LOCUS       NZ_JHEG04000001        20933 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Tolypothrix bouteillei VB521301 NODE_1_length_9494340_cov_10.278967,
            whole genome shotgun sequence.
ACCESSION   NZ_JHEG04000001
VERSION     NZ_JHEG04000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Tolypothrix bouteillei VB521301
  ORGANISM  Tolypothrix bouteillei VB521301
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Tolypothrichaceae; Tolypothrix.
REFERENCE   1  (bases 1 to 9494340)
  AUTHORS   Chandrababunaidu,M.M., Singh,D., Sen,D., Bhan,S., Das,S., Gupta,A.,
            Adhikary,S.P. and Tripathy,S.
  TITLE     Draft Genome Sequence of Tolypothrix boutellei Strain VB521301
  JOURNAL   Genome Announc 3 (1), e00001-15 (2015)
   PUBMED   25700407
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9494340)
  AUTHORS   Sarangi,A.N., Mukherjee,M., Ghosh,S., Singh,D., Das,A., Kant,S.,
            Prusty,A. and Tripathy,S.
  TITLE     Improved Assembly of Tolypothrix boutellei genome
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9494340)
  AUTHORS   Sarangi,A.N., Mukherjee,M., Ghosh,S., Singh,D., Das,A., Kant,S.,
            Prusty,A. and Tripathy,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-NOV-2019) Computational Genomics Lab, Indian Institute
            Of Chemical Biology, 4, Raja, S. C. Mullick Road, Jadavpur, Kolkata,
            West Bengal 700032, India
REFERENCE   4  (bases 1 to 9494340)
  AUTHORS   Tripathy,S., Sanghi,N., Chandrababunaidu,M., Singh,D., Panda,A.,
            Gupta,A., Das,S. and Adhikary,S.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAR-2014) Computational Genomics Lab, Indian Institute
            Of Chemical Biology, 4, Raja, S.C. Mullick Road, Jadavpur, Kolkata,
            West Bengal 700032, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: NOV-2019
            Assembly Method                   :: SPAdes v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000760695.4-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 03:45:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,181
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,922
            CDSs (with protein)               :: 7,922
            Genes (RNA)                       :: 97
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 164
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 164
            Pseudo Genes (frameshifted)       :: 41 of 164
            Pseudo Genes (incomplete)         :: 132 of 164
            Pseudo Genes (internal stop)      :: 36 of 164
            Pseudo Genes (multiple problems)  :: 40 of 164
            CRISPR Arrays                     :: 25
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:00:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3436569
            Orig. end                         :: 3457502
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JHEG04000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20933
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20933
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20933
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10933](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10933
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(352..368)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.86"
                     /tool="antismash"
     gene            complement(1062..1895)
                     /locus_tag="HC643_RS13690"
                     /old_locus_tag="DA73_0400013685"
     CDS             complement(1062..1895)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS13690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400013685"
                     /product="hypothetical protein"
                     /protein_id="WP_038073843.1"
                     /transl_table=11
                     /translation="MEDDNLSSLYDDVILNIRPQIQGLKRGILYKTIQILLEEEKSEIQ
                     EKTHLICEFLGIKANAYQIEDEKIVKSLVEVVFIKRQFLIRNTPCSGLIESFSKLVNQS
                     INNNEESMNWIIVTACTLVGVIYCQQYLSKNRHTQAKYKQKFEKVKQQVIPIEPVPADL
                     CLIVPASIAGNFKNGSNLTTDELINLIDNASYFLCTTLKNADLNEKKLEITEDFISSDS
                     KREVYMRIKIYDGKNLIDQKIPYYLKSNLPKHTLYIIEQLACLKNLSGLEKFNRV"
     gene            complement(1916..4384)
                     /locus_tag="HC643_RS13695"
                     /old_locus_tag="DA73_0400013690"
     CDS             complement(1916..4384)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012570.4"
                     /locus_tag="HC643_RS13695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013690"
                     /product="dynamin family protein"
                     /protein_id="WP_038073844.1"
                     /transl_table=11
                     /translation="MNTKLYKVFEDVEQNAKLLSKYWHNFSTEISEHLPDTYHPEVQEL
                     TEKLEKAIENLVNELQNPTLTLATTGTTSSGKSTLVNLLCGAEIVPVAVSEMSAGAVTI
                     EYSEKKSLIIHETPGALWECGEWTGISDERIYQRLYDVMISYIDNREKQPNLACPQSTI
                     SYPFRLIKESKLELPRGVKVRIMDLPGLAYVGDEGNANVIKQCREALCLVTYNSAETDQ
                     QKVRSLLQEVVEQVKDLGGSPARMLFILNRIDVFRADRNYPETENRFVENAIRSIKYEL
                     TEHLKEYTEDIEKLQVIKLSTWAALLALQIKNNDEIYSTEACKKADNHFNGLIDENILE
                     DLPRKVEKWSRHDRNRVADTLWQKSYAEEFQQGLRAHISQHFPRLVIPQAIERFNIAAG
                     NAVTEWALQTTTAFLNSSEERYQQECEKISWIRSTLETFLQISNQNLSKPFEEINAKVK
                     QVLANPSEDDPVFYLEKKLKEIQNIKPYTELGEKLYPLYGWRRELGKGLHQILEAVAKS
                     LETGKVDLDITYLNKANILNVNLLNKNLNRLINLGYTASIAKEGEIMEAKTELEKNKLK
                     QINEELNELSIHLNIVMEDVLKQIFNQELNRMYQAVVELFHCHLSYLEKEANKIAPHIA
                     ITFPESQIVKVEKHPTITFKFKAGFAITQGSWQEEKETIITLQEAHQRNTIGKSGWEWL
                     AGTIQGFVGDFVGKGVILQKKYIDYVQRSSDNAVIPSVRNLLEGWIDQADEEQREIVYQ
                     IVCWLLEQIDSLKRNVDKIQNNIIDRYQARLDRAKQDITLDYENNRKLWQPMQQKAQSI
                     IKDFKNLEKF"
     gene            complement(5120..5314)
                     /locus_tag="HC643_RS13700"
                     /old_locus_tag="DA73_0400013695"
     CDS             complement(5120..5314)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017742577.1"
                     /locus_tag="HC643_RS13700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013695"
                     /product="hypothetical protein"
                     /protein_id="WP_336604366.1"
                     /transl_table=11
                     /translation="MMKTIEDLKTRAKELSKQAVELRRKGSEVYESDPQQAKQYRQQAR
                     EAMKRCQVLIQEMKRQQAG"
     gene            complement(5511..5768)
                     /locus_tag="HC643_RS13705"
                     /old_locus_tag="DA73_0400013700"
     CDS             complement(5511..5768)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS13705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400013700"
                     /product="hypothetical protein"
                     /protein_id="WP_038073851.1"
                     /transl_table=11
                     /translation="MAIDKIRIKKYQQSKVEEWSQALDIPVTKFIEDAINFYTRYLDGK
                     QPVTIVEPVSQVSQNEQKLHPEVTVIDVEEPDDFDGGIEL"
     gene            complement(6599..7825)
                     /locus_tag="HC643_RS13715"
                     /old_locus_tag="DA73_0400013710"
     CDS             complement(6599..7825)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009458411.1"
                     /locus_tag="HC643_RS13715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013710"
                     /product="septal ring lytic transglycosylase RlpA family
                     protein"
                     /protein_id="WP_038073854.1"
                     /transl_table=11
                     /translation="MIFFGLLWVTSWIGSFLSLNQNLPPSLASNILPAKVSSNLGKLVN
                     KPLPFLIPDKQQMNVVGTTMLSRRFLKLDWGDKESKPNGTQPLAPLIKRDKNSKNQFCG
                     LQQENLAKQPAVKVASLLPVPSLIETGFDNRDFLPNQILRSLQNFFRLDNPIELGFDST
                     SAPAVVVHRGTSNYEVWLNNRIVANLPDRQQASLMQQRLTRLVKSSSFDASRLRPALVD
                     GIPALMSGNRFLFGIGKEVTRKTHRSADLLAIEWVNNLRQALQVPKLSLVEGQKEMYGL
                     TSSKKKMAGLASWYGPYFHGRMTANGETFNQNELTVAHKSLPFNTYLQVTNLKNGKTVI
                     VRVNDRGPYIPPRSLDLSRVAARCIDSELAGVVPYEAVILNKSEPRMTLKSLSLKMQKP
                     PRKLAVISE"
     gene            8578..10017
                     /gene="pds"
                     /locus_tag="HC643_RS13720"
                     /old_locus_tag="DA73_0400013715"
     CDS             8578..10017
                     /EC_number="1.3.5.5"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pds"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015083306.1"
                     /locus_tag="HC643_RS13720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013715"
                     /product="15-cis-phytoene desaturase"
                     /protein_id="WP_038073857.1"
                     /transl_table=11
                     /translation="MRVAIAGAGLAGLSCAKYLTDAGYTPIVLESRDVLGGLVAAWKDK
                     DGDWYETGLHIFFGAYPNMLQLLKELGIEDRLQWKEHTLIFNQPDNPGTYSRFDFPDIP
                     APWNGIIAILRNNDMLTWPEKIRFGIGLIPAMIQGQKYVEAMDRYSWREWMKKQNIPPR
                     VEKEVFIAMSKALNFINPEEISATILLTALNRFLQERYGSKMAFLDGSPTERMCEPMVE
                     YITSRGGEVRLNAPLKEILLNEDGTVKGYVIRGLHGASDEVVTADMYVSAMPVDVMKVM
                     MPEPWKQIEFFQKLEGLEGVPVINLQLWFDRKLTDIDQLLFSRSPLLSVYADMSNTCRG
                     YENPDKSMLELVLAPAADWIAKSDEEILQATLAELEKLFPDHFIGDNPTKLLKYHVVKT
                     PRSVYKATPGRQQHRPEQVTPVSNFYLAGSYTMQRYLGSMEGAVLSGKLTAQAIAEAHP
                     VAKSSSLQMQTLQPATNAATA"
     gene            10001..10933
                     /gene="crtB"
                     /locus_tag="HC643_RS13725"
                     /old_locus_tag="DA73_0400013720"
     CDS             10001..10933
                     /EC_number="2.5.1.32"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017320902.1"
                     /locus_tag="HC643_RS13725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013720"
                     /product="15-cis-phytoene synthase CrtB"
                     /protein_id="WP_038073860.1"
                     /sec_met_domain="phytoene_synt (E-value: 5.4e-97, bitscore:
                     323.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 6.8e-82,
                     bitscore: 273.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQLPDSPPRLKTLVSVDESYELCRQLTEKYAKTFYLATLLMSKV
                     KRKHIWAIYAWCRRTDELVDGPVAAITTPETLDRWEQQLKSIFAGQPTDNFDVALVDTL
                     QSCPMDIQPYRDMIEGQRMDLYRSRYQTFEELYLYCYRVAGTVGLMSTAVMGVDASNQS
                     APWYKSKPPYNPTEEAISLGIASQMTNILRDVGEDARRGRIYIPLEDLAKFNYTEQDLI
                     QGVIDERWRALMRFQITRTRQFYATAERGISYLSADARLPVWAALIHYSGILKVIERSD
                     YDVFNQRAYVPKLQKLSTLPVAWLRAQVL"
     tRNA            11050..11141
                     /anticodon=(pos:3447653..3447655,aa:Ser,seq:gct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HC643_RS13730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="DA73_0400013725"
                     /product="tRNA-Ser"
     gene            11050..11141
                     /locus_tag="HC643_RS13730"
                     /old_locus_tag="DA73_0400013725"
     gene            11402..12718
                     /locus_tag="HC643_RS13735"
                     /old_locus_tag="DA73_0400013730"
     CDS             11402..12718
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1282:
                     extracellular ligand-binding receptor"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016864968.1"
                     /locus_tag="HC643_RS13735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013730"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_038073863.1"
                     /transl_table=11
                     /translation="MKRTSTALALALLTTGVGFLTAACDTQAPQTPTTSSGNTTPGSSN
                     TTGSGSGLKIGSLLPATGDLSSIGQQMIPAVPFLVETVNACGGVNGQPVTLIQVDDQTD
                     PKAGAIGMTKLATVDKVAGVVGSFASSVSTAAVSIATQNKVMLISPGSTSPVFTEQAKK
                     GEFKGFWARTVPPDSYQGPALATLANKRGYKRVSTLVINNDYGVGFEQAFVRAFEKLGG
                     TVVNKNNPVRYDPKSTTFESEAAAAFGGKPDAVLGVFYVETGSLLLKSAYQQGLLQGVQ
                     VMLTDGMKSDEFPQQVGKTNDGKYIVTGVIGTVPGSNGKALDALTKLWQSKKGGSPGEF
                     APQSWDATALLVLAAQAAKENTGKGIANKIREVSNAPGVEVTDVCEGLKLLKEGKDINY
                     QGASGNVDVDANGDVIGIYNVWSVEADGKLKTIDKVSPQ"
     misc_feature    11419..11439
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 27.82"
                     /tool="antismash"
     gene            complement(12796..13668)
                     /locus_tag="HC643_RS13740"
                     /old_locus_tag="DA73_0400013735"
     CDS             complement(12796..13668)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017744693.1"
                     /locus_tag="HC643_RS13740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013735"
                     /product="hypothetical protein"
                     /protein_id="WP_038073906.1"
                     /transl_table=11
                     /translation="MNTIFFRKNAFCLLSLSAVALLGVSVPAVAQVADTANGEQLTLSS
                     GTEVSPQTTPVEVENFYPNVFTPSVQESSVPENTVASAGELNRVQPVQNHTQPETSNNV
                     VTPVPGTTFTSSAVLVTPQNTETQLKPSTSQVAQSDITTVDPGRRTRGGSSYIGIGGNI
                     GLGGDSALGDGNFMVLSKIGLTRVLSARPSVVIGDDTAILIPVTYDFSFRSIDPFSEPL
                     PIAPYLGAGVAIETSDDADVAFLLTGGIDVPISSQFTATAAVNAAFFDNTDVGLAIGIG
                     YNFGSLFGR"
     gene            complement(13902..14981)
                     /locus_tag="HC643_RS13745"
                     /old_locus_tag="DA73_0400013740"
     CDS             complement(13902..14981)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017312309.1"
                     /locus_tag="HC643_RS13745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013740"
                     /product="RuBisCO accumulation factor 1"
                     /protein_id="WP_038073871.1"
                     /transl_table=11
                     /translation="MTDLPPNVQEPNNNDVALELLRKLRQKQGNWVEWGIAIAQLQKLG
                     YNPQEIFEATGFEPVQQNQVTVGAQVYNSIEKVNAPAEVRSHYSTRGSDILYEFRLLTQ
                     EERTAAAELAFQNKIDVDGAKEIAKAIKEFSRFRTLPEGFENHPGDAVAYQAWKLARQN
                     TDLQERSRLIAKGLRFAYSQTARKQIEQLLTDFTVVPSRPAPSLPFYRLESEADLPRAI
                     PVVGELPLTQEDLQAVPLIEEIEPFRMVKFAGEQAWVPLPGWQVLLSAEDPVAILCKSG
                     KFPNQIQNPSEPVLVVVDRAQREWDSNSYFVVDNSGELDFQWFETSPEVPLLGRIIVIV
                     KPRRIVDENVTKDSWQIDE"
     gene            15270..16223
                     /locus_tag="HC643_RS13750"
                     /old_locus_tag="DA73_0400013745"
     CDS             15270..16223
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017744352.1"
                     /locus_tag="HC643_RS13750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013745"
                     /product="response regulator"
                     /protein_id="WP_038073874.1"
                     /transl_table=11
                     /translation="MNNPLPELDKIRRQLVNVESRRKAKMLVVDDEPDNLDLLYRTFRR
                     DFQVLKADSGVNALQVLASEGEVAVIISDQRMPEMKGTEFLSKTVPQFPDTVRIILTGF
                     TDIEDLVEAINAGQVYKYITKPWDPVELKAVVQRAVETYELLKQRTEELRRANAQMGLL
                     AVLVHVTQQASSLEAALDPIAKAFGDSFSADGCILQLVEGKALIAKQGTYSNGGSLENW
                     LDRDPLTTEAIANQQLQVSVNIPNDQKLAGVAHYQSNSVQAHLIIPITFREEVLAVLSL
                     QWKQPCTLREDELKLIHLSAQLVAMALITTRHYQPT"
     misc_feature    16348..16362
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.21"
                     /tool="antismash"
     gene            17213..18853
                     /locus_tag="HC643_RS13755"
                     /old_locus_tag="DA73_0400013750"
     CDS             17213..18853
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015140922.1"
                     /locus_tag="HC643_RS13755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013750"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_167844680.1"
                     /transl_table=11
                     /translation="MQKKSILLAENLGYELSATRVLFKGVHLSIAEKDRIALVGSNGVG
                     KSTLLKILAAQLNPTTGSITRQGTIYYLPQISTIKQESKAETVLDFLSSISEEWWDIEA
                     ILETQFNTNLDLSLPLFNLSGGELTKLFLAIGLAQQPKLLLLDEPTNHMDLMALESLKG
                     FLNNFEGAFVLVSHKPFFLDQVTEITWELTPEGIKVYGGHFSLYREQKETELEAALRSH
                     EVARKELKRAKASALQEQQRAAQSRKRGEQLAGSIPKIVAGMMKRKAEVTAGIAKQKHE
                     AIVEKATQKFTETKVRTAKATSIQLEERSQKRRNLIDIQGANLWVGESLLIKNIQLHLS
                     SGDRITVAGANGSGKSSLAKAILPKLATDDARYLTNKLSIELKDSSTAILASRSTTKAV
                     YLDQTYEIVNRTQTILENMQAANPNLSYQLLRQQLGHFLFKYDDVNKPASVLSGGELAR
                     LAIAIISISEIDLLILDEPTNNLDIETVNQMVESLNEYQGALWIISHDLDFLSRIDIHQ
                     AYKLSQQTLQMTTYLPSKPEQYYQELLTS"
     misc_feature    complement(18890..18909)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 20.47"
                     /tool="antismash"
     misc_feature    19166..19180
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.54"
                     /tool="antismash"
     misc_feature    19175..19191
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.98"
                     /tool="antismash"
     gene            19368..20411
                     /locus_tag="HC643_RS13760"
                     /old_locus_tag="DA73_0400013755"
     CDS             19368..20411
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024986.4"
                     /locus_tag="HC643_RS13760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400013755"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_050045762.1"
                     /transl_table=11
                     /translation="MKNIQYHTITLWKNYLNQLWFRVVIAFTIAYIIMVIASCIDKWSN
                     NQEFCRIKEPLQNCYFRQVISIFAPSNIEGFSILTVAILYILESQERRENRIYEAWQVV
                     DNASAAKVSTSYARIKALEDLNKYRVSLKGIDVPGANLSEINLRNADLKEVDFNDCIFS
                     NANLSNADLNGANLSDANLISANLSNANLFFATLNEANLSGANLNGATLFFADLNCADL
                     CNANLIGANLNSSILNNAILFSADLSNAQLWSANLSNTDLSDTNLSGANLKEANLSSAN
                     LSGANLKGANLSSANLQEANLSGANLSGANLKGANLSDADFRSVKSLEIEQIKSAKNWE
                     KALFDEL"
     misc_feature    20630..20645
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.25"
                     /tool="antismash"
ORIGIN
        1 agtcgcttgt ttatttaaag cttcctcatc attaattcca gttaaccttt gtaactgggc
       61 ttggatatta cctgcatcac caatctcgaa ctttgtctgt tctccagcta atccattcaa
      121 aagtagatat gccccagccg aaccgtatac aatacgttcc tgtggaagtc tcgcacgttt
      181 aaaccaatct tgagacgctt cttcaatatg agttttcagg gcttctgcac tacctaatga
      241 gtcaatacga cttaaaaata caaaaagttt atcagcaacg gtaatattct tgtcgccaag
      301 ttctgtaaat ttgataattt ctagttcttt ctctctcaag ctagtaaaac gctgtactaa
      361 tattacagca tcgcaatctg acagcattgc cttggcttcg tccacgtgct ttgctaaacc
      421 tgaatctaaa ccaggaacat cataaaatac aataccttca gcttgagcaa gtttgttagt
      481 ataaagtctt gcttctaaaa cagcatgagc atacttttca tcagctacat atttcttgag
      541 cgattccttg atatcttcta gacgagtaaa tggaaaaata cgattacctt ctcttcttac
      601 ttgctgtaag gtaatttcat tatttcgtat agtattaata tcttcttgcg cgtttacttt
      661 ctgaagttcg tttaagagat taataaattg ttcttcagtt tttgcctgta cttccagctt
      721 ttgctctgtg tcattctgaa ccgaataaat ttgcgttgtt gtaaatgtac accttcctcc
      781 cttagctggg agtaaatcgc attctaacca agcattgata aaagtacttt ttcccgcttt
      841 ctctaaaccg acaactgcaa tgcgaaactc tcgctttctc agtctctcaa gttgacggcg
      901 tgctggttct gcttcttgca atagtatttc ttttaattgc gagggaacct cagcttgagg
      961 taaattagct aaattaattg cgtatcgctg tacgtttagg gcttcagtta gacgagcctc
     1021 gtagtaggaa gatgctgttt tccaatccat ttatataatc cttatacacg gttaaatttt
     1081 tctaaaccag acagattttt taaacaagcc aactgttcga taatatataa agtatgtttt
     1141 ggtaaatttg attttaaata gtatggtatc ttctgatcga taagattttt tccatcataa
     1201 atcttaattc tcatataaac ttcacgctta ctatcagaag aaataaagtc ctctgttatt
     1261 tctaattttt tttcattgag atcggcattt ttaagagtag tacataagaa atatgaagca
     1321 ttgtctataa gatttattag ttcatcagta gttaagtttg aaccattttt gaaattgcca
     1381 gctatagatg ctggaacaat aaggcagagg tcagcaggaa cgggctcgat aggaataact
     1441 tgctgtttta ctttttcaaa tttttgttta tattttgctt gtgtatgtct atttttacta
     1501 agatactgct gacaataaat tactccaact aatgtacaag ctgtcacaat aatccaattc
     1561 atgctttcct cattattatt aatagattga ttaactagct tggaaaaact ttctattaac
     1621 cctgaacagg gtgtatttcg tatcaggaac tgtcttttaa tgaaaactac ttctactaaa
     1681 cttttaacaa ttttttcatc ttcaatttga taagcattag cctttatacc aagaaattca
     1741 caaattaagt gcgttttctc ttgtatttct gatttttcct cctcaagcaa tatttgaatt
     1801 gttttatata gaatacctct ctttaatcct tgtatttgag gacgtatgtt aagaataacg
     1861 tcatcatata agctgctgag attatcatct tccactatac tttaaagctc cttttttaaa
     1921 atttttctaa atttttaaag tcttttataa tactttgagc tttttgttgc ataggctgcc
     1981 aaagtttcct attattctca taatctaaag taatatcttg cttggctcta tcaagtctag
     2041 cttgataacg gtcaataata ttattttgaa ttttatctac atttcttttt aaagaatcaa
     2101 tttgttctag taaccaacag acaatttgat atacaatctc tctctgttct tcatcagctt
     2161 gatctatcca accttcgagt aaatttctta cactaggaat tacagcatta tcgctagagc
     2221 gttgtacata atcgatatat tttttctgta gtattacacc tttacctaca aagtcgccta
     2281 caaatccttg aatagttcca gcaagccatt cccaaccgga ctttcctata gtatttcttt
     2341 gatgtgcttc ttgtaacgta ataattgttt ctttttcttc ttgccaactt ccttgggtaa
     2401 ttgcaaatcc cgctttaaat ttaaaggtta tggtaggatg tttttcaact ttaacaattt
     2461 gagattcagg aaatgtaatt gctatatgag gcgcaatctt atttgcttct ttttcaagat
     2521 atgataaatg acaatgaaaa agttctacta ctgcttgata cattctattt aactcttgat
     2581 taaaaatttg cttcaataca tcctccataa caatatttaa atgaatagat aattcattta
     2641 actcttcatt tatttgcttg agtttatttt tttctagttc tgtctttgct tccattattt
     2701 caccttcttt agcaatagaa gctgtatacc ctaaattaat tagtcggttt aagtttttat
     2761 ttaataaatt tacatttaat atatttgctt tgtttaaata tgtgatatct aagtctactt
     2821 ttccagtttc tagagatttt gctacggctt ctaaaatttg atgaagccct ttacctaatt
     2881 ctctgcgcca tccataaagt ggatataatt tttctcccaa ttcagtgtaa ggcttaatat
     2941 tttggatttc cttcagtttt ttttccaaat aaaatactgg atcgtcttct gatggatttg
     3001 caagcacctg tttaactttg gcatttattt cttcaaacgg cttgctcaga ttttgattac
     3061 ttatttgcag aaaagtctca agtgtagatc taatccaaga tattttttca cattcttgtt
     3121 gatagcgttc ttctgaactg ttaaggaaag ctgttgttgt ctgcaaagcc cactctgtaa
     3181 cagcattacc agcagcaata ttaaaacgtt ctatagcttg gggaataact aaccggggaa
     3241 aatgttggct aatatgcgct ctcaagcctt gttgaaactc ttctgcataa gatttttgcc
     3301 ataacgtatc agcaacccta tttcgatcat gcctagacca tttttcaact ttacgcggta
     3361 aatcctctaa tatgttttca tcaatcaatc cattaaagtg gttatctgct ttcttacaag
     3421 cttctgtact gtatatttca tcattatttt ttatttgcag tgctaataaa gccgcccacg
     3481 tactcagttt tataacttgc aatttttcaa tatcttctgt atattctttt agatgttcgg
     3541 taagttcgta cttgatactg cgtatcgcat tttcaacaaa gcgattttct gtttcagggt
     3601 aatttctatc tgctcggaaa acatcgatac gattgagaat aaataacata cgtgcaggag
     3661 aaccgcctaa atcttttacc tgctctacca cttcttgcag caagcttcta actttctgtt
     3721 gatcggtttc tgcactgttg taggttacca aacacaatgc ttcacgacac tgtttaatca
     3781 catttgcgtt accttcatca cctacataag ctaaacctgg taaatccata attcttacct
     3841 tgacacctct gggtaattcc agttttgatt ctttaatgag tctgaaagga taagatatgg
     3901 ttgattgcgg gcaagctaaa ttaggttgtt tctctctgtt atcgatgtaa cttatcatta
     3961 catcatacaa gcgttgataa attcgctcat cacttatacc tgtccattct ccacactccc
     4021 ataatgctcc gggagtttca tggataatta aagacttttt ctcgctatat tctatagtta
     4081 ctgcccctgc actcatttcg ctcacggcga caggaacaat ttctgctcca cataataaat
     4141 ttactaaagt gcttttaccg ctactagttg ttcccgttgt tgcgagggta agagtaggat
     4201 tttgaagctc atttactaaa ttttcaatag ctttctctaa tttttcagta agttcttgca
     4261 cttctggatg atatgtatca ggtaaatgtt cagatatttc tgtagagaag ttatgccaat
     4321 atttagagag aagttttgca ttttgttcta catcttcaaa gactttatat aatttagtgt
     4381 tcattattta agcctattta aaattttatt ttttacttgc actcaaatat agattttatt
     4441 gaaaattaag agaagggcaa aagagaaaaa atagttcgtg ttgaaatttt acctaattag
     4501 gtttaattgt gttcaatgaa tgagtcacgt atctcttctt ttcttctata aaatggctaa
     4561 ttctattagg gtgaacacta ccgagtttta gatactggtg gacatatgag tagtgctgct
     4621 gccgtgcctt gagggaatct tatggtaaaa agtagtgaat tagtaactag atttgatact
     4681 tttgactttt tctttataat ctggaaataa ctgaaatgct tatgtaatac tactgattta
     4741 gattcagatt tttaatacag tcaaaaaacg aatagatcaa aaatcgtaag aattaagact
     4801 agcaaagcat ttcagtaggg gaaaaaaatg atgttatcta atatatattg gcaacttttc
     4861 actttacctt gaagtgataa ctccaatatt tttcatcaag aaaaattgat ataataaata
     4921 gaggcgaggt tttttgtatg tacgttacca taccaactcc caatcgcctc atgatgggtg
     4981 ttttgatttt ttagggtttc ctgtttgact tttaaacaga taagttaaaa taatacaggt
     5041 aaaataaaaa atgaccctat aagtgagggc attctataaa ttaagttagt aactagcagt
     5101 cattcagact agccagtttt tagccagctt gttggcgttt catctcttgt atcaatactt
     5161 gacagcgctt catagcttct cttgcctgtt gtcggtactg tttggcttgt tgcggatctg
     5221 attcatacac ttcagaacct ttacgccgga gttcaacagc ttgcttactg agttctttag
     5281 cgcgagtctt taaatcttca attgttttca tcattcctcc agttctgaaa tcacaaattc
     5341 tatattttca gcttcttcat aaagtttatc tgctctactc tctagtaagc tagcgtcctc
     5401 atagtgattg ttgtttaggg cattttgaga tgctatatac aattcatcaa taatgcctta
     5461 taactggata taagcactta ccaaagcgtt tctggtttca ggtctcatat ttacaattca
     5521 atcccaccat caaaatcatc tggttcctct acatcaatca cagtaacttc aggatgtaat
     5581 ttttgctcat tctggctcac ttggcttact ggctctacta tagtcactgg ttgtttgcca
     5641 tctaaatacc ttgtgtaaaa gttgatagca tcttctataa acttcgttac cgggatatct
     5701 aacgcttgtg accattcctc aactttggat tgctgatact ttttaatcct aattttgtct
     5761 atagccatta cataacctca ctgaccaatc ccttaaggtt gtcaaaagca ccgttatctg
     5821 acattagaaa accttttttc ttaagtgctg cactcagtaa ggggagttta gatccaccac
     5881 caattatcag aattttgtca ccagcaagct tgtattgctc taactgcttt gtgacctcat
     5941 aaaaatttaa tatgaagctg catagaaaag ggcttctaaa ataaagttgt aagaagagac
     6001 ggacataact tgttcaagtg taagttggtc aagtacttct tggatgcgat tgcgtaaagc
     6061 ctgcaaggaa caaaaaagtt cattttttaa cggttgtttt agcaacgccc aaagcctctc
     6121 aataggatta agttcaggag aatgaggtgg ttggagtcaa ggaattatgt tttcaggcca
     6181 actaatcgtc aaattcatgt gagatggggc ttggtcaatc tgtaaaacgg cgtagtcttc
     6241 tcctaattcc tgcgatcacc aattgaaaaa ctcttgaaag cgttctccgt ttagttttgg
     6301 gtattcgtgg aagaaatgat ctcctgttct gggttcaata gcaccatata tccaaaaatt
     6361 ttctctgata aatatttagc tctatacaat atgtcattcc gataaatttt accctaattt
     6421 ttcgctcaca aataatttaa ctggttacta gcaaataact agtaaccagc aatcaaccag
     6481 caccgaaaaa tgacgagtta cgcgtacagt acttgcacca tgatttattt atgaaaaaag
     6541 aaattgatta atttttcaaa tcccctactt ttaagtataa ggattcaccg atcgctgctt
     6601 actccgaaat aactgcaagc tttcttggtg gtttctgcat cttcaagctg aggcttttta
     6661 aagtcattct cggttcgctc ttgttcaaaa taaccgcctc ataaggtaca actccggcta
     6721 attcactatc aatacagcga gctgctaccc tggataaatc caaacttcta gggggaatat
     6781 atggaccccg gtcgttaact ctcacaatga ctgtcttgcc atttttcaaa ttcgttacct
     6841 gtaagtaggt gttgaatggc aaggatttgt gagcaaccgt caattcgttt tgattaaatg
     6901 tctctccatt tgctgtcatg cgaccgtgaa agtaaggacc gtaccaagaa gctaaacctg
     6961 ccattttttt cttggaagaa gtcaatccat acatttcctt ctgtccttca acaagtgata
     7021 gcttgggcac ttgcaatgct tgacgcaaat tatttaccca ttcgatcgct aataaatcgg
     7081 cactccgatg ggtttttcga gtgacttctt tcccaattcc aaacaaaaag cgattgcctg
     7141 acattaacgc tggtattcca tcaacaagcg caggacgcaa ccgagaagca tcaaagctag
     7201 atgatttcac aagtcgtgtt aggcgttgct gcattaaact ggcttgttgt cggtctggta
     7261 aatttgcaac tatacggtta tttagccaca cttcgtaatt gctcgtccct cgatgaacaa
     7321 ctacagcagg cgcagaagta gaatcaaatc ccagttctat aggattgtcc aagcgaaaga
     7381 aattttggag cgatcgcagt atctgatttg ggagaaaatc tcgattatcg aaccctgtct
     7441 ctatcaaact tggaacgggt agaagacttg caactttaac agcaggctgc ttggctagat
     7501 tctcttgttg aagaccgcaa aactgatttt tgctattttt atctctctta atgagcggag
     7561 cgagtggttg agtgccattt ggttttgatt ccttatcacc ccaatccaat tttaaaaacc
     7621 ttcttgacag cattgttgtg cctacaacat tcatttgctg cttatcgggg attaaaaatg
     7681 ggagaggttt gttaaccagt ttccctaagt tggatgacac ttttgccgga agaatatttg
     7741 aagccaaact tggtggcaag ttttggttca acgacaaaaa tgaaccaatc caggatgtta
     7801 cccaaagtag tccaaaaaat atcatggttc agtcagtttt caggtaagta caccttttga
     7861 cagtgctaac cttgttcctt gataatgaca atttcccaat cactaaacca gcggtctact
     7921 cttctaaaga gtaagaattt accctggttg tgattaagat actgagcgat cccagcaggt
     7981 atcatattat cctgttgttg ctaaacaagc aaataaaagt tttagatatc ttttttgctt
     8041 attactataa tttcaattta aattttttat aactggctgg cgctcaaata cagcaaagcg
     8101 tttagaaatc gccttttgac atcatttttt ggaattggga attttggaaa aagtatcaat
     8161 taatataggc atcaggagtt aagggttagg atctggggaa aaaatttttc atgtttggag
     8221 atcggctttt cccttgattg gctgactgac aaaaagaacg ccacctctgt tactaagcac
     8281 ttatagaaac ggggttaaaa agcccccctg tctccatgag agagggtgag gcttgtgaaa
     8341 aggagtcggg gaataatcaa agaagtatgc agccgggaaa cgagaataga agaatgctga
     8401 atgccccatg catcatgcct tttgctgcat aagtatgccc attacccaag aggagggatc
     8461 aaagaaaatt cacaatctct gggagattgg aaaaaaaaca ctgccaaatg taacggattg
     8521 caaagtataa taaaagcgat aaaacgatta agaattattc aatatcacaa aggttaaatg
     8581 cgagtagcga tcgccggagc gggtttagca ggcttatcct gtgccaaata tctcaccgat
     8641 gcaggttaca ctccaatcgt cttagaaagc cgagacgtgt tggggggact ggtagcagct
     8701 tggaaagaca aagacggcga ctggtatgaa accgggctgc acatcttctt tggagcatat
     8761 ccaaatatgc tgcagttgct gaaagagttg ggtattgaag atcgactgca gtggaaagaa
     8821 cacacgttga tcttcaatca gcctgataac ccaggtacct acagtcgctt tgattttcct
     8881 gatataccag ccccttggaa cggcataatc gctattttac gaaataacga tatgctcacc
     8941 tggccggaaa aaattcgctt tggcatcggt ttgataccgg cgatgattca ggggcaaaag
     9001 tacgtagagg ctatggatcg atactcttgg agagagtgga tgaaaaagca aaatattcct
     9061 ccaagggtag aaaaagaagt ttttatcgcc atgtccaagg cgttaaattt tatcaatcca
     9121 gaagaaattt cagcaacaat tcttttaacg gctctcaatc gatttcttca agaaaggtat
     9181 ggctcaaaaa tggcttttct tgatggttcg ccaacagaac ggatgtgcga gccgatggta
     9241 gaatatatca cttcacgagg tggagaagtt cggttgaatg caccgttgaa agaaattttg
     9301 ctgaacgaag atggcactgt caaaggatat gtcatacgcg ggttgcatgg agcaagcgat
     9361 gaagtggtaa cagccgatat gtacgtctcg gcaatgccag tggatgtcat gaaggtgatg
     9421 atgccagaac cttggaagca aatagaattt ttccaaaagc tagaaggttt ggaaggcgta
     9481 ccggtgataa acttacagct atggtttgac cgtaaactaa cagatattga ccagctgctg
     9541 ttttcgcgat cgcccttgct tagcgtttat gctgacatga gcaacacttg tcgcgggtat
     9601 gaaaaccccg ataaatcaat gctggagtta gttctagcac cagcagccga ttggattgct
     9661 aaatctgatg aagaaatact acaggcaacc cttgccgaat tagaaaaact ctttcccgac
     9721 cacttcattg gagacaatcc gacaaagttg ctaaaatacc atgtcgtaaa aacgccgcga
     9781 tcggtttaca aagcaacgcc cggtcgtcag cagcaccgtc cagaacaagt gactccagtt
     9841 tccaacttct atctagcagg tagttacacg atgcaacgtt acttggggag tatggaaggt
     9901 gccgtacttt ctggtaagct gacagcgcag gcgattgctg aagcgcatcc agtagcaaaa
     9961 tcgtcaagcc tgcaaatgca aacccttcag cctgcaacga atgctgcaac tgcctgattc
    10021 tcccccacgc ctgaaaacgt tggtctcggt agacgagtcc tacgaacttt gtcgccaact
    10081 cacagaaaag tacgccaaaa ctttttacct ggctactttg ctaatgagta aggtcaagcg
    10141 caagcatatt tgggcaatct atgcttggtg tcgtcgtaca gatgaactag tggatggtcc
    10201 cgttgctgct atcaccacac cggaaacttt ggatcggtgg gagcagcaac tgaaatctat
    10261 tttcgcagga cagccaacgg ataatttcga tgtagctctt gtggataccc ttcagtcttg
    10321 cccgatggac atccaaccct atcgggacat gattgaaggt cagcgcatgg atctataccg
    10381 aagtcgttac caaacctttg aggagttgta tctctactgt taccgcgtcg ctggtactgt
    10441 aggcttgatg tcaacagcag ttatgggcgt ggatgcatcc aaccaatcag ccccttggta
    10501 caaaagcaag ccaccctata atcctacgga agaagcaatt tctttgggaa ttgccagtca
    10561 aatgaccaat atcctgcgcg atgtaggaga agacgcacgt cgggggagaa tttatattcc
    10621 tctagaagac ttagcgaagt tcaattacac cgagcaagat ttgatccaag gtgtaattga
    10681 tgagcgatgg cgagcattga tgcgcttcca aatcaccagg acgcgccaat tctacgcaac
    10741 agcagaaaga ggaatcagct atctatctgc tgatgcgcgg ttacccgtat gggcggctct
    10801 catccattac agcgggattc tcaaggttat tgaacgcagc gactatgacg tgttcaatca
    10861 gcgtgcttac gtgccgaaat tacaaaagct aagtacttta ccagtggcat ggttgcgagc
    10921 acaagtgtta tgaggttagt cctcggtcat cggtcatttg tcatacaaag gacaagagat
    10981 cgatgacaaa tgacaattaa ctattgacaa gccaaatttt gttctggtaa cattagtatt
    11041 cgtgaccctg gagaggtggc tgagtggtcg aaagcggcag attgctaatc tgttgtacgg
    11101 ttcgtaaggc cgtaccgagg gttcgaatcc ctccctctcc gtttttcgca aaagaaaaat
    11161 aaattaagaa aagatacatc ctcctattgg gggatattgc tgttattatt tatcttctgg
    11221 agccaataga aaaactgacc tgacttcaaa acaggaattg gagactgggg aacaatcacc
    11281 gatcgccaat tgctttttca taagtcccgg tatacacagt taaaacgact tctggaaatt
    11341 tagtcaaatt ttaattttaa tattcaggct cctattaaag aagaggagtg aaatttactg
    11401 catgaaaaga acaagcacag ccttagcact ggctttatta acaacaggcg tgggtttcct
    11461 gacagccgct tgtgataccc aagcccctca aactccaaca actagtagtg gtaacacaac
    11521 cccaggaagc tcaaatacaa ctggtagtgg tagtgggcta aaaataggtt ccttgctccc
    11581 agcaactgga gatctatcct ctatcgggca acaaatgata ccagcagttc cctttttagt
    11641 tgagacagtc aatgcttgtg gcggtgtcaa cggtcaaccc gtgacactca ttcaggtaga
    11701 cgaccaaacc gatcctaaag cgggtgcgat cggtatgaca aaacttgcaa ctgtagataa
    11761 ggtagcgggt gtggtcggtt cctttgccag cagcgtttct actgctgctg tctcaattgc
    11821 tactcagaac aaagtcatgc tcatttctcc cggtagtaca agccccgtat ttaccgaaca
    11881 agcaaaaaaa ggagaattta aaggcttttg ggcgcgtact gttccacctg atagctatca
    11941 aggaccagcc ctagcaacac tggcaaataa aagaggttac aagcgagttt ccaccctcgt
    12001 aattaataac gattacggcg ttggttttga acaagcattt gtacgagctt ttgagaaatt
    12061 ggggggaact gttgttaaca aaaacaaccc agttcgttac gaccccaaat caaccacgtt
    12121 tgagagtgaa gccgcagcgg cttttggggg caaaccggat gccgttctgg gagtttttta
    12181 tgtagaaaca ggtagcttgc ttttaaaatc agcataccag caaggattgc tccagggggt
    12241 tcaggtgatg ctgactgatg gtatgaagtc agatgagttt ccccaacaag ttggcaaaac
    12301 aaacgatgga aaatatattg tcactggcgt aattggtaca gtaccgggtt ctaacggaaa
    12361 agcattagat gctcttacca aactttggca atcgaaaaaa ggtggttcac caggagaatt
    12421 cgctcctcaa tcatgggatg caactgcttt actcgtacta gccgcacaag ctgctaagga
    12481 gaacacaggt aaaggtatag cgaacaaaat ccgtgaggta tcgaatgctc cgggagtgga
    12541 agtcacagat gtttgtgagg gattgaagct actgaaagaa gggaaagata ttaattacca
    12601 aggagcaagt ggcaacgtag atgttgacgc aaacggtgat gtcattggta tttataatgt
    12661 ctggagtgta gaagctgatg gcaaactcaa aaccattgac aaagtaagtc cgcagtaaag
    12721 tagattacca gtcaatctga ctttgaatta aatgcacgat taaggtgggc aatgcccacc
    12781 tgagtgagtc tttatttaac gaccaaagag actgccaaag ttgtaaccaa ttccaatcgc
    12841 caaaccaaca tctgtattat caaaaaatgc tgcatttacc gcagctgttg ccgtaaactg
    12901 agatgatatt ggtacgtcaa taccaccagt tagcaagaaa gcaacatcag catcgtcgct
    12961 cgtttcaata gcgacaccag caccaagata aggagcaata ggcaatggtt cggagaaagg
    13021 atctatcgac ctgaatgaaa agtcataagt taccggaatg agaatagctg tatcgtctcc
    13081 aatcacaact gagggacgcg cagataaaac acgtgtcagc ccgattttgc tgagaaccat
    13141 aaagttccca tcgcccaaag cagagtcgcc acccaagccg atgtttcctc ctatcccgat
    13201 atagctcgag ccaccgcgag ttcttcgccc tggatcgaca gtcgtaatat cggattgtgc
    13261 tacttgagaa gtagatggct taagctgcgt ttctgtattt tggggagtga caagcactgc
    13321 tgatgatgtg aacgtcgttc ccggtacggg agtcactaca ttgttagaag tttccggttg
    13381 tgtgtgattt tgtactggct gcacccgatt tagctcacca gcagatgcca cagtattttc
    13441 gggaacagaa gattcctgca cagatggagt aaaaacattt ggatagaagt tttctacctc
    13501 aacgggtgtt gtttggggag atacttcagt tccagaagat aatgtcaact gctcgccgtt
    13561 tgcagtatct gctacttgag caacagcagg cacgctgaca ccaagaagtg ctacagccga
    13621 tagacttagc aagcaaaaag catttttacg gaaaaaaata gtgttcacaa tcactcctca
    13681 aaaatattgc ctgaaaaata attaacttgt cagattttca gccaactttt agcaatatcc
    13741 accatttaac actaaaaaaa tcattccatc atcctctatt ggatatgccc gtgcagaaat
    13801 tttcaattat ttcaagacct tctgaatgaa accgcctcta catggcatat agtgaggact
    13861 ttttatctta ttcaagcggt cttgattctg aacgttctta cctactcatc aatttgccaa
    13921 gaatctttgg ttacattttc atctacaatt ctcctgggtt ttacaatcac aatgattctt
    13981 cccaaaagag ggacttctgg ggatgtttca aaccactgaa agtctaattc tccagagtta
    14041 tctactacaa aataactgtt tgagtcccat tctcgttgag cgcggtctac aactaccaac
    14101 actggttctg atggattttg gatctggttg ggaaatttac cgcttttaca caatatcgcc
    14161 acggggtctt ctgcacttag caagacttgc cagccgggta aaggaaccca agcttgctct
    14221 ccggcaaatt taaccatgcg aaatggttct atctcctcaa tgaggggtac tgcttgcaaa
    14281 tcttcttgtg tcagtggtag ttcaccaact actggtatag cacgaggtaa gtccgcttct
    14341 gattccaagc gataaaaagg cagagaagga gcgggacgac tgggaacaac ggtaaaatcg
    14401 gtaagtaatt gttcgatttg tttccgggcg gtttgcgagt aggcaaagcg caaacctttg
    14461 gcaatcaagc gagaacgttc ttgtaaatct gtgttttgac gggctaactt ccaagcttga
    14521 taggcaacag catcgcctgg atgattctca aatccctctg gtagggtacg gaagcgagaa
    14581 aactctttta ttgccttggc gatttctttt gcaccatcaa catcaatttt attttggaag
    14641 gccagttcgg ctgctgctgt cctttcttct tgggttagca ggcgaaattc atacaaaata
    14701 tcgctacctc tggtggagta atgcgatcgc acttctgctg gtgcatttac tttttctata
    14761 gaattgtaaa cttgtgcgcc aacagtgact tgattttgtt gtacgggctc aaatccagtt
    14821 gcttcaaaaa tttcttgtgg attataacct agtttttgca gttgggcgat cgcaattccc
    14881 cattccaccc agttaccttg tttttgtctg agttttctta gcaactctag ggctacatcg
    14941 ttgttatttg gctcttgaac attaggtggt aagtcagtca taagtgtttc agcaagcttt
    15001 tagaggagaa gactatatta aaaatttaca agaagaaagc cagaaggtag aaaggaagat
    15061 gttaccgagc attaataaat attaataata cgtaaattta cgcatgcaaa aagttgaatt
    15121 tgtctgcgat ttttcttgta gtttttgtca aaagtgagta taaccagttc aggtgcgatg
    15181 aaatattact tatgcctaag attgtgttaa gttttaagcc tgctgagtac agaatataac
    15241 aaaaaatcaa gattaaaagg aatctgttta tgaataatcc ccttcccgaa ttagataaaa
    15301 tccgccgtca actcgtgaat gtagaaagcc gtagaaaggc aaaaatgcta gtggttgacg
    15361 acgagccaga taatcttgat ttgctgtatc ggactttccg ccgggacttt caagttctaa
    15421 aagcagacag tggagtgaat gcgctgcaag tgttggcatc agaaggagaa gtcgcagtta
    15481 ttatctccga ccagaggatg ccagaaatga aaggaacaga gtttctcagt aagaccgttc
    15541 ctcaatttcc cgacacggtt agaattattc ttaccggctt tactgatatt gaagatttag
    15601 tagaagcaat caacgccgga caagtctaca agtacattac caagccttgg gaccccgttg
    15661 aactcaaggc agtagtacag cgagcagtag aaacctatga attgctaaag caacggactg
    15721 aagaattgag acgcgccaat gctcaaatgg ggttactagc tgtcctcgta cacgtgactc
    15781 aacaagcttc tagcctggaa gcagcactcg atcctatcgc caaagcattc ggcgatagtt
    15841 tttctgcaga tgggtgtatt ttgcaactcg tagagggtaa ggctttgatt gcaaagcaag
    15901 gcacttacag caatggagga agtttagaaa attggctcga tcgcgacccc ctgacaacag
    15961 aagccattgc caaccagcaa ctacaagttt cagtcaatat acccaacgat caaaagctag
    16021 ctggtgttgc tcactatcag tcgaacagcg tccaagccca cttgattatc cccatcactt
    16081 ttcgagaaga agttttggcg gtgctgtccc tacaatggaa acaaccttgc actttacgtg
    16141 aagatgaact gaaactgatt catctatcag cacaactagt tgcgatggcg ctgattacca
    16201 ctcgtcacta tcaaccgact tagtaaatca gcaaaagtct taggaatttc tagggggaaa
    16261 attattccat attgtgggac ggagagggac gtccacacta caacaaatgg tggtcgttac
    16321 tgaataaaac ccttctctca aaggagttgg gagccctttc cttttggaag agggctccca
    16381 atgcagtttt cacgattaca gtgcgcccgc ctaacgctac acaatggtac ggatagttcg
    16441 atgagttctg ctttatatta accagacata ctaagacatc cttcaacaat tcttgcttcc
    16501 actagcgcag ttggctgctt atctcatacg agaagagata cagcagattt caacttggtg
    16561 aggtacaaaa attacccccc tctgtccccc aaagcatcgg ggggatgaaa ggggggtgta
    16621 cctcaccgtt actagcccca atgcgttgca tattactccc tttccgccat aagactaccg
    16681 atcttcttct cctctttcct ctgtgtcctc tgcgcctctg cggttcattt aattaagaaa
    16741 tcttcgagcg ggaagggagt aagtacaaat ccaggtaaaa cttttccgcc tgaaagagtt
    16801 tgaggtaatt ttcaattacc tttctggaat cccatactac tataatgtat ctagaataaa
    16861 ccctcaatac tcctcagata gttgaaatga agtagtagca aaaaacggtt cccaaaaaca
    16921 atagggactg acaacagaat tttttggctt taagcaaagt ctcacatctt atagaacgag
    16981 cgttaccttc ggattgtccg gcgttggctg cggaggaaac cctgctctag cattggtctc
    17041 accgcctgct ttctcctgac tcagcgatcg tcatagtatg gggacaaata tttacgttat
    17101 tggatagaag catgaattat cctcatccct aactcttctt cccgtgggag aaggaagaag
    17161 ggaatgggtg gggaaactat gcactacata gttttattgg ggtttggaaa gaatgcagaa
    17221 aaaatcaata ttgttggctg aaaatttggg ctatgaactt agcgcaacta gggtcttatt
    17281 taaaggcgtt catctcagca ttgcagagaa agatcgcatt gctttagttg gttctaatgg
    17341 agtgggaaaa tcaactctct taaaaatctt agccgctcaa cttaatccca caacgggttc
    17401 tattacgcgt caaggcacaa tatactactt accgcaaatc agcactatta aacaggagag
    17461 taaagcagaa acagttcttg attttttaag ttctatttct gaggaatggt gggatattga
    17521 agccattttg gaaacacaat tcaataccaa tctcgattta tccttaccgc ttttcaatct
    17581 tagtggtggt gaactcacaa agttattcct agctattggt ttagcacaac aaccaaagtt
    17641 gttactgtta gacgaaccaa ctaaccatat ggatttgatg gcgttagaaa gtttaaaagg
    17701 ctttctcaat aactttgaag gagcatttgt ccttgtttcg cacaaaccat ttttcttaga
    17761 ccaagtaaca gaaataactt gggaactcac accagaggga atcaaagttt atggaggtca
    17821 tttttcttta taccgagaac aaaaagaaac agagttagaa gcagcattgc gatcgcatga
    17881 agttgcgaga aaagaactca aacgtgctaa agcctcagca ttacaagaac agcaaagagc
    17941 agcccaatcc cgcaaaagag gtgagcagct agcaggtagc attcctaaaa ttgtagctgg
    18001 aatgatgaaa cgaaaagcag aggtaacagc aggaattgca aaacaaaaac atgaagccat
    18061 tgttgagaag gcaacacaga aatttacaga gacaaaagtc agaacagcaa aggctacaag
    18121 tattcaattg gaagaaagaa gtcaaaaacg gagaaatctt attgatattc agggtgcgaa
    18181 tctttgggta ggtgaaagct tgctaattaa aaacattcag cttcatcttt cttcaggcga
    18241 tcgcataact gtagctggtg ctaatggttc tggcaaatca agtctggcaa aagctatttt
    18301 gcctaaattg gcaacagatg atgcacggta tttaaccaat aagttatcga tagagcttaa
    18361 agatagctca accgctatac tggcttcaag atcgacaaca aaagctgtat atctcgacca
    18421 aacttacgaa atcgtcaatc gtactcagac aattctcgaa aatatgcaag ctgctaaccc
    18481 caatcttagc tatcagcttt tgcgacagca gttgggacac ttcctattta aatatgatga
    18541 tgtcaacaaa ccagcatcag ttttaagtgg gggtgaatta gcaaggttag cgatcgcgat
    18601 tatcagtatt tccgaaatcg atctgctgat tcttgatgaa ccaacaaaca atttggatat
    18661 cgaaaccgtc aatcaaatgg tagaaagtct taatgaatat caaggtgcgc tttggatcat
    18721 ttctcacgat ttggatttct taagccgcat tgatattcac caagcttata agttgagcca
    18781 gcaaaccctg caaatgacca catacttacc cagcaaaccc gaacaatatt atcaagagtt
    18841 acttactagc tagaagtgtt gaatgagtct cttttatttt tgaactgaga tagggcgggt
    18901 aatgcccacc ctagaatact tagtacttac aattttttat aaattatcta tgcttgttat
    18961 aaaggacgac gcaatagata attctttaac ctgtagagct tgctctagat gtatttctac
    19021 cagcaaaatt tttagatatg taaagatcta ccgtttgaca catctccaaa atccaaagaa
    19081 tgtaaatttt tgtacattac gagatgtata ttttgaaact taaaatgcta ggattttgtt
    19141 ttaatgtact ttagtagtgt taatttgatt gtcattttta taaattaaca ttttaaaaat
    19201 taacgtgagt tcgacagacc tcacactcac ttcctctcat caaacggcag aggaaaacca
    19261 atcttatcat cagggtttga aagccctctc tttgcagggg aggggtttgg ggtgctgtct
    19321 gttttgactt cagtaaactc gcgttaataa ttaggaggtg atgaaagttg aaaaatatac
    19381 aataccatac aatcaccttg tggaaaaatt atttaaatca actctggttt cgtgtagtta
    19441 ttgcttttac tattgcttat attattatgg taatagcaag ttgtatagat aaatggtcta
    19501 acaatcaaga attttgtcgg attaaagaac ctttacaaaa ttgttatttc agacaagtaa
    19561 tttctatatt tgcaccaagc aatattgaag gttttagtat attaaccgta gccattttat
    19621 atatattaga aagccaagaa cgtcgcgaaa acagaatata tgaggcatgg caagttgttg
    19681 ataatgcatc agcggcaaaa gtttctacta gctacgctag aattaaagca ctagaagatt
    19741 tgaataagta ccgagtttct ctgaaaggaa ttgacgttcc tggtgctaat ttaagtgaaa
    19801 tcaatcttag aaacgccgat cttaaagaag ttgattttaa tgattgcatc tttagtaatg
    19861 ccaaccttag caatgccgat ttaaatggtg ctaacctcag tgatgccaat ctcatctccg
    19921 ccaatctcag caatgccaat ctcttttttg ccaccctaaa tgaggctaat ttaagcggtg
    19981 ccaatcttaa tggtgctaca cttttctttg ccgatctcaa ctgtgccgat ctctgtaatg
    20041 ccaatctgat tggtgctaat cttaacagtt ctattcttaa taatgctatc ctgttttcag
    20101 cagacctaag caatgcccaa ctttggagtg ccaatctgag caataccgat ttgagtgata
    20161 ccaacctcag cggtgctaat cttaaagaag ctaacttgag tagtgctaat ctcagtggtg
    20221 ctaatctcaa aggtgctaac ctcagcagtg ctaatctcca agaagcgaat ttaagcggtg
    20281 ctaacctcag tggtgctaat ctcaaaggtg ctaacctgag tgatgctgat ttccgatctg
    20341 ttaaaagtct tgaaatagaa caaatcaagt ccgctaaaaa ttgggaaaaa gcactgtttg
    20401 atgaattatg aattataaat tctgaattat gaattgaagg tttgagcatt cataattcat
    20461 cattcatcct tcataattta tctcagtccc agccaatctt ttatctcttg aattaaccaa
    20521 agacattctg gttcactcgt tttaaaatca aaatctccaa atttgtattt atcttcaccc
    20581 gctgcaacga tcagtttcat tctttctgaa gaatcttctc ctcctttgga ttgataaatg
    20641 taaacataaa cattgtgtat gtcttgcgtg tttccatcaa gatatcggta acgcttaccc
    20701 aaaatactcc atgtaattgt aaaagtatct ctttgaaagt caacgttggt ttcagtcagc
    20761 ggcgcaatca aggaactgag tgaaagaatc gaaccagcta acaaaattaa gggtcctaaa
    20821 cctgttccca tactaaataa tccagcaaat agactagatg cagttaatcc aattattaga
    20881 ctgcaaaaat ctaaagtttt taggcctctt ttgggaagtt tgatgttcag ttt
//
