LOCUS       NZ_KL503830            11380 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Streptomyces griseorubens strain JSD-1 scaffold1, whole genome
            shotgun sequence.
ACCESSION   NZ_KL503830
VERSION     NZ_KL503830.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces griseorubens
  ORGANISM  Streptomyces griseorubens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces althioticus group.
REFERENCE   1  (bases 1 to 7563100)
  AUTHORS   Feng,H., Zhi,Y., Sun,Y., Wei,X., Luo,Y. and Zhou,P.
  TITLE     Draft Genome Sequence of a Novel Streptomyces griseorubens Strain,
            JSD-1, Active in Carbon and Nitrogen Recycling
  JOURNAL   Genome Announc 2 (4), e00650-14 (2014)
   PUBMED   24994798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7563100)
  AUTHORS   Feng,H., Sun,Y., Zhi,Y., Mao,L., Luo,Y., Wei,X. and Zhou,P.
  CONSRTM   Shanghai Jiao Tong University
  TITLE     Draft genome sequence of the novel Streptomyces griseorubens JSD-1
            playing a role in carbon and nitrogen cycle
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7563100)
  AUTHORS   Feng,H., Sun,Y., Zhi,Y., Mao,L., Luo,Y., Wei,X. and Zhou,P.
  CONSRTM   Shanghai Jiao Tong University
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2014) School of Agriculture and Biology, Shanghai
            Jiao Tong University, Shanghai Jiao Tong University, Shanghai,
            China, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2013-12-24
            Genome Coverage                   :: 246x
            Sequencing Technology             :: Illumina Miseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000709915.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 03:19:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,036
            CDSs (total)                      :: 6,948
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 329
            CDSs (without protein)            :: 328
            Pseudo Genes (ambiguous residues) :: 0 of 329
            Pseudo Genes (frameshifted)       :: 72 of 329
            Pseudo Genes (incomplete)         :: 272 of 329
            Pseudo Genes (internal stop)      :: 8 of 329
            Pseudo Genes (multiple problems)  :: 23 of 329
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:40:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 223687
            Orig. end                         :: 235067
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KL503830.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11380
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11380
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11380
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6380](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6380)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(333..2126)
                     /locus_tag="DJ64_RS00860"
                     /old_locus_tag="DJ64_26565"
     CDS             complement(333..2126)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004121.1"
                     /locus_tag="DJ64_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26565"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_051724452.1"
                     /transl_table=11
                     /translation="MSTVTVPTAAGADLPARGALRALLPALAAHRAMTARTCAAALLEQ
                     GSLVALVTLAAHTVGIAVIEGRAPTAGTVTALVALVLVRALMTWREMDLSHDLAYRVLA
                     ALRVHVFDGMARSAPARVAGRRSGDLAATAMADVEALEFFYAHTTAQLLAAGTVFTGGS
                     VLLILVEPWLLVAVLPVAALLAAAPFADAGARTVRGGRTRTAVAALSADTVETVDGLRE
                     LLAFGALAERRRTLAERGRQVGGAQRAEATWEAVAAAVRDLLIVVAVLGVVAAAAQSVT
                     SGRLHGAWVPAAMALALSVLGPVAESARALSQAVALRTAAARVDAAVKAPALAPPPTAP
                     RPLPPGPLGVRLHRVRFDYGGTPVLDGVDLTVRPGRTLALVGASGAGKSTCAHLLARFW
                     DPSAGEVQLLPADGDPVDVREVNDAELRRAVVLVGQDTPLFHGTLAENLRLAAPEADDR
                     ALAEAARLCGVDRIAPLDTLVGERGATLSGGQRARIALARALLAGPRVLVLDETTAHLD
                     NTGDAELATALRQESRTTIFIAHRPATIRRADRIAVLEDGLITEEGTWEDLTSSPDSAL
                     NRILSDTALTGHGSSPREPDQ"
     gene            complement(2123..3862)
                     /locus_tag="DJ64_RS00865"
                     /old_locus_tag="DJ64_26570"
     CDS             complement(2123..3862)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="DJ64_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26570"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_037637605.1"
                     /transl_table=11
                     /translation="MIVHPELRRAARHARRPLLAAALLQGAVTLTHLAQAVLLALALAG
                     LARGDTGQLPWLLAGVLAVVAARAELALWQRRTATRAGARVRVALRDELLAHLGRLGPA
                     YLTTARAGAVRTTLVDGVEGVDAYVSRYLPQLLVTLAVPPLVLAVLVVVEPRALLGLVP
                     ALLLALLGPRAWDRLLAARGKEHWDTYEGLGADYLEALQGMPALRAAGAVGRTRARLEE
                     RSAALHRATVAKLRVSLVDTGITDLAIQGGTAAAALLACWSAVTGSTTAAGTYLVLLLA
                     SECFRPVRDHAREWHAGYLGVSAADGLASLRTSVPAVPDTATAPAHWHTPPELSFHSVR
                     FTYDGAPAPALDGVSFTARAGRTTAIVGPSGAGKSTLLALLLRHHDPQEGRITLDGRPT
                     TEYALDSLRQGIAVVSQETYLFHATIADNLRLARPDATDDELTRAARAAGIHDEIAALP
                     DGYATLLGERGATLSGGQRQRLALARALLSDAPVLVLDEATSSVDERREADIVRELLNA
                     VGGRTVLVVAHRLAAVRSADRIVVLDAGRVDAVGDHTGLVDAGGVYTRLVEAGRAHRGE
                     LAA"
     gene            complement(3859..4992)
                     /locus_tag="DJ64_RS00870"
                     /old_locus_tag="DJ64_26575"
     CDS             complement(3859..4992)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048308.1"
                     /locus_tag="DJ64_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26575"
                     /product="hypothetical protein"
                     /protein_id="WP_033274226.1"
                     /transl_table=11
                     /translation="MEDHREDPQTGLVAALARARSPERPGPDTPAGAPVRAWAGPPLPI
                     PQAGPAHLDLRTLLHLSLAASDTSGRLRPTPSAGALHPVDTELVVGTGCSLPPGRYGYD
                     PLRHRVHHVGPPVDGTPPGVTVALSVTAQRTVSHYGHRAWPLLLLDTGHAAAALLLAAR
                     VLGAGESDVRMDGRTENPLAVIRIPPPYGRSPRRPAGTEDPPTPAELLARRSTPPPLVG
                     LPPREALRAVLATAERAGGRGLLRWCAAVGPPRPGLMHLGPEGTALRRYASGEARPTLA
                     AWAAGQAWLADAGAVLLAHGCPADADATHIRRAHLRAGFAVHLAHVTALRHGLAARPVG
                     SWQQADLGAALGAAPGRDWVVHALALGTHHADEESST"
     gene            complement(5001..6380)
                     /locus_tag="DJ64_RS00875"
                     /old_locus_tag="DJ64_26580"
     CDS             complement(5001..6380)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409979.1"
                     /locus_tag="DJ64_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26580"
                     /product="YcaO-like family protein"
                     /protein_id="WP_037637609.1"
                     /sec_met_domain="YcaO (E-value: 1.2e-47, bitscore: 161.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALPLEALVDPVCGIVRKVKPVEHPAGAPPRYTALTAEVSDARR
                     HGLWPADRVSLGTTFGDPEQARVAAIAEGMERYCGNRVPPPGHPDAPLRATAAELADKG
                     LRLYGPADLPAYAPWQYARAKFPYRPLTADTPALWTRGTERLPDGTAAEVWAPVSLTHL
                     NWRQGGLRELPRTHHLNYAGIATGQGLDDAVERGLLEIVERDALELWWHLDGPARGIDP
                     ASVPGLADDLAGSALDLQIVEMPSEFAPCMAALVHDPRLGLSAAGFACKYDPAEAARKA
                     VLEAVHTWVFTQGLTDPDGWVFQAVEAGLLARGLYLDHRADGRYLDVCGEQFEHVRDLG
                     AHVQVWLDERMAVEARRFTEPALGTVSVAEVEPGSRERLESTLREGGHRVMTFDLTTED
                     VAETALRVARVLVSGLLPNAPAAFGYFGSPRLAETAVARGWRATAPSAPEDFTLAPPPH
                     M"
     gene            complement(6377..7237)
                     /locus_tag="DJ64_RS38710"
     CDS             complement(6377..7237)
                     /GO_function="GO:0008239 - dipeptidyl-peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020119.4"
                     /locus_tag="DJ64_RS38710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase C-terminal
                     non-catalytic domain-containing protein"
                     /protein_id="WP_342669021.1"
                     /transl_table=11
                     /translation="MARAAHAGPPLLAVGGHHDHFTEETVALWRAWGGSSARLLLGPWG
                     HPLTAAPGPDAGPAHRLNLGELYVRWARRALTGDLAPGHHGALALGGAGLWLPADAEGE
                     PRAHRMRLLHGSAFTADPVRPLRSDDLTVPADGPPDRCLLVTPPSPRPLDLVGLVSVRL
                     RATAHTPSADWAARLVVLPPDGAAERLAVGVVRRAEPAGQETAFTVGLGRLARRLRAGT
                     RLRLEIAGHHFPAHARNPHTGDDPMTAAQLLASRREVDPDSVVLNLPVLPSRPAPTDPA
                     EEILR"
     gene            complement(<7548..7952)
                     /locus_tag="DJ64_RS38715"
                     /pseudo=""
     CDS             complement(<7548..7952)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00976.1"
                     /locus_tag="DJ64_RS38715"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTAFSTAVGELATDVLLPAGHGPFPAVLVRTPYDRTRHEAEARAW
                     ARRGFAAVVQDVRGRFASPGEWHPYAHEAADGTAAVRWIREQPWSDGRLVAAGASYAAH
                     CALALALDAPWDARPDAVIAAVPALGLAETA"
     gene            complement(7949..8818)
                     /locus_tag="DJ64_RS00885"
                     /old_locus_tag="DJ64_26590"
     CDS             complement(7949..8818)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048303.1"
                     /locus_tag="DJ64_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26590"
                     /product="hypothetical protein"
                     /protein_id="WP_037637611.1"
                     /transl_table=11
                     /translation="MSRSRLVPGAEVVAVPGRGLAVRTPAGEFFSVRTGDVDEDALLSL
                     LTGGTTAPEDEGTERVIRAFEEAGYLEAGYLAEAPSRPEWPAARQDVRILGDPVLTEPL
                     AVQLAALGARPRTTPAVTDFGSSPVGIEDLLDGHPSAVVWCLDGPVPDGLWDAADRLPE
                     HGVAWLRCHREGWQAYVEPVAAAPGDVTSAHVRSRRLAATPAHRELAAYWSGPRTSGAP
                     VRLAVPAATLLAALLADDLGRWATGASGPAGFPVRRRLRRVDLRTLTVTEHPVLPVPDV
                     APIPKKDG"
     gene            complement(8909..9022)
                     /gene="amiA"
                     /locus_tag="DJ64_RS37655"
     CDS             complement(8909..9022)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004115.1"
                     /locus_tag="DJ64_RS37655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_240449383.1"
                     /transl_table=11
                     /translation="MENEQVFAPIADPGQLAHDSASHSNALVENPFEDTEE"
     misc_feature    9079..9092
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.45"
                     /tool="antismash"
     misc_feature    complement(9079..9094)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            complement(9080..9901)
                     /locus_tag="DJ64_RS00890"
                     /old_locus_tag="DJ64_26600"
     CDS             complement(9080..9901)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004114.1"
                     /locus_tag="DJ64_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_033274230.1"
                     /transl_table=11
                     /translation="MNESVGIHVEGVHFGYPGRPVLRGVDLTVRPGELTALIGLNGCGK
                     STLLRLAAGLLKPDEGRVLLGEDDVTRLSRRATARKVALLHQSAPAVPGMTVRHLVRQG
                     RYAARGPLGMLREGDDPVVRRALRDVGVEDWADRDVDALSGGERQRVRLAMALAQDTRV
                     LLLDEPTTYLDLHHQLDVLQTVVRLREERGLTVVMVLHDLAHAARFAERIVALREGRVA
                     ADGAPKQVVTPGLLAEVLQVAGRVGEDPEGGWPVCYSDHPIAAIEYENQIH"
     gene            complement(9922..10929)
                     /locus_tag="DJ64_RS00895"
                     /old_locus_tag="DJ64_26605"
     CDS             complement(9922..10929)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328328.1"
                     /locus_tag="DJ64_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DJ64_26605"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_037637613.1"
                     /transl_table=11
                     /translation="MTRRFTALGVLAVVCAAVELVAGRGMSPGVVWDVLNGGGDATERH
                     ILFQLRLPRLLVALGAGACLAVAGLVLQSALRNPLAGPEVTGVTPGAVLGAVTATALGL
                     AGWDSPLAVVLAACAGGCAGAALLWLLAGRGRGDPAQTAVHGVLVSAVLGGLTAMVLLV
                     EPGELGSVVQWLVGTTEGRVWEHWHLLWPWALVWGVAAWLLAGPLTLLRCGDDIALAAG
                     LSARRARTLALMCAVALTAGAVAAVGALGFIGLLVPHLAVAVFGADLRRSLPGAALTGA
                     VVVCGADAVAQLSSRLLATALDSGRLTLPVGALTACLGAALLLLVVRRTPSRTF"
ORIGIN
        1 tccgccgcca gtcgccgcag cagggcgctg gaccggttcg ccttgtgcgc gaagtagacc
       61 cgcccggtga gacggtggcg gcggtagacg gcacggaagc gggcggcgtt cgtggccacg
      121 gcctcgggga gcagcacatt gagcggcgac cccagcccgt cggcgagcga gtgcaggaag
      181 ggcccgtccg ccagcagtgc ggcgagcggc ggttccaccc tgggcctcag gtacaagggc
      241 gcgtccacgt gagacccctc ccgttgccgg ccgaccgccg acgcgacggt cgttcgggag
      301 tagtcgtttc cacgtacacc cgtacctaag cgtcactggt ccggttcccg gggcgaactg
      361 ccgtgcccgg tgagggcggt gtcactgagg atgcggttga gcgcgctgtc ggggctgctt
      421 gtgaggtcct cccaggttcc ctcttccgtg atgaggccgt cctccaggac cgcgatgcgg
      481 tcggcacggc ggatggtggc cgggcggtgg gcgatgaaga tcgtcgtgcg gctctcctgc
      541 cgcagcgcgg tggcgagttc ggcgtcgccg gtgttgtcca gatgcgcggt ggtctcgtcg
      601 agcacgagga cgcgcggtcc ggccagcagc gcgcgggcca gggcgatgcg ggcccgctga
      661 ccgccggaga gcgtggctcc ccgttcgccg acgagggtgt ccaggggggc gatccggtcg
      721 acgccgcaca gccgtgccgc ctcggccagc gcccggtcgt cggcctcggg cgcggcgagc
      781 cgcaggttct cggcgagggt gccgtggaag aggggggtgt cctgtcccac caggaccacc
      841 gcccgccgca gttccgcgtc gttcacctcc ctcacgtcca cgggatcgcc gtcggcgggc
      901 agcaactgga cctcgccggc ggacgggtcc cagaagcgtg ccagcaggtg ggcgcaggtg
      961 gacttgccgg cgcccgaggc gccgacgagg gcgagtgtcc ggccggggcg gacggtgagg
     1021 tcgacgccgt ccagcacggg ggtgcccccg tagtcgaacc gcactcggtg caaccggacg
     1081 cccagtggtc ccggaggcag gggacgtggt gcggtgggcg gtggtgccag tgcgggggcc
     1141 ttgacggccg cgtcgacgcg ggcggcggcg gtgcgcaggg ccacggcctg gctcagggcg
     1201 cgggcggact ccgcgaccgg gccgaggacg gacagggcca gcgccatcgc ggccgggacc
     1261 caggcaccgt gcagccgtcc ggaggtcacg gactgtgccg ccgcggcgac cacgccgagg
     1321 accgcgacca cgatgaggag gtcgcggacg gcggcggcga cggcctccca ggtggcctcg
     1381 gcgcgctggg cgccgccgac ctgccgcccc cgttccgcca acgtgcggcg gcgttcggcc
     1441 agagcgccga aggcaagcag ttcgcgcagc ccgtcgacgg tctccaccgt gtcggccgac
     1501 agcgcggcca cagctgtgcg ggtgcggccg ccgcgcaccg tgcgcgcgcc tgcgtcggcg
     1561 aagggcgccg cggcgagcag ggcggcgacc ggcagcacgg ccaccagcag ccacggctcc
     1621 accaggatca gaagtaccga gccgccggtg aagaccgttc ccgccgcgag cagctgggcg
     1681 gtggtgtggg cgtagaagaa ctccagcgcc tccacgtcgg ccatggcggt ggcggcgaga
     1741 tcgccgctgc gccggcccgc gacccgggcc ggcgcgctgc gggccattcc gtcgaagacg
     1801 tggacccgca gtgccgccag tacccggtag gcgagatcgt gggagaggtc catctcccgc
     1861 caggtcatca gggcgcgtac gagaacgagg gcgacgagcg cggtgacggt gccggccgtg
     1921 ggagcgcgcc cttcgatgac ggcgatgccc acggtgtgcg cggccagggt caccagcgcg
     1981 acgagagaac cctgttcgag gagcgcggcg gcacaggtgc gggccgtcat ggcacggtgt
     2041 gctgcgaggg ccgggagcag ggcgcgcagc gcgccccgcg cgggaaggtc agctccggcg
     2101 gcggtgggaa cggtgacggt gctcatgcgg cgagttcccc tcgatgggcg cggccggcct
     2161 cgacgagccg ggtgtagacg ccgccggcgt cgaccaggcc ggtgtggtcg ccgacggcgt
     2221 ccacccgtcc cgcgtcgagg acgacgatcc ggtcggcgga ccggacggcc gcgagccggt
     2281 gggcaaccac caggacggtc cgcccaccga ccgcattcag cagctctcgg acgatgtccg
     2341 cctcgcgtcg ttcgtcgacc gagctggtgg cctcgtcgag aacgaggacc ggggcgtcgg
     2401 acagcagggc ccgcgcgagg gcgagccgct gtcgctgccc gccggagagc gtggcgcccc
     2461 gttcgccgag gagggtggcg tagccgtccg ggagggcggc gatctcgtcg tggattccgg
     2521 cggcgcgcgc cgcccgggtg agctcgtcgt cggtggcatc cggacgggcc aggcgcaggt
     2581 tgtcggcgat ggtggcgtgg aacaggtacg tctcctggga gacgacagcg atgccctgcc
     2641 gcagcgagtc gagcgcgtac tcggtcgtcg gacggccgtc gagggtgatc cgcccttcct
     2701 gcgggtcgtg gtggcgcagg agcagggcca ggagggtcga cttgcccgcg ccggacggcc
     2761 cgacgatcgc ggtggtccgt cccgcgcgag cggtgaagga gaccccgtcc agagcgggtg
     2821 cgggagcacc gtcgtaggtg aaccggacgc tgtgaaagct gagttcgggc ggggtgtgcc
     2881 agtgcgcggg cgccgtcgcg gtgtcgggga ccgccggcac ggacgtgcgc aaggacgcca
     2941 gcccgtcggc ggccgacacc cccaggtacc cggcgtgcca ctcccgggca tggtcgcgga
     3001 ccggacggaa gcactcggag gccagcagca gcaccagata ggtgccggcc gcggtggtgg
     3061 atccggtgac ggccgaccag catgccagga gcgctgcggc ggcggtgccg ccctggatgg
     3121 cgaggtcggt gatgccggtg tcgaccaggg aaacccgcaa cttggcgacg gtcgcccggt
     3181 gcagggccgc ggaccgctcc tccaggcgcg cccgggtgcg gccgaccgcg cccgcggcgc
     3241 gcagggcggg catgccctgg agagcctcca ggtagtcggc gcccagccct tcgtaggtgt
     3301 cccagtgttc cttcccgcgg gcggcgagga gccggtccca ggcgcgcggg cccagcaggg
     3361 ccaggagcag ggcggggacg aggccgagga gggcccgggg ttcgaccacg acgaggacgg
     3421 cgaggaccag gggtggcacc gcgagggtga ccaggagctg gggcagatag cgggagacgt
     3481 aggcgtcgac gccctccacc ccgtcgacca gggtggtgcg gacggccccc gcccgcgctg
     3541 tggtcaggta tgccggcccc agccggccca ggtgggccag gagttcgtcg cgcagtgcca
     3601 ccctgacccg ggccccggcg cgcgtggcag tgcgccgctg ccacagggcg agctcggcgc
     3661 gggcggcgac gacggcgagc acgccggcca gcagccacgg gagttggccg gtgtcaccgc
     3721 gggccagacc ggcgagcgcg agggccagca gcacggcctg tgccaggtga gtgagggtga
     3781 cggctccctg caagagggcg gccgcgagca ggggccgccg tgcgtgccgt gcggcgcgac
     3841 gcagctcagg gtggacgatc atgtggaact ctcctcgtcg gcgtggtggg tgccgagggc
     3901 cagggcgtgc acgacccagt cacggccagg cgcggcgccg agagcggcgc cgagatccgc
     3961 ctgctgccag gagccgacgg gtcgggccgc cagcccgtgg cgcagggctg tgacatgggc
     4021 caggtggacg gcgaagccgg ctcgcagatg ggcgcggcgg atgtgcgtgg cgtcggcgtc
     4081 cgcggggcag ccgtgggcga gcagtacggc gccggcgtcc gcgagccacg cctggcccgc
     4141 cgcccaggcg gcgagcgtcg gacgggcctc gccggacgcg tagcgccgca gggccgtgcc
     4201 ctcgggaccc aggtgcatga ggccgggccg aggcgggccg accgcggcgc accagcgcaa
     4261 caggccacgg cccccggctc gttcggcggt ggccaggact gcccgcagtg cttcgcgggg
     4321 cggaaggccc accaacggtg gcggggtgct gcggcgcgcc agcagttcgg ccggggtggg
     4381 cgggtcctca gtccccgcag ggcgcctcgg gctccgcccg tagggcggtg ggatgcgtat
     4441 gacggccagg gggttctcgg tgcgtccgtc catccgcacg tcggattcgc ccgcgcccag
     4501 gacgcgggcc gccaggagca acgccgcggc ggcgtgcccg gtgtccagca acaggagggg
     4561 ccaggcccgg tggccgtagt gggacaccgt gcgctgtgcg gtgacggaaa gtgcgacggt
     4621 cacgcccgga ggcgtgccgt cgacgggcgg gccgacgtga tggacgcggt ggcgcagcgg
     4681 gtcgtagccg tagcggccgg gcggcaggga gcagccggtg cccacgacca gttcggtgtc
     4741 caccgggtgc agcgcaccgg cggagggcgt gggcctgagg cgtccggagg tgtccgaggc
     4801 cgccagggaa agatgcagca gagtccgcag gtcgaggtgc gcggggccgg cctgcgggat
     4861 cgggagcggc gggcccgccc aggcccggac gggtgctccc gcgggcgtgt cggggccggg
     4921 gcgctccggg gagcgggccc gggcgagggc ggcgacgagg cccgtctgcg ggtcctcgcg
     4981 gtggtcttcc acagcggccc tcacatgtgc ggcggaggtg ccagcgtgaa atcctccggc
     5041 gcgctcggcg cggtcgcgcg ccatccgcgc gcgacggcgg tctcggcgag gcgcgggctg
     5101 ccgaagtagc cgaaggcggc gggcgcgttg ggaagcagtc cggagacgag gacccgggcg
     5161 acgcgcagtg cggtctccgc cacgtcctcg gtggtgaggt cgaaggtcat gacacggtga
     5221 ccgccctcgc gcagcgtgct ctccagccgc tcccggctgc ccggctcgac ctctgcgacg
     5281 gataccgtcc cgagcgcggg ctcggtgaac ctccgggcct cgaccgccat ccgctcgtcc
     5341 agccacacct gcacgtgtgc gcccaggtcg cgcacgtgct cgaactgctc gccgcacacg
     5401 tcgaggtagc ggccgtcggc ccggtggtcc aggtacagcc cgcgggcgag cagcccggcc
     5461 tcgacggcct ggaacaccca gccgtcgggg tcggtcaggc cctgggtgaa gacccaggtg
     5521 tggacggctt ccaggacggc cttgcgggca gcctcggccg gatcgtactt gcaggcgaac
     5581 ccggcggcgg acagtccgag gcgcgggtcg tggacgagcg cggccatgca gggggcgaac
     5641 tccgagggca tctcgacgat ttggaggtcg agcgcggagc cggcgaggtc gtcggcgagg
     5701 ccgggcacgc tcgcagggtc gatgccccgg gccgggccgt ccaggtgcca ccacagttcc
     5761 agggcgtcgc gttcgacgat ctccagcagg ccgcgctcga cagcgtcgtc gaggccctgt
     5821 ccggtggcga tcccggcgta gttgaggtgg tgggtgcgag gcagctcgcg caggccacct
     5881 tggcgccagt tgaggtgggt gagcgagacg ggtgcccaga cctcggcggc ggtcccgtcg
     5941 ggcagtcgtt cggttccccg tgtccacagc gccggggtgt cggcggtgag cgggcggtag
     6001 gggaacttcg cgcgggcgta ctgccagggt gcgtaggcgg gcagatcggc cgggccgtac
     6061 aggcgcaggc ccttgtccgc cagttcggcg gcggtggcgc gcaggggtgc gtccgggtgg
     6121 ccgggcggcg gcacacggtt gccgcagtag cgctccatcc cctcggctat cgcggcgacg
     6181 cgggcctgct cggggtcgcc gaaggtggtg ccgagggaga cccggtcggc cggccacagg
     6241 ccgtgtctgc gggcgtcgga cacctcggcc gtgagcgcgg tgtagcgggg cggggcgccc
     6301 gcgggatgct cgacgggctt gaccttgcgg acgattccgc agacggggtc gacgagcgct
     6361 tccagcggca gagccgtcat cgcaggatct cctcggcggg gtcggtgggg gcgggacggg
     6421 acggaaggac gggcaggttc agcaccacgc tgtcggggtc gacctcacgc cgggaggcga
     6481 gcagttgtgc ggccgtcatc gggtcgtccc cggtgtgggg gttgcgggca tgggccggga
     6541 agtggtgtcc ggcgatctcc aggcgcagcc gggtaccggc ccggagccga cgtgccagcc
     6601 ggccgagtcc gacggtgaac gcggtttcct ggccggccgg ctcggcacgc cggacgacac
     6661 cgaccgcgag ccgctcggcg gccccgtcgg gtgggagcac gacgagcctg gcggcccagt
     6721 cggcggacgg cgtgtgggcg gtggcccgca gccgcacact gacgaggccg acgaggtcga
     6781 gcggacgcgg cgacggcggt gtgaccagca ggcagcggtc gggcgggccg tcggcgggga
     6841 cggtcaggtc gtcggagcga aggggccgga cggggtcggc ggtgaaggcg gagccgtgca
     6901 gcaggcgcat gcggtgggca cgcggttctc cctcggcgtc ggcgggcagc cataggccgg
     6961 cgccgccgag cgccagcgcg ccgtggtggc cgggggcgag gtcgccggtc agggcgcggc
     7021 gggcccagcg cacgtacagc tcgccgaggt tcagccggtg ggcgggtccc gcgtccggcc
     7081 ccggagcagc ggtcagaggg tgcccccagg gcccgagcag cagacgcgcc gaggatccgc
     7141 cccaggcgcg ccacagagcg acggtctcct cggtgaagtg gtcgtggtgg ccgcccaccg
     7201 cgagcagggg cggcccggcg tgcgccgccc gcgccacgag gcgcccgcgg tcgggccggc
     7261 gccacagccc cgcccacgag ggcagggcgc gtcccagccg ctcgggcagg ggcgtgcgcc
     7321 gcccgcgcca cgaggcgccc gcggtcgggc cggcgccaca gccccgccca cgagggcagg
     7381 gcgcgtccca gccgctcggg cagggcggtc aacggcaggt gggcgagcag gccggggtcc
     7441 tcggcgaggg ccttgttcag cgcattttcg tcggagtcgc gccggtcgcc gtgggcggcc
     7501 caccatccgg cgcgggaaag cagccgttcc acgccggacg cctcgcgggc ggtctccgcc
     7561 aggccgaggg cgggcacggc cgcgatgacg gcgtccggcc gggcgtccca gggcgcgtca
     7621 agggcgaggg cgagggcgca gtgggcggcg taggaggcgc cggcggccac cagccgcccg
     7681 tcgctccacg gctgctcccg gatccagcgg acggccgctg ttccgtcggc ggcctcgtgc
     7741 gcgtacgggt gccactcccc cggcgacgcg aaccgccccc gcacgtcctg gacgacggcg
     7801 gcgaacccgc ggcgggccca ggctcgcgcc tcggcctcgt gccgggtccg gtcgtagggg
     7861 gtgcgcacca ggacggccgg gaagggtccg tggccggccg ggagcaggac gtcggtggcg
     7921 agttccccca cagccgtgct gaacgccgtc atccgtcctt cttcggtatc ggcgcgacgt
     7981 cgggcaccgg cagcacgggg tgctcggtga cggtcagcgt gcgcaggtcc acccgtcgca
     8041 gtcggcgccg taccgggaag cccgccgggc cggaggctcc ggtggcccac cggccgagat
     8101 cgtccgcgag cagcgccgcg agcagcgtgg cggcgggcac ggcgagccgg accggtgcgc
     8161 cggaggtacg cggtccgctc cagtacgcgg ccagttcgcg gtgagcgggt gtggcggcga
     8221 gcctgcggga gcggacgtgc gccgaggtga cgtccccggg agcggcggcc accggctcga
     8281 cgtacgcctg ccagccctcg cggtggcagc gcagccacgc gacaccgtgc tccggcagcc
     8341 ggtcggcggc gtcccacaag ccgtccggca cgggtccgtc caggcaccac acgaccgcgg
     8401 agggatgtcc gtcgagcagg tcctcgatgc ccaccggcga gctgccgaag tcggtcacgg
     8461 ccggggtcgt acggggccgc gcgcccaggg ctgccagttg cacggcgagc ggttcggtca
     8521 ggaccgggtc gccgaggatc ctgacatcct gacgagcggc gggccactcc gggcgcgacg
     8581 gagcttccgc cagatagccg gcttccagat agccggcttc ttcgaacgcc cggatcacgc
     8641 gttccgtccc ctcgtcctcc ggggccgtgg tccccccggt gagcagggag agcaaggcgt
     8701 cctcgtcaac gtctcctgtt ctgacactga agaactcccc tgcgggggtg cggacggcaa
     8761 gccctcgccc gggcacggcg acgacctcgg caccggggac gagtcggcta cgggacacgg
     8821 tgttcctcct gtcgacggga gcggggacgg gcgtgggccc gcccggagca tcgggcgggc
     8881 ccacggtcga gggtggccag accctcgctt actcctcggt gtcctcgaag gggttctcga
     8941 cgagcgcgtt ggagtgggag gccgagtcat gagccagctg acccgggtcg gcgatcggcg
     9001 cgaagacctg ctcgttttcc atgaactctc cttcatcagc agggagatac ggcgttcgga
     9061 tgagcgccgt gacctcactc taatgaatct gattttcata ttctatagct gcgatggggt
     9121 gatctgagta acacacaggc cacccccctt ccggatcctc accgacccgg cctgccacct
     9181 gcaggacctc cgccagcaac cccggtgtga cgacctgctt cggcgctccg tcggcggcca
     9241 cacgaccctc ccgcagggcg acgatccgct cggcgaaccg ggctgcgtgg gccaggtcgt
     9301 gcagcaccat caccaccgtg agcccgcgtt cctcccgcag gcgcaccacg gtctgcagta
     9361 cgtcgagctg gtggtgcaga tccaggtacg tggtcggctc gtcgagcagc aggaccctgg
     9421 tgtcctgagc gagcgccatc gcgagccgga cacgttgccg ctcgccgccg gacagcgcgt
     9481 cgacgtcacg gtcggcccag tcctccaccc cgacatcacg cagcgcccgg cgcacgacgg
     9541 ggtcgtcgcc ctcgcgcagc atgcccagcg ggccgcgagc cgcgtaccgt ccctgccgga
     9601 ccaggtgacg gaccgtcatg cccgggacgg ccggagccga ctggtgcagc aaggccacct
     9661 tccgggccgt ggcgcgtctg gaaagccgcg tgacatcgtc ctcgccgagc agcacgcgcc
     9721 cttcgtcggg tttcagcagc ccggcggcca gccgcagcag ggtcgacttg ccgcagccgt
     9781 tcaggccgat cagggcggtc agttcgcccg gccggacggt caggtcgacg ccccgcagca
     9841 cgggtcgtcc ggggtagccg aagtgaaccc cctcgacgtg gatccccacg gactcgttca
     9901 tgctctgtcc tcaattcgac gtcagaacgt acggctcggc gtgcggcgca cgacgagcag
     9961 cagcagcgcg gcacccaggc aggcggtcag cgcgccgacc ggcaacgtga gccgcccgga
    10021 gtccagcgcc gtcgccagca gccgcgagga caactgcgcc accgcgtccg ccccgcacac
    10081 cacgaccgcg ccggtcaggg cggcgccggg aaggctccgg cgcaggtccg caccgaagac
    10141 ggccacggcc agatgcggga cgagcaaccc gatgaagccc agcgcgccga cggcagccac
    10201 ggcgccggcg gtcagggcca ccgcgcacat cagggccagt gtccgggccc ggcgagcgga
    10261 gagaccggcg gcgagggcga tgtcgtcacc gcagcgcagc agggtcaacg gccccgccag
    10321 cagccaggca gcgacccccc agacgagcgc ccacggccac agcaggtgcc agtgctccca
    10381 cacccggccc tccgtggtgc ccaccagcca ctgcacgacg ctgccgagct cacccggttc
    10441 cacgagcagc accatggcgg tgagcccgcc gagcaccgcc gacaccagca ccccgtgcac
    10501 ggcggtctgc gcggggtcac cgcgcccgcg gcccgcgagc agccacagca gcgctgctcc
    10561 ggcgcacccg cccgcgcagg cggcgaggac cacggccagg ggcgaatccc acccggcgag
    10621 ccccagagcg gtcgcggtga cggcgccgag aaccgcccct ggggtcacgc ccgtcacctc
    10681 cggcccggcc agggggttac gcagggcgga ctgcaggacc agtcccgcca cggccagaca
    10741 ggcacccgcg ccgagggcca ccagcagcct cggcagacgc agttggaaca agatgtggcg
    10801 ctccgtcgcg tcaccgccac cgttgaggac gtcccagacc acccccgggg acatgccgcg
    10861 cccggccacc aactccactg cggcgcacac gacggccagc actccgaggg ccgtgaaacg
    10921 ccgggtcacc gtacgtcctc cgttccgatc gtcccgagag gcggcgaggt cggaccaccg
    10981 ggcccgggtt cgccccggtg agcgtgatgc gatgccgcgg cgggaggtac gtcgtccacc
    11041 acacccgaag ccgtcctccg cagctcggac agctgctcgc gcgcaccgac cgaagcggcc
    11101 tgtccgtgcc gggccgtccg gcggcggcca cctgaccgca tcagcgcgac gccggccggt
    11161 acccccagca gggccgtcca cgcgccggcg ggggtctcca cgggtgccag cgccagccgg
    11221 gccgggacat cggcgaccgc cacgacgacc gcgccccagg ccgcggacca ggggagccag
    11281 cgcaccgctc ccgccacggg agcgaaccag cggctcaggt gcggggcgag gaaccccacc
    11341 cacgcgacgg gcccgcacac ggccgtcacc ggggcgatca
//
