LOCUS       NZ_KL573572            10399 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces baarnensis strain NRRL B-2842 P144_Doro1_scaffold35,
            whole genome shotgun sequence.
ACCESSION   NZ_KL573572
VERSION     NZ_KL573572.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces baarnensis
  ORGANISM  Streptomyces baarnensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 101851)
  AUTHORS   Doroghazi,J.R., Albright,J.C., Goering,A.W., Ju,K.-S., Haines,R.R.,
            Tchalukov,K.A., Labeda,D.P., Kelleher,N.L. and Metcalf,W.W.
  TITLE     A Roadmap for Natural Product Discovery Based on Large-Scale
            Genomics and Metabolomics
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 101851)
  AUTHORS   Doroghazi,J.R., Ju,K.-S. and Metcalf,W.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-APR-2014) Institute for Genomic Biology, University of
            Illinois at Urbana-Champaign, 3109 IGB, MC-195, Urbana, IL 61801,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: IDBA UD v. 1.0.9
            Genome Coverage                   :: 74x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 02:19:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,395
            CDSs (total)                      :: 7,345
            Genes (coding)                    :: 7,173
            CDSs (with protein)               :: 7,173
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 172
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 55 of 173
            Pseudo Genes (incomplete)         :: 138 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 27 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 69480
            Orig. end                         :: 79879
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KL573572.1.
            Bacteria available from NRRL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(340..1440)
                     /locus_tag="BG84_RS0134885"
     CDS             complement(340..1440)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960017.1"
                     /locus_tag="BG84_RS0134885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_030088669.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 6.8e-20, bitscore:
                     64.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDQEEQRVLRVKGRVLVGPDEVRDELWAVDGRITYERPPGADRA
                     VTVTGWALPGLVDAHCHVGLDAHGPVDAATAEKQALADREAGTLLIRDAGSPSDTRWVD
                     DREDLPKIIRAGRHIARTRRYIRNYAHEIEPGDLVAYVAREARRGDGWVKLVGDWIDRD
                     AGDLTACWPRGELAAAIAEAHRLGARVTAHCFAEESLTDLVEAGIDCIEHATGLTEETI
                     PLFAERGVAIVPTLVNIATFPDLAAGGEAKFPRWSAHMRQLYERRYDTVRAAYDAGIPV
                     YVGTDAGGSLAHGLVAGEVAELVRAGIPPLEALSATAWGARRWLGRPVLEEGAPADLVV
                     YDEDPRADVRVLAAPRHIVLNGRVIG"
     gene            1529..2635
                     /locus_tag="BG84_RS0134890"
     CDS             1529..2635
                     /NRPS_PKS="Domain: Aminotran_5 (16-286). E-value: 6.8e-28.
                     Score: 89.5. Matches aSDomain:
                     nrpspksdomains_BG84_RS0134890_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123620.1"
                     /locus_tag="BG84_RS0134890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_030088671.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-23, bitscore:
                     75.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLPPLTADRFAAIERSVARLLATEQDVVITQGEALLPLE
                     GCIRSGARPGSTALNVVTGPYGQTFGNWLRDCGAQVVDLAVPFHTAVTAGQVAEALAAH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVGAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSARAWERMAANPAAPRRSYLSLLDWKERWIDGGRKALPHAP
                     AQLEMLGLEACVARIEDTGLDMVMARHASAAAATRAGAVALGGGLEPYVHAARDAAPVA
                     TTLRAPAGTDAAALVAHALAADPSLPLVAGGGALSKEMIRVNHYGADATRDAVLSSLAA
                     LGSALTDAGLRVDIDAARAAVSETWPGR"
     aSDomain        1577..2386
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BG84_RS0134890_Aminotran_5.1"
                     /evalue="6.80E-28"
                     /label="BG84_RS0134890_Aminotran_5.1"
                     /locus_tag="BG84_RS0134890"
                     /protein_end="286"
                     /protein_start="16"
                     /score="89.5"
                     /tool="antismash"
                     /translation="AAIERSVARLLATEQDVVITQGEALLPLEGCIRSGARPGSTALNV
                     VTGPYGQTFGNWLRDCGAQVVDLAVPFHTAVTAGQVAEALAAHPEIDFVSLVHAEAATG
                     NTNPVAEIGEVVRAHGALFMLDAVASVGAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAV
                     SVSARAWERMAANPAAPRRSYLSLLDWKERWIDGGRKALPHAPAQLEMLGLEACVARIE
                     DTGLDMVMARHASAAAATRAGAVALGGGLEPYVHAARDAAPVATTLRA"
     misc_feature    complement(2728..2742)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.79"
                     /tool="antismash"
     misc_feature    complement(2751..2768)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.5"
                     /tool="antismash"
     misc_feature    2760..2777
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    complement(2762..2777)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2772..2787
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2906..2918
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(2918..2932)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     gene            2943..3473
                     /gene="ectA"
                     /locus_tag="BG84_RS0134895"
     CDS             2943..3473
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607778.1"
                     /locus_tag="BG84_RS0134895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_078611306.1"
                     /transl_table=11
                     /translation="MTAAPADFARARSEFLSIDTPRVEDGAAIWRIARDSQVLDLNSSY
                     SYLLWCRDFAATSVVARGENGEPIAFVTGYIRPDRPRTLVVWQVAVDQAHRGKGLAATL
                     LDALTARVAADQGLSSVETTITPDNTASDRLFTSYAQRHDVALEQEVLFDGALFPEGTH
                     LPEVLYRIGPFAA"
     gene            3649..4911
                     /gene="ectB"
                     /locus_tag="BG84_RS0134900"
     CDS             3649..4911
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-363). E-value: 4.7e-72.
                     Score: 234.8. Matches aSDomain:
                     nrpspksdomains_BG84_RS0134900_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="BG84_RS0134900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_030088675.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.1e-78, bitscore:
                     257.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGARLTDEDGHTY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLETFQNVILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARA
                     EWLRALKELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALDAYWADGQMEKQTLARGEQVEQTLL
                     AICAEEPTAQFRGRGLVWGMEFEDPARASAVCARAFELGLLLETSGPQSEVVKLLPPLT
                     VTPEELDEGLRTLARCVRETA"
     aSDomain        3733..4737
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BG84_RS0134900_Aminotran_3.1"
                     /evalue="4.70E-72"
                     /label="BG84_RS0134900_Aminotran_3.1"
                     /locus_tag="BG84_RS0134900"
                     /protein_end="363"
                     /protein_start="28"
                     /score="234.8"
                     /tool="antismash"
                     /translation="FDRAQGARLTDEDGHTYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMATTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALKELCERQDMLLIVDDIQMGCGR
                     TGGFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALDAYWADGQMEKQTLARGEQVEQTLLAICAEEPTAQFRGRGLVWGMEFE"
     gene            5001..5399
                     /locus_tag="BG84_RS0134905"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123624.1"
                     /locus_tag="BG84_RS0134905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_006123624.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.8e-55, bitscore:
                     178.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFSDIENTDRHVKAASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCTEGEAELTNDETGEKHWITPGTMYLLDGHERHTMRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEG"
     gene            5403..6296
                     /gene="thpD"
                     /locus_tag="BG84_RS0134910"
     CDS             5403..6296
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156966.1"
                     /locus_tag="BG84_RS0134910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_030088678.1"
                     /sec_met_domain="PhyH (E-value: 1.5e-40, bitscore: 132.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPIVAKDLQSY
                     EHDGFLSIEQLITPDEVAVYQAELDRLISDPAIRADERSIVEKQTQNVRSVFEVHRISE
                     VFAGLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNM
                     RTVSVSIALTENFDTNGGLMIMPGSHKSFLGCAGETPKDNYKKSLQMQDAGTPSDEALT
                     KMADRHGIRLFTGKAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENAAEEPFAAP
                     IRRPEFIGARDFTPVK"
     gene            6396..7430
                     /locus_tag="BG84_RS0134915"
     CDS             6396..7430
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070337.1"
                     /locus_tag="BG84_RS0134915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_030088680.1"
                     /transl_table=11
                     /translation="MSSHVRHITIDCSDAYGLGAFWAQVLDAPLSDEDSPGDPEALVEA
                     PGAAILFVRVEDPKQTKNRVHLDIQPQDRSRDEEVERLLALGATLVGDHRRPNGRGWVT
                     LADPEGNEFCVECSAAERAALTGTRLPVTADDVTSAVRLAVDALAGAPADRWDTPAGSL
                     TWTCWETVEHLSDDLFAYAAQLGPRTPPLDHDVPYRWAPDREGGPHNAVFADRTAGTAG
                     LLATLEASGALLASMARTTPPGVRSYHGYGISDPEGFAAMGVVETLVHTYDLAEGLGLE
                     WSPSPALCDRVLARLFPDAPAGGDRWTVLLWATGRAELPGHPRRTSWRWDGRPLEDQTA
                     SSAG"
     gene            complement(7406..8476)
                     /locus_tag="BG84_RS0134920"
     CDS             complement(7406..8476)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969934.1"
                     /locus_tag="BG84_RS0134920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkene reductase"
                     /protein_id="WP_030088682.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLSGTPLANRIALAPMTRSRAGEGGTATELTATYYAQ
                     RASAGLVITEGIQPSAVGQGYPSTPGLHSAEQVASWRTVTDAVHAKGGRIFAQIMHAGR
                     IGHPVLLPDGLVPVSASPVRAEGQVYTHVGPKDFVEPHELTDAEVRATVADFVTAARNA
                     VEAGFDGVELHGANGYLIHQFLAPNTNLRTDAWGGSDEARTRFAVEVVKAVAAEIGPER
                     TALRISPGNPYNDIDEPAPEATYTALVREIEPLGLAYLHILEAVPIRELTLALRKAFSG
                     TVVINVHSDGPTGPGDHTVIDDGIADLISYGALFLANPDLPARLKAGGPFNTPDPSTFF
                     GGDAQGYTDYPALDAV"
     gene            8672..9178
                     /locus_tag="BG84_RS0134925"
     CDS             8672..9178
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957688.1"
                     /locus_tag="BG84_RS0134925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_030088684.1"
                     /transl_table=11
                     /translation="MTTGHAAPAEESCTDALPTAAIGGPVSHAVSRVARLHRIAAGKAL
                     KGVELYPGQELLMMHLWDRGAVRQTELIRSLELDPSTVTKMLQRLEQTGHVRRRPDPAD
                     RRAVLVEATDESCALHTAVEAAWGSLEEHTLAGLDPAERAELARLLAKVEENLCRETAD
                     CPDRR"
     gene            complement(9210..10268)
                     /locus_tag="BG84_RS0134930"
     CDS             complement(9210..10268)
                     /NRPS_PKS="Domain: Aminotran_5 (19-347). E-value: 9.1e-23.
                     Score: 72.7. Matches aSDomain:
                     nrpspksdomains_BG84_RS0134930_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012381431.1"
                     /locus_tag="BG84_RS0134930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_030088685.1"
                     /sec_met_domain="Aminotran_5 (E-value: 3.1e-17, bitscore:
                     55.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILAPIQAAAVEFAPEVTYLNTSSWGLLPRRTIAAVKDLADENA
                     VGRREGAGSFDAVEAARVGFARLAGVHPDRVATGCSVTVHVGLIAASLPAGAEVLCPEG
                     EFASVVSPFALRGDLRVRYAPLADLAGAVRPSTDLVAFSAVQSADGRVADLAAVRAAAA
                     AHGARTLLDATQAAGWFPLDAGAYDYTVTGGFKFLLCPRGTSFLTVTEEAQDTLPPLFA
                     GWVSAGAPWASNYGPLERLAPTARGFDEPPAFLSYHGAEHSLALLAEVGPDALYAHATG
                     LAARLRAGLAGLGREVVPGESAIVSVPGLQGRRDDLMKAGIAVSAPAGNLRISCHLYNT
                     EADVDRVLEFLA"
     aSDomain        complement(9228..10211)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BG84_RS0134930_Aminotran_5.1"
                     /evalue="9.10E-23"
                     /label="BG84_RS0134930_Aminotran_5.1"
                     /locus_tag="BG84_RS0134930"
                     /protein_end="347"
                     /protein_start="19"
                     /score="72.7"
                     /tool="antismash"
                     /translation="YLNTSSWGLLPRRTIAAVKDLADENAVGRREGAGSFDAVEAARVG
                     FARLAGVHPDRVATGCSVTVHVGLIAASLPAGAEVLCPEGEFASVVSPFALRGDLRVRY
                     APLADLAGAVRPSTDLVAFSAVQSADGRVADLAAVRAAAAAHGARTLLDATQAAGWFPL
                     DAGAYDYTVTGGFKFLLCPRGTSFLTVTEEAQDTLPPLFAGWVSAGAPWASNYGPLERL
                     APTARGFDEPPAFLSYHGAEHSLALLAEVGPDALYAHATGLAARLRAGLAGLGREVVPG
                     ESAIVSVPGLQGRRDDLMKAGIAVSAPAGNLRISCHLYNTEADVDRV"
ORIGIN
        1 tggaaccccc acaagagaca tggagccacc ggcacggtcc aatgggggac atcgcccgtg
       61 ccggcggcct cgactccgtg aatctttacg cactgagggt gaactggcgg atacctggcg
      121 tgagttcacc ccaaaggggg gtttccgcgc gcatattcga atctttcggc acgcgcgttc
      181 cccggtgtca ctcgtttcac ccggctccgg tcgtacggca cccgaacaca ccggacgaca
      241 ccacgcggta cacagaggtg cttcaacgag ccggggccgt ctccgtcact gcccgtcaac
      301 acagcaccgc gccgcccccg acacggcacc gcaccgccgt cagccgatca cgcgcccgtt
      361 cagcacgatg tgccgaggag ccgccagcac ccgcacgtcc gcgcgcggat cctcgtcgta
      421 cacgaccagg tcagccgggg cgccctcctc cagcaccggc cgccccagcc agcgcctggc
      481 tccccacgcg gtggcggaga gggcctccag cggcgggatg cccgccctga ccagctcggc
      541 gacctcgccc gcgaccaggc cgtgcgccag cgagccgccc gcgtcggtgc cgacgtagac
      601 cgggatgccc gcgtcgtacg ccgcgcgcac ggtgtcgtag cggcgttcgt acagctgccg
      661 catatgggcg gaccagcggg ggaacttggc ctcgccgccc gccgcgaggt ccgggaaggt
      721 ggcgatgttg accagcgtcg ggacgatcgc gaccccgcgt tcggcgaaga gcgggatggt
      781 ctcctcggtg aggccggtgg catgctcgat gcagtcgatg cccgcctcga ccaggtcggt
      841 gagcgactcc tcggcgaagc agtgcgcggt gacccgggcg ccgagccggt gcgcctcggc
      901 gatggccgcc gccagctcgc cgcgcggcca gcaggcggtc aggtccccgg cgtcgcggtc
      961 gatccagtcc cccaccagct tgacccagcc gtccccgcgc cgggcctccc gggccacgta
     1021 cgcgacgagg tcgccgggct cgatctcatg ggcgtagtta cggatgtagc ggcgggtcct
     1081 ggcgatgtgc cggccggccc tgatgatctt cggcagatcc tcgcggtcgt cgacccaccg
     1141 ggtgtcggag ggcgatccgg cgtcccggat cagcagcgtt ccggcctccc ggtcggcgag
     1201 cgcctgcttc tcggcggtgg ccgcgtcgac cgggccgtgc gcgtccaggc ccacatggca
     1261 gtgcgcgtcg accagaccgg gcagcgccca gccggtgacg gtcaccgcgc ggtccgcgcc
     1321 gggcggccgc tcgtaggtga tccgcccgtc cacggcccac agttcgtccc gcacctcgtc
     1381 cgggccgacg agcacccggc ccttcacccg cagcacccgc tgttcctcct gatcactcat
     1441 aggcggcact gtacgaggcc gccggagggc cgtcggtagg ctgccggtgt ctttccgacc
     1501 gccgcacgca cccgaagaga gccccaccgt gacgcacccc ttcctcgacc tcccgccgct
     1561 caccgccgac cgcttcgcgg cgatcgaacg gtccgtggcc cggctcctcg ccacggagca
     1621 ggacgtcgtc atcacccagg gcgaggcgct gctgccgctg gagggctgta tccgcagcgg
     1681 cgcgcggccc ggctcgaccg cgctgaacgt ggtcaccggc ccctacgggc agaccttcgg
     1741 caactggctg cgggactgcg gcgcgcaggt cgtcgacctc gcggtgccct tccacacggc
     1801 ggtgacggcc ggccaggtcg ccgaggcgct cgccgcgcac ccggagatcg acttcgtctc
     1861 gctggtgcac gcggaggcgg cgaccggcaa caccaatccg gtcgcggaga tcggcgaggt
     1921 ggtccgggcg cacggcgcgc tgttcatgct ggacgcggtc gcctcggtgg gcgccgagcc
     1981 gctgctgccg gacgcctggg gcgtcgacct gtgcgtgatc ggcgcgcaga aggccatggg
     2041 cgggccggcc ggggtctccg cggtgtcggt gagcgcgcgg gcctgggagc ggatggccgc
     2101 caacccggcc gccccgcgcc gctcctacct ctccctcctg gactggaagg agcgctggat
     2161 cgacgggggc cgcaaggcgc tgccgcacgc cccggcgcag ctggagatgc tgggcctgga
     2221 ggcctgtgtg gcgcggatcg aggacacggg cctggacatg gtgatggccc gccacgcctc
     2281 ggcggccgcg gcgacccggg cgggtgcggt ggcactgggc ggcggtctgg agccgtacgt
     2341 ccacgccgcg cgggacgccg ctccggtggc cacgacgctg cgcgccccgg cggggaccga
     2401 cgccgccgcg ctggtcgcgc acgcgctggc ggccgatccc tcgctcccgc tcgtcgcggg
     2461 cggcggggcg ctgtccaagg agatgatccg ggtcaatcac tacggggcgg atgcgacgcg
     2521 ggacgcggtg ctgtcctcgc tcgcggctct ggggtcggcg ctgaccgatg cgggcctgcg
     2581 ggtcgatatc gatgctgccc gggccgccgt ttcggaaacc tggccgggcc gctgatattc
     2641 ataatgcggg gagctgcttt atcgaaagca gctccccgca ttcttctgcc cgctttcccg
     2701 gtacctaaac gcggaagttt ttcgggcatc gaacttcgtg attcggacac gtctcaggag
     2761 agttacaacc ctgtgaccga ctccacatcg gcggcgttat gcccgaaaaa ttcgggacaa
     2821 agagcctgaa aaaccacccg gatcatggcg gatctcgcgc acgcctgata acacacgaag
     2881 gcgcttcacc caacccttca cgtcgatgca atttcgaaat ttgctgggta aattcaattc
     2941 ccatgaccgc cgcaccagca gattttgccc gtgcccgaag cgaattcctc agtatcgaca
     3001 ccccacgagt ggaggacgga gccgcgatct ggcgcatcgc ccgcgactcc caggtcctgg
     3061 acctgaactc ctcgtacagc tacctgctgt ggtgtcgtga cttcgccgcg acctccgtcg
     3121 tcgcccgtgg cgagaacggc gagcccatcg ccttcgtgac gggctacatc cggcccgacc
     3181 gcccccggac cctcgtcgtc tggcaggtgg ccgtggacca ggcccaccgc ggcaaggggc
     3241 tggccgccac tctgctggac gcgctgaccg cccgggtagc cgccgaccag ggcctgtcgt
     3301 ccgtggagac gacgatcacc ccggacaaca ccgcatccga ccggctgttc acgtcctacg
     3361 cccagcgcca cgacgtcgcg ctggagcagg aggtgctctt cgacggcgcg ctgttccccg
     3421 aagggacgca tctgcccgag gtgctctacc ggataggccc gttcgccgcc tgaccggccc
     3481 gttcgcctgc cgaacccgcc cggccgccac cccggcgtac ccgacccgta cgcccggcct
     3541 cccagacttt tcgcgccggc cgaccacccg gcgcggtccc ggccgcctcc gtgcggcggg
     3601 gagcattcga ccaccgcccg tcacaccccc tcacgcagga gatccgctgt gaccatcacc
     3661 ccgcccgcac tgagcgtctt cgagaccctt gagtccgagg tccgcagcta ctgccgcggc
     3721 tggcccgccg tgttcgaccg tgcccagggc gcccggctga ccgacgagga cggccacacc
     3781 tacctggact tcttcgccgg ggccggttcg ctgaactacg gccacaacaa cccggtgctg
     3841 aaacgagcgc tgatcgacta catcgagcgc gacggcatca cccacggtct cgacatggcg
     3901 accaccgcca agcgcgcgtt cctggagacg ttccagaacg tgatcctgcg gccgcgcgac
     3961 ctgccgtaca aggtgatgtt ccccggcccg accggcacca acgccgtcga gtcggcgctg
     4021 aagctggccc gtaaggtcaa gggccgcgag tccgtcgtct cgttcaccaa cgccttccac
     4081 ggcatgtcgc tgggctcgct ggccgtcacc ggcaacgcgt tcaagcgggc cggcgccggg
     4141 atcccgctgg tgcacggcac cccgatgccg ttcgacaact acttcgacgg tacggtcccc
     4201 gacttcctgt ggttcgagcg actgctggag gaccagggct ccgggctgaa caagcccgcc
     4261 gccgtgatcg tggagacggt ccagggcgag ggcggcatca acgtggcccg cgccgagtgg
     4321 ctgcgcgcgc tcaaggaact gtgcgagcgc caggacatgc tgctgatcgt cgacgacatc
     4381 cagatgggct gcggccgtac cggcggcttc ttctcgttcg aggaggccgg catcgtcccg
     4441 gacatcgtca cgctgtcgaa gtccatcagc ggctacggac tgccgatgtc gctctgcctg
     4501 ttcaagccgg agctggacat ctgggagccg ggcgagcaca acggcacctt ccgcggcaac
     4561 aacccggcct tcgtcacggc cgccgccgcg ctggacgcct actgggcgga cggccagatg
     4621 gagaagcaga ccctggcccg cggcgagcag gtcgagcaga cgctgctggc catctgcgcc
     4681 gaggagccga ccgcgcagtt ccgcggccgg ggcctggtgt ggggcatgga gttcgaggac
     4741 ccggcgcgcg cctcggcggt ctgcgcccgc gccttcgagc tggggctcct gctggagacc
     4801 tcgggcccgc agagcgaggt cgtcaagctg ctgccgccgc tgaccgtcac ccccgaggaa
     4861 ctggacgagg gcctgcgcac gctggcccgc tgcgtccgcg agacggcctg acccggaacg
     4921 gccggggcag gcgcagaaga agaggtcccg ggccgtgagg cccggggccc gtgcagagaa
     4981 gagaaaggca accgctcacc gtgatcgtcc gatcgttcag tgacatcgag aacaccgacc
     5041 ggcatgtgaa ggccgcgtcc ggcacctggg agagcaagcg catcgtgctc gccaaggaga
     5101 aggtgggctt ctcgctccac gagaccgtgc tgtacgcggg cacggagacc tccatgtggt
     5161 acgcgaacca catcgaggcg gtgctgtgca ccgagggcga ggccgagctc accaacgacg
     5221 agaccggcga gaagcactgg atcacgcccg gcacgatgta tctgctggac ggacatgagc
     5281 ggcacaccat gcggcccaag accgacttcc gctgcgtgtg cgtcttcaat ccccccgtca
     5341 ccggacggga ggaccatgac gagaacggtg tctacccact gctgaccgag gagggctgaa
     5401 ccatgaccac cgaagtacgc gccgatctgt acccctcgcg cggcgccgcc gagatgacca
     5461 ctccccgcca ggacccggtc atctggtccg cgccgggcgc accgggtccg atcgtcgcca
     5521 aggacctcca gagctacgag cacgacggct tcctcagcat cgagcagctg atcacgccgg
     5581 acgaggtcgc cgtctaccag gcggagctgg accggctgat ctccgacccg gcgatccgcg
     5641 ccgacgagcg ctccatcgtc gagaagcaga cgcagaacgt gcggtccgtc ttcgaggtcc
     5701 accggatcag tgaggtcttc gccgggctgg tccgtgacga gcgggtggtg ggccgggccc
     5761 gccagatcct cggctcggac gtgtacgtcc accagtcccg gatcaacgtg aagccgggct
     5821 tcggggcctc gggcttctac tggcactcgg acttcgagac ctggcacgcg gaggacggtc
     5881 tgccgaacat gcggacggtg tccgtgtcga tcgcgctgac cgagaacttc gacaccaacg
     5941 gcgggctgat gatcatgccc ggttcgcaca agtcgttcct cggctgtgcg ggcgagacgc
     6001 cgaaggacaa ctacaagaag tcgctccaga tgcaggacgc cggcaccccg tccgacgagg
     6061 cgctgacgaa gatggccgac cgccacggca tcaggctctt cacgggcaag gccggttcgg
     6121 cgacctggtt cgactgcaac gccatgcacg gctcgggcga caacatcacc ccgtacgcgc
     6181 gcagcaatgt cttcatcgtc ttcaacagcg tggagaacgc ggccgaggag cccttcgcgg
     6241 ctccgatccg ccgccccgag ttcatcgggg cgcgggactt cacgccggtg aagtagccga
     6301 cgcgccaggg agtcggggcc gggacggtac gccgtcccgg ccccgcctgc gtaactcgct
     6361 ggaccggggc cgggtcagcg gacagggtgt ccgccatgag ttcccacgta cgccacatca
     6421 cgatcgactg ttccgacgcc tacggactcg gcgccttctg ggcccaggtg ctcgacgccc
     6481 cgctctccga cgaggactcc cccggtgatc cggaggcgct ggtcgaggcg cccggcgcgg
     6541 cgatcctctt cgtccgggtg gaggatccga aacagaccaa gaaccgggtc catctggaca
     6601 tccagccgca ggaccgctcc cgggacgagg aggtagagcg gctgctcgcg ctcggggcca
     6661 cgctggtggg cgaccaccgc cgaccgaacg ggcggggctg ggtgacgctc gccgatcccg
     6721 agggcaacga gttctgtgtg gagtgctccg ccgccgagcg ggcggcgctg accggcaccc
     6781 ggctgccggt gacggccgac gatgtgacct cggcggtgcg gctcgcggtg gacgcgctgg
     6841 ccggtgcccc ggcggaccgc tgggacacgc ccgccggaag cctcacgtgg acctgctggg
     6901 agacggtgga gcacctgagc gacgatctgt tcgcgtacgc ggcgcagttg ggccctcgta
     6961 cgcctccgct ggaccacgat gtgccctacc ggtgggcgcc ggaccgggag ggcgggccgc
     7021 acaacgcggt cttcgccgac cggacggcgg gcaccgccgg gctgctggcc acgctggagg
     7081 cgagcggggc gctgctggcc tcgatggcgc ggacgacgcc gcccggggtg cgctcgtacc
     7141 atgggtacgg gatctccgac ccggagggct tcgccgcgat gggcgtggtg gagaccctgg
     7201 tgcacacgta cgacctcgcc gagggcctgg ggctggagtg gtcgccgtcc ccggcgctct
     7261 gcgaccgggt gctggcccgg ctcttccccg acgccccggc gggcggcgac cggtggaccg
     7321 tcctgctgtg ggccaccggc cgcgccgagc tgccgggcca cccgcgccgc acctcgtggc
     7381 ggtgggacgg gcggcccctg gaggatcaga cggcgtcgag cgccgggtag tcggtgtagc
     7441 cctgggcgtc gccgccgaag aaggtcgacg ggtcgggggt gttgaacggg ccgcccgcct
     7501 tcagccgggc gggcaggtcc gggttggcga ggaagagcgc cccgtaggag atcaggtcgg
     7561 cgatgccgtc gtcgatcacc gtgtggtcgc cgggtccggt ggggccgtcg gagtgcacgt
     7621 tgatgacgac ggtcccggag aaggccttgc gcagggcgag ggtcagctcg cggatcggga
     7681 cggcctccag gatgtgcaga taggcgaggc cgagcggctc gatctcccgg accagcgcgg
     7741 tgtacgtggc ctccggcgcg ggctcgtcga tgtcgttgta cgggttgccg ggcgagatgc
     7801 gcagtgcggt gcgctccggg ccgatctcgg cggcgacggc cttgacgacc tcgacggcga
     7861 agcgggtacg ggcctcgtcg gagccgcccc acgcgtcggt gcgcaggttg gtgttggggg
     7921 cgaggaactg gtggatgagg tagccgttgg cgccgtgcag ctcgaccccg tcgaatccgg
     7981 cctccacggc gttgcgggcg gcagtgacga agtcggcgac ggtcgcgcgg acctcggcgt
     8041 cggtcagctc gtgcggctcg acgaagtcct tcgggccgac gtgggtgtag acctgcccct
     8101 cggccctgac cggggaggcg ctgacgggga cgaggccgtc ggggagcagg accgggtggc
     8161 cgatgcggcc cgcgtgcatg atctgggcga agatcctgcc gcccttcgcg tgcaccgcgt
     8221 cggtgaccgt acgccaggag gcgacctgct cggcgctgtg cagcccgggc gtggaggggt
     8281 agccctggcc cacggcggac ggctggatgc cttcggtgat caccaggccg gccgaggcgc
     8341 gctgggcgta gtaggtggcg gtgagctcgg tggcggtgcc gccctcaccg gcccggctgc
     8401 gggtcatcgg ggccagggcg atgcggttgg ccagcggggt gccggacagg tcgatcgggt
     8461 cgaaagcggt ggtcatgaag gctcccagat aagtatgtgg tcggccaagc atcggcgccg
     8521 acggccacca tagcccattc attggccgac caaggtaaag tcgtgggaaa ccgtcgggcg
     8581 ttcagtccgg catccggtcg ggcatcatcg gaagccgcca ccgaaagccc ccgccagaga
     8641 ccgtccggcc cgaggacccc aggagcccgc catgaccacc ggccacgccg cccccgcgga
     8701 agagtcctgt accgacgcgc tgcccacggc ggcgatcggc gggccggtga gccacgccgt
     8761 ctcccgggtg gcccggctgc accggatcgc ggcgggcaag gcgctcaagg gggtggagct
     8821 ctatccgggg caggagttgc tgatgatgca cctgtgggac cggggggcgg tccgtcagac
     8881 ggagctgatc aggtcgctgg agctggaccc gtccacggtc acgaagatgc tccagcgact
     8941 ggagcagacc gggcatgtgc gccgccgccc cgacccggcc gaccggcggg ccgtactggt
     9001 cgaggcgacg gacgagagct gcgcgctgca caccgcggtc gaggccgcgt ggggcagcct
     9061 ggaggagcac acgctcgcgg gcctggaccc ggccgagcgc gcggagctgg cgcggctgct
     9121 ggcgaaggtc gaggagaacc tctgccggga gaccgcggac tgccccgacc ggcgctgagc
     9181 cgtacggccc ccggacgcac gcggagcggt caggccagga actccagcac ccggtccaca
     9241 tcggcctcgg tgttgtagag gtggcaggag atccgcagat tcccggccgg ggccgagacg
     9301 gcgatcccgg ccttcatcag atcgtcccga cggccctgca gccccggtac ggagacgatc
     9361 gccgactccc ctggcaccac ctcgcgcccg agcccggcca gcccggcgcg cagccgcgcc
     9421 gcgagcccgg tggcgtgcgc gtacagggcg tcggggccga cctccgcgag cagggcgagg
     9481 gagtgctccg ccccgtggta cgagaggaag gcgggcggct cgtcgaagcc gcgggcggtc
     9541 ggggcgaggc gctccagcgg gccgtagttg ctcgcccagg gcgcaccggc ggagacccag
     9601 ccggcgaaga gcggcggcag ggtgtcctgc gcctcctcgg tgaccgtcag gaacgacgta
     9661 ccgcgcgggc agagcaggaa cttgaagcca ccggtgacgg tgtagtcgta cgccccggcg
     9721 tccagcggga accagcccgc cgcctgggtg gcgtccagca gggtccgggc cccgtgcgcc
     9781 gcggcggccg cgcggacggc ggcgaggtcg gcgacccggc cgtcggccga ctgcaccgcg
     9841 gagaaggcga ccaggtcggt cgagggccgt acggccccgg cgaggtccgc gagcggcgcg
     9901 taccgtacgc gcagatcgcc gcggagcgcg aacgggctga ccacggaggc gaactcgccc
     9961 tcgggacaga ggacttcggc accggccggc agcgaagcgg cgatcaggcc gacgtgcacg
    10021 gtgacggaac agccggtggc gacccggtcg gggtggaccc cggcgagccg ggcgaatccg
    10081 acccgggcgg cctcgaccgc gtcgaagctg cccgccccct cccgccggcc gacggcgttc
    10141 tcgtcggcca ggtccttgac ggcggcgatc gtccgacggg gcagcagacc ccagctggag
    10201 gtgttgaggt aggtgacctc gggcgcgaat tcgacggctg cggcttggat gggcgcgagg
    10261 atcgtcatac gtccaccctg aagccccctc aacccaaagt caattactga gagttaaggg
    10321 gtgcacccaa ggattgctta tgtatcgctg gtgaaccgcg cccgccggag ctcagctccc
    10381 cgggacctcg caggccccg
//
