LOCUS       NZ_KL503830            10216 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Streptomyces griseorubens strain JSD-1 scaffold1, whole genome
            shotgun sequence.
ACCESSION   NZ_KL503830
VERSION     NZ_KL503830.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces griseorubens
  ORGANISM  Streptomyces griseorubens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces althioticus group.
REFERENCE   1  (bases 1 to 7563100)
  AUTHORS   Feng,H., Zhi,Y., Sun,Y., Wei,X., Luo,Y. and Zhou,P.
  TITLE     Draft Genome Sequence of a Novel Streptomyces griseorubens Strain,
            JSD-1, Active in Carbon and Nitrogen Recycling
  JOURNAL   Genome Announc 2 (4), e00650-14 (2014)
   PUBMED   24994798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7563100)
  AUTHORS   Feng,H., Sun,Y., Zhi,Y., Mao,L., Luo,Y., Wei,X. and Zhou,P.
  CONSRTM   Shanghai Jiao Tong University
  TITLE     Draft genome sequence of the novel Streptomyces griseorubens JSD-1
            playing a role in carbon and nitrogen cycle
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7563100)
  AUTHORS   Feng,H., Sun,Y., Zhi,Y., Mao,L., Luo,Y., Wei,X. and Zhou,P.
  CONSRTM   Shanghai Jiao Tong University
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2014) School of Agriculture and Biology, Shanghai
            Jiao Tong University, Shanghai Jiao Tong University, Shanghai,
            China, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2013-12-24
            Genome Coverage                   :: 246x
            Sequencing Technology             :: Illumina Miseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000709915.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 03:19:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,036
            CDSs (total)                      :: 6,948
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 329
            CDSs (without protein)            :: 328
            Pseudo Genes (ambiguous residues) :: 0 of 329
            Pseudo Genes (frameshifted)       :: 72 of 329
            Pseudo Genes (incomplete)         :: 272 of 329
            Pseudo Genes (internal stop)      :: 8 of 329
            Pseudo Genes (multiple problems)  :: 23 of 329
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7128673
            Orig. end                         :: 7138889
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KL503830.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="19"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1855..4077)
                     /locus_tag="DJ64_RS31850"
                     /old_locus_tag="DJ64_22135"
     CDS             complement(1855..4077)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="DJ64_RS31850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_22135"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_033275281.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.4e-38, bitscore:
                     130.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAQETRGRRRAAPPRRKVPKSRAKTVRTPTVLQMEAVECGAAS
                     LAMVLGHHGRHVPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDLAALAEVTS
                     PAILFWEFNHYVVYDGMGRRFGRRGVYVNDPAKGRRFVPLEEFDGSFTGVVLVMEPGDD
                     FTRGGRKPGVLGAMPARLRGTAGTMPAVVLTSLLLVAVGAALPGLSRTFIDEFLIGQQT
                     SMLDVLFASMGACVLLTLLLTWLQQANLLRGRLISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLSAAGVDAVVVVLYAVLLYTYDPQLTFVGIGVALLNIL
                     AMRIVIRLRATRTAKLRADTARLTNTAYTGLQLIETLKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSALILWIGGMRAVEGHISVGLLVAFQALVARFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFRTDPLYGRPGAGESTRRLHGHVELQNLTFGYNP
                     LDKPLLTGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYTPWEGVIRIDGQRIEDIPR
                     GALAASVSFVDQDVFLFEGTVRDNVALWDPSIPDEAVVEALKDAALYDVIVRRPGGIHS
                     PVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRRRGCACV
                     VIAHRLSTVRDSDEIVVLDQGTVVERGRHEELVARGGAYAALVRER"
     gene            complement(4074..4880)
                     /locus_tag="DJ64_RS31855"
                     /old_locus_tag="DJ64_22140"
     CDS             complement(4074..4880)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="DJ64_RS31855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_22140"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_033275280.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEDLDLPVRFARPQGWLVLSVTVIAMAAASVW
                     ALTGSVTSTVQAPAILTYGQGSYILQSPVAGQVTAVLAREGERLPANSPVLKVRTPDGD
                     QVVRTLQAGRITALAASAGQIISTGADVAAVEKVRGDEPPLYATVYVPAQKAAGIPAHA
                     SVDLTVQSVPSQEYGVLRGEVKKVDRSAQSPRQIAAFLGDTQLGEEFTRDGRPVAVTVK
                     LKRSSGTESGYAWSSADGPPFELTSMTLATGSIRLSDQRPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="DJ64_RS31860"
                     /old_locus_tag="DJ64_22145"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="DJ64_RS31860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_22145"
                     /product="hypothetical protein"
                     /protein_id="WP_033275279.1"
                     /sec_met_domain="strepbact (E-value: 1.6e-35, bitscore:
                     120.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETVEIADAELDAVSGGLSVNAVNTLTGALDGIAPVSGL
                     VDTVVGTVEGVTGLNTAPVTNLVAGL"
     misc_feature    5232..5245
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.44"
                     /tool="antismash"
     gene            5787..7163
                     /locus_tag="DJ64_RS31865"
                     /old_locus_tag="DJ64_22150"
     CDS             5787..7163
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117169.1"
                     /locus_tag="DJ64_RS31865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_22150"
                     /product="S1 family peptidase"
                     /protein_id="WP_033275278.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAVMAVGGVVALGAAAILLPNANASQDGASDGVTAA
                     PRTLKAGDASDLATRLAGTLGDAWAGAWYDGEDKQLVVNVVRGENTMALKVRSAGAEVR
                     WVDNSMAELEAGAGTLKSEATIPGTSWAVDPRTNKILVTADSTVTGDQWDQLESTVEDL
                     GSGMATLKKSAGTFRTFASGGDAIFAGGARCSLGFNVTAGDGSPAFLTAGHCAAAGDEW
                     SDQQGGRPIATVDQALFPGAGDFALVTYDDPATEAPSEVNVGGQTVPIVQAAEATVGQQ
                     VFRMGSTTGLADGQVLGLNATVNYPEGTVTGLIQTDVCAEPGDSGGSLFTQDGLAIGLT
                     SGGSGDCTVGGETFFQPVTTALEAVGATLGDGGAGAGDQAGGQEQGTGQEAGDGQAGAE
                     DQAGAGDQAGAGDQAGGQDAGAGQDAGAGQDAGGQDMQDGTGTGSGRHSGQDSGLSRTH
                     "
     gene            complement(7609..9750)
                     /locus_tag="DJ64_RS31870"
                     /old_locus_tag="DJ64_22155"
     CDS             complement(7609..9750)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995666.1"
                     /locus_tag="DJ64_RS31870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_22155"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_167338210.1"
                     /transl_table=11
                     /translation="MVGVSEGQASARSHAPVGRPLLSLTLAALMDEVHAHSGAVYLLSP
                     DQPVLEMAVMAGLPRAFAAPWERVGLSAPIPVSDAVRERRLVWVGGGEEMARRYPRIAM
                     VLPYPFCLAALPVATAAKTYGAVFVTWPGSHPPELSVRERERLTAACDRLAVRLERAAE
                     RSLPLAHEPDLLAAPVVGGAAGSLGTVEAARMVSRLPYGLCSLDLHGRVAFANAAASDL
                     LGVAPDQLSGAHLWAAVPWLNDPVYEDRYRAALLSQHVTSFVALRPPDTWLSFRLYPST
                     TGLSLRVSRARAVTEMNRAAPQPGAGRGRLVTITPVLGLAGALTEAVGVQDVVQLVADE
                     IVPAVGGQGLVVLGSRAGRLRVLGHRGYADPLVVERFDGLPLSEPTPGGQVLRTGVPAF
                     FESREELERLYPALQTHPSEFSAWAYLPLIASGRPVGTCVLSYGAPHRFATEERAVLTS
                     LAGLIAQALERAMLYDVKHRLAHGLQEALLPHTLPALEGIEAAARYLPATQGMEIGGDF
                     YDLVPVDGVAAAVIGDVQGHNVTAAGLMGQVRTAVRAYTAVGQAPDEVMRSTNRLLLDL
                     GAELFASCLYLRLDAARGRAVMSRAGHPPPLLRRPDGRVRVLDLAGGPLLGIDGTAAYP
                     STEVALPPGSLLVLYTDGLVESPGVDLEDALAELCRRLTELGDLPLDDLADALMRHGPH
                     SADRLDDTAVLLLRSLPRP"
     misc_feature    9717..9736
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.48"
                     /tool="antismash"
ORIGIN
        1 accgccgtca ggttcttgat ccgcccggcc ttctgctgga gctcacggct gcgcgcgaac
       61 tgcgacgccc acgccgcgta cgcgtagttc tccgccgccg ccacgcgcag cttcggcaga
      121 ccgcgcaggg tctggaacgc ctggttgttc agcttgttgg tgagcaccac cagccgtcgc
      181 tgccagcgca cctgccacag cccgagaccc aggaacacgg ccgcgatcac caccagcatg
      241 cccatcgcgg ccagcgccat cggcacgctg aaccacagca gcagcgccag gttcaccgcg
      301 cccaccgtga gcgactgcgt caccgtgggc ccgacaccgg ccagcatgcg gcggatcgcg
      361 ctgatgccca tcgccgcgct cgccagctcg cccgtggacc gctccgtgaa gaaccgggtc
      421 ggcagcctga gcagcctgtc ccacaccgcc ggctggagcg tggcctccac ccggccctcg
      481 agacgcagca gcgtgaggtt ctgcagcagc atgaacgcgg ccgcgaccac actgctgagg
      541 atcaccgcga gacacacctg cacgatcagg tccgtctgcg ccttcggcac gtactcgccg
      601 agcacccggc ccgtcgccag cggcaccagc gcccccagca ccaccgtcac cagaccgctc
      661 agcagcaacc ccgtcagatc gccccgggtg ccgcccatgc agaaccgcat cagccgcagc
      721 gggctcagcc gccgctcggg cagcggacgg tagaacatca ccgcgcgcgg ctcgaactcc
      781 tcggcgttcg ccttctccac cggggtctcc cggccggtcg acggatgcac ggccacgtag
      841 ccgccgcgcc gccacagcag cgccaccggc gcccccgaca gggcacggtg acccaccagc
      901 ggtcccacgt cgtcgcgcca ccaccggccc tccagccgca ccacccgggt gcgcagccgc
      961 gaggccagcg ccacctgctc caccgggtcc agccggtcgg cgccggtgcc ggactgcgcc
     1021 ggcgaggcca gcgtgatccc ggccgcccgc gccaccagct cgcaggccgc gtacgtggcg
     1081 tccgcgtccg cggccgtcgt tcgctgcccc gaccgcttgc cgatcgacgc gagcagcgtc
     1141 cggtcggcct gcgcccgcac cgcctcaccg gccgcgatgc cctgcgcggt gcgcgactcg
     1201 tgcgtctcct ccagctgctc gatccaccgg tccagcgtgg tcatcagccg gtactgctgg
     1261 tcgaccatgc tctgccacag cgccgggtcc atcagcaggt cggccgcggc ctccgcgccg
     1321 tacacggagc cgtactgcac gctgcccggg ggcacctgca tccagaacac gtcgtcgtcg
     1381 gtgggcgccg ccgcccgctc cgtcgccatc ggcgcctgga acagcacggc gaggctccgg
     1441 cccacgccca gcgcgagcgc gtactccagc gggctcgtcg tgggcggcac gtactgcggg
     1501 ttgccgtacg cgtcgtacga ccaggtctgg gtctgtgcct cctggtacag ctcgcgcagc
     1561 gcgatgcggt gcaccacgca gtcccgcagc ggccgcgcca ccagcgtgtg cgccggaccc
     1621 gccaccggac ccagcaccag cgaacccgcc tccagacggc ccaggtggtg ccagtgcccc
     1681 tgctgctccg cgtccaccgc gaacaggtcc acggcgccgg acgcgatcag ccacagcacc
     1741 tgcggcccct ccaggtccag cttcccgaac ccggagcagt cgatcggggt gcccagcgcg
     1801 ccgagcgcgc ccaggacgac gtcgccgccc tgcccctcgt gcacggcagt catctcatcg
     1861 ctccctgacc agcgccgcgt acgcgccgcc gcgcgccacc agctcctcgt gccgcccgcg
     1921 ctccacgacc gtgccctggt ccagcacgac gatctcgtcg ctgtcgcgga ccgtggacag
     1981 ccggtgcgcg atcaccacgc acgcgcagcc gcggcggcgc aggttgtcca tcaccaccag
     2041 ctccgtctcg gcgtccagcg cgctggtcac ctcgtcgagc accaggatgc tcggccggcg
     2101 caccagcgcc cgggcgatct ccagacgctg gcgctggccg ccggagaagt tccggccgtc
     2161 ctgctcgacc gggctgtgga tgccgcccgg acggcgcacg atcacgtcgt acagcgccgc
     2221 gtccttcagc gcctccacca ccgcctcgtc cgggatcgac gggtcccaca gcgccacgtt
     2281 gtcccgcacc gtcccctcga acaggaacac gtcctggtcg acgaaggaga cggacgccgc
     2341 cagcgccccg cgtgggatgt cctcgatgcg ctgcccgtcg atccggatga cgccctccca
     2401 cggggtgtag agccccgaga tcagccgtga cacggtcgac ttgccgctgc ccgagccgcc
     2461 caccagcgcc acctgctgcc ccggaccgac cgtcaggtcg aagccggtca gcagcggctt
     2521 gtccagcggg ttgtagccga aggtgaggtt ctgcagctcc acatggccgt gcagccgccg
     2581 ggtcgactca ccggcgcccg gacgcccgta cagcgggtcc gtccggaagt tctccacgtc
     2641 cttcagccgg gccacgtcgg cggcgaagtc ctggatgcgg cccgccaccc cgttcagccg
     2701 ggtcagcggg gccgtgaacc gggcgaccag cgcctggaag gccaccagca gaccgaccga
     2761 gatgtgcccc tcgaccgccc gcatgccgcc gatccagagg atcagcgcgc tgttcagcgt
     2821 ggccagcgtc ggcgcgacga cgccgagcca cgcgctcggc accccgagcc gctgctgctc
     2881 ctccagcgtg gtggcgtgct gcccggccca cttgcggaag tagccgtcct cgccgccggt
     2941 cgccttcagc gtctcgatca gctggagccc cgtgtacgcg gtgttggtga gccgcgccgt
     3001 gtccgcgcgc agcttcgccg tgcgggtggc gcgcagccgg atcacgatcc gcatcgcgag
     3061 gatgttcagc agcgccaccc cgatgcccac gaacgtgagc tgcgggtcgt acgtgtagag
     3121 cagcaccgcg tacagcacga ccacgaccgc gtccacgccc gccgccgaca ggtcacgggc
     3181 cagcgtctcg gccacggcgt cgttggactg caggcgctgc acgaggtcgg cggggctgcg
     3241 ctgggagaag aacgtcaccg gcagccgcag caggtggcgc aggaagcgcg cgctggacag
     3301 cgtcgacgag atcagccggc cgcgcagcag gttcgcctgc tggagccagg tcaggagcag
     3361 cgtcagcagg acgcacgcgc ccatcgacgc gaacagcacg tccagcatcg acgtctgctg
     3421 cccgatcagg aactcgtcga tgaaggtgcg gctcaggccg ggcagcgccg cgcccaccgc
     3481 caccagcagc agactggtca gcaccacggc gggcatcgtg cccgcggtgc cgcgcagccg
     3541 cgccggcatc gcgccgagca caccgggctt gcggccgccc cgggtgaagt cgtcgccggg
     3601 ctccatcacc agcaccacgc cggtgaagct gccgtcgaac tcctccagcg gcacgaacct
     3661 gcggcccttg gcggggtcgt tgacgtacac cccgcgacgg ccgaagcggc ggcccatgcc
     3721 gtcgtagacg acgtagtggt tgaactccca gaacaggatg gccggcgacg tcacctcggc
     3781 gagggcggcc aggtccatct gcatgccctt ggcggtcagc ccgtagctgc gggccgcctt
     3841 cagcaggttg ctggcgcgcg agccgtcccg cgagacgccg cacgcgatgc gcagctcctc
     3901 cagcgggaca tggcggccgt gatggcccag caccatggcc agcgaggcgg ccccgcactc
     3961 cacggcctcc atctggagca cggtgggcgt acggaccgtc ttcgcgcggg acttgggcac
     4021 cttacggcgg ggcggggcgg cgcggcgtct gccgcgggtc tcctgtgcgg tgctcacggc
     4081 agcagccaat ccacggggcg ctggtcggac agccggatgg aaccggtggc cagggtcatc
     4141 gacgtcagct cgaacggcgg gccgtcggcc gaggaccacg cgtagccgct ctccgtaccg
     4201 gacgagcgct tgagcttcac ggtgaccgcc acgggcctgc cgtcgcgggt gaactcctcg
     4261 ccgagctggg tgtcgccgag gaacgcggcg atctggcgcg gggactgggc ggagcggtcc
     4321 accttcttca cctcgccgcg cagcacgccg tactcctggc tcggcaccga ctgcaccgtc
     4381 aggtcgacgg aggcgtgcgc ggggatgccg gcggccttct gcgcggggac gtacaccgtg
     4441 gcgtacaagg ggggttcgtc gccgcggacc ttctcgacgg cggcgacgtc cgcgccggtc
     4501 gagatgatct gcccggcgct ggcggcgagc gcggtgatcc ggcccgcctg aagcgtgcgc
     4561 acgacctggt cgccgtccgg tgtacggacc ttgagcacgg gggagttcgc cggcagccgc
     4621 tcgccctcgc gcgcgagtac ggcggtgacc tgaccggcga cggggctctg caggatgtaa
     4681 ctgccctgcc cgtacgtgag gatggcgggc gcctgcaccg tggaggtgac cgagccggtc
     4741 agcgcccaca cggacgcggc ggccatcgcg atcacggtga cggacagcac cagccagccc
     4801 tgcgggcggg cgaaccgcac cgggaggtcg agatcctccg gcgactggag cttggcgagg
     4861 gcctgttggc ggaattgcac gggtcttccc tcacctgggt gaactgtgcg acgtgacgga
     4921 aggactggaa ggaccgcgaa cgcaccacag agccccggag ccggggtacg gctccgggac
     4981 tcggtggaac aagggcgcga tcagagaccg gcgaccaggt tggtgaccgg ggccgtgttc
     5041 aggccggtga caccctcgac ggtgccgaca acggtgtcga ccaggccgga aaccggggcg
     5101 atgccgtcca gggcgccggt gagggtgttc acggcgttga cggacagacc accggaaacg
     5161 gcgtcgagct cggcgtcggc gatctcgacg gtctcgacct ggggggtgga gttcatgatg
     5221 gaacttccct tcgtatggac tttcacaagg ggggagcggc ccccctctgg ggacagatga
     5281 aggccgcgac cgcgggcgct ccgagcgccc gtcgccggga gcccggaacg gccttgcggt
     5341 gcgatggatc aaagcacgcg gcaaccggcc gcttccaatt cctcacccgc ctcaccaggc
     5401 aacttgcgcc caggcggcac ccaagcgtgc agacgagggc acggctcggc ggcgacttct
     5461 tcacatgggc cacggcatgt acccatccgg ccacttgcgg cccgtggccg gaaagcgaca
     5521 caccggccgc aatgacgtgt cccggatagg tgccctctgc atgtgtcatg ggtccggtga
     5581 ccgggttggg cattcgctgt gcagattcgc cgaagccggg attcaagacc cgagcggaca
     5641 cccggtgtgc ctgcccggtg gcggaacgtg agcgcccgga aaggcgttga acactcctca
     5701 actcccttgc gtaccaacga ccgtccaggc gccgaaccgc cgccggagag cggcacgact
     5761 ccggtccccc caggaggtcg agaagtttga gtcacaagcg aatcccgaag cgcaaggccg
     5821 tgatggcggt gggaggtgtg gtggccctcg gcgccgccgc gatcctgctc cccaacgcca
     5881 acgcgtccca ggacggcgcg tcggacggcg tcacggccgc gccgaggaca ctgaaggcgg
     5941 gcgacgcatc ggacctcgcc acccggctcg ccggcacgct cggcgacgcc tgggcgggcg
     6001 cctggtacga cggcgaggac aagcaactcg tcgtcaacgt ggtacgcggc gagaacacca
     6061 tggccctgaa ggtccgcagc gcgggcgcgg aggtccgctg ggtcgacaac agcatggccg
     6121 aactcgaggc cggggcaggc acgttgaagt cggaggcgac catcccgggc acctcctggg
     6181 cggtcgaccc gcgcaccaac aagatcctcg tcaccgcgga cagcacggtc accggcgacc
     6241 agtgggacca gctggagtcc accgtcgagg acctcggctc cggcatggcc accctcaaga
     6301 agtccgcggg caccttccgt accttcgcgt ccggcggcga cgccatcttc gcgggcgggg
     6361 cgcgctgttc gctcggcttc aacgtcaccg cgggcgacgg cagcccggcg ttcctcaccg
     6421 ccggacactg cgccgccgcc ggcgacgagt ggtccgacca acagggtggc cggcccatcg
     6481 ccacggtcga ccaggcgctg ttccccggcg cgggcgactt cgcgctcgtc acctacgacg
     6541 acccggccac cgaggccccg agcgaggtga acgtcggcgg ccagacggtc ccgatcgtcc
     6601 aggccgccga ggccaccgtc ggccagcagg tgttccgcat gggcagcacc accggcctcg
     6661 ccgacggcca ggtgctcggc ctgaacgcca ccgtgaacta ccccgagggc acggtgaccg
     6721 gcctcatcca gaccgacgtg tgcgcggagc ccggggacag cggcggctcc ctcttcaccc
     6781 aggacggtct ggccatcggc ctgacctccg gcggcagcgg cgactgcacg gtgggcggcg
     6841 agacgttctt ccagcccgtc accaccgccc tcgaggccgt cggcgcgacc ctcggcgacg
     6901 gcggtgcggg cgccggggac caggcgggcg gccaggagca gggcacgggc caggaggccg
     6961 gcgacggcca ggccggcgcg gaggaccagg cgggcgccgg ggaccaggcc ggagccgggg
     7021 accaggcggg cggccaggac gccggcgccg gccaggacgc gggcgccggg caggacgcgg
     7081 gcggacagga catgcaggac gggaccggta ccggttccgg ccgtcactcc ggtcaggact
     7141 ccggactgtc ccggacgcac tgacccgcgc gcgccaccac cgtgtgcgtg aggcgccccc
     7201 ggccgtgtgc gggccggggg cgcgcccctg ccgcgggcag tcgtgccgct tggggcgatg
     7261 gggggagggt gggcgcagtg gcacccttca gcgccgggtg cgggtcgtcc gtggctggtc
     7321 gcgcagttcc ccgcgcccct gaggtgtgct tccgccacgg ccgttggaag cgccctgttg
     7381 tcgctggggg ccggccctct cccgcgccgg gtgcgggtcg tccgtggctg gtcgcgcagt
     7441 tccccgcgcc cctgaggcgt gcttccgcca gggccgttgg aagcgccccg tcgggggtat
     7501 ctcccgctcg agcgaagccg ggagtcggga agggtgggcg gcgcagcggc accctgtcag
     7561 cgtcgggtgc gggtcgtccg tggctggtcg cgcagttccc cgcgtccctc aggggcgcgg
     7621 cagggacctc agcagcagca ccgccgtgtc gtccagccgg tccgccgagt gcgggccgtg
     7681 ccgcatcagc gcgtccgcca ggtcgtccag cggcaggtca ccgagctcgg tgagcctgcg
     7741 gcacagctcg gcgagggcgt cctccaggtc gacgcccggc gactccacca ggccgtccgt
     7801 gtacaggacg agcagcgatc cgggcggaag cgccacctcc gtcgacggat aggccgccgt
     7861 gccgtcgatg cccagcagcg gcccaccggc caggtccagg acccgcaccc tcccgtcggg
     7921 gcggcgcagc agcggcggcg gatgccccgc ccgcgacatc acggcccgcc cccgcgccgc
     7981 gtcgagccgc aggtacagac agctcgcgaa cagctccgcg cccaggtcca gcagcagccg
     8041 gttggtgctg cgcatcacct cgtccggcgc ctgacccacc gccgtgtacg cccgcaccgc
     8101 cgtacggacc tggcccatca gcccggccgc cgtcacgttg tgtccctgca cgtccccgat
     8161 caccgccgcc gccaccccgt cgaccggcac caggtcgtag aagtcgccgc cgatctccat
     8221 gccctgggtg gcgggcaggt accgggcggc ggcctcgatg ccctccagcg ccggcagggt
     8281 gtgcggcagc agcgcctcct gcagtccgtg cgccagccgg tgcttcacgt cgtagagcat
     8341 cgcccgctcc agcgcttggg cgatcagccc cgccagactc gtcagcaccg cccgctcctc
     8401 cgtcgcgaac cggtgcggcg ccccgtacga cagcacgcac gtccccaccg ggcggcccga
     8461 ggcgatcagc ggcaggtacg cccacgccga gaactccgac ggatgcgtct gcagcgccgg
     8521 gtacagccgc tccagctcct cccgcgactc gaagaaggcg ggcaccccgg tccgcagcac
     8581 ctgaccgccc ggcgtcggct cggacagcgg cagtccgtcg aaccgctcca ccaccagcgg
     8641 gtccgcgtac ccgcggtgcc cgagcacgcg cagccggccc gcacgggacc cgaggaccac
     8701 cagcccctgg ccacccaccg ccggcacgat ctcgtcggcg accagctgca ccacgtcctg
     8761 caccccgacc gcctcggtca gcgccccggc caggccgagc accggggtga tggtcaccag
     8821 ccggcccctg cccgcacccg gctgcggcgc cgcgcggttc atctccgtca ccgcgcgggc
     8881 cctgctgacc cgcaggctga gaccggtggt gctcgggtac agccggaagg acagccacgt
     8941 gtcgggcggc cgcagcgcca cgaacgacgt gacgtgctgg ctgagcagcg ccgcccggta
     9001 ccggtcctcg tacaccgggt cgttcagcca cggcaccgcc gcccacagat gcgcgccgga
     9061 gagctggtcc ggcgccacgc cgagcaggtc ggacgcggcg gcgttggcga acgcgacccg
     9121 tccgtgcagg tccagcgagc acagcccgta cggcagccgg gacaccatcc gggccgcctc
     9181 caccgtgccc agcgagccgg ccgccccgcc caccaccggc gcggccagca ggtccggctc
     9241 gtgcgcgagg ggcaggctgc gctcggcggc ccgctccagc cgcaccgcca gccggtcgca
     9301 ggcggcggtg agacgctcgc gttcccggac cgacagctcc ggagggtggg agcccggcca
     9361 ggtgacgaag accgcgccgt acgtcttcgc cgccgtcgcc accgggagcg cggccaggca
     9421 gaaggggtag gggaggacca tggcgatccg ggggtagcga cgggccatct cctccccgcc
     9481 gcccacccac accagccggc gttcgcgcac cgcgtcggag accgggatcg gcgcgctcag
     9541 cccgacccgc tcccacggcg cggcgaaggc gcggggcagc cccgccatca cggccatctc
     9601 cagcacgggc tggtcggggg agaggaggta gacggcaccg gagtgggcgt gcacctcgtc
     9661 catcagggcg gccagcgtga gcgacagcag gggacggccc acgggggcgt gcgaccgcgc
     9721 ggacgcctgt ccctcggaca cgccgaccac ctcctcgcac ggcccgcacc caatctcccc
     9781 tgcgacaggg cgtcccgcac gacgagcggg acgcgccggg cgcgcgcatc tgtgcggata
     9841 ccccattgcg gcgcggcaag acggaatcag cccctccggt gcttgaggag cgcggtccgg
     9901 ggcggagccc cgcggaggtc cgggcggccc ggaccgcgcg cggtcgcgga cacgtgaacc
     9961 gagagccggg cgcctccccg tgagaagagc ggcgcggctc tgccgcgtgc cgttcgcgca
    10021 caggggctgc gtttgtgtcc ctttagcgct gtaatggcca acgtggtcgg tgagggcgct
    10081 gcgggacgca gcacgagaac gctgcgcgcc gaaggcgcac tgagcgcgct cgcggccggc
    10141 ccccacgcga ccgaccggct gcgccgcgtc ctggaacagg ccctcgtgtt cgcgggggcg
    10201 gccttcgccg gcttct
//
