact ggccatcttc cggggccaca
      481 tcctctacac ctaccggcgc gacacgaccc ctgtcagagc atgaatcctg tgccgcaacg
      541 gcaagagtcg aaggaggacg cgggacgacg aacacggcgc cttgcctcgc accccagggc
      601 atgccgcacc caacccgggc aggtcccgtc aaagccggga agttggtcgt gtgttgtgga
      661 tggtatgcgg gtttcggctg gaggacggcc gccgcgcgta agagcgcagg ggtgcgtggc
      721 gtgcgcgcgc gaacgctcag gggtgtggtt cgtggggtgt ccctcccgta tggcctgggc
      781 gaagccatac cacgacgtgt cgggaggtcg gcctacgaaa ctggcgtgcc cggcgcgagg
      841 cggtaccgat ctcccggcac gtcgtggttt cctttggcag gtcatacggg aggggcgccc
      901 cgcgcccccc actcgaccca ggaagccacg tgggttaagc gaaccggctg ggcgaacaga
      961 gtttgtgtgt gtccctcttg gcggcctgcc cgccggcgag gcatctcttt ttcttccccc
     1021 gctgacacgc gaccgactgg ccgactggcc gactgtgacc gaaaccttgg ttccacgccc
     1081 cataagacag tcccccgccc aacccgggca gggctccgtc aaagtcggtg acccgtatga
     1141 gtgcgggcac ggcctctagt tgatcatgag agtgtctacg tcacacgatc atgtgagaga
     1201 gccgtgcctg ccgcgttatc ttcgccgatc accgctgtgc tggatcaact gggcccggtg
     1261 accgtggacc atgccgctga cctgcgggag ttgctggccc ggatcgagga tccgcgggac
     1321 gctcggggtg ttcggcattc gctggcggcg gtgctgacct tggcggcggt cgcggtcgcc
     1381 gccggtgccc ggtcgatcgc ggcgatctgg gaatgggcgg ctgacctgcc gcagtgggcg
     1441 ttacgagagg ctggcgcgcg atgggatccg cgacgcgccg tgtttgtcgt gccgagtgag
     1501 cccactctgc gccgggcgtt gtccgggctg gacggtgacg cgctcgacat cgtggtccat
     1561 gcctggatcg ccagccggca ccagcctggc cagggcccgc gggagggtga agtggccgcg
     1621 atcgcgatcg atggcaaggc cctgcgaggg accttcgcgc ggaccggggg tggcggggtg
     1681 catctgctgg ccgggatcag ccacaccgtc ggcatcgtga ccggctgtca gcagttggta
     1741 ccggtcggga ccagcgaggt cgcctgggtg gaatccctgt tccagggtat cgacatcacc
     1801 gatgtcgtga tcaccgccga cagtctgcac accacccgcg ccgccgcccg ccatctgacc
     1861 ggccgtggcg ggcactacgt gttcgtcgtg aaaaaacagt cccggcgcct gcatgacctg
     1921 gtgcacgcac tgccctgggc ccgtgctgag cagcacatca cgctggagaa agcgcatggc
     1981 cggatcgaac accgcgccct gcgactcctc cccgccccgg acagcatggt ttccctggca
     2041 ccgcacaggt tttccggatc acccgcgacc gcaccgaccg cgccaccggc acacacgaaa
     2101 gccacacctg ggtcggtgtc accagcctcc ccgcccacct ggccgacccg gcccggatcg
     2161 cggccctgct gcgcgggcac tggcagatcg aaaacagact gcactgggtc cgcgacaccg
     2221 cctaccgcga agacgcgtcc cgggtccgca ccggcaccgc accccgcgcc atggccaccc
     2281 tgcgcaacct cgccatcagc gccctacgcc tcaccggcgc caccaacatc gcccaagcac
     2341 tacgcgccat gagccgagac atcacccgac ccctcacact cctcggaatc cccaccacca
     2401 accgactttg acggagccct gacccaaccc ggggggcgtc cctgctccag cctacaggca
     2461 ataacgcctg gtcaacgggt tactggcggg ttgtggacaa cgagattcgc cgatgatccc
     2521 ttcgcctcag ggacgagact gtgatgcccg ccgtgtcggg ccttgttccc gacactcgag
     2581 ttcactggtg gcacaaagag aatgtcctcg ccggacggca ggccaccaag agggaaacca
     2641 acacatggtc tgcccacccg gttggctcag cccacgtgac ttcccgggtc cagtggtaga
     2701 gaggcgtggt cggtcccctc ccgtatgacc tgccagagga aaccacgacg tgccgggaga
     2761 tcggtaccgc ctgcgctgtg ggtcggtttg cgtaggccga cctcccgaca cgccatggta
     2821 tggctacgcc caggccatac gggaggaaac caaccacgaa gcacccgctt gcgctatgcg
     2881 cgcaagactt gcgcttgttt tgcgcgcaac cccgactttg atggaacgct gcccaacccg
     2941 gggggcgtcc ctgctccagt cctccggcgg agcaagatcg acagtggtta ggtcgtgcac
     3001 gctgtggaca atccgatgac tgtggacaac tgggcaggat gatcttcggc ggccgctgca
     3061 ccgccgaagg tcgcgttagg ctgaccgtgt gcgaactcct gtcagagcgt gaatcccgtg
     3121 gggaacggat cggcggggtc cagcaggtac tgtgccatcc ctgtgatcca cgcgcggccg
     3181 gtcacggtgg gcacgacggc tgtcattgcg ccgaccgtgg tctcctcggt gagccgcccg
     3241 gtgaaggtgg tgccgagcag ggactcgttc acgaagtcct gccccacacc tagttcaccg
     3301 cgtgcgtgca gttgtgccat ccgcgcggaa gttcctgtgc cgcaggggga tcggtcgaac
     3361 cagccggggt ggatgaccat ggcgttgcgt gcgtcgctcg tggctgtcgc gggtgccacc
     3421 agttggacgt gtttgcatcc tccgatcagg gggtcggtgg ggtggatcgg gcggcggtcg
     3481 gcgttgatcg cgtccatgat ccgcagtccc gccgtcagca ttctgtcctt ttcggacttg
     3541 tcgaacggga ttccgaggtc cttgatcggc aggatggcgt agaagttccc gccgtaggcc
     3601 atgtcgtagc ggacctcgcc gatccccggc acggtcacgg acgcgtcgag ctccagcgcg
     3661 aacgagggca cgttctcgat ggtgaccgac tcggcacggc cgtcacggac acgcacctcg
     3721 gcgacgacga tgcccgcagg tgtgtccagc cgaacggtgg tcacgggttc gacgacgtcg
     3781 accatgccgg tctccacgag cacggtcgcc acgccgatgg ttccgtggcc gcacatcggc
     3841 aggcagccgg agacctcgat gtagatcacg ccggtgtcgg cgtccggcct ggtcggtggc
     3901 tgcaggatcg cgccgctcat ggccgcgtgc ccgcggggtt cgttgaccag gaactggcgg
     3961 atgtgatcca ggttcgccat gaagtacgcg cgtttctcgg ccatcgtgtc gccggggacc
     4021 acgccgacgc cgccggtgat cacacgggtc ggcatgccct cggtgtgcga gtcgaccgcg
     4081 gtgaagtagc gagccgcgcg catgtcaggc tcccaccgcg cgccgcatgt cggccttcag
     4141 tgccgtgagt tgctcagcgg acaacggtcc acggggtggc ctgcacggtc cgccatagcg
     4201 gccgacgtag tccatgccgt acttgatcgc ctggacgaac tcggtccggg agtcccagcg
     4261 gaacgccccg atcatggatt cgtacagcgc gcgggcgtcg gccagttttc cgtccatggc
     4321 gagggagaac agtcgcgcgg actcggcggg gaagacgttc gggaacccgg cgaaccagcc
     4381 cgtcgccccc atcaacaccg actcgaccag cacgtcgtcg gctccggcga ccacggtcag
     4441 gctcggcgcg acatcgcgga tctcggtcac gcgacgcaca tcgccggaga actccttgac
     4501 cgcgaccacg ttgtcgatct gggcgatctc cgcgagcacg gccggggtca ggtcgacctt
     4561 ggtgtcgaac gggttgttgt agaccatcac cggcaggccc accgacgcga cctgctcgaa
     4621 gtgcttgatc acttcggacg ggttggcccg gtacagcgtg ggtggcaggc agagcacgcc
     4681 gtccgcgccg tcctgcgccg ccacctcggc ccagtgccgt gcctggtgcg agccgacgcc
     4741 gtgcacgccg accacgacga ttcccttgtc gccgacggcg tcgatcgcgg tccgcgccac
     4801 cgccctgcgc tcgtcgtcgg tcagtgagga gtactcgccg agcgacccgt tcgggccgac
     4861 gccccggcat ccgttctcga tcagccagcg gcagtggtct gcgtagcggt ccaggtcgac
     4921 gcggagtccg gccggtgcgt ccgggtcctc ggcgtagggc aacgcggtcg cgacgatgac
     4981 gccgccgagc ttttcctcgg tcatgtttcc tcctcggctg cgagttcgcc caggcgcagc
     5041 ggtgccgcta tcgggcgtcg ttcggggaat gccactccgg tcaggtctgc ggcgttgcgc
     5101 aggcaggtcc ggccttggca gcggccaagg cccactcggc tgaccagctt cacggtccgt
     5161 gcgccggtgg cggctcgggt gctgacggca tcgcacagcg cgccgtacgt gactcgctcg
     5221 cagcggcaga cgacggtgtc ggtggccagc cagtcgcgcc accccggtcc gatcgggtac
     5281 gcctgggcca aggcggccgc gaacctgcgg ccttgtcgta ctttccgcag tgcgtcgtgg
     5341 ggcacccggc cgccgactgc ggcgatcccg gcgacggttc cctcggcggc ggcgaggtcc
     5401 gcgccgccga tcccggtgat ctccccggcc gcgaacacgc cggggactga cgtcgcctgt
     5461 gtgaagctga ccttcacaaa cccgtcggcc aggtcacagc ccgccgcgac cgcgagttcg
     5521 agttgcgggg tgaagccgtg ggcgacgcac accgcgtcgg cctcgacctg ctcggtgctc
     5581 aggatgttcc agttctcgtc gagccgggcg acggtcgcgg cctggacgtg gccgtctccg
     5641 tggaccgcca cgaccgctgt tcgcgggcgg tacgggatgc ggtggcgcgc caggtgagcc
     5701 aggtaccgcg tggcctcgcc gagcttgtgt ctccctgcga acggggcgcg cagccagcgc
     5761 gccggggagt tggcctctag gacggcgatc acgtcggcgc cgacgtcggt caacgacttc
     5821 gtgacggcca gcaggaacgg cccggtcccg gcgacgagta cgcggcggcc gatcgggagg
     5881 cgctgttcct tggccaggat ctgggcagct ccggcggtgt acacaccgcg catgtcccag
     5941 cccgggaacg gcacgacgcg gtcatgggcg ccggtcgcga gcacaagcgc gtcggcgtcg
     6001 accaccctgg cttttctatc cggcccgtcg gctggaccgg acagcaggtg cacgcggcgg
     6061 ccttcgatcg cccagaccac ggtgctcggc aggtgttcga cgccgggaag cgtgcgtgga
     6121 cggtcgtagg gctggcggaa gaactggccg cccacggacg gcccggaatc gacgaggacc
     6181 acgtgcgcac cgcgcgtgga cgctgcccgt gcggcgctga ttccggcggg tccggcgccg
     6241 atgacgacca ccttcatgac gaggtccgaa cagtgtcgcc atccgccact gtccgctggc
     6301 acgcgcggac gtccggcaca tcgttcagcg tgactacaca gtcgaagcag acaccgatcc
     6361 cgcagaagat ccggccgctt cccctgctgt gaagtaccgc tgcaatggtc tggccgggct
     6421 ggacggccac ggtctggccg tcgacagtca cgcgcatgtc atcaccgccg gacggtctac
     6481 tcggaagggg acggggtcga cctcgggttc tcgtccgagg aacaggtcag ccagcaggtg
     6541 gcccgtcgcg gcggccagtc cgattcctgc gccttcgtgg ccggtggcgt gccagagtcc
     6601 gggtactcgc gggtccgggc cgatcacggg caggtggtcg ggcgcgtatg gccggaatcc
     6661 accgtacgcg cgcatgatcg ggatggtggc caggctggga aagagccgga ccgccttgcg
     6721 ggccagttcg cgcagcacgg ccacccggat ggtctcgtcg aagccgacgc gttcccggct
     6781 cgacccgatc aggatcgtgc ccgcgcgcgt ggattcgacc accgtggacg tttgcaggtc
     6841 agcggccccg ctctccaccg cgcccacgta gtccgcgtcg tacaccttgt gccgcacggt
     6901 gtacgaggta tggctcgtca cgaggaccac tcccctgcgc ggctggatgt cgatcggcgc
     6961 gcccgcttcc cggctgaacc gaccggccca cgggccgcag gcgttgacca ccgcgccgca
     7021 gtgaaggaaa ccttcagagg tccgcagccc gcctggtcgc agccccagcg cggtgacgcc
     7081 accgcggacc tgaccgccgc gccgtcgcac cgcggccagc aaggtcgtcg ccgccagaac
     7141 gggctggagt tgtgcgtcgt cggggtagtg cacggcggcg agcacgtccc ggttcaggtt
     7201 cggttcgagc gccaccgcgt cggccgctgt gatctcctcc gcgcggacac cggcgcggcg
     7261 ttggttctcg gcgaactcgg ccagcgcgtc ggcgttctcc agcgcgacca ccaggccgcc
     7321 tttcgcgtcc cattccacct cggcctgccc gggtcccagc aggtcagcga gggtggccag
     7381 taatttcggc caccgggcga ccgaggcctg ggccagcgcg agctcggggc cgggcgactt
     7441 gtcggacagc aggacattgc cctcgcccgc cgcggtcgtg ccgcccgctg gcgcgccctg
     7501 gtcgatgacg gtgacccgga ctccggccgc gctgagcgcc tcggcgcacg ccgcgccgat
     7561 gatgcccgct ccgacgacca cgacgtccgg ctgcatgacc accaccgttc attaaagtga
     7621 acgacagcag ggtaactccg atctgcggcg agtccaatgg gccgttcgga gtgcgctggg
     7681 ctgatgggag tgggctgatg ggagtgggct gggcagtcag gagtgcactg gcgaggccac
     7741 cgcgcctgcc gggtactgca ggagcaggac cgacatcacc ggaccgtcga cggcctcgta
     7801 gatgtgcggg cggtgcgccg ggaagcagat gtagtcgccg gggtcgagga cgtagggctc
     7861 gtccggcggg ccgaaccgca gccgaccagc cgtgaccgtg acgtgctcca ggcccggatg
     7921 cccgtcggaa tgctggatcg cgcctggtcg gacgcgctgg tcgtagattt cgaccaccgt
     7981 gtcggtcagg tccatccggc gcagcaaccg cagatcgacc gcgttgctgc tgagcacgtc
     8041 caggctcggc gaacgcacca ggaccacgcc gggatcggtc tgctcggtca gcaggctgga
     8101 caccgggacg ttgaaagcgt tcgacaaact gaacacggtc tcgatcgtcg ggttgccggt
     8161 ccccgactcc agctgcgaga gggtgccctt ggcgatgccg gagcgcctgg ccagttccga
     8221 cagcgacaga ccggcctgcc cgcgcagcgc cctgaggttc acggccagca cctgaccagc
     8281 ttgttccctg accacaccgg cctcctcgcg ctcgcccggc gaaggctacc caaccactgg
     8341 tggataagct ttggtatccg gcattcaaga ggttaggaag atcatggccg aggccgcttt
     8401 catctcgacg accatcccgt acgtgaacgc acagccgcac ctgggccacg cgttcgagta
     8461 cagccaggcc gacgcgtacg cgcggcacat ggcaagccgg ggtatggacg tctacttcct
     8521 gagcggctcg gacgagaaca gcctcaagaa cgtgctggcc gcggagaagg aagggatcac
     8581 cgcgcgcgag ctggtcgacc gcaacgtcgt cttcttcgag cagatggcca ccgacctgca
     8641 gaccaagctg tcccggttca tccgcaccag cgtcgaccag gaccacatcg acggcgcggt
     8701 cgagatctgg cgccggatgg aggcccgcgg cgacatctac gccaaggact acgagggcct
     8761 gtactgcgtg ggctgcgagc agttctacag ccccgccgag ctggtcgacg gcaagtgccc
     8821 cgagcacttc accgtgcccg acctggtcag cgagcggaac tacttcttcc gactgtcgaa
     8881 ctatcaagaa aaactgttga gcgcgctcga gtccggtgag ctgaaggtgg tcccggagtc
     8941 gcgcctcaac gaggtcgcca gcttcgtccg gtccggcctc gaggacatct cgatctcccg
     9001 gtcgaccggt cgcgcccgtg gctggggcat cccggtcccc ggtgacgaga agcaggtcat
     9061 gtacgtctgg atcgacgcgc tgaccaacta caccaacgcg ctgggctgga cccgcgacgg
     9121 cgacgaatac cagaagtact gggtggacgc ggccaagcgt gtgcacgtgg tcggcaaggg
     9181 cgtcacccgg ttccacgcgg tgtactggcc cgcgatgctg atgtcggccg gtctgccgat
     9241 gccgaccgag gtggtcgtgc acggctacat caccgcgtcc ggccagaagc tgagcaagac
     9301 caccggcaac gtcgtcgacc cggccgatct ggtcgagcgg ttcggcccgc acgccgtgcg
     9361 ctacttcctg ctcgccgagt tctcgccgtt catcgacggt gacttcagcg aggaaaagct
     9421 gatcgcgcgc tacaacgccg atctggccaa cggcctgggc aacctgctgt cgcgggcgac
     9481 gagcatgacc gtgcgctacc gcgatggcgt cattcccgag ccggtcgaga tcggggaccc
     9541 ggagcgctcg ctggccgagc agttggccac gagcgaacag gcgtccgtga cggcgatggc
     9601 cgggtacgac caccgtgagg cccttgcccg gatctgggac ctggtccgcc gcaccaacgc
     9661 gtacgtcgac gagcgcgccc cgtggcacct ggcgaaggac ccggcgcagg ccgcggcgct
     9721 ggacaccacg ctgcactacc tggccggcgc ggtgcgccag ctcggccggt tgctgctgcc
     9781 gttcctgccc gtggccggtg agacgatcgt gcgcacgctg ggctccgagc cggacaaggt
     9841 ccccggcgcg cagaactggc tcgacgggct ggccggtgtg caggtgacca agtccgcagc
     9901 gctgttcccc cggatcgagg caccggccgc cgagtgaggt acggggccga gtgtgaggtc
     9961 gggggaaaaa ccctgaatcc ggcgtatcgg gagaactgac aagcacaacc gtacgttgtg
    10021 cggatatgga cattacggtc gaaagccggg cgctggtcgt cgtggcgggc ttgcccgggt
    10081 cgggcaagag cacgctgctg cgacgaaccc aggccaacgc gcctattcgc gtgctcgaca
    10141 ccgaccacat gcggtccttg ctggcggaca tgctgcctcg cacggtcccg tacggctggt
    10201 accgaccgct ggtgcacgtg ctgcatgccg cgcgtgtgct ggcggtcgtg ctgttctctc
    10261 ggcacccggt gctggtgcac gacccggcca ctggtgcggg gtcgcggacg gtgttcgcgg
    10321 tgatcggttt cctgtcgggg cgggaacggc atttcatctg gatcgactgc acgcccgacg
    10381 aggcgctcgc cggtcaggtg gcgcgtgggc gtgtgctgtt gaaatggtcg ttcgccaggc
    10441 atatgcgccg gtctcccctg gtccgttcgc gactgcttgc cgggcgacgg ccgccgggct
    10501 ggagcagcgc gcaaatggtt gaccgggatg tcgcgagttc cggcctgtat ctcaaggtcg
    10561 cctgacgccc caaccgccgt gtccaccttt ccggcacgcc gtgtccacca ttccggcacc
    10621 atgaaattcc ctgagaaggg cctgtgacag ggcgagatca cgcatttcat ggtgccggaa
    10681 agtgcatttc gtggtgctgg aaaggtggac acgatgtgct ggaaaggtgg acacggtggg
    10741 gcggggggtg tcagctgcgt aggtggagga tttttagtgc gggtgatgtc aggatctcgt
    10801 gctcacagaa tcggccgcgc acccatttgc cctcggagaa cagtttcgtc tggtcggcgt
    10861 ggtatggcga ggttgggtcg gtcgactgcg agtaggtgag cagtgtccgc acgtccgggc
    10921 agtggccgcc gtcgaacgcc accgcttgga tgtagctgga tccgtgtacc agttcggtgt
    10981 ttcccttcgc cgggtcccag gcggggatct gcatgttgag cacgccgagg ctgttgggcc
    11041 cgccgtgcac cgggatccgt tcgccgttgc ggacgacgta ctggtattcg ccgagtggcg
    11101 cgtccatcgg gatcttcgcc gcgcgcatct cggcgacggc gtcggtgaag gctttgcgga
    11161 tcgccgggct gtcggtgttg agggtgttgg gggtgtggat cgggtcggcc gcgtcgaacg
    11221 gcaccttcca cgggtcctcg gggatgtccg gcatcttcgc ccagaaccgc tcgaacagca
    11281 gcgcgcctct actccctgtg gagtacgtct tgtcccaatg tctaacggcc gcgcaggcgt
    11341 ccgcgacgtt cggcagcgtg tcgcacattt ttgccgtgtc gtccgcagcg acctggccga
    11401 tcaggctgcg gtcggtgaac agcgtgtcct ggatggcctg ccgggagaac cgcttgccgt
    11461 tcagctcggt gatggccatc cgggtgcgtg ggccgcgctc ggtggccacg tcgccgatga
    11521 tccgcgggta gttcgtgatc ggcgcggccg ggttggtcag ccaggcgctg tcgttggagt
    11581 tggccacgta gtcggccctg gtcagcactg gctgcttggc tgggccaagc agtccgggcg
    11641 cgaccgcgtc gcggtcgttg ccccaggcac agctggtctt cgcgccgtcg agcacggcga
    11701 cgccggtcga cgggaacacc gccgcgccca gtggcgtgtt gcactgccgg gccaggtcgt
    11761 cggtgatgtg cgggaccacc tggatgtcgg cgtaggtcgc gttgcccgac ctgtccgtgg
    11821 cgatcgtgtt gacccacggc gagccctggg tgtccgacag cgccttgacg atgccgcgcg
    11881 tgtcgcgggc ctgcgcgatc tcgaaccagg tgttgaccga gcggatgttg ccccagttgg
    11941 cgtcgcggag gacgtaggcc gtgctgctcg tccagcccaa cggcaggtcg aacgcttcac
    12001 cgatgaccgg cccgtaccgg gtggaccaca gcgttcgctc gacctggccc aggctgccgt
    12061 cggcgttgcg gctgcgcacg gtgaccttgc ggctggtcat ctgctcgggt ttgccgtcga
    12121 ccaggtatgt cgtcggtgag ccggggacca gttgcagttg gtagaagccg aatgttcgcg
    12181 gggtggccac cgtgtgcgtc cacgcgatgt ccttggtgta gccgatctgc acaaagggca
    12241 ggccgagcag gctcgctccg gaaacgtcca gcttgccggg gatggtcagc tgggactgcc
    12301 agaaccggcg gccgccgtgc caggggaagt gcgggttgcc caggagcagg ctcttggcgc
    12361 ccgccgtggc gtcacggccg aaggcgaagc cgttgctgcc catgtccttg gtgacttcga
    12421 gcgcgtcggc gcgcttgcgg gcggcgtccg gcgggaccgc ggcggcctgt gcctggcccg
    12481 ccggtggctg ggcggtggcg atctggtcgg ccagcagcgc ctggccgctc atcgtggaca
    12541 gggcatgcag gtgccggtag acgtcgatct ccgagatcgg ccggacccat gcggcg
//
