LOCUS       NZ_KL573546            11368 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces baarnensis strain NRRL B-2842 P144_Doro1_scaffold8,
            whole genome shotgun sequence.
ACCESSION   NZ_KL573546
VERSION     NZ_KL573546.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces baarnensis
  ORGANISM  Streptomyces baarnensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 217178)
  AUTHORS   Doroghazi,J.R., Albright,J.C., Goering,A.W., Ju,K.-S., Haines,R.R.,
            Tchalukov,K.A., Labeda,D.P., Kelleher,N.L. and Metcalf,W.W.
  TITLE     A Roadmap for Natural Product Discovery Based on Large-Scale
            Genomics and Metabolomics
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 217178)
  AUTHORS   Doroghazi,J.R., Ju,K.-S. and Metcalf,W.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-APR-2014) Institute for Genomic Biology, University of
            Illinois at Urbana-Champaign, 3109 IGB, MC-195, Urbana, IL 61801,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: IDBA UD v. 1.0.9
            Genome Coverage                   :: 74x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 02:19:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,395
            CDSs (total)                      :: 7,345
            Genes (coding)                    :: 7,173
            CDSs (with protein)               :: 7,173
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 172
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 55 of 173
            Pseudo Genes (incomplete)         :: 138 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 27 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 150147
            Orig. end                         :: 161515
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KL573546.1.
            Bacteria available from NRRL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(266..275)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            765..1682
                     /locus_tag="BG84_RS0116330"
     CDS             765..1682
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955796.1"
                     /locus_tag="BG84_RS0116330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_078611166.1"
                     /transl_table=11
                     /translation="MPEGLTEQVDTSPAKEPGPGVESRAESGAEPGPDVVRAEGLTFGY
                     PGRRVLSGVDLSIRAGELVALIGLNGCGKSTFLKLAAGLLTPSGGRVLLEGDDVARLPR
                     RTAARRVALLHQSAPTVPGLTVRQLVRQGRYAARGPLGMLREGDDEVTSRALADVGVTA
                     WADRPVDALSGGERQRVRLAMALAQDARVLFLDEPTTYLDLRHQLEVLQTVVRLRAERR
                     LTVVMVLHDLNHAARFADRIVALREGRVAADGPPAEVVTRQLLAEVLGVDGRVGIDSEG
                     GWPVCYPDHPLEPLQLLRNENHIH"
     gene            1771..1905
                     /gene="amiA"
                     /locus_tag="BG84_RS1000000140785"
     CDS             1771..1905
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="BG84_RS1000000140785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_240805756.1"
                     /transl_table=11
                     /translation="MENNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTAGEK"
     gene            2079..>2823
                     /locus_tag="BG84_RS0116340"
     CDS             2079..>2823
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452727.1"
                     /locus_tag="BG84_RS0116340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_030081847.1"
                     /transl_table=11
                     /translation="MTRSRLAPGTGIVTAPGAGPVLRTSGGEFLRIDTGGVDAGTLVRR
                     LVGEEAPEEGAHTAELTRLIAAFEEGGHAVAAPPRAPLAGRTVHVLGDPVLTVPVARCA
                     GAEGAEVHGTTPDRVAELAGATSDRSADGRVAVVWCLDSPVPEGFWDTADRLPGQGIAW
                     LRCHREGAHVWTEPLASAPGDVTARHVRLRRLAATAAHRELAAYWAGHRTPDTGPHPTE
                     ASAALIAGLLTADLIAWAEAEAEAEA"
     assembly_gap    2824..3075
                     /estimated_length=252
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     misc_feature    complement(3200..3214)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            3322..5004
                     /locus_tag="BG84_RS0116350"
     CDS             3322..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377868.1"
                     /locus_tag="BG84_RS0116350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_030081848.1"
                     /transl_table=11
                     /translation="MNTRTVYVPTPDGIALATDVCLPDGTRPRPAVVIRTPYGRDAHRA
                     ELRGWAAHGFAALAQDVRGRHGSPGEWHPYRGHEMADGTATVAWVRAQAWSSGEVVAVG
                     ASYAAHCALVTALVTADGALLGGAPDAVIAAVPALGLTETAREPGGPERLWARAGWWAA
                     HGDRRDSDPDALARALADDPRLLEHLPIARLADRLAEDLGRQLPSWPRLWADRSRGRIV
                     AQGSAARLPLLAVGGTRDPFAEDTVALWHAWGGPSRLLLGPWGHRLAADPAVPARARVN
                     LGALYVRWARAALAGQLEPTRHGVIALGDSGRWHSTRVRSAPRPPSPDGRPDRDRRTVA
                     TDAASRATAEAAVPVRVLPAAPAPFPDADPVRTVAWPFDSPTGLRLLHGAEFSADPDRP
                     VRSDDLAVPAGGDRADRCLLLSPPLPRPLDLVGAAVARINATADAPCADWAVRLTALDP
                     SGRADPLAFGIVRHTGPPGEAADITVPLGTLGRRLPAGTRLRAEIAGHHFPAHARNPHT
                     GEDPVTATRLVTSHRTVNPRGSALHLPVVARRRYVEPVPEICR"
     gene            5001..6368
                     /locus_tag="BG84_RS0116355"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="BG84_RS0116355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_030081850.1"
                     /sec_met_domain="YcaO (E-value: 6.5e-46, bitscore: 151.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSALPIETLVDPVTGIIRDVAPVEHPTGAPPRYTAMTADVADAR
                     RLGAWPADRVSLGTTFGDPRGAWIAAVAEAVERYCGNRLPPPGHPQEPRRATAAELAAE
                     GHRLYGPGALPAYAPWQYGRQGFPYAELTDDTPVLWTRAVEDGEPCWAPVALTHLNWRQ
                     GDLRSLTRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPASVP
                     GLTEDLAGCGLDVHIVEMPSEFAPCVAALVHDPGRGIHAAGFACRYDPAEAARKAVLEA
                     VHTWVFTQGAVDADGWVYRAVEAGMLARGLYLDHRADRRYLDDCGPEFAAVRDLGAHVQ
                     VWLDDRMAPLARRFTEPALGVVPVTGIAPGSRTALDAALATGGHRVITADLTTEDVAET
                     TLRVARVLVSGLIPNAPSAFGYFGCPRFADAALARGWRSRPPAGPEDFTLAPPPHM"
     gene            7165..8517
                     /locus_tag="BG84_RS0116360"
     CDS             7165..8517
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059076.1"
                     /locus_tag="BG84_RS0116360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_030081852.1"
                     /transl_table=11
                     /translation="MRQALADARSSRVPALSPYVPERPFPWNGQGLPVAGTGATAEGSI
                     DLDRVLRLSLAAPTGTPGRLRSVPSAGALHPVRAHLLLGPGCSLPPGRYAYDPRTHRAH
                     PRGPASADVPRGALVVLTVAASRTVAHYGHRAWPLLLLDTGHAAAALALAASPALDVRV
                     CLDADAALLSAAAGLPRAPDWQDAWPGTEPELPLAVVRLVRRGGRSADRGGALSAWAAL
                     PHGAAPAPLPGADTAPPRELAAARHLLDHIARAPEPTGGTWHPAARPKPVTDDVLEARR
                     SAPPGDLNHPPGNDLLARILATARTAHPAGPAWTAAAGGPAPALYASVPGRHGLGVRAS
                     GDARPTLAHWAARQQWVGTAGAVLLAHGCPEDAPPAAVRSSHLIAGYAVGAAQAHATAL
                     GLRSRPIGSWQQADLGAALGDTPGRDWIVHGLALGGGGSAPPSTPQPASPP"
     gene            8597..10336
                     /locus_tag="BG84_RS0116365"
     CDS             8597..10336
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="BG84_RS0116365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_030081854.1"
                     /transl_table=11
                     /translation="MMLHPELLRAANTARRPLGLATALLAAVTATHLAQAVLLALVLSR
                     IAQGQTAALAPLLTAVIAIVLVRAGLGRAQRLAAVTAGATVRVGLRDTLLRRLGALGPT
                     AITGARAGAVRATLVDGVEGVDAYISRYLPQSLITCAVPPLLLVAVALVEPYAALALGP
                     ALLLALFGPRWWDRLLARRGKEHWDSYEALAADYLEALQGMPTLRTAGAVGRVRERLER
                     RSAALHRTTVAKLRVSLVDTGLTDLAVQGGTVAAVLVACSSAATGRTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAALRTAEAAVPDRGTRAAVWKNAPEIRFEDVH
                     FTHPGSTRPALDGVSFTAAPGRTTAVVGPSGAGKSTLVSLLLRQRDPDRGRLTVAGTDT
                     AAYTLASLRRGIAVVSQETYLFHATIAENLRIARPAATDEQLRAAARTAGIDQEIARLP
                     DGYATLVGERGATLSGGQRQRLALARALLADAPVLILDEATSAVDERGQARIVRELTAA
                     GRGRTCVVVAHRLDAVRHADHIVVLDAGRVAAAGDHTTLLAGGGVYASLVAAGRTAQEE
                     RAA"
     misc_feature    complement(10937..10952)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.44"
                     /tool="antismash"
ORIGIN
        1 cgggctggga gtccccgacg gccgtggtcg tggcggcctg cgtcggcggc ttcgccggag
       61 cgggactgct gtggctgctc gccgggcggg accggggcga cccggaacag accgctgtct
      121 acggggtcct ggtgtccgcg gtgctcgccg gactcaccgc cgtcgtcctc ctggtggctc
      181 ccggtgaact cggcagcgtc gtccagtggt tgatcggctc cacggaaggc cgtgtgtggc
      241 agcactggaa tctgctctgg ccgtgggccg ccttctgggg tgcggccgcc tggctgctcg
      301 ccggaccgct gaccctgctg cgctgcggtg acgaacaggc cgcggcggcg ggtctggcca
      361 ccggccgggg acggggcgcg gcgctcgtct gcgcggtggc gctgacggcc ggagcggtct
      421 cggcggtggg cgcgctcggc ttcgtggggc tgctggtgcc gcatctggcg ctggcggtgt
      481 tcggtgcgga cctgcgcatc acgctcccgg gcgccgcgct gttcggtgcg gcggtggtgt
      541 gcggggcgga cgccgccgcc cagctgctgt cccggctgct ggccacggcg ttggaggcgg
      601 accggctgac ccttccggtc ggcgccctga ccacctttgt gggggcggcg ctgctgatgg
      661 tcgtggcgcg gcggagggcg gacgagcgat gacggcggtc cggcagggcg ccatggacgt
      721 gggcgcggac ggaacaacag gggtacagcg atgaggagag cggcatgccg gaaggcctga
      781 cggaacaagt ggacacgagc ccggcgaagg agcccggccc gggtgtcgaa tcccgggcgg
      841 agtccggtgc ggagcccggt ccggatgtcg tgcgggcgga agggctgacc ttcggctacc
      901 cggggcgcag ggtgctgagc ggggtggacc tgagcatccg ggccggcgaa ctggtcgccc
      961 tgatcgggct gaacggatgc ggcaagagca ccttcctcaa actcgccgca ggactcctga
     1021 ccccgagcgg cggccgcgtc ctgctcgaag gcgacgacgt ggcccggctg ccccgccgca
     1081 ccgcggcccg acgcgtcgct ctgctccatc aatcggcgcc gaccgtaccg gggttgaccg
     1141 tacgccagtt ggtgaggcaa gggcgctatg cggcccgggg gccgctgggg atgctgcggg
     1201 agggcgacga cgaggtgacg tcccgggcgc tcgcggacgt cggcgtcacc gcctgggccg
     1261 accggccggt ggacgcgctg tccgggggcg aacgccaacg ggtgcggctg gccatggcgc
     1321 tggcccagga cgcccgcgtg ctcttcctcg acgagccgac cacctatctc gatctgcggc
     1381 accagttgga ggtgctccag acggtcgtac ggctgcgcgc ggagcgccgg ttgacggtgg
     1441 tgatggtgct gcacgacctg aaccacgccg cccggttcgc cgaccggatc gtcgcgctgc
     1501 gcgagggccg cgtcgccgcc gacgggcccc cggccgaggt ggtcacccgg cagctgctgg
     1561 ccgaagtcct gggcgtggac ggccgggtgg ggatcgacag cgagggtggc tggccggtct
     1621 gttacccaga tcaccctctc gaaccgctcc agctattgcg gaatgaaaat catattcatt
     1681 agtgtctgtg ctgcggcacg cacgaacgca ccaccgcacc accgccgtgc ttcacaccca
     1741 tccgatccga ccgaatggag actccaactc atggagaaca acaaggtgtt cagcccgatc
     1801 gccgaccagg gccagctcgc ccacctgtcc gccacccact cgaacgccct cgtcgagaac
     1861 cccttcgacg acgccgtcga ggccgacacc gcgggcgaga agtgaccgaa gcctgccgct
     1921 gacggcaggt ttccccgcgt agcgcggggg cgggcccgcc cggtgactcc ccgggcgggc
     1981 ccgccccgtt cacccccgct gccctcgctc cccgtctctc cgaggcatcc cgtacccgcc
     2041 cgcattccgt atcccgtccc gccgcaccgg aggatcccgt gacccgcagt cgactcgctc
     2101 ccggcaccgg gatcgtcacc gcccccggag ccggccccgt gctccggacc tccggagggg
     2161 agttcctgcg catcgacacc ggcggtgtcg acgccggaac cctggtgcgc cgactggtgg
     2221 gggaggaggc gccggaagag ggtgcgcaca ccgctgaact caccaggctc atagcggcgt
     2281 tcgaggaggg cggacacgcg gtggccgcgc cgccccgggc cccgctcgcc ggtcgcaccg
     2341 tccacgtcct gggcgacccc gtgctcaccg ttccggtggc gcgctgcgcc ggggcggaag
     2401 gggccgaggt ccacgggacc accccggacc gggtggcgga actggccggg gcgacctcgg
     2461 accggagcgc cgatgggcgc gtggccgtgg tgtggtgcct cgactcgccc gtacccgagg
     2521 ggttttggga cacggcggac cggttgcccg ggcaaggcat cgcctggctg cggtgccacc
     2581 gcgagggggc tcacgtctgg accgagccgt tggcctcggc cccgggtgac gtcaccgccc
     2641 ggcacgtccg tctccgcaga ctcgcggcca ccgccgccca tcgcgaactc gccgcgtact
     2701 gggctggaca ccgcaccccg gacaccggac cgcacccgac cgaggcctcc gccgccctga
     2761 tcgccgggct cctcaccgcc gatctgatcg cctgggccga agccgaagcc gaagccgaag
     2821 ccgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3061 nnnnnnnnnn nnnnnagccg aagccgaagc cgaagccgaa gccgaagccg aagtcggtgc
     3121 cccactcgga actggtgccg gagcctcggt cgggccgggc gggtgcaccc gtctcccgcc
     3181 ccgccgtcgg ctgcgccgga tcgacctgcg ggatctcacc gtcaccgagc accccgtttt
     3241 ccccgtcccg gacgtcgcac cgctgcccgc ccccacacgg gtgacggccc acgccgaggc
     3301 cgggaccgcg aaggcgcgcc ggtgaacacc cgtaccgtgt acgtccccac gcccgacggc
     3361 atcgcgctcg ccaccgacgt atgcctcccg gacgggacgc gcccccggcc cgccgtcgtg
     3421 atcagaaccc cctacgggcg tgacgcccac cgcgccgagc tgcgcggctg ggcggcccac
     3481 ggattcgccg ccctggccca ggacgtacgc ggccgccacg gatcaccggg ggagtggcac
     3541 ccgtaccgag gccacgagat ggccgacggc accgccaccg tcgcgtgggt gcgcgcgcag
     3601 gcctggagca gcggtgaggt ggtcgccgtg ggcgcttcct acgcggcgca ctgcgcactg
     3661 gtcaccgcct tggtcacggc cgacggagcc cttctcggcg gagcccccga tgccgtcatc
     3721 gccgccgtcc ccgcgctcgg gctcaccgag acggcgcgcg agcccggcgg cccggagcgg
     3781 ctctgggccc gggcaggctg gtgggcggcc cacggcgacc gccgcgactc cgacccggac
     3841 gcgctggccc gtgccctggc ggacgacccc cggctgctcg aacaccttcc gatcgcccgc
     3901 ctggcggatc ggctggccga ggacctgggg cgccaactgc cctcctggcc acggctctgg
     3961 gccgaccgga gccggggccg gatcgtcgca cagggttccg cggcccgtct tccgctgctc
     4021 gccgtcggcg gcacccgtga ccccttcgcc gaggacaccg tggccctgtg gcacgcctgg
     4081 ggcggcccgt cccggctgct gctcggcccc tggggtcacc gcctcgccgc cgatccggcc
     4141 gtcccggccc gcgcccgcgt caacctcggt gcactgtacg tacggtgggc ccgcgcggcg
     4201 ctcgccggac agctggagcc gacgcggcac ggggtcatcg ccctcggcga cagcgggcgc
     4261 tggcacagca cgcgggtgcg cagcgctccc cggcctccgt cgccggacgg ccgccccgac
     4321 cgcgaccgcc gcacggtcgc caccgatgcc gcgtcccgcg ccacggccga agccgcagtc
     4381 cccgtacgcg tcctacccgc cgcgcctgcc cccttcccgg acgccgaccc ggtccgcacc
     4441 gtcgcctggc ccttcgactc gcccaccggc ctgcgactgc tccacggtgc cgagttcagc
     4501 gccgacccgg accgccccgt gcgctccgac gacctcgccg tcccggccgg cggtgaccgc
     4561 gccgaccgct gtctgcttct ctcgccgccg ctgccgcgcc cgctcgacct ggtgggagcc
     4621 gccgtcgccc ggatcaacgc cacggccgac gccccctgtg ccgactgggc cgtacgcctc
     4681 accgcgctcg acccgtccgg ccgcgcggat ccgctcgcct tcggcatcgt ccggcatacc
     4741 ggcccgcccg gtgaagccgc ggacatcacc gtgccgctcg gcacgctggg ccgtcgactg
     4801 cccgccggaa cccggttgcg ggccgagatc gccggacacc acttccccgc ccacgcccgt
     4861 aacccgcaca ccggcgagga cccggtcacg gccacccggc tcgtcacttc ccaccgcacc
     4921 gtgaaccccc ggggcagcgc cctccacctg cccgtcgtcg cccgacgccg ctacgtcgag
     4981 cccgtaccgg agatatgccg ttgaccagcg ccctgcccat cgaaaccctc gtcgatcccg
     5041 tcaccgggat catccgggac gtcgcacccg tcgaacaccc cacgggcgcg ccgccccgct
     5101 acaccgcgat gaccgcggac gtcgccgacg cccgccgtct gggcgcctgg cccgccgacc
     5161 gggtctcgct cggcacgacg ttcggcgacc cccggggcgc gtggatcgcc gcggtggccg
     5221 aggccgtcga gcgctactgc ggcaaccgcc tcccgccacc gggccacccg caggagcccc
     5281 ggcgggccac cgccgccgaa ctcgccgccg agggccaccg cctctacggg ccgggcgcgc
     5341 tgccggcgta cgccccctgg cagtacggcc ggcagggatt cccgtacgcc gaactcaccg
     5401 acgacacacc ggtgctgtgg accagggctg tcgaggacgg ggagccgtgc tgggcgcccg
     5461 tcgccctgac ccacctcaac tggcgtcagg gcgacctgcg ttcgctgacc cgcacccacc
     5521 atctcaacta cgcgggtatc gccaccggac agggcctgga cgacgccgtc gagcgcgggc
     5581 tcctcgaagt cgtcgagcgg gacgcgctgg agctgtggtg gcacctggac ggacccaccc
     5641 ggggcatcga cccggcgagc gttcccggac tcaccgagga cctggccggc tgcggtctgg
     5701 acgtgcacat cgtggagatg ccctcggagt tcgccccgtg cgtggcggct ctcgtgcacg
     5761 atcccgggcg cggcatccac gcggccgggt tcgcctgccg gtacgacccg gcggaggcgg
     5821 cccgcaaggc cgtgctggag gccgtgcaca cgtgggtgtt cacgcagggc gcggtggacg
     5881 ccgacggctg ggtgtaccgg gcggtggaag ccggcatgct ggcccgcggc ctctacctcg
     5941 atcaccgcgc cgaccggcgc tatctcgacg actgcgggcc cgagttcgcg gccgtccggg
     6001 acctcggcgc ccatgtccag gtctggctgg acgaccggat ggccccgctc gcccgccggt
     6061 tcaccgagcc cgcgctcggc gtcgtccccg tcaccgggat cgctcccggc agccgcacgg
     6121 cgctggacgc cgcgctcgcc accggagggc accgggtgat caccgcggac ctcaccacgg
     6181 aggacgtcgc cgagaccaca ctgcgcgtcg cccgcgtcct ggtctccggc ctgatcccca
     6241 acgcaccctc ggccttcggc tacttcggct gcccgcgctt cgcggacgcg gcgctcgccc
     6301 gggggtggcg atcccggccc ccggccggcc ccgaggactt caccctcgcc ccaccaccgc
     6361 acatgtgaag gagcgtggcc catgcccgac acaccggacc gaaccgccgc gcctgcttcc
     6421 ggggcaggcg tcgcgcagcc caccgcacct gcctcggcga cgcctgccgt gcagcctgac
     6481 ccgcctgctc ccggggcggg cgccgagctg ccggacgcgc ccgcggcgga ggcgtgcggg
     6541 gcaggggcgg cggggtccgt tccgaggacg cccggtgtgt cgcccgtcgc tcccgccgcc
     6601 ggggcgtgcg cggtcgggcc gacggggtcc gttcccggga cgctcggtgc gttgcctggc
     6661 gctcccgtgg ccggacccga gtcggcacgg ccgaccgcgc acgccctcgg ggcgcgtgcc
     6721 atgccgcccg ccgtgcccgc tcccggggtg cgggtcgcgc cgcccgacgt gcgggctgcc
     6781 ggggtgcggg tcacgccgcc gggcctgccg gctccggggg cgcccgccgt ttcgcctgtc
     6841 gcccctgccg tcggaccggt tcccgcgtgt cctgtcgcat ctgcctccgg gacatctgcc
     6901 gcgccgcgcg gcctgcctcc ctccggcgtg cgcgctgtgc cgcccgcacc cggaacacgt
     6961 tccgcgcggc ccgatacggg cggccccgga gtgcatgccg cacggaccac cgcccacgtt
     7021 ccaggggagc ccgccgtgcc atctgctgcc cgcgtgaccg gcccgaccgc cacgccgccc
     7081 gacgcccctc acccggcccg ggccaagagg ccggcttccg gtagcgacgt cgccaccggg
     7141 gcccggcccg ccgcaccggg cttcctgcgc caggcgcttg cggacgcccg ctcatcgcgt
     7201 gtccccgccc tctccccgta cgttccggag cgtccgttcc cgtggaacgg ccaggggctg
     7261 cccgtggccg ggaccggagc cacggccgag ggctcgatcg acctcgaccg cgtgctgcgg
     7321 ctgtcccttg ccgcgcccac cggaacaccc ggcagactgc gatccgttcc ctcggcgggc
     7381 gccctccacc cggtgcgcgc ccacctgttg ctcggtccgg gctgctcgct gccgcccggg
     7441 cgttacgcct acgacccgcg cacgcaccgc gcccacccgc gcggcccggc ctccgccgac
     7501 gtgccccggg gcgcgctcgt cgtcctcacc gtggctgcgt cccgtaccgt cgcccactac
     7561 ggtcaccggg cctggccgct gctgctcctg gacacgggac acgccgccgc cgcgctggcg
     7621 ctggccgcgt ccccggccct cgacgtccgg gtctgcctcg acgcggacgc cgccctgctg
     7681 tccgccgccg ccggactgcc ccgtgccccg gactggcagg acgcctggcc cggcaccgag
     7741 ccggaactgc ccctggcggt agtccggttg gtgcgccggg gcggccggtc ggcggaccgc
     7801 ggaggggcgt tgagtgcctg ggcggccctg cctcacggtg cggcccctgc gccgctaccc
     7861 ggtgcggaca cggccccgcc ccgcgaactc gccgccgcac ggcacctgct ggaccacatc
     7921 gcccgtgccc ccgagccgac cggcggtacg tggcacccgg ccgcgcgccc gaagccggtg
     7981 accgacgacg tcctggaagc gcgccgaagc gccccgcccg gcgacctgaa ccacccgccc
     8041 ggaaacgacc tgctcgcccg gatcctggcc accgcgcgga cggcacaccc cgccggaccc
     8101 gcctggaccg cggcggccgg aggccccgcc ccggccctgt acgcgtcggt gcccggccgc
     8161 cacggtctcg gcgtccgcgc ctccggcgac gcgcgcccca ccctcgcgca ctgggccgcg
     8221 cgccagcagt gggtcggcac agcgggcgcg gtactgctcg cccacggctg ccccgaggac
     8281 gcgccaccgg ccgcggtgcg cagcagccac ctcatcgccg gatacgcggt cggcgcggcc
     8341 caggcccacg ccaccgcact gggcctgcgc tcacgcccca tcggctcctg gcagcaggcc
     8401 gacctgggcg cggcgctcgg cgacaccccc ggacgcgact ggatcgtgca cggtctggcc
     8461 ctgggtggtg gcggctcggc acctccgagt acaccgcagc ccgcctcacc tccgtagtcc
     8521 gcagctctgg tcacacggcc gaaaaccaac ctccgacccg tcacccgacg gccccgccag
     8581 gcgaggaaga acgcccatga tgctccaccc cgaactcctg cgcgccgcga acaccgcgcg
     8641 ccgcccgctc ggcctcgcca ccgcactgct cgcggcggtc accgccaccc acctcgccca
     8701 ggccgtcctg ctcgccctcg tgctctcccg gatcgcgcaa ggacagaccg cagccctggc
     8761 cccgctgctc acggccgtca tcgccatcgt cctggtccgc gccggcctcg gccgcgccca
     8821 gcgcctggcc gccgtcacgg cgggagccac cgtacgggtc gggctccgcg acaccctgct
     8881 gcgacggctc ggggcgctcg gccccaccgc gatcaccggg gcgcgggccg gagccgtgcg
     8941 cgccacgctg gtggacgggg tcgagggcgt cgacgcgtac atctcgcgct atctgcccca
     9001 atccctcatc acctgcgccg ttccgccgct gctgctcgtc gccgtcgcgc tcgtcgagcc
     9061 gtacgccgcc ctcgccctcg gccccgccct gctgctggcc ctcttcgggc cgcgctggtg
     9121 ggaccggctg ctcgcccggc gcggcaagga gcactgggac tcgtacgaag ccctcgccgc
     9181 cgactacctg gaggccctcc aggggatgcc gaccctgcgc accgccggcg ccgtgggccg
     9241 ggtacgggaa cggctggagc ggcggtcggc cgccctgcac cggaccaccg tcgccaaact
     9301 ccgggtctcg ctggtcgaca ccggcctcac cgacctcgcc gtccagggcg gcacggtcgc
     9361 cgcggtcctc gtggcgtgct cctcggccgc caccggccgt accgccgcca ccggtaccta
     9421 cctcctgctc ctcctcgcct ccgaatgctt ccgccccgtg cgcgacctct cccgcgaatg
     9481 gcacgcgggc tacctcgggg tgtcggcggc cgacggcatc gccgccctgc gcaccgccga
     9541 agcggccgtg ccggaccggg gcaccagggc cgccgtctgg aagaacgcac ccgaaatccg
     9601 gttcgaggac gtgcacttca cccacccggg cagcacccgc cccgccctcg acggtgtcag
     9661 cttcaccgcc gcccccgggc gcaccacggc cgtcgtcggg ccctccgggg ccggcaagtc
     9721 gaccctggtg agcctgctgc tgcggcaacg ggacccggac cggggccgcc tcaccgtcgc
     9781 cgggacggac accgccgcgt acaccctcgc ctcgctgcgc cggggcatcg ccgtcgtctc
     9841 gcaggagacc tacctcttcc atgccacgat cgcggagaac ctgcgcatcg cccgcccggc
     9901 cgccacggac gaacaactgc gcgccgccgc ccgtaccgcc gggatcgacc aggagatcgc
     9961 ccggctgccg gacggttacg ccaccctcgt cggcgaacgc ggcgccacgc tctccggtgg
    10021 acagcgccaa cggctcgccc tcgcgcgggc gttgctggcc gacgcgcccg tcctgatcct
    10081 ggacgaggcc accagcgcgg tcgacgaacg cggccaggcg cgcatcgtcc gggaactgac
    10141 ggcggccggc cgcggccgca cctgcgtcgt cgtcgcccac cggctcgacg ccgtacgcca
    10201 cgccgaccac atcgtcgtcc tcgacgcggg ccgtgtcgcg gcggcgggcg accacaccac
    10261 cctgctcgcg ggcggcggcg tctacgcatc gctcgtcgcc gccgggcgca ccgcacagga
    10321 agagcgcgcc gcatgaaccc gacaccggat ccgacacgga ctccgacacc ggccccagcc
    10381 ccggcgtcaa acccgactcc gacaccgaca ccgacaccga cactggcccc ggcgtcaaac
    10441 ccgattccga ccccgacccc gaccccagcc ccggactcca cctcgactcc gccccaggcc
    10501 cccgccccgc cccaggcccc cacccccgaa accggcgccc tccgctcgct cctccccgtc
    10561 ctcggcgcgc accgcgccac cgtgctgcgc acctgcctgg ccgccctcgt cgaccaggcg
    10621 gccctggtcg ccctcgtcac gctcgccgcg tacaccgtgg gcaccgccgt caccgagcac
    10681 cggccgcccg cccccgggac catcgccctc ttggccgggc tcgtcctgct ccgggccctc
    10741 gccacctggc gcgagatgga cctctcgcac gacctcgcct accgggtcct cgccgaactg
    10801 cgcgtccggg tcttcgacgg gctggcccgc agcgcgcccg cccggatcgc cggccggcgc
    10861 agcggcgacc tcgcggccac cgcgctcggg gacgtcgagg cgctggagtt cttctacgcc
    10921 catgccatcg cccaactgct cgcgtccggc gtggtcttcg cggtgtcggc cgccgtgctg
    10981 gcggccctcg ggccctggct gctgctcgcc gtcgtgcccg ccgcgctgct cctgatctgg
    11041 tcgccgctct tcgaagcgcg cgggcgggcc gaacgcgggg cccggacccg gagcgcgctc
    11101 gccgaggtct cgtccgagac cgtggagagc gtcgacgggc tgcgcgagct cctgatggca
    11161 ggggccctga accgcaggcg ggcccggctc cggtccgccg ggcgtcggct cgcccgcgcc
    11221 cagcgcgccg aacagtcctg ggagaccggc gcgggcgcgg cccgcgatct gctggtcgtc
    11281 gccgccgtca tcgcggtcgt ggcggccgcc gcccacgccg cgtccgccgg acgcctggac
    11341 ggggcctggg ccccggcttc gatggccc
//
