LOCUS       NZ_CDME01000002        10795 bp    DNA     linear   CON 13-AUG-2024
DEFINITION  Kibdelosporangium sp. MJ126-NF4, whole genome shotgun sequence.
ACCESSION   NZ_CDME01000002
VERSION     NZ_CDME01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium sp. MJ126-NF4
  ORGANISM  Kibdelosporangium sp. MJ126-NF4
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Ramaraj,Thiru.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-NOV-2014) National Center for Genome Resources (NCGR),
            National Center for Genome Resources (NCGR), 2935 Rodeo Park Drive
            East, Santa Fe, New Mexico, 87505, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000826545.1-RS_2024_08_13
            Annotation Date                   :: 08/13/2024 03:10:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,648
            CDSs (total)                      :: 10,573
            Genes (coding)                    :: 10,470
            CDSs (with protein)               :: 10,470
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 19 of 103
            Pseudo Genes (incomplete)         :: 89 of 103
            Pseudo Genes (internal stop)      :: 5 of 103
            Pseudo Genes (multiple problems)  :: 10 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:05:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2086102
            Orig. end                         :: 2096897
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CDME01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10795
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="15"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10795
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10795
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5795](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5795
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            904..2166
                     /gene="hisS"
                     /locus_tag="BN1199_RS09385"
     CDS             904..2166
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="BN1199_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_042180867.1"
                     /transl_table=11
                     /translation="MDNSPARGTRDLLPATVAVRDHVLARITEVYHRYGYQRIETPALE
                     DITRLTGGQGGENEKLIFKILRRGLTEFPASMDELADLGLRFDLTVPLTRFYGNNHASL
                     PTPFRSFQIGPVWRAERPQKDRYRQFYQCDIDVIGEESVLAEAELIEATTEALEAVGLP
                     GTTVRLSDRRFLSALAEGAGVAPEAQGSFFITLDKLDKIGWDGVRKELTERAGFTEAQA
                     DGVQTAITALQGLDPAKLADQLADAVPNLPEGVAADLAATTTALAELATTRELGWEFDP
                     TLVRGMGYYTGQIFEVSHPGTSASVAGGGRYDKLIGRSLGKDVPACGFSIGFERIVNLL
                     DNAPRVDAVAVLHEADVTPAEVLAVARRLRAEGRQVTAIKRRGKFGAQLGRLAEWGFTS
                     MVHVKPGEVADERVLGSRESS"
     misc_feature    953..968
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.45"
                     /tool="antismash"
     gene            2185..2490
                     /locus_tag="BN1199_RS09390"
     CDS             2185..2490
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004560769.1"
                     /locus_tag="BN1199_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_042180869.1"
                     /transl_table=11
                     /translation="MAVNASPDEPASQRFREDLEGLDPHDPEVREFAAHLDRIEKSRSG
                     YTVEGYLGGISDFADSANRLGGHYRMLALLVICLILVGVVVAAWDTLVLILTSLGG"
     gene            2491..2937
                     /gene="msrB"
                     /locus_tag="BN1199_RS09395"
     CDS             2491..2937
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099307.1"
                     /locus_tag="BN1199_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_042180871.1"
                     /transl_table=11
                     /translation="MSKKPVTGVTPRVVKSDQEWRQQLTAEEYAVLRKAGTERPFTGEY
                     TDTKTVGVYACRACGAELFRSATKFDSHCGWPSFFSPLAGDTVILREDRDLGMVRTEVL
                     CATCHSHLGHVFEGEGYPTPTDQRYCINSISLTLRPGTDADEEA"
     misc_feature    3118..3133
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.56"
                     /tool="antismash"
     misc_feature    complement(3127..3142)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            3147..3926
                     /locus_tag="BN1199_RS09400"
     CDS             3147..3926
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BN1199_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_369805345.1"
                     /transl_table=11
                     /translation="MLTRSGAATTAPVESLTALELAGLTGGPPRVVEAAIAQLVENGGL
                     RAARDGYLQVVGLGGGSNPVERSVLADVTRHGRRSITMLTYRLARSDAVGEVMAGLVRS
                     GYLVDGEVAQRRKAVSMIPVAAVFAVGVLRWLSGIAADRPIGWLTVLLIGSGLIGYFLY
                     RQAICPRTFAGVNAVERVSASEPVDLVAAGGFASHPDRTVRESLLGGQYHRLSRTGMLG
                     GAAWWLGSGGAGSTGGGGAGCGASGGSSGCGGGGCGG"
     gene            4002..4889
                     /locus_tag="BN1199_RS09405"
     CDS             4002..4889
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BN1199_RS09405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_083466242.1"
                     /transl_table=11
                     /translation="MGNPWGISGPAFLWLYSGGLVLAGIITLALRRRAWSTGTANLTEP
                     LTVDEMAFAAGGRTRMVESAIANLVDHGAVRIERSGQLHAVAESPYRPESELEERLVGD
                     ITQRPGRMMDYYQRRAMRLPLYDQVRDGLERRGLYVRDVGRGALFLAASPLAVLLVIGV
                     VRAVNGASLGYPIGYLTMLIILTGVALGFALRPVRRGPVPQARKVLRGGGHTGTSAAAL
                     VARGGMVAYPDPLISQLFRAPQRRTAAQSYRRAGQPAGSAGFSLGGGCSSGGGSSCSGG
                     GSSGGGGCGGGGGS"
     gene            5001..5795
                     /locus_tag="BN1199_RS09410"
     CDS             5001..5795
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983665.1"
                     /locus_tag="BN1199_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_232327887.1"
                     /sec_met_domain="DUF692 (E-value: 6.1e-83, bitscore: 275.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDLGVGIGWRPEIDITVERLSGVDFVEVVAENLDPGHLPESIVV
                     LRERGMPVLPHAVSLSVGGAEPVDLKRVEHLAKLADVLGAPVASDHVCFVRAGGLDSGH
                     LMPVPRTKEALDVLVDNVKIVQDNLNVPFALENIAALLEWPDAELTEAQFLGELTERTG
                     CLLLIDVANMYANARNLNQDPEKLLDGLPLERLAYVHVAGGEEHHGVYHDTHTHPVLPE
                     VLDLLSELVKRTRPPGVLLERDGDYPTDAELAAELRAIRERL"
     gene            5803..6150
                     /locus_tag="BN1199_RS09415"
     CDS             5803..6150
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099301.1"
                     /locus_tag="BN1199_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_042180878.1"
                     /transl_table=11
                     /translation="MTQPQRDQLAEQQARLLRALLADGPPPPGFDPQRLRVEATALRSK
                     RRRVVAMIQPDVCADLEDRFVPLFTEYAKAHPRTVGSRAREDAAAFVEWLREHGHLPKL
                     KWWRRRATKNG"
     gene            6131..6679
                     /locus_tag="BN1199_RS09420"
     CDS             6131..6679
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN1199_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157527409.1"
                     /transl_table=11
                     /translation="MQRKTGERRPTGVTRNLAAAIALAAAALVFAAVALTARDPRVPCP
                     LIGSRSGISLEVDPAYGPRIGTARLTTCWNSACTTTSLKLSPSSTSVPMPCTPGGPDNA
                     CARMEPTSGKYSFAELANLPTSPVEVTVDLIDPTGVTLSSPRLVITPTLQSSGGPECGS
                     PTPQGGLLVAANGALSEDL"
     gene            6850..10089
                     /locus_tag="BN1199_RS09430"
     CDS             6850..10089
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099299.1"
                     /locus_tag="BN1199_RS09430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_198151309.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.9e-61, bitscore:
                     204.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSVNNRAARRVGVGALVLGVALSTAQVSAAAEARVSQQDGRSVT
                     LITGDRVVVVDAAYNARSIVPGKGREKVAFSTYKRDGHLFVIPQDAVSLVAQGRLDERL
                     FDVTTLAESGYDDAHRSTLPLIVSHAPGARIAGARTTANLPALNASALAADKTGAAWQS
                     LTAGNVKKVWLDGKRTASLDRSTAQIGAPAAWQAGYTGEGVKVAVLDTGVDQTHPDLTS
                     RETAEQNFTDAADTVDRVGHGTHVASTIAGTGAKAGGKYKGVAYGANIIDGKVLNDNGS
                     GYDSWIIAGMQWAVDQGAKVVNLSLGGPDSPDNDPLEEAVNTLSAKNGTLFVIAAGNSG
                     PGAESISSPGSADAALTVGAVDREDGLAPFSSRGPRIGDAGIKPDITGPGVGIAAAKAA
                     NGRLGTPVVDGYVSMSGTSMATPHVAGSAALLAQVHPDWTGEQLKATLTASAKPNAKLN
                     AFQQGSGRVDAAKAITQAVTASPSSLSLGTQPWPHDDDQPVSKGVTYRNTGKTDVTFDV
                     KVNAIGPDGKTPPAGLLTASPAKVTVPAGGEAKVTVTADTRIDTLDGVYSGTLTATSGD
                     SGVSTPVSVNREPESYSLTINHIGLDGAPASNYRTSMFGLDSMKMSSAYDADGSATIRL
                     AKGRYTIDSSLLGDQINWLSFPSFTLTEDTTIDLDFRRTKQTKVAPPDPAAELTLADLT
                     YQRTAGKGSFGYGWVLLGGDLGRMYTGHVGPEVPPQELLFQVNTQWDTPTGEYYGLAYY
                     QYGTIPTGFTRAPKKDQLAHVHASFGSPAADRSGLRYAFPYPKFGEGPGAWATLLPVKL
                     PGDRTEYYSTEDTAWSPGLWQMSPDESDIEVDLTSPVKVLQAGRTYEESYNRGVFAPAL
                     PQTRSPWQYLVRSENKITVNVPLFGDAAGNSGSSLVDSSSTVLYRDGKKIGESKDPGYG
                     QFTVPADTGTYTLTTEAVRSGVSDVSTAVRAAWTFRSGPVGTDPVRLPLSTVRYTPALD
                     ATNSAPAGESFIVPVSVQAQNSNQGTVPKSLSVEASFDGGQTWTATTVVANVFAIVQHP
                     NDATSVSLRAKATDRAGNTVEQTIINAYKLN"
     gene            10217..10753
                     /locus_tag="BN1199_RS09435"
     CDS             10217..10753
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229886.1"
                     /locus_tag="BN1199_RS09435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6328 family protein"
                     /protein_id="WP_042180882.1"
                     /transl_table=11
                     /translation="MHPQHTAQHRAQSRTPDADHDRWNHAVRGETRIQRLDRNYGEILQ
                     ELRVAQTGVQLLLAFLLTVAFTPRFASFTVFQRDVYVASLVLGAAANALLIAPAAFHRM
                     VFRQRLKEQLVRYANRFALCGLALLMLALTSALLLILTVVLGMHAGSWLTGGALAWFVF
                     FWYLLPLWSRLRARR"
     misc_feature    10382..10384
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gcggcacgcc accggccacc cgggtggccg caccggtctt cggagcggcc acgctcaccc
       61 tttcccgagt gctggtcgcc gccatccttg gtgtgatcac cttgctggtg tcgcggcgcc
      121 tgcgctggcc aggccgcagg tacgttccgg ggctgctggt catgggcctc ggcctggccg
      181 gtggctaccc gctgtttctc gcccttgcgg tgcaacgagt accggcctcc cacagcgccg
      241 tggtgatcgg gctcgtaccg gctgccactg gtgtgctggc cgcgatccgc atcggggaac
      301 gacaacgagc ccggttctgg gcagcgtgcc tcatcgggtt cgccgccgtc ctcaccttcg
      361 cgctcaccca gggcggcgga aaactggacg ccgcggacct gtggctggtg gccgccgtgc
      421 tcagttgcgg gatcggctac gtcgagggcg ccaaggtggc cagggacatc ggtgcggtcc
      481 cgacgctgtg ctgggccatg atcctgctgg cccccgccgc cgcgatcgcg ctcgtggccg
      541 ccgcgccact gccaccggcc agctccgttc cggccggagc gtggatcggg ttcggctacg
      601 cctgtctggt cagcatgttc gtcgggtcgg tgctctggta ccgaggactc gcggccgggg
      661 gaaccgcccg catcggccag ctcaacctcg cgcaaccgtt cctggccatc gcctggtccg
      721 gtctgctgct gcacgaacgg atcacctggg ccgtggcggt caccgccgcc gtcatcgtcg
      781 tctgcatgac cgtctgcgtc cggtcaccgt ccgccccgcg attacctact gggcgaatac
      841 agggtcgcgg gtgcccggta gttttaacga acgtatccga gctgatgagg actaccggtg
      901 aagatggaca acagccccgc caggggtact cgtgacctgc tgcccgcgac cgtcgccgtg
      961 cgcgatcatg tcctggcccg gatcaccgag gtctaccacc ggtacggcta ccagcgaatc
     1021 gagacgcccg cgctggagga catcacgcgg ctgaccggcg gccagggcgg cgagaacgag
     1081 aagctgatct tcaagatcct ccgccgcggc ctgaccgagt tccccgcgag catggacgaa
     1141 ctggccgacc tcgggctgcg gttcgacctg acggtcccgt tgactcgctt ctacggcaac
     1201 aaccacgcgt cgttgccgac gccgttccgg tcgttccaga tcggcccggt ctggcgtgcc
     1261 gagcggccac agaaggaccg ctaccggcag ttctaccagt gcgacatcga cgtgatcggc
     1321 gaggagtcgg tgctggccga ggccgagctg atcgaggcga cgaccgaggc cctggaggct
     1381 gtcggcctgc ccggcacgac cgtgcgcctg tcggaccgcc ggttcctgtc cgcgctggcc
     1441 gagggcgccg gggtggcacc ggaggcgcag ggctcgttct tcatcaccct ggacaagctg
     1501 gacaagatcg gctgggacgg ggtccgcaag gagctgaccg aacgggccgg gttcaccgag
     1561 gcgcaggccg acggcgtgca gacggcgatc acggcgttgc agggcctcga ccccgccaag
     1621 ctggccgacc aactggccga cgccgtgccg aacctgccgg agggcgtcgc ggcggacctg
     1681 gcggcgacca cgacggcgct cgccgagctg gccacgaccc gggagctcgg ctgggagttc
     1741 gacccgacgc tggtgcgtgg catgggctac tacaccgggc agatcttcga ggtgagccac
     1801 cccggcacga gcgcttcggt ggccggtggc ggccgctacg acaagctgat cggccgctcg
     1861 ctgggcaagg acgtgcccgc ctgtgggttc tctatcggtt tcgagcggat cgtgaacctg
     1921 ctcgacaacg ctccgcgcgt ggacgctgtc gccgtgctgc acgaggcgga cgtcaccccg
     1981 gcggaggtgc tggcggtggc gcggcggctg cgcgcggaag gtcgccaggt cacggcgatc
     2041 aagcggcgcg gcaagttcgg cgcgcaactg ggcagactgg cggaatgggg gttcacctcc
     2101 atggtccacg tcaaacccgg tgaagtggct gacgagcggg ttttgggcag ccgggaatca
     2161 agctgaccgg ctacggtgtt gaacatggca gtgaacgcgt cccctgatga gcccgcgtca
     2221 cagcggtttc gcgaggacct cgagggtctt gacccgcatg accccgaggt acgcgagttt
     2281 gcagcccacc tcgaccggat cgagaagagc cggtcggggt acaccgtgga gggatacctc
     2341 ggtggcatct cggacttcgc ggactcggcg aaccgcctcg gtggccacta ccggatgctc
     2401 gccctgctcg tgatctgcct gatcctggtc ggggtggtcg tcgccgcgtg ggacaccctg
     2461 gtgctcatcc tgaccagcct cggaggctaa gtgtccaaga agcccgtcac cggtgtcacg
     2521 cctcgcgtgg tcaagtccga ccaggagtgg cggcagcagc tgaccgccga ggagtacgcg
     2581 gtgctccgca aggccgggac cgagcgcccc ttcaccggtg aatacaccga tacgaagacc
     2641 gtcggcgtgt acgcgtgccg ggcgtgcggc gcggaactgt tccgtagtgc cacgaaattc
     2701 gattcgcatt gcggctggcc gtcgttcttc tcaccgctgg ccggtgacac cgtcatcctg
     2761 cgtgaagacc gcgacctggg catggtccgc accgaggtgc tgtgtgcgac ctgtcacagc
     2821 cacctcgggc acgtgttcga gggcgagggc tatcccaccc cgactgacca gcggtactgc
     2881 atcaacagca tctcgctgac gctgcgtccc ggcacggatg cggacgaaga agcctaagtt
     2941 acccccaaca catccctaaa tcttcctcaa ggcgtcttgc cgggtgccct tccggcgaag
     3001 aaagtggtgt ctccacttga tttccggctc tccctggaga gagggggaag atcatggaag
     3061 acccttgggg aatcgcaggg ccgacgttcg tcggcattta cctgctcggg ttttcgatcg
     3121 cattgctgtt cgcgttcgcc gtccgcattc tcacccgctc gggtgcggca accaccgcac
     3181 ccgtcgagtc gctgacggcg ctggagttgg ccgggttgac cggcgggccg ccgcgggtgg
     3241 tcgaggccgc catcgcacaa ctggtggaaa acggcgggct gcgcgctgcc cgtgacggat
     3301 atctgcaggt cgtcggcctg ggcgggggca gcaaccccgt tgagcgctct gtgctggccg
     3361 atgtgacgcg gcacggccgc aggtccatca ccatgctgac ctaccggctg gccaggtcgg
     3421 acgcggtcgg cgaggtgatg gcgggtcttg tccgctcggg gtatctcgtg gacggcgagg
     3481 tggcccagcg tcgcaaggcg gtcagcatga tcccggtcgc cgccgtgttc gctgtggggg
     3541 tgttgcggtg gctgtcgggg atcgcggccg accgtccgat cggctggctg acggtgttgc
     3601 tgatcgggag cgggctgatc gggtatttcc tgtaccgcca ggcgatctgc ccgaggacgt
     3661 tcgccggagt caacgcggtg gaacgcgtgt cggcgagcga accggtcgac ctggtggcgg
     3721 caggaggttt cgccagccac ccggaccgaa ccgtcaggga gtcactgctc ggcgggcagt
     3781 accaccggct cagccggacc gggatgctcg gcggcgcggc ctggtggctc ggtagcggcg
     3841 gtgccggttc cacaggaggc ggcggtgccg gttgcggagc gtcgggagga agcagcggct
     3901 gcgggggtgg cggctgcggg ggttagaaaa agaaatgagg gaggcggacc ggcccgggga
     3961 tcacgatccc cgggccggtc cgtacacaga ggggagagga catgggcaac ccttggggta
     4021 tctcgggacc ggctttcctg tggctgtatt ccggtggcct cgtgcttgcc gggatcatca
     4081 cactggcatt gcggcggcgc gcctggtcga ccggcacggc gaacctgacg gagccgctga
     4141 cggtcgacga gatggcgttc gcggcaggtg gccggaccag gatggtcgag tcggcgatcg
     4201 ccaacctggt ggatcacggc gcggtccgca tcgaacgcag cgggcagttg cacgcggtcg
     4261 ccgagtcgcc gtaccggccc gagtcggagt tggaggagcg actggttggt gacatcaccc
     4321 agcgtcccgg ccggatgatg gactactacc agcgccgagc gatgcgcctg ccgctgtacg
     4381 accaggtccg ggacggcctc gaacggcgtg gcctgtacgt ccgtgacgtc ggccgcggcg
     4441 cgctgttcct cgccgcgtcg ccactggccg tgctgctggt gatcggcgtc gtgcgggctg
     4501 tcaacggcgc cagcctcggg tatccgatcg gatacctgac gatgttgatc atcctcacgg
     4561 gtgtggccct cggcttcgcc ctgcgccccg tcaggcgcgg ccctgtcccc caggcccgca
     4621 aggtcctgcg cggcggcggg cacaccggca ccagtgcggc ggccctggtc gccaggggcg
     4681 gaatggtcgc gtacccggat ccgttgatct cccagctgtt ccgggcgccg cagcggcgta
     4741 ccgcggcgca gtcataccgc cgtgccgggc agcccgccgg atcagcgggt ttctccctgg
     4801 gcggcggttg ttcctccggc ggcggcagca gttgctccgg tggtgggagc agtggcggcg
     4861 ggggctgcgg cggaggagga ggttcctgaa cgatgcgtcc agacgagatc gaggcctacg
     4921 ctgtgcccgg acgttcagga gcaaggcgaa ctcactgggc agcaacgact acagcgcgtg
     4981 tgggacggga ggattcggca gtggacgacc tcggtgtggg aatcggctgg cggccggaga
     5041 tcgacatcac ggtggaacgg ctgtccggcg tcgactttgt cgaggtcgtc gcggagaacc
     5101 tcgaccccgg ccacctgccg gagtccattg tggtgctcag ggaacgcggt atgccggtgc
     5161 tgccgcacgc ggtgtcgctg tcggtcggcg gcgcggaacc cgttgacctg aaacgagtcg
     5221 agcacctggc caagctggcc gacgtactgg gcgcgccggt ggcgagtgac catgtctgct
     5281 tcgtgcgggc gggtggcctc gactccgggc acctgatgcc ggtgccccgt accaaggagg
     5341 cattggacgt cctcgtcgac aatgtgaaaa tcgtgcagga caacctgaac gtgcccttcg
     5401 cgctggagaa catcgccgcg ctgctggaat ggccggacgc cgagctgacc gaggcgcagt
     5461 tcctcggcga actgaccgag cggaccggct gcctgctgct catcgacgtc gcgaacatgt
     5521 acgccaacgc ccgaaacctc aaccaggatc cggaaaaact actcgacgga ctgccgttgg
     5581 agcgcctggc gtacgtccac gttgcgggcg gcgaggaaca ccacggcgtc taccacgaca
     5641 cgcacaccca cccggtgctg ccggaagtgc tggacctgtt gtcggaactg gtgaagcgca
     5701 ccaggccacc gggtgtcctg ctggaacgcg acggcgacta ccccaccgac gccgaactcg
     5761 cggccgaact gcgggcgatc agggaacggc tgtgacccgg acatgacaca gccgcaacgg
     5821 gatcagctcg ccgagcagca ggcgcgactg cttcgggcgc tgctcgcgga cggcccgccg
     5881 ccaccaggtt tcgatccgca gcggctgcgg gtcgaggcga ccgcgttgcg atcgaaacgg
     5941 cggcgagtcg tggcgatgat ccagccggac gtgtgcgccg accttgagga cagattcgtc
     6001 ccgctgttca ccgagtacgc caaggcacac ccgaggacgg tgggatcgcg cgcgcgggag
     6061 gatgccgcgg cgttcgtgga atggctgcgg gagcacggac atctgccgaa gctgaagtgg
     6121 tggcgcaggc gtgcaacgaa aaacgggtga acggcgtccc actggtgtga cccggaatct
     6181 cgccgccgcg atcgcgctgg ccgccgcagc gctcgtattc gccgccgtcg cgctgacggc
     6241 gcgcgacccg cgtgtaccct gccctctgat cggcagccgg tccggtatct cgctggaggt
     6301 cgacccggcg tacgggccca ggatcggcac agcccggttg accacgtgct ggaattccgc
     6361 ctgcaccacc acaagcctga agctgtcccc gtcgagcaca tcagtcccca tgccgtgcac
     6421 cccgggcggg ccggacaacg cctgcgcgcg catggagccg accagcggca agtactcctt
     6481 cgccgagctg gcgaacctgc ccacctcgcc ggtcgaggtc acggttgacc tgatcgaccc
     6541 gaccggtgtc accctgtcgt cgccacgctt ggtgatcaca ccgacactcc agagttcggg
     6601 tggacccgaa tgcggaagcc ccacgccaca gggtggccta ctcgttgcgg ccaatggggc
     6661 gctcagcgag gatctgtaaa cagtccgtga ttgaacgctg gggaaattta ctatcgagtt
     6721 tgtcccaatg gggccttgtc actccatggt gtcaccgata gcttgcgttg accacggagt
     6781 gtggttcatc gactcctcac cgtcgatgtc tggggtgtgc gcagaaaacc cgatcgggag
     6841 gtttttcagg tgcattcagt caacaaccga gccgcgagac gtgtgggcgt cggggctctc
     6901 gtcctggggg tcgcgctcag cacggcgcag gtttccgctg cggccgaagc gcgagtcagt
     6961 caacaagacg gccgatccgt cactctcatc accggcgacc gagttgtcgt cgtcgacgcc
     7021 gcgtacaacg cgcgcagcat cgtgcccggc aagggccgcg agaaggtcgc gttctcgacc
     7081 tacaaacgcg acggtcacct cttcgtcatc ccgcaggacg ccgtttccct tgtcgcacaa
     7141 ggacgtctcg acgagcgcct gttcgacgtg acaacactgg ccgagtccgg ctacgacgac
     7201 gcccaccggt cgaccctgcc cctgatcgtc agccacgccc ctggcgcgcg gatcgcgggc
     7261 gccaggacca cggcgaacct gcccgcgctc aacgcatccg cgctcgccgc cgacaagacc
     7321 ggcgccgcgt ggcagtcact gaccgccgga aacgtcaaga aggtctggct cgacggcaaa
     7381 cgcacggcct cgctggaccg cagcaccgca cagatcggcg cccctgccgc gtggcaggcc
     7441 gggtacaccg gcgaaggcgt gaaggtcgcc gtgctggaca ccggcgtcga ccagacccac
     7501 cctgacctga ccagccgcga gaccgccgag cagaacttca ccgacgccgc cgacaccgtc
     7561 gaccgggtcg gccacggcac gcacgtcgcg tccaccatcg cgggcaccgg cgccaaggca
     7621 ggcggcaagt acaagggtgt cgcgtacggc gcgaacatta tcgacggcaa ggtgctcaac
     7681 gacaacggca gcggctacga ctcgtggatc atcgcgggca tgcagtgggc ggtcgaccag
     7741 ggcgccaagg tcgtcaacct gagcctcggc ggcccggaca gtcccgacaa cgacccgctc
     7801 gaagaagcag tgaacacgtt gtccgccaag aacggcacgc tgttcgtgat cgccgcgggc
     7861 aacagcggcc ccggcgccga gagcatcagc tcgccgggta gcgcggacgc cgcgctgacc
     7921 gtcggcgccg tcgaccgcga ggacggcctg gcgccgttct ccagccgtgg accgaggatc
     7981 ggtgacgccg ggatcaagcc ggacatcacc ggacccggtg tcggcatcgc cgcggccaag
     8041 gcagccaacg gcaggctcgg cacgccggtc gtcgacgggt acgtctccat gtccggcacc
     8101 tcgatggcca cgccgcacgt cgccggttcc gcggcgctgc tcgcgcaggt gcacccggac
     8161 tggaccggtg agcagctcaa ggcgacgctg accgcgtccg cgaagccgaa cgcgaagctc
     8221 aacgcgttcc agcagggctc gggccgggtc gacgcggcca aggcgatcac gcaggcggtg
     8281 accgcgtcgc cgtccagcct cagcctcggc acgcagccat ggccgcacga cgacgaccag
     8341 ccggtgtcca agggcgtgac gtaccgcaac accgggaaga ccgacgtcac cttcgacgtg
     8401 aaggtcaacg cgatcggccc ggacggcaag accccgcccg ccggtctgct gaccgcgtcg
     8461 cccgccaagg tgaccgtgcc cgccggtggc gaggcgaagg tgaccgtcac ggccgacacc
     8521 aggatcgaca cgctcgacgg cgtctactcc ggaacgctca ccgcgacttc cggtgacagc
     8581 ggcgtcagca ccccggtctc ggtcaaccgt gagccggaga gctactcgct gaccatcaac
     8641 cacatcggac tcgacggtgc tccggcgagc aactaccgca cgtcgatgtt cggtttggac
     8701 agcatgaaga tgagctccgc ctacgacgcg gacggcagcg cgacgatccg gctggccaag
     8761 ggccgctaca ccatcgacag ctcgctgctc ggcgaccaga tcaactggct gtcgttcccg
     8821 agcttcacgc tcaccgagga caccacgatc gatctggact tccggcgcac caagcaaacc
     8881 aaggtggccc cgccggaccc ggccgccgag ctgacactcg ccgacctgac ctaccaacgg
     8941 accgcgggca agggctcgtt cggctacggc tgggtgctgc tcggcggtga cctcggcagg
     9001 atgtacaccg ggcacgtcgg cccggaggtg cccccgcagg agctgctctt ccaggtcaac
     9061 acccagtggg acaccccgac cggtgagtac tacggactgg cgtactacca gtacggcacg
     9121 attcccaccg gtttcaccag ggcaccgaag aaggaccagc tggcacacgt gcacgcctcg
     9181 ttcggctcgc ccgcggccga ccggtccggc ctgcggtacg cgttcccgta cccgaagttc
     9241 ggcgagggcc cgggtgcgtg ggcgacgctg ctgccggtga agctgccggg tgaccgcacc
     9301 gagtactact cgaccgagga cacggcgtgg agccccggtc tgtggcagat gtccccggac
     9361 gagagcgaca tcgaggtcga cctgaccagt ccggtgaagg tgctgcaggc gggcaggacg
     9421 tatgaggagt cctacaaccg cggcgtgttc gcaccggccc tgccgcagac ccgcagcccg
     9481 tggcagtacc tcgtccgctc ggagaacaag atcacggtga acgtcccact gttcggggac
     9541 gccgccggga actccgggtc gtctcttgtg gacagttcgt cgaccgtgct ctaccgcgac
     9601 ggcaagaaga tcggggaaag caaggatccc ggctatggtc agttcaccgt cccagccgac
     9661 acgggaacgt acacactgac caccgaggct gtccgcagtg gtgtctcgga cgtctcgacc
     9721 gcggtccgcg ccgcgtggac gttccgctcc ggcccggtcg gcacggaccc ggtccgcctg
     9781 ccgctgtcca ccgtgcggta cacgcccgcg ctggacgcga cgaactcggc tccggccggt
     9841 gagtcgttca tcgtgccggt gtccgtccag gcgcagaaca gcaaccaggg cacggtgccc
     9901 aagtcgctga gcgtcgaggc gtcgttcgac ggcggccaga cgtggacggc gacaacggtc
     9961 gtggccaacg tgttcgccat cgtccagcac ccgaacgacg ccacctcggt gtcgctgcgg
    10021 gccaaggcga ccgacagggc gggcaacacc gtcgagcaga ccatcatcaa cgcctacaag
    10081 ctcaactgat cacccgctga accacatccc aacccgcgaa gcgccccggg gccaccccca
    10141 ctccggggcg ctttgccctt ccgatctacg tcaaccgacc gatgtctccc gttcaccttc
    10201 gagccatcgt gtattcatgc acccccagca caccgcccag cacagggccc agtcgcggac
    10261 gccggacgcg gaccacgacc gctggaacca cgcggtccgc ggcgagaccc gaatccagcg
    10321 gctcgaccga aactacggcg agatcctgca ggagctgcgg gtggcccaga ccggggtgca
    10381 gttactgctg gcattcctgc tgaccgtggc cttcaccccc aggttcgcca gcttcacggt
    10441 cttccagcgc gatgtctacg tcgccagcct cgtgctcggt gccgcggcca acgcgctact
    10501 gatcgcccca gccgcgttcc accgcatggt gttccgtcaa cgactgaagg aacagctcgt
    10561 ccggtacgcc aaccgcttcg cgctgtgcgg gctggcgctg ctgatgctcg cgctgacgtc
    10621 cgcgctgctg ctcatcctga ccgtcgtgct cggcatgcac gcgggctcat ggctgaccgg
    10681 cggcgcgttg gcgtggttcg tgttcttctg gtacctgctg ccgctgtgga gcaggctacg
    10741 cgcccgtcgg tagaacactt accgcatcgc ggatccggcc gtgggtttca accgc
//
