LOCUS       NZ_KL573543            11350 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces baarnensis strain NRRL B-2842 P144_Doro1_scaffold5,
            whole genome shotgun sequence.
ACCESSION   NZ_KL573543
VERSION     NZ_KL573543.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces baarnensis
  ORGANISM  Streptomyces baarnensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 590083)
  AUTHORS   Doroghazi,J.R., Albright,J.C., Goering,A.W., Ju,K.-S., Haines,R.R.,
            Tchalukov,K.A., Labeda,D.P., Kelleher,N.L. and Metcalf,W.W.
  TITLE     A Roadmap for Natural Product Discovery Based on Large-Scale
            Genomics and Metabolomics
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 590083)
  AUTHORS   Doroghazi,J.R., Ju,K.-S. and Metcalf,W.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-APR-2014) Institute for Genomic Biology, University of
            Illinois at Urbana-Champaign, 3109 IGB, MC-195, Urbana, IL 61801,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: IDBA UD v. 1.0.9
            Genome Coverage                   :: 74x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 02:19:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,395
            CDSs (total)                      :: 7,345
            Genes (coding)                    :: 7,173
            CDSs (with protein)               :: 7,173
            Genes (RNA)                       :: 50
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 172
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 55 of 173
            Pseudo Genes (incomplete)         :: 138 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 27 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 113020
            Orig. end                         :: 124370
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KL573543.1.
            Bacteria available from NRRL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11350
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11350
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11350
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6350](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6350
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(297..312)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.1"
                     /tool="antismash"
     gene            complement(514..735)
                     /locus_tag="BG84_RS0110645"
     CDS             complement(514..735)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378551.1"
                     /locus_tag="BG84_RS0110645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_230543560.1"
                     /transl_table=11
                     /translation="MDVDTDDTHDTNGSYCEAPGPIAPAPPAGAAEGPPYAECVLCREP
                     TEYPESTKGATLCPVCAWQEAGRTACSG"
     gene            complement(757..1419)
                     /locus_tag="BG84_RS0110650"
     CDS             complement(757..1419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452202.1"
                     /locus_tag="BG84_RS0110650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_030079700.1"
                     /transl_table=11
                     /translation="MTALLRYQTAVLARSQRWLAPLLLYAAVLAVGVQGGQPVLGSLGV
                     AALLPVTAWAVHLCVTQEPPAARTVASAAVGPRRAHLAALLTATGCAAALAVVSTAVVL
                     LVSSPATDDGAHAVSRPSAALAGLAAALCCVLLGAVVGALSSRPVTVRRGWSVAAAVLG
                     SLLALVTTGSPARYAVTALVTGSRTGTFQPPALALLGAAALAGAVALAVCRLAARRG"
     gene            complement(1416..2387)
                     /locus_tag="BG84_RS0110655"
     CDS             complement(1416..2387)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536943.1"
                     /locus_tag="BG84_RS0110655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_078611120.1"
                     /transl_table=11
                     /translation="MLRGVDLALPVRALVRVEGANGVGKSTLLRLLAGIDAPAEGRITG
                     RPARTAYVPERFPAALPLTATGYLVHLGRIHGLRTAEAKRRAGEWLTRFGAADHARTPL
                     AELSKGTGQKVAVAQALPAAPDLLVLDEAWTGLDTAARAELDRTVAERVAAGATVVFVD
                     HDPRRLAGAADLTLRTADGGVHRATAATAPRPDPGPRVLIEAAGPPGATLPAALPGDPV
                     RERRSGTGGFGAGAAVSVPGGGTADYSPGPGPGDGPDHGAGSAVVSLTVPAPYSDALLA
                     ALLTARPPWHIRQVAPAQAPAPVTSPESPESSEAAAEVSEAS"
     gene            complement(2438..3112)
                     /locus_tag="BG84_RS0110660"
     CDS             complement(2438..3112)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="BG84_RS0110660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AIM24 family protein"
                     /protein_id="WP_030079702.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHMAQPATAPGMTLQNSKSIKYAVNGEMHARQGSMIA
                     FRGNLQFERKGQGIGGLLKRAVTGEGLALMAVRGQGEAWFAHEAANCFIVELDQGDSIT
                     INGRNVLCFDPTLSYEIKTVKGAGMVGGGLFNSVFTGYGKLGLMCEGTPIVIPVTAAQP
                     VYVDTDAVVGWSQQLATSLNRSQSVGSMVRGGSGEAVQLMLQGEGFVIVRPSEARPEKT
                     SN"
     gene            3183..3905
                     /locus_tag="BG84_RS0110665"
     CDS             3183..3905
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072531.1"
                     /locus_tag="BG84_RS0110665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_030079704.1"
                     /transl_table=11
                     /translation="MTSNDTPVSESPFHNGPTDRDQAPQFVLPLVLHLEKTDPPARTDA
                     LRTAARAVLTILSDERSLGDGEWAAAMRDWQDARIRKVVRRARGAEWRKVAALDGITVT
                     GEDGAEVRVFPPIPLDGWPKELAKLQVSGTDLEDPEPPAAPDLSGPVLWLNPEVDMSAG
                     KTMAQAGHGAQLAWWELSDAERKAWREAGFPLSVATPAPERWRELTVSGLPVVRDAGFT
                     EIAPGSCTVVADHPALRR"
     misc_feature    3208..3223
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.4"
                     /tool="antismash"
     gene            4124..4870
                     /locus_tag="BG84_RS0110670"
     CDS             4124..4870
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072530.1"
                     /locus_tag="BG84_RS0110670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_030079706.1"
                     /transl_table=11
                     /translation="MRRINGTALIIAALVATIGALAFPVWSYADRSGTGEANLNASSVA
                     TQWGPLSAIDRDFLVKVRLAGLWELPAGQQAIERAPSEATKAAGDHLVVGHADLDRRAR
                     DVAAKLGVELPNQPTAQQQEWLRELTAASGDEYERKFANILRAAHGKVFGLIGQVRHTT
                     RNTLIRQLASDANQTVLDHITMLEATGFVDFDALAREAASGSTASPSGPSMPRDGQVPP
                     APVPATPTGDQSFTSRPVPPTMMPMP"
     gene            5001..6350
                     /locus_tag="BG84_RS0110675"
     CDS             5001..6350
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072529.1"
                     /locus_tag="BG84_RS0110675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_030079708.1"
                     /sec_met_domain="DUF692 (E-value: 4e-91, bitscore: 299.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGIGIGWRPEIADEVEALAGIDWVEAVAENLCADHLPDSLVRL
                     RERGVTVVPHGVALGLGGADRPDPGRLSALAARAELLGAPLVTEHIAFVRAGGPLTASP
                     RLEAGHLLPVARARDALDVLCENVRIAQDSLPVPLALENIAALISWPGEELTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNLGQDPAKALDELPVEAIAYVHVAGGVEKNGVWHDTHA
                     HPVSAPVLEVLAELRSRVDPPGVLLERDDAFPPGTELAGELDAIRATLRRAATVHTPAE
                     SSERTDTAESGERTGVADPAPAEGRAAADPVPAGTRDRTAVAQTALLSALVAGTPAPEG
                     FDHRRLRVQSRALAAKRADVVAKVAPELPEILGDGYRPAFLAYAGSRPMSGGYRRDALD
                     FAEHVLIAGGPADPVARRRLTYWWQDRSGARPPGRTTRLVRAARAVLVGK"
     gene            6356..7396
                     /locus_tag="BG84_RS0110680"
     CDS             6356..7396
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514514.1"
                     /locus_tag="BG84_RS0110680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_030079710.1"
                     /transl_table=11
                     /translation="MNVFAVLATLGVVVSSVLLVVKAVAERSRRPAPGPGVALHDLYEV
                     AFLNGGPARVVDTALASLHADGRLAVGGPGIVAVQRAQANDPVERAVFQELAAAPSGAL
                     HVLREAVMRHPAVQEVGDGLAARGLLVPPHRIRPLRRWGLIQGVACLIALPLSLVVTFV
                     QLAVVDTMDFPVPFIVKILPAIVIGAFSGLIVAGASASRITKSGQHAALAFRTAYAHVV
                     TPAHLVATLGLRALPDPVLQAQLVAAARLSAPRRRSSSYVAGSTAAGVTAVGVATVWCA
                     AGPGGSSCGGSTGGGSGSSCGGGSGCSSGSGCSSGSGCGGSSGSSCGSSGGSSCGGGGG
                     GCGGGS"
     gene            7556..9118
                     /locus_tag="BG84_RS0110685"
     CDS             7556..9118
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (101-476). E-value:
                     3.4e-19. Score: 61.4. Matches aSDomain:
                     nrpspksdomains_BG84_RS0110685_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956907.1"
                     /locus_tag="BG84_RS0110685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_030079712.1"
                     /sec_met_domain="PF00561 (E-value: 1e-25, bitscore: 85.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAALYTSIGSLVLSALAAAPANAWEAPGSAESRGTAIAAARAT
                     AAGIDFAACPEEEMLPDSLKCGTVKVPLDYAEPDGRQLELTVSRTPATGPAQERQGAFV
                     YNPGGPGASSITFPLAGELPEWKEIAEAYDLVGYAPRGVNGSSAPLSCQDPAAYTKGPT
                     DAPTHPTQAYKERRVARAKAYARGCAEHAGATLRHYTSLNNARDLDVLRAALGESRLTF
                     MGASYGTYFGALYATLFPSHVRRMVFDSVVDPDPEQIWYRSNMDQSLAFETRWEDFRRW
                     VARHDDVYHLGTTPEAVQQHYDEVRAELAVKPAGGTVGPGQLHSAFLGAGYYDDYWAMR
                     ATALSEYVRGNPEPLVAQASPRAVAAKDNENAQAVYTAVECNDAPWPEEFEVWDRDHTD
                     LARVAPFETWDNAFTNLPCAFWPAPRQRPLEVGTRWGELPPVLILAAERDAATPYKGAL
                     ELRKRLPGSSLVTERGAGTHGVGGAGNTCVDDHLRRYLLTGEVPGRGADCAAHPEPNPV
                     SLD"
     aSDomain        7859..8983
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BG84_RS0110685_Abhydrolase_1.1"
                     /evalue="3.40E-19"
                     /label="BG84_RS0110685_Abhydrolase_1.1"
                     /locus_tag="BG84_RS0110685"
                     /protein_end="476"
                     /protein_start="101"
                     /score="61.4"
                     /tool="antismash"
                     /translation="AFVYNPGGPGASSITFPLAGELPEWKEIAEAYDLVGYAPRGVNGS
                     SAPLSCQDPAAYTKGPTDAPTHPTQAYKERRVARAKAYARGCAEHAGATLRHYTSLNNA
                     RDLDVLRAALGESRLTFMGASYGTYFGALYATLFPSHVRRMVFDSVVDPDPEQIWYRSN
                     MDQSLAFETRWEDFRRWVARHDDVYHLGTTPEAVQQHYDEVRAELAVKPAGGTVGPGQL
                     HSAFLGAGYYDDYWAMRATALSEYVRGNPEPLVAQASPRAVAAKDNENAQAVYTAVECN
                     DAPWPEEFEVWDRDHTDLARVAPFETWDNAFTNLPCAFWPAPRQRPLEVGTRWGELPPV
                     LILAAERDAATPYKGALELRKRLPGSSLVTERGAG"
     gene            complement(9267..9995)
                     /gene="hemQ"
                     /locus_tag="BG84_RS0110690"
     CDS             complement(9267..9995)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965515.1"
                     /locus_tag="BG84_RS0110690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_030079714.1"
                     /transl_table=11
                     /translation="MSAPETVTSSKSPNAGKKAKDLNEVIRYTLWSVFKLRDVLPLDRA
                     GYADEVQELFDQLAAKDVTVRGTYDLSGLRADADIMIWWHAETSDQLQDAYNLFRRTKL
                     GRALDPVWSNMALHRPAEFNKSHIPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRM
                     LADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARLHVRE
                     EVPFYTGRRKSVADLVAGLA"
     misc_feature    10406..10422
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.3"
                     /tool="antismash"
     misc_feature    complement(10863..10872)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(10958..10973)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.74"
                     /tool="antismash"
ORIGIN
        1 ctggcgctac gccagccatc ggcccaaatc ggtgctgggt gagcggatcc ggctcgacgc
       61 gacggcgtac gggcggcgca tgatgggcag ttggtcagcc cgtaaggggt tcttcctgcg
      121 cgccgagacg gcgctggacg ccctggaccg ggaagggttc gcaccggact cggtcagtca
      181 cggcgagggc ttcctcgccg cgttccgggg caagttcttc cggccggggc tctatgtgat
      241 ggacgagccg gaggccgcgc tgtcgttctc ctcctgcctg gaactgctcg gtcacatcga
      301 ccaactggtg aagaacggcg gccaggtcat ctgcgccacc cactctcccc tcctgaccgc
      361 ctttcccggc gcggacatcg tggagatcgg cgagcacggc atgcgccgcg tggcctggag
      421 cgacttggct ctggtcgatc actggcgccg ctacctcgcc gacccgcagt cctatctgcg
      481 gcacgtcctc ggctgaaccg gttacgggag ccctcagccg gaacaggccg tgcggcccgc
      541 ctcctgccag gcgcagaccg ggcagagcgt ggcgcccttc gtcgactccg ggtactcggt
      601 cggctcgcgg cacagcacgc actcggcgta gggagggccc tcggcggctc cggcgggcgg
      661 ggcgggcgcg atcggtcccg gggcctcgca gtacgaaccg ttcgtgtcgt gcgtgtcgtc
      721 ggtgtccacg tccacgagcc tacgcatccg cccggctcat ccgcgccggg cggcgagccg
      781 gcagaccgcg agcgccaccg ccccggcgag agccgccgcc ccgagcaggg ccagggcggg
      841 cggctggaac gtcccggtcc gtgatcccgt gaccagggcg gtgaccgcgt aacgcgccgg
      901 ggatccggtg gtcaccagcg ccaggagcga gccgagcacc gccgccgcca cggaccagcc
      961 ccggcggacc gtcaccgggc ggctgctgag cgcccccacg accgcgccca gcaggacgca
     1021 gcacagggcg gccgccagtc cggcgagcgc ggcggacggt cgggagaccg cgtgggcgcc
     1081 gtcgtcggtg gccgggctgc tgacgagcag gacgacggcg gtgctcacca cggcgagcgc
     1141 cgccgcgcag cccgtggcgg tgagcagcgc ggccaggtgc gcccgccggg ggcccacggc
     1201 ggccgaggcg accgtccggg cggcgggcgg ctcctgggtg acgcagaggt ggacggccca
     1261 cgcggtcacg ggcagcaggg cggcgacgcc gagcgagccc agcacgggct gcccgccctg
     1321 cacgccgacg gcgaggacgg ccgcgtacag caggaggggc gccagccagc gctgggagcg
     1381 ggcgagcacg gcggtctggt agcggaggag ggcggtcatg atgcttcgga cacctctgcc
     1441 gctgcctcgg aggactcggg tgactcgggt gacgtgaccg gtgcgggggc ttgtgccggg
     1501 gcgacctgtc ggatgtgcca cggcgggcgg gccgtgagca gggctgccag gagcgcgtcg
     1561 gagtacgggg cggggacggt gaggcttacg acggcggagc ccgcgccgtg gtcgggtccg
     1621 tcacccgggc cggggccggg gctgtagtca gcggtgccgc cgcccgggac ggagacggcc
     1681 gcacccgcgc cgaagccgcc cgtcccgctc ctccgctccc ggaccgggtc gcccggcagg
     1741 gccgcgggca gcgtcgcgcc cggtgggccc gccgcctcga tcaggacccg ggggccgggg
     1801 tcggggcggg gcgctgtcgc agccgtcgcc cggtgcaccc cgccgtcggc ggttcgcagg
     1861 gtgaggtccg ccgccccggc caggcgtcgc gggtcgtggt cgacgaagac gacggtggcg
     1921 ccggccgcca cgcgttcggc cacggtgcgg tccagctcgg cgcgggccgc ggtgtccagg
     1981 ccggtccagg cctcgtccag aaccagcagg tccggcgcgg ccggcagcgc ctgggcgacg
     2041 gcgaccttct ggccggtgcc cttggagagt tccgccagcg gggtacgggc gtgatccgcc
     2101 gcgccgaacc gggtcagcca ctcccccgcc cgccgcttcg cctcggccgt ccgcagtcca
     2161 tggatccggc cgaggtggac gaggtagccg gtggcggtca gcggcagcgc ggccgggaag
     2221 cgctcgggaa cgtatgccgt acgggccggg cggccggtga tccgtccctc ggcgggggcg
     2281 tcgatcccgg cgagcagccg cagcagggtc gacttgccga ccccgttggc cccctcgacc
     2341 cggacgagcg cccgcacggg cagcgcgagg tcgaccccgc gcagcaccca ggctccgcgg
     2401 aggccgtacc ggtggcccac tccccggaga tgcagggtca gttggaggtc ttctcgggcc
     2461 gggcctcgct gggccgcacg atgacgaagc cctcgccctg gagcatcagc tgaaccgcct
     2521 cgccggagcc gccacgcacc atcgagccga cgctctggga gcggttgagg ctggtcgcga
     2581 gctgctggct ccagccgacg accgcgtccg tgtccacgta caccggctga gcggccgtca
     2641 cggggatcac gatcggcgtg ccctcgcaca tcaggccgag cttgccgtaa ccggtgaaga
     2701 cgctgttgaa gaggccgccg ccgaccattc cggcgccctt caccgtcttg atctcgtagg
     2761 agagcgtcgg gtcgaaacac aggacgttgc ggccgttgat ggtgatggag tcgccctggt
     2821 ccagctccac gatgaaacag ttcgccgcct cgtgcgcgaa ccacgcctcg ccctggcccc
     2881 ggaccgccat cagcgcgagg ccctcaccgg tgaccgcgcg cttgagcagg ccgccgatgc
     2941 cctggccctt gcgctcgaac tggaggttgc cgcggaaggc gatcatcgaa ccctgccggg
     3001 cgtgcatctc cccgttgacg gcgtacttga tcgacttgga gttctgcagg gtcataccgg
     3061 gggcggtggc cggctgggcc atgtgctcgc tggaaaagag atcgctcttc atgcggagca
     3121 tcctcacccg gagccggtcg ttccgccaag gaggtgaacc gaccacctgg cagactgggg
     3181 cggtgaccag caacgacacc cctgtctccg aaagcccgtt ccacaacggt ccgaccgacc
     3241 gcgaccaggc gccgcagttc gtgctgccgc tggtgctcca cctggagaag acggacccgc
     3301 ccgcccgtac cgacgcgctg cggaccgccg cccgtgcggt gctgacgatc ctctccgacg
     3361 agcggtcgct cggcgacggc gagtgggccg cggcgatgcg ggactggcag gacgcccgga
     3421 tccgcaaggt cgtgcgccgg gcgcgcggtg cggagtggcg caaggtcgcg gcgctggacg
     3481 gcatcacggt gacgggcgag gacggcgcgg aggtacgggt gttcccgccg atcccgctgg
     3541 acggctggcc caaggagctg gccaagctcc aggtgtcggg caccgacctg gaggaccccg
     3601 agccgcccgc cgcgcccgat ctctcgggcc cggtgctgtg gctgaacccc gaggtggaca
     3661 tgtcggcggg caagacgatg gcccaggccg ggcacggggc gcagctcgcc tggtgggagc
     3721 tgtccgacgc cgagcgcaag gcctggcgcg aggccgggtt cccgctctcc gtcgccaccc
     3781 ccgccccgga gcgctggcgg gagctgacgg tgagcgggct gccggtggtg cgcgacgcgg
     3841 ggttcaccga gatcgccccg ggctcctgca cggtggtcgc cgaccatccg gcgctgcgcc
     3901 gctgagcggg gcggtgaccg cgacggatcg cccgtgtcgc ggagccgccg agcgggacac
     3961 gaccacatcg ccgccgtgct gaacgtttcc ggtcccttct ccgtatctcc cggtactgcc
     4021 ctttcggcat taccgccaag tagcctgcgc agccggtcga ctggcggttg attgacgcct
     4081 gttcgatcga cgctgccacg cctcggcccc gggagacacc ttgttgcgac gcatcaacgg
     4141 aacggccctc atcatcgcgg cgctggtcgc caccatcggc gcgctcgcgt tccccgtctg
     4201 gtcctacgcg gaccgttcgg gcaccggcga ggcgaacctc aacgcctcca gtgtcgcgac
     4261 ccagtgggga ccgctctccg cgatcgaccg ggacttcctg gtcaaggtgc ggctcgccgg
     4321 gctgtgggag ctgcccgccg ggcagcaggc gatcgaacgg gcgcccagcg aggcgacgaa
     4381 ggccgccggg gaccacctcg tcgtcgggca cgccgatctg gaccggcggg cccgggacgt
     4441 ggcggcgaag ctcggggtgg agctgcccaa ccagccgacc gcccagcagc aggagtggct
     4501 gcgggaactg acggcggcga gcggggacga gtacgagcgg aagttcgcca acatcctgcg
     4561 cgccgcccac ggcaaggtct tcggcctgat cggccaggtc cgccacacca cccgcaacac
     4621 gctgatccgg cagctggcga gcgacgccaa ccagaccgtg ctggaccaca tcaccatgct
     4681 ggaggccacc gggttcgtcg acttcgacgc cctggcgcgc gaagcggcga gcgggtcgac
     4741 cgccagtccc tccggcccgt cgatgccccg ggacggccag gtcccgccgg ccccggtgcc
     4801 ggcgacgccg accggtgacc agtccttcac ctcgcggccg gtgccgccca cgatgatgcc
     4861 gatgccataa cgaggccgcc ggtcccggaa cctcaaatcc agctctgaac gtcccctctg
     4921 tcgggttcag caccgttcga cggggtcatg accccgggac agaacgacag agcgaaggcc
     4981 tgggtgagca gggggacacc atgaagctgg gcatcggtat cggctggcgg ccggagatcg
     5041 cggacgaggt ggaggcgctg gcggggatcg actgggtcga ggccgtcgcg gagaacctct
     5101 gcgccgacca tctcccggat tccctggtac ggctccggga gcgcggggtg accgtcgtgc
     5161 cgcacggggt ggcgctcggg ctcggcggtg cggaccggcc cgaccccggc cgcctctccg
     5221 ctctcgcggc gcgcgccgaa ctgctggggg cgccgctggt gaccgagcac atcgcgttcg
     5281 tacgggccgg ggggccgctg accgcgtcac cgaggctgga ggcggggcat ctgctgccgg
     5341 tggcccgtgc ccgggacgcg ctggacgtgc tgtgcgagaa cgtgcggatc gcgcaggact
     5401 cgctgccggt gccgctcgcc ctggagaaca tcgcggcgct gatctcctgg ccgggcgagg
     5461 agctgaccga ggggcagttc ctcgcggagc tggtcgagcg gaccggggtg cggctgctga
     5521 tcgacgtggc caatctgcac accaaccacg tcaacctcgg ccaggacccg gcgaaggcgc
     5581 tggacgagct gccggtggag gccatcgcgt acgtgcatgt ggcgggcggg gtcgagaaga
     5641 acggcgtctg gcacgacacg cacgcccacc cggtgtccgc acccgtcctg gaggtgctgg
     5701 ccgagctgcg ctcccgggtc gacccgccgg gcgtgctgct ggagcgggac gacgcgttcc
     5761 cgccgggcac ggagctggcg ggcgaactgg acgcgatccg ggcgacgctg cggcgggcgg
     5821 cgaccgttca cacgccggcc gaatccagtg aacgtacgga caccgccgaa tccggtgagc
     5881 gtacgggcgt cgccgacccc gcgcccgccg aaggccgcgc cgcggccgac cccgtgccgg
     5941 ccggcacccg tgaccgtacc gccgtcgcgc agaccgcgct gctctccgcc ctggtggccg
     6001 ggaccccggc ccccgagggc ttcgaccacc ggcggctgcg ggtgcagagc cgggcgctgg
     6061 ccgccaagcg cgccgacgtc gtcgccaagg tggcccccga gctgccggag atcctcggcg
     6121 acggctaccg ccccgcgttc ctcgcgtacg ccggcagccg cccgatgtcc ggtgggtacc
     6181 gccgcgacgc cctggacttc gcggagcatg tgctcatcgc gggcggtccc gccgatccgg
     6241 tggcgcggcg ccggctgacg tactggtggc aggaccggtc gggcgcccgg ccgccgggcc
     6301 gcaccacccg tctggtccgg gcggcccgtg ccgtcctcgt ggggaagtga ccgctgtgaa
     6361 cgtcttcgct gtgctggcga ccctcggggt cgtcgtctcg tcggtgctgc tcgtcgtgaa
     6421 ggcggtggcc gagcggtccc gccgccccgc cccggggccc ggcgtcgccc ttcacgacct
     6481 gtacgaggtc gcgttcctca acggcggtcc ggccagggtg gtggacaccg ctctcgcctc
     6541 gctgcacgcg gacggccggc tggccgtcgg cgggcccggc atcgtcgccg tacagcgggc
     6601 gcaggcgaac gacccggtgg aacgcgcggt gttccaggag ctggccgccg ccccgagcgg
     6661 cgccctgcac gtcctgcggg aagcggtgat gcgccacccg gcggtccagg aggtcggcga
     6721 cgggctcgcc gctcgcgggc tgctggtgcc gccccaccgg atccggccgc tgcggcggtg
     6781 ggggctgatc cagggggtgg cgtgcctcat cgccctgccg ttgagcctgg tggtcacgtt
     6841 cgtccagctc gcggtggtcg acaccatgga cttcccggtc ccgttcatcg tgaagatcct
     6901 gcccgcgatc gtgatcggcg cgttcagcgg cctgatcgtc gcgggcgcct ccgcgagccg
     6961 catcacgaag tcggggcagc acgccgccct ggcgttccgg accgcctacg cccatgtggt
     7021 gacgcccgcc cacctcgtcg ccacgctggg gctccgcgcg ctgccggacc cggtgctcca
     7081 ggcccagctg gtggccgcgg cacggctgag cgctccgcgc cggcggtcct cgtcgtacgt
     7141 cgccgggtcc acggcggcgg gcgtcaccgc cgtcggcgtc gcgacggtct ggtgcgccgc
     7201 cggccccggc ggctccagct gcggcgggtc gaccgggggc ggctccggat cgagctgcgg
     7261 cggcgggtcc ggatgctcct cggggtccgg gtgctcctcc gggtccgggt gcggaggcag
     7321 cagcggttcg agctgcggca gctcgggcgg ctccagctgc gggggcggtg gcggcggctg
     7381 cggcggcggg tcctgaaccg ctcctgatcc gctcctgatc cgcgcgaacc gaggccgctc
     7441 gtacggttgt tgaccgccca tcagggtggt tcccggtgac attccggggc ggtactggac
     7501 atcggcgccc gtccgcccga ccatccctct ccgcatccgc agagaggccc cgcgcgtgag
     7561 aacagctgcg ctgtacacat cgatcggctc cctggtcctg tccgccctgg ccgccgctcc
     7621 cgcgaacgcc tgggaggcgc cgggctccgc cgagtcccgg ggcaccgcga tcgccgccgc
     7681 ccgggccacc gccgccggga tcgacttcgc cgcctgcccc gaggaggaga tgctcccgga
     7741 ctccctgaag tgcggcacgg tgaaggtgcc cctcgactac gccgagccgg acgggcggca
     7801 gctcgaactg accgtcagcc gcacgcccgc caccggtccg gcgcaggagc ggcagggcgc
     7861 gttcgtctac aacccgggtg gccccggcgc gtccagcatc accttcccgc tggccgggga
     7921 gctgccggag tggaaggaga tcgccgaggc gtacgacctg gtcggctacg ccccgcgcgg
     7981 ggtgaacggc tcctccgccc cgctgtcctg ccaggacccc gccgcgtaca ccaagggtcc
     8041 gacggacgcg ccgacgcacc cgacgcaggc gtacaaggag cggcgcgtcg cccgtgcgaa
     8101 ggcgtacgcg cggggctgcg cggagcacgc gggcgcgacg ctgcggcact acacctcgct
     8161 gaacaacgcc cgtgacctgg acgtcctgcg ggccgcgctc ggcgagagcc ggctgacgtt
     8221 catgggggcg tcgtacggga cgtacttcgg cgcgctgtac gcgacgctgt tcccctcgca
     8281 cgtacggcgg atggtcttcg actcggtggt cgacccggac ccggagcaga tctggtaccg
     8341 ctccaacatg gaccagtcgc tggccttcga gacgcgctgg gaggacttcc gccgctgggt
     8401 cgcccggcac gacgacgtgt accacctggg gaccaccccg gaggcggtgc agcagcacta
     8461 cgacgaggtg cgcgccgagc tggcggtgaa gccggcgggc ggcacggtgg gtccggggca
     8521 gctgcattcg gcgttcctgg gggccggtta ctacgacgac tactgggcga tgcgggcgac
     8581 ggccctgtcg gagtacgtgc ggggcaaccc ggagccgctg gtcgcacagg cctccccgcg
     8641 tgcggtggcg gcgaaggaca acgagaacgc gcaggcggtg tacacggcgg tcgagtgcaa
     8701 cgacgcgccc tggccggagg agttcgaggt ctgggaccgc gaccacacgg acctggcgcg
     8761 ggtcgctccc ttcgagacct gggacaacgc cttcaccaac ctgccgtgcg ccttctggcc
     8821 cgcgccccgg cagcggccgc tggaggtggg gacgcggtgg ggcgagctgc cgccggtgct
     8881 gatcctggcg gcggagcggg acgcggcgac gccgtacaag ggggcgctgg agctgcggaa
     8941 gcggctgccc ggctcgtcgc tggtgaccga gcggggcgcg gggacgcacg gcgtcggcgg
     9001 ggccgggaac acctgcgtgg acgatcatct gcgccggtat ctgctgaccg gtgaggttcc
     9061 ggggcggggt gcggactgtg ccgcgcaccc ggagccgaac ccggtgtcgc tggactgagc
     9121 tgagtacgga gcgggggccg ccgcaccttt acggtgcgac ggcccccgaa gccgaacccg
     9181 gtgtcgctgg aggggcggac ggcacgatcg gtgcccggtg cccgtccctc tgatcttccg
     9241 ggttggggtg gtgcgggact cgctggttat gcgagcccgg ccaccaggtc tgcgacgctc
     9301 ttcctgcggc ccgtgtagaa cgggacctcc tcgcgcacgt ggagccgtgc ctcggaggcg
     9361 cgcaggtgac gcatcaggtc gacgatgcgg tacagctcgt ccgcctcgaa ggcgaggatc
     9421 cactcgtagt cgccgagcga gaacgaggcg acggtgttgg cgcggacgtc cgggtaaccc
     9481 cgggccatct tgccgtggtc cgcgagcatg cggcggcggt cctcgtcggg cagcagatac
     9541 cagtcgtagg accggacgaa ggggtagacg ctgatgtagt cgcggggcgt ctcgtcggcg
     9601 aggaacgccg ggatgtgcga cttgttgaac tcggcggggc ggtgcagcgc catgttcgac
     9661 cagaccgggt cgagcgcgcg gccgagcttg gtgcgcctga agaggttgta cgcgtcctgt
     9721 agctggtccg aggtctccgc gtgccaccag atcatgatgt ccgcgtcggc ccgcagcccg
     9781 gagaggtcgt aggtgccccg gacggtgacg tccttggccg cgagctggtc gaacagctcc
     9841 tggacctcgt cggcgtaacc ggcgcggtcc agcgggagga cgtcgcgcag tttgaagacc
     9901 gaccacaggg tgtagcggat gacctcgttg aggtccttgg ccttcttgcc ggcgttcgga
     9961 ctcttgcttg atgtcacagt ctcaggagca ctcatacggc tattgtcccg cctcgctccc
    10021 cgtgccccga accagggtcg gcgtggcgat gatctccctg gtgatctcgt cggccgcccg
    10081 gtgggcgctc gcgatgcagg cggggatgcc gacgccgtcg tagaccgcgc cgcagacccg
    10141 cagggcgggc agcttggcga cctcgtcgcg gatccgggcg acccgggtga ggtggccgac
    10201 cgggtactgc ggcagtccgc cgatccagcg ggtgacctcg ctgtcgacgg gccgggcggt
    10261 gagtccggtg gccgcggcga ggtcgcgcag ggacacggag accagttcct cgtcctcgcg
    10321 gtggaggtgg tcctcctcgc cgtaccggcc gacggaggtg cggagcacga agaggccggg
    10381 ggcggcgtcg gcgacccact gccatttgtt gctggagaac gtggacgcct tgatggtgtg
    10441 cccgtcgacc ggcggtacga ggaagccgga gcggccgcgc agggccgagt acgcctcgat
    10501 gtcggtacgc cggaaggcca gggtgaccag ggccatcgag gcgtactcga cgccggacag
    10561 ctcggcggag gcggccgggg actcggcggc cagcagggtg ccggcggacc aggcgggggt
    10621 ggccaggacg atgccgtcgg cggcgatcgt ccgggcgtcg gtgcggacgg cccagcccgt
    10681 ttccgtacgg gtgagaccga ggacgggcgt ctcggtgagg atgtcgccgc ccccggcccg
    10741 tacggcgtcg ccgacggcgg ccgggagggt gccgatgccg ccctcgatgc cctggaagac
    10801 cgggccggcc tgctgccggg ccgccgcgcg ttcctggatg cggcccacgg cctccagcag
    10861 cgggccgcct tccttcaccg cttcgaagag ctggggtacg gcggcgcgca tcgagatccg
    10921 gtaggcgtcg cccgcgtaga ccccgccgag gaggggctcc accagccggt ccacgacctc
    10981 gcggccgagc cggtcggcga cgtacgcgcc gaccgcgacg tcctcgccca cgggcgtcgg
    11041 ggtgaggtcg cgctcctcgg cgatccgggc caggccctcg ggtgacagca cctcgccgag
    11101 gaccgcgggg tcgccgggga cgcccatgac atggcccttg ggcatggggc gcagcgcgtc
    11161 gcgggtccag agcgaggcgg tggcggtggc gggcggctgg aggcggtcgg cgaggcccac
    11221 cgcctcggcc agggcgaccg cctcggggcg ccgggcgagc atcgactcgg cccccaggtc
    11281 gacctggacg cccgcgacct cgccggtcat gagcttgccg ccgagccggt ccgtggcctc
    11341 caggagggtg
//
