LOCUS       NZ_JHEG04000001        23288 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Tolypothrix bouteillei VB521301 NODE_1_length_9494340_cov_10.278967,
            whole genome shotgun sequence.
ACCESSION   NZ_JHEG04000001
VERSION     NZ_JHEG04000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Tolypothrix bouteillei VB521301
  ORGANISM  Tolypothrix bouteillei VB521301
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Tolypothrichaceae; Tolypothrix.
REFERENCE   1  (bases 1 to 9494340)
  AUTHORS   Chandrababunaidu,M.M., Singh,D., Sen,D., Bhan,S., Das,S., Gupta,A.,
            Adhikary,S.P. and Tripathy,S.
  TITLE     Draft Genome Sequence of Tolypothrix boutellei Strain VB521301
  JOURNAL   Genome Announc 3 (1), e00001-15 (2015)
   PUBMED   25700407
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9494340)
  AUTHORS   Sarangi,A.N., Mukherjee,M., Ghosh,S., Singh,D., Das,A., Kant,S.,
            Prusty,A. and Tripathy,S.
  TITLE     Improved Assembly of Tolypothrix boutellei genome
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9494340)
  AUTHORS   Sarangi,A.N., Mukherjee,M., Ghosh,S., Singh,D., Das,A., Kant,S.,
            Prusty,A. and Tripathy,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-NOV-2019) Computational Genomics Lab, Indian Institute
            Of Chemical Biology, 4, Raja, S. C. Mullick Road, Jadavpur, Kolkata,
            West Bengal 700032, India
REFERENCE   4  (bases 1 to 9494340)
  AUTHORS   Tripathy,S., Sanghi,N., Chandrababunaidu,M., Singh,D., Panda,A.,
            Gupta,A., Das,S. and Adhikary,S.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAR-2014) Computational Genomics Lab, Indian Institute
            Of Chemical Biology, 4, Raja, S.C. Mullick Road, Jadavpur, Kolkata,
            West Bengal 700032, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: NOV-2019
            Assembly Method                   :: SPAdes v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000760695.4-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 03:45:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,181
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,922
            CDSs (with protein)               :: 7,922
            Genes (RNA)                       :: 97
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 164
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 164
            Pseudo Genes (frameshifted)       :: 41 of 164
            Pseudo Genes (incomplete)         :: 132 of 164
            Pseudo Genes (internal stop)      :: 36 of 164
            Pseudo Genes (multiple problems)  :: 40 of 164
            CRISPR Arrays                     :: 25
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:00:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3156582
            Orig. end                         :: 3179870
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JHEG04000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23288
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="15"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23288
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23288
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13288](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13288
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    518..532
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.9"
                     /tool="antismash"
     gene            600..1466
                     /locus_tag="HC643_RS12550"
                     /old_locus_tag="DA73_0400012550"
     CDS             600..1466
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="HC643_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012550"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_050045727.1"
                     /transl_table=11
                     /translation="MFVRDINKCQQPFLTLQRAQEAPEQKVRKLLAKLSYMNEQLCHEK
                     ALRLRAEAELEKSLALTKKEPLVSMICHEFRSSLNVISFSTSLLKRHHHNWSEEKTLQY
                     FQRLQTTVEQLGQLMDELLTIERAEAGKLEFEPTSVNLISFCHDILTQMNLSENSQNAI
                     NFVIQGDSKAVCIDKKLLQPVLTNLLSNAIKYSPNGSTVDMILSYLDEEVIFTIKDRGI
                     GIPKADRQRLFEPFHRGGNVGDKPGTGLGLAIVKKFVDIHGGEIIIESEVGVGTTFTIA
                     LPCQMCH"
     gene            1583..2374
                     /locus_tag="HC643_RS12555"
                     /old_locus_tag="DA73_0400012555"
     CDS             1583..2374
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017746863.1"
                     /locus_tag="HC643_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012555"
                     /product="response regulator"
                     /protein_id="WP_038078790.1"
                     /transl_table=11
                     /translation="MTKVLVIEDEVESRNIFLECLEAEGFDTISAENGLIGVQKAQENL
                     PDLIICDVSMPELDGYGVLTSLRQNTGTARIPFIFLSAKSTKAEVRQGMTLGADDYLTK
                     PTTAEELLEAIATRLKKQATIKEWYETQSPQVTPPPANTAPSADSQSSSPASPQLKEVF
                     DFIEANYHQAISLSDVAQAVGYSPAYLTDLMRRQTGKTVHQWIVEHRMTKACSLLLETK
                     QSVEQIAEAVGYQYVGCFFRQFRISFGTTPQVWRNQKIRKD"
     gene            complement(2437..4140)
                     /locus_tag="HC643_RS12560"
                     /old_locus_tag="DA73_0400012560"
     CDS             complement(2437..4140)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024986.4"
                     /locus_tag="HC643_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012560"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_038078787.1"
                     /transl_table=11
                     /translation="MDIENLLTQYTSGERNFIGISLRSANLIGINLSGANLSNSKLRDA
                     ELHGANLQRTILRGIDLEGASLRYAVLDEADLSNTNLTNCNFQYASLKRANLINCTILE
                     SSLEGANLEDANLENTVIIDTNLEDTNLKNTNLRNAQVENTSGSPELMHAILCNTIMPS
                     GSICNNNRNPAAIKDTLLLRYARGERDFTNNFSCVELRLSDLQGVNLSDVQLPGIKLWN
                     ASLKDVNMSNANLSGAWLIEIFFLNANLEGINLEESKLSSTSFRGSNLKKANLKGARLD
                     VGEHGFVLTDLINANLTEADLSNANLARAILNKANLTRAILRNTNLSKTDLIRANFSEA
                     DLAGANLSEAIYCSETIFPENVDLSQAIPITSGVDLSGYGKSLLSCKDLHSLDLSRANL
                     SGLYLNDVNFSGTNMSESNLSNTRLSHANLKGTNLAGTNLTNARLAGADLSNADLSYSI
                     VANTDFRGAFYNSATIFPNGIDLSKAIYLVAGANLSHIFFSKINLREVDLSNTNLSNSI
                     LKYIDLSYADLSNANLTNTNFEGAILEGANLSGAIFHKTIMPNGSVRNSY"
     gene            complement(4517..5812)
                     /locus_tag="HC643_RS12565"
                     /old_locus_tag="DA73_0400012565"
     CDS             complement(4517..5812)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="HC643_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012565"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_038078784.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 9e-20, bitscore:
                     69.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNVKLFQKTVTSGAIATTVALVGFVAKVQAATFSLPIEAAAKAT
                     GVDILRDRYGLDGTGITIGVISDSFNTSPNSFDSLGKVDNYATNIADGYLPSNIQVLQD
                     YSDADPTITEDDPTDEGRAILQIVHAIAPGAKLAFYSGAGDVNVISQGIQALGAVGANI
                     IVDDRGLFPQSIPDVPSNLQDLEPPDGPINQAINAVFDRGISYFSSAGNEFPNLPIYGH
                     VNNPNALSVGAVYYGNAQFYTTRSGLTITQGQIEPFSSEGNPGSLKPDVVAPDGLPTSF
                     NLTGEARPYDNPQFFSFFGSSVSAPYTAAVAALLLQANPNATPTEIYNALRNTAESPLS
                     GFDSRYGYGLIRADRAILSLGVQPKPTTIPEPSAVPALLCVSVLIAGVFLQRNQQKSKT
                     RTKSSLSLALVHSSVDQLSYKLQANVFLENYK"
     gene            complement(6195..6398)
                     /locus_tag="HC643_RS12570"
                     /old_locus_tag="DA73_0400012570"
     CDS             complement(6195..6398)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012570"
                     /product="hypothetical protein"
                     /protein_id="WP_038078782.1"
                     /transl_table=11
                     /translation="MQDELNQAISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFVKACVAWSFARNANKSV"
     CDS_motif       complement(6270..6398)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELNQAISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12570_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6195..6269)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12570_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFVKACVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELNQAISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[6269:6398](-)"
                     /alternative_weights="2608.0"
     gene            complement(6676..6885)
                     /locus_tag="HC643_RS12575"
                     /old_locus_tag="DA73_0400012575"
     CDS             complement(6676..6885)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012575"
                     /product="hypothetical protein"
                     /protein_id="WP_038078780.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGIC
                     LGWTHLKPKPCRGWSFVYNANKSV"
     CDS_motif       complement(6757..6885)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12575_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6676..6756)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12575_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2951.5"
                     /monoisotopic_mass="2949.5"
                     /core_sequence="ICLGWTHLKPKPCRGWSFVYNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[6756:6885](-)"
                     /alternative_weights="2969.5"
     gene            complement(6941..7144)
                     /locus_tag="HC643_RS12580"
                     /old_locus_tag="DA73_0400012580"
     CDS             complement(6941..7144)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012580"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(7016..7144)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12580_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6941..7015)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12580_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[7015:7144](-)"
                     /alternative_weights="2608.0"
     gene            complement(7200..7403)
                     /locus_tag="HC643_RS12585"
                     /old_locus_tag="DA73_0400012585"
     CDS             complement(7200..7403)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012585"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(7275..7403)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12585_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7200..7274)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12585_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[7274:7403](-)"
                     /alternative_weights="2608.0"
     gene            complement(7459..7662)
                     /locus_tag="HC643_RS12590"
                     /old_locus_tag="DA73_0400012590"
     CDS             complement(7459..7662)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012590"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(7534..7662)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12590_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7459..7533)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12590_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[7533:7662](-)"
                     /alternative_weights="2608.0"
     gene            complement(7718..7921)
                     /locus_tag="HC643_RS12595"
                     /old_locus_tag="DA73_0400012595"
     CDS             complement(7718..7921)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012595"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(7793..7921)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12595_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7718..7792)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12595_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[7792:7921](-)"
                     /alternative_weights="2608.0"
     gene            complement(7977..8180)
                     /locus_tag="HC643_RS12600"
                     /old_locus_tag="DA73_0400012600"
     CDS             complement(7977..8180)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012600"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(8052..8180)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12600_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7977..8051)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12600_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[8051:8180](-)"
                     /alternative_weights="2608.0"
     gene            complement(8236..8439)
                     /locus_tag="HC643_RS12605"
                     /old_locus_tag="DA73_0400012605"
     CDS             complement(8236..8439)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012605"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(8311..8439)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12605_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8236..8310)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12605_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[8310:8439](-)"
                     /alternative_weights="2608.0"
     gene            complement(8495..8698)
                     /locus_tag="HC643_RS12610"
                     /old_locus_tag="DA73_0400012610"
     CDS             complement(8495..8698)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012610"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(8570..8698)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12610_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8495..8569)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12610_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[8569:8698](-)"
                     /alternative_weights="2608.0"
     gene            complement(8754..8957)
                     /locus_tag="HC643_RS12615"
                     /old_locus_tag="DA73_0400012615"
     CDS             complement(8754..8957)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012615"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(8829..8957)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12615_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8754..8828)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12615_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[8828:8957](-)"
                     /alternative_weights="2608.0"
     gene            complement(9013..9216)
                     /locus_tag="HC643_RS12620"
                     /old_locus_tag="DA73_0400012620"
     CDS             complement(9013..9216)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012620"
                     /product="hypothetical protein"
                     /protein_id="WP_167844671.1"
                     /transl_table=11
                     /translation="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVAWSFARNANKSV"
     CDS_motif       complement(9088..9216)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12620_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9013..9087)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12620_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCLGWSFAKVCVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELKQVISQALDTNTEFNTESTAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[9087:9216](-)"
                     /alternative_weights="2608.0"
     gene            complement(9272..9475)
                     /locus_tag="HC643_RS12625"
                     /old_locus_tag="DA73_0400012625"
     CDS             complement(9272..9475)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012625"
                     /product="hypothetical protein"
                     /protein_id="WP_167844672.1"
                     /transl_table=11
                     /translation="MQDELNKAISQALDTNTEFNTELPAPKTEGELSDEALEEVAGGVC
                     VGWSFIKACVAWSFARNANKSV"
     CDS_motif       complement(9347..9475)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELNKAISQALDTNTEFNTELPAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12625_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9272..9346)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12625_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2590.0"
                     /monoisotopic_mass="2588.3"
                     /core_sequence="VCVGWSFIKACVAWSFARNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELNKAISQALDTNTEFNTELPAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[9346:9475](-)"
                     /alternative_weights="2608.0"
     gene            complement(9529..9732)
                     /locus_tag="HC643_RS12630"
                     /old_locus_tag="DA73_0400012630"
     CDS             complement(9529..9732)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HC643_RS12630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DA73_0400012630"
                     /product="hypothetical protein"
                     /protein_id="WP_167844673.1"
                     /transl_table=11
                     /translation="MQDELNQAISQALDTNTEFNTELPAPKTEGELSDEALEEVAGGVC
                     LGWSFAKVCVKWSFIHNANKSV"
     CDS_motif       complement(9604..9732)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQDELNQAISQALDTNTEFNTELPAPKTEGELSDEALEEVAGG"
                     /locus_tag="HC643_RS12630_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9529..9603)
                     /prepeptide="core"
                     /locus_tag="HC643_RS12630_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.20"
                     /molecular_weight="2670.1"
                     /monoisotopic_mass="2668.4"
                     /core_sequence="VCLGWSFAKVCVKWSFIHNANKSV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQDELNQAISQALDTNTEFNTELPAPKTEGELSDEALEEVA
                     GG"
                     /leader_location="[9603:9732](-)"
                     /alternative_weights="2688.2"
     gene            10001..13288
                     /locus_tag="HC643_RS12635"
                     /old_locus_tag="DA73_0400012635"
     CDS             10001..13288
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017740066.1"
                     /locus_tag="HC643_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012635"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_038078775.1"
                     /sec_met_domain="DUF4135 (E-value: 2.6e-118, bitscore:
                     394.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.6e-67, bitscore:
                     224.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVSQQDLRKIVEQASNIEERLSNCFVPNEAEDNNKLAMSRLKTW
                     CQLVTQGNSEKLAKRLVWDNLDVSTMVRVLGAVRLADGQQLPSWTDTLREALQTDWETA
                     YASVYHCLEAEKPIPFEEVYLPFVHVARQKLIARANANLHLLSEAVHLYLECQLLLKLA
                     SLCAQSLEFEFSQFKAVKQSASISLPEQQASHSNVQYQNFVKDLKAGGLLSFFQKYSVL
                     ARLVATAVDFWVEEKAEFLQRLASDLPSIQQNFQESTGQVVKIQGNFSDSHNQGRSVIA
                     LTFASGLKLIYKPRGLALESAYFQLLTWCNQHFVEMHTKSLHPFKILKLINSTTHGWME
                     YVEHLPCEDETAVERYYQRAGMVLCLLYLLQGNDCHEENLIASGEHPVLVDLETLVHPR
                     AREVNPTEEVEAQSLVNQQFFQDSVLRTGLLPRWELGADGGTAHDISGLGGGNGGEIPI
                     RIQKWQNINTDNMTLEYESGFMSPSANIPLLNGLVVSSHDYVNEIADGFRQMYQFLVHR
                     QEELLAADSPLAALARQKVRFLFRNTQVYGHILEKTLNPKFLQHGVDRSIQLDVLSRAF
                     LAADEKPPIWSILGVEIRAMEQMDIPYFIANSSSDALALNSDLIVKGYFREPSYNRMIS
                     CLQQLNDTDLAQQISIIRGSFYSRVAQGMTSTLSTERASANLNLDALAPITSTQLVQEA
                     VEIAKDLQQRAIYASNGSATWIGMAYLPKAGRMQLQPLSDGLYDGVCGVSLFLAALAKV
                     TGDARFRDVALSALQNIRKPLQDIRDPNIQHKIAKQSGIGGGIGLGSIVYTLVRVSQFL
                     DEPDLLDTANCAASFITQESIASDRSFDTIAGAAGAILGLLTLYQTKANPTVLDRAQAL
                     GYHLLNNRTKSETGFRAWATLEGKLATGFSHGAAGIAYALLRLYKTTQDPVFLEAAEEA
                     IAYERSIFSPTQGNWPDVRNFSLNKSKPSFMTTWCHGAPGIGLARLGSLEILDTAEIRQ
                     EIAVAINTTQQFGLHNIDHLCCGNFGRMEVLLVGACKLSRSDLWDTVQKQAAWVVARAK
                     QAGSFSLFPELSGDVYNPGFFQGSAGIGYELLRLAYPESLPSVLLWE"
     CDS             13279..13386
                     /gene="allorf_3169861_3169968"
                     /locus_tag="allorf_3169861_3169968"
                     /protein_id="allorf_3169861_3169968"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGVDSCRFVLATLTEAVLAASTCTHSFIYSIVVAF"
     CDS_motif       13279..13338
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGVDSCRFVLATLTEAVLAA"
                     /locus_tag="allorf_3169861_3169968_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13339..13386
                     /prepeptide="core"
                     /locus_tag="allorf_3169861_3169968_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.60"
                     /molecular_weight="1584.8"
                     /monoisotopic_mass="1583.8"
                     /core_sequence="STCTHSFIYSIVVAF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGVDSCRFVLATLTEAVLAA"
                     /leader_location="[13278:13338](+)"
                     /alternative_weights="1602.8"
                     /alternative_weights="1620.9"
                     /alternative_weights="1638.9"
                     /alternative_weights="1656.9"
     gene            13524..14435
                     /locus_tag="HC643_RS12640"
                     /old_locus_tag="DA73_0400012640"
     CDS             13524..14435
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="HC643_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012640"
                     /product="histidine kinase dimerization/phosphoacceptor
                     domain-containing protein"
                     /protein_id="WP_050045728.1"
                     /transl_table=11
                     /translation="MNYWLKTQSHPIRCLLYLEWGFLAIASMASFLELVLAPQIWQHKV
                     SDLLVLAVFALLGVTSYIDKFATKTIYVCMHFSLVLIWLPFSGALWLLSILLLILMIRC
                     FFMLPLQGRWIIAGLAFGIVLLARMQQLYSTHKLLAFSQLSQQWMSQWSDVFWFGIVLL
                     LLTQLMQQVLITQQIQQQLAREQQRWRQYIQQQQKLIALQARHHVACESYDALGHALAA
                     INIQIQSALKFWSIDPNQAQEFLTQAQRVGVTTMQEIRNSLRALRIHTIPPQIQLPLEQ
                     KHDVTVSFSPQDYLAMNYNKRI"
     gene            14827..15915
                     /locus_tag="HC643_RS12645"
                     /old_locus_tag="DA73_0400012645"
     CDS             14827..15915
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016868934.1"
                     /locus_tag="HC643_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012645"
                     /product="DUF3365 domain-containing protein"
                     /protein_id="WP_272899737.1"
                     /transl_table=11
                     /translation="MWTKIKKAILYHSKLTTKFTLLLSIVFIGAILISSFALSKALEQR
                     SEDEINYRGQVIMQMINSLREYTTINITTLLTSNPDNQQNFIPEIVPSFAVREVFENLR
                     KNKEYRDYYYKDATLNPTNLRDKADDFETNLINKFRDRPNLQILSGFRDLYGEKVFYSA
                     RPFTIKKSSCLQCHSTPEIAPKNHLKTYGTENGFGWKLNEIVASQVVYFPVSEVYNRAS
                     QAFSLFIAIFIGVFTLVLLTINLLLKRNVIDPLKPMAQLAQKISTNTFVYSQAEEFEFK
                     NLVAIAKRTDELGHLGRIFLRMVCEVYDREQRMKQQMRELSIRINETKKAREVSEIVEA
                     DYFQNLSAQAKAIRNNWANSDE"
     gene            15991..16821
                     /locus_tag="HC643_RS12650"
                     /old_locus_tag="DA73_0400012650"
     CDS             15991..16821
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1157: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016868931.1"
                     /locus_tag="HC643_RS12650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012650"
                     /product="MinD/ParA family protein"
                     /protein_id="WP_038078771.1"
                     /transl_table=11
                     /translation="MSKIVSIHSFRGGTGKSNVTANLATIMARSGKRIGIVDTDIQSPG
                     IHVLFGLNEEKIGYTLNDYLWGRCAIENAAYDVTQILNLSHKGAAIGGSIHLIPSSIKT
                     GEISRILREGYDARLLNDSFRNLSRRLKLDYLFIDTHPGINEETLLSIIISHVLVIILR
                     PDHQDYQGTAVTVDVARKLEVPKMLLVVNKALPSLNFQAIAQQMQKSYNTTVASILPVS
                     EEMFQLGSRDVFCLRYPNHPWTQGVSAIAKQILFEDNKSSMNFKTPLSWFNGRR"
     gene            complement(17352..20288)
                     /locus_tag="HC643_RS12655"
                     /old_locus_tag="DA73_0400012655"
     CDS             complement(17352..20288)
                     /GO_function="GO:0015440 - ABC-type peptide transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016862206.1"
                     /locus_tag="HC643_RS12655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012655"
                     /product="NHLP bacteriocin export ABC transporter
                     permease/ATPase subunit"
                     /protein_id="WP_038078768.1"
                     /transl_table=11
                     /translation="MVEQIKFGIAQQQYIIKGNEPILLDDRETVWVVKSGSLALFSIKV
                     KHGIAEGSRRYLFNVEASEAMFSTTPSSQDEVCQILAVSMEETELIRVPVEDFSKWIVK
                     GDRQAIALVENWIHRFSSLLSDVTAPTMPVQPEGINYFSLGSGDIFQPQHDTVTWVQIQ
                     QGCVNWMGFEELPLLPLSGILPLDSKMWLQATDEVELSSEDISAIQDADTLADSLTLLA
                     TYFLDYIQLLEQQEISAELRRFQERERLNYQVMKETLGELSSVLQQRKTVFYPAVTPTS
                     DPDEALLIAAGAVGRALGVTIRPPAKSENITRIQDPLEAIARASQIRMRRIALTDRWWK
                     KDSGPMLTYTIEDNHPVALLPLSDNRYEIFDPVAQTRTPVNARTTSKLVPNAYVFYRPL
                     PEKKLKTWDLLKFALQGHSRELIVILCTGIATTLLGMLTPTATAILIDNAIPDAKREVL
                     IQIALGLLAAAFGESIFQLTQGFAIIRLETFADASTQAAVWDRLLNLRASFFRQYSIGD
                     LNSRVNAVTQIREKLSSTVLKTIFSSLFSLLNLGLLFYYNVSLALIACVVALVNIGVTV
                     VSGILTLHKVRPLLEIEGEISGVMVQLIDGVAKLRVAGAEARAFAYWGKQYSQQLKLML
                     STQGIEDFLTVTNKVLPPLTNAILFWFAVQTLNTTSGQQLNAGALSTGTFLAFNSAYAT
                     FISGATSLSSTVVDVLEVLPLWNRAQPILSATPELNSSKTDPGRLSGRVVVDHVVFRYG
                     NDGPLTLDDVSIRAEPGEYIAIVGPSGSGKSTLFRLLLGFDFPESGTIYYDGQDLAGLD
                     VNAVRRQLGVVIQNSRMMSGSIFENIASGALVTMDEAWEAARASGLADDIEAMPMGMHT
                     VVSEGGSNLSGGQRQRLLIARALVLKPRILLFDEATSALDNRTQAIVSQSLERLQVTRI
                     AIAHRFSTIRNANRIYVLQSGRVVQHGSFEELAHQQGLFSQLMARQML"
     gene            complement(20376..22628)
                     /locus_tag="HC643_RS12660"
                     /old_locus_tag="DA73_0400012660"
     CDS             complement(20376..22628)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017745254.1"
                     /locus_tag="HC643_RS12660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DA73_0400012660"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_038078767.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.3e-36, bitscore:
                     122.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLRNLFFWRKRIRRRTPTLLQMEAVECGAAALGIILGYYGRIVA
                     LSRLRQDCGVSRDGSKASNILNAARSYGLKAKGFKIDLEALQELECPYIVFWNFNHYLV
                     VEGFGRERVYLNDPASGVRTVSLQEFSDAYTGVVLVLEPGPGFKKGGRKPNTLLALWQR
                     LQKSGGALAYSVFAGFLLVIPGLAIPTFSQVFIDNVLIEGRNDWLRPLILGIVLVAGLM
                     GFLTLLQLQSLRHMKIKLSVGMSSQFLWHILRLPVSFYDQRFAGEISNRVQLNDKLADI
                     LSGKLATTAIAAVTVVFYAAVMLQYDTVLTSIGIAFVAVNLLALQWVRRWRVDANMRLQ
                     QDEGKVAGVSISGLQSMETLKASGLESDFFSRWAGYYAKSINAKQEMDVTNQTLGVLPS
                     FLSTLSSMLLLVVGGFRVIDGYLSIGMLVAFQSLMQAFLQPVNELVTLGSNLQEVEGDL
                     NRLDDVLRNPIDSQLEQGEKDKRKGGKKAREQGENDGLLSLPPSLSHAKLQGYVELKNI
                     TFGYNRVAPPLIENFNLSLKPGQRVALVGGSGSGKSTIAKLVCGLYEPWEGDICFDGKL
                     RGQIPRQVLANSIALVEQDIFLFAGSVRDNLTLWDTTVPDNYIMRACQDAAIHDVVLSM
                     PRGYSTHLLEGASNLSGGQRQRLEIARALVNNPTILVMDEATSALDTETEKIIDRKLRQ
                     RGCTCIIVAHRLSTIRDCDEIIVLERGKVVQRGTHEELKNIEGAYLQLIRSEGEAL"
     misc_feature    22969..22979
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    23152..23168
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.52"
                     /tool="antismash"
ORIGIN
        1 aagtcattgt tctcagtacc tttgatgatg atgaatacat taccgagtcg atacgggctg
       61 gagcaaaggg ttatttgctc aaagatatgt tatctgaaga attggcagag tcaattcggt
      121 ttgtccatcg cggttactca caattagctc ccggactgct ggaaaagttg gtcactcaag
      181 ctgcggattc agcatcgagg cgtagcgaga caactccaac agttttggct gagttaactg
      241 ctagggaacg agatgtgttg cgcttaattg gtaggggtgc taccaatcgc gaaattgctc
      301 agcagcttat tatctccgaa ggtacggtga agacttacgt taccaatctt tttaaccgtt
      361 tgaacttgaa gaaccgctcg cagcttgcca tttatgctaa ttctgtaagc tggaatgaaa
      421 gttaggacaa acattgacga aagttttaag aagatctact tattggcaaa ctttagtcag
      481 ggtgaattta tctatttgtt gaagtagaaa ttaagacatt tttcagatga ttattagtag
      541 ttaacaattt aggatagaag tataaagtga ttgaaaagta tttttatcaa aactagatta
      601 tgtttgttcg cgatatcaac aaatgccaac agcctttctt gactttacaa agggcacaag
      661 aagcaccaga acaaaaagtg cgaaagcttc ttgctaaatt aagttatatg aacgagcaat
      721 tatgtcatga gaaagcttta cgtttgcggg cggaggcgga actagaaaag tctcttgcat
      781 tgacaaagaa agagccatta gtttctatga tttgccatga attccgttct tcactgaacg
      841 ttatctcctt ctccactagt ttacttaaac gtcaccatca caattggagt gaggagaaaa
      901 cactacagta tttccagcgt cttcaaacaa cagtcgaaca gctcggtcaa ctgatggacg
      961 aacttctaac gatcgagaga gcagaagcag gaaagctaga gtttgagcct acatcggtta
     1021 atttgatctc attctgccat gatatattaa ctcaaatgaa tttgagtgaa aactctcaga
     1081 acgcaattaa ttttgtgata caaggtgata gcaaagcagt ttgtatagat aaaaaattat
     1141 tgcagcctgt tcttacgaat ttattatcga acgcgattaa atattccccc aatggtagta
     1201 cagttgatat gatactctcc tatctagatg aagaagttat ttttacgata aaagataggg
     1261 gaattggcat tccaaaagca gatcgacaac ggctgtttga gccatttcat cgtggtggaa
     1321 atgtcggtga taaaccgggt actggattgg gtttagcaat tgtcaaaaaa tttgtggata
     1381 tacatggtgg ggaaatcatt atagagagtg aagtgggtgt tggtactacg tttacgatcg
     1441 cattgccatg ccaaatgtgt cactaatacc tacacagtga ggtaatacca acttgagaaa
     1501 agaaggcaac aaataattga gcgaaattaa gtccaagcag gactttgtca atctataatc
     1561 gaaaatccaa aatatacaaa ctatgacaaa agttttagta attgaagatg aagtagaaag
     1621 tcgaaatata tttcttgaat gcctcgaagc agaagggttt gatactatca gtgcagaaaa
     1681 cggtctgata ggcgttcaga aagcacaaga aaacttgccc gacctcatta tttgtgacgt
     1741 ttccatgcca gaattagatg gttatggtgt cctcacctca ttacgccaaa acacgggaac
     1801 agcaaggatt ccctttattt ttcttagtgc caagagtaca aaggctgagg tgcgtcaagg
     1861 catgacgctt ggtgctgatg actatctcac caagcctact acagcagagg aattattaga
     1921 agcgatcgct acccgactga aaaaacaagc aactattaag gagtggtacg agactcaatc
     1981 accacaagtc acaccacctc ctgctaatac cgctccatca gccgactccc agtcatcctc
     2041 tcctgctagc cctcagttga aggaggtttt tgactttatc gaagccaatt atcaccaagc
     2101 tataagctta agtgacgtag cccaagccgt gggttattcc ccagcatact taactgactt
     2161 aatgcgacgc caaacaggaa agacggtaca tcaatggatc gtagagcacc gaatgacaaa
     2221 ggcatgctca ttgcttttgg aaaccaagca gtcagtagaa cagattgcgg aagcagtggg
     2281 ttatcaatat gtagggtgtt tctttcgtca atttcgtatc agctttggaa ctacccctca
     2341 agtttggcgc aaccagaaga tacgcaaaga ttgaagtcag gggcttccac ataaggaata
     2401 tctcaaaatt tcttattatt aatagaaatt tatttattaa tagctattcc taacactacc
     2461 attaggcatg atagttttat gaaatattgc tcctgacaaa tttgcacctt ctaaaattgc
     2521 accttcaaag ttagtattag tgagattagc gttgctgaga tcggcataac ttaaatcaat
     2581 atatttcaaa atagaattac ttaagtttgt attagataaa tcaacttcac gtaaattaat
     2641 tttactaaaa aagatatgag atagatttgc acctgctaca agatatatag cttttgataa
     2701 atcaatacca ttaggaaaaa tagtagctga attataaaat gctcccctga aatcggtatt
     2761 agctactata ctgtagctga ggtcagcatt acttaaatca gccccagcta aacgagcatt
     2821 tgtaaggtta gtacctgcta agtttgtacc ttttaaattt gcatgactta aacgagtatt
     2881 actaagatta gattcactca tgttagtacc gctaaaattt acatcattta aataaagacc
     2941 acttaagtta gctctactta aatcaagtga gtgtaaatct ttgcaagata aaagagattt
     3001 gccatatcca gacaaatcta caccagaggt aattggtata gcttgggata aatccacatt
     3061 ttcagggaaa attgtttctg aacagtaaat tgcttcactt aagtttgccc ctgctaagtc
     3121 tgcttcacta aaattggcac gtattaaatc agtcttactg agatttgtat ttcttaatat
     3181 agctctggtt aaatttgctt tattcagtat tgctctggct aaattggcat tacttaaatc
     3241 ggcttctgtt aagttagcat ttattaaatc tgttaaaaca aaaccatgtt cacctacatc
     3301 taatctagct ccttttaagt tagctttttt taaattactt cctctaaaag atgtgctact
     3361 taatttgctt tcttctaaat tgataccttc taaattagca tttaggaaaa aaatttcaat
     3421 taaccaagca ccacttaagt tcgcattact catatttaca tcttttaaag aagcattcca
     3481 tagttttatg ccaggaagct gtacatcact taaatttact ccttgcaaat cagaaagcct
     3541 taattctaca caactaaaat tattagtaaa atctctttct cctcgtgcat agcgtagcaa
     3601 caaagtatcc ttaatcgccg ccggattacg attattgtta caaatactac cgcttggcat
     3661 aatagtgttg cacaaaatag catgcattaa ttctggagag ccacttgtat tctcaacttg
     3721 agcattacgt aaattcgtat ttttcagatt tgtatcttca agatttgtgt caattattac
     3781 tgtattttct agatttgcat cctctagatt tgctccttct aaactgcttt caagtattgt
     3841 acaatttatt aaattcgccc tttttaagct ggcgtactga aaattgcagt tagttaaatt
     3901 ggtattactc aaatctgctt catctagaac tgcgtagcgt aagctagcac cttctaaatc
     3961 aatgcctcta agaatagttc gttgaagatt agctccatgt aactcggcat ctcttaactt
     4021 agagttgctt aaattagcac cgctcaagtt aatccctatt aaattggcac tccttaaact
     4081 aatgcctata aaatttcttt ccccagaggt gtactgtgtg agtaaatttt caatatccat
     4141 acataactca aataaattgt ttaaatacta ataacagtat ctccttataa gataaatcct
     4201 gccactaagt taagtgcaac cttgcaagaa atgtacgcag cactggctac tgaaagcttt
     4261 gctatccctc aactatgaca attaatgtaa gaattttcgc actggatttt ctgacttagt
     4321 caagcctgaa ataagggcaa taacaaattt agacattgag attaaccaaa ttccgtgtta
     4381 ttgcaatact gctctgcggg ttcatgtgct tatacgtact tagtaatttc ccaccctatt
     4441 ttcccttaac cgagcagtag taaattccat ttataaagga cgggtaagaa aacccgtccc
     4501 aaaatcaggg attttactat ttgtagtttt ctaaaaagac gttggcttgt agcttgtacg
     4561 aaagttgatc aacgcttgag tgaactagag caagactcaa gctagactta gttctggttt
     4621 tagacttttg ctgattgcgt tgcagaaaga caccagcaat taaaacactg acacacagca
     4681 aagcaggaac tgccgaaggt tcggggatag ttgttggttt aggctgaact cccagcgata
     4741 agatcgctcg atctgctcga atcaaaccat aaccatatct ggaatcaaaa ccggacaaag
     4801 gactttcagc tgtatttctc aaagcgttat agatttcagt aggcgttgcg ttcggatttg
     4861 cctgtagtag cagcgctgcg actgcagcag tatacggagc agacaccgaa cttccgaaga
     4921 agctaaagaa ttgaggattg tcataaggac gagcttctcc agtcaagttg aaagaagttg
     4981 gtagaccatc cggagctaca acatccggtt ttagagatcc tggattccct tccgaagaga
     5041 aaggctctat ttgcccctgc gtaatagtaa gaccagatcg agttgtgtaa aactgtgcat
     5101 tcccatagta cacagctccg acactcaatg catttgggtt attgacgtgc ccgtatattg
     5161 gtaaattggg aaactcatta cctgcggaac taaagtaaga aattccccga tcgaagactg
     5221 cgttaattgc ttggttgatc ggtccgtctg gcggctccaa atcctgcaag tttgaaggta
     5281 catcaggaat actttggggg aataaacctc tatcatccac aataatattg gctccgacag
     5341 cccctagagc ttgaataccc tgactaataa catttacgtc tcccgcaccc gagtaaaacg
     5401 ctaatttagc gcctggagct atagcatgaa cgatctgcaa gatagcgcga ccctcatctg
     5461 taggatcgtc ctcagtaatg gtagggtctg catctgaata gtcctgtaaa acttgaatat
     5521 ttgagggtag gtaaccgtcg gcaatattag tggcatagtt atcgaccttc cccaaactgt
     5581 caaaactgtt tggcgaagta ttaaagctgt cagatattac accgatggtg attccagtac
     5641 catccaaacc atagcgatcg cgtaaaatat cgactcctgt ggctttggca gcggcttcaa
     5701 ttggtaagga gaaggtagct gcttgaacct tggcaacaaa gcctaccagg gcaacagttg
     5761 ttgcgatcgc ccctgaagta acagtttttt gaaagagttt cacatttttc atagcgttta
     5821 caaaccttca caagattttt cgtaaaacgt aaaattttat acttattttg tctggttaag
     5881 cttacactta aaccattagc tttccgtact atcgtgcctt ctgcttcttt aggagtattt
     5941 agcgtgcaat ttctacataa aagctacagc ttgaaaggac aacgaatacg gaaactagaa
     6001 tatcaatata aaaactacaa cttcaatttg aattctttag gaaagacaat caaaaaaatt
     6061 aacagtcatt gaatgagaga cttaagtgct aattatgcaa caaaacccag tgaacgaaga
     6121 agaattctct ataaaagttc actgggttat aacaatttgt cactggacgt aattaccaaa
     6181 aagttcagtt tagcttagac ggatttgttg gcgttccggg caaaactcca agcaacgcaa
     6241 gcttttacga aactccaacc cagacatacg ccacctgcaa cttcttcgag agcttcatca
     6301 gataattcgc cttcggtctt gggtgcagtt gattccgtgt tgaactcggt gttggtatcg
     6361 agagcttgag agatggcttg attgagttcg tcttgcattt ttttgtctcc tattttttaa
     6421 tttgttgagc gagtgaaagt cagtagctcg caaacttggg taaatcaatg tagaaataag
     6481 ggtttcagcc attgtcactc tgataggtaa agagcatttg tttaatagaa atcgccttgt
     6541 gaaagtgaag gtcgtgacct tggccgaaat actgatgaga atgtgttttc tcaatacaag
     6601 agcgtcctac taaaatcttc atgtagtaac acttctaaaa actttgcgat ctactgacag
     6661 taattggtat aagtcttaga cggatttgtt agcgttataa acaaaactcc aacccctgca
     6721 aggttttggt tttagatgag tccaacccag acatatgcca cctgcaactt cttcgagggc
     6781 ttcatcggat aattcgcctt cggtctttgg tgcagttgat tccgtgttga actcggtgtt
     6841 ggtgtcgaga gcttgagaga taacttgttt gagttcgtct tgcatttttt tgtctcctat
     6901 tgtttcaatt tgtcaaatga gtgaattgtt gagctaaatc ttaaacggat ttgttggcgt
     6961 tccgggcaaa actccaagca acgcaaactt ttgcgaaact ccaacccaga catacgccac
     7021 ctgcgacttc ttcgagggct tcatcggata attcgccttc ggtctttggt gcagttgatt
     7081 ccgtgttgaa ctcggtgttg gtgtcgagag cttgagagat aacttgtttg agttcgtctt
     7141 gcattttttt gtctcctatt gtttcaattt gtcaaatgag tgaattgttg agctaaatct
     7201 taaacggatt tgttggcgtt ccgggcaaaa ctccaagcaa cgcaaacttt tgcgaaactc
     7261 caacccagac atacgccacc tgcgacttct tcgagggctt catcggataa ttcgccttcg
     7321 gtctttggtg cagttgattc cgtgttgaac tcggtgttgg tgtcgagagc ttgagagata
     7381 acttgtttga gttcgtcttg catttttttg tctcctattg tttcaatttg tcaaatgagt
     7441 gaattgttga gctaaatctt aaacggattt gttggcgttc cgggcaaaac tccaagcaac
     7501 gcaaactttt gcgaaactcc aacccagaca tacgccacct gcgacttctt cgagggcttc
     7561 atcggataat tcgccttcgg tctttggtgc agttgattcc gtgttgaact cggtgttggt
     7621 gtcgagagct tgagagataa cttgtttgag ttcgtcttgc atttttttgt ctcctattgt
     7681 ttcaatttgt caaatgagtg aattgttgag ctaaatctta aacggatttg ttggcgttcc
     7741 gggcaaaact ccaagcaacg caaacttttg cgaaactcca acccagacat acgccacctg
     7801 cgacttcttc gagggcttca tcggataatt cgccttcggt ctttggtgca gttgattccg
     7861 tgttgaactc ggtgttggtg tcgagagctt gagagataac ttgtttgagt tcgtcttgca
     7921 tttttttgtc tcctattgtt tcaatttgtc aaatgagtga attgttgagc taaatcttaa
     7981 acggatttgt tggcgttccg ggcaaaactc caagcaacgc aaacttttgc gaaactccaa
     8041 cccagacata cgccacctgc gacttcttcg agggcttcat cggataattc gccttcggtc
     8101 tttggtgcag ttgattccgt gttgaactcg gtgttggtgt cgagagcttg agagataact
     8161 tgtttgagtt cgtcttgcat ttttttgtct cctattgttt caatttgtca aatgagtgaa
     8221 ttgttgagct aaatcttaaa cggatttgtt ggcgttccgg gcaaaactcc aagcaacgca
     8281 aacttttgcg aaactccaac ccagacatac gccacctgcg acttcttcga gggcttcatc
     8341 ggataattcg ccttcggtct ttggtgcagt tgattccgtg ttgaactcgg tgttggtgtc
     8401 gagagcttga gagataactt gtttgagttc gtcttgcatt tttttgtctc ctattgtttc
     8461 aatttgtcaa atgagtgaat tgttgagcta aatcttaaac ggatttgttg gcgttccggg
     8521 caaaactcca agcaacgcaa acttttgcga aactccaacc cagacatacg ccacctgcga
     8581 cttcttcgag ggcttcatcg gataattcgc cttcggtctt tggtgcagtt gattccgtgt
     8641 tgaactcggt gttggtgtcg agagcttgag agataacttg tttgagttcg tcttgcattt
     8701 ttttgtctcc tattgtttca atttgtcaaa tgagtgaatt gttgagctaa atcttaaacg
     8761 gatttgttgg cgttccgggc aaaactccaa gcaacgcaaa cttttgcgaa actccaaccc
     8821 agacatacgc cacctgcgac ttcttcgagg gcttcatcgg ataattcgcc ttcggtcttt
     8881 ggtgcagttg attccgtgtt gaactcggtg ttggtgtcga gagcttgaga gataacttgt
     8941 ttgagttcgt cttgcatttt tttgtctcct attgtttcaa tttgtcaaat gagtgaattg
     9001 ttgagctaaa tcttaaacgg atttgttggc gttccgggca aaactccaag caacgcaaac
     9061 ttttgcgaaa ctccaaccca gacatacgcc acctgcgact tcttcgaggg cttcatcgga
     9121 taattcgcct tcggtctttg gtgcagttga ttccgtgttg aactcggtgt tggtgtcgag
     9181 agcttgagag ataacttgtt tgagttcgtc ttgcattttt ttgtctcctg ttgtttcaat
     9241 ttgtcaaatg agtgaattgt tgggctaaat cttaaacgga tttgttggcg ttccgggcaa
     9301 aactccaagc aacgcaagct tttatgaaac tccagcccac acatacgcca cctgcaactt
     9361 cttcgagggc ttcatcggat aattcgcctt cggtcttggg tgcggggagt tctgtgttga
     9421 actcggtgtt ggtgtcgaga gcttgagaga tggctttgtt gagttcgtct tgcatttttt
     9481 tgtctcctat tgttttaatt tgtcaaatga gtgaattgtt gagttaagtt agacggattt
     9541 gttggcgtta tgaataaaac tccacttaac gcaaactttt gcgaaactcc aacccagaca
     9601 tacgccacct gcaacttctt cgagggcttc atcggataat tcgccttcag tcttgggtgc
     9661 ggggagttct gtgttgaact cggtgttggt gtcgagagct tgagagatag cttgattgag
     9721 ttcgtcttgc attttcctgt ttcctatttt ctaatttgtt tctgtcaatt tatctttgat
     9781 acttatcaga atagcgatat gtaaataaaa gcgtcaattt gattttttta ggaagacaaa
     9841 caaaaaaaat aagagtaaat aataacagga aaacttttag actataaaaa ttgcagtctt
     9901 ttctaaaaaa attgaattgt aattcttgtt ttaattttct aaactaaata tcgaaagaga
     9961 atcagtcaag tattttggca atcagatagg gtaaacataa atggaagttt cacaacaaga
    10021 tttacgaaaa atagtagaac aagctagtaa tattgaagaa agattgagca attgctttgt
    10081 tccaaatgaa gctgaagaca acaataagct ggctatgtct cgcttgaaaa cttggtgtca
    10141 gcttgttaca caagggaatt cagaaaagtt agccaaacgc cttgtatggg acaatctaga
    10201 tgttagtaca atggttaggg ttctcggtgc tgtccgcctt gctgatgggc aacaactccc
    10261 ctcatggaca gacactttgc gggaagcttt gcaaactgat tgggaaacag cttatgcaag
    10321 cgtctatcat tgtttggaag ctgaaaagcc aattcccttt gaagaagttt atctaccctt
    10381 tgttcatgta gcgcggcaaa aacttattgc acgagctaat gctaatttgc acctgctgtc
    10441 cgaagcagtt cacttatatt tggaatgtca gctactatta aaattagcgt ctctttgcgc
    10501 tcaatctcta gaatttgagt tttcacaatt taaagcagtg aagcagtctg cgtccatatc
    10561 tttaccagaa caacaggcta gccattctaa cgtacagtac caaaattttg ttaaagactt
    10621 gaaagcggga gggttattat cttttttcca gaagtacagt gttctagcgc gattggtggc
    10681 aacagcagtg gatttctggg tagaggaaaa agcggaattc cttcagcgtt tggcatcaga
    10741 tttacccagc atccagcaaa acttccaaga aagtacaggt caagtcgtta aaatccaagg
    10801 aaatttctct gactctcaca atcaaggacg ctccgtcata gcgctgacct ttgcatccgg
    10861 cttaaaactc atatacaaac ctagaggctt agccttggaa agtgcttatt ttcagttact
    10921 gacttggtgc aatcagcatt ttgtagagat gcatacaaag tctttgcacc cgttcaaaat
    10981 actaaaactt atcaacagca ccacccacgg atggatggag tatgtagagc atttaccttg
    11041 tgaagatgaa actgctgtag agcgatacta ccaacgtgct gggatggttt tgtgcctgct
    11101 ctacctgctg caagggaacg actgccatga ggaaaatcta atcgctagtg gggaacatcc
    11161 ggtgctagtt gatctagaaa cacttgtaca tcctcgtgct cgtgaggtta accctacaga
    11221 ggaagtagaa gcgcaatctt tagtaaatca gcaatttttt caagattcgg tgctgcggac
    11281 tggactgtta ccaagatggg aattgggcgc agatggagga actgctcacg atattagtgg
    11341 tttggggggt ggaaatggcg gggaaattcc tattcgcata caaaagtggc agaacattaa
    11401 cactgacaat atgacattgg aatacgagtc tggtttcatg tcaccctctg ctaatatacc
    11461 tctccttaat gggctcgttg tgtcatccca cgattacgtc aatgaaatcg cagatggttt
    11521 tcggcagatg tatcagttcc tggtacacag gcaagaagaa cttttagcag ctgacagtcc
    11581 attagccgcc ctagcccgtc agaaagttcg atttttgttt cgcaataccc aagtatacgg
    11641 tcatattcta gaaaaaactc ttaatccgaa gtttttacaa catggtgtag atcgcagtat
    11701 tcaactagat gtcttaagtc gggcattttt ggcagccgat gaaaaacccc caatttggtc
    11761 aattcttggg gttgagatcc gagcaatgga acaaatggat attccttatt tcattgctaa
    11821 ctccagtagt gatgctctgg cacttaattc agatctaatt gttaagggat attttagaga
    11881 acctagctat aaccgaatga tttcttgtct gcaacagctt aatgacacag atttagctca
    11941 acaaatctca atcattcggg gttcttttta ctcgcgggtt gctcaaggaa tgaccagtac
    12001 tctatccacc gagcgtgcta gtgctaatct aaatttggat gcacttgctc ccataacatc
    12061 aacacaactg gtgcaggaag cggtagagat tgcaaaggac ctgcaacaac gagcaatcta
    12121 cgcctccaat ggtagcgcta cttggattgg gatggcatat ctccccaagg caggacggat
    12181 gcaacttcag cctttaagtg atggtttata tgatggtgtt tgtggagttt ctttattttt
    12241 agcagcgctg gcaaaagtaa ctggtgatgc aagatttcgc gatgtagcat tgagcgcctt
    12301 acaaaacata agaaagccct tgcaggacat acgagaccca aacattcagc ataaaattgc
    12361 caagcaaagt ggtatcggtg gcggcattgg attggggtct atagtgtata ctttggtacg
    12421 agtcagtcag tttctagatg aaccggatct gttggacact gccaattgtg ccgcttcgtt
    12481 catcactcag gaaagcattg ccagcgatcg ctcatttgac acaatagcag gagcggctgg
    12541 agcaatactg ggattactga ctctgtacca aacaaaggca aacccaactg ttctcgatcg
    12601 cgcacaagct ttgggttatc atttactcaa caaccggact aagagtgaga ctggatttag
    12661 agcttgggct accctagaag gcaagttagc aacgggattt tcccacggtg cagctggtat
    12721 tgcctacgct ttattacgat tgtataaaac cacacaagac ccagtttttc tagaagcagc
    12781 agaggaagcg atcgcctacg aacgcagtat cttttcaccc actcaaggaa actggccaga
    12841 tgtaagaaat ttctccttaa ataagagcaa gccatctttt atgacgactt ggtgtcacgg
    12901 tgctcctggt attggtttag cccgtttggg gagtctggag attctggata cagcagaaat
    12961 tcggcaagaa attgcagttg ctataaatac aacacagcag tttggtttac acaatattga
    13021 ccatctctgt tgcggtaatt tcggcagaat ggaagtttta ttggtgggag cgtgcaagct
    13081 gtcgcgttcg gatctttggg ataccgttca aaaacaagca gcttgggttg ttgcaagagc
    13141 aaagcaagct ggtagttttt ctctgtttcc cgaactttct ggagatgttt ataaccctgg
    13201 tttctttcaa ggtagtgctg gaatcggtta tgaactcttg aggctagcat atccggaatc
    13261 gcttccttcc gtattgttgt gggagtagat agctgtcgtt ttgtccttgc tactctcaca
    13321 gaagccgtcc ttgcggcttc tacttgtact catagtttta tctactcaat agtggttgcc
    13381 ttttaacact aaagtgcaac tacaaaccaa aaagctataa atcgaaagat ttgcaagtcc
    13441 gatcgaaacg ttgtgcattg cgataagccg gaggcttaac ggagtacagc cgtatcgcag
    13501 gttactttct ctatactgct actatgaatt actggcttaa aactcaatct catcccatcc
    13561 gctgtttgct ttacttggaa tgggggttcc ttgcgatagc aagcatggct agctttctcg
    13621 aacttgtatt agcaccacaa atatggcagc acaaagtctc agatctgctc gtgctggctg
    13681 tatttgcatt acttggcgtt acctcataca tagataaatt tgctactaaa actatctatg
    13741 tatgcatgca ctttagtcta gttttgatat ggctaccttt tagcggagcg ttgtggctgt
    13801 tatcaattct gttactaatc ctcatgattc gctgtttctt tatgttgcca ttgcaagggc
    13861 gttggataat agcggggtta gcttttggaa ttgtgttgct tgcacgaatg caacaacttt
    13921 acagcactca caaactcctt gcgttcagcc agttatcgca acaatggatg agccagtgga
    13981 gcgatgtttt ttggtttgga attgtgttgt tattacttac gcaattaatg cagcaggtgc
    14041 taataacgca acagattcaa cagcaactag cacgagagca acaaaggtgg cgacaatata
    14101 tccaacaaca gcaaaaactc attgcactcc aagcacgaca ccacgttgct tgcgaaagct
    14161 atgatgcttt gggtcacgcg ttagcagcca tcaacattca gatacaaagc gctctgaaat
    14221 tctggtctat cgatccgaat caagcacaag agtttttaac acaagcgcaa cgggtgggag
    14281 tcaccactat gcaggaaatt cgcaattctc tccgtgcgct acgcatccac actataccac
    14341 cacagataca actcccattg gaacagaaac acgatgtgac agtttctttc tctcctcaag
    14401 attacctagc aatgaattac aacaaacgca tctaactaca ggggatatgg atcgtttgca
    14461 tctgaaaaga gcgtagaaag gttgcaatac gctgtaagct acagtttttt atgactttaa
    14521 ttttaagtaa ttatacttct tgactcgact ttagtcagag gaaatttgtc tattgcgtcc
    14581 atctagaatt caagacgttt ttcagatgtt tgatttggct tgaatctcta cgattgatat
    14641 agttccttat ctcagtttac tacaggagtt ttatttaatt ttttaaatac aaatagggta
    14701 agctttgcta tcacatagtg cttgagataa tgtttactct aaagtaatta agatgaagaa
    14761 aaaacagcaa taaaatttta tctaatcaag aattgtcatt gactttaata ttggtagtta
    14821 attattatgt ggacaaaaat taaaaaagcg atattatacc attccaagct tactaccaaa
    14881 tttactctac ttctttcaat cgtttttatt ggtgctatct taatcagtag ttttgcttta
    14941 tctaaagcac ttgagcaaag atcggaagat gaaataaatt acagagggca agttatcatg
    15001 caaatgataa attcattaag agagtataca accatcaata taacaactct attaacctct
    15061 aatccagata atcaacaaaa ttttatccca gaaatagtac cgagttttgc agttagagag
    15121 gtatttgaaa atttacgtaa aaataaagaa tatagagatt attattacaa agatgctact
    15181 cttaatccca ctaatctacg agataaagcg gatgattttg aaacaaatct tataaataag
    15241 tttcgcgatc gaccaaattt gcaaatctta tcaggatttc gagatttgta tggagaaaaa
    15301 gtgttttata gtgctcgtcc ttttactata aaaaaatcca gttgtcttca atgccatagt
    15361 actccggaaa ttgcacctaa aaatcattta aaaacttatg ggacagagaa tggttttggc
    15421 tggaagctca atgaaattgt tgcatctcaa gttgtttatt ttcccgtaag tgaggtttat
    15481 aacagagctt ctcaggcttt ttctttattt attgcaattt ttattggtgt ctttaccctg
    15541 gttcttctta caattaatct tttactaaag cgaaatgtca tcgatcctct caaaccaatg
    15601 gcgcaactgg ctcagaaaat tagcacaaat acatttgttt acagtcaagc tgaagaattt
    15661 gaattcaaaa atttagttgc gatcgctaag cgcactgatg agttaggtca tctagggcgt
    15721 atcttcctga gaatggtttg tgaagtctac gatcgcgagc aacgcatgaa acaacaaatg
    15781 cgcgaactta gtattagaat taacgaaact aagaaggctc gtgaagtgtc tgaaattgta
    15841 gaagctgact acttccagaa tttaagcgca caagcaaaag ctattagaaa taactgggca
    15901 aattctgatg aatagaagaa tcaacgctcc aaggaaaaac taatattctt cctttctttt
    15961 cagaaactat taaatatttg gaaatacatc atgtctaaaa ttgtgtcaat ccattcattc
    16021 cgtggtggaa caggcaaatc aaacgtaact gctaacctag caactattat ggctcgttcc
    16081 ggtaaacgga ttggtattgt ggatactgat attcagtcgc ctggaatcca cgtgcttttc
    16141 ggtctgaatg aggaaaagat aggctacact ctaaatgatt atctgtgggg gcgctgtgct
    16201 attgaaaatg ctgcctacga tgttacgcaa attcttaatc taagtcacaa aggtgctgcg
    16261 atcgggggta gtattcatct gattccctct agcattaaaa ctggggaaat atctcgaata
    16321 ctgcgtgaag gatacgacgc acgcctgctt aatgacagct tccgcaatct cagtcgccgc
    16381 ttgaaactag attacctgtt tattgatact caccctggta ttaacgaaga aaccctgctt
    16441 tctattatca tttctcatgt cttagttatc atcctgcgtc cagaccacca agactaccag
    16501 ggtactgctg tcactgtaga tgttgctcgc aagttagagg tgcctaaaat gctgttagta
    16561 gtgaataagg cactgccatc tctcaacttt caagcgatag cacaacaaat gcaaaaaagt
    16621 tacaacacaa ctgtagctag catcttacca gtttctgaag aaatgtttca attaggcagt
    16681 cgtgatgttt tttgcttgcg ctatcccaac catccttgga ctcaaggtgt aagtgcgatc
    16741 gcaaagcaaa ttctctttga ggataataag agttcgatga acttcaaaac tccactcagt
    16801 tggttcaacg gacgaagata agactgcggt tttattctgt taattgcaaa ctgtcagggc
    16861 gaggggactt acaaagaaag gcaaagggaa ggaggcagaa tacctccttc cctctgaaat
    16921 aaaaatgcgc gttgtgggag tagcgcccac taaaaaaaga tgtttttccg agatgcgtag
    16981 gacaagaaaa aacagcgtcc ttgtttcaat cccctgtctt tacccctacg gtggtgtaca
    17041 gatctctaca aaagagatga aacatcgtga aaagggagaa ttggaatgaa gttcccccct
    17101 tttttaaggg gggttagggg ggatcgaaac cgcaatgaat gcactatata agacttgtgt
    17161 acaccacctt aggtctttag gcaggggttc ttctaccctc tgccctcgta cttcaggcct
    17221 ctgaaaatac ttccttccgc ttccacaact gacagatcga cttcccaagt gcaaaaataa
    17281 ataagtttgt ttgtagtata atatacaaac tctaccttca ccagaaagca gagcaaggtt
    17341 tttcaataca atcacagcat ttgccgcgcc ataagctggg aaaacagccc ctgttgatgt
    17401 gccagttcct cgaaactacc gtgttgcaca actctaccgc tctggagtac ataaatccgg
    17461 ttagcgttac ggatcgtgct gaatcggtga gcgatcgcaa ttcgagtcac ttgcagccgc
    17521 tctaaacttt gactgacaat agcttgcgtt ctgttatcta aagcactagt cgcttcgtca
    17581 aatagcaaaa tccggggttt caacaccagt gcgcgagcaa ttaacagccg ttgtctttgc
    17641 cctccagaga ggttagaacc tccttcactg actacagtat gcatacccat tggcatagct
    17701 tcgatatcat ccgccaaacc agaggctcgg gctgcttccc acgcttcatc catcgtcact
    17761 agcgcaccac tagcaatatt ctcaaagata gaacctgaca tcattcggct attttgtatg
    17821 accacaccta actgtcggcg tactgcattg acatccaacc cagccaaatc ttgtccgtcg
    17881 tagtaaatgg ttcctgattc tggaaagtca aatcccagca gtaaccggaa caaagtagat
    17941 ttaccgcttc cagaaggtcc cacaatcgca atatactctc ctggctcagc tcgaatactc
    18001 acatcatcta atgtgagggg tccatcattt ccatagcgga aaaccacatg gtctacaacc
    18061 actctacctg ataatctacc aggatcggtt ttgctagaat ttaattccgg tgtcgctgaa
    18121 agaattggct gtgctcgatt ccacaaaggt aagacttcta aaacatccac aaccgtactg
    18181 ctgagactgg ttgctccact aataaaagtg gcataagcag agttaaatgc caaaaaagta
    18241 ccagtagaca aggctcctgc attcagttgt tgtccggatg ttgtatttaa tgtctggaca
    18301 gcaaaccaaa aaaggatggc atttgttaaa ggtggtagca ccttattggt gacggtaaga
    18361 aagtcttcta tcccctgcgt acttagcatg agttttagct gttggctgta ctgcttaccc
    18421 cagtaggcaa aagcccgtgc ttcagcccca gcgactcgga gtttagcaac tccatcgatc
    18481 aactgcacca tgacaccaga tatctcccct tctatctcta gcagggggcg aaccttatga
    18541 agggtgagaa tgccagaaac gacagtgacc ccaatattta caagagctac aacgcaggct
    18601 atcaaagcta atgaaacgtt atagtaaaac agcagcccca aattgagcaa tgaaaaaaga
    18661 ctggagaaaa tagtttttaa aacagtacta cttagtttct ctcggatttg agtgacagca
    18721 ttgacccgag agttcaaatc accaatagag tattgacgaa aaaaggaagc cctcagattc
    18781 aacagtcgat cccatacggc tgcttgggta gaggcatctg caaaagtttc taacctaata
    18841 atggcaaacc cttgagtgag ttgaaaaata ctttctccaa aggcagcagc tagcaaaccc
    18901 aaagcgattt gtatcaacac ttctcgctta gcatctggga ttgcattgtc aatcagaatg
    18961 gcagtagctg ttggggtcag cattcccagc aaggtcgttg caataccagt acacaaaata
    19021 acaatcaatt cccttgagtg accttgcaat gcaaacttaa gtaaatccca agttttgagt
    19081 tttttctcag ggagagggcg gtaaaatacg taggcattgg gaactagctt ggaagtagta
    19141 cgggcattta caggggtacg ggtctgcgct actggatcga aaatctcgta gcgattgtca
    19201 gataagggta acaaggcaac tgggtgattg tcttctatgg tgtaggttag cattggtccc
    19261 gagtccttct tccaccaccg atcggttaat gcaatccgac gcatcctgat ttgcgaggct
    19321 cgggcgatcg cttctaaggg gtcttgaatt cttgtaatat tttccgactt agcagggggg
    19381 cgaatcgtaa ctcccaaagc ccgtcccacg gcaccagcgg cgatgagtag agcttcgtcc
    19441 ggatcgctcg ttggtgtgac cgctgggtaa aagacggttt ttctctgttg cagtacggat
    19501 gaaagttctc ctaatgtctc tttcatcacc tgataattga gacgttctct ttcctggaat
    19561 ctacgcaatt ctgctgaaat ttcctgctgc tccaacagct gaatgtagtc gaggaaataa
    19621 gttgctagca aagttaaact gtctgctaag gtatctgcat cttgaattgc agagatatcc
    19681 tcactggata gctcgacttc atctgtagcc tgcaaccaca tctttgagtc taagggcaat
    19741 attccggata aaggcaaaag tggcagttcc tcaaacccca tccagttgac acacccttgc
    19801 tggatttgca cccaagttac agtgtcatgc tgaggctgga aaatatcgcc actccctaaa
    19861 gaaaagtagt ttatgccttc aggttgcact ggcattgtgg gtgcagtaac gtcggatagt
    19921 aaagagctga atcgatgaat ccaattctct accaaagcaa ttgcttggcg atcgccttta
    19981 acaatccatt tgctaaaatc ttctactggc actctaatga gttctgtctc ctccatcgac
    20041 accgcgagaa tttggcacac ctcgtcttga gaacttggtg tagttgagaa cattgcctcc
    20101 gacgcttcta cgttgaataa ataacgacga gaaccttctg caataccgtg tttgacttta
    20161 atgctaaaaa gtgctaaaga accagatttt acaacccaaa ctgtctcgcg atcgtctagc
    20221 aggattggtt cattaccttt aataatatat tgctgctgcg ctattccaaa cttaatttgc
    20281 tcgaccatga atcgctttgc tccaattcaa attaaaaatt tcttttttaa cttttaaata
    20341 ccaattcact ttctccccaa acccccagac tcaatctaaa gtgcttcccc ttcactgcga
    20401 attaattgca agtaggcacc ctcgatattc tttaattctt catgagttcc tctttgaacg
    20461 acctttcccc gctccaagac aataatttca tcacaatccc ggatggtact taatcgatgc
    20521 gccacaataa tacaagtaca acctcgctgg cggagtttgc ggtcaataat tttttccgtc
    20581 tcggtatcaa gggcgctagt agcttcatcc atcactaaga tggtggggtt atttactaaa
    20641 gctcgggcta tttccaaacg ctgtcgctgt cctccactca agttgctagc accttctagg
    20701 agatgggtac tgtaacctct tggcattgag agcacaacat catgaatcgc tgcgtcttga
    20761 caagcccgca taatgtaatt gtcaggtaca gtggtatccc atagagttaa attgtcccta
    20821 acactgcctg caaacagaaa aatatcctgc tccaccaaag caatcgaatt tgcaagtact
    20881 tggcgaggaa tttgccctct gagtttacca tcgaagcaaa tgtcaccttc ccaaggttca
    20941 tagagcccac atactagttt ggcaattgta gacttgccag aaccgcttcc ccccaccaaa
    21001 gcaactcgct gtcccggttt gagcgaaaga ttaaagtttt caatcaaggg aggagcaaca
    21061 cggttatacc caaaagtaat attctttaac tcgacatatc cctgtaattt ggcatgagat
    21121 agagaaggtg gaagagaaag taaaccatca ttttctccct gctcccttgc tttcttaccc
    21181 cctttcctct tatccttttc cccttgttcc aattgcgaat ctatagggtt gcgtaaaaca
    21241 tcatctaaac gattcaaatc gccttctact tcttggaggt tacttccaag agtcacaagc
    21301 tcgttaacag gttgtaaaaa tgcttgcatt aaactctgaa aagccactag cattccaatg
    21361 cttaaatatc catctatcac ccggaaaccg cccacaacca aaagcagcat ggaggaaagt
    21421 gtggaaagaa aagacggtag cactcctaaa gtttggtttg ttacatccat ttcctgcttg
    21481 gcattaattg acttagcata atagccagcc catcgggaaa agaaatctga ctccaaaccg
    21541 gatgctttta gtgtttccat actctgaaga ccagaaatcg aaactccagc tacttttcct
    21601 tcatcctgtt gcaatctcat atttgcatct acgcgccatc tcctcaccca ttgcaatgca
    21661 agaagattga cagcgacaaa ggcgattcca atcgaggtta agacagtgtc atactgcagc
    21721 atgacagctg cgtaaaaaac aactgtcact gctgcgatcg ctgtagtcgc taacttacct
    21781 gagagaatgt cagctaactt atcgttcagt tggacgcgat tgctaatttc cccagcaaag
    21841 cgttggtcgt aaaaactgac aggtagacgc aaaatatgcc ataggaactg actggacatc
    21901 cccacagata gcttaatttt catgtgacgc agggattgca actgtagtag agttaaaaat
    21961 cccatcagcc ccgctacaag aacgatcccc aaaatgagcg gtcgcaacca gtcgtttcta
    22021 ccctcaatca aaacattgtc tataaaaacc tgagagaatg ttggtattgc caatccggga
    22081 attacaagca gaaatcctgc gaacacggag taggctagcg cccctccaga cttttgcagc
    22141 ctttgccata gagccaggag tgtattgggt ttgcgacctc cttttttaaa ccccggaccg
    22201 ggctcgagaa ccaacacaac accagtatag gcatcactga attcttgtaa agaaacagta
    22261 cgcactccag atgcggggtc gttaagataa actcgttccc taccaaatcc ttctaccacc
    22321 aaataatggt tgaagttcca aaatacaata tagggacatt ccagttcttg caaggcttcc
    22381 aaatctattt taaaaccttt tgccttcaga ccataacttc tagcagcatt aagaatatta
    22441 gaagctttgc ttccgtctcg cgagactccg cagtcttgac gaagtcttga aagtgcgaca
    22501 attcgaccat aataacctaa aataatacct aaggcagcag caccgcattc cactgcctcc
    22561 atttgcaaaa gagtcggtgt acgacgccgg atgcgcttgc gccaaaaaaa taaatttcgt
    22621 agaaacatag attattggat accgctccag gatctaagga tgggaaagac aaaggtgatg
    22681 ggcgcttgtt cctccacagt cactcgtaca gaggtagtaa ttccaggaga cattttcatc
    22741 tgcggacctt tagaagaaga ccacttgtag tgactgaagg tggaagtgtc tggttgaagt
    22801 tcggctatga cttggaggtg aggaccctga gtcattaaac tttctacgat ttcggggttg
    22861 cctatcatat tagaggcacc ctctttagta ataggaaaag aagatacttt cttaacagtg
    22921 cccacaattc cgccaaagcg ttctcgctta actgtagagg gtgtaatttg caatgtcata
    22981 cccttttgaa tcttcttgcc ttcgctcact ggaaaaaatg caacgctcgc tagtttagca
    23041 gatggctctt gcgcttctat tgacccaata cgagttcctt gactgagaat ttgtccggga
    23101 gttatggtaa gttccaaaat gcgtccggta tattcgctct ttatatggct attgttattt
    23161 aattgcaatt ctatttgagt aatattccgt tttaattctt gaatttgatt ttgtcgggta
    23221 attgcggatt gaaaattttg ctcagccaga attttttcct tactatctag ttcttttaac
    23281 tgggtttt
//
