LOCUS       NZ_JHEG04000001        22039 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Tolypothrix bouteillei VB521301 NODE_1_length_9494340_cov_10.278967,
            whole genome shotgun sequence.
ACCESSION   NZ_JHEG04000001
VERSION     NZ_JHEG04000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Tolypothrix bouteillei VB521301
  ORGANISM  Tolypothrix bouteillei VB521301
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Tolypothrichaceae; Tolypothrix.
REFERENCE   1  (bases 1 to 9494340)
  AUTHORS   Chandrababunaidu,M.M., Singh,D., Sen,D., Bhan,S., Das,S., Gupta,A.,
            Adhikary,S.P. and Tripathy,S.
  TITLE     Draft Genome Sequence of Tolypothrix boutellei Strain VB521301
  JOURNAL   Genome Announc 3 (1), e00001-15 (2015)
   PUBMED   25700407
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9494340)
  AUTHORS   Sarangi,A.N., Mukherjee,M., Ghosh,S., Singh,D., Das,A., Kant,S.,
            Prusty,A. and Tripathy,S.
  TITLE     Improved Assembly of Tolypothrix boutellei genome
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9494340)
  AUTHORS   Sarangi,A.N., Mukherjee,M., Ghosh,S., Singh,D., Das,A., Kant,S.,
            Prusty,A. and Tripathy,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-NOV-2019) Computational Genomics Lab, Indian Institute
            Of Chemical Biology, 4, Raja, S. C. Mullick Road, Jadavpur, Kolkata,
            West Bengal 700032, India
REFERENCE   4  (bases 1 to 9494340)
  AUTHORS   Tripathy,S., Sanghi,N., Chandrababunaidu,M., Singh,D., Panda,A.,
            Gupta,A., Das,S. and Adhikary,S.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAR-2014) Computational Genomics Lab, Indian Institute
            Of Chemical Biology, 4, Raja, S.C. Mullick Road, Jadavpur, Kolkata,
            West Bengal 700032, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: NOV-2019
            Assembly Method                   :: SPAdes v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000760695.4-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 03:45:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,181
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,922
            CDSs (with protein)               :: 7,922
            Genes (RNA)                       :: 97
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 164
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 164
            Pseudo Genes (frameshifted)       :: 41 of 164
            Pseudo Genes (incomplete)         :: 132 of 164
            Pseudo Genes (internal stop)      :: 36 of 164
            Pseudo Genes (multiple problems)  :: 40 of 164
            CRISPR Arrays                     :: 25
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:00:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6919376
            Orig. end                         :: 6941415
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JHEG04000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22039
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="spliceotide"
                     /product="RRE-containing"
                     /region_number="23"
                     /rules="(TIGR04103 and TIGR03798)"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..22039
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04103 and TIGR03798)"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="neighbouring"
                     /product="spliceotide"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21820
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(TIGR04103 and TIGR03798)"
                     /kind="single"
                     /product="spliceotide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21820
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11820](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04103 and TIGR03798)"
                     /neighbourhood="10000"
                     /product="spliceotide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11820
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04103 and TIGR03798)"
                     /neighbourhood="10000"
                     /product="spliceotide"
                     /protocluster_number="1"
     misc_feature    complement(170..184)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.95"
                     /tool="antismash"
     cand_cluster    1827..22039
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1827..22039
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11826:12039](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11827..12039
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
     gene            2222..4030
                     /locus_tag="HC643_RS28105"
                     /old_locus_tag="DA73_0400028060"
     CDS             2222..4030
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="other (smcogs) SMCOG1272: TPR
                     repeat-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF021616.4"
                     /locus_tag="HC643_RS28105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028060"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_038090398.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.9e-26,
                     bitscore: 91.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVTEALQLAIQHHQANCLDQAEQCYRQVLAEQPDRLEALHGLS
                     IVAQQTGQFHYAEELLKAALDFQPNSVKTWFDLGNLHLSQSRFAEAVESYHHALALQPN
                     LVPIYNNLGYALQQMDQWEKAIACYQKALDLQPKCAEAEANLGNALFAQGKLSSDEQTY
                     YAQLNHKLGEIRERAGDLKTAEAYYRQARELAPEEGQYYINLGKIYQQQKDFSQAIAVY
                     REGLKRLNPRYAEAVATYQSPETIPVTPPVTFGEVTVGAYQFPTIPLVANPEKPRPFWS
                     VIIPVYNRIDYLLEALASVLMQWQGEEEMEILVMDNGSTTPLFEMVNSIGGGVIRYYRN
                     PENLGVITNHNIGIALSRGRWIHVLHDDDCVLPGFYSRLQQSLEACPDSIGVACTGFEY
                     INEDGKTIQPGEVVSLYGEHRGIMHSWLSHIGVCGLVTIPAMVVRRTTYERLGGYYPEL
                     PEIADWEIFKRFAAFCDWWYEPGILACYREHTQRMSPENMRSGKMARAIRRAIEVSETY
                     LPAEHRIEITAKARHHNFHYCLSRASLPLKAGNLTGALHVLQETLKIDSSPQAVANLFA
                     WLTQDELAPLREEIVSRLFSLPVNSV"
     gene            4176..5495
                     /locus_tag="HC643_RS28110"
                     /old_locus_tag="DA73_0400028065"
     CDS             4176..5495
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015116553.1"
                     /locus_tag="HC643_RS28110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028065"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_167844765.1"
                     /transl_table=11
                     /translation="MNKKTITNNQKSYGGCLFCSSELNHTFVDLGMSPPCESYRSLEQL
                     NEMEPFYPLHAYVCEKCFLVQLQEYIRPENIFSDYAYFSSYSQTWLQHAKNYVDMAVER
                     FQLNYKSQVVEIASNDGYLLQYFVSKDIPALGIEPAANIAEVAIKKGIPTVVKFFGEET
                     AREQLAKGKQADLLIGNNVLAHTPYLNDFVKGLKILLKEQGVITMEFPHLMRLKEENQF
                     DTIYHEHFSYFSFITVEKIFAFHGLTIFDVEELSTHGGSLRIYARHNEDFSKPITQKVL
                     ELRHREETSGVTNLDYYSSFSEQVKETKRKLLDFLIKVKREGKSIVGYGAPGKGNTLLN
                     YCGIRTDFLDYTVDRSPYKQGLFLPGTHIPIFHPDKIQETKPDYVLILPWNLKDEIMVQ
                     MSYIRDWGGQFVVPIPEVQILLNNRSFNKNLSFEKRRYKK"
     gene            5492..6289
                     /locus_tag="HC643_RS28115"
                     /old_locus_tag="DA73_0400028070"
     CDS             5492..6289
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015116552.1"
                     /locus_tag="HC643_RS28115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028070"
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="WP_038090396.1"
                     /transl_table=11
                     /translation="MKVVLFCGGLGTRIRDYSETIPKPMVNVGYRPILWHVMKYYAHYG
                     HKDFILCLGYKADTIKSYFLNYNEWISNNFTLSNGGDIKLFNRDIQDWNITFVDTGLTA
                     NIGQRFKAVEEYLEGEDVFLANYSDGLTDLHLPTYIDHFYKIDKIASFLCVRPSQTFHL
                     VDLDEQGLVRDIKDVKHRDIWINGGYFIFKKEVFQFINQGEELVLEPFQRLIKREQLFA
                     YKYTGFFGVMDTFKEKQQLDDMYARGERPWEVWRDKQLEVSRA"
     gene            6340..6939
                     /locus_tag="HC643_RS28120"
                     /old_locus_tag="DA73_0400028075"
     CDS             6340..6939
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015116551.1"
                     /locus_tag="HC643_RS28120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028075"
                     /product="PIG-L deacetylase family protein"
                     /protein_id="WP_237265957.1"
                     /sec_met_domain="PIG-L (E-value: 3.2e-15, bitscore: 55.8,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAHCDDIEIGCGGTILKLIEKYQNIILYWVVFSSNEQREKEARD
                     SANTFLKEVQTKKVLVKNFRDGFLPFHGLDVKECFEQLKKEFSPDIIFTHYRDDRHQDH
                     RLISELTWNTFRNHLILEYEIPKYDGDLGIPNFFVHLDEALCCRKIQYIQDAFISQKNK
                     QWFTEETFRSILRIRGIESNSPSQYAEGFYCRKIFF"
     gene            6971..8302
                     /locus_tag="HC643_RS28125"
                     /old_locus_tag="DA73_0400028080"
     CDS             6971..8302
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015116549.1"
                     /locus_tag="HC643_RS28125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028080"
                     /product="DUF4910 domain-containing protein"
                     /protein_id="WP_167844766.1"
                     /transl_table=11
                     /translation="MPEAELSKTITFSYDESDDNSMGNELYQFICKLYPICRSITGNGT
                     RKTLQLLQEDIPLKIHEIPTGTQVFDWTVPKEWNIKDAYIKNSKGEKILEFANSNLHIL
                     NYSIPIHKKVNLQELTDHLFTIPEHPTWIPYRTSYYKETWGFCLTHQQYLELQDDEYEV
                     FIDSSLEPGYLTYGEYFIPGESSDEVLISCHICHPSLCNDNLSGIAIAVSLAKHINQVT
                     PYYSYRFLFIPGTIGSITWLALNEINVSKIKHGLVLTCLGDAGKFTYKKSRRGDTEIDK
                     IVTYILNNTTKDSKVIDFFPYGYDERQYCSPGFNLAVGCLMRSPHGSFPEYHTSADNLD
                     FIQPQYLADSLSKCISILSILDNNKIYLNQNPKCEPQMGKRGLYKAVGGYKNDELNQMA
                     LLWVLNLSDGHHTLLDIAQKSGITFDEIKYAADALLKHDLLKIL"
     misc_feature    complement(6997..7008)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            8342..8578
                     /locus_tag="HC643_RS28130"
                     /old_locus_tag="DA73_0400028085"
     CDS             8342..8578
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS28130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400028085"
                     /product="hypothetical protein"
                     /protein_id="WP_038090389.1"
                     /transl_table=11
                     /translation="MERKQVIFKRIVSPDGKTIVDLRSIAKTSGDGQNEIHQNWSVEDN
                     QIQASQNISVNISSSGHSAKSSQAASISINKHQ"
     misc_feature    complement(8377..8392)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.26"
                     /tool="antismash"
     gene            8772..9137
                     /locus_tag="HC643_RS28135"
                     /old_locus_tag="DA73_0400028090"
     CDS             8772..9137
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS28135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400028090"
                     /product="hypothetical protein"
                     /protein_id="WP_038090386.1"
                     /transl_table=11
                     /translation="MIISDLSHLETTFEDAAIIGGSNGILFVVGETAYDKLKILSATGT
                     ISIKELLKNGVIAKGKGFVIALGSDLIDATATVSVSGDAEGTKTVIKAEGYSADNSTSA
                     ISISQITVKPITLASPS"
     gene            9179..9454
                     /locus_tag="HC643_RS28140"
                     /old_locus_tag="DA73_0400028095"
     CDS             9179..9454
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015216094.1"
                     /locus_tag="HC643_RS28140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028095"
                     /product="hypothetical protein"
                     /protein_id="WP_038090383.1"
                     /transl_table=11
                     /translation="MEDNKISNHQMEINDLIDLAITNAAIRRGLVEGEDCLALSDDEAT
                     KVTGGATISTDVKSINTKTPPTVAGFKPICPPLIVGLIAQDYNKLA"
     gene            9504..9974
                     /locus_tag="HC643_RS28145"
                     /old_locus_tag="DA73_0400028100"
     CDS             9504..9974
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748602.1"
                     /locus_tag="HC643_RS28145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028100"
                     /product="hypothetical protein"
                     /protein_id="WP_038090488.1"
                     /transl_table=11
                     /translation="MEDITPKQTTLCPSARPESVNGVVFGIVAGTAIAPRIAYLKKPLP
                     VTDELMAKATGSVTPAEIFRTAASCAESGCQHFDGKDCRLSMRIVEKLPAVVEELPPCS
                     IRRNCRWWQQEGKAACMRCPQIVTDNYSSSEQLRQAANPATDPSINFQSSLE"
     gene            10001..10423
                     /locus_tag="HC643_RS28150"
                     /old_locus_tag="DA73_0400028105"
     CDS             10001..10423
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     spliceotide: TIGR03798"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748601.1"
                     /locus_tag="HC643_RS28150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028105"
                     /product="Nif11-like leader peptide family RiPP precursor"
                     /protein_id="WP_038090381.1"
                     /sec_met_domain="TIGR03798 (E-value: 1.2e-08, bitscore:
                     33.8, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLEIFEKVKDFLVKLVKDEAFRTQLMSGKAEEVKKALENGGYNF
                     SQQEFETAAIQILELKELGEFHELSEEELVGAFGGITSINDRVIQPLYGVIYWPPKGCL
                     KPCIKPKPIDPQPMYGIVIDPPVQALYGVVAPSELQ"
     gene            10555..11820
                     /locus_tag="HC643_RS28155"
                     /old_locus_tag="DA73_0400028110"
     CDS             10555..11820
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     spliceotide: TIGR04103"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748600.1"
                     /locus_tag="HC643_RS28155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028110"
                     /product="nif11-class peptide radical SAM maturase 3"
                     /protein_id="WP_038090379.1"
                     /sec_met_domain="TIGR04103 (E-value: 1.1e-245, bitscore:
                     813.5, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 3.6e-47, bitscore:
                     159.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.6e-22, bitscore: 78.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-06, bitscore: 27.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-12, bitscore:
                     46.7, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 0.00012, bitscore: 21.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYHRKSYAVWEITLKCNLACSHCGSRAGNTRSKELSTEEALDLV
                     KQMAEVGIKEVTLIGGEAFLRPDWLEIAKAINEAGMLCGMTTGGYGISLETARKMKAAG
                     IRTVSVSIDGLEETHDRLRGRKGSWKYAFQTMRHLREVGISFGCNTQINRLSAPEFPCI
                     YECIRDAGARAWQIQLTVPMGNAADNADILLQPHELLDIYPMLARVARRAYQEGVQLQA
                     GNNIGYYGPYERLLRGRGNEHEFSFWQGCGAGLSTLGIEADGAIKGCPSLPTTAYTGGN
                     IREHSLHDIIENSAQLRLNLGAGTPEGTKHLWGFCKTCEYAELCRGGCSWTAHVFFDRR
                     GNNPYCHHRALVYQERGLRERVIPKVKAQGLPFDNGEFELIVEPISTPLPENDPLNFCA
                     DNIQWSESWQNKPEISYSLMEQ"
     aSDomain        11827..12021
                     /aSDomain="PlpY_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Discrete RRE protein in an alpha-keto
                     beta-amino acid containing peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HC643_RS28160_PlpY_RRE.1"
                     /evalue="8.00E-26"
                     /identifier="RREFam029.1"
                     /label="HC643_RS28160"
                     /locus_tag="HC643_RS28160"
                     /protein_end="65"
                     /protein_start="0"
                     /score="80.8"
                     /tool="antismash"
                     /translation="MENIEILKIQEKNTDVDSSFDELEKTPLLPRSAWNRQLSHLKEVF
                     KAKQALDKIEQIYKDSKNLK"
     gene            11827..12039
                     /locus_tag="HC643_RS28160"
                     /old_locus_tag="DA73_0400028115"
     CDS             11827..12039
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PlpY_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748599.1"
                     /locus_tag="HC643_RS28160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028115"
                     /product="hypothetical protein"
                     /protein_id="WP_237265958.1"
                     /sec_met_domain="PlpY_RRE (E-value: 2.2e-23, bitscore:
                     80.8, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENIEILKIQEKNTDVDSSFDELEKTPLLPRSAWNRQLSHLKEVF
                     KAKQALDKIEQIYKDSKNLKESKYS"
     gene            12536..12892
                     /locus_tag="HC643_RS28165"
                     /old_locus_tag="DA73_0400028120"
     CDS             12536..12892
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS28165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400028120"
                     /product="hypothetical protein"
                     /protein_id="WP_038090373.1"
                     /transl_table=11
                     /translation="MIISDLSHLDILSEDDAILGSAGATVSTNATASGDYTQTKAVTKS
                     FALPLGNNGSLAIGIGYAQASAVDSQDASAVTSVSGSANGDINFVIGKNYSTDNGPRAR
                     AGGVVLAVGIDIPG"
     gene            complement(13077..13940)
                     /locus_tag="HC643_RS28170"
                     /old_locus_tag="DA73_0400028125"
     CDS             complement(13077..13940)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS28170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400028125"
                     /product="hypothetical protein"
                     /protein_id="WP_038090371.1"
                     /transl_table=11
                     /translation="MRTINPHLQRAKHFLLFATPAIAGSVLAVSPSYAATFATSQGESL
                     YINFSQKPFLTDSVADTDTLAVSKQGLVNAFADAQAGFLTEPSFASTSSLSTALGETRN
                     YLGLAKSETIVRGFFNVEANTPFRFDFTANLDLETSIDNPPGENARAAGDIFLALVDTE
                     RERVLDFFSLVGNLNTLGDDDFLALDKSENITFLEPESEYNYSFGGNNEFITASVKGSL
                     NREITQDTVLALVEIRRNQAKVQAPEPSSILALLAPSAVVSLVLKGKRKGKSLESSSES
                     KVSAEV"
     misc_feature    14097..14112
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     misc_feature    complement(14199..14212)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    complement(14238..14252)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.93"
                     /tool="antismash"
     gene            15355..15945
                     /locus_tag="HC643_RS28175"
                     /old_locus_tag="DA73_0400028130"
     CDS             15355..15945
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748593.1"
                     /locus_tag="HC643_RS28175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028130"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_050046781.1"
                     /transl_table=11
                     /translation="MKNVDKKIAIDGQVCYKFLTPFQRKILIKNLQTNLQPEYRRRLEI
                     MLMADQGKSQTQICEILGCSKEMARYWSTVAKAGLAHKWQEQPKGRPKTVNDQYIERLK
                     ELVRYSPREYGYGFDTWTAQWLSKHLAQELGIEISDRHINRLLKKMGLSKKQKSSSNKA
                     VRNQPKDAAIAIDDLQSNVEPSFHWSFNLIQHN"
     gene            16346..19141
                     /locus_tag="HC643_RS28180"
                     /old_locus_tag="DA73_0400028135"
     CDS             16346..19141
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017314975.1"
                     /locus_tag="HC643_RS28180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028135"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_038090359.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.7e-42, bitscore:
                     141.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSEFSLQQLGQQLISILGEKLPEQELASYQTMVEIVEPPAAKQF
                     WHSTNTHTGIYIVLTGKVRLLDSSGNLISTLEVGASFGEVTLFPNENFSPYAARASYNL
                     KLCYLNKQILQILISKYPNIQAHLLARAESWERLLNSYQQEADTSYQDVSMTSGLKIDE
                     RKSHDYTSVPITERRKVIPFPSQTIAQPKQKRSRVYFPNPKVRVGQIWGRLTRRYPFFE
                     QQSLADCGVACLVMIARYWGKRLSVNRLRELANVNRSGASLRALAAAAESIGFSTRPVK
                     ASFDKLAEQPLPAIVHWEGKHYIVVYEITSKYVIVGDPAVAQRKLSHAEFKRGWTGYAL
                     LLQPTARLKESQEASTPFWQLFELVKPHTTVLVEVFLASVFIQVFGLVTPLFTQLLLDR
                     VIIQGSTITLTAIGLGLVIFGLFRVAMNGLRQYLLDHTANRVGVSLLVGFIKHTFRLPL
                     AFFESRYVGDIISRVQENQKIQRFLTGEALSIILDLLTVVVYIGLMFWYSWQMALLVLL
                     VIPPFFLLALITTPLLRRINREVFNALSEENSYLIQSLTGIRSIRSMAIEQTVRWRWEE
                     LLNQLIKKMFGAQVVANQLQIFSSTIESLATTGLLWFGAWLVIQNQLSIGQLVAFNMLL
                     GNVIHPFQRLTVLWNQLQEIVVATERINDVLDAEPEEDLLLSPRQSLPRLCGHIRFENV
                     TFRYHPESDTNILENINFEIQPNQTVAVVGRSGSGKTTLSKLILGLYPPTTGKVSIDGH
                     DVANISLKSLRSQMGVVDQETFLFGGTIRENISIAHPEATLEEIVEAARLAGADEFIRQ
                     LPLGYETQIGEGGGMLSGGQRQRLAIARALLGNPQFLIFDEATSHLDAESERIIQNNLK
                     TILKGRTSLIIAHRLSTIRDADLILVLDQGILIESGTHDELVAKKGHYYYLNQKQLTQA
                     G"
     gene            19321..20862
                     /locus_tag="HC643_RS28185"
                     /old_locus_tag="DA73_0400028140"
     CDS             19321..20862
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748591.1"
                     /locus_tag="HC643_RS28185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028140"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_038090357.1"
                     /transl_table=11
                     /translation="MANLSNNSSSTFSPSEERQITDTALNSVKEARPVKEHSSDWFYGT
                     EELLDALPKRWTRSLLYMLVVFSAIALPWAMFSKVDETGSARGRIEPLGAAQRLDTQVS
                     GSVTAVKVKEGELVKAGQVLVELESDVLKTDLQQTRAKLEGQKNRLAQQNLLKNQLLLA
                     ISVQQQQNQSQELEKIAQLNQAKQNLDAKQSTYNLLKLEKLALVDQAKQNLISTQTVHN
                     LATIRWNRDLKEVQRYQKLLQKGAIAEIKIVELEKAAEESQRLHEQTQSDIKQARLRLA
                     EEQNRYQTIMRQAQADIEQAKLRLVEQQSSYKSVLHTGKLALLKNQEQLKDLQTQITSL
                     RSEIAQTNSQITSLKLQLEQRIVKSPVDGVIFELPIEKPGAVVQPGQMIAQIAPKESPF
                     VLRASIPSQNTGFLKVGNKVKIKFDAYPFQDYGVVSGRVSRISPDSKLQDTNQGKMETF
                     ELDITLDSFDIQTGNKRIPLTPGQTATAEVITRQRRVIDFILDPFKKLQKGGLEL"
     gene            20962..21747
                     /locus_tag="HC643_RS28190"
                     /old_locus_tag="DA73_0400028145"
     CDS             20962..21747
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017748590.1"
                     /locus_tag="HC643_RS28190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400028145"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_038090355.1"
                     /transl_table=11
                     /translation="MLSCLNISLNDILFQLKVSYQMPGLIEAIAARKIIMNSAREAGIQ
                     VDITSLQQAADSLRLANNLLKAEDTWAWLQKHHLTLEEFEQLAETNLLSAQLANHLFAD
                     KVEPFFYEHQLDYLAAVTYEVVLDDEDVACELFYALIEREISFQEVARKYIKNPELRRA
                     GGYRGVRYRTNFPAEIAALVFAANPPQLLKPIVTSQGVHLLSVEEIIQPELNQQLHFKI
                     MTDLFSAWLKEQIAEIEIVTQFEPDSSYSQTVPELLKLA"
ORIGIN
        1 tcttccatgg aagccagaaa atttgctggt actgcagcga tcgcagatat tttcctagat
       61 agcattggtt ggtctggatg caactcaact ttagaagcga tcgctcacaa cgtaccagtg
      121 gttaccttcc caggggattt gatgcgggga cggcatacta tggccatact gaaaatgatg
      181 ggcatagaag aaacgattgc tgccactaaa gaagaatatg tgaaaattgc agtgcttttg
      241 ggtcaagatg ctcaataccg tcaatatatc tctcagcaaa ttgcggagaa caagcacaag
      301 ttatataacg acttaaaacc agtcagagca ctagaagatt ttctttttaa ggtgttgaat
      361 aagccaagac gatttagctc tcaagaagtc gctgaaatgt tccaacttgc agttcaacat
      421 catcaagcaa atcgcctagc tgaagcaaag cacctctatc atcaagttct ggaaaaacaa
      481 cccgagcatc ccgagacttt atacagttta ggtataatag cgcagcaatt gggacaactt
      541 caaacagccg agcagtggct aaataaagca tcacgagtac aaccagattc tgttaagact
      601 tggttcagtt taggaaattt gcatttcgct caacagcagt attctgaagc agcgatcgct
      661 tacagtcaag ctttagcctt acgaccagat tcactcccaa tttataataa cttgggctac
      721 gccctgcaac aacaaggact atttgacgaa gccgttcgtt actatcagaa agctttagag
      781 ttgaagccag acttcatcga agccgaggca aatttgggaa atgcattgtt tgcccaagga
      841 aagctgtcct cggacgaaca aacttactac gcacaattaa atcacaagtt gggagagatc
      901 cgggaaagag caggcgattt gaagacggcg gaagcttact atcgtcaggc tcgagaactt
      961 gctcccgaag aaggacaata ttacatcaac ctcggtaaga tctaccaaca gcaaaaagat
     1021 ttctcccaag ccatagctgt ttatcgcgag ggattaaaac gcctcaatcc ccggtatgca
     1081 gaagcagtcg ccacctacca aagcccggaa accattcccg taaccccacc cgtcacttta
     1141 ggagaagtca ctgttggagc atatcaattt cctgccattc ctcccgtagc caaccccgag
     1201 caaccgcgcc cattctggag tgtggtaatt cccgtttaca atcgcattga ctatctactc
     1261 gaatctttgg caagcgtgtt gatgcaatgg caaggggaag aggagatgga aattttggtg
     1321 atggataatg gcagtacacc gcctctattt gaaatggtca acagtcttgg gagaggagtc
     1381 atccgctact acagaaaccc ggaaaatctt ggtgttatca caaatcataa tataggcatt
     1441 gccttgagtc ggggtcgctg gattcacgtg cttcatgacg atgattgtgt tcttcccggt
     1501 ttttattctc gcctacaaca aaatctagaa gcgtgtcctg attctgtggg agcagctttt
     1561 acaggttttg aaaatatcaa tgataaaggg caagcgattt tcacccaaca agtgtatgga
     1621 gagtacagag gtatagttca tcaagattgg ttacaaaaga ttggagtctc caacccatta
     1681 aatatgcctg cggtggttat tcgtcgagat gctcacgaac ggttgggagg tttctctcct
     1741 cagttgacat atactcctga ttgggaatta tacaaacgta ttgcttcttt ttacgattgg
     1801 tggtacgaac cgggcatttt agcacgttat cgagaacatt ctaacaatat cactactaac
     1861 cttttactaa ctcaaaatca gggaaaagat atccgtcatg caattgaaat ttcagacagc
     1921 tatttaccag tgagcgatcg cgcaacgatt accgcccgct ctcgcagcca ttactgggat
     1981 tattatatga agcaagccgt ctttgtacta caagcaaacg atgttgctgg tgctttccaa
     2041 atgcttcatg aggctctcat aatagatagc tcttctgtcg ctgtcgcaaa gttatttact
     2101 tggctgactc aaaacgaaac gtctttgcta gggaatgaga ttgcctcaag attaatctca
     2161 ctgccattga atgagagcgg agcaaaagtt tgaacatcgt tattacttaa caaaacttga
     2221 tatgacaagc gttaccgaag ctcttcaact tgcaatccaa catcatcaag ccaactgtct
     2281 cgaccaagcg gagcaatgtt accgtcaagt actcgcagaa cagcccgatc ggttagaagc
     2341 attgcacggg ctaagcattg tagcacaaca aacagggcag tttcattatg ctgaagagtt
     2401 actgaaagct gctttggact ttcaaccaaa ctcagtcaaa acttggttcg acctcggtaa
     2461 tttgcatctg tctcaaagtc gttttgctga agccgtagaa tcttatcatc acgccttagc
     2521 tctgcaaccc aacttagtac caatttacaa caatttgggt tacgctttgc aacaaatgga
     2581 tcaatgggaa aaagcgatcg cctgttatca aaaagcctta gatcttcagc ccaaatgtgc
     2641 cgaagctgag gccaatttgg gaaatgcatt gtttgcccaa ggaaagctgt cctcggacga
     2701 acaaacctac tacgcacaat taaatcacaa gttgggagag atccgggaaa gagcaggcga
     2761 tttgaagacg gcggaagctt actatcgtca ggctcgagaa cttgctcccg aagaaggaca
     2821 atattacatc aacctcggta agatctacca acagcaaaaa gatttctccc aagccatagc
     2881 tgtttatcgc gagggattaa aacgcctcaa tccccggtat gcagaagcag tcgccaccta
     2941 ccaaagcccg gaaactatcc ccgtgacccc acccgttact ttcggagaag tcactgtcgg
     3001 agcgtatcaa tttcctacca ttcctctagt agcaaaccct gaaaaaccgc gaccattctg
     3061 gagtgtaata attcccgttt acaatcgcat tgactatctc ctcgaagctt tggcgagcgt
     3121 gttgatgcaa tggcaagggg aagaggagat ggaaattttg gtgatggata atggcagtac
     3181 aacaccactc tttgaaatgg tgaattccat tgggggagga gtcatccgct attacagaaa
     3241 cccagaaaat ttaggtgtta tcacaaatca taatataggc attgccctga gtcgcggtcg
     3301 ctggattcac gtgcttcatg acgatgattg tgttcttccg ggtttttatt ctcgcctaca
     3361 acagagttta gaagcgtgcc ctgattcaat tggcgttgct tgtacgggtt ttgaatatat
     3421 caacgaggac ggaaaaacta ttcagcctgg agaagtcgtt tctttatatg gagagcatcg
     3481 aggcattatg cactcttggt tgtcccacat tggtgtatgt ggcttagtca caattcccgc
     3541 tatggttgtg cgtcggacaa cttacgaacg attgggagga tattatccag agttacctga
     3601 aattgctgat tgggaaattt ttaagcgctt tgctgctttt tgtgattggt ggtacgaacc
     3661 cggtatcctg gcatgttacc gcgagcatac ccaaagaatg tcacctgaaa atatgcgttc
     3721 tggaaagatg gcaagagcta tccgccgtgc aattgaggtt tctgaaactt atcttccggc
     3781 tgagcatcgg attgaaatta ctgccaaagc tcgccaccac aatttccact attgtttgtc
     3841 aagggcaagt cttcctctta aagctggaaa tttgactgga gctttacacg tacttcaaga
     3901 aacccttaaa atagactctt ctccacaagc agtggcaaac ttattcgcct ggttaactca
     3961 agatgaattg gctccgctgc gagaagaaat tgtttccaga ttgttctcat tacctgtcaa
     4021 tagtgtttaa aaatatttaa tagaggattg ctatatatag caatcctatt tgatttataa
     4081 acaatacttt tccctacccc ctgccctcat gaagtgtttg taattcaaat aggagctata
     4141 tgactttaac tacctatcat ctctcatcaa agtttatgaa caaaaaaaca ataacaaata
     4201 accaaaaatc ttatggtggc tgtctctttt gtagctctga gttaaaccat actttcgtag
     4261 atttaggtat gtctcctcct tgcgaaagtt atcgtagttt agaacagcta aacgaaatgg
     4321 agccttttta tccactccat gcttatgttt gtgaaaaatg ctttttagta caacttcaag
     4381 agtatattcg tcctgaaaat atctttagtg actatgccta tttttcctct tattctcaaa
     4441 cctggttaca acatgccaag aactatgttg acatggcagt agagcgtttt caattaaact
     4501 ataagagtca ggtagtagaa atagctagta atgatggata cttactacaa tactttgttt
     4561 ctaaagatat acctgcactc ggaatagagc cagctgcaaa tattgccgaa gtagccatta
     4621 agaaaggtat tcccacagtc gtaaagtttt ttggagaaga aacggcaagg gaacaattgg
     4681 ctaaaggaaa acaagctgat ttactaattg ggaacaacgt cctcgctcat actccctatc
     4741 tgaatgattt tgtcaaagga ttgaaaattc tactcaaaga acagggcgta attaccatgg
     4801 agtttccgca tttgatgcga ttaaaagaag aaaatcagtt tgacacgatt tatcacgaac
     4861 acttttctta tttttctttc ataactgtag aaaagatttt tgcttttcat ggtttaacta
     4921 tctttgatgt tgaagaatta tctacccatg gcggttctct aaggatttat gctcgtcaca
     4981 atgaagattt ttctaaacct attacccaga aagttttaga actaagacat agagaagaaa
     5041 catctggcgt tacaaattta gactactatt cttcttttag cgaacaagtt aaagaaacta
     5101 aacgtaaatt actcgatttt ttgattaaag taaaaagaga agggaaatcc attgtgggtt
     5161 atggcgctcc tggaaaagga aatactcttt taaattactg tggtatccgc actgattttc
     5221 ttgactacac agtagatcgt agcccttaca aacaaggttt atttttaccc ggaactcaca
     5281 ttcccatttt tcacccagat aaaattcaag aaactaaacc agactatgta ttaattttgc
     5341 cttggaattt aaaggacgaa attatggtac agatgtctta cattcgagat tggggtggtc
     5401 aatttgtagt tcccattcca gaagttcaaa ttttgcttaa caacagatct tttaataaga
     5461 atttatcttt tgaaaaacgg agatataaaa aatgaaagtt gttttgtttt gtggtggttt
     5521 gggaacgaga attagagact attcagaaac cattcccaaa ccgatggtta atgttgggta
     5581 tagaccgatc ttatggcacg tcatgaaata ctatgcccac tacgggcata aagattttat
     5641 cttgtgtctt ggttacaagg ctgacacaat taagagctat ttcttgaatt ataatgaatg
     5701 gatttctaat aatttcactt tatcaaatgg aggtgatatt aaattattta atcgtgacat
     5761 tcaagactgg aatattactt ttgtagacac tggtttaact gctaatatag gtcaaagatt
     5821 taaggcagtt gaagaatatt tagaaggaga agatgttttc ttagctaact acagtgatgg
     5881 cttgacagat ttgcatttac ctacttacat cgatcatttt tataaaattg ataaaattgc
     5941 gagtttttta tgtgtaagac caagccaaac ctttcactta gttgacttag atgaacaagg
     6001 tttggtacgg gatatcaaag atgttaagca tcgtgacatc tggattaatg ggggatactt
     6061 tatttttaaa aaagaagttt ttcaatttat taatcaagga gaagaactag tgctcgaacc
     6121 tttccaaaga ttgataaaga gagaacaact ttttgcttac aagtatactg gcttcttcgg
     6181 agtcatggat acttttaaag agaaacaaca attggatgat atgtatgctc gtggtgaaag
     6241 accttgggag gtatggagag ataaacaact agaggtatct cgtgcatgat aagcattagt
     6301 tttgataaag cagattgctc ggagtacaag attctttgtt tgggtgctca ttgtgatgat
     6361 attgaaattg gctgtggggg tacaatctta aagctgatcg aaaaatatca aaatattatc
     6421 ctttactggg tcgttttcag ttctaatgag caaagagaaa aggaagcacg tgacagcgct
     6481 aatacttttt taaaagaagt acagactaaa aaagtactcg taaaaaattt tcgagacgga
     6541 tttcttcctt ttcatggctt agatgtgaaa gagtgctttg agcagttaaa gaaagagttt
     6601 tcaccagata taatttttac tcactaccgc gacgatcgcc atcaagatca tcgcttaatt
     6661 tccgagctaa cttggaatac ctttagaaat cacttaattt tagaatatga aattccaaaa
     6721 tatgatggcg atttaggtat tcccaatttc tttgttcatt tagatgaagc attgtgttgc
     6781 cgtaaaattc agtatattca agatgcattt atctcacaaa agaataaaca atggtttacg
     6841 gaagaaactt ttcgttcaat tttaaggatt cgagggattg agtctaattc tccgagtcaa
     6901 tacgcagaag gattttactg tagaaaaatc tttttttaaa aaaggtttta catcattagg
     6961 aaattgacct atgcctgaag ctgagctatc aaaaacgata acattttcct atgacgaatc
     7021 tgatgataac agcatgggaa atgaacttta tcaattcatc tgtaagcttt atccaatttg
     7081 tcgcagcatt acaggaaatg gtactcgcaa aactctgcaa ctccttcaag aagatattcc
     7141 tttaaaaatc catgaaattc caacagggac tcaggttttt gattggactg ttcctaaaga
     7201 atggaatatc aaagatgctt atattaaaaa ttccaaaggc gaaaaaattt tagaatttgc
     7261 taactcaaac ctgcatattc ttaattacag tattccaatt cacaagaaag taaatcttca
     7321 agaattaaca gatcatttgt ttacaattcc agaacaccct acttggattc catatcggac
     7381 ttcatactat aaggaaacct ggggattttg cttaactcac caacaatact tggaacttca
     7441 agatgacgaa tatgaggttt ttattgattc ttcccttgaa cccggttatc tgacttatgg
     7501 tgaatacttt attcctggag aaagctcaga tgaagtgtta atctcttgcc atatctgtca
     7561 tccttcactt tgtaacgata atttatctgg aatagcgatc gcagtttctt tagcaaaaca
     7621 cattaaccaa gttacgccat actattctta cagatttctt ttcattccgg gaactattgg
     7681 ttcaattacc tggctagctt taaatgagat aaatgtatcc aaaatcaaac acggtttagt
     7741 tttgacatgt ttgggtgatg caggaaaatt tacttacaaa aaaagccgcc gaggcgatac
     7801 tgaaatcgat aaaattgtaa cttatattct taataacaca acaaaagatt ctaaagttat
     7861 agatttcttt ccttatgggt atgatgagcg acaatactgc tctccaggat ttaatttagc
     7921 tgttggttgc ttaatgagat cgccacacgg cagttttcct gaatatcaca catcagcaga
     7981 taatttggat tttatacaac cccaatacct tgctgattca ttatctaaat gtatatcaat
     8041 attatctatc ctcgacaata ataagattta tctcaatcaa aatcctaaat gcgaaccaca
     8101 aatgggtaaa agaggtttat acaaagcagt cggaggttat aaaaatgatg agctaaatca
     8161 aatggcactt ttatgggttt tgaatttgtc tgatggacat catacactat tggatattgc
     8221 tcaaaaatcc ggaataacat ttgatgaaat caagtatgct gctgatgcat tgctgaaaca
     8281 cgatttgtta aaaattcttt gagcttttga acacaacttg agtacaatag gtggtaaaat
     8341 catggaacgc aaacaagtta tatttaaacg gatagtttca ccagatggta aaactattgt
     8401 tgacctaaga agtattgcca agacatctgg cgatggtcaa aatgaaattc atcaaaattg
     8461 gtcagtcgag gataatcaaa ttcaggctag tcaaaatatt tccgttaata tttcatctag
     8521 cggtcactct gcaaaatctt cacaggctgc ttctatttct atcaacaagc atcaataaca
     8581 aaaacatgga tactctgtat cattcacatg gtttttgaat cttaataagt tcaaactgaa
     8641 aacaagacac caagccttaa tagctatctt tctcaccgac aagccagtta ataaaaactc
     8701 aagagttcag acacaaattg aactcttgag tatatttcaa tcaactttgt tttacacctt
     8761 acattttcac tatgattatt tctgatttaa gtcatctgga aaccactttt gaagacgctg
     8821 caattatagg tggtagtaat ggaatcttat tcgttgttgg agaaacagct tatgataagt
     8881 taaaaatcct tagcgcaact ggcacaatct ctattaaaga gttacttaaa aatggtgtta
     8941 tagctaaagg taaaggtttt gttatagcac taggctccga tctaattgat gctacagcta
     9001 cagtgagtgt ttctggagat gctgaaggta caaaaactgt aatcaaggct gagggttatt
     9061 ctgctgataa cagtactagt gcgatctcca tcagtcagat tactgtaaaa cccattactc
     9121 tcgcttctcc aagctaaaaa cacaatttcg gcttaattga atcacccagg atagacacat
     9181 ggaagacaac aaaatatcta accatcaaat ggaaattaat gacctaatcg atcttgccat
     9241 tactaatgcg gcgatccgaa gaggattagt agagggagag gattgtttag ctttatctga
     9301 tgacgaagct acaaaagtta ctggtggcgc gacaattagt acagatgtaa aatctataaa
     9361 cactaagact ccaccaacag tagcagggtt taaaccaatt tgtccgccgc ttatagtggg
     9421 actgattgca caggattaca ataaacttgc ttaatttttt gccttcaagt gttaaagatg
     9481 ctctttcaat ggaggctaaa ttaatggaag acattactcc caagcaaaca actctttgtc
     9541 ctagtgctag acccgaatcc gtaaatggtg ttgtctttgg catagttgct ggaacagcga
     9601 tcgcacctcg tatagcctat ctcaaaaagc ccctgcccgt tacagatgaa ctgatggcaa
     9661 aggctactgg atcggttaca cccgcagaga ttttccgaac tgcagcatcc tgcgcggaat
     9721 caggctgtca gcattttgat ggcaaagact gtcgtctatc aatgcggatt gtcgaaaaat
     9781 tgcctgcggt agtagaagaa ctaccaccct gttctatccg ccgaaattgt cgatggtggc
     9841 agcaagaagg caaagcagct tgtatgcgat gtccgcaaat tgtgacagat aactattctt
     9901 catccgaaca attacgtcaa gcagcaaatc ctgctacaga tccttccatt aattttcaat
     9961 cttcattgga gtaaaacctc attcccagga aagaatcatc atgtccctag aaatttttga
    10021 aaaagtcaaa gactttcttg tcaaactagt taaagacgaa gccttccgaa ctcaactcat
    10081 gagcgggaaa gcggaagaag ttaaaaaagc tctagaaaat ggtggctata acttttctca
    10141 acaagaattt gaaacagccg ctattcaaat attagagttg aaagaattag gtgagtttca
    10201 cgaacttagc gaagaggaat tagtaggagc ttttggtggt attacaagca tcaatgatag
    10261 agttattcaa ccattatacg gcgttatata ttggcctccg aaaggatgtc taaaaccatg
    10321 tataaaacca aagccaattg acccgcaacc gatgtacggc atagttatcg atccacccgt
    10381 acaagcgcta tacggagtcg ttgctccatc agaactacaa tagccctaag ctgacttatt
    10441 agggttgtca tttgtcattg gtcagtggtc attagttact ggtcactggt gacttatctt
    10501 taaattacaa acgacaaatg acaaatgaca aacgataaat aacaaataat tattatggca
    10561 tatcatcgca aaagttatgc agtctgggaa attactttaa agtgcaattt agcttgtagc
    10621 cattgtggtt cccgtgctgg aaatactcgc tctaaagaac tttcaacaga agaagcttta
    10681 gatcttgtca aacaaatggc agaagttggg attaaagaag ttactctcat cggtggtgag
    10741 gcatttttgc gtccagattg gttggaaatt gccaaagcta ttaacgaggc aggtatgtta
    10801 tgtggtatga ctactggcgg ttatgggatt tcattagaaa ctgcacgtaa aatgaaggca
    10861 gcgggaattc gcactgtttc cgtttccatt gacggcttag aagaaactca cgatcgcctg
    10921 cgaggaagga aaggttcttg gaaatatgct tttcaaacca tgcgccattt acgagaagtt
    10981 ggtatttcct tcggttgcaa cacccaaata aaccgcttgt cagcgcctga gtttccttgt
    11041 atctatgaat gcattcgtga tgctggtgct cgtgcatggc aaattcaact caccgtcccc
    11101 atgggtaatg cagccgataa tgcggacata ctccttcaac cccatgaact actggatatc
    11161 taccccatgc tagctcgtgt cgcccgtcgc gcctaccagg aaggagttca actccaagcc
    11221 ggaaataata ttggttacta tggtccttac gaacggctgt tacggggacg gggaaacgag
    11281 catgaattct cattttggca aggttgtggt gcagggcttt ccactctggg aattgaagcc
    11341 gacggagcaa tcaaaggttg tccctcatta cctactaccg cctacacagg tggtaatatt
    11401 cgagagcatt ctttgcatga cattattgaa aattcagcac aactgcgttt aaatctggga
    11461 gcaggaacgc ctgaaggcac aaaacatcta tggggtttct gtaaaacctg cgaatatgca
    11521 gaactttgcc gtggaggttg cagttggacg gctcatgttt tcttcgatcg cagaggtaat
    11581 aatccttact gtcatcatcg cgctcttgtt tatcaagaac gaggtttgag agagcgtgtt
    11641 attcctaaag tgaaagcaca aggactaccc tttgataatg gtgaatttga gctaattgtg
    11701 gagcctataa gtactcctct accagaaaac gatccattaa acttttgtgc tgataatatt
    11761 cagtggtctg aaagttggca gaacaaaccc gaaatttctt actcattgat ggagcaatag
    11821 ctcgtgatgg aaaatataga aattctcaaa attcaagaaa aaaacaccga cgttgattca
    11881 tcttttgatg aattagaaaa aactcctctg cttcctcgtt cagcttggaa caggcaatta
    11941 agccatttaa aagaagtttt taaagccaag caagctttag ataaaataga acagatttat
    12001 aaagattcta aaaatcttaa agagtcgaag tattcgtgat gaaaacttta ccatcaatat
    12061 gaaatctttc cttcccaaat gcatgggttt tattctctat ttccccaggg aagatgggat
    12121 tagaggatga ggtcaataaa gttttagcac atttaaagtg ctcactttga ctttgccata
    12181 atgaggatgc ttgaaaagtc atgattgatg gattaaatat tttttacacc accctaaccc
    12241 agagcttgca aaagggaggg aactaagttt ttcttatttc ccccctttcc tagaggggac
    12301 taaggggggt aataatgtat aaaaatggta actaaacact tttcaaatat cctcgttata
    12361 gcgaaataaa tttactaatt tttttaattt aaacaattct aaattttatt gaaattaaag
    12421 ttattatgaa ttactatttt aagtaatttc ttataaaaga aatacaaaat aattataata
    12481 aatatgtaat aataaaaatg ccaagatcga gaatttagga aaagtatttc tagctatgat
    12541 tatctctgat ttaagtcatt tagatattct ttctgaagat gatgcaattt taggaagtgc
    12601 tggagctaca gttagcacga atgctacagc ttctggtgac tatacccaaa ctaaggctgt
    12661 aactaaatcc tttgctctac cgttgggtaa taatggttct ctggctatcg gtattggtta
    12721 tgctcaagca tctgcagtgg attcacaaga tgctagtgct gtgacttctg tttccggatc
    12781 tgctaacgga gatatcaatt ttgttattgg gaaaaattat tccaccgata atggtcctag
    12841 ggctagagcg ggaggtgttg ttcttgcagt aggaatcgat attcctggat aaatgcgctt
    12901 aactaaaatc agacttgaga cgggtgcatc tcgcaaattt tcagagtcgc tatttgaatg
    12961 tattgtcaat gcgattgctg aagtttttgg actcataaac aaactttgcg atcgcactga
    13021 ctttcattaa aatgctgagg cacgaagcct catctcttga gtgcggggtg ctgacgttaa
    13081 acctctgcag acacttttga ctctgaagag gattctaaag attttccttt gcgtttaccc
    13141 tttaatacta agctaacaac tgcacttggc gcaagtaaag caaggatact tgaaggttca
    13201 ggtgcttgca ctttagcctg atttctccta atttccacta gtgctaaaac tgtgtcttga
    13261 gttatctctc ggtttaaaga acctttaaca gacgccgtaa taaattcatt gttgcctcca
    13321 aagctatagt tatattcact ttctggctca aggaaggtaa tattttcact tttatccagt
    13381 gcaaggaaat cgtcgtctcc aagagtattt aaatttccca caaggctaaa gaaatctaaa
    13441 acacgctctc gctctgtgtc aactaaggct aaaaatatat ctccagctgc tcttgcattt
    13501 tctccaggag gattgtctat tgatgtttct agatctaaat tagctgtaaa atcaaaacga
    13561 aagggtgtat ttgcctctac attgaagaag ccgcgaacta tagtttcact ttttgccaat
    13621 cccaagtaat ttctcgtttc acctaaggct gtacttaaag atgaagtaga tgcgaaggat
    13681 ggttccgtca gaaaccctgc ttgcgcgtca gcaaaagcat ttaccaaacc ttgctttgaa
    13741 acagccagtg tgtcagtgtc agctacacta tcagtcaaaa agggtttttg actgaagttg
    13801 atatagagtg attcgccttg agacgttgca aaggtagcag cataactagg tgatacggct
    13861 aatacagaac ctgcgatcgc aggagtcgca aacagcaaaa agtgctttgc tctttgtaag
    13921 tgtgggttta tagttctcat ctgtatgtaa ttttgaatgg atgcaaaact tggcaatctc
    13981 aacctgtaag ccaggaaaat acctagctca ctccgaacct attgccaaac aatttttctt
    14041 caaacaaaga atgcttgtat cagtctttat ggctaaaaga ctgtggtaaa tactatgtac
    14101 ccctgggagg tcaattttta cttacgtaac tatactactg ttctcaaact atgtctcgtg
    14161 taaactttcc ataatatatt gtcaaattta cacaaaagtt tttttatcaa atttttataa
    14221 actcatcaat ttaatacaaa tttctgaaat attgaggttg tagcgtcgaa tctacccccc
    14281 ttagtcccct agggctgttt cattttccaa agaaaaaacc tcaaactctt atttgtccgt
    14341 tctttacctg ggatagttca caaactggaa acgatgcttt gaggttttca agttttatct
    14401 acgaagaatg aaacagccct acccttggaa agggggaaaa ttaggattct cagttcctta
    14461 tacaaggaga aaatcgtctt ttcacgttat ctcaatagga atcagccatc cttaattttc
    14521 tttacctgta cagaatctcc aacagaggcg ttccctacag tgtatacaca agtctataat
    14581 acctagccga tataccgagg ttttagcgtt attttacgca atcctaaacc tccctttttt
    14641 aactacggcg tacacaaaag tctcctaaaa tgccttctga cagtttcgat ccccccctag
    14701 ccccccttaa aaagggggga aatttcttca agtcctccga taaattgggg ggttttgggg
    14761 gctctctaaa gatgcgtaca ccaccgtagc ccttttttaa gaagagaaaa tttttataca
    14821 accacatttt ttttatataa tttttatttt aaacttaata taaagagaat ttaaagattt
    14881 gatgaagatt gtttttttaa aggcagaaac ccttgactaa gtactaagaa gttttactat
    14941 tagtgaacag tagtttgata cacagactca agaaatgttg cttcgtcatt gaaattatct
    15001 ttcagggatt tcaaatttca tcagagtttg cgtattcaaa ccaattcttt aaggttgcaa
    15061 acaagagcca caattttggt acttaagggt aggctttgga accataaaga cttggtacac
    15121 tacgttttca catagctaat aatttgctgt agttattctt atatacagca atcctatttg
    15181 atttataaaa aacaagttga atggcattgc ctactaaaaa atacgatgtg ggcattgcat
    15241 accatacagt acctaaaatt gttgataaat aatttaggat tgctatattg atgtttttag
    15301 gaatattccc aagtgaaatt attcccaaca atggaagaaa accattagta aaacatgaag
    15361 aatgtagaca agaagattgc aatagatggt caggtgtgct ataaattttt aacacctttt
    15421 cagcgcaaaa ttctaattaa gaatttacaa acaaatttac agccagaata ccgtcgaagg
    15481 ctggaaatta tgttaatggc agaccagggg aaatcgcaaa ctcaaatctg cgagatatta
    15541 ggttgttcaa aagaaatggc gcgttactgg agcactgtgg caaaagcggg gctagcacat
    15601 aaatggcaag aacaaccgaa aggcagaccc aagacagtta atgaccaata cattgaaaga
    15661 ttaaaagaat tggtgagata tagccctcgc gagtatggat atggatttga tacgtggact
    15721 gctcaatggt taagcaaaca tctagctcaa gaattgggca ttgaaattag cgatcgccat
    15781 atcaatcgct tgctgaaaaa aatgggactt tccaaaaaac aaaaaagctc ttctaacaaa
    15841 gcagtcagaa accagcctaa ggatgcagcg atcgcgatcg atgacttgca atccaacgtt
    15901 gagccaagtt tccattggtc attcaattta attcagcata actagtacac gaaggcagaa
    15961 gtccgctcgt cagaggagcc actacagtgg acgggttcca caggcttcag caagtggtga
    16021 gtccagtcct acaggcggtg agaccagtgc tgcaggcggg tttcccgccg taagcgactg
    16081 gcgtatagcc ctgcgggcat agcttcgcat cgtggagcgt gtgcttgcac atagcgtctg
    16141 tgctcctgag atacgcgtaa gagcgtggca gaaggtgcca aagttttgat tgacagcttt
    16201 ttgcttgtta ctaatggttg ctttatttac gccaacctgt actagtcagt ggttagtaga
    16261 tagtcgtaag tcgttagtag ttaacaaata acaactaacc gctgaccact cacaattaac
    16321 cattaacaat taaccattaa ccaatatgtt atcagagttt tctttacaac aactcggtca
    16381 acaacttatc agtatcttag gtgagaaact tccagaacaa gaacttgctt cataccagac
    16441 aatggtagag atcgtagaac caccagcagc aaagcagttt tggcactcaa caaatactca
    16501 tactggaatt tatatagtcc ttactggaaa agtaagactg ctagatagtt ctggtaattt
    16561 aatttccacc ctcgaagtcg gagcatcatt tggtgaagtg actctttttc caaacgagaa
    16621 tttcagcccc tatgctgcta gagcttcata taacttgaag ctttgctatc taaacaaaca
    16681 aatcttgcaa attttaataa gtaaatatcc caatatccaa gctcacttgt tggctcgcgc
    16741 agaaagttgg gagcgacttc taaattctta ccaacaagag gcggacacat catatcaaga
    16801 tgtatccatg acttctggct taaagattga cgagcgaaaa agccatgact acacttctgt
    16861 tccaataaca gagcgaagga aagtcattcc atttccctcg cagaccatag cacaaccaaa
    16921 acaaaaaaga tcgcgtgttt actttcccaa tcccaaagtc agagtagggc aaatatgggg
    16981 acgactgacg cggcgctatc cgttctttga acaacaaagc cttgcagact gtggtgtagc
    17041 ctgcttggtg atgattgctc gctattgggg aaagcgcctg agtgtcaatc gattgcgaga
    17101 attagccaat gttaaccgta gtggagcctc tttgcgtgca ttagcagcag cagcagaaag
    17161 cattggtttt tctacccgtc ctgtaaaagc tagtttcgat aaattagcag aacaacccct
    17221 acccgcgatc gtgcattggg aaggcaaaca ttacattgtc gtgtatgaaa ttacttccaa
    17281 atatgtgatt gttggcgatc ctgctgttgc tcaacggaag ctgagccatg cagagttcaa
    17341 aaggggttgg acgggttatg cattgttatt gcaacctaca gcacgactca aagaaagcca
    17401 agaagcgagt acgccgtttt ggcagttatt cgagttagtc aaaccacata cgactgttct
    17461 agtagaagtc ttcttggctt ctgtgtttat tcaggttttt gggctggtca cacctttatt
    17521 tacacagttg ttattagacc gagtgattat ccaaggtagc accattacct taactgctat
    17581 tggtctgggc ttggtgattt ttggtttgtt ccgcgttgcg atgaacggac tacgacaata
    17641 tttgctggat cacacggcaa atcgagtagg agtctctttg ttggtggggt ttatcaaaca
    17701 taccttccgc ttacccttag ccttttttga gtctcgttac gttggtgata ttatttctcg
    17761 cgttcaggag aatcaaaaaa ttcagcgctt tcttacggga gaagcactgt ccataattct
    17821 tgatttgctt acagtagttg tttatatagg attgatgttt tggtatagct ggcaaatggc
    17881 attgctagtg ctattggtta taccaccctt tttcctatta gctctgataa ccacgccttt
    17941 actccgccgt atcaaccgtg aggtgtttaa tgctttaagc gaagagaaca gttatttgat
    18001 tcaatctctg acgggaattc gttctatccg gtcaatggca attgagcaaa cagttcgctg
    18061 gcgttgggaa gaactcctaa atcagttgat caaaaaaatg tttggcgctc aagtcgttgc
    18121 aaaccaacta caaattttca gttctaccat cgaatctttg gcaacgacag gattactgtg
    18181 gtttggagca tggttagtga ttcaaaacca actatccatc gggcaacttg ttgctttcaa
    18241 tatgctgttg ggtaatgtca ttcatccttt tcagcgtcta acagttctgt ggaatcaatt
    18301 gcaagaaatt gttgtagcca ccgagcggat taatgatgtt ctcgatgcag aaccagaaga
    18361 agatttactt ttatcacccc gccagtcctt accaagactt tgcggtcaca ttcgcttcga
    18421 gaatgtcaca tttcgctacc atccagaaag cgacacaaac atactggaaa acattaactt
    18481 tgaaatccag cccaatcaaa ctgtagcggt tgtggggcgt agcggttctg gtaaaactac
    18541 gctttctaaa ttaatcttgg gattatatcc tcccactaca ggtaaagtct cgatagatgg
    18601 tcacgatgta gctaatattt ctctcaaatc gctgcgttct caaatgggtg ttgttgacca
    18661 agagactttc ttatttggcg gtacgattcg agaaaacatc agcattgctc acccagaagc
    18721 cactctagaa gaaattgttg aggcggcgcg tttagcaggc gcagatgaat ttattcgaca
    18781 actaccactt ggctacgaaa ctcaaattgg tgaaggtggc ggaatgcttt ctggcggtca
    18841 acgtcagcgt ttagcgatcg ctcgtgcatt gttaggtaat ccccagttcc taatttttga
    18901 tgaagccacc agtcacctag atgcagaatc agaacgtatc attcagaaca acttgaagac
    18961 tattctcaaa ggacgtacta gcttgattat tgctcatcgc ctctctacca tacgcgatgc
    19021 tgacttgatt ttggtgttag accaggggat tttgatcgaa agcggtactc atgatgaatt
    19081 agtcgcgaaa aaaggacatt attactacct caatcaaaaa caactcactc aagcaggttg
    19141 agtcatttgt cactggtcac cgatcggttt tgttgggttt cgttcctcaa acgccacatc
    19201 gctcaacggg gggaaccctc cgcagttgct tcaacggggg gaacccccgc aacgcactgc
    19261 tctccacacg cgagtggctc cccaacctac ggtcacttcc tcattctcta tccccttcat
    19321 atggctaatc tatctaataa ttcatcatca acattctctc cctctgagga gcgacaaata
    19381 actgacacag ccctaaattc agttaaggaa gctcgtcctg taaaagagca ttctagcgat
    19441 tggttttacg gtactgagga actcttagat gctttaccaa aacgttggac gcgctctttg
    19501 ctgtatatgc ttgtggtttt tagtgcgatc gctttacctt gggcgatgtt ttcaaaagtc
    19561 gatgagacgg gaagtgctag aggacgtatc gaaccactcg gcgcagcaca aagattggat
    19621 actcaagtca gtggaagtgt cactgcggtt aaagttaaag aaggagaatt ggtaaaagcg
    19681 ggacaagttt tagtagaact ggagtcagat gtcttaaaaa ctgatttgca gcagacacgt
    19741 gcaaagctcg aaggacaaaa aaatcggttg gcgcaacaaa atttactcaa aaatcaactc
    19801 ttactggcta ttagtgtcca acaacaacaa aaccaatctc aagaattaga aaagattgct
    19861 caacttaatc aagcaaagca aaacctggat gcaaaacaaa gcacttataa cttactaaaa
    19921 ttggagaaac ttgctttggt tgaccaagca aagcaaaacc taatttctac ccagactgtc
    19981 cataacttag ccacaattcg ctggaatcgc gatttaaaag aagtccaacg ctatcaaaag
    20041 ctgttacaaa agggcgcaat tgccgaaatc aaaatcgtgg aactggaaaa agccgcagaa
    20101 gaaagccaaa ggttgcacga gcaaactcaa tcggatatta aacaagctcg gttgcgtctg
    20161 gctgaggagc aaaaccgcta tcagacgatt atgcgtcaag cacaagcaga cattgaacaa
    20221 gcaaaactga gacttgtcga acaacaaagt agttataaaa gtgtgcttca tactggcaaa
    20281 ttggctttgt tgaaaaatca ggaacaactc aaagatttgc aaacacaaat aactagcttg
    20341 cgttctgaga ttgctcaaac aaacagccag ataacatcct taaagcttca gttagagcag
    20401 cgaattgtta aatctcctgt agatggagtc atttttgaat tacctattga gaagccagga
    20461 gccgtagtgc aaccaggtca gatgatagcc caaatagccc caaaagaatc tccttttgta
    20521 cttagagcct ctatacccag ccaaaatact ggtttcttga aagtgggtaa taaagtgaaa
    20581 atcaagtttg acgcgtatcc ttttcaagat tatggagtcg tctccggacg tgtcagtaga
    20641 atttcaccag actccaaact tcaggataca aatcaaggca aaatggaaac ttttgaattg
    20701 gatattactc tagattcgtt tgatatccaa actggcaata aacgcattcc tttaaccccc
    20761 ggtcagacag caacagcaga agtcattact cgacaacgtc gagttattga tttcatctta
    20821 gatccattta agaagctaca aaaaggcggg ttagaacttt agcgattggt gagttgttaa
    20881 ttgttagtgg ttagtgggta tttgaacata aaaactggca accaaccact aacagcgtta
    20941 attttttgga ggaattgaat catgttaagt tgtttgaata tctcccttaa tgatatcctt
    21001 tttcagttga aagtttccta tcaaatgcca ggattaatag aagcgatcgc cgctcgtaaa
    21061 attattatga attctgctcg agaagcaggt attcaagtcg atataacctc actacaacaa
    21121 gcagcagata gcttgcgatt agccaacaat ttgctgaaag cagaagatac ctgggcgtgg
    21181 ctgcaaaaac atcatcttac tttagaggaa tttgaacaat tagcagaaac aaatctgttg
    21241 tctgcacaat tagctaacca tttatttgca gacaaagttg aacccttctt ttacgaacat
    21301 caactggatt acttggctgc tgttacctat gaagttgtct tagacgatga agatgtagcc
    21361 tgtgagcttt tttatgctct tatagagcgc gaaatcagtt tccaagaagt agcccgtaaa
    21421 tatatcaaaa atcccgaact acgtcgtgct ggtggatatc gcggtgtacg atatcgtact
    21481 aactttccag cggaaatcgc tgctcttgtc tttgctgcaa atcccccaca attactcaaa
    21541 cccatagtaa cttctcaagg tgttcatctc ttgagtgttg aggaaattat tcaaccggaa
    21601 ttaaatcagc aactgcattt taagattatg actgatttgt tttctgcatg gttaaaggaa
    21661 caaattgcgg aaatagaaat tgtcacgcag tttgaaccag attcttctta ttctcaaacc
    21721 gtcccagaac ttttaaaact tgcttaaaag tagtttataa aattcaatat gtatttacta
    21781 tggtgcgtta gcagaagctg aacgcaccat tgtctcactt tgcttgattt acctctccct
    21841 ctaaaaatac cgatttttgt aaaataggta gtgaacctta cgctttatgg taatttttta
    21901 acggaaagga aactatttga ttattccatc agcttcagat acgctcgttc aaaaacccgg
    21961 tttcttttat aagaaaccgg ggttttaaat tttacttctt tattttgagg actgatttgt
    22021 aacgatgagg taaatcaag
//
