LOCUS       NZ_KL503830            22494 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Streptomyces griseorubens strain JSD-1 scaffold1, whole genome
            shotgun sequence.
ACCESSION   NZ_KL503830
VERSION     NZ_KL503830.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces griseorubens
  ORGANISM  Streptomyces griseorubens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces althioticus group.
REFERENCE   1  (bases 1 to 7563100)
  AUTHORS   Feng,H., Zhi,Y., Sun,Y., Wei,X., Luo,Y. and Zhou,P.
  TITLE     Draft Genome Sequence of a Novel Streptomyces griseorubens Strain,
            JSD-1, Active in Carbon and Nitrogen Recycling
  JOURNAL   Genome Announc 2 (4), e00650-14 (2014)
   PUBMED   24994798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7563100)
  AUTHORS   Feng,H., Sun,Y., Zhi,Y., Mao,L., Luo,Y., Wei,X. and Zhou,P.
  CONSRTM   Shanghai Jiao Tong University
  TITLE     Draft genome sequence of the novel Streptomyces griseorubens JSD-1
            playing a role in carbon and nitrogen cycle
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7563100)
  AUTHORS   Feng,H., Sun,Y., Zhi,Y., Mao,L., Luo,Y., Wei,X. and Zhou,P.
  CONSRTM   Shanghai Jiao Tong University
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2014) School of Agriculture and Biology, Shanghai
            Jiao Tong University, Shanghai Jiao Tong University, Shanghai,
            China, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2013-12-24
            Genome Coverage                   :: 246x
            Sequencing Technology             :: Illumina Miseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000709915.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 03:19:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,036
            CDSs (total)                      :: 6,948
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 329
            CDSs (without protein)            :: 328
            Pseudo Genes (ambiguous residues) :: 0 of 329
            Pseudo Genes (frameshifted)       :: 72 of 329
            Pseudo Genes (incomplete)         :: 272 of 329
            Pseudo Genes (internal stop)      :: 8 of 329
            Pseudo Genes (multiple problems)  :: 23 of 329
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4116132
            Orig. end                         :: 4138626
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KL503830.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22494
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="10"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22494
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22494
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12494](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12494
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(327..342)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.51"
                     /tool="antismash"
     misc_feature    complement(621..635)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     misc_feature    complement(631..648)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     assembly_gap    1663..1762
                     /estimated_length=100
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <1763..2306
                     /locus_tag="DJ64_RS38185"
                     /pseudo=""
     CDS             <1765..2306
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527426.1"
                     /locus_tag="DJ64_RS38185"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="dTMP kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RTAATPSEAPARPASGQDADEALTVPTPVVTPTNATGGPVDETAV
                     LPRVRDEEAARDADRPAPADAEVTTELPRPQVPGAADETAVLPPVPPGAADETAVLPPV
                     REDGPGPAGGAEEPEDRTRELPQVDAGNAPRRRERPDWAEETPLDDLPSLADELLGPHE
                     DDHGDDDGRGGGRWRRR"
     gene            2454..3659
                     /locus_tag="DJ64_RS18715"
                     /old_locus_tag="DJ64_06710"
     CDS             2454..3659
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674051.1"
                     /locus_tag="DJ64_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06710"
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="WP_033274893.1"
                     /transl_table=11
                     /translation="MTVWDDLVGQERVSEQLAAAARDADAFVTAAASDAPPPEASRMTH
                     AWLFTGPPGAGRNQAARAFAAALQCVSPDRALGGAPGCGFCDGCHTALVGTHADVSTVA
                     AVGAEILVKDMRDTVRKSFTAPANGRWQVILVEDAERLNEKSANAVLKAVEEPAPRTVW
                     LLCAPSVEDVLPTIRSRCRHLVLSTPSVEAVADMLVRREGIEPDVAASVARATQGHVDR
                     ARRLATDPAARARRATVLKLPQRVEDVGGALRAAQELVDAAAEDAKQLAEEMDGKETED
                     LKAALGAAQGGRLPRGTAGVVKDLEDMQKRRRTRTQRDSLDVALADLTSFYRDVLALQL
                     GSRIALANTDAEDALERLARSSTPESTLRRIEAIAACGEALDRNVAPLLAVEAMTMALR
                     AG"
     gene            3767..5356
                     /locus_tag="DJ64_RS18720"
                     /old_locus_tag="DJ64_06715"
     CDS             3767..5356
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (114-501). E-value:
                     7.7e-24. Score: 76.6. Matches aSDomain:
                     nrpspksdomains_DJ64_RS18720_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975395.1"
                     /locus_tag="DJ64_RS18720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06715"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_033274894.1"
                     /sec_met_domain="PF00561 (E-value: 2.6e-34, bitscore:
                     117.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTRRTPRRTRTAAALFTAAALLSAGCSSGTSTNTTASSPVAGAA
                     AALAPLPGSTPAALAEYYAQEPAWRDCGVPGFQCATVKAPLDYAEPSAGDVRLAVARKK
                     ATGPGKRLGSLLVNPGGPGGSAVDYLQMYAGIGYPEEVRARYDMVAVDPRGVARSEPVE
                     CLDGRAMDAYTRTDTTPDDEKETETLVSAYRTFAEGCGAKAPKLLRHVSTVEAARDMDV
                     VRAVLGDEKLSYVGASYGTLLGATYAGLFPERTGRLVLDGAMDPSLSARRLNLEQTEGF
                     ATAFTAFAKDCVRRSDCPLGGKGTSPEKVGENLKAFFEKLDARPLPAGDADGRELTESL
                     ATMGVIAAMYDEAAWQRLREALTSAMKENDGAGLLVLSDSYYERDAGGAYSNLMSANAA
                     VNCLDLPPAFETPEQVREALPDFEKASPVFGEGLAWAALNCAYWPVRATGEAQRIEAKG
                     AAPIVVVGTTRDPATPYRWAEGLAGQLSSARLLTYDGDGHTAYGRGSSCVDSAINTYLI
                     EGTPPADGKRCS"
     aSDomain        4109..5269
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DJ64_RS18720_Abhydrolase_1.1"
                     /evalue="7.70E-24"
                     /label="DJ64_RS18720_Abhydrolase_1.1"
                     /locus_tag="DJ64_RS18720"
                     /protein_end="501"
                     /protein_start="114"
                     /score="76.6"
                     /tool="antismash"
                     /translation="LLVNPGGPGGSAVDYLQMYAGIGYPEEVRARYDMVAVDPRGVARS
                     EPVECLDGRAMDAYTRTDTTPDDEKETETLVSAYRTFAEGCGAKAPKLLRHVSTVEAAR
                     DMDVVRAVLGDEKLSYVGASYGTLLGATYAGLFPERTGRLVLDGAMDPSLSARRLNLEQ
                     TEGFATAFTAFAKDCVRRSDCPLGGKGTSPEKVGENLKAFFEKLDARPLPAGDADGREL
                     TESLATMGVIAAMYDEAAWQRLREALTSAMKENDGAGLLVLSDSYYERDAGGAYSNLMS
                     ANAAVNCLDLPPAFETPEQVREALPDFEKASPVFGEGLAWAALNCAYWPVRATGEAQRI
                     EAKGAAPIVVVGTTRDPATPYRWAEGLAGQLSSARLLTYDGDGHTAY"
     tRNA            5476..5549
                     /anticodon=(pos:4121642..4121644,aa:Thr,seq:cgt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="DJ64_RS18725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="DJ64_06720"
                     /product="tRNA-Thr"
     gene            5476..5549
                     /locus_tag="DJ64_RS18725"
                     /old_locus_tag="DJ64_06720"
     gene            complement(5606..6307)
                     /locus_tag="DJ64_RS18730"
                     /old_locus_tag="DJ64_06725"
     CDS             complement(5606..6307)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="DJ64_RS18730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06725"
                     /product="response regulator transcription factor"
                     /protein_id="WP_037643993.1"
                     /transl_table=11
                     /translation="MTVNLFVVSDNPVSLAGLEAIVDQDKECALVGRATDDSDDLRCLS
                     DLAGTALHPDVVVLSEPCSSRTVSAHVRHIASAFPDEASRPHTIVVAQNDDDQMIVSAL
                     RAGVNGYLSRLGSADELLRSLKVVARGGAAFCPSVAARMSRYFSAMQGLNDSVGFPGLT
                     SRELEILELLAGGMGNRQIARRLFLAEKTVRNYVSRIFTKLEVHDRATAVVMARDAGFG
                     EPAGELVRNSA"
     misc_feature    complement(6696..6710)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            6788..7927
                     /locus_tag="DJ64_RS18735"
                     /old_locus_tag="DJ64_06730"
     CDS             6788..7927
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958865.1"
                     /locus_tag="DJ64_RS18735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06730"
                     /product="sensor histidine kinase"
                     /protein_id="WP_078492943.1"
                     /transl_table=11
                     /translation="MGEGSRRRAIVLDGAAACVFTLLPQVSLLRPAVDGGTGGGVLWLL
                     SLGAGLPLVVRRLWPVPVFVLVLAAACGALAAGLGPAAFLAAAYAVYTVATTRRRDPGV
                     SAVAVAGLCAAVAALLTLSGGQSYQGGSTAVQAVFGLLVLGATWAAGSAVRERRRSTRR
                     AIEHAAEQAKTEERLRIARDLHDVVTHSVGLIAVKAGIANHVVATRPEEAKEALAVIED
                     VSRRALRDMRATLTVLRGEDRSDAGDLRPARGLADLPALLGTAEAAGVRVELRTRYDQE
                     PPEGVALAAFRIVQEALTNVVKHAAPTGCRVDVTAREGVLTVEVTDDGPAPGRRTTVPG
                     GGMGLVGMKERTAAHGGTLRAGPRPGGGFRVTATLPFQV"
     gene            8046..8948
                     /locus_tag="DJ64_RS18740"
                     /old_locus_tag="DJ64_06735"
     CDS             8046..8948
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173620.1"
                     /locus_tag="DJ64_RS18740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06735"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_037643995.1"
                     /transl_table=11
                     /translation="MLAERLTKRYGPATVVDDLSFTVRPGVVTGFLGPNGAGKSTTMRM
                     MLGLTRPDSGTATVGVRPYRDLTYPLRHVGALLETSAPHRGMTAVGHLSWLARSNRIPR
                     RRVDEMLDAVGLTGAARQRVGTFSLGMGQRLGLAAALLGDPPVLVLDEPVNGLDAEGIR
                     WLRELLRAKAAEGRTVLVSSHLMAEMAQVADELIVISRGRLLAETSVSEFIGRHGRTFV
                     RVRTPEPLRAAQEFQAQGAASVRRAADGGLEVDGLPAGEVNRIAAAAGVPVEELSTHTG
                     SLEETFLKLVDDGGDPTHV"
     gene            8941..9693
                     /locus_tag="DJ64_RS18745"
                     /old_locus_tag="DJ64_06740"
     CDS             8941..9693
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="DJ64_RS18745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06740"
                     /product="ABC transporter permease"
                     /protein_id="WP_037640853.1"
                     /transl_table=11
                     /translation="MSETLAAARAEFTKMRAVRATSVALLLFVAVSVFIAALGGWSAKG
                     AIESDNPGLRSDFTPEQAGLDGILYGQLALIVFGVLMMSGEYTSGTMRVSLLAVPRRGR
                     LYLAKTAVTAAAALAVALPVTVVSYLVTQLALGPHGSTLDADGVPRALAGGVVYLTLMS
                     LLAVGVAAAARSAVLPLAVLLPLVLVGSQILSVIGATKEVARWFPDRAGAQMLTVDSGD
                     ALTGLVVLLAWTAAALTAGWVRHRSWDG"
     gene            9810..9938
                     /locus_tag="DJ64_RS36290"
     CDS             9810..9938
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_103079659.1"
                     /locus_tag="DJ64_RS36290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aborycin family tricyclic lasso peptide"
                     /protein_id="WP_106963308.1"
                     /transl_table=11
                     /translation="MTAIYEPPALQEIGDFDELTKCLGIGSCNDFAGCGYAVVCFW"
     gene            10001..11812
                     /locus_tag="DJ64_RS18750"
                     /old_locus_tag="DJ64_06750"
     CDS             10001..11812
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_067372303.1"
                     /locus_tag="DJ64_RS18750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06750"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_037640855.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.2e-37, bitscore:
                     128.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTVLPDCPAGAALADRVAAPKRIDHASGRPWIVGDWAVGEATV
                     TEAGIRRLAVFGHTRPDDAGTVSALGRMRSLHDVDRVASRLPGVFHLVASLDGAVRLQG
                     SVAGVRQVFTTRVDGVTVAASAVDPLLRLTGAGLDETLLAARLLAPGGAPWPLSLRPVR
                     RGVDALPTGHWLELGADGRARSVRWWELPEATLSLEEGAGAVRSALTDALATRVAPDRT
                     ISADLSGGLDSTTLCFLADAAGADLVTYHVMPLDEANEDTAWARKAAAHLPHARHHMLA
                     ADRAANLFDVGYTADTADAAPEGPSTWASGLAHIRDLAGRATAEGAALHLSGFGGDELF
                     GRMPACAWSLARIRPADGLRLVNRYRLANRWPWRSTLRQLADRSTFAQNLIEVAGRITA
                     PPPPVNEPDFGWVFAPRMPAWATPDAVATVRDLLTTAAERTPEPLDADRARHQALSSVV
                     FEGNTVRQVNTAVAGTGLVWEAPFLDDRVLEAAFATRIDERLAAGRFKPLLTTAVRGLV
                     PDDFLARRDKGEFSAETFRGIERNRDRILDLCEDSLLARLGLVDPVAFRSAVLNPGPMS
                     HHLQPIQTTVACESWLRAHPQDSGENR"
     aSDomain        11809..11979
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DJ64_RS18755_Lasso_Fused_RRE.1"
                     /evalue="4.50E-09"
                     /identifier="RREFam003.1"
                     /label="DJ64_RS18755"
                     /locus_tag="DJ64_RS18755"
                     /protein_end="57"
                     /protein_start="0"
                     /score="27.3"
                     /tool="antismash"
                     /translation="MKLSLARDVTLTPVDSGAVLLDGRRGRYYQLNASGSAILHKLLDG
                     DTPAAAAASLSE"
     gene            11809..12072
                     /locus_tag="DJ64_RS18755"
                     /old_locus_tag="DJ64_06755"
     CDS             11809..12072
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="DJ64_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06755"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_037640857.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.1e-06,
                     bitscore: 27.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.1e-22,
                     bitscore: 76.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.8e-12, bitscore: 44.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLSLARDVTLTPVDSGAVLLDGRRGRYYQLNASGSAILHKLLDG
                     DTPAAAAASLSESAPVSEERVHQDVLALVRSLSEADLVEVTQ"
     aSDomain        11815..12063
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DJ64_RS18755_Stand_Alone_Lasso_RRE.1"
                     /evalue="2.10E-24"
                     /identifier="RREFam002.1"
                     /label="DJ64_RS18755"
                     /locus_tag="DJ64_RS18755"
                     /protein_end="85"
                     /protein_start="2"
                     /score="76.4"
                     /tool="antismash"
                     /translation="LSLARDVTLTPVDSGAVLLDGRRGRYYQLNASGSAILHKLLDGDT
                     PAAAAASLSESAPVSEERVHQDVLALVRSLSEADLVEV"
     gene            12069..12494
                     /locus_tag="DJ64_RS18760"
                     /old_locus_tag="DJ64_06760"
     CDS             12069..12494
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123203.1"
                     /locus_tag="DJ64_RS18760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06760"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_037640859.1"
                     /sec_met_domain="PF13471 (E-value: 9.5e-25, bitscore: 85.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPAVAEQATRLPLHRQIAPRCAAGAARLLVGLPPARLHRVLRV
                     LSKGSRPAGYAQVARARRSVVSVSTRCAGLGCLQRSVATVLLLRVRGRWADWCTGFRVQ
                     PFAAHAWVEADGRPVDEPGEVGVFRTVLAVRRTGGGS"
     gene            12491..13456
                     /locus_tag="DJ64_RS18765"
                     /old_locus_tag="DJ64_06765"
     CDS             12491..13456
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385816.1"
                     /locus_tag="DJ64_RS18765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06765"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_037640860.1"
                     /transl_table=11
                     /translation="MTAIRAEGLYAYYGTTPAVNGLDLTVPEGATFGFLGPNGAGKTTT
                     ISMLTTLLRPTAGRAEVAGFDVTTHAAEVRRRIGIVFQESTLDLELTATENLRFQADLC
                     GLGRAEARAAVAAMLDMMELTGRDRTPVRHFSTGLRRRLEIARGLLGSPRVLFLDEPTT
                     GLDTQTRAAVWHHLDRLREEQGITVFFTTHQLEEAEHCDRIAIFDSGKLVTEGSPAELK
                     SVIGADVVDLRTEDDRLAVDLLSDRFGLTAESVPGGLRLRVQDGASTVPRLCTGLGLTV
                     RSVTVTPPSLDDVYLHHTGTAIRDSGSDARSLDSLGEGLR"
     gene            13453..14322
                     /locus_tag="DJ64_RS18770"
                     /old_locus_tag="DJ64_06770"
     CDS             13453..14322
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123205.1"
                     /locus_tag="DJ64_RS18770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06770"
                     /product="ABC transporter permease"
                     /protein_id="WP_037640862.1"
                     /transl_table=11
                     /translation="MTRTDIPPSVTLTKPAPSSSEARTWHTVRPYALLWRREMTRLRHN
                     PLRLVMGLVTPLLFLVVLGTGLEAASSTLGKAQLNDYRAYLFPGALVMSVQAPAIAVGI
                     SLVWDRRLGMLRQMLVSPFPRSSIVLGLALGGATTGAVYGLALLAVGGIAGVRYTPMLL
                     VVLVELLLVSLLFTSFGLLAAVTIRQVDTFQIVVNLSLMPLMFFSGAMFPPNGLPGWLD
                     TVVKLNPLTYGVDAVRRTLPGPDVLTSEQTRLMLGDWNPPVYAELGVLAALTAAVLSLA
                     TYRFSRTQ"
     gene            14336..14809
                     /locus_tag="DJ64_RS18775"
                     /old_locus_tag="DJ64_06775"
     CDS             14336..14809
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="DJ64_RS18775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06775"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_078492945.1"
                     /transl_table=11
                     /translation="MTFVRTWAGTAARIVLAAVLGYAGWVKVQDLTEAGRTVALYQFVP
                     EESAQLVGAAVAFVELALALLLLAGLATRAVAAVTALLMVTYIAAIASVWARGMSIDCG
                     CFSSGGTLTGGAERGYVVDIARDLAFLGAAAFLITRPRTRYALDRWVLETKER"
     gene            14812..15537
                     /locus_tag="DJ64_RS18780"
                     /old_locus_tag="DJ64_06780"
     CDS             14812..15537
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024853.4"
                     /locus_tag="DJ64_RS18780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06780"
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_037640865.1"
                     /transl_table=11
                     /translation="MQPSTDAQVREMVHRRRRRRRTVLVSLAAVVTVLGAALVGAGLVR
                     ATNTEPGEAPEEVPAGVAADRAGLVTSEGPVRVDLYLDYLCPECRITEKALEPKLRKMQ
                     ERGEVRVVHHPVAFLDDRSAPAGYSTRAASAAACAADQNKFQPYTAALFDEQPPEQGPG
                     LDTDRLVALGRDVGITGASFERCVRDGTYRPWVTYVSDVAASRGVALTPTVKVAGKRVE
                     LSGPDRAKAFVRAVEESRS"
     gene            15534..16856
                     /gene="mslH"
                     /locus_tag="DJ64_RS18785"
                     /old_locus_tag="DJ64_06785"
     CDS             15534..16856
                     /codon_start=1
                     /gene="mslH"
                     /inference="COORDINATES: protein motif:HMM:NF038314.1"
                     /locus_tag="DJ64_RS18785"
                     /note="Involved in the biosynthesis of MS-271 and related
                     lasso peptides; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06785"
                     /product="lasso peptide C-terminal Trp epimerase"
                     /protein_id="WP_037640867.1"
                     /transl_table=11
                     /translation="MSRLTVALTGDCMTTRGAPLTSDPAAGRLGEVLHTADFAFTNLEV
                     APATGRGHPVPDAASGGGLIADPAVLDDVTAMGFSALSCANNHALDLGTEGVLGTADLL
                     RAKGVPFAGIGADLTAARRPVYVDRPAGSLALIACTATFRDGQEAAVPSPDLPGRPGVN
                     PLRHGVTLRVTAAQLEALREIDGVTGLRSRRAEARTLLGFDPAMPGPGRLALFGTRFET
                     ADTPGLTTACDPRDVHDITRWVAEARRRADLVLVSVHSHEPGPTPETPAEFLRDFARAV
                     IDAGADAVVGHGPHMLRGAELHRGRPVFHSLGNIVSQIELADRVPAEDYARAGTDEALT
                     PGAYFERITAHGRRMFAPHRRYWQSLVPVLTFDDGVFTGARLHPVDLGFGQPVHRRGRP
                     RLAGPVDAKEILTDFARLAEPYGVTVTVGDDGTGELVAAET"
     gene            16956..17633
                     /locus_tag="DJ64_RS18790"
                     /old_locus_tag="DJ64_06790"
     CDS             16956..17633
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123207.1"
                     /locus_tag="DJ64_RS18790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06790"
                     /product="response regulator transcription factor"
                     /protein_id="WP_033274901.1"
                     /transl_table=11
                     /translation="MAEAVRVLIADDQALLRGSFRVLVDSTPGMETVGEAGDGAEAVAL
                     ARELTPDVVLMDLRMPVMDGIAATREICSDAALAGVRVLALTMFDMDEYVYPALQAGAS
                     GFMLKDASPDDLVTGIRVIATGEGVLAPSVTRRVIANFSHQDTAARPAPRLVGLTRREQ
                     EVLVLIAKGLSNAEIADHLVISLPTVKTHVSSLLSKLNARDRAQLVIVAYESGIAERGM
                     PPA"
     misc_feature    complement(16957..16971)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(17835..18977)
                     /locus_tag="DJ64_RS38775"
     CDS             complement(17835..18977)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.4"
                     /locus_tag="DJ64_RS38775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_342669083.1"
                     /transl_table=11
                     /translation="MLAVGGTAAWWNWRTDGDDPFDIPPAVAAPKARALDAAKGDYVLG
                     EAPEPLWQAPSALSDRPAAPLPVRDVLVVAAAKGGIAAHSVVDGSVRWSAPDVEATGRY
                     LSLSDRLVAAVDREGTLVTFVASTGEPKWTAPARAASLLDADAEAVYLITEDGRIRAVN
                     RSDATVRWTVPIDADLGEKAASRGLAARRRLVVTAADGSVAALDTADGRQVWQHRSLTD
                     SGRADADRSGGTLCVAGRQLAAYDLADGKELWSTETPDQPSGDPAFWSSPTVDGRTVYA
                     TEVVFPVRLDLRTGRPTDWIHTGLLQCDAGSPLVLQGSGLWSVATDGEQAAVQALDLSQ
                     EQRPTWTFPVLRNRDRYWITGDANRVFLVDGTSLSALPVF"
     misc_feature    19150..19165
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.6"
                     /tool="antismash"
     misc_feature    19151..19165
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.56"
                     /tool="antismash"
     gene            complement(19208..19519)
                     /locus_tag="DJ64_RS38780"
     CDS             complement(19208..19519)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="DJ64_RS38780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_342669084.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-11, bitscore: 43.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPANIVLTSTGPRVIDFGIARPEHGLTLTTTGQAPVTPGYGAPE
                     QVLGRRVGPPADVFSLGAVLVYAASGLHAYEGAHVAAVQYEVVHGAPAWTGYPPLSGR"
     gene            complement(<19569..19928)
                     /locus_tag="DJ64_RS38785"
                     /pseudo=""
     CDS             complement(<19569..19928)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="DJ64_RS38785"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="protein kinase"
                     /pseudo=""
                     /sec_met_domain="Pkinase (E-value: 2.7e-10, bitscore: 38.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLESGDPIRLGPYRVHGVLGEGGMGKVYVGRDGEGRVAAVKVL
                     HPHLAHDAGLARRFVREAQMARAVTSATVARVLDARTEDGRPWIATEFLAGPTLADVVG
                     SHGPLDEPTVRALAAG"
     gene            complement(19952..21934)
                     /locus_tag="DJ64_RS18800"
                     /old_locus_tag="DJ64_06800"
     CDS             complement(19952..21934)
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675371.1"
                     /locus_tag="DJ64_RS18800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_06800"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_051747660.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-27, bitscore: 95.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHGARVFDADPQADTPWLATEYVIGPPLDDAVALAGPLPEPTVRG
                     LGALLCAALGQLHASEVVHRDLKPSNIMITADGPKVIDFGIARALGDDRLTRTGMAAGT
                     PAFMSPEQATGQEHTSAGDVFALAGVLTYAATGHGPFGTGQHADLVYRVRYAEPDLTGV
                     PAALVPVLTRCFAKDPADRPTTTDLAAQLAGIPGDFASLLPSALLLEIARRAGGVWSAR
                     PQRLPVPAEHALATTVPGDGPSAPSTPSRRSLLTLGGFTLGAAAAVGGGAWAWLGRGQD
                     TRRNGPGTASPAASPGTPAWDLLWQARTSYADPLLPPAPLLLDGLIVVGEYEVQGLNPV
                     TGEATWPDPDIWFMRRTTTDGERLYAIDDPLGETAPLTITTVDPATGQLGKPFTRLEDL
                     RAGLYGTQLLCATDRAVFVAAGRGPDTDDGFHRDQTWFLLAVDTRTGQRLWESPLPARP
                     HASERLHVLSARAVGEYLVLVQQSADGAPRLAVHDARTGEALWNRPLDGELPVFSRAHL
                     AVDGRHVYPSTGELVALRLADGREAWRFEGRTPGARFGPPTVSDSVVYAMEEGQGMVAL
                     DSANGARRWAQTGQAVTAGDLGTPPVAGIAFVYGKVPSGLMTADLRTGAVSHTVKAAAA
                     RYFAHRSAKRLIAVGDAYTAAYPLA"
ORIGIN
        1 gcccgtcctg ttcggcctga cggtgggcgc gctcaccggc ggcgtggtcg tcggcatccg
       61 tacggcgccc gccctgctgc cgtcgctgtc gcggcggcgc atgctcgccc tcaccctggc
      121 cttcacgggc ctcgcgctgc tcgccgccgg gctcgtcccg gacgtcacca gcgtgctgct
      181 gatcctggcg ctcgccggcg tcggtgcggg catggccgcg aacatcgcgc acaccctgct
      241 cgaccaggag accgaggagc agcgccggcc tcgggtcacc gaacacctgc acgcggtcgt
      301 ccgcgtgtac gtcgggctcg gcgcggtgat cgcccccgtc gtggcggcgg ccatcggccc
      361 gcaccgcctg gagaacggca agttcgtctt cgcccacggc ggcgcagcct tcacgctcat
      421 gctcgtcggc gccctgctgc tgccggtcgc cgcgatggtg ctggccaagg tcgacgaccg
      481 gtccgggatc ccgctgcggc aggacctgcg ggacgcgctg ctcggcggcg acgaccccgc
      541 ccccgcctcc gccggaaccg gcttcttcat cgccctggag ggcggcgacg gcgcgggcaa
      601 gtccacccag gccgaggccc tcgccgactg gatccgctcc aagggccacg aggtcgtcct
      661 cacccgcgag cccggggcga cccccgtcgg caagcggctg cgctcgatcc tgctggacgt
      721 ctccagcgcc ggcctctcgc accgcgccga ggccctgctc tacgcggcgg accgcgcgga
      781 gcacgtggac accgtcgtgc gcccggcgct ggagcgcggc gcggtcgtca tcagcgaccg
      841 gtacatcgac tcctccgtcg cctaccaggg cgccggacgc gacctctcgc ccaccgagat
      901 cgcccgcatc aaccgctggg ccaccgccgg actcgtgccg cacctgacgg tgctgctcga
      961 cgtgtcgccg gagaccgccc gggagcggtt caccgaggcg ccggaccggc tggagtccga
     1021 gcccgcggag ttccacgcgc gcgtgcgctc cggcttcctg accctggcgg ccgccgaccc
     1081 cggccgctac ctggtggtcg acgcgggcca ggagccggag gccgtcacca cggtgatccg
     1141 gcaccggctc gaccgcgtcc tgccgctgtc cgaggccgag atcgccgccc gcgaggaggc
     1201 gcgccgcaag gccgaggaag aggcccgtcg caaggcggag gaggaggcgg ctcgcaaggc
     1261 cgaggaggag cgcctggagc gggagcgcca ggagcagctc gccaagctgc gcgccgagga
     1321 ggaggagcgc aagcggcgcg agctggagga ggcgcagcgg cgcgaggccg agcgccaggc
     1381 ggaggaggcc cggcagcgtg ccgaggaggc ccgccgccgc gcggaggagg agcgtcagcg
     1441 gctgctcgcc gaggagaagg cccgcgccga ggaggaggcg cgccgcaagg ccgaggagga
     1501 gcgccgccgc aagcaggcgg aggaagaggc gcggctgcgc gccgaggccg aggcgcagcg
     1561 cctggagaag cagcgcaagg ccgaggaggc cctgctgcgc gccgagcagg cccggcagct
     1621 cgccgagcgc gcggccgccg cggcggaggc gggcccgcgc acnnnnnnnn nnnnnnnnnn
     1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1741 nnnnnnnnnn nnnnnnnnnn nngcgcaccg cggcgacccc ctccgaggcc ccggcccggc
     1801 ccgcctcggg ccaggacgcc gacgaggcgc tgaccgtgcc gacgccggtg gtcacgccga
     1861 ccaacgcgac cggcggcccc gtggacgaga cggccgttct gccgcgcgtc cgggacgagg
     1921 aggccgcgcg ggacgcggac cgtccggcgc ctgccgacgc cgaggtgacg accgagctgc
     1981 cccggccgca ggtgccgggc gcggccgacg agacggcggt gctgcctccc gtcccgccgg
     2041 gcgcggccga cgagacggcg gtgctgcccc cggtgcgcga ggacgggccc ggtcccgcgg
     2101 gcggcgccga ggaacccgag gaccgtacgc gtgagctgcc gcaggtcgac gccgggaacg
     2161 ccccgcgccg ccgggagcgt cccgactggg cggaggagac cccgctggac gacctgccgt
     2221 cgctggccga cgaactgctc ggcccgcacg aggacgacca cggcgacgac gacggccgtg
     2281 gcggcggacg gtggcgccgg cgctgaatcg catgttgtgc cgtgccgggc gtgccttcgg
     2341 gcgcgcccgg cacggctgtg tccggggatc gtggctcagg gatgtcggtc cggacccgca
     2401 caatggatcc ggcacagtac gaacgcgaac gcgacggaag ggcgggctga cccatgaccg
     2461 tgtgggacga cctggtcggg caggagcggg tgagcgagca gctcgcggcc gccgcccggg
     2521 acgccgacgc gttcgtcacg gccgcggcga gcgacgcgcc cccgcccgag gcgtcccgca
     2581 tgacgcacgc gtggctgttc accggcccgc ccggcgcggg ccgcaaccag gcggcgcgcg
     2641 ccttcgccgc cgccctccag tgcgtcagcc ccgaccgcgc cctcggcggc gcccccggct
     2701 gcggcttctg cgacggctgc cacaccgcgc tcgtcggcac ccacgccgac gtctccacgg
     2761 tggccgccgt cggcgcggag atcctggtca aggacatgcg cgacacggtc cgcaagtcgt
     2821 tcaccgcccc ggcgaacggc cgctggcagg tgatcctcgt cgaggacgcc gagcggctca
     2881 acgagaagtc cgccaacgcc gtcctcaagg ccgtcgagga acccgccccg cgcacggtgt
     2941 ggctgctgtg cgccccgtcc gtcgaggacg tcctgccgac gatccgctcc cgctgccgcc
     3001 acctcgtcct gagcacgccg tcggtggagg ccgtcgccga catgctcgtc cgccgcgagg
     3061 gcatcgagcc ggacgtcgcc gcctccgtcg cccgcgccac ccagggccac gtcgaccggg
     3121 cgcgccgcct ggccaccgat ccggccgcgc gcgcccgccg tgccaccgtg ctgaaactgc
     3181 cgcagcgggt cgaggacgtc ggcggcgcgc tgagggccgc ccaggagctg gtcgacgcgg
     3241 ccgccgagga cgccaagcag ctcgccgagg agatggacgg caaggagacc gaggacctga
     3301 aggcggcgct cggggcggcc cagggcggcc ggctcccgcg gggcacggcg ggcgtggtca
     3361 aggatctgga ggacatgcag aagcggcgca ggacgcgcac ccagcgcgac agcctcgacg
     3421 tcgccctcgc cgacctcacc agcttctacc gcgacgtcct cgcgctgcag ctcggctcgc
     3481 gcatcgccct cgccaacacc gacgccgagg acgcgctgga gcgtctggcc cgcagcagca
     3541 cgcccgagtc cacgctgcgc cgtatcgagg cgatcgcggc ctgcggcgag gcgctggacc
     3601 ggaacgtggc gccgctgctg gcggtggagg cgatgacgat ggcgctcagg gcgggatgac
     3661 gctcagggcg ggctgagcgg ggcgtcgtcg cgcggtggcg taactcgtcc ggggcacggc
     3721 gtgtacgcag agcttccgtg ctgtcgctca ccgttacgct cccggtatgc acacacggcg
     3781 caccccccgc aggacccgta ccgcagcagc cctgttcacc gcagccgcgc tgttgtcggc
     3841 gggctgctcc tccggcacct cgacgaacac gacggccagt tcaccggtgg cgggagcggc
     3901 cgccgccctc gccccactgc ccggctcgac ccccgcggcc ctcgccgagt actacgcaca
     3961 ggaaccggcg tggcgcgact gcggcgtccc cgggttccag tgcgccacgg tcaaggcgcc
     4021 gctcgactac gccgaaccgt ccgcagggga cgtccgcctc gccgtcgccc gcaagaaggc
     4081 caccggcccc ggcaagcggc tgggctccct gctggtcaac ccgggcggac ccggcggctc
     4141 ggcggtcgac tacctccaga tgtacgcggg catcggctac cccgaggagg tgcgcgcccg
     4201 ctacgacatg gtggccgtcg acccgcgcgg cgtcgcccgc agcgaacccg tcgagtgcct
     4261 ggacggacgc gcgatggacg cgtacacccg cacggacacc acgcccgacg acgagaagga
     4321 gaccgagacc ctcgtctcgg cgtaccggac gttcgccgag gggtgcgggg cgaaggcgcc
     4381 gaagctgctg cgccatgtgt cgaccgtcga ggcggcccgg gacatggacg tcgtgcgggc
     4441 ggtgctgggc gacgagaagc tgagttacgt cggcgcgtcg tacggcacgc tgctgggcgc
     4501 gacgtacgcg gggctgttcc cggagcggac ggggcggctg gtgctggacg gcgcgatgga
     4561 cccgtcgctg agcgcgcgcc gcctcaacct ggagcagacg gagggcttcg ccaccgcgtt
     4621 cacggcgttc gcgaaggact gcgtgcggcg cagtgactgc ccgctgggcg gcaagggcac
     4681 gagcccggag aaggtcggcg agaacctgaa ggcgttcttc gagaagctcg acgcccgccc
     4741 gctgccggcc ggggacgccg acggccgcga gctgaccgag tcgctggcga cgatgggcgt
     4801 gatcgccgcg atgtacgacg aggcggcctg gcagcggctg cgcgaggcgc tgacgtcggc
     4861 gatgaaggag aacgacggcg ccgggctgct ggtcctctcc gacagctact acgagcggga
     4921 cgcgggcggg gcgtactcca acctgatgtc cgccaacgcc gccgtcaact gcctcgacct
     4981 gccgcccgcc ttcgagaccc cggagcaggt gcgggaggcg ctccccgact tcgagaaggc
     5041 gtccccggtg ttcggcgagg gcctcgcctg ggccgcgctg aactgcgcgt actggccggt
     5101 gcgggccacg ggcgaggcgc agcgcatcga ggcgaagggc gcggcgccga tcgtggtcgt
     5161 cggcaccacc cgggacccgg cgaccccgta ccgctgggcg gagggcctgg ccggccagct
     5221 ctcctcggcc cgcctcctca cctacgacgg cgacggccac accgcgtacg gccgcggcag
     5281 ctcctgcgtc gactccgcga tcaacacgta cctgatcgag ggcacccctc cggcggacgg
     5341 aaagcgctgc tcgtaaccgg tacggccacc cccggaggcg acggccccgc cccgcctccg
     5401 ggggcggtac gaagcacccc cggaaactgt gtagacttac cgacgtcgct gatcgcacca
     5461 tggtgcacac ggcgtgccgc cttagctcag atggccagag caacgcactc gtaatgcgta
     5521 ggtctcgggt tcgaatcccg aaggcggctc ttcttcaagc cccgcgcaga cagtgtctga
     5581 gcggggcttc ttcgttccgg tgcgttcacg cgctgttccg gaccagttcc ccggcgggct
     5641 cgccgaagcc cgcgtcccgg gccatcacca ccgccgtcgc ccggtcgtgc acctcgagct
     5701 tggtgaagat gcgcgagacg tagttgcgca cggtcttctc ggccaggaag agccggcggg
     5761 cgatctgccg gttccccatg ccgccggcca ggagctccag tatctccagc tcgcggctgg
     5821 tcagccccgg gaacccgacg ctgtcgttca ggccctgcat cgcggagaag tagcggctca
     5881 tgcgggccgc gacgctgggg cagaaggcgg cgccgccccg ggcgacgacc ttcagggagc
     5941 ggagcagttc gtcggccgaa ccgaggcgcg agaggtagcc gttgacgccc gcccggaggg
     6001 ccgagacgat catctggtcg tcgtcgttct gcgccaccac gatcgtgtgc ggccgggacg
     6061 cctcgtcggg gaaggcggag gcgatgtgcc ggacgtgtgc ggagacggtt ctgctggagc
     6121 acggttcgct gaggacgacc acgtcggggt ggagggcggt gccggccagg tccgacagac
     6181 atcggaggtc gtccgagtcg tccgtggcac ggccgacgag agcgcactcc ttatcctgat
     6241 cgacaatcgc ttccagcccg gcgagggaca ccgggttgtc gctgaccacg aacaggttga
     6301 cggtcatctc gtacatcccc cagaaatgcg tcggcgtggt gcggacggcg ccggacggtc
     6361 ccccgggggc acacgcgacg aagggccggt ccgtgtgcga ccgactccgg gcgtgatgca
     6421 gtcagttgtg gcgtgcggtg gcccccgtgg ccatgacctg tcggcgcagg catggtgtgc
     6481 gtcggagcgc gcagggcgct cgtgatgctg agtatgtgga cgcgtgcgga gagaacgcaa
     6541 ggtcccccat gcccccgcac cgtccgaggg gtgagtatcg gccggacccc gccgaaccac
     6601 cgcgttcccg gcgtcggcgg tggtgggggc ggctccgggc gcgcgccccg caggaccgca
     6661 cgcccgggtg ggccgcggtg cggggcggac gacactggcc gaaacggtca ccgcgcggcg
     6721 cgacacgcgg acgcccggcc ctgcgcccgt tggacgggcc gtggagcgag cgcctacgtt
     6781 cgacggcatg ggtgaggggt cccggaggcg tgcgatcgtg ctggacgggg ctgcggcctg
     6841 cgtgttcacg ctcctgccgc aggtgtcgct gctgcggccg gccgtcgacg gcgggacggg
     6901 cggcggcgtc ctgtggctgc tgtccctggg cgccggactc ccgctcgtcg tacggcggtt
     6961 gtggcccgtc ccggtcttcg tcctcgtcct ggccgccgcc tgcggggcgc tggccgcggg
     7021 cctcggaccg gccgcgttcc tggccgccgc ctacgccgtc tacacggtgg ccaccacccg
     7081 gcggcgcgac cccggggtgt cggccgtcgc cgtcgccggg ctgtgcgcgg cggtcgcggc
     7141 cctgctcacg ctgtcgggcg ggcagtccta ccagggcggc agcaccgccg tgcaggccgt
     7201 gttcggcctc ctcgtgctcg gcgcgacctg ggcggccggc tcggcggtca gggagcgcag
     7261 acgcagtacc cgacgtgcca tcgagcacgc cgccgagcag gcgaagaccg aggagcgcct
     7321 gcgtatcgcc cgcgacctgc acgacgtcgt cacccacagc gtgggactca tcgccgtcaa
     7381 ggccggcatc gccaaccacg tcgtggccac ccgtcccgaa gaggcgaagg aggctctggc
     7441 ggtcatcgag gacgtcagcc gccgggcgct gcgcgacatg cgcgccaccc tgaccgtgct
     7501 gcgcggtgag gaccggagcg acgccgggga cctgcggccc gcccgcggcc tggcggacct
     7561 gcccgcgctg ctcgggaccg ccgaggcggc gggcgtccgt gtcgaactgc gcacccgcta
     7621 cgaccaggag ccgcccgagg gtgtcgcgct ggcggcgttc cgcatcgtcc aggaggccct
     7681 caccaacgtg gtcaagcacg ccgcgccgac cggctgccgg gtggacgtca cggcgcggga
     7741 gggcgtgctg acggtggagg tgaccgacga cggccccgcc cccggacgcc ggaccacggt
     7801 gcccggcggc ggcatggggc tggtcggcat gaaggagcgg accgccgcgc acggcggcac
     7861 cctcagggcc ggcccccggc ccggcggcgg cttccgggtg acggccaccc tgccgttcca
     7921 ggtctgacag cccgacggcc accgactcat cctcgggtat gaggagcgcc cgcgcggcac
     7981 cgcgccgggt tcccgaccgc ggaccgatgc ggtcgcgggg tgcccgccgc gagactcgac
     8041 gtgtgatgct tgccgagaga ctgaccaagc ggtacgggcc cgccaccgtc gtcgacgacc
     8101 tgtccttcac ggtgcgacca ggggtcgtca ccggcttcct cgggcccaac ggcgccggga
     8161 agtccacgac gatgcggatg atgctcggcc tgacccgccc cgacagcggc acggccaccg
     8221 tcggtgtacg cccctaccgc gacctgacct acccgctccg gcacgtcggc gcgctcctgg
     8281 agacgtcggc cccgcaccgt ggcatgaccg ccgtcggcca tctgtcgtgg ctggcgcgca
     8341 gcaaccgcat cccccgccgg cgggtggacg agatgctcga cgcggtcggt ctgacgggag
     8401 ccgcccgtca gcgggtcggc accttctccc tgggcatggg acagcgtctc ggcctggcgg
     8461 cggccctcct cggcgacccc ccggtcctgg tgctcgacga gccggtcaac gggctcgacg
     8521 ccgagggcat ccggtggctg cgcgaactgc tgcgtgccaa ggccgccgag ggccgcaccg
     8581 tcctcgtctc cagccatctg atggcggaga tggcgcaggt cgccgacgag ctgatcgtga
     8641 tcagccgggg ccgcctcctc gccgagacca gtgtgtcgga gttcatcgga cgccatggcc
     8701 ggacgttcgt acgggtccgg acccccgaac cgctgcgggc cgcgcaggag ttccaggcac
     8761 agggcgccgc ctcggtgcgg cgggccgcgg acggcggcct ggaggtggac ggcctgccgg
     8821 cgggcgaggt gaaccgcatc gccgcggcgg ccggcgtccc ggtcgaggaa ctgagcaccc
     8881 acaccggctc gctggaggag accttcctca agctcgtcga cgacggagga gatcccacgc
     8941 atgtctgaga cgctcgcggc cgctcgggcg gagttcacca agatgcgggc ggtgcgcgcc
     9001 acgtccgtcg cgctgctgct gttcgtcgcc gtcagcgtgt tcatcgccgc gctgggcggc
     9061 tggtccgcca agggcgcgat cgagtccgac aaccccgggc tgcgctccga cttcacgccc
     9121 gagcaggccg gcctggacgg catcctctac ggccagctcg ccctgatcgt gttcggggtg
     9181 ctgatgatgt ccggcgagta cacgtcgggc acgatgcggg tctcgctgct cgcggtgccc
     9241 cggcgcggcc ggctctacct ggccaagacg gccgtcaccg ccgccgcggc cctggccgtc
     9301 gccctcccgg tcacggtcgt gtcgtacctg gtcacccaac tcgccctggg ccctcacggg
     9361 tccacgctcg acgcggacgg cgtcccgcgt gccctggccg gcggggtcgt ctacctcacc
     9421 ctcatgagcc tgctcgccgt aggggtggcg gccgccgccc gcagtgccgt cctcccgctg
     9481 gccgtgctgc tgcctctggt gctggtcggc tcgcagatcc tgtccgtcat cggggcgacc
     9541 aaggaggtgg cccgctggtt ccccgaccgg gccggcgccc agatgctcac cgtcgactcc
     9601 ggtgacgccc tcaccggcct cgtcgtgctg ctcgcgtgga ccgcggccgc gctgacggcc
     9661 ggctgggtgc ggcatcgctc gtgggacggg tgacgggacg ggcctgagtc atgtgcccca
     9721 tgcacgtggg acatggtccc tcgtaggttc ccggacaggt cacggagccg aaaaggtcgg
     9781 cccgggccgt tcgacccacg ggaggaacca tgaccgcgat ctacgagccg cccgccctgc
     9841 aggagatcgg cgacttcgac gagctcacca agtgcctcgg catcgggagc tgcaacgact
     9901 tcgccggctg cggttacgcc gtcgtctgct tctggtgatc gcaccggtgc cggtgtgccc
     9961 ctcgcggcac accggcaccg cccgggggga gtgaggcgac atggaattca cagtgcttcc
    10021 ggactgtccc gccggcgccg cgctggcgga ccgggtggcg gcaccgaagc ggatcgacca
    10081 cgcgtcggga cggccctgga tcgtggggga ctgggccgtg ggcgaggcga cggtgaccga
    10141 ggccggcatc cgccgcctgg cggtgttcgg acacacccgg cccgacgacg cgggaacggt
    10201 ctccgcgctc ggccggatgc gctcgctgca cgacgtcgac cgggtcgcgt cccggctgcc
    10261 cggggtcttc cacctcgtgg cctccctgga cggcgcggtc cgcctccagg gctccgtggc
    10321 aggcgtacgg caggtcttca ccacccgggt cgacggggtg acggtcgccg cgagcgccgt
    10381 ggacccgctg ctgcgcctca ccggcgcggg actcgacgag accctgctgg ccgcccggct
    10441 gctggccccc ggcggggcgc cctggccgct ctcgctgcgc ccggtccgcc gcggcgtgga
    10501 cgcgctgccc accggccact ggctggagct cggcgccgac ggacgggccc gcagcgtgcg
    10561 gtggtgggaa ctgcccgagg cgaccctctc gctggaggag ggcgccgggg ccgtccgctc
    10621 cgcgctcacc gacgcgctcg cgacccgcgt cgccccggac cgcacgatca gcgcggacct
    10681 ctccggcgga ctcgactcga ccaccctgtg cttcctcgcc gacgcggccg gcgccgacct
    10741 ggtcacctac cacgtcatgc cgctcgacga ggccaacgag gacaccgcat gggcccgcaa
    10801 ggccgccgcg catctgccgc acgcccgcca ccacatgctc gccgcggacc gcgccgccaa
    10861 cctgttcgac gtcggctaca ccgccgacac cgccgacgcg gcgcccgagg gtccctcgac
    10921 gtgggcctcg ggcctcgcgc acatccggga cctcgccggg cgggccaccg ccgagggcgc
    10981 ggccctgcac ctgtccgggt tcggcgggga cgaactcttc gggcggatgc ccgcctgcgc
    11041 ctggtccctc gcccgcatcc gtccggccga cggcctgcgg ctggtgaacc gctaccggct
    11101 ggccaaccgc tggccgtggc gcagcaccct gcggcagctc gcggaccgtt cgacgttcgc
    11161 gcagaacctg attgaggtcg ccgggcggat caccgccccg cccccgccgg tcaacgagcc
    11221 tgacttcggc tgggtgttcg cgccgcgcat gcccgcctgg gccaccccgg acgcggtggc
    11281 caccgtgcgg gacctgctga ccacggcagc cgaacggacc ccggaaccgc tggacgccga
    11341 ccgggcccgg caccaggctc tgtcctccgt cgtgttcgag gggaacaccg tccggcaggt
    11401 caacaccgcc gtcgccggca ccgggctggt ctgggaggcg ccgttcctcg acgaccgggt
    11461 tctcgaggcg gccttcgcca cccggatcga cgagcggctg gccgccggac ggttcaagcc
    11521 gctgctgacc accgccgtgc ggggtctcgt gcccgacgac ttcctcgccc gccgcgacaa
    11581 gggcgagttc agcgccgaga cgttccgggg catcgaacgc aaccgggacc ggatcctgga
    11641 tctctgcgag gactcgctcc tggcccggct cggcctcgtc gacccggtcg ccttccggtc
    11701 cgcggtgctc aaccccgggc cgatgtccca tcacctccag ccgatccaga ccacggtggc
    11761 gtgcgagagc tggctgcggg cgcaccccca ggactccgga gagaaccgat gaaactgagc
    11821 cttgcccgcg acgtcaccct cacgcccgtc gattccgggg cggtcctgct cgacggccgc
    11881 cgcggccgct actaccagct gaacgcctcc ggctccgcga tcctgcacaa gttgctcgac
    11941 ggcgacacgc ccgccgcggc cgccgcgagc ctgtcggagt ccgcccccgt cagcgaggag
    12001 cgggtgcacc aggacgtgct ggccctggtc cgctcgctga gcgaggccga cctcgtggag
    12061 gtgacgcagt gaccacgccc gccgtcgccg aacaggccac gcgcctcccg ctgcaccggc
    12121 agatcgcccc gagatgcgcg gccggcgccg cccgcctgct ggtcggactg cccccggccc
    12181 ggctgcaccg ggtgctgcgc gtgctgagca agggctcccg gcccgccggg tacgcccagg
    12241 tggcacgggc ccggcggtcc gtcgtctcgg tcagcacccg ttgcgcgggc ctcggctgcc
    12301 ttcagcggtc cgtcgccacc gtgctgctgc tccgtgtccg gggcaggtgg gccgactggt
    12361 gcaccggctt ccgggtgcag cccttcgccg cgcatgcctg ggtcgaggcc gacggccgcc
    12421 cggtcgacga gcccggagag gtcggcgtgt tccgcaccgt gctggccgtg cgccgcaccg
    12481 gaggcggctc atgacggcga tccgggccga gggcctctac gcgtactacg gcaccacacc
    12541 ggccgtgaac ggcctcgacc tgaccgtccc cgagggggcc accttcgggt tcctggggcc
    12601 gaacggcgcc ggcaagacca ccaccatcag catgctgacc acgctgctca ggcccacggc
    12661 gggccgcgcg gaggtggccg ggttcgacgt caccacgcac gccgccgagg tgcggcggag
    12721 gatcggcatc gtcttccagg aatcgacgct cgacctggag ctcacggcca ccgagaatct
    12781 gcgcttccag gccgacctgt gcggtctggg ccgggccgag gcacgcgccg cggtggccgc
    12841 gatgctcgac atgatggagc tcacgggacg cgacaggacc cccgtacggc acttctccac
    12901 cggtcttcgc cggcgcctgg agatcgcccg cggcctgctc ggctccccgc gcgtgctctt
    12961 cctcgacgag ccgaccaccg gcctcgacac gcagacccgc gcggccgtct ggcaccacct
    13021 ggaccggctc cgcgaggagc agggcatcac ggtcttcttc accacgcacc agctggagga
    13081 ggccgagcac tgcgaccgca tcgcgatctt cgacagcggc aagctggtca cggagggctc
    13141 accggcggag ctgaagtccg tcatcggggc cgacgtcgtc gacctgcgca ccgaggacga
    13201 ccggctggcc gtggacctgc tgtccgaccg cttcggactg acggccgaga gcgtccccgg
    13261 cgggctgcgg ctgagagtgc aggacggtgc ctccacggtg ccccggctgt gcaccggact
    13321 gggcctgacc gtgcggtcgg tgaccgtcac cccgccctcg ctcgacgacg tctacctgca
    13381 ccacaccggg accgcgatca gggacagcgg gtccgacgcc cgctcgctcg acagcctcgg
    13441 ggagggactg cgatgacccg gaccgacatc ccgccgagtg tcaccctgac gaaaccggcc
    13501 ccgtcctcgt ccgaggcgcg tacctggcac accgtacggc cctacgcgct gctgtggcgg
    13561 cgggagatga cccggctgcg gcacaatccg ctgcgcctcg tcatgggcct ggtcaccccg
    13621 ctgctgttcc tggtcgtgct gggcacgggg ctggaagcgg cgtcgtccac gctcggcaag
    13681 gcccagctga acgactaccg ggcctacctg ttcccgggcg cgctcgtgat gtccgtgcag
    13741 gccccggcca tcgccgtggg catctccctc gtctgggacc gccggctcgg catgctgcgc
    13801 cagatgctcg tctccccgtt cccacggtcg agcatcgtcc tcggcctcgc gctcggcgga
    13861 gccaccacgg gtgccgtcta cggcctcgcc ctgctcgccg tcggaggcat cgcgggcgtc
    13921 cggtacacgc cgatgctgct ggtcgtcctc gtcgaactgc tgctggtctc gctgctcttc
    13981 acctcgttcg gccttctcgc cgcggtcacc atccggcagg tcgacacctt ccagatcgtg
    14041 gtgaacctca gcctcatgcc gctgatgttc ttctccggcg cgatgttccc gcccaacggg
    14101 ctgccgggct ggctcgacac cgtcgtcaag ctgaacccgc tgacctacgg cgtcgacgcc
    14161 gtgcgccgga ccctgcccgg ccccgacgtc ctcacctcgg agcagacccg gctgatgctc
    14221 ggcgactgga acccgcccgt gtacgcggaa ctcggtgtgc tggccgccct caccgccgcc
    14281 gtactgagcc ttgccaccta ccggttctcc cggacgcagt gaaagggggc cggccgtgac
    14341 gttcgtgcgg acatgggcgg gcaccgcggc ccggatcgtc ctcgcggcgg tcctgggcta
    14401 cgcgggctgg gtgaaggtcc aggacctcac ggaggccggc cgtaccgtcg ccctctacca
    14461 gttcgtcccc gaggagagcg cgcaactcgt cggcgcagcg gtggcgttcg tcgagctggc
    14521 gctggccctg ctgcttctcg ccgggctcgc cacccgcgcc gtggcggccg tcaccgccct
    14581 gctgatggtc acgtacatcg cggccatcgc ctcggtgtgg gcgcgcggga tgtccatcga
    14641 ctgcggctgc ttcagcagcg gcggcaccct caccggcggt gcggaacggg gctacgtcgt
    14701 cgacatcgcg cgcgacctcg ccttcctcgg cgccgccgcc ttcctgatca cccgcccgcg
    14761 aacccgttac gccctggacc gctgggtcct ggagacgaag gagcgttaga catgcagccg
    14821 tcgacggacg cccaggtccg ggaaatggtg caccggcgcc ggcggcgccg ccgcaccgtg
    14881 ctggtgtcgc tcgcggcggt ggtcacggtg ctcggcgccg cgctcgtcgg cgccgggctc
    14941 gtccgggcca ccaacaccga gcccggcgag gcccccgagg aggtccccgc cggcgtggcc
    15001 gccgaccggg ccggcctggt cacgtccgag ggcccggtcc gggtcgacct ctacctcgac
    15061 tacctctgcc cggagtgccg catcaccgag aaggccctcg agcccaaact gaggaagatg
    15121 caggaacgcg gagaggtgcg cgtcgtccac cacccggtcg ccttcctcga cgaccgcagc
    15181 gcacccgccg gctactccac ccgggccgcg tccgccgccg cctgcgccgc ggaccagaac
    15241 aagttccagc cctacacggc ggcgctcttc gacgagcagc cgccggagca gggccccggc
    15301 ctcgacaccg accgcctggt cgccctcggc cgggacgtcg gcatcacggg cgcgtccttc
    15361 gagcggtgcg tccgcgacgg cacgtaccgg ccctgggtga cgtacgtgtc cgacgtcgcc
    15421 gcctcccgcg gggtggccct caccccgacc gtgaaggtgg ccggcaagcg cgtggagctc
    15481 tccggacccg accgggcgaa ggcgttcgtg cgggcggtgg aggaaagccg ttcatgagcc
    15541 gcctgaccgt ggccctgacc ggggactgca tgacgacgcg gggcgcgccg ctcacctccg
    15601 accccgccgc cggccggctg ggcgaggtgc tgcacacggc cgacttcgcc ttcaccaacc
    15661 tggaggtcgc gcccgccacc ggacgcggcc acccggtgcc cgacgcggcg agcggaggcg
    15721 gcctgatcgc ggaccccgcc gtcctcgacg acgtgaccgc gatgggtttc tcggccctga
    15781 gctgcgccaa caaccatgcc ctcgacctcg gtacggaggg cgtcctcggc acggcggacc
    15841 tgctgcgggc caagggggtg ccgttcgcgg ggatcggcgc cgacctcacc gctgcccggc
    15901 gcccggtgta cgtggaccgg ccggccggca gtctggcgct gatcgcgtgc accgccacct
    15961 tccgggacgg gcaggaggcc gccgttccgt cccccgacct gccgggccgg ccgggggtca
    16021 acccgctgcg gcacggcgtg acgctccggg tcacggccgc gcagctggag gcgttgcggg
    16081 agatcgacgg cgtcacagga ctgcggtcgc ggcgggccga ggcgcgcacc ctgctcgggt
    16141 tcgaccccgc catgcccgga ccgggccggc tcgcgctgtt cggcacccgc ttcgagaccg
    16201 cggacacgcc gggcctgacc accgcctgcg accctcggga cgtccacgac atcacccgct
    16261 gggtggccga ggcgcgccgc cgcgcggacc tggtcctggt cagcgtccac tcccacgaac
    16321 ccggcccgac acccgagacg cccgccgagt tcctgcggga cttcgcccgc gcggtgatcg
    16381 acgccggcgc cgacgccgtg gtcgggcacg gcccgcacat gctgcgcggt gcggaactgc
    16441 accggggccg gcccgtcttc cacagcctgg gcaacatcgt cagccagata gaactggccg
    16501 accgcgtccc ggccgaggac tacgcgcggg ccggtacgga cgaggccctc acccccggcg
    16561 cctacttcga gcgcatcacc gcccacggcc ggcgcatgtt cgccccgcac cgccggtact
    16621 ggcagtcgct cgtgccggtg ctcaccttcg acgacggcgt cttcaccggc gcccggctgc
    16681 acccggtcga cctgggcttc gggcagcccg tgcaccggcg aggacggccc cggctggccg
    16741 gtccggtcga cgccaaggag atcctcaccg acttcgcgcg gctcgcggag ccctacggcg
    16801 tcaccgtcac cgtcggggac gacgggacgg gggaactggt ggcggcggaa acctgacggc
    16861 ggccgccggc ccggccgata gagtgccgga gagacaggct gacgaggcgt cgcaccgccg
    16921 gccacggcgg cgacccgagg tacgagggat gcggaatggc cgaggcggtc cgggtcctga
    16981 tcgcggacga ccaggcgctg ctacgcggga gcttccgggt cctcgtcgac tcgactcccg
    17041 gcatggagac ggtgggggag gcgggggacg gcgccgaggc cgtcgcgctc gcccgtgaac
    17101 tgaccccgga cgtcgtcctg atggacctgc ggatgcccgt catggacggg atcgccgcca
    17161 ctcgcgagat ctgctccgac gcggccctgg cgggcgtgcg ggtgctggcc ctcacgatgt
    17221 tcgacatgga cgagtacgtc tacccggccc tccaggcggg tgcgagcggc ttcatgctga
    17281 aggacgcctc gccggacgac ctggtcacgg gcatccgcgt catcgccacc ggcgagggcg
    17341 tgctggcccc ctcggtcacg cgccgcgtca tcgcgaactt ctcccaccag gacacggccg
    17401 cccggccggc cccccggctg gtcggcctca cccggcgcga acaggaagtg ctcgtgctga
    17461 tcgccaaggg cctgtcgaac gcggagatcg cggaccacct ggtgatcagc ctgcccacgg
    17521 tgaagaccca cgtgagcagc ctgctctcca agctcaacgc ccgcgaccgc gcccagctgg
    17581 tcatcgtcgc ctacgagagc ggcatcgcgg agcgggggat gccgccggcc tgagcgggtc
    17641 gcgccccgca ggcggtcgct ttgaccgctc cgtcccgcgt ggcagggggt gcggggcacc
    17701 gctgagttct cgccgcctcg tcggtcgcgc gcacgacggc ttcacgaccc aggtgcaggg
    17761 catgcccgcg gccgccgtgc ccttcacgaa gggctggcga cggagcgggt gccgttcccg
    17821 gtcggctccg gtcctcagaa caccggcaag gcactgagcg acgtgccgtc cacgaggaag
    17881 acgcggttgg cgtctcccgt gatccagtag cggtcgcggt tccggagcac gggaaacgtc
    17941 cacgtcgggc gctgttcctg ggagaggtcc agggcctgga ccgctgcctg ttcgccgtcg
    18001 gtggccaccg accacagtcc gctgccctgc agcacgagcg ggctgcccgc gtcgcactgg
    18061 aggagaccgg tgtggatcca gtcggtgggc cggcccgtgc ggaggtcgag ccgcaccggg
    18121 aagacgacct cggtcgcgta cacggtccgg ccgtcgacgg tcggagagct ccagaaggcg
    18181 gggtcgccgc tgggctggtc cggggtctcg gtcgaccaga gttccttgcc gtcggcgagg
    18241 tcgtaggcgg ccagctgcct gccggccacg cacagagtgc cgcccgaccg gtcggcgtcg
    18301 gcccggcccg agtcggtcag cgaccggtgc tgccacacct gccggccgtc ggcggtgtcg
    18361 agggccgcca cggagccgtc cgcggccgtg acgaccagcc tgcgccgcgc ggcgaggccg
    18421 cgtgacgcgg ccttctcacc gaggtccgcg tcgatcggca cggtccagcg gaccgtggcg
    18481 tcggaccggt tcacggcgcg gatccggccg tcctcggtga tcagatacac cgcctcggcg
    18541 tccgcgtcga gcagtgaggc ggcccgcgcg ggcgccgtcc atttgggctc gccggtggag
    18601 gcgacgaagg tgacgagcgt gccttcacgg tccacggccg ccaccagccg gtcggacagg
    18661 gacaggtagc ggcccgtggc ttccacgtcc ggcgccgacc agcggaccga gccgtcgacg
    18721 acgctgtgcg cagcgatgcc gcccttcgcc gccgcgacga cgaggacgtc gcggacggga
    18781 aggggcgccg cggggcggtc ggagagcgcc gacggcgcct gccagagcgg ttcgggagcc
    18841 tcaccgagga cgtagtcgcc cttcgccgcg tccagagcac gggccttcgg ggccgcgacg
    18901 gccggaggga tgtcgaaggg gtcgtcgccg tccgtcctcc agttccacca tgccgcagta
    18961 ccgccgacgg cgagcacgga ggcgccggcg gcgagccccg tcagcagacg gcgtcgggat
    19021 acgggacgcg gtgcgccctc gtccggtacg gccgtcagct cacggacgcg ctgctcccgg
    19081 agtgtgatgt cctgcgcgat cggcccgccg cgccacgcgc ggtccgcgcc cgcgggcgga
    19141 gccgagtact ggacgatctg gtccgggagg ggccgggccg ccgggtcctg ggcgagacac
    19201 ggtccgatca gcggccggag agaggggggt acccggtcca ggcgggcgct ccgtggacga
    19261 cctcgtactg cacggcggcg acgtgcgccc cctcgtacgc gtgcagaccg ctcgccgcgt
    19321 acacgaggac ggcgcccagg gagaagacgt cggcgggcgg gccgacgcgc cggccgagga
    19381 cctgctcggg ggcgccgtag ccgggggtga ccggggcctg gccggtcgtg gtcagggtga
    19441 ggccgtgttc ggggcgggcg atgccgaagt cgatgacacg ggggcccgtc gaggtgagca
    19501 cgatgttggc gggcttcacg tcgcggtgga cgagccccgc ggagtggatg tccttgagcg
    19561 cgggcgagcc ccgcagccag ggcccggacc gtcggttcgt cgagcggtcc gtgggacccg
    19621 accacgtccg cgagtgtggg gccggccagg aactcggtgg cgatccaggg acggccgtcc
    19681 tccgtccggg cgtccaggac acgggccacc gtcgcggacg tgaccgcccg ggccatctgc
    19741 gcctcgcgga cgaagcggcg ggcaaggccg gcgtcgtggg ccaggtgcgg gtgcagcacc
    19801 ttcacggcgg cgacgcggcc ctcgccgtcc cggccgacgt agaccttgcc catgcctccc
    19861 tcgcccagta cgccgtggac gcggtacgga cccagacgga tcgggtctcc ggattcgagg
    19921 ggcttcatgg tgggtgcggc tttctgtgag ttcaggcgag ggggtacgcg gcggtgtacg
    19981 cgtctccgac ggctatgagc ctcttggcgg accggtgggc gaagtaccgc gccgcggcgg
    20041 ccttgacggt gtgggacacg gcgccggtcc gcaggtccgc cgtcatcagc ccggagggca
    20101 ccttgccgta cacgaacgcg attcccgcga cgggcggtgt gccgaggtcg ccggccgtca
    20161 ccgcctgacc ggtctgcgcc caccgccggg cgccgttcgc gctgtcgagc gcgaccatgc
    20221 cctggccctc ctccatcgcg tacacgacac tgtcgctgac cgtcgggggg ccgaaccgcg
    20281 ctcccggagt ccgcccctcg aagcgccacg cctcacggcc gtcggccagg cggagagcga
    20341 cgagttcgcc cgtcgagggg tacacgtgac gaccgtcgac ggccaggtgg gcacggctga
    20401 acaccggcag ttcgccgtcg agcggacggt tccagagcgc ctcccccgtc cgtgcgtcgt
    20461 gcaccgcgag ccgcggtgcg ccgtccgccg actgctggac gaggaccagg tactcaccca
    20521 cggcgcgggc ggagaggacg tgcagacgct cggaggcgtg gggccgggcg gggagcgggg
    20581 actcccacag ccgttggccc gtccgggtgt cgacggccag caggaaccat gtctgatccc
    20641 ggtggaagcc gtcgtccgtg tccggtcctc gtcccgcggc cacgaagacg gctctgtccg
    20701 tcgcgcagag cagctgggtt ccgtagaggc ccgctcgcag atcctcgagc cgggtgaacg
    20761 gcttgcccaa ctgacccgtg gccggatcga ccgtggtgat ggtgagcgga gcggtctccc
    20821 cgaggggatc gtcaatggcg tagagcctct cgccgtcggt ggtcgtccgg cgcatgaacc
    20881 agatgtcggg atccggccat gtggcctccc ccgtcacggg gttcaggccc tgtacctcgt
    20941 actcgcccac gacgatcagc ccgtcgagga ggagcggggc gggcgggaga agagggtcgg
    21001 catagctggt ccgcgcctgc cagaggaggt cccacgcggg tgttcccggt gacgcggccg
    21061 gggacgccgt gcccgggccg ttccgacggg tgtcttgccc gcggccgagc caggcccatg
    21121 ccccgccgcc gaccgctgcc gccgcgccca gcgtgaaacc tccgagcgtg aggaggctgc
    21181 ggcgggacgg ggtggacggg gcggacgggc cgtcgcccgg aacggtcgtg gcgagagcgt
    21241 gctccgccgg tacgggcagg cgctgcggcc gggcactcca gacaccaccg gcgcggcggg
    21301 cgatctccag gagcagggcc gaagggagga gactggcgaa gtcccccggg atgccggcca
    21361 gctgagcggc gagatcggtg gtggtggggc ggtcggcggg gtccttggcg aaacagcggg
    21421 tcaggaccgg gaccagggcc gcggggaccc cggtgaggtc gggttcggcg tagcggacgc
    21481 ggtagacgag gtcggcgtgc tgtccggtgc cgaagggccc gtgtccggtg gccgcgtacg
    21541 tgaggacccc ggccagtgcg aagacgtcac ccgcggaggt gtgctcctga ccggtggcct
    21601 gttcgggcga catgaaggcg ggcgtgcccg cggccatgcc ggtgcgggtg agccggtcgt
    21661 cgcccagggc gcgggcgatg ccgaagtcga tgaccttggg accgtccgcc gtgatcatga
    21721 tgttggaggg tttgaggtcg cggtggacga cctccgaggc gtgcagctgc cccagcgctg
    21781 cgcacagcag ggcgccgagg cctcgcaccg tcggctcggg gagggggccg gcgagggcga
    21841 cggcgtcgtc gaggggcggt ccgatgacgt actcggtggc cagccacggg gtgtccgcct
    21901 gcgggtcggc gtcgaagacg cgggcgccgt gcacgggtcc gatgacccgg gccgcgtccg
    21961 cctcgagacg gaaacgggtg cggaacgcgg ggtcggtggc gatacgggcg tgccggaagt
    22021 ggaccgccgt gggcgcgcag ggccgcggga agggagacgg ccgggatgta cggcgtcgcg
    22081 caccagggca ggtcctccgt accgccgacc tcctcgaccg gcaggaaccc cggtgtcgcc
    22141 agccgtcgtg cgccctccgc ctcgaccgcc cagcgggccg ggtccgcacc tgggaccggc
    22201 agacggacga ggagcgtgcg gtcaccgtcg gcgctgcgcg cgatgaaacg gcgttcggcg
    22261 acggcgtggt ccggttcccg ctcgagccgg gcgaggatgc ggtgcggccc ggcccaggcc
    22321 gggtcgtcgt gacgcggacg ttccatgcga gctcccccga gtccgtgatg atcgcgaacg
    22381 agcctactca cgcgtccctg agagcccggg gccggtgtcg gccgtcgctg cggccgaaaa
    22441 gaacgaggcc ccggtcgttc acctctggcg accgggtcct cgtgaagcgg atcc
//
